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Query: [L] COG3857 ATP-dependent nuclease, subunit B, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTLQIIAGKAGTGKTTHLMDEVGEKIKKTSKTYIFIVPDQMTFQMETSFLNKQNLAGMLGTQIFSFSRLAWKILQETGGLSKTFLSQTGIEMVIRKAALDQKDKLKIFSRATSKKGFYSELAKLFKEMKQEEISVDELEKSAANLSTSVSSKVHDISLIYQKYEELLAGKFLENEDYLRLLADKIIESDYLNQTEIIIDGFTSFSKQELTVIEKLMQKCDKVTVSLTLNVPEIHKGLEDFSMFKASTEAYFALLEMAKLNKIQVEPEKILLENKRANSDSLAFLANAWGDNKYSSYEGGANDLTIHQANNRRAEMEGVAREIRQLALNGYRYRDIAILTRNIGDYDILCETVMESFDIPIFIDKKRAMAKHPFIEFIRSSIDAILFNWKYEPIFQAVKTEFFFDVAENATIMRRKADILENYVLENGIQNKWKWEKEGDWIYRKIRGLSTNVLPQTDEELATQSVINEMRNLIVEPLSTLENNITKAKTGIEFAMALYHYLEQVKAVEHLESWRQVAEENGYLELAREHEQAWSSISELLDEFVEVLGEEELDVNSFSEIITTGLDALEFSLLPPSLDQVVLADMENAKLLNMKVIFAIGMNDGVMPLRQKDKGILSDQDRDSLRVENSNLKPSAKNNIGEEDLLAYKIMSLPSDKLFLSYPAADEEGKVLSESNYLRKIKGQFKNLNESVYLTDPSLLNDKEQSSYIRSKQATLGLLTSQLQMYKRGYPLSNVWWDAYNSYFEDSKESEAAKQVLSSLYYENKTKPLQETTAKNLFGENIHASVSRMEKFFSCEFQHFAQYGLKLEERAHYKLQAVDMGEIFHGAMEWISAELKRTNRDWGNLTEEECRQMAKLAMTFLAPKIQHEILLSSKRMEYIQYKLLQIITRATTVLNEQAKSSAFRPIGLEVDFGLKGDIPPLKIPLQSDSELLLQGRIDRIDAAEQDDRTFLRIIDYKSSSHDLALTEVYYGLALQMLTYLDIVVTNAQKMIGKTAEPAGVLYFHMHNQYVQAEKELSDEAIARELQKSSKMKGLILSDPVAVSLMDTNLEKGKSSNIIPAEIKQNGELSARSRTATKAEFDKMRRFVRQKYQEAGNKILDGAVSINPYKLKEKTPCQFCGFRSFCGFDPSLASNQYRHLTNEKTETILTKMDIEGGTQLast
1 -291.000[L] COG3857 ATP-dependent nuclease, subunit B  ali  100  1MTLQIIAGKAGTGKTTHLMDEVGEKIKKTSKTYIFIVPDQMTFQMETSFLNKQNLAGMLGTQIFSFSRLAWKILQETGGLSKTFLSQTGIEMVIRKAALDQKDKLKIFSRATSKKGFYSELAKLFKEMKQEEISVDELEKSAANLSTSVSSKVHDISLIYQKYEELLAGKFLENEDYLRLLADKIIESDYLNQTEIIIDGFTSFSKQELTVIEKLMQKCDKVTVSLTLNVPEIHKGLEDFSMFKASTEAYFALLEMAKLNKIQVEPEKILLENKRANSDSLAFLANAWGDNKYSSYEGGANDLTIHQANNRRAEMEGVAREIRQLALNGYRYRDIAILTRNIGDYDILCETVMESFDIPIFIDKKRAMAKHPFIEFIRSSIDAILFNWKYEPIFQAVKTEFFFDVAENATIMRRKADILENYVLENGIQNKWKWEKEGDWIYRKIRGLSTNVLPQTDEELATQSVINEMRNLIVEPLSTLENNITKAKTGIEFAMALYHYLEQVKAVEHLESWRQVAEENGYLELAREHEQAWSSISELLDEFVEVLGEEELDVNSFSEIITTGLDALEFSLLPPSLDQVVLADMENAKLLNMKVIFAIGMNDGVMPLRQKDKGILSDQDRDSLRVENSNLKPSAKNNIGEEDLLAYKIMSLPSDKLFLSYPAADEEGKVLSESNYLRKIKGQFKNLNESVYLTDPSLLNDKEQSSYIRSKQATLGLLTSQLQMYKRGYPLSNVWWDAYNSYFEDSKESEAAKQVLSSLYYENKTKPLQETTAKNLFGENIHASVSRMEKFFSCEFQHFAQYGLKLEERAHYKLQAVDMGEIFHGAMEWISAELKRTNRDWGNLTEEECRQMAKLAMTFLAPKIQHEILLSSKRMEYIQYKLLQIITRATTVLNEQAKSSAFRPIGLEVDFGLKGDIPPLKIPLQSDSELLLQGRIDRIDAAEQDDRTFLRIIDYKSSSHDLALTEVYYGLALQMLTYLDIVVTNAQKMIGKTAEPAGVLYFHMHNQYVQAEKELSDEAIARELQKSSKMKGLILSDPVAVSLMDTNLEKGKSSNIIPAEIKQNGELSARSRTATKAEFDKMRRFVRQKYQEAGNKILDGAVSINPYKLKEKTPCQFCGFRSFCGFDPSLASNQYRHLTNEKTETILTKMDIEGGTQ 1157
