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Query: [C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MIDMKLAILGAGCYRTHAASGITNFSRACEVAEMVGKPEIAMTHSTITMGAELKELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKVNEVAKELPKPPEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDMQPGIIDKFIDDIKPGAIVTHACTIPTTKFYKIFEEKHGDLVTKPETLNVTSYHPGAVPEMKGQVYIAEGYASEEAINTLFELGQKARGNAYRLPAELLGPVCDMCSALTAITYAGILSYRDSVTQVLGAPAGFAQMMAKESLEQITALMEKVGIDKMEEHLDPGALLGTADSMNFGASADILPTVFEILEKRKKLast
1 -98.900[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali  100  1MIDMKLAILGAGCYRTHAASGITNFSRACEVAEMVGKPEIAMTHSTITMGAELKELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKVNEVAKELPKPPEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDMQPGIIDKFIDDIKPGAIVTHACTIPTTKFYKIFEEKHGDLVTKPETLNVTSYHPGAVPEMKGQVYIAEGYASEEAINTLFELGQKARGNAYRLPAELLGPVCDMCSALTAITYAGILSYRDSVTQVLGAPAGFAQMMAKESLEQITALMEKVGIDKMEEHLDPGALLGTADSMNFGASADILPTVFEILEKRKK 347
2 -42.800[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  25  1MSTMKVAVYGAGNQKLYVDQ---------------------------LNLPEKYGGEAPYGSRMAIEFAEAGHDVVLAEPARDML------------------------------DDAHWKVVEDAGVTVTDNDAEAASEAEIAVLFTPFGKKTFEIAKNITNHLPEGAVIANTCTVSPVVLYYVLE---RELRRDRKDLGIASMHPAAVPGTPGHSSSELDIATDEQISRCVELAESCGKVAYVVPADVSSAVADMGSLVTAVTLSGVLDYYYVGTQIIRAPKEMVEKQILMTLQTIASLVETSGVNGMLKAMNPELLVRSAKSMHLLEEQEELDAALNTLSDLDD 296
3 -36.400[E] COG0287 Prephenate dehydrogenase  ali follow..  16  1..........................................................................MMGDIMFERIALIGIGLIGSSIARDVRE-LGLARHVVISTRSEDTLKRAEELALDYTVSAAEAVKDADLVIVSVPVGASE-SVAQQIAPYLKPSAIVTDVGSTKASVIAQMAPHM-------PENVHFIPGHPLAGTEKSGPDFTPLPGTDAAALERLKDFWRALGSRVDEMDAEHHDKVLAIVSHLPHIIAYNIVGTADDLETVTESE---VIKYSASGFRDFTRLAASDPMWRDVCLHNKDAILEDLASLQRAIRWGEGDKLFELFSRTRS 284
4 -32.600[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  7  1MAETLITKPPLSLSFTSLSSMLPSLSLSTHLSVTDTIPLPNSNSNATPPLRIAIIGFGNYGQFLAETLISQGHILFAHSRSDHS------------------------------------SAARRLGVSYFTDLHDCERHPDVVLLCTSILSIENILKTLPFQRLRRNTLFVDVLSVKEFAKTLLLQYL-------PEDFDILCTHPMFGPQSVSSNRIGEERLRVSRCESFLEIFVREGCEMVEMSVTDHDKFAAESQFITHTLGRLLGMLKLIST-------PINTKGYEALLDLAENICGDSDLYYGLFVYNNNSIDLAFEALRKELFSRLHGVVRKQSFEGEA 321
5 -32.600[I] KOG2304 3-hydroxyacyl-CoA dehydrogenase  ali follow..  11  13.......................................LSTTAQLSKINNVTIIGAGLMGSGIAQVSANAKLNVTVVDSNQSALEKAQQGIANSLKRVAKKKH------ADDAAAQTALVSSVLDRIKMSTNVSDSVKDADLVIEAIVENDIKRKLFAEVEVAAKPTTLITNTSSLRLADIGLNLKDKS-------RFGGLHFFNPV--PMMKLLEVVRHTETSDATFNQLVDYGKTVGKTTVACK-DTPGFIVNRLLVPYMFEALRLYERGDASMEDIDVPMGPFELSDYVGLDTCKFIMDGHAQYPEEVAFTPSPLLNSLVDSGKNGRKSG-EGFYKY...... 308
6 -31.600[I] COG1250 3-hydroxyacyl-CoA dehydrogenase  ali follow..  12  1...............................................MIKTVGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEAGLATINGNLARQVSS-------------GKMSDEDRKRALSLIKSGDINDLAQADLVIEAVTEDTVKRKIYGQVCPVMRPDAILTNTSSLSITRLASATDRPE-------RFMGIHFMNPV--PVMKLVELVRGIATEEETFKAAKEFVAHLDKTVTVAE-DFPAFIVNRILLPMINEAIYTLYEGVGTVDAIDTPMGPLQLADFIGLDTCLSIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKSG-RGFYDYRGEVPV 287
7 -22.100[I] KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase  ali follow..  11  298.....LDVVRTAYLDPKNG--AKAFGELSQTFQSKALFGLFEGSTNAKVNEIAVVGAGFMGAGIANVTINKGIRTVLLDANQAGVERGQNHVATHLNRQLKR-------------QKISKLEREKIYNHLVPTIDSAMKNADVVIEAVFEDPLKHKVIRQIENVVGPNTIISNTSALPIKDIAAASSRSD-------KVIGMHYFSPV--EKMQLLEIITHDGTSKETLATAAQLGLKQGKLVVVVK-DCPGFFVVRCLSPMMSEIVRLLQELDKLTTKFGFPVGAATLADEAGLDVAEHVARYGTALGPRVHGGSVDLLSELVRAGHKGRKTS-KGIFVYGDGAKG 636
