current user: public
If you have questions about the server, please let us know.

Query: [R] COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350    .  360    .  370    .
# Score Template Links and tools%idFirst MSKMEEILVIGVNTRPVVESAFRLGYRVYSAGYYCTADFKHYTERRCILRERSGESCGRFHENFSQEKLLEAASDFIERADGIIPLTGAPPLPGEKVLGNSRVDHVEDKYRLYRRIRNSYPTPETHLISDPAEAMEIVAAGEKKYIAKPVSGAGGFGVTEFREGDGEFLLQEYIEGVPVSASVLSTGEDAITVLTSRQIIDRGVPGFEGQFVYAGNMTPGPSGEIEDLASDLILDLSLRGSNGVDLIMRDSELYVIEVNPRIQGTFECAEASLGINMVDAHIRACMGELIEKPDPVSYAVKRILYAPARCRVGEIKTMGVHDLPVPGTIIEEGEPLLTVLASHNSMEAAENLASNICSRVKKELHYLRCPPPRPQGVLast
1 -97.100[R] COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase  ali  100  1MSKMEEILVIGVNTRPVVESAFRLGYRVYSAGYYCTADFKHYTERRCILRERSGESCGRFHENFSQEKLLEAASDFIERADGIIPLTGAPPLPGEKVLGNSRVDHVEDKYRLYRRIRNSYPTPETHLISDPAEAMEIVAAGEKKYIAKPVSGAGGFGVTEFREGDGEFLLQEYIEGVPVSASVLSTGEDAITVLTSRQIIDRGVPGFEGQFVYAGNMTPGPSGEIEDLASDLILDLSLRGSNGVDLIMRDSELYVIEVNPRIQGTFECAEASLGINMVDAHIRACMGELIEKPDPVSYAVKRILYAPARCRVGEIKTMGVHDLPVPGTIIEEGEPLLTVLASHNSMEAAENLASNICSRVKKELHYLRCPPPRPQGV 377
2 -55.900[R] COG1821 Predicted ATP-utilizing enzyme (ATP-grasp superfamily)  ali follow..  16  2.....KLFLFETCGERIEDSTAVEGFKSAFDGFKNYYEITGFVRPEFSCLFTLPVDSMDSMEKYLEKSDAFLIIAPEDDFLLYTLTKKAEKYCENLGSSSRAIAVTSDKWELYKKLRGEVQVPQTS-----------LRPLDCKFIIKPRTACAGEGIGFSDEVPDGHIAQEFIEGINLSVSLAV-GEDVKCLSVNEQIINN---FRYAGAVVPARISDEVKREVVEEAVRAVECVGLNGYVGVDIVYSDQ-PYVIEINARLTTPVVAFSRAYGASVADLLAGGEVKHVRRQRKSKSAEKPYVSVGDYTLEIIDL.............................................................. 303
3 -42.300[F] COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)  ali follow..  14  9TPKATKVMMLGSGGKEVVIELQRLGVEVIAVDRYANAPAQQVAHRAYTISMLDGEALKALVEKEKPDYIVPEVEAIATAT-----LVELEQAGFTVIPTAKATQLTMNREGIRRLAELGLPTSNYQFVDNFDDFKRAVEKIGIPCVVKPIMSSSGHGQSILKSVEQRVIVEGFVKFDYEITLLTVRHVHGTSFLAPIG--HIQIDGDYRESWQPQAMSAVALEKAQAIAEKITGALGGRGIFGVEMFVCGDEVIFNEVSPRPHDTGMVTLISQELSEFALHARAILGLPIPDITLISPSASKAIVVEGKSTQVVFGQAEVLAEPHTKGEVDGHRRMGVILARDISVEKALEKARRAYDKLEIAL............. 393
