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Query: [R] COG3700 Acid phosphatase (class B), from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKKITLALSAVCLLFTLNHSANALVSSPSTLNPGTNVAKLAEQAPVHWVSVAQIENSLTGRPPMAVGFDIDDTVLFSSPGFWRGKKTYSPDSDDYLKNPAFWEKMNNGWDEFSIPKEVARQLIDMHVRRGDSIYFVTGRSQTKTETVSKTLADNFHIPAANMNPVIFAGDKPEQNTKVQWLQEKNMRIFYGDSDNDITAARDCGIRGIRILRAANSTYKPLPQAGAFGEEVIVNSEYLast
1 -105.000[R] COG3700 Acid phosphatase (class B)  ali  100  1MKKITLALSAVCLLFTLNHSANALVSSPSTLNPGTNVAKLAEQAPVHWVSVAQIENSLTGRPPMAVGFDIDDTVLFSSPGFWRGKKTYSPDSDDYLKNPAFWEKMNNGWDEFSIPKEVARQLIDMHVRRGDSIYFVTGRSQTKTETVSKTLADNFHIPAANMNPVIFAGDKPEQNTKVQWLQEKNMRIFYGDSDNDITAARDCGIRGIRILRAANSTYKPLPQAGAFGEEVIVNSEY 237
2 -61.200[R] COG2503 Predicted secreted acid phosphatase  ali follow..  16  1..........MSVLNAKECVSPITRSVKYHQQSAEIRALQLQSYKMAKMALDNNLKL-VKDKKPAVILDLDETVLNTFDYAGYLIKNCIKY------TPETWDKFEKE--GSLTLIPGALDFLEYANSKGVKIFYISNRTQKNKAFTLKTLKSFKLPQVSEESVLLKEKGKPKAVRRELVAKDYAIVLQVGDTLHDFDAIFAK-----DAKNSQEQRAKVLQNAQKFGWIILPNSLY 215
3 -32.700[S] COG5663 Uncharacterized conserved protein  ali follow..  12  2...............................................................LRLGIDIDGTITAQDTFVPYLNRSFKLLNITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKE-EHKLIYITARRTHLTDITYEWFDRQNIH--------YDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAEAGIPVILFNSPYNQLPIDSNIIRVNNWLEAVQ... 179
4 -26.600[S] COG4502 Uncharacterized protein conserved in bacteria  ali follow..  8  2..............................................................KKVIAIDMDQVLADLLSDWVAYINTYDDPFLKEKDNNNVYRHLDYDLFRNLNVIEGSQRVTKELMKKYEVYVVTTATNHPDSLKAKLEWLTEYFPFIPHSNVV-----------LCGNKNIIKADIMIDDGIHNLESFEGMK---ILFDAPHNRNENRFIRVMNWEEIE...... 168
5 -21.600[R] COG4996 Predicted phosphatase  ali follow..  9  1...............................................................MLIALDLDGTVWDHH----------DISSLYPPFKRVSPLKIQDNRGAEVTLRKHVRDFLQWARNSGHIITTLSWNDFQVAYQALRAFEIDAYFHYLVIEPHPRKDKMLYYLRRIKAERGVEIIVYIDDRDIHIREIWENIGPVRFIQFGIDVKCFLE................ 153
6 -20.200[R] COG0546 Predicted phosphatases  ali follow..  15  10................................................................AVAFDLDGTLCDSVPDLAAAAEAMADSELWEKGFVSYMKYYRDHLSVFTRPYPETEAGLALLKSLGIPLAVITNKNEILAAELLKQL-------GLADYFSLILGGDSLPEKKRHAAEVLGIDVMVGDSRNDIIAAKAAGCLSVGVTFGYGDMTLLSQDDATRPDWIIGSLP. 221
7 -16.700[R] KOG3109 Haloacid dehalogenase-like hydrolase  ali follow..  10  4.......................................................VNSSPPRYECLLFDLDDTLYPLSSGLSDACSNN-DEDGVVELNQILYKKYGTSMAGPYENLKPDPVLRSLLLGLPLRKLVFSNGDEVHVMKALTRL-------EDCFERIISFETLNPDINEEKAFDIAQLNLFFDDSTRNIQTGKAVGLHTVLV........................... 212
8 -16.400[R] COG2179 Predicted hydrolase of the HAD superfamily  ali follow..  17  21.......................................................PSLQAQGIKAVLVDLDNTLIA---------------------------------WNNPDGTPEMKQWLHDLRDAGIGIIVVSNNTKKRVQRAVEKF------------DYVYWALKPFTFGIDRAMKEFHYVVMVGDQLTDIRAAHRAGIRSILVKPLVQHDSIKTQINRTRERRVM..... 159
9 -16.300[E] COG0560 Phosphoserine phosphatase  ali follow..  14  44...............................LPSELRVQLDAICANLKLDYAWIPDEWTFGDFRVLAMDMDSTLITIECIDEIADFCGLKPQVAAITEASM-SVLERVYAERLQLSPGAEHMLKAVQALGIRTLLVSG------DFFTSRLQERLGLDRTRANTLEIVDGK-NADVKAQTLKAF--AIAMGDGSNDLKMMGAAG................................. 251
