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Query: [E] COG4091 Predicted homoserine dehydrogenase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MALVGLARDLAARAETGKPIRIGLIGAGEMGTDIVTQVARMQGIEVGALSARRLPNTFKAIRTAYGDEENARGATTESAMTRAIEAGKIAVTDDNDLILSNPLIDVIIDATGIPEVGAETGIAAIRNGKHLVMMNVEADVTIGPYLKAQADKQGVIYSLGAGDEPSSCMELIEFVSALGYEVVSAGKGKNNPLNFDATPDDYRQEADRRNMNVRLLVEFIDGSKTMVEMAAIANATGLVPDIAGMHGPRASIDQLSHTLIPQAEGGVLSKSGVVDYSIGKGVSPGVFVVAKMDHPRLNERLEDLKIGKGPYFTFHRPYHLTSLEVPLTVARVVLHGKTDMVPLPKPVAEVCAVAKKDMQPGEHLDAIGQYCYRSWIMTVPEARAAKAIPCGLLQNGTVIAPIKKGELITYANAAPQPGSRIAELRALQDAMLGQLast
1 -106.000[E] COG4091 Predicted homoserine dehydrogenase  ali  100  1MALVGLARDLAARAETGKPIRIGLIGAGEMGTDIVTQVARMQGIEVGALSARRLPNTFKAIRTAYGDEENARGATTESAMTRAIEAGKIAVTDDNDLILSNPLIDVIIDATGIPEVGAETGIAAIRNGKHLVMMNVEADVTIGPYLKAQADKQGVIYSLGAGDEPSSCMELIEFVSALGYEVVSAGKGKNNPLNFDATPDDYRQEADRRNMNVRLLVEFIDGSKTMVEMAAIANATGLVPDIAGMHGPRASIDQLSHTLIPQAEGGVLSKSGVVDYSIGKGVSPGVFVVAKMDHPRLNERLEDLKIGKGPYFTFHRPYHLTSLEVPLTVARVVLHGKTDMVPLPKPVAEVCAVAKKDMQPGEHLDAIGQYCYRSWIMTVPEARAAKAIPCGLLQNGTVIAPIKKGELITYANAAPQPGSRIAELRALQDAMLGQ 434
2 -28.200[E] KOG0455 Homoserine dehydrogenase  ali follow..  11  2...............STKVVNVAVIGAGVVGSAFLDQLLAMKS-TITYNLVLLAEAERSLISKDFSPLN---VGSDWKAALAASTTKTLPLDDLIAHLKTSPKPVILVDNTSSAYI-AGFYTKFVENGISIATPNKKAFSSDLATWKALNKPTNGFVYHEATVGAGLIISFLREIIQTGDEVEKIEGIFSGTLSYIFNFSDVVKVAKKLGYTEPDPRDDLNGLDVARKVTIVGRISGVEFPVQSLIPKPLESVKSADEFLEKLSDYDKDLTQLKKEAATEN-----FIGKVDVATKSVSVGIEKYDYSHPFASLKGSDNVISIKTKRYTNPVVIQGGAGAAVTAAGVLGDVIKIAQRL............................................................................ 359
3 -27.900[E] COG0460 Homoserine dehydrogenase  ali follow..  12  7...............SKHFLDVFVVGVGGVGGELVDQIQRQQAMRVCGLANSK----GMLLDSQGLPLEQWR--------DRMINADQAFSLENLVALVNHIINPVLVDCTSSDEIANQYA-DFLAAGFHVVTPNKKANTAYYHQLRNVARHSRRKLMYETTVGAGLVIENLQNLIAAGDELEKFSGILSGSLSFIFGLSQATQLAKEKGFTEPDPRDDLSGMDVARKLLILAREAGYELELSDVDVEQALPAGFDASGSVEEFMARLAQA-FAERVAQAKAEGKVLRYVAQIVDGQCQVRIVAVDENDPMFKVKEGENALAFYSRYPIPLVLRGYGAGSEVTAAGVFSDVMRTLGWKL........................................................................... 362
4 -19.700[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  15  2...................LKIGIVGCGFIGGQICRAIDGEVSAELYALCDSSESKALELAASLK---------------------TCKPSYMKIEELIR--GVDLIIESAS-QNAVRFIVPQALKAGCDVMILSVGALADLRDTLFGLAKEHNCKLYFPSG................................................................................................................................................................................................................................................................................ 123
5 -17.200[R] KOG2742 Predicted oxidoreductase  ali follow..  21  3...................PGVGVFGTGEIANVLVPLLRE-KGFEVRAIWGRTLKEAKETATTQNVQF----------------------HTNVIDDVLLRKDVDLVFIVCQP-FLHAEISVKALGIGKHVVCDKPGLHQQDALKMVRASQYYPTLISLVN................................................................................................................................................................................................................................................................................. 121
6 -16.500[R] COG0673 Predicted dehydrogenases and related proteins  ali follow..  25  2.................KTVNIGLIGAGRIGQLHASNIISSPYMELKAVSDVQLDHLKGTEIERSVEI----------------------MTTNPDELFSNRDIDAIFICSST-DTHAAFIKAAALAGKHIFCEKPSFHVTETKGALNIVNEAGVKFQVG.................................................................................................................................................................................................................................................................................. 122
