current user: public

If you have questions about the server, please let us know.

Query: [R] COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .
# Score Template Links and tools%idFirst MIIDTHLHLIDKSALNYPWLAGVPALDRDFLYATYAAEAKRVGVAASLHMEVDVDPAEIELETREVARLAGEPGSLLKGAIAACRPEDEGFAAYLERQEENAFVKGFRRVLHVVTDDLSEQPLFRENVKRLSGTRFTFDLCVLPHQIPKAIALADLAPDVQFILDHCGVPDIKGHAEHPWRDHMTEIARHPNVVAKISGVVAYAEEDWALDSIRPYVEHTISVFGWDRVVWGSDWPVCTLGGNLSTWVAATQALIEGCSPQERRKLLSGNAQRIWNLILast
1 -111.000[R] COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold  ali  100  1MIIDTHLHLIDKSALNYPWLAGVPALDRDFLYATYAAEAKRVGVAASLHMEVDVDPAEIELETREVARLAGEPGSLLKGAIAACRPEDEGFAAYLERQEENAFVKGFRRVLHVVTDDLSEQPLFRENVKRLSGTRFTFDLCVLPHQIPKAIALADLAPDVQFILDHCGVPDIKGHAEHPWRDHMTEIARHPNVVAKISGVVAYAEEDWALDSIRPYVEHTISVFGWDRVVWGSDWPVCTLGGNLSTWVAATQALIEGCSPQERRKLLSGNAQRIWNLI 278
2 -21.300[R] COG2159 Predicted metal-dependent hydrolase of the TIM-barrel fold  ali follow..  11  8FIVDSDCHNYWCSATVLFFKDMFVRGEKTNYAIMKEKHLDKYNIDVAILTNAHYANALCRAYNDYMIDYWLPKDSRFWGSIIVAPQDPKLAAEEIRRLGSHPRIVQV--LVSHGAQRPYGDPFYHPIYEACAEMGLPFAMILPQSAMTHMASLIEKWPSLKVVIIECGVAWVPDANYKALRKETPWLKRLPSEYFK-TNIRMSTQPLEQPENVQHLWATLEAMDGENTLLFASDYP-----------WDYDDVTKLHIPPAWREKVLGLNALDVYRR. 356
3 -20.400[R] KOG4245 Predicted metal-dependent hydrolase of the TIM-barrel fold  ali follow..  16  13RKIDVHAHVLPKNIPDF---LFRVVEPNCFDTETRIADMNRANVNVQCLAKPADTEIVARFVNDDLLAECQKFPDRLVPL-GTLPMNDVQRAVEEVKRCVSMGIKGF-EVGSHVAEKSLDHRDFWPLYKICEELGMPSETAQAICSV--MGNILVLFPKLKLCFAHGGGPQIRGRVSHGWNVR-GKCKVAPNKLDGLLWTDSLVHDP-------KALELLINTVGKEHIVLGTDYPFPLGELEVGRVVEE----YKPFSAKDREDLLWKNAVKMLDI. 342
4 -17.000[R] COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold  ali follow..  12  1MYFDSHLHS-------------------EGLGFSELVKLKENGIKEVCSLAFFPVKPKYPQTTEFEPLRCEAAGVKMHPAVGIHPRCIPPDYEFVLGYLEEGEWVAFGEIGLELVTD-EEIEVLKSQLELAKRMDVPCIIHTPRGNKLKATR------KTLEILESLDFPADLAVIDHVNFETLDMVLET-EYWIGLTVQPGKLSAE---------AARIVAEHGPERFMLNSDAG---RDVEITTVAEAAVKIEEAVGREEMEKVARENARKFLRV. 248
5 -13.800[L] COG0084 Mg-dependent DNase  ali follow..  14  3.IFDTHAHIGLIHPDPVE-------------RLRVVQEARRASVTRIMSICNS------LHDFAAVYETLQFSPSVYHAV---VMAPGKDWIDTIQKSLQLPQVVALGETCKKYGDKRSQIGLFITQLDIASKAKKPVIIHNRGAGQDILDILSERIPDQGGVF-HC-----------SEDAEYARMALDLPVYFSFAGNLTYRNAR---------LHETVLALPLDRILVESESPFMS-RPAHTVETVEFMAELLDMDMLELADQLWKNSCACFHL. 255
