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Query: [R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSTMKVAVYGAGNQKLYVDQLNLPEKYGGEAPYGGSRMAIEFAEAGHDVVLAEPARDMLDDAHWKVVEDAGVTVTDNDAEAASEAEIAVLFTPFGKKTFEIAKNITNHLPEGAVIANTCTVSPVVLYYVLERELRRDRKDLGIASMHPAAVPGTPQHGHYVIGGHSSSELDIATDEQISRCVELAESCGKVAYVVPADVSSAVADMGSLVTAVTLSGVLDYYYVGTQIIRAPKEMVEKQILMTLQTIASLVETSGVNGMLKAMNPELLVRSAKSMHLLEEQEELDAALNTLSDLDDEVNKWIEKGEIRHTDLVAAQALAKEIKNLMGGKAAEGTIRRCMRKMFELast
1 -87.200[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali  100  1MSTMKVAVYGAGNQKLYVDQLNLPEKYGGEAPYGGSRMAIEFAEAGHDVVLAEPARDMLDDAHWKVVEDAGVTVTDNDAEAASEAEIAVLFTPFGKKTFEIAKNITNHLPEGAVIANTCTVSPVVLYYVLERELRRDRKDLGIASMHPAAVPGTPQHGHYVIGGHSSSELDIATDEQISRCVELAESCGKVAYVVPADVSSAVADMGSLVTAVTLSGVLDYYYVGTQIIRAPKEMVEKQILMTLQTIASLVETSGVNGMLKAMNPELLVRSAKSMHLLEEQEELDAALNTLSDLDDEVNKWIEKGEIRHTDLVAAQALAKEIKNLMGGKAAEGTIRRCMRKMFE 344
2 -45.300[E] COG0287 Prephenate dehydrogenase  ali follow..  11  1...............MMGDIMFERIALIGIGLIGSSARDVRELGLARHVVISTRSEDTLKRAEELALGT---DYTVSAAEAVKDADLVIVSVPVG-ASESVAQQIAPYLKPSAIVTDVGSTKASVIAQMAPHM----PENVHFIPGHPLAGTEAGFAGLFRERWCIFTPLPGTDAAALERLKDFWRALGSRVDEMDAEHHDKVLAIVSHLPHIIAYNIVGTASEVIKYSASGFRDFTRLAASDPTMWRDVCLHNKDAILEMLARFSEDLASLQRAIRWGEGDKLFELFSRTRSIRRSIIEAGQD........................................ 295
3 -42.700[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  25  1MIDMKLAILGAGCYRTHAASTMGAELKELAGVDE-VVVADPVFDNQFTVIDDFAYEDVIGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDMQPGIIDKFIDDIKPGAIVTHACTIPTTKFYKIFEGDLVTKPETLNVTSYHPGAVPEMK--------GQVYIAEGYASEEAINTLFELGQKARGNAYRLPAELLGPVCDMCSALTAITYAGILSYRDSVTQVLGAPAGFAQMMAKESLEQITALMEKVGIDKMEEHLDPGALLGTADSMNFGASADILPTVFEILEKRKK................................................ 347
4 -35.200[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  11  51.PPLRIAIIGFGNY--------------------GQFLAETLISQGHILFAHSRS-DHSSAARRLGVSY----FTDLHDLCERHPDVVLLCTSILSIENILKTLPFQRLRRNTLFVDVLSVKEFAKTLLLQYL----PEDFDILCTHPMFGPQSVSRGLRFVYDKVRIGEERLRVSRCESFLEIFVREGCEMVEMSVTDHDKFAAESQFITHTLGRLLGMLTPINTKGYEALLDLAENICGDSFDLYYGLFVYNN-NSLEVLERIDLAFEALRKELFSRLHGVVRKQSFEGEAKKVHVFPNCGENDASLDMMRSEDVVVKYEYNIVGFGNFGQFLGKTMVK... 385
5 -25.000[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  14  3....TIGFIGLGIM--------------------GAPMAGHLLDAGYKVIASDHRSKPLAD-----LVAKGLKTVSGHAAVAKAADIIITMVPDTPQVADVLNGVASGLTRGKLVIDMSSISPIETKVFAGKINE--LGCDYLDAPVSGGEVGAKAASLTIMVGG--------EEKAFERAKPVFEKMGKNITLVGPNGVGQTTKVAQIVVALTIEAVAEALVFASKAGADPARVRQALMGGLAA--SRILEVHGERMVKRTFAPGFRIELH--------QKDLNLALEGAKALGVSLPNTSTTQQLFNSCAANHSALVRALERMAN................. 290
