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Query: [R] COG3972 Superfamily I DNA and RNA helicases, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSIDILVTTDRLNKDPLGREFISYIESNSDRLNLAGSALYYDFPAYSDYDTVTHKPDVLILSPAHGILAIRLINLARLNQGALSQADESLNQFCSILIGRLLKSKPLREGRSKLSFEVTPVIYCDQKTDVLPEDLDCELVSSYGAFEALIEKLKDRESNAETLSEIRSVLEGAKALTRASKRIVEDPEVTPAAAALAKLESEIANFDQKQRRAALVTIDGPQRIRGLAGSGKTVILAMKAAHLHMTRPNDKILVTFFTKSLRSPIKDLVTKFYRHYKEIDPDWNNIHIRHGWGGSNSSGTYADACRRSGRMPRSYSSARDAAPRGVEPFSFACEELINSAQSLEYYDHILIDEGQDFPDGFYKLCFELAKGDRDKKNIVWAYDELQNILNVKMRSPAELFGQDDDGEPRISLARAEKNLPPGATNDTVLSKCYRNQREVLVAAHALGFGIYSNIVQLLESPDHWRDVGYDVLTPDFQVGNDIEILRPVENSPVALDTDGLPPLIGNFIASSFEKEISWITKEIINFLDMGLLPEDIIVVALDDRHMRNYFRYLSESLASHEISVNNIHADPYSEPPFSISGKITLSTVYRAKGNEAAVVFALGVDALSLRLRADRNKIFAAFTRTKAWLRVSGLGDSARRVAVEIDTALRNFPHLKFKMPDISEIDLIQRDLSKRSIKAKKIRNEYIQKLKDEGFTEDEIADILSLEEKDELast
1 -168.000[R] COG3972 Superfamily I DNA and RNA helicases  ali  100  1MSIDILVTTDRLNKDPLGREFISYIESNSDRLNLAGSALYYDFPAYSDYDTVTHKPDVLILSPAHGILAIRLINLARLNQGALSQADESLNQFCSILIGRLLKSKPLREGRSKLSFEVTPVIYCDQKTDVLPEDLDCELVSSYGAFEALIEKLKDRESNAETLSEIRSVLEGAKALTRASKRIVEDPEVTPAAAALAKLESEIANFDQKQRRAALVTIDGPQRIRGLAGSGKTVILAMKAAHLHMTRPNDKILVTFFTKSLRSPIKDLVTKFYRHYKEIDPDWNNIHIRHGWGGSNSSGTYADACRRSGRMPRSYSSARDAAPRGVEPFSFACEELINSAQSLEYYDHILIDEGQDFPDGFYKLCFELAKGDRDKKNIVWAYDELQNILNVKMRSPAELFGQDDDGEPRISLARAEKNLPPGATNDTVLSKCYRNQREVLVAAHALGFGIYSNIVQLLESPDHWRDVGYDVLTPDFQVGNDIEILRPVENSPVALDTDGLPPLIGNFIASSFEKEISWITKEIINFLDMGLLPEDIIVVALDDRHMRNYFRYLSESLASHEISVNNIHADPYSEPPFSISGKITLSTVYRAKGNEAAVVFALGVDALSLRLRADRNKIFAAFTRTKAWLRVSGLGDSARRVAVEIDTALRNFPHLKFKMPDISEIDLIQRDLSKRSIKAKKIRNEYIQKLKDEGFTEDEIADILSLEEKDE 711
2 -50.300[R] COG3973 Superfamily I DNA and RNA helicases  ali follow..  12  196............................................................................................................................................................................................EVLSHHSDTQMKNIVSTIQKEQNQIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGGQIVLFSPNFLFNSYVSSVLPELGEEETKGGDFPTRLAGITWKAGLSFQQFINEYVTRLSSEGMIFKNTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFP----AASMTVLGDINQSIYAHTINGDQRMDAC----------------FEDEPAEYVRLKRTYRSTRQIVEFTKAMLQD-----------------------------------------GADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKG---ETIAVICKTAHQCIQAHAHMSEYTDVRLI----------HKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLYTACTRAMHMLAVFYTGEASPFVTAVPPHLYQ............................................................. 771
3 -35.900[L] COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)  ali follow..  14  1...................................................................................................................................................................................................MNIPKPADSTWTDDQWNAIVS-TGQDILVAAAAGSGKTAVLVERMIRKITAEENDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHISISTLHSFCLQVLKKYKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAEPLLF----------LSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQAELKLGAAYPDNDETETELLLIDNAED---------TDASEEAEELETVQFEAKAIAKEIRKLISSPIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTS-DDLGTARGLSEQEDVVRLMTIHSSKGLEFPVVFVAGLGR-RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQ............................................................ 900
4 -33.700[L] KOG1803 DNA helicase  ali follow..  12  239.............................................................................................................................................................................................................LNPSQVAAVSAAMNTQRCIQGPPGTGKTRVIAEIVHQLMKK--KKKVLVCAPTHVAVRNAMDATTGRMIEEMPEEKAEQQLCLLANTKDEFQNHKSASKLEEIKKQLSTMSTSDPLYKKMSYEYYLIRNSIFRSPEYHWNADVMIVDEAQCTEPATW------VLTTPSCKKLILVGDQKQ-LPAVVLSDKAMKGNFKLSLMEKLAEEFSSNNIN------ILLNEQYRMNKKIMNWSNEVFYE---------NQLTAHSTVSDITLRDICPNLPEDHVLNNPIMMINMENVKDRSHEEFESHSFTNTDELNLVTEYVNRLVVDGINPKAIAVISPYYAQIEKLRRSIPF--------------------------RVDVNTVDAFQGHERQVVIFCLVRDNDEGFLNETRRLNVAVTRARRQFVLIGNGRMMNKHLLKLYKHLQSEKVIFGPSILETFNDLEEAALPRSDK.................................. 692
5 -33.600[L] KOG2108 3`-5` DNA helicase  ali follow..  16  231.............................................................................................................................................................................................ALLNSMPDECSKYMLSLNDRQRDAACSNISTPLMVIAGPGSGKGLL--------------SNILAMTFTKAATSEMRERIGKSAGKKAAKDITISTFHSFSVYGHGQQRRAIIEAVRLYEEEKKNGSSPEQCRKMGNEIGAKILGNYNDIKECQDTWKAIIVDEFQDTSTMQYKLLRMLG----SHNHITIVGDDDQITVKECHNEEAQCA----------------------VIDKIIEITNDGSTPCCSHGDIAI---LYRRQVSGKVFQNAFRQIPFNVHGVAFYRKKVVQISGTFKRSQLTQGRKVLQTLDMVAKLVDREQSLSAVVTCVANMIPQKYLLEQRAVVDNDGGKLLNEDNDLRSVLQYLMDDVAEFETENFRSRRRDNENSVTLTTIHQANENEIPLLHESNGNASGTSLEEERRLLYVAMTRARKKLFFLYVTVDSRKVHENLPNKTEQSVSSFGTDIKHEESKLTDNDVMNIPEDYAS.............................. 861
6 -33.300[L] COG0210 Superfamily I DNA and RNA helicases  ali follow..  17  1......................................................................................................................................................................................................MNPLLNGMNDRQAQAVQTT-EGPLLIMAGAGSGKTRVLTHRIAYLIDEKNPWNILAITFTNKAAREMKERALALNPATK-------DTLIATFHSMCVRRSILGTISNAKNDLLDEKGYEAQAADMYSQIVARCYKAYQEEAYYQQRYQYIHVDEYQDTNHAQYQLIKLLAS---RFKNICVVGDADQSIYGWRGADMQNILDFEKD-----------------DAKVVLLEENYRSTKKILQAANDVINN------------------------------------NRNRRPKKLWTQNADGEQLVYYRANDERDEAVFVASTISNMSELGKNFKDFAVLYRTNAQSRTIEEALLKSNIPYTM-LNDLALIADTDDSQAEAAEVTLMTLHAAKGLEFPVVFLIGMEE-PDELEEERRLAYVGITRAEEVLFMTNANTRTTRFLKEISE................................................................ 641
7 -33.100[A] KOG1804 RNA helicase  ali follow..  14  309............................................................................................................................................................................................................VLNENQKLAVKRILSGPYILFGPPGTGKTVTIIEAVLQVHFALPDSRILVCAPSNSAADLVCLRLHE--------SKVLQPATMVRVNATCRFEEIVIDAVKPYCRDGEDIWKASRFRIIITT---SSSGLFYQIGVRVGHFTHVFVDEAGQASEP--ECLIPLGLMSDISGQIVLAGDPMQ-LGPVIKSRLAMAYGLNVSFLERLMSRPAYQRDENAFGACTKLVKNYRSHEALLMLPSRLFYH---------------RELEVCADPTVVTSLLGWEKLPKKGFPLIFHGVRGSEAREGKSPSWFNPAEAVQVLRYCCLLAHSQVSASDIGVITPYRKQVEKIRILLRNVDL----------------------MDIKVGSVEEFQGQEYLVIIIFEDDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHVLVRFGALLEYSITNGVYMGCDLPP------ALQSLQNCGEGVADPSYPVVPESTGPEKHQEP............ 775
8 -32.900[A] KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1)  ali follow..  14  409.............................................................................................................................................................................................................LNSSQSNAVSHVLQRPSLIQGPPGTGKTVTSATIVYHLSKIHKD-RILVCAPSNVAVDHLAAKLRDLAKSREDVESSVSNLALHNLVGRGAKGELKNLLKLKDEVGELSASDTKRFVKLVRKTEAEILNKAAGDKRLDTKFRTVLIDESQASEPE------CLIPIVKGAKQVILVGDHQQ-LGPVILERKAADAGLKQS-----------ERLISLGHVPIRLEVQYRMNPYLSEFPSNFYEGSLQN----------------GVTIEQRTVPNSKFPWPIRGIPMMFWANYGREEISANGTSFLNRIEAMNCERIITKLFRDGVKPEQIGVITPYEGQRAYILQYMQMNGSLDKDLY----------------IKVEVASVDAFQGREKDYIILSCVRANEQGFLRDPRRLNVGLTRAKYGLVILGNPRSLNTLWNHLLIHFREKGCLVEGTLDNLQLCTVQLVRPQPRKTERPMNAQFNVESEMGDFPKFQDFDAQSMVSFSG 890
