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Query: [R] COG4015 Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAVILLEISELEGKKAPRGEVTLVGAGRLGLRTALNLMQIHRGGPERINVIDGQRVSADDLIFRLMGATPGEYKVKFIESLATPGFSRTVRGIPEYIDRDNLHLLRGDVVCVEIAGGDTLPVTAEIIKYAQKRGSATISTMGVFGIGEEEVNAISIEEADPGNPIVEYLLDEGVTDHLLVGTGKLIRDWEPVTPYVLDRVSEVMTAEILKLLRRKLGLast
1 -83.900[R] COG4015 Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family  ali  100  1MAVILLEISELEGKKAPRGEVTLVGAGRLGLRTALNLMQIHRGGPERINVIDGQRVSADDLIFRLMGATPGEYKVKFIESLATPGFSRTVRGIPEYIDRDNLHLLRGDVVCVEIAGGDTLPVTAEIIKYAQKRGSATISTMGVFGIGEEEVNAISIEEADPGNPIVEYLLDEGVTDHLLVGTGKLIRDWEPVTPYVLDRVSEVMTAEILKLLRRKLG 217
2 -61.200[H] COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1  ali follow..  17  18FGGTRRLYGYDEVDILRAAHVCVIGIGGVGSWAVEALA---RTGIGELTLIDMDDVCVTNINRQIHAGTIGKSKIEVMERVKLINPECKVNLVDDFITPDNQHLYLNKSFDYVLDAIDSLKAKASLLAYCRSNKIKVITVGGAGGQTDPTQITVADLTKTIQDPLAKKLKDRLRQHARKFGIDCVFSTEQGAATVVTATFGFVAVARIVDKLIQK.. 268
3 -56.300[O] KOG2018 Predicted dinucleotide-utilizing enzyme involved in molybdopterin and thiamine biosynthesis  ali follow..  15  109LARNYAFFGEDGMERLRNSFVIVVGCGGVGSWVINMLA---RSGVQKIRIVDFDQVSLSSLNRHSIAQDVGTPKTLAIKAIKKFAPWIEVDARNALFNPDSADDLLSGNPDFVIDAIDNIQTKVDLLSYCYNHKLPVIASTGSACKSDPTRVNIADISATSEDPLSRATRRRLRLLGIMEGIPVVFSTEKPVIGPMPGIFGLTIATYVLTSIAKY.. 358
4 -55.300[H] KOG2017 Molybdopterin synthase sulfurylase  ali follow..  17  75.QLLLPSFAVEGQSNLLKSSVLVIGAGGLGSPALLYLAA---CGVGQLGIIDHDVVELNNMHRQIIHTFIGHPKVKSAAACRSINSTIKVDEYVEALRTSNALEILSQ-YDIIVDATDNPPSRYMISDCCVLLGKPLVSGAALGMEGQLTVY------NHNGGPCYRCLFPTPPPTSACQR-----CSDSGVLGVVPGVIGCLQALETIKLASL... 275
5 -41.800[H] KOG2337 Ubiquitin activating E1 enzyme-like protein  ali follow..  14  319.LMRWRLVPQLDLDRIQNSKCLLLGAGTLGCGVARNLLS---WGVRHVTFVDYSTVSYSNPVRQSLFTF-KLPKAECAQRLKEIYPNMFSTGYNISIDYETLENLIST-HDAIFLLTDTRESRWLPTVISTAMDKLLINSALGFDSWLVMRHGSVLQKENRL-GCYFCNDIFAPSNSLVDRT---LDQTCTVTRSGCANIATAIAVELFVSLLQH.. 546
6 -40.400[O] KOG2013 SMT3/SUMO-activating complex, catalytic component UBA2  ali follow..  12  9.NDMKPLTFVEALRNFKSAKVLLVGAGGIGCELLKNLLM---SGVKEVHIIDLDTIDLSNLNRQFLFRHVKQPKAIVAKTASSFNPNVKLEAYHANIKEDRFNVAWFRQFDLVFNALDNLDARRHVNKQCLLASVPLIESGTTGFLGQVQVII------HGKTECYDCNPKEPPKT-------YPVCTIRSTPSQPIHCVVWAKSYFFPQLFSND.. 209
