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Query: [R] COG2150 Predicted regulator of amino acid metabolism, contains ACT domain, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTEMIHILEEYFRGYPARKKVVKFLWEAGLSVKNGKIYVKDVEVPITGIAEVTGVNRKIVYHTIEYIESKPALKILFENLAPRQSLISIAPLMGWEVLELTISKKAYESTVAMVLNGLAKRRIRVIEIFGTNTYEGKAKVYIVIEGVLPFDMIAELKKTNTIEKIVIRTSEKDKEKMICPKCEVKYCPRKISLTQRSLast
1 -86.000[R] COG2150 Predicted regulator of amino acid metabolism, contains ACT domain  ali  100  1MTEMIHILEEYFRGYPARKKVVKFLWEAGLSVKNGKIYVKDVEVPITGIAEVTGVNRKIVYHTIEYIESKPALKILFENLAPRQSLISIAPLMGWEVLELTISKKAYESTVAMVLNGLAKRRIRVIEIFGTNTYEGKAKVYIVIEGVLPFDMIAELKKTNTIEKIVIRTSEKDKEKMICPKCEVKYCPRKISLTQRS 197
2 -29.000[HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases  ali follow..  14  379..CLQGDLAEYTNSQPLVVAAIKGLLSERVNYVNAAIEAKGIRVIETKDASVRDYSGSLHLKATGTMGEHSATGALLSGEIRITDVDEFPINVPPNNYMLFTLHRDMPGIIGKIGSLLGSFNVNIASMVGRKIVRGDAIMALSLDDPLPDGLLSEITKVAGIRDAYTVK............................ 553
3 -24.400[E] KOG0068 D-3-phosphoglycerate dehydrogenase, D-isomer-specific 2-hydroxy acid dehydrogenase superfamily  ali follow..  10  445..........DLDTRLLRAMITKGIIESYVNLVNADFIAKGLRISEERMVVDSSPVESNFAGAVSDAGDISIEGKVKYGVPHLTCVGSFGVDVSLEGNLILCRQVDQPGMIGQVGNILGEQNVNVNFMVGRTVLRKQAIMAIGVDEEPDNKTLERIGGVSAIEEFVFLK............................ 623
4 -15.800[R] COG4492 ACT domain-containing protein  ali follow..  18  74.................................................................................................FTLILYVTDIVGMLARVLDVISKLELSVLTIHQSIPMEEKATITLSLNAK--EDVIGALRNLDYVSKVELISMS.......................... 151
5 -13.300[R] COG1707 ACT domain-containing protein  ali follow..  19  4.................................................................................................VALSIKTVERPGVLSEITGMIASRNINITYAHLYVERDGHGAIYMELEDI--ESLINELKSSSTVLDVKIHR............................ 76
6 -11.900[E] COG2716 Glycine cleavage system regulatory protein  ali follow..  6  39............DRPGIVNTITRHVSSCGCNIEDSRLAMLGEEFTFIMLLSGSWNAITLIESTLPLKGAE------LDLLIVMKRTTARPRPPMPASVWVQVDVADSPHLIERFTALFDAHHMNIAELVSRAENERAAQLHIQITAHSPASA-----DAANIEQAFKALCTELNAQGSINVVNYSQHDEQDGVK... 212
7 -11.200[E] COG0440 Acetolactate synthase, small (regulatory) subunit  ali follow..  14  1............................................................................................MSPKTHTLSVLVEDKPGVLARVAALFSRRGFNIESLATECKDRSRMTIVVSAEDTPLEQITKQLNKLINVIKIVEQDDEHSVSR------ELALIKVQADAGSRS 102
8 -11.200[S] COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit  ali follow..  12  5..................................................................................................QVNVSARFNPETLERVLRVVRHRGFHVCSMMAAASDAQNINIELTVASPRSDLLFSQLNKLVDVAHVAICQSTTTSQQIRA.................. 87
9 -10.500[T] COG3830 ACT domain-containing protein  ali follow..  12  28...............................................................................................LPAVITVSGKDRPGVTAAFFRVLSANQVQVLDVEQSMFRGFLNLAFVGIAPERVETVTTGLTDTLKVHGQSV.............................. 100
10 -10.500[R] COG4747 ACT domain-containing protein  ali follow..  13  74..................................................................................................VLGIEMEDVPGSMSRIAEVFGAANINLDYAYAFVTRDQKALLIVRVNEI--DRAIKTLEE....................................... 131
11 -10.300[E] KOG2663 Acetolactate synthase, small subunit  ali follow..  12  78..................................................................................................TISVFVGDESGIINRIAGVFARRGYNIESLVGLNEDKALFTIVVLGTDKVLQQVVEQLNKLVNVIKVEDLSKEPHVER------ELMLIKLNADPSTRS 171
12 -9.510[E] COG2061 ACT-domain-containing protein, predicted allosteric regulator of homoserine dehydrogenase  ali follow..  9  7..................................................................................LDFKLDLNCMRDSMRVSMDIELKDVPGQMLLALQPLSEFKANLITVLHHHQKRTPRQLVLETKPESIEVIKAKLEE....................................... 87
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 2 6 8   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.