6 -12.800[L] KOG3020 TatD-related DNase  ali follow..  11  141.YIDSHCHTDYMYTSLARRKTNSNEGLLDW--IEKYPRAFPKCFFGLIANFIKPDKGNSSYDVEWIVKELASPLY-LGTTWGCHPHFAQHWGEYILSDAEEWKVLAVGEC-RCESELEVQKDVFEKHVALAFKFKLPLVIHCRNGSKGRAEEECLQILKKKMDVNHKFLKIHRHCFTENWEVAQMWLKQCPDVHFGFTPAVFTMGAP---------QIQAIRNIPLDRILLETDGPYFK-LPGMAIATASKIAEIKNLPIEEVLRATFNNTRRVYQL. 434
7 -11.900[F] COG0418 Dihydroorotase  ali follow..  11  9.PDDWHLHL------------------RDGAALKAVLPHTVRQFARAIVMPNLKPPVRSVADAAAYRERILAPAGGQFEPLMTLYLTDNTNPEEIIAAKASQFVKAVKGATTNSDFGVTDIHRCDAVLAAMEQVDLPLLLHGEVTDSNYLIPLREKFPRLRVVLEHITT-----------SDAVQFVLSANNIAATITPQHLLFSRNALFKGCLPILKREEHR-GNPKFFLGTD-PCYSALHAMELYAEAFESVNS----DKLEAFASFYGPDFYQL. 301
8 -11.300[E] COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog  ali follow..  14  11VIIDAVAPL--EKKRYVESYKA-GGVTCVAPTVNAGEGSPAAALKEIGSWLHFIRSRKDLRLVQKASDIDAAKRDGHVGILFHFQ-GTGPFETDLNLVEAFQAL-GVRMVQ-EEEIDGGLSRFGKALVRRLNENRVIVDCTHTGYKTTMDALSLTTRP---AVFSHSNSAAVFPSKRNIQDDQAKAAAGTGGLV-QFVVPTEGDAARPSLDDLIAHIDHFVALIGIDHVGLGLDYWWGTLPETPEMFLGMTEGLIRGYKEDDVRKILGLNWLRVFRDV 335
9 -11.000[O] KOG4127 Renal dipeptidase  ali follow..  14  31PVIDGHNDLWQLLDMFNNRLQDERANLTTLAGTHTIPKLRAGFVGGSVYTPCDTQNKDAVRRTDVVHRMCRMYPETFLYVTSSAGIRQAFREGKVASLIGVEG-LGMRYLTDSEPQSQGLSPFGQRVVKELNRLGVLIDLAVSVATMKATLQLSRA----PVIFSHSSAYSVCASRRNVPDDVLRLVKQTDSLVVNFYNNYISCTNKANLSQVADHLDHIKEVAGARAVGFGGDFDVPEGLEDVSKYPDLIAELLRNWTEAEVKGALADNLLRVFEAV 353
10 -10.800[F] KOG2902 Dihydroorotase  ali follow..  11  8.LADMHVHLRQDN-----------------MLKAVVPTVAEGGVSVAYVMPNLIPPITTVDACLQYKKEIEQLDSKTT-YLMSLYLSPETTPEVIYEAAKKG-IRGVKGATTNSESGVESYEPFYPTFAAMQETGMILNI-AEPKFLPTLLDLHQRFPKLKIVLEHCTT-----------ADAVEAVKACGSVAGTIT-LTQKDWQDDPYCFCKPVAKTERDR-KNPKFFFGSD-PVFTQPFAASYLAEVFDK---EGRLDALKDFACIFGRKFYCI. 295
11 -10.600[R] COG1831 Predicted metal-dependent hydrolase (urease superfamily)  ali follow..  2IILDNHFHVDPINGLF----------------LEAVKQFHRAGGTHLVVVYKSAHDYGFGGMVELVEIINKETPVKAYAVVGVHPAEFDYLAEHAQRLCLDGKAIGRPHYPVPEEIWEASIEIMKYAMALAKEADCAVQLHTESFDEEKFRELGRYVREVGIVVKHFSPPLVKVAEEVGIFPSIIASRKNIEEAIKQG----------------------------TRFLMETDYIDDKRRPGAVLGPKTVPRRTKELTEDDVYRIHVENPEKVYGI. 277

FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 6 0 7   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster

Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Pio F, Pawlowski K, Godzik A. Saturated BLAST: an automated multiple intermediate sequence search used to detect distant homology. Bioinformatics. 2000 Dec;16(12):1105-10.