7 -40.000[H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2  ali follow..  13  124LQRQALAFGEALNQDLSMLRVGVIGCGGTGSAIAMLLP---KMGIRNIALFDKDIVEDTNLNRLHGARDAMSPKVEVVAKLVELGLGVQVRTYQAWIGEADCRDPLKA-CDVIFCCTDDHTGRLMLNRFAYYYATPVFDMGLAIEVSQGET-RVTVLVPAPGHACLLCRLKRSNPDEYERRKAEAYVIGEGNPSPAVVLFTTEVAIMAMQELVHR.. 358
8 -38.300[O] KOG2015 NEDD8-activating complex, catalytic component UBA3  ali follow..  13  25YKVPWFVPGPENFEALQNTKILVIGAGGLGCELLKNLAL---SGFRTIEVIDMDTIDVSNLNRQFLFSDVGKSKAEVAAFVQQRVVGCQNYFNFISIFRHNCRI-FYRKFSIIICGLDSIPARRWINGMLCNTIIPMIDGGTEGFKGNARVIYPK------FTACIDCTLDLYPPQVNFP-----LCTIAHTPRLPEHCIEYIKVVVWPE....... 241
9 -33.500[O] KOG2014 SMT3/SUMO-activating complex, AOS1/RAD31 component  ali follow..  8  15.DRQIRVWGANAQRRLTKAHILVSGIKGTVAEFCKNIVL---AGVGSVTLMDDRLANMEALNANFLIPPSGKTVAEICDSLKDFNPMVRVSVEKGDLSMLGTDFF--EQFDVVVIGYGSRATKKYVNEKCRKLKKRVAFYTV........................................................................... 156
10 -32.700[O] KOG2016 NEDD8-activating complex, APP-BP1/UBA5 component  ali follow..  15  14.DRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVL---PGIGSFTIIDGNQVSGEDAGNNFFLSSIGKNRAEAAEFLQELNSDVSGSFVEESPENDNDPSFFCR-FTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRII................................................................. 165
11 -12.600[Q] COG5310 Homospermidine synthase  ali follow..  12  1...MLDKMANENWPVYGTGPVVMIGFGSIGRGTLPLIERHFKFDKSRMTVLDPRD--------------------TDRKLLDERGIAFVQEAVTENNYKKLLTPLLTGGQGFCVNLSVDTGS-VDLMRLCRKLGVLYIDTVVEPWLGFYFDAKADNASRTN------ALREAMIKEKHDKPGGATVVSTCGANPGMVSWFVKQALVNLATD...... 186
12 -10.200[E] COG1748 Saccharopine dehydrogenase and related proteins  ali follow..  10  2.................KKNVLIIGAGGVAQVVAHKCAQNSDVL-GDIHIASRTVDKCRKIVESV-EVKLEAHALDALDVIVSTGSQIVINVGSAFVNMSVLRACMDTGVAY-MDTAIHGNYEWKRAAECKEKGITAILGVGF.......................................................................... 151
13 -9.360[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  13  3...................KIGIVGCGFIGGQICRAIDG-GEVSAELYALCDSSESKALELAASLKTCKPSYMKIEELIR----GVDLIIESASQNAVRFIVPQALKAGCDVMILALADEELRDTLFGLAKEHNCKLYFPSGA.......................................................................... 124
14 -9.070[E] COG4091 Predicted homoserine dehydrogenase  ali follow..  15  11.........AARAETGKPIRIGLIGAGEMGTDIVTQVARM--QGIEVGALSARRLPNTFKAIRT-----AYGDEENARGATTESAMTRAIEAGKIAVTDDNDLILSNPLIDVIIDATGIPEVGAETGIAAIRNGKHLVMMN............................................................................ 135
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.