2 -57.000[L] COG3893 Inactivated superfamily I helicase  ali follow..  12  1MTLRVLTIAAGTPFLKTLAETLCDGRLTAGASVTIYVPTRRSARVRSEFVDLLGGRSAILPLIRPLGETDDDSGFFDIENPAPPISGTGRQIELARLILAWRNSLVAPASPADAIWLARALGEVIDAMDTEEKDWEALQHLDGEHAQWWQLTADFLKIASVFWPARLAELRSSAGRHRNAILRAEADANLPDTGPIIVAGSTGSIPAAADLIAAVAALPQGTVVLPGLDLAMPEEQIEDPTDPSSRTHPQYGLYMLLQKLGMSRDEVVQIGALDRDLEKRAAVFSAAL-GRDPGFFDEAFAAATLIEAANQREEATAIAVALRLALEAP---SQAALITPD-RGLARRVATELQRFGIEADDSAGTPLSATPQAGLTQLALEAILRPGDPVPIISLLKHPLARFGLSGDAF-TKASKALELIALRGGRTEIGNLEVVLDAQLLAQRDNRHPPAWRVALPEGSVDAARDLARRIAIATEPLGSAFIRRDRSGRAFTDKLPLSDWAGRTGRVIEAICADDSNDLAALWSG--EAGDKLSSLFAELMESGDILDADGPQWIDIFAALVAGESIKPRSMRHPRIFIFGALEARLQSVDTVVIGGLNEGLWPGQTANNPFLSRSMKTAIG-------EPPERRIGQLAHDFEMAN--GTRQIFYTRALRQ-GSTPAVASRWLQRLLALGG........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 732
3 -41.200[L] COG2887 RecB family exonuclease  ali follow..  15  9..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RPKHFSVTEIETLRRDPYAIFAKKILKLRPLEPLIPAAAERGTLFHDILGHFTQAAI-----------DPLAPDAAEKLMELGRILFADMDLPLEIEAVWWPRFTALIPQFLQW--ERERAYKVQERFAEIASQ---------KREVENLGITLSGRADRIDLMRDGT---AEIIDYKTGSTP-SPKQAHVLLSPQLALEAALLARGAFLDVG-PVRACDLTYVRLKAA----------------------------------------------------GEVKPESILKISRPPSEKTAPALGEEAWQRLAQLLAEYQKPEKGYLSRALPFRETDLTGDYDHLARVLE............................. 281
4 -38.800[L] COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)  ali follow..  12  27....LVAAAAGSGKTAVLVERMIRKITAEENPILLVVTNASAAEMKHRIAEALEKE-LNRASISTLHSFCLQVLKKY-DPGFRIADQTEGELIGDEVLDELFEDVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDAEMKPVIETLVQLVISYGKRFEKSIIDFSDLEHYCLAILTAENDKGEHEVLVDEYQDTNLVQESILQLVTSGTGNLFMVGDVKQSIYRFRLAEPLLFLSKYKRFTE-KNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQAELKLGAAYPDNDETETELLELETVQFEAKAIAKEIRKLISSPIQYRDIVILLRSMPWAPQIME-ELRAQGIPVYANLTSGYFEAVEVAVALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYY------------------------EAMKDYLAAGDRSDELYQKLNTFYGHL--------QKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANLRV-------------LYDRARQYESTAFRGLFRFLRFIERGDDLGTARGLSEQEDVVRLMTIHSSKGLEFPVVFVAGLGRNFNMMDLNKSYLLDKESYPTLPLIAMK-KKMRRELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQARTAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKSERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTK--------QSVSEIKRKREYEDEYSGRAPVKPADGMKKGLTAAEKGTAMHTVMQHI-----------HVPSIEEAEQTVHRLYEKLLTEEQKDAIDIEEIVQFFHTEIGGQLIGA-------------KWKDREIPFSLALPAKEIYPDAHADEPLLVQGIIDCL--YETEDG--LYLLDYKSDGFEGAAPILKKRYETQIQLYTKAV----EQIAKTKVKGCALYFFDGGHIL..................................................................................................................................................... 1230