10 -16.200[E] COG0241 Histidinol phosphatase and related phosphatases  ali follow..  16  2...........................................................SKQQKILFIDRDGTLIVEPPVDFQVDR------------------------DKLKLEPYVIPSLLKLQEAGYRLVMVTNQPQADFDAPHNMMMDIFESQGVKFNDVLICPHFERDNRKKEYLQGGKVDFVIGDRMTDLQLAENMAIRGIQY........................... 150
11 -15.600[R] COG1011 Predicted hydrolase (HAD superfamily)  ali follow..  13  3..........................................................RKEAKMLYIFDLGNVIVDSDEAFAEALCHEMALPLSYEQFSHGWQAVFVA------LRPEVIAIMHKLREQGHRVVVLSNTNRLHTTFWPEEYPEIRDAADHIYLSQDLGMRKPEARIYQHVLQAEGFSVFFDDNADNIEGANQLGITSILVKDKTT...................... 196
12 -15.400[R] COG1778 Low specificity phosphatase (HAD superfamily)  ali follow..  12  2.................................SKAGASLATCYGPVSPHVMTKAENIR-----LLILDVDGVLSDGLIYMGNNGEELKAFNVRDGYG------------------------IRCALTSNIEVAIITGRKAKLVEDRCATLG-----------VHLYQGQSNKLIAFSDLLEKLAIVAYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTHIAG......... 161
13 -15.100[R] KOG4549 Magnesium-dependent phosphatase  ali follow..  10  2........................................................VKNIEFPKCVVFDLDYTL---------------------------WGVLIDKYGTEICFYSDITGILQELRNQKVTLCVASRTCAPKYAKQALNLMKVPIDGSLKPAIEFFTYVKAWPGSKKEIHNESGIMVFFDDESRN-REVERLGVTFCLVPDGLN...................... 159
14 -14.700[C] COG4229 Predicted enolase-phosphatase  ali follow..  13  2.............................................VIGQKVLLARIPKMGDNYSTYLLDIEGTVCPISAHILELVAKDVKDPILKQLQGYVWAHGYESGQIKAPVYADAIDFIKRKK----RVFIYSSGSVKAQKLLFGYVQDPNAPAHDSIDGYFDINTSGKKTETANILRDIGAVLFLSDNPLELDAAAGVGIATGLASRPGNA..................... 224
15 -14.500[R] KOG3085 Predicted hydrolase (HAD superfamily)  ali follow..  10  8................................................................AVFFDLDNTLIDTAGAWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRK-EVRLLLLTN---GDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSYYCCNLLGVQVMVGDTLTDIQGGLNAGLKAT............................. 206
16 -14.500[R] KOG3120 Predicted haloacid dehalogenase-like hydrolase  ali follow..  13  2.............................................................AKIVILFDFDRTLIDGDSDNWVVTEMGLTEIFHQLRFTLPWNRLIKSCLKKMPIDSHIIEAIKSAKSSGCDLKIVSDANQFFIEKILEHHDLVDCFSEIYTNPTSLDDNGDHLRASSSNDQIPRRFIYLGDGGGDFCPTLKLRECDFVMPR......................... 199
17 -14.300[E] KOG2630 Enolase-phosphatase E-1  ali follow..  15  10................................................................ALLLDIEGTITSISFEKRCLKFNIFQLTPMKALQGLIWEEAYQRGDVKGHVYPDVLPVLKIVENRKIPIYIYSSGSVHAQKLLFANSIEGDMTKILYGYFDTNIGLKGESNSYTKISERIKIILFLTDVEAEAAAAKKAGLQTKLVVRPGNA..................... 244
18 -13.500[I] KOG3189 Phosphomannomutase  ali follow..  19  1..................................................MAVIPIEERKFPKTLVLFDVDGTLTPA----------------------------------RLSVSPEMLETLQNLRK-VVAIGFVGGSDLSKQQEQLSVN...................................................................................... 66