4 -32.900[EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)  ali follow..  17  5.TDIQKIMVIGSGGTQACLSLKEEGYEVVLVNSNPATIMTEIADKVYIEPITLEFVTRILRKEGPDALLPTLGGQTGLNMAMELSKNGILDELGVELLGTSAIDQAEDRDLFKQLMELEQPIPESEIVNTVEEAVAFAATIGYPVIVRPAFTLGGTGGGMCANEKEQCLIERSIAGKEIEYEVMRDSDNALVVCNMENFDPVGIHTGDSIVFAPATMSDYENQMLRDASLSIIRALKIEGGCNVQLALDPNKYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEVINPVTGSTYAMFEPADYVVAKIPRFPFDKFEKGERRLGTQMKTGEVMAIGRNIEESLLKACRSLE................... 401
5 -32.600[F] COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)  ali follow..  14  8KTNNLTIGIIGGGGRMLAMAAARLNHRTIVLEPQADCPAAQVCNDQIVAEYDDEKALAELASRCD-------VVTYEFENVPVAAAEKLSASVPV---PAQALSASQDRLTEKRFLNGGIPTADFRAVDSQDELEAALTAFGGKGVLKTRMGYDGKGQRLFRGGENPLILESFVA-REISIIAARFDGTVTCYDPAENVHLNGILHTS---TVPAALSDAAKAVAVQSAEKLLAALEYVGVIGIEFFVLPDGSLVAEMAPRVHNTGHWTEAACAISQFEQHIRAVSDLAPGSTDRHSDCVMTNLIGDDINDVPAWLSKKDCLVHLYGKEARPGRKMGHVTELLHTGKA............................. 363
6 -31.500[R] COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)  ali follow..  9  15..DKDKITIGSHSALDIADGAKEEGLPTLVVRKTRDGLVKGFIDEVIVLD--KFAQIIEIQEELRKRNVIFVPNR---SFVVYTGIDRVENEFLVPMFGTRRTEERSEEKSYYWLLEKKLPYPEPVSPEEIDD------VGLVIVKLPHAKKRLERGFFTAASYKEKARIERYIIGPVFNFDFFYSDGEIELLGIDWRFETSLDGHVRLPAAQSSTLRESLLEKVFDMAEKYVEATGIIGPFTLQTAVDKDLFYIYDVAPRTGGGTN-IHMAMGHPYGNSLWRMSTGRRIALEIKRAIELDEL.......................................................................... 375
7 -28.300[R] COG3919 Predicted ATP-grasp enzyme  ali follow..  16  1MT-IPGVVIIGGGTLALARSLGVLNVPVYYLTHDSPLPGSRFVRETIRWAGPHDDGAMAFLREMAEKPGLKGCLLVPSGDGEVQLVSQHREELSIILPEWTNLQWLCEKPLLYKRAAEGVSIPRTYALTSAADIDGL--DVMFPVILKPHMGGGNTSVIRADDREENVVVQELIPGGGFSYAALWLNGEPIAEFTARRARQYPVDFGYTST----RVEVVDNRQAIEAARKILKSAGHSGLVEVEFKLDDGALKLLDVNPRPWSWFGLCSAA-GINLGGLLWRVANDMPTGQAVIAR................................................................................ 322
8 -24.500[M] COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes  ali follow..  12  1...MKIAVLYGGSGKGIMEALKANGHEVIGIDFHPDQ--------------------VRDLVDLDVDLVFIGLHGRLGEDGKV---QALLDLLNIPYVGTGVQGSA-DKAKAKLFFEAGIRVAEEVVLHSFTDANAFNFTGTYPVVVKPNQEGSTIGLTVAETEEETILIEEFIAGTEVTVAVLGNKGEERSLPVVEIVPKNKLYDYESKYIVPARISEEHTAYVQQAAVRAHQALGCDVYSRVDFIVPNDGPVILKVNTLPGMTYPDAAKGVGMSMIQTFVNLSLKK......................................................................................... 305