5 -31.600[L] COG0210 Superfamily I DNA and RNA helicases  ali follow..  15  24....LIMAGAGSGKTRVLTHRIAYLIDEKFVNPWNILAITFTNKAAREMKERALAPATKDTLIATFHSMCVRILRREANRNFTIVDPGEQRTLMKRILKQLNIDPKKWN---------RSILGTISNAKNDLLDEKGYEAQAADMYSQI------VARCYKAYQEELRSEALDFDDLIMMTLRLFDANPDVLAQYIHVDEYQDTNHAQYQLIKLLASRFKNICVV----------GDADQSIYGWRGADMQNILDF--EKDYPDAKVVLLEENYRSTKKILQAANDVINNNRNRTQNADGEQLVYYRANDERDEAVFVASTISNMSQEGKNFKDFAVLYR-TNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDLIAYLTIVANPADNISFERIVNEP-------KRGVGPGTLDKLRQFAYESDQS--------------------------EAASNLLMSPLKGKAAQAIMDLANILGQLRQDLDQMSITDLAEALLEKTGYLDSL--------RLQNTLESQARIENIEEFLSVTKNFDESSASQEEDETGLGRFLNDLALIADTDDSQAEAAEVTLMTLHAAKGLEFPVVFLIGMEEGVFPLSRA----------------------EDPDELEEERRLAYVGITRAEEVLFMTNANT-GKSSYNRPTRFLKEI............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 639
6 -31.400[L] COG1330 Exonuclease V gamma subunit  ali follow..  10  7...........SNQLDLLKALTTALIEREPQEVVLVQSPGMAQWLQMQLAQQFSIAA--NIVFPLPATFIWDMFTRVDIPKESAFSKEAMTWKLMWLLPDLLENLSDDGDRRKIHQLAARVADLFDQYLVYR--PEWLESERGQLIEGLDDAQQWQALLWVELTRYTRQLEQPEWHRANLYQRFIHQLLKSDVKRVFICGISALPPIYLQALQALGKHIDIHLMFTNPCRYFWGDIQDYTFLAKLQSRKRRHYRESIELSLFRHPQQAEQLFNTDGEQNLSNPLLASW-SDQKRRLDLDDRSLSFHVCHSPQREVEVLQDHLLGLLAADLTPRDIIVMVVDIDSYTPYIQAAFGNAPLPFAISDRKASQAHPALHAFITLLDLPQSRFTAEQVLALLEVPAL---ATKFGITEDGLRRLRQWVIRWGLDDDNVREGQHTWRFGLTRMLLGYAMDSTAGDWQGILPYDESSADMLMHLSQWRQQLGQPRELSEWLPICRQLLDTFFDQDN--------------DTEAALVLIEQQWQKVIGYGIAAQYPDVVPLNLLRDELAARLDNERISQ----AGPINFCTLMPMRSIPFKVVCLLGMNDGVYPRTLPPQGLMAKKVR-----------RGDRSRRDDDRYLFLEALLSAQQQLYISYIGRSQDNSKRYPSVLVSELIEYVAQSYHLPGDEKLSADDSAQRVTQHLLCWHARMPFSA-------------------ENFIKNSELQSYAAEWLPSAESKGHAHPNFNQPLQAEPLAEI--TLDELVRFYRHPVRAFFQLRLGVPDEEPFTLDNLSRYQFNTQLLNAL-------------INEDDINSVFARARAA-------GVLPYGSFGELYWESQQDEMVPLAEQIRSERKENHSIELNIEFA------------------DITVTGWIHQV.......................................................................................................................................................................................................................... 960