6 -24.500[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  10  1...MQLGMIGLGRM--------------------GANIVRRLAKGGHDCVVYDHDPDAVKAMAGEDRT-TGVASLRELSQRLSAPRVVWVMVPAGNITTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFK---KGIHLLDCGTSGGVWGRERGYCLMIGG--------DGDAFARAEPIFATVAPGLHCGPCGSGHFVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPLPNPECYQYDFDIPEVAEVWRRGSVIGSAIALRESPDLAEFSGRVSDSGEGRWTAIAAIDEGVPAPVLTTAANKALSAMRKQFGGHAEK............ 337
7 -19.800[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  11  1....................MSADFGLIGLAVMG-QNLILNAADHGFTVCAYNRTQSKVDHFLANEAKGKSIIGATSIEDFISKLKRVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKK---KGILFVGSGVSGGEEGARYGPSLMPGG--------SEEAWPHIKNIFQSISAKEWVGPAGAGHYVKMVHNGIEYGDMQLICEAYDIMKRLGGFTDKEISDVFAK...................................................................................................... 220
8 -19.700[G] COG0362 6-phosphogluconate dehydrogenase  ali follow..  11  4..KGDIGVIGLAVM--------------------GQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAKGTNIIGAYSLEDLAAKLEKVMLMVRAGDVVDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAE---KGIRFIGSGVSGGEEGARHGPSIMPGG--------NQEAWQYVKPIFQAISAKTWVGGEGAGHFVKMVHNGIEYGDMQLICEAYQFLKEGLGLSYEEMQAIFAKNTELDSYLIDITTDILGYKDASGEPLVEKILD...................................................................... 257
9 -18.300[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  10  35LKGKKIVIVGCGAQ--------------------GLNQGLNMRDSGLDISYALRPEAIAEKRASFQRATENGFKVGTYEELIPTADLVVNLTP-DKQHSKVVADVMPLMKKDSAFGYSHGFN-------IVEVGEEIRKDITVVMVAPKCPGTEVREEYKRGFGIAVHPENDPKGEGMAIAKAWAAATGGHVLESSFVAEVKSLMGEQTILCGMLQAGSIVCYDKLVADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELMDDIISGHFSATMMADWANGDKDLFAWREATGKTAFENAPKYDGKISEQEYFDNGVL-AMVKAGVELAFD 374
10 -17.400[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  16  3HTKPSIAILGAGRV--------------------GSSLARSAVAAGYEVKVAGSGAVDKIALTAEILMPGA--VPSTADQAVKDADIVFLAVPLHK-----FRSVNPATLEGKIVIDTMNEIDQDPRSTSEIIAEFFAGSTMVKSFNHIGYHEIEQDA----GTGRAIAYATDDVDAGAQVAQLIKSFGFVPLNIGALENGRILEPGQEA...................................................................................................................................... 191
11 -15.700[E] KOG3124 Pyrroline-5-carboxylate reductase  ali follow..  13  1...MSVGFIGAGQLAYALAR----------GFTAAGILS------AHKIIASSPEMNLPTVSALRKM---GVNLTRSNKETVKHSDVLFLAVK-PHIIPFILDEIGADVQARHIVV---SCAAGVTISSVEKKLMAFQPAPKVIRCMT------NTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVG-FCTEVEEDLIDAVTGLSGSGPAYAFM-ALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHLKDNVCSPGGATIHALHFLESGGINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTLTPSSPGKLLTRSL..... 313
