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Query: [H] COG4143 ABC-type thiamine transport system, periplasmic component, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLKKYLPLLLLCAAPAFAKPVLTVYTYDSFAADWGPGPAVKKAFEADCNCELKLVALEDGVSLLNRLRMEGKNSKADVVLGLDNNLLEAATQTKLFAKSGVANEAVKVPGGWKNDTFVPFDYGYFAFVYDKSKLKNPPKSLKELVESDQKWRVIYQDPRTSTPGLGLLLWMRKVYGDNAPQAWQKLAAKTVTVTKGWSEAYGLFLKGESDLVLSYTTSPAYHIIEEKKDNYAAANFSEGHYLQVEVAARTVASKQPELAEKFLKFMVSPAFQNAIPTGNWMYPVADVALPAGFESLAKPATTLEFTPQQVAAQRQAWISEWQRAVSRLast
1 -117.000[H] COG4143 ABC-type thiamine transport system, periplasmic component  ali  100  1MLKKYLPLLLLCAAPAFAKPVLTVYTYDSFAADWGPGPAVKKAFEADCNCELKLVALEDGVSLLNRLRMEGKNSKADVVLGLDNNLLEAATQTKLFAKSGVANEAVKVPGGWKNDTFVPFDYGYFAFVYDKSKLKNPPKSLKELVESDQKWRVIYQDPRTSTPGLGLLLWMRKVYGDNAPQAWQKLAAKTVTVTKGWSEAYGLFLKGESDLVLSYTTSPAYHIIEEKKDNYAAANFSEGHYLQVEVAARTVASKQPELAEKFLKFMVSPAFQNAIPTGNWMYPVADVALPAGFESLAKPATTLEFTPQQVAAQRQAWISEWQRAVSR 327
2 -80.400[P] COG1840 ABC-type Fe3+ transport system, periplasmic component  ali follow..  15  25ISSLLLAGTTLLGVPAHAAGDLNLIC----AADVVICEQMKGDFEKTHDIKVNMVR-MSSGEAYAKIRAEARNPKTDLWWAGTGDPHLQAASENLTLEYKSKMLDQLQDAESAGYKTVGVYAGALGWGYNTDIFKKEPKCWADLLAPELKGEIQIANPNSSGTAYTALASLVQIMGEDAFDYLKKLNGNISQYTKSGSAPVKAAARGETAVGIVFMHD--AVAQTAEGFPVKSVAPCEGTGYEIGSMSIVKGARNLENAKTWYDWALQPDVQSRMKDKSFQLPSNKTAEIPKEAPRFEDIKLINYDFKTYGEKRKALLERWDKDVG. 356
3 -60.800[R] COG4134 ABC-type uncharacterized transport system, periplasmic component  ali follow..  14  1MMRHCGWLLGLLSKNEAKGQTVWFNAWGGDTAINRYLDWVSGEMKTHYAINLKIVRLADAADAVKRIQTEATGGSVDLLW-VNGENFRTLKEANLLQTDWAETLPNWRYVVPTEGAESPWGGAQLTFIARRDVTPQPPQTPQALLEKANPGTVTYPRP-PDFTGTAFLEQLLIMLTAPLWQYLDALHPYLKDFPPSPARMDALLKAGTFRLSLTFNPAHAQQKIASGPASSYSFGFREGMIGNVHFVTIPANANASAAXKVVANFLLSPDAQLRKADPAVWPSVLDPQKLPDGQRETLQSRMPQDLPPVLAEPHAGWVQEWLHRYGT 388
4 -52.000[P] COG1613 ABC-type sulfate transport system, periplasmic component  ali follow..  13  1MSSNSLAGIVKLIGLALADTTILNVSYDP---TRELYKEFNAAFAEKTGETVTITSHGGSGKQARSVI---DGLEADVVTLALEADIDAIAKESGKIP---------ADWKSRFENNSAPYTSTIVFLVRKGNPKA-IKDWGDLVREDVQ--VITPNPKTSGGARWNFLAAWAWA-AKAQEYVAQLFKHVPVLDTGAGATTTFVQRGLGDVLLAWENEAYLSLEELGPDNFDIVTPSISIKAEPPVAGNVDSKGTRKVAEAYLDYLYSDVGQKIAAKHYYR-PFKPELADPKDTARFTELKLVTIDWKEAQPKFFGDGGVFDQIYRP 339