7 -24.300[L] KOG2108 3`-5` DNA helicase  ali follow..  10  264....MVIAGPGSGKGLL------------PSNILAMTTKAATSEMRERIGKSAGKKAAKDITISTFHSFSLQLCRMHATSEFSVYGHGQQRRAIIEAVRLYEEEKKNGSK--------TSVPCESGEGLNGAGAGAGKAS-GKSPEQCRKMGNEIGAKILGNYNDILKADALDYHDLISCSVTLLSDFPEVFKKAIIVDEFQDTSTMQYKLLRMLGSHNH---ITIVGDD------------------------------------------------------DQITVKECHNEEAQCAYVIDKIIEITNDGSTPCCSHGDIAILYRR-------------QVSGKVFQNAFRQRKIPFFYRKKV-------VQVILAMLKTTFSECDDASYRRVFKA----LLPFEKEEKKRIIEHIEKISTSRKCS------------------SAASDIFNAKISGTFKRSQLTQGRKVLQTLDMVAKLVDREQSLSAVVTCVANMIPQKYLLEQRAVVDNDKLLNEDNDLRSVLQYLMDDVAEFISTHCTTTEEED-QLHSFINYISERETENFRSRRRDNENSVTLTTIHQANENEIPLLHESNGNASESGTSLEE-----------------------------ERRLLYVAMTRARKKLFFLYVTVQGDMSVNDCRKVHENLPN........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 827
8 -23.300[S] COG4343 Uncharacterized protein conserved in archaea  ali follow..  12  8.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LEHKFLTLELRPRIRQNPVPEELRGWNWHSNVKLPMYLI-CSRYCPTSVYLTMVEKVRGEESFPVS---LGKAIHEAVAKAIREAKS------KNFSAEPPNYDNEMINVAVKAV-------WEYTMSLCQSSYLKVRSEQPYATEEGVLLTSMPFLVEHRM--------------DGSLLGCSGLISVDCYDYLR----NVVFDLKVGEFNEE--------RLYTTGYALVL----ESIHEIPVDVGCIISITFNGERMRVSKDLHYID------------------------------------------------------------ANLRSWWIEERDRKAEIVFNEADPGVA-----KSCSSNCLFNAFC................................. 280
9 -17.000[S] KOG4760 Uncharacterized conserved protein  ali follow..  17  104................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IEESYLHRFRRNQALGVTDLTGTEWCE----KQMENVLCFGRRKVNKAMKVGQARHLQLEEEVVKKVR--------------------------------VKVESNEDKWALKLLNSIAGVNQFLFEGRTR--------ELLLGFVGG-------------QWIVGIIDELAYAEESSDSGPILIDTKTLRDTLPAEPQRRNGRLQLMLYKLLW---------DTIVKEGFPTGPFFDYFSLNRNYVLSQDVRDHIANAGIKAQTLEEIVRYYENTFQMLPIANNQLLLKYEFQKDQ------SIIAEIRFNHDHEWVMSKYREV--EFWRNEREAGYTPEEERWKCRYCQFAKSCPGNPSFESPSTSSPTREAPP............. 410
10 -16.800[L] COG1468 RecB family exonuclease  ali follow..  16  49..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DFKRLSPSVINDYEYCPRLLWTQYKLGLKLFSIDSAVAIVKGRLLHERYERAVSIFDNVIAEYKI------------------------------------------------------------------------------------EIGDLVGVVDIVMRKGNE----YIPVEIKTGLASRE------AHRRQLQIYIHMLKARY-----------GYLVYR----------------------------------------------------------------NRVEKVERDSKAVEMLYKIKSVLQM----------DKPP-----NVNCKSCPFKYIC................................. 210