9 -26.900[L] COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member  ali follow..  14  3..........................................................................................................................................................................TCGRRLAARLTSFVGWPAKSALAPGGRILTLKVMQFAPQQDEALKAVRSQLFRLFGYAGTGKTTLARHFAENV-----DGEVVFAAFTGKAAQVLRSK----------GATNAKTIHSLIYR----------------------PRGEEEVEDEETGKTSIAPMFAINRQSPVAKAALIIVDECSMVDEALGKDLMSF------GTPILVLGDPGQ--------------------------PVSGGGYFTNHEPDFLLTDIHRQARDIIQLAMQVREG------------KEIMHGDYGTAQVISKGQVTQPLVLEADQVLVGTNRTRRRYNQRLRELKGFTSEYPQSGDKLVCLRNDGLLNGSLWQVMSSSKETVKPGINLMIRPEDDDMDRGAAKIKLLKAAFEDVEGEIPALTVHKAQGSQWNNVVLFDESWAFR--DTRERWLYTAITRAAERLTIV............................................................................... 409
10 -21.700[L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits  ali follow..  12  370...........................................................................................................................................................................................................YILDSSQKAYQSMLTKRLSIIQGPPGTGKSFVTLKAIETLLENTHVLPILVACQNHAVDQILIRLLHRLGSRTKDPEIAAVTIIIYCRWLESAYAAAEKELNRLYRFYLKVDRERIGFSNKRAAILLRGANVIGMTTTGLNKYKICFIEEAADVLEG--PIIPAVFPS----EQLVLIGDHKQALRQDPFNLSISMF----------------ERLVENDMEYTRLTMQRRMHPQIRRLVSSVYEDLSDYEIT-----------------------KYWPSIPGMGEIRRFFLTHSRIEDNDGFASKINLFEAQMLVQFAVYLINNGVEPQKITCLTFYAAQKDLIERLLSESLNREK-------------------HFIKVATVDGYQGEENDVVLLSLVRNNDRGFLSSPHRVCVSLSRARRGLFIFGNAQLVAESNPLWWDAINTLMN......................................................... 961
11 -17.600[V] COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases  ali follow..  258...........LSEEESRFLIDAQLRKAGWQADSKTLRFSKEWPTGKDETGNQGFADYVLFVGLKPIAVVEAK----RNNIDVPARLNESYRYSKCFDNGFLRETLLEHYSPDEVHEAVPEYETSWQDTSGKQRFKIPFCYSTNGREYRATMKTKSGIWYRDVRDTRNMSKALPEWHRPEEEMLGSEPQKQNQWFADNPGMSELGLRYYQEDAVRAVEKAEILLAMATGTGKTRTAIAMMFRLIQSQRFKRILFLVDRRSLGEQALGAFEDTRINGDTFN-------------------------SIFDIKGLTDKFPEDSTKIHVATVQSLVKRTLQSDEPVARYDCIVVDEAHRGYILDKEQTEGELQFRSQLD----YVSAYRRILDHFDAVKIALTATPALHTVQIFGEPVYRYTYRTAVIDGFL-IDQDPPIQIITRNAQEGVYLSKGEQVERISPQGEVINDTLEDDQDFEVAD-------------------------FNRGLVIPAFNRAVCNELTNYLDPTGSQKTL-VFCVTNAHADMVVEELRAAFKKKHDAIIKITGDADKDARKVQT-NIVVTVDLLTTGVDIPSI-IVFLRKVRS------RILYEQMTRNKTSFKIF-VVRPKVELQTLVNEITDSETYKITEADGRSFAEHSHEQLVAKLQRIIGLATFNRDRSETIDKQVRRLDELCQDAAGVN 956
12 -17.000[S] COG3421 Uncharacterized protein conserved in bacteria  ali follow..  55.............................................................................................................................................................................................................FFEWQKSALENF--THLLFNMATGAGKTMMMAALILYYFEKG--RHFLFFVNQNNIVDKTENNFIDPAHAKF-------------------TEKILQGDTVIPIRKVEMFSPHSDGIEIKFTSIQKLYNDIHTERENQTTLAVMLGDEAHHLNAQTKGKKQDELDLEVELKANAGNAEIERKGWEHMVLELLLNKNGNPGQNVLLEFTATLPENADVQQKKEFLQKGYTKEINLVSSTLNKKERVLHALLFAWYRHQIALKYGIANFKDESKADYSAFLNWAENVQADDFEFLDTFSGSLNNSDNANEQGKTRTEQALKFMQDNKFGFAHLANWVKQNYQKHNVIITNSETNKNKTEKTDSETEKLLNNLEAADNPRAIFTVDRLTEGWDVLNLFIVRLYEGQNGGGSNKKSGKTAAATVS--KQLIGRGVRYFPFAFEGKQPNKR----KFDNDMQHELRILEELFYYTHDEQSRYISELKNELRKDGYLPEKDDDKVLATFKLK 584
13 -15.600[T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase  ali follow..  14  121..............................................................................................................................................................................................................TLGQKHYVDAIDTNTIVFLGPAGSGKTYLAMAKAVQALQSKQVSRIILT-----LPGTLNEKIDPYLRPL-------------------------------HDALRDMVEPEVIPKLMEAGIVEVAPLAYMRGRTLNDAF--VILDEAQNTTPAQMKMF---LTRLGFGSKMVVTGDITQ..................................................................................................................................................................................................................................................................................................................................... 272
14 -15.100[L] COG3857 ATP-dependent nuclease, subunit B  ali follow..  10  4.............................................................................................................................................................................................................................QIIAGKAGTGKTTHLMDEVGEKIKKTSKTYIFIVSFSR-LAWKIKTFLSQTGIEMVIRKAALDQ-KLKIFSRATSKKGFYSELAKLFKEMKQEEISVDELEKSAANLSTSVSSKVHDISLIYQKYEELLAGKFLE-NEDYLRLLADKIIESDYLNQTEIIIDGFTSFSKQELTVIEKLM--QKCDKVTVSLTLNVPEIHKGLEDFSMFKASTEAYFALLEMAKLNKIQVEPEKI---------------LLENKRANSDSLAFLANAWGDNKYSSYEGGANDLTIHQANNRRAEMEGVAREIRQLALNGYRYRDIAILTRN---IGDYDILCETVMESFDIPIFIDKKRAMAKHPFIEFIRSSIDAIL--FNWKYEPIFQAVKTEFFFDVAENATIMRRKADILENYVLENGIQNKWKWEKEGDWIYRKIRGLSTNVLPQTDEELATQSVINEMRNLIVEPLSTLENNITKAKTGIEFAMALYHYLEQ.. 503
15 -15.000[KL] COG1061 DNA or RNA helicases of superfamily II  ali follow..  77...........................................................................................................................................................................................................MEPYPHQSEALAAWKLAGRVVVLPTAAGKTYLAQLAMQAT-----PRTTLIVVPTLDLMHQWYAHLVAAFPDAEVGLL------------------------------------GGGSRDKSPVLVATYDSAAIHAEALGNQYALIVFDECHHLPTDFSKVIAEYAIAP--------------------------RLGLSATPERTDGKHADLNILIGQEVYRKRAEDLAGKA--AEHEIVQIKVKLSQQERERYNNLIQIRNDFLRQSKVSLGSIQGWQMFVQMSARSQSGRRAMLAHREAKEIALGTDSKLRILANLLAK------YPERVLIFTADNATVYKISQDLLIPAITHQTP----VKERHEILTKFREGEYNTLVASHVEGVDVPAIILSGTGSTREYIQRLGRILRKGNIQNKQAILVIAEDTSEENTSARRRGEDKKANL-QVVYGSGKGTTAKAAEQIEINYVVDNSSANNQGNATNGTPQPSPKRRRNNTKKTED 517
16 -14.900[L] COG1111 ERCC4-like helicases  ali follow..  11  21.................................................................................................................................................................................................................QQLLAADVIRKGNSM---TALGKTVVAVLVAAERLRKYRGSKVLILSPSKPLAIQHEESFREFM-----------LATCTSLTG---------------SIKPEERKERWIKSQIISATPQTVESDILAGRYDLRDVSLIVFDECHRAVGSYVFLASNYIQNARHPLILGLTAEGDPDVRPYLKPIKIEWVKVRMTPE-RELLRKVLKNRLKMLKNLGVIDTISVGKKDLLKARGRVQNRIARSTSPPRACYRAISLLASCINVEHALELLETQGIRPLHQYLLRLKEKKTKAAKGLLADPDFTRAMHLTLDRLMEILKRELKGDEIIVFTQFRDTLEEIYQRCKREGINAVKFYGQNSRSGEKGLTQKQQRDVLLSTSVAEEGIDIPSVLVVMYEPVPSEIRMIQRRGRTGRKRKGRMVVLITEKTRDE---AYYYSSIRKERSMKENLRGGSVNVEVNPIMEPSGEGPF............................... 519
17 -14.700[V] COG3587 Restriction endonuclease  ali follow..  11  1.....................................................................................................................................................MSGFNYEKNQPHQMRAVSAVLGVFDGATPKYRTADENPELLFAAKQYANNILKVQSQNGIDGRFPDRSDDQNILISMETGTGKTYTYTQTMFELHRWLGVFKFIVVVPTLSIKAGTQQFLQEHFEQDFGGDYEGVRLKTYVVESAKKNKGKKSNAPITIEQFVKAENKKE-NAGMVNSSSMNDTGDKALKDLFDNPVDAMIVDEPHKFPTRDSAKTWGNIKRNDEYYNLLYRLTANDGLVKGVRVFQEEMQGGMDAAVKLVSSDGKEAKFELNEKDKKQTFKLAKGEKTVVVLSNGLELKTGAVINPYSYSQTVQDAMMQRAVAEHFKLERALLAERAPQPKIKPLTLFFIDDIAGYRSGNELSGSLDKFESWIRAEAARRLKTESDPFYRDYLQKTLDDVSACHGGYFSKDNTDSDDRIEQEINEILHDKEKLLIFSKWTLRGWDNPNVFQICKLRSSGSTTSKLQEVGRGL-RVPYKLNYF-VDSSEKDFVKQLVGEINDNSFQEEISKKFTEELKQKILQKYPDIKPLVLVNQLFLD...................... 613
18 -14.500[V] COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases  ali follow..  79LVGAGGVGSIPITRDDGSSLEVEIFYEDDVAGGRSRYEIVNQVRF-SEGLTTKRIIDVALLINGIPVVHIEEKD---EHLQNQWRAFEQLKGYHGDYKGLFAFVQVQVIMSQHSAHYFARPNAFEQYNKTFVFGWRDENNKDITDAFEFIHQVMSIPALHRLVTVNM---------------------------IPDASNDNIMVMRSYQIQATREILQRMKYIWHTTGSGKTVTSFKVAQLLASAPRIKNVLFIVDRIDLIDQTLENFKSF-------------------------------------------AYAHFKNRIKKVNGRELKRELKRKGS-----SQILLISVQGLTKA---------KGLENDDWNVIIMDEAHRSVKLIKKALKKTTWFGFTGTPNFYSDEINDVKTTREISTHDI---FGKRLHTYTIKDAIGDGNV-----------------LGFDVTYFKPHWVVEHPQEDFSEKDYEKEVYQSDVYRQEVVKDILDNWTKTSSGALIAGKREENAFQAMFAVSGKQAAVNYYNIFKSKGSHLNVAMTFSRDESNEHGTKEQNEDLVIVSDQLLTGFDSKFINVIYMDK-------KEGMLIQAISRTNR-RFYRQGDEMREFVENALRIYTRGGND-TLQEAEEETKNQLPKDLENDDILAKPQSHQINELEEAVLRLKELAGDDFSQVPRGQ 762