12 -15.600[E] COG0345 Pyrroline-5-carboxylate reductase  ali follow..  15  1MENQKIGFIGAGKM--------------GSALMQG--TIKAGIVTPENIGASDVYEPFLKDLQA----KLGIRVSTDNAVIVRESDILILAVK-PQTLSSVLSNLKNEITSEKLVISIAA--------PLSTYEDALLEGTRVVRVMP------NIAATVSEAASGIAPGKNATPEDLKAALEIFSAVG-TAVQVPESLMDAVTGLSGSGPAFIFP-VIEAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETGMHLKDMVTSPATTIQGIHSLEEAGIRAAFMNAVIRASERSKELGK............................................ 269
13 -14.600[S] COG5495 Uncharacterized conserved protein  ali follow..  13  10.ARLNIAILSTGR------------------------VGVALERADQVVVACSAVSHASRQWVQFRL---PETSVASPPEVASSAELLLLAVP-DCEFAGLMSGVAVTPRPGTIVAHTSWANG------VGILAQLGKDGCIPLAIHPAMMSGSDEDLSQCQLRDTYFGITKTDDVGYAIAQSLVLEMGGEPFCVVEYAHSVSPHVGNHIVTVLADALEVRRSALRGSELLGLGVPPACRGEVVDDQLDVIVERIVGSLARAACENTLQRGQAGLVARGDLDALAGHLVALMRIGPELAQAYRVNALRKTQRAHAPYDVVE....................... 305
14 -12.000[M] COG1004 Predicted UDP-glucose 6-dehydrogenase  ali follow..  13  1...MKVTVFGIG-----------------VGLVQATVLA----EVGHDVLCIDIDANKLAPLVKENYEAGRLQFSTDAQAGVAHGVIQFIAVGTPKYVLDVASTIGTYMDSPKVIIDKSTVPVGTADKVHQVIQAILEQ----VVSNPEFLKEGAAVADCKRPERIVIGIDTDDSGALELISELYEPFHDRMLVMDIRSAELTKYAANGMLATKISFMNEIANIAERLGADIEKVRQGI......................................................................................................... 247
15 -11.800[I] KOG2304 3-hydroxyacyl-CoA dehydrogenase  ali follow..  12  24....NVTIIGAGLM--------------------GSGIAQVSANAKLNVTVVDSNQSALEKAQQGSSVLDRIKMSTNVSDSVKDADLVIEAIVENDIKRKLFAEVEVAAKPTTLITNTSSLRLADIGLNLKDKSR-------FGGLH---------NPVPMMKLLEVVRHTETSDATFNQLVDYGKTVGKTTVACKDTPGFIVNRLLVPYMFEALRLYERGDASMEDI.................................................................................................................... 239
16 -11.800[M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase  ali follow..  11  1.......MIDVNTVVEKFKSRQALIGIVGLGYVG--PLMLRYNAIGFDVLGIDIDDVKVDKLNAGQCARASGFEATTDFSRVSECDALILCVPTPSFVINTTDALKPYLRVGQVVSLESTTTEEELLPRVQEGGLVVGRDIYLVYSPEREDPGNPNFETRTIPKVIG----GHTPQCLEVGIALYEQAIDRVVPVSSTKAAEMTKLLENIHRAVNIGLVNEMKIVADRMGIDIFEVVDAAATK..................................................................................................... 256
17 -11.500[S] COG1255 Uncharacterized protein conserved in archaea  ali follow..  18  16....KVIEVGIGF---------------------YTRIAKRLKELGFDVLAIDINKDAVVNAKNSGLNAEVDDIFNPNISLYMGAKAIYSIRPTPE-MMNYILKISKAVKVPAYIV.................................................................................................................................................................................................................................... 105
18 -11.200[I] COG1250 3-hydroxyacyl-CoA dehydrogenase  ali follow..  14  4....TVGIIGAGQM--------------------GCGIAHVSAAAGYKVQLYDIAADRIEAGLEDRKRALSLIKGSGDINDLAQADLVIEAVTEDTVKRKIYGQVCPVMRPDAILTNTSSLSITRLASATDRPER-------FMGIH---------NPVPVMKLVELVRGIATEEETFKAAKEFVAHLDKTVTVAEDFPAFIVNRILLPMINEAIYTLYEGVGTVDAI.................................................................................................................... 213