5 -39.300[E] COG0687 Spermidine/putrescine-binding periplasmic protein  ali follow..  15  9LLALTLAGSVAGMAQAADNKVLHVYNWSDY-----IAPDTLEKFTKETGIKVVYDVYDSNEVLEAKLLA--GKSGYDVVVPSN-SFLAKQIKAGVYQKLDKSKLHTLEVSDPGNEHAIPYMWGTIGIGYNPDKVKAPVDSWDLVFKPENIQKLKQCGVSFLDSPTEILPAALHYLGKAAEELFLKIRPYVTYF--HSSKYISDLANGNICVAIGYSGDIYQAKSRKNKVTVKYNIPKEGAGSFFDMVAIPKDAENTEGALAFVNFLMKPEIMAEITDVVQFPNGNAAATPPGIYPSEEVMKKLYTFPDLPAKTQRAMTRSWTKI... 363
6 -38.100[P] COG4150 ABC-type sulfate transport system, periplasmic component  ali follow..  15  14LTHIALFSALILSGVTASATELLNSSYDVS---RELFTALNPGFQAQPGDKLTIQSHAGSSKQALAIL---QGLKADVVTYNQITDVQILHDRGNLIPADWQAR----------PNNSSPFYSTMAFLVRKG--PKNIRNWDDLVREDVK--LVFPNPKTSGNGRYTYLAAWGA--AKTRDWMKRFLKNVEVFDTGGGATTTFVERGLGDVLISFESEVNNIRKEYGSDQYEVIVPPVDILAEFPVAKNVEKNGTEKAAKAYLNYLYSPPAQQVITRFNYR-VYDKAAMEA------AKSQFPDTKLFRVEDQFGSWPQVMSTHFTT 332
7 -34.500[R] COG4588 Accessory colonization factor AcfC, contains ABC-type periplasmic domain  ali follow..  11  1MKKIITLFGACALAFSMANADVNLYGPGGPH---TALKDIANKYSEKTGVKVN-VNFGPQATWFEKAKKDAD----ILFGASDQSALAIASDFGKDFNVSKIK---------------PLYFREAIILTQKGN-PLKIKGLKDLANKKVR--IVVPEGAGKSNTSGTGVWEDMIGRTQDIKTIQNFRNNIVAFVPNSGSARKLFAQDQADAWITWIDWSKSN------PDIGTAVAIEKDLVVYRTFNVIAKEGASKETQDFIAYLSSKEAKEIFKKYGWR.............................................. 249
8 -26.800[H] COG2998 ABC-type tungstate transport system, permease component  ali follow..  12  11TLAAASLILVSYSASSADDARIRLATTTSTY-DSGLLDYLLPKFEQDTGYKVDVI-ATGTGKALKMGE----NGDVDLVMTHAPKAEASFVEAGFGVLPRK------------------LMYNDFVVV-DPAKIADEKNIAKVFENIAKSGAVFISRGDDSGTHKKELGIWAQNKIEPNFGGYRSIGQGM-------GPTLNMASEMQAYTLTDRGT----WLAYNNKLALKILFEGDEQLFNPYQVIIVNPERQYHAAKVFSDWLVNPKGQQLINEFKVNVANADK........................................ 274
9 -25.900[G] COG2182 Maltose-binding periplasmic proteins/domains  ali follow..  12  10LALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGP--DIIF-WAHDRFGGYAQSGLLAEITPDKAFQ-AVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPAKELKAKGKSALMFNLQEPYFTWPLIAADGGYAGLTFLVDLKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATNAQKGEIMPNIPQMSAFWYAV... 369