8 -14.600[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  8  1...MQLGMIGLG----------------------------------------------RMGANIVRRLAKGGHDCVVYDHDPDAV-------------------------------KAMAGEDRTTGVASLRELSQRLSAPRVVWVMVPAGNITTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFK------KGIHLLDCGTSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGV........................................................................................................ 157
9 -14.400[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  11  1................................................METIGFIGLGIMGAPMAGHLLDAGYKVIA------------------------------------DHRSKPLADLVAKGLKTVSGHAAVAKAADIIITMVPDTPQVADVLNGVASGLTRGKLVIDMSSISPIETKVFAGKINE------LGCDYLDA-PVSGGEVGAKALTIMVGGEEKAFERAKPVFEKMGKNITLVGPNGVGQTTKVANQIVVALTIEAVAEALVFASKAG.................................................................. 196
10 -13.700[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  9  1MANYFNTL------------NLRQKLDQLGRCRFMDREEFADEANFLKGKKIVIVGCGAQGLNQGLNMRDSGLDIS-----------------------------YALRPEAIAEKRASFQRATENGFKVG-TYEELIPTADLVVNLTPDKQHS-KVVADVMPLMKKDSAFGYSHGFNIVEVGEEI----------RKDITVVMVAPKRGFGVPTLIAVHPENDKGEGMAIAKAWAAATGGHKASSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKLVADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELAEQIKEGFLYYKHMDDIISGH. 311
11 -11.900[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  17  6...PSIAILGAG----------------------------------------------RVGSSLARSAVAAGYEVKV----------AGSGAVDKIALTAEILMPGAV----------------------PSTADQAVKDADIVFLAVPLHK-----FRSVNPATLEGKIVIDTMN-PRSTSEIIAEFFAGS--TMVKSFNHIGYHEIEQDAGTGRAIAYAT-DDVDAGAQVAQLIKSFGFVPLNIGALENGRILEPGQEA...................................................................................... 191
12 -10.900[E] COG0345 Pyrroline-5-carboxylate reductase  ali follow..  15  1MENQKIGFIGAGKM------------------------------------------GSALMQGTIKAGIVTPENIGASDVYEPFLK----------------------------------DLQAKLGIRVSTDNAVIVRESDILILAVK-PQTLSSVLSNLKNEITSEKLVISIAAVPLSTYEDALLEGTRVVRVMPNIAATVS--------EAASGIAPGKNATPEDLKAALEIFSAVG-TAVQVPESLMDAVTGLSGSGPAFIFP-VIEAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETG-------MHPGELKDMVTS...................... 232
13 -10.700[E] KOG3124 Pyrroline-5-carboxylate reductase  ali follow..  16  1...MSVGFIGAG----------------------------------------------QLAYALARGFTAAGI-----------------------------LSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETVKHSDVLFLAVK-PHIIPFILDEIGADVQARHIVV---SCAAGVTISSVEKKLMAFQPAPKVIRCMTNTPVVV-QEGATVYATGTHALVEDGQLLEQLMSSVG-FCTEVEEDLIDAVTGLSGSGPAYAFM-ALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSE-------QHPCQLKDNVCS...................... 233
14 -10.600[M] COG1004 Predicted UDP-glucose 6-dehydrogenase  ali follow..  11  1...MKVTVFGIG-----------------------------------------------VGLVQATVLAEVGHDVLCIDIDANKV---------------ADLKKGRIAIFEPGLAPLVKENYEAGRLQFSTDAQAGVAHGVIQFIAVGTPKYVLDVASTIGTYMDSPKVIIDKSTVPVGTADKVHQVIQAILEQRGEKIDFVVSNPEFLKEGAAVAVIGIDTDDSGALELISELYEPFNHDRMLVMDIRSAELTKYAANGMLATKISFMNEIANIAERLG.................................................................. 237