19 -11.000[R] COG2910 Putative NADH-flavin reductase  ali follow..  13  2...AKIALIG------------------ASGNAG-SRILKELSDRGHQVTAIARNPEKIAALPNVVAKKGDVFDQAALSELLKGHDAVISSVFTASDPATLIEAVRASGVQRYLVVGGAGS............................................................................................................................................................................................................................... 101
20 -10.600[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  12  2..KQHIGYLGMGI---------------------GFCLASLLANKGYPVVAWSRNPDLIKQLQEERVISPNLSFTTDMKEAIHNAFMIVEGVT-SAGIRPVAEQLKQITDLSVPFVITSNTGLLLSEIMLEVLGDSVTPYLGYLSG-PSIAKEVLNG--------CSVVVSAYDSQTLKQIHEAFSLPTFRVYPNTDIKGAALGGALKNVIAI-ACGIAEGLSFGNNLVTRGLHEMRKLAAIMDCKPETLNGLAGLGDLC-VTCFSESSRNLRFGHLLAQGLTFEQAKAKIGMVVEGAYTALSAYQVAKHHKIDMPITTGIYRVLYENLDLKEGIALLLQR... 327
21 -10.200[C] KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase  ali follow..  13  23.KLISVGIIGSGN---------------------GTAIAKICGENAKQVHMWMYEEKIQHEGKECNLTEVNVFANPDIRDVGSRSDILVWVLP-HQFVVRICNQLKGCLKKDAVAISCIKVTKDRVRLFSDIIEENTGMYCGVLSG-ANIASEVAQEKFCETTIGYLPNSSVNPRYTPKTIQALFNRPYFRVNIVEDVPGVALGGALKNIVAV-AAGIIDGLELGDNTKSA................................................................................................................. 258
22 -9.990[H] COG1893 Ketopantoate reductase  ali follow..  12  1MEKPRVAVIGSGSI--------------------GLLLYAYLKLANWPALLVTNRPEQADHLNKEGLTPISVTATPLSSFSAEEAEVGFITVK-SFAVKALLPQLQRKKWDGLVFFQNGMTHLEILRQIPARAI--------CCGIVEIGAKRESDVRVHTGDGAIWIGDMVGDSKNFDPMWACLHNAGLKAQKVTNWQDKMERKLIANAAINPLTGLFRVKN------------------------GALIENQLFSLLLKELVKEACVTLGREREVDEHLAYTRAICDKTANNLSSMYMDLTHHR--RTEIESITGYLIKEAAKKGTSFVYHAVMGMDEE... 301
23 -9.860[S] COG4408 Uncharacterized protein conserved in bacteria  ali follow..  7  3....KLLMIGTGP--------------------VAIQLANICYLKSDYIDMVGRASTSEKSKRLYQAYKKE-RLYKDVKNVKGEYETVVMACT-ADAYYDTLQQLSLETLQSVKHVILISPTFGSQMIVEQFMSKFSQDIEVISDTRIVDKEAPNHVLTTGVKKKLYMGSTHSNSTMCQRISALAEQLKIQLEVVE----SPLHAETRNSSLYVHPPLF---------------------MNDFSLKAIFEGTDVPVYVYKLFPEGPITMTLIREMRLMWKEMM----AILQAFRVPSVNLLQFMVKENYPVRPETLDEGDIEHFEILPDILQEYLLYVRYTAI 320
24 -9.250[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  12  2...LKIGIVGCGFIGGQICR------------------AIDGGEVSAELYACDSSESKALELAAS--LKTCKPSYMKIEELIRGVDLIIESAS-QNAVRFIVPQA---LKAGCMILSVGALADEELRDTLFGLAKEHNCKLYFPSGA..................................................................................................................................................................................................... 124
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;