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Query: [S] COG3294 Uncharacterized conserved protein, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MQTLTYEVGVKLIEKVLPDSEKVKKVWELLTSDTEVQAYLKMANVFAVQRLRYNDHGPVHSRIVAGSALAIYKILTEKGFKPSVVADGVGDWEDSIIVTLMGAYLHDIGNSVHRTHHPIYSAVLTDRIAEKILSKIYGSTEKMYMLKQEIMHAVFCHDEAYNCLTFEAACAKIADGTDMSSGRARYPYRAGKNDIHALSAMAIERVELVANEARPLAINVYMANETGVFQVDTVLGQKIATSGLAPYVEVRAYVRGKLFAVRTFETTHVIRSLast
1 -106.000[S] COG3294 Uncharacterized conserved protein  ali  100  1MQTLTYEVGVKLIEKVLPDSEKVKKVWELLTSDTEVQAYLKMANVFAVQRLRYNDHGPVHSRIVAGSALAIYKILTEKGFKPSVVADGVGDWEDSIIVTLMGAYLHDIGNSVHRTHHPIYSAVLTDRIAEKILSKIYGSTEKMYMLKQEIMHAVFCHDEAYNCLTFEAACAKIADGTDMSSGRARYPYRAGKNDIHALSAMAIERVELVANEARPLAINVYMANETGVFQVDTVLGQKIATSGLAPYVEVRAYVRGKLFAVRTFETTHVIRS 272
2 -30.200[R] COG1418 Predicted HD superfamily hydrolase  ali follow..  11  299IEELVEKNRLEMDNRIREYGEAAAYEIGAPNLHPDLIKIMGRLQF----RTSFGQNVLRHSVEVGKLAGILAGELG-----------------ENVALARRAGFLHDMGKAIDRESHVEIGMEFA----------------RKYKEHPVVVNTIASHHGDVEPDSVIAVLVAAADALSSARPGARNESENYIKRLRDLEEIATNSFALQAGREIRIMVQPEKISDDQVVILSHKVREKIENN-----LDYPGNIKVTVIR--EMRAVDYAK. 535
3 -26.500[R] COG2316 Predicted hydrolase (HD superfamily)  ali follow..  12  1.............................MISRERAMELLK--------THVKTKNLVKHCLAAEAVMRALAREF-----------------NEDEEKWGLAGLLHDLDYDYTKDKPEEHGLKTL-----EILKDEDVPED--------VLNAILAHCEKKTPETLMEKALYAVDPTTGFIVAAALIRPEKKLDVIDVDFLL-KAFAKGASREQMRTCENFGLSLEKFLEISLEAMKTIASE.............................. 179
4 -20.100[H] COG1713 Predicted HD superfamily hydrolase involved in NAD metabolism  ali follow..  8  2..................................SYQDYINCSREALLEKMALPEKRLTHCLGVERAAMELAQRFG-----------------VDVEKASLAGLLHDYAKKLSDQEHGMVGIYKIQEDLD-----------------SEILRAIEIHTVGAGQMTDLDKVIYVADYIEHNRA----------PGVDVAREIASLSLNKAVAYETARTVEYLAHQGFPIYPQTLETYNAFVHYLKED.......................... 197
5 -19.500[R] COG3481 Predicted HD-superfamily hydrolase  ali follow..  12  109KNEMMDTITQYIFEMKNPNIQRITRFL------KKHEAEFMDYPAATKNHHEFVSGLAYHVVSMLNLAKAIADL----------------YPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGTELSKAAEELQIDSEEVLILQHLILSHHGKAEPMVKEAEILHYIDNLDAKMNMMD....................................................................................... 284
6 -19.000[S] COG4339 Uncharacterized protein conserved in bacteria  ali follow..  9  1..........................MTKMKDQPLIDELLKQELSALYRAEDRHYHNLAHIEAMLALAADHRALLS------------------DPQAVEAAIWFHDAIYDSKAKDNEARSAALAAQKLASRTDP---------ERLDRIGAMILATATHQVPRTRDASLFLDMDLSILGAAPHA--FDAYERAVRR-EYGWVEEPMWRAGRGAVLKDFLARPRIFHTEEFRQRFEPQARLNMARSLEALT..................... 201
7 -18.600[L] COG2254 Predicted HD superfamily hydrolase, possibly a nuclease  ali follow..  11  18..........................................................DHIRKGLEIIEGLYLRRGYGHFLSKILN----DVKLAEELLKKAYIFHDIGKCEKFRFHEVYSALVAREVFKK-----------YGDIGGVVSVAILLHHHNWIREKSILLPLVVADNYAAA--------------------------VNRGGKKSALGKEIFEVLKVRGWKVASSFSSRF................................. 220
8 -15.500[R] COG4341 Predicted HD phosphohydrolase  ali follow..  12  13.................................EFIADIFERRGAESYLGEPVTM--SEHMLQGAWLAEQ----------------------DGAPEALVAAALLHDIGHYTSEFHHDEAGGEVLAPFFPP-----------------VIVECVRLHDFRKNPFHEEAVRVRIWDEGGKVANMKTRAFRDYVPLLQRVVHDFSNHA.................................................................. 194
9 -13.200[F] COG0232 dGTP triphosphohydrolase  ali follow..  14  45.....TTRGRLFPEAGSLTRSEFQRDRDRIVHTTAFRRLKHKTQVFISPDGDHYRTRLTHTIEVAQIARALARALK-----------------LDEDLAEGVALVHDFGH-----GHTGEDAL-SLRIVTKL--ERRYAEYDGINLTWETLEGLVKHNGPLVYASLEAQVAAIADDIAYNTHDIDDGLRAGYLTFEMLEEVPFLSKLMAEVRGKYPVLDKERFANEIMRRQITHMVEDVIGVAQQN.......................... 306