7 -15.700[Q] COG4569 Acetaldehyde dehydrogenase (acetylating)  ali follow..  15  2.................SKRKVAIIGSGNIGTDLMIKIRHGQHLEMAVMVGIDPQS---------------------DGLARARRMGVATTHEGVIGLMNMPDIDIVFDATSA-GAHVKNDAALREAKPDIRLIDLTGPYCVPVVNLEANVDQLNVNMVTCGGQATIPM......................................................................................................................................................................................................................................................................... 139
8 -15.200[GQ] KOG2741 Dimeric dihydrodiol dehydrogenase  ali follow..  14  2..............SGDNQIRIGLLSCTNKVRKLSRAINLSPNATISAIATTSIEEAKSFAKSNNFPPNTK-------------------LHSSYESLLEDPDVDAVYFPIPT-RLHVEWATLAAIKGKHILLDKPALNVAEFDQIVEACEVNGVQFMDG.................................................................................................................................................................................................................................................................................. 129
9 -15.200[E] COG1748 Saccharopine dehydrogenase and related proteins  ali follow..  12  2..................KKNVLIIGAGGVAQVVAHKCAQNSDVLGIHIASRTVDKCRKIVESVREKKSLKTEVKLEAHALDALD------VEATKALIVSTGSQIVINVGS-AFVNMSVLRACMDTGVAYMDTAIHEEPNKI-KRAAECKEKGITAILGVGFDPGVVNAYARLA................................................................................................................................................................................................................................................................... 163
10 -15.200[Q] COG4693 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis  ali follow..  15  2............MPSASPKQRVLIVGAK-FGEMYLNAFMQPPELELVGLLAQGSARSRELAHAFGIP-----------------------LYTSPEQITRMPDIACIVVRSTVAGTGTQLARHFLTRGVHVI-QEHPLHPDDISSLQTLAQEQGCCYWVN.................................................................................................................................................................................................................................................................................. 126
11 -14.400[S] COG3804 Uncharacterized conserved protein related to dihydrodipicolinate reductase  ali follow..  13  2..................AIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAKDAAELAGLA-----------------DSTGVRASTDLNAVLATGPRCAVYNAMNRLPEALEDYRRILAAGINIVGSGPVFPDEIIKPLQDAARAGNSSL-YVNGIDPGFANDLLPMALAGTCE--SIEQIRCMEIVDYATYDSAVVMFDVMGFGKPMDQIPMLLQPGVLSVRQLAAGLGISLD................................................................................................................................................................................................. 221
12 -11.300[Q] COG5310 Homospermidine synthase  ali follow..  6  1..MLDKMANENWPVYGEITGPVVMIGFGSIGRGTLPLIERHFKFDKMTVLDPRDTDRKLLDERGIAFVQEAVTENNYKKLLTPL-------------LTNGGGQGFCVNLSVDTG-SVDLMRLCRKLGVLYIASRTNYALREAMIKEKHDKPGGATVVSTCGANPGMVSWFVKQA................................................................................................................................................................................................................................................................... 179