19 -14.300[KL] KOG1123 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 3`-5` helicase subunit SSL2  ali follow..  10  330...........................................................................................................................................................................................................AVLRPYQEKSLRKMFGNGRARSGVCGAGKSLVGVTACCTV-----RKRALVLCNSGVSVEQWKQQFKMWSTADDSM--------------ICRFTSEAKDKPMGCGILVTTYSMITHTQKRSWEAEQTM------RWLQEQEWGIMVLDEVHTIPAKMFRRVLTIVQSH--------------------------KLGLTAT---------------------------LREDDKIADLNFLIGPKLYEANWLELQKKGYIARVQCAEVWCPMSPEFYREYLTTKTSK-------------KMLLYVMNPSKFRSCQFLIKYHEQRG---DKTIVFSDNVFALKHYAIKMNKPFIYGPTSQNERIQILQNFKFNSKVNTIFVSKVAD-TSFDLPVLIQISSH------GGSRRQEAQRLGRIAIAEEYVSQDTMEMSYSRKRQRFLVNQG-YSYKVITHLKGMDTDSDLMYGTQEEQGQLLQLVLSASDLDCEDEKLPGEP....... 750
20 -13.700[L] COG4098 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein)  ali follow..  10  94............................................................................................................................................................................................................QLTPFQEKVSEGLKQKPTLVHAVTGAGKTEMIYQVVAKVINA--GGAVCLASPRIDVCLELYKRLQQDFS---------CGIALLH---------------------------GESEPYFRTPLVVATTHQLLK-----QAFDLLIVDEVDAFPYVDNPMLYHAVKNSVKENRIFLTATSTNELDKKVRLGELKRLNLPRRFHGNSDFNRYLDKNRLSPKLKSYIEKQRKTAYPLLIFASEI-----------------------------------------------------------------------KKGEQLAEILQEQFPNEKIGFVSSVTEDRLEQVQAFRDGELT-----------------------ILISTTILERGVTFP-VFVVEANH---RLFTKSSLIQIGVGRSMDR-LLFFHDGLNASIKKAIKEIQMMNKEAGL...................................................... 432
21 -13.600[R] KOG0354 DEAD-box like helicase  ali follow..  77.................................................................................................................................................................................................................QFNIVQKALFENVLVALPTGLGKTFIAAVVMMNYLRWFPKSYIVFMAPTKPLVTQQMEACYKITGIPKSQTAELSG-----------------------HVPVTTRNQYYQSRNVFFVTPQTILNDIKHGICDRTRISCLVIDEAHRSTGNYVEVVHLLSLSNKNFRILALSAEAIQNVIDSLHISRIEIRTENSIDISQYVQKKEVDFFPVDLSAEIT-----DIRDRFSSILEPMLQKLNKGNYYRIQNAKDITSFTVVQAKQAFLAVGRSGYKKRIINHENYRPLMDDIEILLRDQSFVGHPKLEHLERIVTEYFEKEQTKDTRIMIFVEIRSSAEEILRFLGKFYPNVRPAIFIGQSAVRKAAGMSQKNTLIATSIGEEGLDIGEVMIICYDASASPIRMLQRMGRTGRKRKGYIYMLLTRGKE----EAKWERAKDAYRTLQDNIVSGRGLSLSEKSYRILPEKFRPVCDKRVIEIPKENEEVVVAPKKVQLRTKIK 620
22 -13.400[T] COG1875 Predicted ATPase related to phosphate starvation-inducible protein PhoH  ali follow..  14  252..............................................................................................................................................................................................................SAEQRVAIDLLNDDAVGIGGPAGTGKSALALCAGLEAVMERRIQRKIIVFRPLFLPGDQEEKMGPWAQAV-------------------------------FDTLSSMVSQNIIDEALSRGLIEVLPLTHIRGRSLHDAF--VIVDEAQSLERNVLLTM---LSRIGQNSRVVLTHDVAQ..................................................................................................................................................................................................................................................................................................................................... 407
23 -13.000[R] COG1783 Phage terminase large subunit  ali follow..  1...................................................................................................................................................................................................MVEANVVDLVVNPHFEEYVFDWTQKTFLAVGAYGSSKSYATAEKIIIKLFEEKRKCLVVRDVHESHKDSTFALLTEILEEMGVVGRGKRKVVI-------TQSPMKIKFPNGSSIIFKGLDKPSKLKSI-------------------ANISIIWVEECSEISYAAYKELLGRLRHPFLKTHIILTSNPVSIVYLH-------FFEDFINKRFILSDSLLYEKRIIKKNNTYYHHSVAEDNYFLTQDYIDDLEDMKNYDPDLYRVAGVLGTKVLPQLEEKDHDWMIEAINNIKNPINRNGMDFGFVESMNALLSMTIDPDKKDL--IHFEYYANGNTDDVTAQDIKEDSAEPKTIKYFSDNGFVMYAAHKFPGSRLQNTKKVKRFRHIYVSSINELKHLTFA-----LGKTIEDEFNIDPHTFYGLDGYEVA.................................................................................... 423
24 -12.300[DL] KOG2035 Replication factor C, subunit RFC3  ali follow..  27................................................................................................................................................................................................................NHLKFLSADCMPHLLFCGPSGAGKKTRIKCLLRELYGVGVEK---------------------------------TQLIMKSFTSPSNKKLEIQTVSSNYHIEMTPSDVGIYDRVVVQDLVKEMAQTSQIESTSQRSFKVVVLCEADSLTRDAQHGLRRTMEKYANNCKIVLSCESLSRIIEPLQSRCIIINVPAPTDEDVTKVLRKVIERESFLLPENVLQKIVEKSEGNLRRAILMTEALRMENESGVAESVVIPVPEWEIY---------------------------IQETARLILQKQSSDMLLKVRERLYELLSRCIPPTVI-FKKLLEHLLPKCPPQIAREVVSEAAKFEHRLVLGQKAIFHLEGFVAAFMDIYLTNASKPK.................................................................................................................. 354
25 -12.100[A] KOG0350 DEAD-box ATP-dependent RNA helicase  ali follow..  10  153.................................................................................................................................................................................................................QAAVLPLLLQDGRHVCVSAGSGKTLSYVIPIVQCLSHRTVPRLVVIVPTRELTVQVAKTFEYYMSG--------AGLQVCAWTGQKSLRHETYQLNG---------DENECRIDVLVSTPGRLVDHIRNDESFSQHLRYMVIDEADRL-QDWVDTVMMEISHPKCLQNKSNILDLDQNISPTFLPDIDTLLPYRLPSPLQ------------------KLVFSATLTRDPSKIASLKLHNVQNKDMEVDDGGEIEDDAIVFSVPPTLQEYHVSVSSEKPILLYHLIHSKNLTNILCFVKSNEAAARLHRLLELIHESLNQSFSCGLF----LSRDERKKIISRFATGDLN-----------------------LLVCSDLMARGIDVANTNVINYD------LSVRSYVHIGRTRAREGFAWTLVQSHEGHHFSKLVKQLRR----------TLPIKRIKIEFSHISEEFVVAYDKALEALRVEVFNSRYPQQ......... 599
26 -12.100[A] KOG0348 ATP-dependent RNA helicase  ali follow..  12  54..............................................................................................................................................................................................................TLVQAQAIPVILSGRDVLNAPTGTGKTIALIHHLQGHVDRSHGTFALVIVPTRELCLQVYETLEKLLHRFH-------WIVPGYVMGGEKKAKEKARLRKGISILIAT----------------RLLDHLKNTASFVKNLRWVIFDEADGYGKEIEQIIKLLGSGQNEQGE--------------------------------------EDDIVPKGIQKQNLLLSATLNDKVNDLAK---LSLDDPVMIGLDNTKLQQNLSIESPAAPDSDAEDMVIHVNKSANPLSEDYGIPSQLVQRYLRVPCGARLVALLSVLKNLFERE-ASQKVVVFFSTRDAVDFHYSLLSEFQWPPN-SMEQEDRRSAFGTFKTEKQAVLLSTDVAARGLDFPKVCIIQYD------GEATEYVHVGRTRIEKGEALLFLQPIEIDYLKELKKHGASLTEYPLMLDKFPIPGNMPRIKKVLSLESHPWVISLQRALESLTYAEPKMKSLAKN..... 527
27 -11.700[A] KOG0329 ATP-dependent RNA helicase  ali follow..  11  69..............................................................................................................................................................................................................SEVQHECIPQAILGMDVLQAKSGMGKTAVVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMP-------NVKVAVFFGGLSIKKDEEVL-------------KKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQMRRDVQEIFRMTPHEKQVMMF--------------------------------------------------SATLSKEIRPVCRKFMQD------------------------------MEIFVDDETKLTLHGLQ--------QYYVKLKDNEKNRKLFDLL-----DVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDRILVATNLFGRGMDIERVIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNIS---ELPDEIDISSYIEQTR...................................... 428