19 -13.400[E] COG4359 Uncharacterized conserved protein, possibly involved in methylthioadenosine recycling  ali follow..  8  2.............................................................VKAVIFTDFDGTVTLEDSNDYLTDTLGFGKEKRLKVFEGV-PECIKILEKKIRLDPGFKDTFEWAQENDVPVIVVSSGMKPIIKVL---LTRLVGQESIHKIDIVSNEVEIDAHDQWKI-EQRPVYFYCGDGVSDLSAAKECDL................................ 192
20 -13.300[S] COG4850 Uncharacterized conserved protein  ali follow..  10  82VPNLPVTVTVGGKTVTSSTNDNGYVDLLVEDHNLDPGWHTIQIQAEGSTPAEARVLIVENTARIGLISDIDDTIMVTW---------------LPRALLAAWNSWVLHTNTR-KPVPGMNRFYEELLKDDAPVFYLSTGAWNTFETLQEFINKHALPD-TDWGPTPTGLFRSGQEHKKVQLRNL---ILVGDDYGEAVEEHPNRIAGVAIRELSPGEHVLSHGTTA........... 310
21 -13.300[E] KOG1615 Phosphoserine phosphatase  ali follow..  13  13...................ATLIMIRVALPTTASAIPRSISTSPGETISKNHEEEVKRVWRKADAVCFDVDSTVIDELAAYLGVGEAVANVTRTAMNGNARFRDALAARLQVMKPNVGIRELVSRLHARGTHVYLVSGGFRRLILPVAELLTSELTSDSGSKELKSSITNLFGPTGKPAVIALLK-VVMVGDGATDVEASPPADA................................ 249
22 -12.900[R] KOG2914 Predicted haloacid-halidohydrolase and related hydrolases  ali follow..  10  1.....................................................................MDGLLLDTERLYSVVFQEICNRPMSKEELVEESQTKLKEVFPTAALMPGAEKLIIHLRKHGIPFALATSSGSASFDMKTSRHKEF----FSLFSHIVLGDDPEVQHGKLACAKRFSPPLVFEDAPNGVEAALAAGMQVVMV........................... 180
23 -12.700[K] COG5190 TFIIF-interacting CTD phosphatases, including NLI-interacting factor  ali follow..  11  123.................GYSDMARANISMTHNTGDLTVSLEEASRLESENVKRLRQE----KRLSLIVDLDQTIIHATVDPTVGEWMSDPGNVNYDVLRDVRSFNLQEGPSGIKFRPGLAQFLQKISEL-YELHIYTMGTKAYAKEVAKIIDPTGKLFQDRVLSRDDSGSLAQKSLRRLFPCDTSMVVVIDDRGD.......................................... 301
24 -12.200[R] COG0637 Predicted phosphatase/phosphohexomutase  ali follow..  16  6................................................................AVFFDCDGTLVDSEVICSRASKEHGVALAKAELEPVYRAEVARLFDTELEAIAGANTLLESI---KTPMCVVSNGPVSKMQHSLGKLGMLHHFPDLLFSGYDIQRWKPDPALMLHAANAMKVNILVDDSSAGAQSGIAAGMEVF............................. 183
25 -12.000[R] COG3769 Predicted hydrolase (HAD superfamily)  ali follow..  19  5............................................................QQPLLVFSDLDGTLLDSHSYDW----------------------------------QPAAPWLSRLREANVPVILCSSKTSAEMLYLQKML...................................................................................... 61
26 -11.500[R] KOG1618 Predicted phosphatase  ali follow..  11  9.......................................................SFSQSPPTFGFLLDIDGVLVRGHR-----------------------------------VIPAALKAFRRLVNSQGQVVFVTNAGNILQHSKAQELSALLGCEVDADQVILSHSPMKLFSEY----HEKRMLVSGQGPVMENAQ...................................... 117
27 -11.300[R] COG5083 Uncharacterized protein involved in plasmid maintenance  ali follow..  13  354.................TNDQLKCLNLTYGENDLKFSVDHGKAIVTSKLFVWRWDVPI-------VISDIDGTITKSDA-------------------------HVLAMIGKDWTHLGVAKLFSEISRNGYNILYLTARSAGQADSTRSYLRSIEQNGSK----VILSPDRTMAALRREVILKFKIACLFGNRITDALSYRTVGIPSSRIFTINTEGEVHMELLELAGY----RSSY 571
28 -11.300[NI] KOG2116 Protein involved in plasmid maintenance/nuclear protein involved in lipid metabolism  ali follow..  14  380.................................................................VISDIDGTITKS-----------DALGHMFTLIGKDWTH------------AGVAKLYTDITNNGYKIMYLTSRSVGQADSTRHYLRNIEQNGYS----VILSPDRTMAALHREVILRFKMACLFGNRITDAISYNHVRVPPTRIFTINSAGEVHIELLQRSGH----RSSY 548