9 -24.500[I] COG0439 Biotin carboxylase  ali follow..  13  3....KKILIAGEIALRVIRTAREMGIQTVVVYSTADEKSLLLADESVCVSYLNIPNILSAALMTGAEAIHPGYGFMAENPD----FAEMCREHGIVFIGPESMRALGSKAGGREIAQSNVPVPGTGVLESVDAALLAAKQIGYPVLLKASAGGGGRGQKVIRTQDPAIIMEKFLEEFRHIEVQVMGDGQGHVIHIGERDCSIQRRNQKLIEEAPSTLPESLRQEILAAGVRLAQFVNYAGAGTLEFIMDRDGYYFMEMNTRIQVEHCVSEMISSLDLVRLQIEIAAGLGLNIQQDHGHAIECRINAEDPDK-----------RPAAGKIDDAHFAIGKLIVWHEDRDKAVSRMKRALEETVIQ.............. 411
10 -22.700[I] COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit  ali follow..  14  2....KKVLIAGEIAVRIIRACRDYGLQSVAVYADPDQDALRLADEAYALTYLDISKLIAIAKRAGADAVHPGYGFLSERAE----FAQAVIDAGLIWIGPDVIEALGDKVMARRIAGVGAPLVAGSPVSSAAEVTAFAEQHGLPVAIKAAHGGGGRGLKVAWKMEEECFLERFLDRRHIEAQVIADKHGNVLVLGTRDCSLQRRNQKLIEEAPAPFLSDEQRQKIHDAAKAICAAAGYSGAGTVEFLLGVDGISFLEVNTRLQVEHPVTEETTGIDLVIEQFRIAEGHKLRVLETPEPRGHSM-FLPTPGLISVFDAPSGPGI-ISGSSIPGDSLMAKLIVTGVDRDQVLRRARRALREFRIE.............. 411
11 -20.700[F] KOG2835 Phosphoribosylamidoimidazole-succinocarboxamide synthase  ali follow..  10  2..DSRTVGILGGGGRMIVEAANRLNIKTVILD--ENSPAKQISNSNDHVSFSNPLDIEKLAEKCDV-----LTIEIEHVDVPTLKNLQVKHPKLKIYPSPETIRLIQDKYIQKEHLKNGIAVTQSVPVEQASSLLNVGRDLGFPFVLKSRTAYDGRGNFVVKNKEMPLYAEKWAP-KELAVMIVRSNGLVFSYPIVETIHKDNICDLC---YAPARVPDSVQLKAKLLAENAIKSFPGCGIFGVEMFYLETGLLINEIAPRPHNSGHYTIDACVTSQFEAHLRSILDLPMPKNFTSNAIMLNVLGDKHTKDKELETCERALATPGSGKESRPNRKVGHINIIASSMAECEQRLNYITGRTD................ 384
12 -20.400[HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)  ali follow..  16  20RRGFMRIAFFTFATGLLAMAALNRGHDVVYLTPGDTLRSDDTLAVHATVIRKGKYKKPEAFHAALQDKALERITMDVEEIDALILFGRLAEQRGVVVLNPEGLALAQNKLYFQSF--PEIVRPTTLISRNVEEIRAFADTHPKGVIVKPLQGSGGKNVFKIGSSKETLIAQAYLPA--------AKEGDVRFFMMNGRPLMRDGQYAALRRVPAKG-AVKVTDEIVELAEMMRPKLVEDGMVGLDIV----GDKILEVNVFSPGGLSNILELTNVDFSDTIIEAVETKVSMQAASGGALSNRLLAT....................................................................... 370