28 -11.700[A] KOG0326 ATP-dependent RNA helicase  ali follow..  10  109..............................................................................................................................................................................................................SPIQEESIPIALSGRDILRAKNGTGKSGALIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMG-------GAKVMATTGGTNLRDDIMRLDDTVHVVIAT----------------RILDLIKKGVAKVDHVQMIVLDEADKLSQDFVQIMEDIILTLPKNRQILLY--------------------------------------------------SATFPLSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYV---------------------------------------TERQKVHCLNTLF-----SRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNRNLVCTDLFTRGIDIQAVNVVINFDFPKLAET-----YL-IGRSHLGLAINLITYDDRFNLKSIEEQLGTEIK---PIPSNIDKSLYVAEYHSEPVEDEK.............................. 471
29 -11.400[A] KOG0340 ATP-dependent RNA helicase  ali follow..  12  82..............................................................................................................................................................................................................TPVQTHCVPKILAGRDVL-GLAGSGKTAFALPILHRLAEDPYGVFALVVTPTRELAFQLAEQFKALGSCL--------NLRCSVIVGGMDMLTQTMSLVSRPHIVITTPGR-----------IKVLLENNPDVPPVFSRTKFLVLDEADRLDVGFQDELRTIFQCLPKSRQTLLF--------------------------------------------------SATMTSNLQALLEHS--------------------------------------SNKAYFYEAYEGLKTVDTLTQQFIFEDKDAKELYLVHILSQMEDKGI--RSAMIFVSTCRTCQRLSLMLDELEVENIAMHSLNSQSMRLSALSKFKSGILLATDVASRGLDIPTVLVINYDIPRDPRDYVHR---VGRTRARGGLAVSIITETDVKLIHKIEEEVGKKME-PYNKKVITDSLEVTKVSKAKRVAMMKMLDN.......................... 456
30 -11.400[L] COG1110 Reverse gyrase  ali follow..  11  89.................................................................................................................................................................................................................QRTWVKRILRGKSSIIAPTGMGKSTFGAFISIYFAIK--GKRSYIVVPTTPLVVQTVKKIQDMMERAG------VNVRLVYYHGNLKK-----------KEKEEALKRIKDGDFDILVTSSQFLATRFDELLRDKRFDLIFVDD-----------VDAFLKASKNIDRSLLLLGFTQEVINRAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIIVASATGSARGDRIKLYREL--------LGFEVGSGRSVLRNIVDTY-----------------------IIPERSIEEEVENLLRKLGKGG-------LIFVPIDKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYATYYGVRGLDLPHLI--------------RFAVFAGVPKFRFSMDLEQPTIRVLGLMSEILEFLPQEKREEGE----KLYARLRRLIRNIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVE.. 513
31 -11.400[S] COG5323 Uncharacterized conserved protein  ali follow..  13  5....................................................................................................................................................................................................ARGKSWAVGLAFRQILAAQLPPDGDWRIMGGRGSGKTRAGAEWVSGMALGKPSGHIALVGET---FNDAREVMVD----------------------------GPSGILSVSRLVRPRYEASRRRLIWDNGAVATLFSSEDPDSLRGPQFDAAWCDELAKWKNP-WDMLQFGLRLGDNPRQVVTTTPRAVPLLKALLTDRTVSMTHMRTAENAGNLAEGFMQTIARRYAGTRLGRQELDGELVEERPGALWSRDRIEQCFEENPPPLAR-VAVDPPASSGKASDACGIV--------VAGIDAEGVGHVLADESMTMAKPHQWARRAIALYHT----EADAIVAEVNQGGEMVAAVLAAEDPSVPVLKRRASRGKWLRAALYEQGRVRHAG--RFPALEDEMCDFAPEGLSSGRSPDRLDALVWALGELML.................................................................................... 418
32 -11.400[R] COG1203 Predicted helicases  ali follow..  18.................................................................................................................................................................................................................QKEAMDNLLEGKSIIRAPTGAGKTEASLIPFIYGLNDYLPPQLIYSLPTRTLVESIGERAIKYASF--------KKLRVAIHHGKKATSSLFEEDIIVTTIDQTAGAYLSVPLSMPKRWGNIFVGGIASA--------LTVFDEVHTLDPEKGLQTAAAIA---------------------------------------------------------MQSAKLGLP--SIIMSATLPDVFIERVKERIEKNGG--------------------KVEIMDVKNESEIKSRRNRKVELINRPDEMLTADTVLKEAEN--------RKLVVVVNTVERAQNLYLDLRKKIDYPIFLLHSRYLEKDRAEKEKSGECIFISTQVIEVGMDISSPIILS------------DALIQRAGRGEFHVFGLARDSSLKELIESTITEIRSKGDFPLDWQTELQLVNNVLSSHFEFFMDSKFFYQRLGELARAVYEKAKVEQNVREIFSCD 436
33 -11.200[R] COG4889 Predicted helicase  ali follow..  1MSTIAVSALRTLPSQSAQGLAFEKLMVNFPTLSTEFDEVHRWVDWPYNGGTMDTGIDLVAYNKDDDYTAIQCK-----YLPTTSLAKGQLDSFFEASGRTFETPEGTRSFSNRL------------------------VISTTDKWSSNAEKMLENQTIPTNRIGLSAIAESPIDWDIAYPGSELTINLQLKEP---------YSPRPHQQTAIEKAIEGRGKLIMACGTGKTFTALRLSEEVARLNNKARILFLVPSISL---LSQTLKEWTAQ---KTMDLRPVAVCSDSKVSKAAEDIAAYDLEVPVSTDGALIAEKLEHRKRAAGLTVVFSTYQSLPAVHAFDLVICDEAH---------TTGITLAGEDPSNFTRIHDAAKRLYMTATPRLFD--SVKGKAADHSAEVSSMDDEAIYGPEFHRLGFGEAVEKGLLTDYKVVVMTVDEQVAASALTVLG-EELTLDMTSAIIGAWNGLAKRSGKEQDTKTGFSSSDAAMERAVAFARDIKTSQQIAESFPR------------VVNAYTTELEVKNDDVDEHNLNLSVACQHVDGSMNALERNSRLTWLKLTNAR-SEGVDVPALDSVIFFNPRNSMVD----VVQSVGRVMR.................................................................................... 599
34 -11.200[J] KOG0327 Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases  ali follow..  13  56..............................................................................................................................................................................................................SAIQQRAILPCIKGYDVIQAQSGTGKTTFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYM--------GASCHACIGGTNVRAEVQKL-------------QMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADELSRGFKDQIYDIFQKLNSNTQVVLL--------------------------------------------------SATMPSDVLEVTKKF-------------------------------------MRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLY-----ETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNREN-----YI-IGRGRKGVAINMVTEEDKRTLRDIETFYNT............................................................ 393
35 -11.100[L] COG3893 Inactivated superfamily I helicase  ali follow..  10  1M--TLTHHAKRVLTIAAGTPFLKTLAETLCDGRLTAGYRYDPTD-----------ASVTIYVPTR-IRPLGETDDDSGFFDIENPEIMDLAPPISGTGRQIELARLILAWRNSLP---DAIRAIHSDSPLVAPASPADAIWLARALGEVIDAMDTEEKDWEALQHLDTGEHAQLTADFLKIASVFWPARLAELNRSSAGRHRNAILRAEADRLANLPDTGPIIVAGSTGSIPAAADLIAA---VAALPQGTVVLPGLDLAMPEEQWQAIIEDPTDPSSRTHPQYGLYMLLQKLGMSRDEVVQIGALDRDLEKRAAVFSAALAPAKSTSDWNGWREGRDPGFFDEAFAAATLIEAANQREEATAIAVALRLPGRPSQAALITPDRGATELQRFGIEADDSAGTPLSATPQAGLTQLALEAILRPGDPVPIISLLKHPDAFTKASKALELIALRGGRVETEIGNLEVVLDAQLLAQRDNRHPPAWRVALPEGSVDAARDRRDRSGRAFTDKLPLSDWAGRTGRVIEAICADDSNDLAALWSGEAGDKLSSLFAELMESGDILDADFAALVAGESIKPRSMRHPRIFIFGALEARLQSVDTVVIGGLNEGLWPGQTANNPFLSRSMKTA--IGLEPPERRIGQLAHDFEMANGT--------------RQIFYTRALRQGSTPAVASRWLQRLLA................... 729
36 -11.000[A] KOG0330 ATP-dependent RNA helicase  ali follow..  13  70..............................................................................................................................................................................................................TPIQQEAIPVVLNKRDVI-GLAGSGKTAFALPVIQELWNNPSPFFAVVLAPTRELAYQISEQFEAIGGSI--------GVRSVVIVGGMDMVTQAVALSKKPHVLVCTPGRLMDHLEN-------------TKGFSLKNLKYLIMDEADRLDMDFGPIIDKILKIIPHERRTLLF--------------------------------------------------SATMTSKVEKLQRAS--------------------------------------LHQPVRVAVSSKFSTVDTLIQRYLFFPFKHKDTYLVYLV-----NELAGNSIIIFARTVNDTQRLAILLRTLGFSAIPLHGQLSQSNRLGALNKFKSGTLVATDVAARGLDIPLVVVINYDIPTDSKAYIHR---VGRTRARAGKSIALVTQYDLEPFLRIEATIGKKMQ-EYEIDKEGVFLLSERVGEAQREAIIQMKEI.......................... 439
37 -10.900[J] KOG0328 Predicted ATP-dependent RNA helicase FAL1, involved in rRNA maturation, DEAD-box superfamily  ali follow..  11  50..............................................................................................................................................................................................................SAIQQRSITPIVKGRDVIQAQSGTGKTAFSISILQSLDTTLRETQVLCLSPTRELAVQIQKVILALGDMM--------NVQCHVCIGGTNLGEDIRKLDYGQHIVSGT----------------RVFDMIKRRVLRTRAIKMLVLDEADELNKGFKEQIYDVYRYLPPATQVVLI--------------------------------------------------SATLPHEILEMTSKF-------------------------------------MTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLY-----DTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSDMPQKERDEIMKEFRAGQSRVLITTDVWARGIDVQQVSLVINYDLPNNREL-----YI-IGRSRKGVAINFVKSDDIRILRDIEQYYST............................................................ 386