10 -13.100[R] COG1480 Predicted membrane-associated HD superfamily hydrolase  ali follow..  16  474.............................ILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMVANLSEAACEAVGANGL-----------------LARVGAYYHDLGKTKRDNPHDKLSPQLSKNIIISHTTD-GANMLRSYKFPKELVDIAEQHHGTSKPQSKEAAIISVADSVEAA---VRSMHNPNPERIEKLVRGIISD-KLQDGQECDLTFELDTIAKTLCATLKGIFHSRIE................................ 702
11 -12.800[R] COG1896 Predicted hydrolases of HD superfamily  ali follow..  15  22..SASSAVEKPIHQQGSESAMQESHFFAHLAR-------MKLIQRWPLMRSISSENISEHSLQVAFVAHALAVIKNKK-------------GTLNPERIALLAMYHDTSEVLTGDLPTPIKYFNPEIAKEYKKIEAAAERRLLDMLPEELRDDFRPFLISNTADPDESAIVKQADAICA............................................................................................. 180
12 -12.100[O] COG2844 UTP:GlnB (protein PII) uridylyltransferase  ali follow..  14  399...QLRHARRHLQQPLCNIPEARKLFLSILRHPGAVRRGLLPMHRHSV--VGQMQFDLFHAYTVDEHTIRVMLKLESFASEET-LCVDVWPRLPSTELIFIAALFHDIAKGRG-GDHSILGAQDVVHFAELH--------GLNSRETQLVAWLVRQH--------LMSVTAQRRDIQDPEVIKQFAEEVQTENRLRYLVCLTVADIC................................................................. 599
13 -11.100[FP] COG0248 Exopolyphosphatase  ali follow..  13  325........................................................SLNQAKRTAETAQTFMDSLC------HAKNVTVQELALWQQYLGRAAALHEIGLDIAHTGYHKHSAYI---LENADMPGF------SRKEQTILAQLVIGHRGDMKKMSYAVLSLRLAALFCRSR........................................................................................... 444
14 -11.000[R] COG1078 HD superfamily phosphohydrolases  ali follow..  13  2......KFKKAIRDPIHGFIKLTEEEVKLIDGEPLIQR-LRYIKQLGFVYLVYATHTFDHSLGVMHIATLLGQRIM---------QLLGEVDEELLRHLRAAALLHDIG-------HLPFSHSFEILTRELLVDKLSPRLSELGYDPDLIKNLLFNSDGKYKLYNKILSGVFDADRLDIMRDMYFTGAAVGTSFTYVDLERIVENLEIDGDN-----FRFNEKARVNLEGYRYNLYRHVYLHHKTVLFTE...................... 260
15 -10.900[T] COG2206 HD-GYP domain  ali follow..  16  154LNMLFAKMNAHTTLPARPADMLAKRLSELVRANTLGFVSLVLSYKIEGFRF------AKPAVDTAIFSIIVAQHL--------------GFSEKDIFDLVVASLLHDIGM-----------QHVPADILKK-LHFQEQQAVDAHTIYNSVGLSVLQHHESGNKITIGARILAVTDNFAA............................................................................................. 326
16 -10.500[KT] COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain  ali follow..  13  196LLNQNDYLETEVLRRSGELDRMQDAVVFALASLAETRD----------------PETGNHLLRTQHYVKVLAQRLATTDKYRDVLS------PTVIDTYFKAAPLHDIGKV-KLTPDEFTTMRNHALLGKLALEKAEKLSGACTALINVAKEIAMGHHEK-DDIPLSARLMALADVYDA............................................................................................. 373
17 -10.000[R] KOG3197 Predicted hydrolases of HD superfamily  ali follow..  13  57.................DGVSSMESMNHVASSVSSSIDFLTLC---RLKGINGPESIADHMYRMALMALIAGDL-----------------TGVDRERCIKMAIVHDIAEAVPKEEKSRRETAALKEMCEVLGGG---------LRAEEITELWLEYENN---ASLEANIVKDFDKVEM............................................................................................. 197
18 -9.090[T] COG1639 Predicted signal transduction protein  ali follow..  13  251IDDILPSKLLEIQRAIENPDVQLSDIVALISQDVALVDLLKLVNSEAVKRVGLRG--WNQAYRTGYFALGLAKATGD---------------QALIADSYICGLLHNLGEVV-QAERNIPPHVLDTIMSDVGHAEIGAALAQRWNLPEPVINTIRFHHNLPHAPEPLISTVAFANMT............................................................................................... 467
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rodrigues AP, Grant BJ, Godzik A, Friedberg I. The 2006 automated function prediction meeting. BMC Bioinformatics. 2007 May 22;8 Suppl 4:S1-4.