11 -15.100[R] COG3972 Superfamily I DNA and RNA helicases  ali follow..  10  222...QRIRGLAGSGKTVILAMKAAHLHMTRPNDKILVT---------------------------FFTKLRSPI--------KDLVTKFYRHYKEIDPDWNN--HIRHGWGGSNSSGTYADACRRSGRMPRSYSSARDAAPRGVEPFSFACEELINSAQSLEYYDHILIDEGQDPDGFYKLCFELAKGDRDKKNIVWAYDELQNILNVKMRSPAELFDDDGEPRISLARAEKNLPPGATNDTVLSKCYRNQREVLVAAHALGFGIYSNIVVLTPDFQVGNDIEILRPVENSPVALDTDGLPPLIGNFIASSFEKEISWITKEIINFLDMGLLPEDIIVVALDMRNYFRYLSESLASHEISVNNIHADPYSEPPFSISGKITLSTVYKGNEAAVVFALGVDALSLRLRADRNKIFAAFTRTKAWLRVSGLGDSARRVAVEIDTALRNFPHLKFKMPDISEIDLIQRDLSKRSIKAKKIRNEYIQKLKDEGFTEDEIADILSLEEK.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 709
12 -10.400[R] COG3973 Superfamily I DNA and RNA helicases  ali follow..  227.KILIVQGAAGSGKTSAALQRVAYLLYRDAGQIVLFSPNFLFNSYVSSVLPELGEE---NMEQATFQEYIEHRLGRKFKCESP---FDQLEYCLTETKGGDFPTRLAGITWKAGLSFQQFINEYVTRLSSEGMIFKNIINRMEQTAKWLLSELEKMDAIGELTRSAFTDNKLLYEDAFLYMQDLIEGRKKNTKKHLFIDEAQDYSPFQMAYMRSIFPAAS---MTVLGD---------NQSIYAHTINGDQRMDACFEDEPAEYVR-----KRTYRSTRQIVEFTKAMLQADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKG--HETIAVICKTAHQCIQAHAHMSEYTDVRLIHKENQPFQKG-----VCVIPVYLAKGIEFDAVL........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 721
13 -10.300[S] COG4913 Uncharacterized protein conserved in bacteria  ali follow..  45.RSGLLTGDIGSGKST-LIDAITTLLVPAQRVAYNKAAGA---ARERSLRSYVDATGTAKPVALRGTSNYSVILGVFHNVGYDKVITLAQVFWLKDSQSQPARLFVVAERALGIAADFNNLGGDIKTLRKKLRGADSFPPYGAWFRRRFGIQHEQALELFGNLTDFVCSHMLEPCDVGSRIEALICHFDDLDRAHQAVLT----AKQQVKLLVPLVDDVQKHQ-TQLASIQALEAGRDTLRPYFAQLKG-HRLDALAAEAAQLTVEIQHLEEQRKAADSEVTQLRQALRDNGGDRLEELAAEIE--QLEQAKAQRQKKSDRYQTLLTK----IGFLTQQQRFAQHTEELNAAIERLH----KDRALYDAREKHTTLLAEINSLQQRQSNISAAQIRIRHDL----CMALSIDAEALPFAGELIQVRKEDARNW-------------------------EGAAERLLHGFGLTLLVPDAHYKAVATWVNNQQLQGRLVYFHMRPRNTTQEAALHAQALVHKLIIKPESPHYTWLQQELQRRCNVVCCDTIEQFHCEA-RAITQAGQIKDPSG----------RHEKDDRHRIDDRSRYVLGWSN-------ADKLHTLNAQRQHLEDSMGMLGQDIGTIQRECQKQQERLDALNKLGEYPEFADIDWMSLVRQIAGRKKEQEQLQATSNILQTLQQQLTAAQTQVSVLERKCKNAWHEQGEVKSQQKTAQQMWNQARSVWDDAPLSQAQITLLAGWRQQALGEHVLSVESCDNHEQQVRQWLQKRIDAENAHLRQLNDRITGAMHRFKNQFKAETVEMDADLAALPEYARMLNDLQKDDLP-----EARFKALLNVNTINEIASFNAQLNRERETITERIKDINQSLHGI--QSLHGIDSQKGRYITLLAQPSPDAEIRDFQQDLRACTE-QVKRIIDRFGLSDADRRWTAKVTDVRN---VFSASER-SGGQKEKLAYLAASLAYQFGLKWDEVRSESFRFVIIDEAFGRGSDESAEYGL--RLFQKLNLQLLIVTPLQKIHIIEPFVSS--------GFVHNKGGCDSQLRCLSIEEYQT............................................................................ 1131