38 -10.800[R] COG1202 Superfamily II helicase, archaea-specific  ali follow..  10  211.......................................................................................................................................................................................................LEGITELLPVQVLAIKNLKGENLLVVSATASGKTLIGELAGIPKALE--GKKMLFLVPLVALANQKYEDFKRRYSKL--------GLKVAIRVG------------SRIKTREEPVVVDTGIDADIIVGTYEGVDYLLRSGKKIGNVGTVVIDEIH------------MIDDEERGPRLDGLIARLRKLYPK---------------------------------QFIGLSATVGNPQELARSLGM-----------------------VLYDERPVDLERHLIIARNES---------------------EKWRIIAKLCKAEVMRKSSKGFKGQTIVFTYSRKRCHELASFLTGKGLKAKPYHSGLPYKQREMEFQAQMIDVVVTTAALGAGVDFPASQVIFESLAMGNKWLSVREFHQMLGRA-KVYLIVEPGKKYSAQMDETEDEVALKLLTSPIEPVIVEWSSVIEEVNSLTLGANRSAKKVLEKLEELGMVSIR............ 634
39 -10.800[D] KOG0987 DNA helicase PIF1/RRM3  ali follow..  362...........VPRTIEDAYYLRILLNIKRGVTSYKDLKTVKGVVH---------KSFRDAVFALGLLDDDKEYINGIKDAKFWCSAKYVRRLFVIMLLSESLTKPEMVWDETWRILSEDIERRKRKEWKRPDLQLSDEERQQYCLQEIARLLTK---NGVSLSKWKQMPQISDEHVEKCNHFILDERKYDRAYLIEKHEEWLTMVTSEQKKIVLHDRGGVFFVYGFGGTGKTFLWKLLSAAIRSKG---DISLNVASSGIAALLRTTHSRFGIPINPNESSTCNI-----------------------------------------------SRGSDLGELVKEANLIIWDETPMMSKHCFESLDRTLRDIMNNPGIVFGGDFRQVLPVINGAGREEIVFAALNSSYIWEH------------KVLELTKNMREKRDIEYFSKSIIEAVYGNTFMEEKDPKFFQGRAILCPTNEDVNSINEHMMSMLDGEERIYLSSDS----IDPADTSSANNDAYSADFLNSVRVSGLPNHCLVMLLRNMDPNKGLTRLQVTQMADTVIQARFITGNRVGKIVLRRQFPLSVATINKSQGQTLESVGLYLPRPV------SHGQLYVAISRVTSKTKFF............................................................................... 996
40 -10.700[L] KOG0991 Replication factor C, subunit RFC2  ali follow..  13  53.................................................................................................................................................................................................................NEDTVSRLEVPNIIIAGPPGTGKTTSILCLARALLGPALKDAMLELSNDRGI-DVVRNKIKMFAQ--------------------------------------------------------------QKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSR------------AVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFG-------------------FINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDII.............................................................................................................................................................................. 296
41 -10.700[R] COG1201 Lhr-like helicases  ali follow..  10  20.......................................................................................................................................................................................................TLGFTRPTEPQERAFPHILDGHTLLIAPTGSGKTEVFNAILKKKPEKRSGISALYITPLRALNRDMLSRIEVMGKLL--------DIKVQVRHG---------------DTPQSERQRQSRNPPDLLITTPETLQAMFSGSRLRKNMTHVVVDEIHE------------LASSKRGAQLAIGLERLVEISGE---------------------------------QRIGLSATVGNPWEIAKFLAG-------------------ANRDFTVIEVALLKLLEFDVISPQVSGEAE-----DREVMEIARTVGCEPEFASHLSLIRKIVEES---QSTLIFVNTRQSAEALAAGFRKLGASIGVHHGSLSFEARVEEEAFKAGALRICTSSMELGIDIGNVDRV----VQYGSPRQVSRLLQRVGRAGHRLHEVSRGTVLSMEADDTAESMALEGRVEDISPHVNSLDVVANQIAGMVMDFGEGIEKIFRILRRADLRPEELQRVVD...... 449
42 -10.600[LKJ] COG0513 Superfamily II DNA and RNA helicases  ali follow..  11  26..............................................................................................................................................................................................................TPIQAGAIPPALERKDVL-GIAGTGKTLPMLTLLEKGRARARMPRTLILEPTRELAAQVEENFVKYGINH--------RLNVALLIGGVSFEEQERKLERGADVLIAT----------------RMLDHFERGKLLLTGVEILVIDEADRLDMGFIPDIERICKLIPFTRQTLFF--------------------------------------------------SATMPPEITKLTEQFLHS------------------------------VRIEVAKASSTAKTVTQR-------LVKSGKKDWDKRAVLRDLIQ---SEGDSLKNAIIFCNRKKDVSELFRSLTRHEFDAGADMDQRARMAMLSSFKDGKLRLLVASDVAARGLDIPDVHVFNFDVPIHAEDYVHR---IGRTRARSGKAFTIVTSSDTKYLAAIESMIGE............................................................ 368
43 -10.600[A] KOG0332 ATP-dependent RNA helicase  ali follow..  236................................................................................................................................................................................................................QETALPLLLMEPPSNLIAQAGTGKTAFVLTMLCRIDVNLMCPQCICLAPTLELAKQIGEVVEKMGKFIDNLKI----------------------HYAIKGGNMAAMRGRKLTEQIVIGTPGITRDYLQKYKCIDSKIRCLVLDEADVGFTDISTTIYNMVEDASDSVQSMLF--------------------------------------------------SATYDEPVINFATKIIKN------------------------------IVVMLKREEQALPNIKQ--------FYVQCACRDSKYAAIVNLY-----SGLAVASSVIFCHTKASVMWLYENMRARGHQVDVDMTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQVVVINYDLPIKYTDEGTPMVYL-IGRTTGIAINLIDSEDSMNMINVLENHFQMKIA-RMDPSNLVELEAIE.......................................... 611
44 -10.600[L] KOG0990 Replication factor C, subunit RFC5  ali follow..  12  56.................................................................................................................................................................................................................HRDIIDTIDRPHLLLYGPPGTGKTSTILAVARKLYGPKYRNMILLNASDDRGIDVVRQQIQDF-------------------------------------------------------------ASTQSFSLGKSSVKLVLLDEADAMTKDAQFALRRVIEKYTKSTRFALIGNHVNKIIPALQSRCTRFRFAPLDGVHMSQRLKHVIEAERLVVSDCGLAADMRKALNILQSTHMASKEITEEESKQITEEDVYLCTGNPLPKDIEQISHWLL-----------------------------NKPFDECYKDVSEIKRKGLAIVDIV.............................................................................................................................................................................. 309
45 -10.500[F] COG1435 Thymidine kinase  ali follow..  10  5.............................................................................................................................................................................................................................YFKYGTMNSGKSIEILKVAHNY--EEQGKPVLL----------MTSSLDTRAGVGTVASRIGMKAEAV--------------------------------------AIDEEMSVFDYVNSLPAKPFCVLIDEAQFLNKKHVYDFARVVDELEGSKYLLLLADKIEEIKT................................................................................................................................................................................................................................................................................................................................. 141
46 -10.400[L] COG1198 Primosomal protein N` (replication factor Y) - superfamily II helicase  ali follow..  11  256.......................................................................................................................................................................................................ASRPLELNPEQRQARDAVVSPPFLLQGITGSGKTEVYLQIIQGALDK--GKTAILLVPEISLTPQMTERFIARFGD---------KVAILHS-------------------GLSNGEKYDEWRKVERGDAQVVVGARSAIFAPLKNLGVMIIDEEHEYKQD-YHAREVAILRAQYNQATLVLGSATPSL---------------------------ESRARAGKGVYQHLRLTQRANPQVIDFRDYIGQN----------ETSNFTPPLLEAIQDRLVKKEQVVLMLNRRGYSSFVMCRECGTVDTCPNCDTLHMDTKTMTQKAYDELAELFPQARILRMDVDTTRKKGSHQALLDQFGRGEAD-------------------ILLGTQMIAKGLDFPNVTLVGVLNADTALN------FRSSERTFQLLTVAGRSGRAEKAGQVLIQSYNPQHYAIRFAKDQDYEGFYAYEMGIRRQLGYPPYYFTIKKEEEVFKRAYEVMNILRSGLSET 735