29 -10.900[K] KOG0323 TFIIF-interacting CTD phosphatases, including NLI-interacting factor  ali follow..  6  137.RCLSIVFDLDETLIVANTMKSFEDRIEALKSWISREMDPVRINGMS----AELKRYMDDRMLLKQYIDNDYAFDNGVLLKAQPEEVRPTSDGQEKVCRPVIRLPEKNTVLTVKLRPAWEELRSYLTAKTFEVYVCTMAERDYALEMWRLLDPEAHL----SLKELRDRIVCVKPDAKKSLLSVKMAMVIDDRMKVWEDKDQPRVHVVS............................ 360
30 -10.600[R] KOG3040 Predicted sugar phosphatase (HAD superfamily)  ali follow..  12  5................................................................GALIDLSGTLHVEDE-----------------------------------PTPNAVEALKRLRDSGVLVKFVTNTTKDSKATLHERLCRIGF--QLDASEIYSSLSAAVSYVENERLNPYYIL.................................................. 90
31 -10.500[R] COG5610 Predicted hydrolase (HAD superfamily)  ali follow..  11  4.................................................FLDGAKSEVLKYD--VISFDIFDTLLLRP--ILAEMQSRKLSKRQDITLDEIYHQIPKEFHEVLVPNLEMLELYRFAKENNKRVIIVSD----PLEVLEDILISKGF---DGYTNFYLSNHIMLTKHSKHVLKQENITLHIGDNSADDAMPKSLGIATLFRKSVLKQLEE.................. 209
32 -9.720[Q] COG3882 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis  ali follow..  11  236.........................................EVWHCLSPEIVSIVAAQKGLTKKVLALDLDNTL---------------------------WGGVIGDDGVTGIQLSNEQQLIVKLYKQGV-LLTIASKNDW--RNVKDVFTKNEHMIITEEMLTQISCHWNPKTDSRKMAKQLNLFVFADDHPFERDLMQRELPEVTVIPFEQDPSQYAA................ 399
33 -9.660[G] COG0647 Predicted sugar phosphatases of the HAD superfamily  ali follow..  14  5................................................................NVICDIDGVLMHDNV-----------------------------------AVPGAAEFLHGIMDKGLPLVLLTNYPSQTGQDLANRFATAG.................................................................................. 60
34 -9.650[R] COG0561 Predicted hydrolases of the HAD superfamily  ali follow..  15  6.................................................................IVTDMDGTFLND---------------------------------VKTYNQPRFMAQYQELKKRGIEFVVASGNQYYQLISFFPEL...................................................................................... 58
35 -9.540[P] KOG2882 p-Nitrophenyl phosphatase  ali follow..  14  13...............................AINMYKQSCTNLLELSSAKVTEWLAGFD-----SVITDCDGVLWIYGQ-----------------------------------ALEGSVDVMNQLKGMGKSIYFCTNNSTKTRSELLKKGVELGF--HIKENGIISTAHATAAYLKRRNFSKR--VFVIGSE............................................ 130
36 -9.150[R] COG4087 Soluble P-type ATPase  ali follow..  13  141....................................................................................................................KEVKETIKQLKDLGVKVFIASGDRKGFIKRLAEIT--------DERYIMAEAHQELKRDLIRNLKKEGYFTIMVGDGANDVPAMIESDL................................ 223
37 -9.040[R] KOG2961 Predicted hydrolase (HAD superfamily)  ali follow..  15  171.......................................................EVLKRKGFKGVVFDKDNTLTA----------------------------------YSLAIWPPLRPSIERCKAVFHDIAVFSNSAGLTEYDHDD--SKAKALEAEIGIRVLRHRVKKPAGTAEEVEKHFGCLIMVGDRPTDIVYGNRNGFLTVLT........................... 296
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Igarashi Y, Eroshkin A, Gramatikova S, Gramatikoff K, Zhang Y, Smith JW,Osterman AL, Godzik A. CutDB: a proteolytic event database. Nucleic Acids Res. 2007 Jan;35(Database issue):D546-9. Epub 2006 Nov 16.