14 -10.100[TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family  ali follow..  960VILPPLFPYLEPQEAELVIQIFDFISSDTHKCLIPTSLDSACFSLKAKEIFCSLQNEDFYSELQSIIK---CLTNENEPVCYLGLQK------LELFFQAKVDELHDTLNLDISNEVLDQLLRCLLDCCVGAIDPSRAKAQHIIKEDNFENGEESLKFILDFMQSQLIPAFLVTTDTKAQGFLAYALQEFLKLGGF----WMSLPDLSKRVLIPFLTSKYHLTPIPKIDIRYPIYKENVT-MQLFSLKLMEYAHSQNAEKIFGICSKVVKDQEVNIPCFLLPFL------------------VLNVILTESELEVNKVIEEFQLVINQPGPDGLNSVGQQRYTSFVDVFFKIVD---LNKWLRMRKKRNWDRRSAIARKENRYMSVE-KVESFLSRFPSKTLGIVSLNCGFHARALFYWEQHIRNATAPYAALESQEIYAGIDDPDEIEAVSLNFHDYSFDQQLLLHENSGTWDSALSCYEIIIQKDPENKKAKIGLLNSMLQSGHYESLVLSLDSFIINDNHEYSKGIEASWRS--DSLKKCLSKSNLESFEAK-LGSIFYQYLRKDSFAELTERLQPLAATAIANTGAHSAYDCYINDFSRIAETDGIVSDNLDIVLRRRILSTHLVGYEKFENTKKTAEIYLEIARISRKNGQFQRAFNAILKAMDLDKPLATIEHAQWWWHQ----------------------GQHRKAISELNFSLNNNMFDLVDEHEERPKNRKETLGNPLKGKVFLKLT--KWLGKAGQLGLKDLETYYHKAVEIYSECENTHYYLGHHRVLMYEEEQKLPVNEQSERFLSGELVTRIINEFGRSLYYGTNHIYESMPKLLTLWLDFGAEELRLSKDDGEKYFREHIISSRKKSLELMNSNVCRLSMKIPQYFFLVALSQM--------------------------ISRVCHPNNKVYKILEHI----------IANVVASYPGETLWQLMATIKSTSQKRSLRG-----------KSILNVLHSRKLSMSSKVDIKALSQSAILITE-KLINLCNTRINSKSV........................................................................................................ 1999
15 -9.870[T] COG5635 Predicted NTPase (NACHT family)  ali follow..  55....VLLGEPGVGKTHEL-KTFSDWLEGHYHLHLFL-TLAFPSILEEALKALWEESNFAIYELAPLRR-VINAVEAEGFSSDDFLKAINQRISLGFLLNTYRRHNSQFPPEQKRYEYLEGCKCLCEEVSKCRHALKETGNLDIDQRLIVAARIAAVTIFHQTYAEFFAAWYLTQRNIDLSKIKTLLYSSADSTPKL--------IPQLHETAVWLASMRDNVFQEIIKTDPDVLLQTDIPTDSELRATIVANLLMQYEEEKLFDRGFCNVRNYAKLKHSGLAEQLKVYICDSSKKEDTRRIAIDIAIEC----NLSELQGDLAKLTLCP---QPISIRVNAARAISSIGDQSTRLKLKSLALNVLPEDEQDELKAYALKAL--WPRQLTAEELFQALTP-LDWLKTQGVRCFGHPFEELGDAILLKAWE-LEGFTQVALLQWKEHQKLISHSPSLQAQFQESLLGNNQKRYALIENLVEISEIIKATQNNSILSDVFSYYFTPIELDSEEVTQLRDHYLKMKNSWNKPDLSAWWRLNREMLDLTQLPGWKEAEQATKKRIIQGAIQYIQ-QQTNIDYSWIGTNTYNFSELYGCKALQLILTEAPRTLDNFSTDKLVSLSYHHSPDEFLTTLLKLIDKENQDNNIFVIDRLEMCWDEKLENNLTEKVKDSQLKPNVFRKLLEKLIEQGAVQAKDIALSTIRNYTNSEFDSERQKALFAIKALITY-----SDPDSWNVIWEKITADVQFGREAFELAASCNLSGIKFDLTEKQIADLYMAYIVSPRDNIAFFRNNSLSQLRDKGTIEACAELERLQELPHLPWLKETLTYAQQNMRRE--TWRPFKPDKLLEFLIIPEPSNL---------DLSNQLSTIDKRTEKMEDIINNISDSTINAPVGTSGVT--------------SNNVTCSSPEKQ--KRFNWILFGVIGIIGVIATVVGIF----GIFNDVLKDSLN-PSKI---------EQQAMP................................................................................................................................................................. 1317