47 -10.200[NU] COG2874 Predicted ATPases involved in biogenesis of archaeal flagella  ali follow..  12  39..............................................................................................................................................................................................................................LIEGENDTGKSVLCQQFVYGGLMS--GHNIAYYTTENTIKSFLRQ---------------------MESLSLDVSDFYAWGYLRVFPVHLEGIDWSTEQMRSILNLVANHIKTIRE--------NIAIIDSLTMFEDDVLEFLTRLKNLCDNGKTILITLHQHA..................................................................................................................................................................................................................................................................................................................................... 176
48 -10.100[L] COG0470 ATPase involved in DNA replication  ali follow..  30.................................................................................................................................................................................................................QNEVITTVRKPHLLFYGPPGTGKTSTIVALAREIYGKNYSNMVLELSDDRGI-DVVRNQIKDF---------------------------------------------------------------ASTRQIFSKGFKLIILDEADAMTNAAQNALRRVIERYTKNTRFCVLANYAHKL................................................................................................................................................................................................................................................................................................................................... 153
49 -10.100[A] KOG0344 ATP-dependent RNA helicase  ali follow..  12  81..............................................................................................................................................................................................................TPIQMQAIPVMLHGRELL-ASAGSGKTLAFSIPILMQLKQPANKRALIISPTRELASQIHRELIKISEG--------TGFRIHMIHKAAVAAKKF-------------------------------------GPKSSKKFDILVTTPNR---------LIYLLKQDPPGIDLWLVVDESDKLFEDGKTGFRD------------QLASIFLACTSHKVRRAMFSATF--AYDVEQWCKLN-------------------------------------LDNVISVSIGARNSAVETVEQELLFVGSETGKLLAMRELVKKGFN-----PPVLVFVQSIERAKELFHELIYEGINVDVERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVLVINYDFPTSSVEYIHR---IGRTRANKGKAITFFTEDDKPLLRSVANVIQQAGC......................................................... 428
50 -10.000[R] COG4928 Predicted P-loop ATPase  ali follow..  34...............................................................................................................................................................................................YAPFAKNLAESICKMSPPDGLVI---------VYAPWGLGKSTLLNFIIHYLKQKPEQEQPIIVPYNPWWFSGQEDLTKSFFEQLSGV---LYEKWQSLGRKFKNQIESFAERVSTVPGLWTKGFAATVKTVISPKDIHKLKQEIEETLKKQQKRILVVIDDIDRLTAEEIRQLFRVIKAVANFPNVLLLFDKIKALEEIQKINGEVYL-------------------------EKIVQVSFELPLQLSRLFDSQLDKIISGTPEELFDQKYWLEIYWQGIEHFITT-----------------------------------RSILRLANTLMPGVKGEVNFVDFVAIETIRLFYPTVYNIIRNNPELFTFGVRFLTVPRIIDEEKIKEFHNTWINQINERDRNAVKFILTKIDNYFQNKRRYLHIVYFRLAIPEGNI------------ISEMQAILALANN---CQAFGAKLVELSAQMRPDGISRINVFLDRLRDYVDKDIPLNDVEPILQ...... 494
51 -10.000[A] KOG0922 DEAH-box RNA helicase  ali follow..  11  40.............................................................................................................................................................................................................IASVEKRLVEEVQKNDILI-GETGSGKTTQLPQFLYNAGFCREGKMIGITQPRRIAAVTVAKRVAEECEVQLGQKVGYS-----------------------------RFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHD-TDVLLALLKKIQRTRSQPVSEKTEFGNVASQVQTTTR---------------------DANGPQQNGVLKGYQGRKLSPLKLIIMSASLDARVFSEYFGGAKAVH-------------------------------------QGRQFPVDILYTVHPESDYVDATLVTIFQEK--PGDILVFLTGQDEIESVERLVQERLQNIPEDKRKLQQMKVFAPAPTGFRKVILATNIAETSITIPGIYVIDPGFVKARSYDPSSLDVVPASKAQTLQRSGRAGREGPGKSFRLYPEREFEKLEDSTKPEIKRCNLSNIILQLKALGIDDIVGFDFIDKPSRGAIIKALAELHSLGALAD 479
52 -9.990[A] KOG0345 ATP-dependent RNA helicase  ali follow..  11  38............................................................................................................................................................................................................FCTPVQAATIPLLCSYKDVADAATGSGKTLAILRRSTSFPPKPHQVMGVIISPTRELSTQIYNVAQPFVSTLANVNSVL--------------------LVGGREVKADMKIIEEEGCNVLIGTPGRLSDIMERMEILDRNLEILILDEADRLEMGFQRQVNYIISRLPKQRRTGLFATQTEGVEE-------------------------------------LAKAGLRNPVRV-----------------------------------------EVRAKSKSESSQQLTNSKTPSGLHLEYMECEADKKSSQLVDLLIK------SDKKLIVFFMTCASVDYWGLVLSKIPALKSISLIPIHGDMKQASFTKASSGALLCTDVAARGLDIPGIYVVQYDPPQDPNMFNHR---AGRTRLRQGRAIVFLLPKEEAYVEFMRIRRVPLEERKCSEDASDVIPIIRSAAMKDRAVMEKGLKAFVSFVRA................... 440
53 -9.960[R] COG1204 Superfamily II helicase  ali follow..  10 1364............................................................................................................................................................................................................FFNKIQTQVFNSVTNDSVFIGAPNGSGKTVCAELALLHHWSQEDYGTAVYIAPIQEIVDRDGKVLVKLTGERSQDLKLIQVADLIFCTPSQ-----------------------------------DSLSKRWRSMRSIQKVDFYICDELQLLGGFYGPLYEIVI------SRIRYMAVQLEK----------RVVGLSVS-----NARDLGEWLGTSPQCIFNFSPKDR-PNPLTIHLQSF------SITHFPSLMLAMSKPIYRSLKNFISQRKSTIVFKVAKQLAFDLVTFSMADEDEYLFSLMENEAFNKVEDALQQSLKHGIAYISEITSSNDQNIVQYLYRH-----------------------------KVLIASRDVIYSLKAKSVIVMGTQYYDGKEHRYIDYLLQMLGFTLSQVILMTVTTKKEYYKKFLNEPLPMESHLQVWLHDAFVSEISTQTIESKQDAVD............................... 1788
54 -9.780[L] KOG2859 DNA repair protein, member of the recA/RAD51 family  ali follow..  13  48...............................................................................................................................................................................................................................ITGASTSAKTQILIQAAISCILPKTGKLVLFL-FDLRLSQMLKHRLLQANWLGNGAWWQLEESNVKSCKSAEEKTKTVFDEELYASCMKRFLYVRCYDSLELLSSLKTLHYRIQQQEACGSQVGVLMIDSIGAFLTNVVETIVQELKKLLLVHSLVVLA-TKGTIYEEKYP............................................................................................................................................................................................................................................................................................................................. 252
55 -9.660[A] KOG0331 ATP-dependent RNA helicase  ali follow..  13  118..............................................................................................................................................................................................................TAIQAQGWPVALSGLDMV-GVAGSGKTLYLLPAIVHINHQPFLERCLVLAPTRELAQQVQQVAAEYCRAC--------RLKSTCIYGGAPKGPQIRDLERGVEICIAT----------------RLIDFLECGKTNLRRTTYLVLDEADRMLDMGFE-IRKIVDQIRPDRQTLMW--------------------------------------------------SATWPKEVRQLAEDF-------------------------------------LKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSE--KENKTIVFVETKRRCDELTRKMRRDGWPAMGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVFVINYDYPNSSEDYIHR---IGRTRSKTGTAYTFFTPNNIKQVSDLISVLREANQ......................................................... 465
56 -9.630[R] COG1444 Predicted P-loop ATPase fused to an acetyltransferase  ali follow..  219.............................................................................................................................................................................................................ATQDQVEVLKLFKKQALVIIADRGRGKSAALGLGLAGIGHKKARVQIVVSAMEYSNLETLLEFALKGLEALGYKPGVEREGGEIRAIKASGIFIDVVT----------------------------------YMLLKRENADIVAIDEAAGVP---LPVLYAVHKK----NRLVFA---------------TTIHGYEGAGRGSIRFLKYLKEARDTDVYLYEMEEPIRRGDPVEEWLFDAFLLNAEPAKIEAEDLEYVKRQEVLYLKEEDILKSEEVFRQ---------------GIYVQAHYRNEPDDLGMLLDTARALALPNGKIVVSVELAYEGGLDDLSIDQALRGLKLPGNIIPDRFLKYWRLPEFAKLRGWRIVRI-QDMGLGTLMLKKIGMDYVGVGFGVYDRLLYVPISGEYSVLLVKPLNEKAEAYVKYANIEFRRR........................................................... 645