10 -24.700[P] COG0725 ABC-type molybdate transport system, periplasmic component  ali follow..  14  8LVAGATLSFVIAGHALADEGKITVFAAASLT---NAMQDIAAEYKKEKNVDVV-SSFASSSTLARQIE---AGAPADLFISADQKWMDYAADKKAVDT----------------TTRETLLGNSLVVVAPKASEQKP-DNKTDWIRLLNGGRLAVGDPQHVPAGIYAKEAL------QKLGAWQTLEPKLA-PGEDVRGALALVERNEAPLGIVYGSD----AVASKGVNVVATFPEDSHKKVEYPIAIVEGHKNAT-VSAFYDYLKGPQASAIFKRYGFT.............................................. 255
11 -24.000[G] COG1653 ABC-type sugar transport system, periplasmic component  ali follow..  14  6IHKVSICIALTLTFSANAMAVTEIPFWHSMEGELKEVDSIADRFNQSQDYKIVPVYKGNYEQSLAAGIAAFRSGKAPAILQVYEVGTATMMASKAIKPVYQVFKDANIDFDESV-LSQPFNSSTPVLYYNKEAFKKPPKTWQELAADTAK-GQPIASRNNGFDGTDAVLEFNKPLQVKHIQLLSDMKKGDFTYFGRKDESTSKFYNGDCAITTASSGSLASIRHYAKFNFGVGMMPPQNAIIGGASLWVMDGKETYKGVAEFLQYLVKPEIAAEWHQKTGYLPITTAAYELT................................... 359
12 -12.300[P] COG3221 ABC-type phosphate/phosphonate transport system, periplasmic component  ali follow..  11  11AAGLSALALASCSGKSDAPAAFSILSTESTQNMESYWTPILKDMEKQTGLKVKPFFSSNYSSLIVAMGAKQ----TDLGWFSNQSGLEAVRRSNGEVFARTFDPSGTDGYKS-------------VIIVPAD---SKIQSVQDLLKCDKSLDFGIGDKKSTSGTLAPMTYVFIPANKKPETCFKTV------ISANHQANLFAVANGKLDASTNNSTAIGLSKARGETDKIRVIWESP----LPEDPLVWRKDIDPVVKEKLRQFFLT........................................................... 256
13 -10.600[P] COG4521 ABC-type taurine transport system, periplasmic component  ali follow..  15  2AISSRNTLLAALAFIAFQAQAVNVTVAYQTSAEPAKVAQADNTFAKESGATVDWRKFDSGASIVRALASGD----VQIGNLGSSPLAVAASQQVPIEVFLLASKLG----------------NSEALVVKKTI-----SKPEDL-----IGKIAVP---FISTTHYSLLAALKHWG---------IKPGQVEIVNQPPAIIAAWQRGDIDGAYVW--APAVNALEKDGKVLTDSEQVGQWGAPTLDVWVVRKEKHPEVVKAFSK............................................................... 226
14 -9.310[E] COG2113 ABC-type proline/glycine betaine transport systems, periplasmic components  ali follow..  8  9TAGLLMTIGVAAAAEPESCKTVRFSDVG---TDITSTTAVASTILEALGYAPQSKL-LSIPVTYASMKNKDIDVYLGDWQPSMEADRKPFLEDKSIEVIGPNLTG-----------------AKYTFAVPKYVADAGVKDISDLQKFPDKFGRKIYGIEPGNNGNRMILDMINKGD---------FGLTGWELVESSEQGMRATKDDQWIVFLGWAPHPMNTRY-----QIDYLSGADAYFGPNYGGADIYTNIRAGYAQE------CPNVARFVTNLRFTLEMENEIMNGILNDGNDPKDAAA---DWLKAHPEAV-APWLEGVTT 296
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.