16 -9.250[A] COG5181 U2 snRNP spliceosome subunit  ali follow..  380............................................................................................KILRLLLKVKNGLTDQARDFGAAALFNQILPLLMERTLEDQERHLLVKVIDRILYKLDDLVRPTHKILVVIEPLLIDEDYYARAEGREIISNLAKASGLA-----------------HMIATMRPDIDHVDEYV--------------------NTTARAFSVVASALGVPALLPFLKAVCRSKKSWQARHTGVRII-----------QQIALLLGCSILPHLKNLVDCIGHGLEDEVRIMTALSLSAGIEAFDSVLKPLWSG------VQRHRGKSLAAFLKATGFIIPLMEPEYASHFTRRIMKILLREFNSPDEEMKKIVLKVVSQCASTDGVTPEYLRTDVLPEFFHCFWSRRMASDRRSYKQVVETTVVLAQQVGSRQIVERVVNNFKDESPYRKMTAETVDKVIGSLGVSEIDERLEELLLDGVLFAFQEQSVEEKVILTCFSTVVNALGTRCKPLPQIVSTILYRLNNKSANVREQAAD--LVSSITIVLKACGEEALMRKLGVVLYEYLGEEYPEVLGSILGAIKAIVSVVGMSSMQPPIRDLLPRLTPILRNRHEIDLVGKIADRGSEYVSAREWMRICFELIDMLKAHKKSIRRAAVNTFGYISKAIGPQDVLATLLNNLKV-------------------QERQNRVCTTVAIAIVAETCMPFTVVPALMADYRTPEMNVQNGVLKSLAFM-----------------FEYIGEQARDYVYAITPLLADALMDRDAVHRQTAASVIKHLSLGCVGLGVEDAMIHLLNILEESPHVINAVREGIDGIRNCIGVGPIMAYLVQGLFHPSRKVRNTYWTSYNSAYVQSADAMVPYYPHV.......................................................................................................................................................................................................................... 1171
17 -9.060[L] COG4644 Transposase and inactivated derivatives, TnpA family  ali follow..  31.DIAFVNGIPELARLGFAVQFFVQDHAAIPPDGVLYLAEQLDLQAEAVNHYDFSGRTARRHCAEILRHLGFRRLKREDRAGELCPTGQSIGAMLEHVFLWCLDRHIYGPSRKELERLVRSQRQHYLD--------SWLSGVHDRLSASTVALLEASIAEPDGQTGFNTMKGDAGQASLDNILSMTAKLAFIQKLNLPRDLLSVAGKAWVEQVSEMRRHAPARQIGLYAVYLFSREAQLTDAMVDLLIETVHKIGTRSKR-----KVVGDIAKDIERVYGKERLLVEIASASIEEPSGRVCDVIFPIVGKDKLAAIVKESQAKGALDRRIY----KVMRSSWANHYRRMLPDLLSVLEF-----RSNNTVWRPVLAALDWIRSKIDDGCRFVPAKDIPIDEVVPARWRSSVIDDDGRVNRISY-IRSKVVGADRYRNPDDDLPKDFGIRRDAYYSGLDLTPDAREFTSAVRAELERELLLLNETIPQNDLWRGENRISITPFKPSPEPKGLDAIKGEIGGRWPMTGLLDVLKETALDTGLLEAFETSASRVSLSRGMLDRRLLLCLTNAGLKRVAGATPDVSYEELLHVHRRFIHVPALREACARVNAAVWGDAGTACASDSTKVEKRATCVYSQLKRCSSSEVASMIEGVLRHYTDMEIQRQYVDSHGQSAVGFAFCRLL-ELAPRLK---------AIARQKLAVPEATIRARLPNLLPILSGAISWDEIEQQYDEMVKYTAAMQTRTADPEAILRRFARAEVMHPTYKALSE--LGRAVKT-------------IFLCRYLRQETFRREIH-EGLNVVENWNS-ANGFVFFGKGGEIATNRLDEQEISALALHLLQASL------VYVNTRMLQTVLVEPKWAGRMTPEDYRG------LTPLIYS--------------------HVNPYGRFD............................................................................................................................................................................................................................ 966

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L, Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H, Xu F, Salvesen G, Godzik A.; RIKEN GER Group; GSL Members. Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res. 2003 Jun;13(6B):1376-88.