57 -9.580[T] COG0467 RecA-superfamily ATPases implicated in signal transduction  ali follow..  1.............................................................................................................................................................................................................MIDQETDGIEKLETG-TLIAGTAGSAKTIFASQFLVEGIQR--GENGVFVTFEEP-PKALRKNMRGF--------------------GWDIQQWENEGKWVFVDASPQPGDRPIVSGEYDLGALIARIEHAVRKYKA----SRISLDSLGAISAQVRSDLFRLASALRELGVTAIMTAERVEEYGEI----------------------------------------------------------------------------------------------------------------------SRYGVEEFVADNVVIVRNVLADEKRRRTIEILKYRGTDHQKGEFPFTIINKKGIVIIPLSAIELEQKSSDIRITSEELDRM-GFFRDSIILVSGATGTGKTLMVTEFMDGGVANGERCLVFA--------FEESREQLIRNATGWGVDFKQMEKEGKLKYPETTNLENHLIMMKDIIQEFKPNRVAVDSLSALERVSTLKS 383
58 -9.570[A] KOG0347 RNA helicase  ali follow..  11  215..............................................................................................................................................................................................................TKIQKACFNVAAYQGKDVIGAAGSGKTLAILQRLLDEREKVGKLRALIITPTRELALQVTEHLENAAKNL--------SVKVVPIVGGMFSEKQERRLKEKPEIVVATPGR-----------LWELMSAGEKHLVELHSLSFFVLDEA-D----------RMVERG--------HFRELQSILDL-------------------VTDKPNEGKTQTVKSNDTVLNVPKKKRQTFVFSATIALSS-DFRKKLKRGSSKSKQSSSGEVNSIEVLSERAGMRDNVAIIDLTTTSILAPKIEESFIKCEEKEKDAYLYYILSV-----HGQGRTIVFCTSVTDLRHISGLLKILGLDVCTEMKQRARLKSIDRFRASENGILIATDLVARGIDIKNVTIIHYKLPHSAEV------YVGRTRAADGCSIALIEPNETSKFYTLCKSFSME-SVKIFPLDNSYMPAVRKRLYLARQIYEIERKG--SRENADRTWLKKHAESMELELDDE 681
59 -9.550[S] COG3410 Uncharacterized conserved protein  ali follow..  11  11.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DDCGAMYEAIKEKDRQY---GQCRMLSTYDFPYRLDGKDYYVECGDNFKVRWDRYTPREVTPWSERCDTIEVGSVYTIQGFDLNYAGVILGRSIGYDAAN-MNSINVLLTRGVRGLYVYAYDPELRERLLRPSK................................................................ 174
60 -9.530[D] COG1192 ATPases involved in chromosome partitioning  ali follow..  11  11................................................................................................................................................................................................................................KG--GVGKTTLTVNLATCLAKYF-QKRVLVLDLDKTLSYLLANAIQDIFDIICPEICQIEGLELIPGDIELYDEYLVSEKLHQAAIATENPNFETVWNKFEGTLIKEMLAPVLEE------YDFVILDVGMQLLERRIEKLKESHKASDDPLNINLIGGLMSRYYNQVMRRVQTDFTPGQLFQQSIPMDVNVAKAVDSFMPVVTSMPNTAGSKAFIKLTQEFLQKV..................................................................................................................................................................................................................................................................... 294
61 -9.530[F] COG1618 Predicted nucleotide kinase  ali follow..  13  1...........................................................................................................................................................................................................MRIEGKEKTMLR------IAVTGSPGVGKSTVVAKTAEKLAEKP----------GFKIGGIRTAEIRK---------------------EGHREGFSIRDLATGKTGILSHVKGSGPRLGKYHVNLDDLERIGANAVRNALACDLVVIDE-ELISQSFVSAVEEVLESDKP---LAVLHHSSRHPLAQRFRKGFEVLTVDKGNRDEL............................................................................................................................................................................................................................................................................................................. 171
62 -9.420[L] COG3598 RecA-family ATPase  ali follow..  356...............................................................................................................................................................................................................ELAPELIKGVQGHKMLIAGPSKAGKSFALIELSIALAEGQKQGKVLYVNLELD-RPSALHRFKDVYDAMGLPPANVANIDIWNL---------------------------RGKTVPMDKLAPKLIRRSLKKN-----YQAVIIDP-ENSADQMAHFTNQFDKVATELGCSVIYCHHHSKGSQGGKKSMDRASGSGV----ARDPDALIDLVELELTEDLIKARSEKAAAKIYQQALQEKALGYYQQEVTLDDLESRYQMQQHFDKAIKDIMVKQPYLEAVKKAQHEVEIATAWRVDGTLREFAKFQPVNMWFSY-TGVLADIQLEDSKPLWKKAKEARKSKEENLKERNQKLETAYSALFDGSTPVTVQEIREYLDLKSIKEHDGYDVKKGVVFQISDNKETEKKENN............................................................................................... 757
63 -9.360[L] COG0556 Helicase subunit of the DNA excision repair complex  ali follow..  10  1...............................................................................................................................................................................................MSKAFELVSDYQPAGDQPTKQLLEGLEAGHQTLLGVTGSGKTFTLAN-----VIATAQLPTIILAPNKTLAAQLYGEMKAFFPNNANAHIEQMRLSATKALLERKDAVIVASVSAIYGLGDPDSYLKMMLHLRRGDVIRDMLRRLAELQ-----YSRNMAFERGQFR------VIDIFPAESDQERVEMFDDEIECISLFDPLTGVITTPRERILEAIEQIKSELQVRRQYLLDNNKLLEEQRISQRTQFDIEMMNELIIDESHVTVPQIGAMFKGDRSRKETLVEFGFRLPSLTKSGGEVAEQVVRPTGLLDPIIEVRPVATQVDDLLSEARIRAANDER---ILVTTLTKRMAEDLTEYLHEHGVKVRYLHSDIDTVERVEDLRLGVFDVLVGINLLREGLEVALVAILDADKEGFLRSERSLI-TERRREEQRGITPQPLKRSVKDIMELGDIAKSRKQKNSKVVPLAKVAEESAAYQVLTPQQLEKEISKLEAAMYQHAQNLEDEIHQLRQQFIA. 674
64 -9.350[U] COG3451 Type IV secretory pathway, VirB4 components  ali follow..  168..................................................................................................................................................................................................LAPTYRNQLAFIDIFFRG--MNNTNYNMAVCGTSGAGKTGLIQPLIRSVLDS--GGFAVVFRFNAERIRDQLSVMASPNGNLDEVHEGLLLQAVRAAWLTKKNRARIDDVVDFLENARTSEQYAESPGIRSRDEMIVLLNQYTAAGTYGRYFNSMVVLELGGLEDR-IIYIENRMYRTPRNLKKLNVIDEGWRLLDFKNRKVGDF-----------------------------IEKGYRTARR-------------------------------------------------------------------------HTGAYITITQNIVDFDSDKASSAARAAW---GNSSYKIILKQSAKEFAKYNQLYPDQFPQLHRE--------MIEKFGAAKDQWFSSFLLQENHSSWHRLFVDPLSRAMYSSDGPDFEFVQQKRKEGLSIHEAVWQLAWKKSGPEMASLEAWLQEHETFRGTYEYKAETD.............................. 593
65 -9.340[A] KOG0342 ATP-dependent RNA helicase pitchoune  ali follow..  11  111............................................................................................................................................................................................................TMTEIQKRSIPPLLAGR--VLGAAGSGKTLAFLIPTIEMLYALKGTGVIIISPTRELALQIFGVAKELLKYH--------HQTFGIVIGGANRRAEADKLVKGVNLLVAT----------------RLLDHLQNTKGFVRNLRSLVIDEADGFEDEMRQIMKIL--PSENRQTLLFSATQTTKVED-------------------------------------LARISLKPGPLYVNVDSG--------------------------------------------------PTSTVEGLEQGYVVVDSDKRFLLLFSFLKRNLKK-----KVIVFMSSCASVKYMAELLNYIDLPVL-KQKQQRRTNTFFEFCNAEKGILLCTNVAARGLDIPAVWIVQYDPPDDPRDYIHRVGRTARGTKGTGKSLMFLAPSELGFLRYLKTAKVSLNEFEFPANKVANVQSQLEKLVSKNYYLQQSAKDGYRSYLQA.................. 500
66 -9.310[KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family  ali follow..  514...............KSEKKIVEFMTETIPANQ-HRITFNCPENLSGQFIYDETIFELFREGSDINYYEADLKVHGLLKGVPLDLLWDCISAKKRFLE---GQQSKGTRRGKVNSGKLPCILVLDLEKIAPVVQIFNEIGFKVLDDLVSLDQFEALPVNFSMSERLIEIQKQIRGEIEFDFQDVPQQIQATLRSYQTEGVHWLERLRKMH-------------LNGIMGLGKTLQAIIAVTQSKLEKGSGCSLIVC--TSLVYNWKEEFRKF----------NPEFRTLVIDGVPSQRRKQLTALADRDVAITSYNLLQKDVELYKSF----------------RFDYVVLDEAHHIKNRTTRNA-KSVKMIQSDHRLILTGTPIENLWSLFDFLMPGLLSSYDRFVGKYIRTGNYMGNKADNMSPFILR---RMKEDVLK-LTESQKELYQSYAASAKQELSRLVKQEGFERIHIHVLATLTRLKQICCHPAIFAKD--------APEPGDSAKYDMLMDLLSSLVDSG---HKTVVFSQYTKMLGIIKKDLESRGIPFVYLDGSTKNRLDLVNQFNEDPSLLVFLI-SLKGLGADTVIHYD-NPAVENQATDRV---IGQSRSVSSYKLVTLNT-------------------------------IEEKILTLQNRKKSLVKKVINDEVVSKLTWEEVLELLQI..... 1166