13 -19.400[C] COG1038 Pyruvate carboxylase  ali follow..  17  21VLKISKILVASEIAIRVFRAANELGIKTVAIWAEEDKLSRFKADESYQVSYLSIEEVIRVAKLSGADAIHPGYGLLSESPE----FVEACNKAGITFIGPDTMRQLGNKVAARNLASVDVPVVPATLPDDIAEVERMAEEIGYPVMLKASWGGGGRGMRAIRKKEDEVYLEKLVERRHVESQILGDTHGNVVHLFERDCSIQRRNQKVVERAPAPYLSEAQRQELAAYSLKIAAATNYIGAGTVEYLMDADKFYFIEVNPRIQVEHTVTEVVTGIDIVKAQIHILEGAAIGTAESGVPKQEDI-FIPDYGRITAYRSASGFGIRLDGGTSYTGAVIVKVTAWAPEPDEAISRMDRALREFRIR.............. 450
14 -19.200[F] COG0151 Phosphoribosylamine-glycine ligase  ali follow..  17  2.....NILIIGNGGRALAWKVAQSPLADKVFVAPGNAGTALEHKENVNISATDIPALVKFAQDKQIGLTI-----VGPEAPLVIGVVDAFREAGLKIFGPAAAQLEGSKAFTKDFLRHKIPTAEYQNFTEVEPALTYLREKGTPIVVKADGLAAGKGVIVAMTLQERVVIEEFLDGEEASFIVMVDGKNVEPMASSQDH-DTGLNTGGMGAYSPAEIHSRIMKEVIYPTVNGMAAEGNTGFLYAGLMIMNGQPKVIEFNCRFGDETQPIMLRLKSDLVELCLKACDGKLDEVIQWDLRASLGIVLAAEGYPKDYRKGDEISGLPKSGKLVTNGGRVLCVTALGESVFEAQQKALKLAEQIQ................ 408
15 -19.000[IE] KOG0238 3-Methylcrotonyl-CoA carboxylase, biotin-containing subunit/Propionyl-CoA carboxylase, alpha chain/Acetyl-CoA carboxylase, biotin carboxylase subunit  ali follow..  14  47.PKFDKILIAGEIACRVIKTARAMGIKTVAVHSDVDSNSLKMADEAVCVSYLRADRILQAVEDTGAQAVHPGYGFLSENTK----FAAELEKAGAKFIGPKAILDMGDKIHSKKIAAARVSMIPGYEIADEDMCVKVSRDIGYPVMIKASAGGGGKGMRVAWNDDDRMLVEKFIDNRHIEMQVLCDKHGNALWLNERECSIQRRNQKVIEEAPSSFVPPEMRRKMGEQAVQLAKAVGYDSAGTVEFLVDSQRFYFLEMNTRLQVEHPITECITGIDIVQQMLRVSYGHPLPITQENGWAFESRVYAEDPGRLSRYVEPKHVDGVRCDSGIREGSEICKLVTHGDNREQALNRMQEALDNYVI............... 461
16 -18.800[F] KOG0237 Glycinamide ribonucleotide synthetase (GARS)/Aminoimidazole ribonucleotide synthetase (AIRS)  ali follow..  15  1MEPII-ALLIGNGGRTIAWKLCESPLISKVYVAPGNGGTASNGAENVNIGVCDFEQLVKFALDKDVNLVI-----PGPELPLVEGIEGHFRRVGIPCFGPSAARMEGSKVFSKDFMRNNIPTAVYKSFSNYDHAKSFLDTCTFDVVIKADGLAAGKGVIIPKTKKENVVIEELLEGEELSILTFSDGYTCRSLPPAQDH-DKGPNTGGMGCYAPTKLLETVQSTIIQPTIDGMRHEGYVGILFTGLMLTPSGPRVLEYNVRFGDETQAVLPLLESDLAEIILACVNHRLDAIDVISRKFSCAVVCVAGGYPGPYNKGDIITFDALKGNVVTNGGRVLAVEATGDSVEAAVRLAYEGVKTVH................ 412
FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 5 1 6   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lukasz Jaroszewski, Zhanwen Li, S. Sri Krishna, Constantina Bakolitsa, John Wooley, Ashley M. Deacon, Ian A. Wilson, Adam Godzik, Exploration of Uncharted Regions of the Protein Universe. Plos Biology. 2009 Sep. 7(9):e1000205