13 -10.300[E] KOG0172 Lysine-ketoglutarate reductase/saccharopine dehydrogenase  ali follow..  12  472..........AQSLSMGTRRKVLVLGSGYISEPVLEYLSRDGNIEIT-VGSDMKNQIEQLGKKYNINPVSMDICKQEEKLGFLVA-----------------KQDLVISLLPY-VLHPLVAKACITNKVNMVTASYITPALK--ELEKSVEDAGITIIGELGLDPGLAMETIDKAKEVGATIESY-EHSNNPLRYKFSWSPLMNVMQSATYLLDGKVVNVAGGISFLDLEGYPNRDSTKSSAHTLLRGTLRYKGYMKALNG------FVKLGLINREALPAFRPEANPLISPSSEHDVLKEAVLKKLGGDNTQLEAAEWLGLLGSILDALSKHLVMKLSYGPEEKDMIVMRDSFGIRHPSGHLEHKTIDLVAYGDINGFSAMAKTVGLPTAMAAKMLLDGEIGAKGLMGPFSKEI--GPILERIKAE....... 914
14 -10.300[I] COG0743 1-deoxy-D-xylulose 5-phosphate reductoisomerase  ali follow..  12  3....................QLTILGTGSIGNSTLSVVRANPEFKVTALAGRNVREMAQQCLEFSPRYAAMSDEHSAKSLRLLLAEQGSDTETAACELAALDDVDQVMAAIVGI-AGLPSTLAAIRAGKQVLLANKESLITCGKLFMDEVKRSRAQLLPIDSEHNAIFQSLLGYSSLNENGVSRIILTGSGGPFRETPLSQFSDVTPDQACAHPNWSM---GRKISVDSATMMNKFNASAEQIEV----LHPQSVIHSMVRYHDGSILAQMGTPDMRTPIAHA....................................................................................................................................................... 283
15 -9.700[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  13  2...............SHTKPSIAILGAGRVGSSLARSAVAA-GYEVKVAGSGAVDKIALTAEILMPGA-------VPSTADQAVKDADIVFLAVPLHKFRSVNPAIVIDTMNQDPRSTSEIIAEFFAGSTMV---KSFNHIGYHEIEQDAGTGRAIAY--ATDDVDAGAQVAQLIKSFGFVPLNIGALENG................................................................................................................................................................................................................................................... 182
16 -9.330[E] COG0289 Dihydrodipicolinate reductase  ali follow..  24  2..................TLKIAIAGAGRMGCQLIQAVHSAEGVELGAAFERKGSSL----------------VGTDAGELAGIGHLGVAVSDDLESQKD--KFDLLIDFT-RPEGTLEHIAFCVANNKKMVIGTTGFDENGKVAIKAASDKIAIVFASNFSVGVNLVFKLLEKAAKV................................................................................................................................................................................................................................................................ 143
17 -9.160[S] COG3268 Uncharacterized conserved protein  ali follow..  17  1............MSPDKREFDIVLYGAGFSGKLTAEHLALSESTARIALAGRSSERLRNVRALLGPNAQDWPLIVADASQPSTLEA--------------AGRAQVVLTTVG-TRYGLPLVAACARTGTDYADLTGELMFCR-DLHHKQAAATGARIILACG................................................................................................................................................................................................................................................................................ 141
18 -9.070[R] COG4015 Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family  ali follow..  15  10..........ELEGKKAPRGEVTLVGAGRLGLRTALNLMQIGGPERINVIDGQRVSADDLIFRPGEYKVKFIESLATPGFSRTVRGIPEYIDRDNLHLLRGDVVCVEIAGGDTLPVTAEIIKYAQKRGSATISTM........................................................................................................................................................................................................................................................................................................... 141
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lukasz Jaroszewski, Zhanwen Li, S. Sri Krishna, Constantina Bakolitsa, John Wooley, Ashley M. Deacon, Ian A. Wilson, Adam Godzik, Exploration of Uncharted Regions of the Protein Universe. Plos Biology. 2009 Sep. 7(9):e1000205