67 -9.290[D] COG3640 CO dehydrogenase maturation factor  ali follow..  12  1.....................................................................................................................................................................................................................MEGFGMPKLIISGRGGSGKSTLVTLIAHTLKEQ--KKRVLVV--NIGLSGIL-GGKPRVMKKLRSMIRDGETEPELFREKFDLESLSQEFVCWVGSLGLMQIGKIDHAMEGCACPMGAVTRDFLNH--RLEEDQWVLVDTEAGVEHFGRGIVEGA------DAVVMVVDPSSDAV................................................................................................................................................................................................................................................................................................................................... 181
68 -9.240[P] KOG2825 Putative arsenite-translocating ATPase  ali follow..  6.............................................................................................................................................................................................................LPGTLENLLEQTSLKWIFVGGKGGVGKTTTSCSLAIQMSKV--RSSVLLISTD---AHNLSDAFGTKFGKDARKVPGFDNLSAMEIDPNLSIQEMTEQADQQNPNNPLSGMMQDLAFTIPGIDEALAFAEILKQIK-SMEFDCVIFDNFPTVLEKALGKLGGLSSRFGPMINQMGSIMGVNANEQDLFGKMESMRANISEVNKQFKNPDLTTFVCVCISEFLSLYETERMIQELTSYEIDT......................................................................................................................................................................................................................................................................... 252
69 -9.210[P] COG1348 Nitrogenase subunit NifH (ATPase)  ali follow..  11  5..............................................................................................................................................................................................................................AIYGKGGIGKSTTTQNLTSGLAEL--GKKIMVV--TRLLLGGLAQKTVLDTLREEGEDVDLDTI-----------------KTGFGNIKCVESGGPEPGVGCAGRGIITSINMLEQLGAYEDELDYVFYDVLGDVVCGGFAMPIRYIVASGEMMAMYAANNISKGISKFANTGGVRLGGIICNSRKVKNEKELLEAFAKELGRSHEVQKAEINKQTVIQFN............................................................................................................................................................................................................................................................................ 228
70 -9.170[A] KOG0341 DEAD-box protein abstrakt  ali follow..  11  170..............................................................................................................................................................................................................TPIQVQGLPVILAGRDMI-GIAGSGKTLALQEEMMMPIAAGEGPIGLIVCPSRELARQTYEVVEQFVAPLVEAG--YPPLRSLLCIGGIDMRSQLEVVKRGVHIVVAT----------------RLKDMLAKKKMSLDACRYLTLDEADRLVDLGFE-IREVFDHFKSQRQTLLF--------------------------------------------------SATMPTKIQIFARSALVKPVTVNVGRAGAANL--------------------------------------DVIQEVEYVKQEAKIVYLLECLQK------TSPPVLIFCENKADVDDIHEYLLLKGVEAVAGKDQEDREYAISSFKAGKKDVLVATDVASKGLDFPDIHVINYDMPAEIENYVHRIGRTGRCGKTGIATTFINKNQSETTLLDLKHLLQEAKQ......................................................... 522
71 -9.150[D] COG2894 Septum formation inhibitor-activating ATPase  ali follow..  18  6.............................................................................................................................................................................................................................VVTSGKGGVGKTTSSAAIATGLAQK--GKKTVVIDFDIGLRN-----LDLIMGCERRVVYDFVNV----IQGDATLNQALIKDKRTENLYILPASQTRDKDALTREGVAKVLDDLKAMD-----FEFIVCDSPAGIETGALMALYFA------DEAIITTNPEVSSVRD................................................................................................................................................................................................................................................................................................................................. 152
72 -9.060[O] KOG0733 Nuclear AAA ATPase (VCP subfamily)  ali follow..  6..........TSLSRDLERKIHERLVSLKDTIQQTEIEEW--PVSTRRAIQFVQERDMSLRRIKK-VLDTLKAE-KLASSQDLVLVDSDMEEQSDSNLMEVKDTNVINKSITSLWSSPNLKEIDGEDEKKSVGQESITGSAKRKDRRSKTNGSKRQKAEANREPPSDISLSDIGGLDDCINELLELVAMPIK--------------HPEVYQYTGIHPPRGVLLHGPPGCGKTMLANALANELGVPFISIS-IVSGMSGESEKKVREVFEE-AKSLAPCLMFIDEIDAVTPKRESAQREMERRIVAQFLTCMDELSFEKTDGKPVLVIGATNRPDSLDSALRRARFDREICLTVPSQDAR-EKILRTMAKGLKLSGDF-----DFRQLAKQTPGYVGADLKALTAAAGIIAIKRIFNEISPLNKLDLNSDPRFNELDSDMALDSNDSLPLDHSSIIQRYLNAHPDPLSPEELEPLAICPQDFIEALAKVQPSSKREGFATVPGVSWNNIGALKSIRVELQMAIVQPIKR--APTGVLLWGPPGCGKTLLAKAVAN---ESKANFISIRGPELLNKYVGESERAVRQVFLRARASSPCVIFFDELDAMDSLSEASSRVVNTLLTSDRSGVYVIAATNRPDIIDPAMLRPGRLDKTLLVDLPDAHEVEILKTLTKQTPLHEEVNLDVLGRDERCSNFSGADLAALVRE..... 707
73 -9.030[O] KOG0741 AAA+-type ATPase  ali follow..  223.............................................................................................................................................................................................................LDKEFSDIFRRAFAFRVLLYGPPGCGKTLL----ARQIGKMLNAREPKVVNGPEILNKYVEANIRKLFAD---------------------------------------------------------AEEEQRRLGANSGLHIIIFDEIDAICKQ--TVVNQLLSKEQLNNILVIGMTNRPDLIDEALLRPGRL-------------VKMEIGLPDEKGRLQILHIHTARMRDIKELAVGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQ--PLVSVLLEGPPHSGKTALAAKIAE---ESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDLDYVPIGPRFSNLVLQALLVLLKRKLLIIGTTSRKDVLQEME---MLNAFSTTIHVPNIATGEQLLEALELLGNLKDKERTTIAQQVK.................... 699
74 -9.010[J] KOG3928 Mitochondrial ribosome small subunit component, mediator of apoptosis DAP3  ali follow..  10  101......................................................................................................................................................................................................VRKPALELLHYLKNTSFAYPAIRYLLYGEKGTGKTLSLCHVIHFCAKQ--DWLILHIPDAHLWVKNCRDLLQSSYNKQRFDQPLEASTWLKNFKTTNERFLNQIKVQEKYVWNKRESTEKGTRVRNATDAVGIVLKELKRQSSLGMFHLLVAVDGINALWGALVHNLRKMMKNDWHGGAIVSALSQTGSLFKPR............................................................................................................................................................................................................................................................................................................................... 320
75 -9.010[LK] COG1200 RecG-like helicase  ali follow..  10  268............................................................................................................................................................................................................QPTNAQKRVVSDIEQDMRLVQGDVGSGKTLVAALAALTAIDN--GKQVALMAPTEILAEQHANNFRRWFKPFGIEVGWLAG-----------------------KVKGKSRQAELEKIKTGAVQMVVGTHALFQEEVEFSDLALVIIDEQHRFGVHQ-HQLIMTATPIPRTLAMTVYADLDTSIIDELPPGRTPITTVVVSEERRAEIVMRVKNACVNEKRQAYW--------TLIDESEVLEAQAAEAIWEDL--TKALPMLNIGLVHGRMKPQEKQDVMMR------------------------KNAELDLLVAT--TVIEVGVDVPNASLMIIEN------------------------------------AERLGLSQLHQLRG-TASFCVLMYKPPLGKVSQKRLQVL--GFVISEKDLEIRGPGEVLGTKQTRVANLMRDRKMIPTVQHYAKSLIQKYPDVAESLIRR................................ 682

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L, Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H, Xu F, Salvesen G, Godzik A.; RIKEN GER Group; GSL Members. Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res. 2003 Jun;13(6B):1376-88.