15 -9.760[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  11  8......................................................IGLAVMGQNLILNAADHGFTVCAYNRTQSKVD------------------------------HFLANEAKGKSIIGATSIEDFISKLKRVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKK------KGILFVGSGVSGGEEGARYGPSLMPGGSEEAWPHIKNIFQSISAKCEWVGPAGAGHYVKMVNGIEYGDMQLICEAYDIMKR..................................................................... 205
16 -9.760[K] KOG0067 Transcription factor CtBP  ali follow..  12  111.VDIKAA--ELGIAVCNIPSAAVE-----ETADSTICHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIR-----ETLGLIGFGRTGQAVAVRAKAFGFSVI---------LQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLIDFTIKQMRQGAFLVNAARGGLVDEKALAQALKE--RIRGAALDVHESEPF-GPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRA..................................................................................................... 344
17 -9.690[S] COG5495 Uncharacterized conserved protein  ali follow..  7  13..................................................................................NIAILSTGRVGVALERADQVVVACSAVSHASRQ-----WVQFRLPETSVASPPEVASSAELLLLAVPDCEF-AGLMSGVAVTPRPGTIVAHTSANGVGILAQLGK----------DGCIPLAIHPAMMEDLSQCQLFGITKTDDVGYAIAQSLVLEMGGEPFCVVEYA--------RILYHSVSPHVGNHIVTVLADALEVRRSALRGSELLGLGVPPACRGEVVDDQLDVIVERIVGSLARAACENTLQRGQAGLTKLVARGD. 264
18 -9.680[G] COG0362 6-phosphogluconate dehydrogenase  ali follow..  9  10......................................................IGLAVMGQNLILNMNDHGFKVVAYNRTTSKV------------------------------DEFLQGAAKGTNIIGAYSLEDLAAKLEKVMLMVRAGDVVDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAE------KGIRFIGSGVSGGEEGARHGPSIMPGGNQEAWQYVKPIFQAISAKCDWVGGEGAGHFVKMVNGIEYGDMQLICEAYQFLKE..................................................................... 208
19 -9.420[S] COG4408 Uncharacterized protein conserved in bacteria  ali follow..  7  1................................................MSKLLMIGTGPVAIQLANICYLKSDYEIDMVGRASTSEKSKRLYQA-----YKKEKQFEVKIQNEAHQHLEGKFEIN---RLYKDVKNVKGEYETVVMACT-ADAYYDTLQQLSLETLQSVKHVILISPTFGSQMIVEQFMSSTYLGDTRIVDKEAPNHVLTTGVKKKLYMGSTHSNSTMCQRISALAEQLKIQLEVVE-SPLHAETRNSSLYVH.................................................................................... 216
20 -9.170[M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase  ali follow..  10  8.........................................VEKFKSRQALIGIVGLGYVGLPLMLRYNAIGFDVLGIDIDDV-----------KVDKLNAGQCYI------EHIPQAKIAKARASGFEATTDF-SRVSECDALILCVPTPSFVINTTDALKPYLRVGQVVSLESTTYPGTTEEELLPRVQEGGLVVGRDIYLVYSP-EDPGNPNFETRTIPKHTPQCLEVGIALYEQAIDRVVPVSSTKAAEMTKLLENIHRAVNIGLVNEMKIVADRMG.................................................................. 243
21 -9.140[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  10  3.................................................QHIGYLGMGIWGFCLASLLANKGYPVV----------------------AWSRNPDLIKQLQEERRHPLAPNVVISPNLSFTTDMKEAIHNAFMIVEGVT-SAGIRPVAEQLKQITDLSVPFVITSGIEQNTGLLLSEIMLEVLGDSVTPYLGYLSGPSIAKEVL--CSVVVSAYDSQTLKQIHEAFSLPTFRVYPNTDIKGAALGGALKNVIAIAC--------GIAEGLSFGNNAKAGLVTRGLHEMRKL.............................................. 226
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Liu T, Rojas A, Ye Y, Godzik A. Homology modeling provides insights into the binding mode of the PAAD/DAPIN/pyrin domain, a fourth member of the CARD/DD/DED domain family. Protein Sci. 2003 Sep;12(9):1872-81.