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Query: [OC] COG4232 Thiol:disulfide interchange protein, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAQRIFTLILLLCSTSVFAGLFDAPGRSQFVPADQAFAFDFQQNQHDLNLTWQIKDGYYLYRKQIRITPEHAKIADVQLPQGVWHEDEFYGKSEIYRDRLTLPVTINQASAGATLTVTYQGCADAGFCYPPETKTVPLSEVVANNAAPQPVSVPQQEQPTAQLPFSALWALLIGIGIAFTPCVLPMYPLISGIVLGGKQRLSTARALLLTFIYVQGMALTYTALGLVVAAAGLQFQAALQHPYVLIGLAIVFTLLAMSMFGLFTLQLPSSLQTRLTLMSNRQQGGSPGGVFVMGAIAGLICSPCTTAPLSAILLYIAQSGNMWLGGGTLYLYALGMGLPLMLITVFGNRLLPKSGPWMEQVKTAFGFVILALPVFLLERVIGDVWGLRLWSALGVAFFGWAFITSLQAKRGWMRIVQIILLAAALVSVRPLQDWAFGATHTAQTQTHLNFTQIKTVDELNQALVEAKGKPVMLDLYADWCVACKEFEKYTFSDPQVQKALADTVLLQANVTANDAQDVALLKHLNVLGLPTILFFDGQGQEHPQARVTGFMDAETFSAHLRDRQPLast
1 -155.000[OC] COG4232 Thiol:disulfide interchange protein  ali  100  1MAQRIFTLILLLCSTSVFAGLFDAPGRSQFVPADQAFAFDFQQNQHDLNLTWQIKDGYYLYRKQIRITPEHAKIADVQLPQGVWHEDEFYGKSEIYRDRLTLPVTINQASAGATLTVTYQGCADAGFCYPPETKTVPLSEVVANNAAPQPVSVPQQEQPTAQLPFSALWALLIGIGIAFTPCVLPMYPLISGIVLGGKQRLSTARALLLTFIYVQGMALTYTALGLVVAAAGLQFQAALQHPYVLIGLAIVFTLLAMSMFGLFTLQLPSSLQTRLTLMSNRQQGGSPGGVFVMGAIAGLICSPCTTAPLSAILLYIAQSGNMWLGGGTLYLYALGMGLPLMLITVFGNRLLPKSGPWMEQVKTAFGFVILALPVFLLERVIGDVWGLRLWSALGVAFFGWAFITSLQAKRGWMRIVQIILLAAALVSVRPLQDWAFGATHTAQTQTHLNFTQIKTVDELNQALVEAKGKPVMLDLYADWCVACKEFEKYTFSDPQVQKALADTVLLQANVTANDAQDVALLKHLNVLGLPTILFFDGQGQEHPQARVTGFMDAETFSAHLRDRQP 565
2 -47.600[O] COG0785 Cytochrome c biogenesis protein  ali follow..  20  1..................................................................................................................................................................MDVGLVTAFLGGTLALLSPCAALLLPAFFASSVGAG-----PRMILHGVVFYAGLLVLLVPLGLGAGILGELFITQRQT--IIVVSSIVLIILGFVQIFGGGFDFGKALPGL-DRLQSKATVTSGLGKSFLLGMTSSIAGFCSGPILGAVLTLAATSGNSITSALILSAYGAGMVLPLMAIAALWAKLGQRGQQMWHIVSVISGALIIAVGILFW............................................................................................................................................................................................ 219
3 -28.100[O] COG2143 Thioredoxin-related protein  ali follow..  14  4.....................................................................................................................................................................................................................................................................................................................................................................LSYVSKKFLSVLLLISLFLSACKSNNKDK------------------------------------LDENLLSSGSQSSKELNDERDNIDKKSYAGLEDVFS-DNKSISPNDKYMLLVFGRNGCSYCERFKKDLKNVKELRDYIEHFSAYYVNISYSKESTEELAQIYAVQSTPTIVLSDKTGKTI--YELPGYMPSTQFLAVLEFIG. 188
4 -24.600[S] COG2836 Uncharacterized conserved protein  ali follow..  15  1..................................................................................................................................................................MSPDYLGAWVVGLLGAG--CLGMCGGISALLTLDPSK-----SSPALLLYYNLGRLLSYALIGGIVGGITASLTELIDLVWLRIFAAVLMIVLGLYIGRWWEKVGQKIWRWISPLGKTLLPLKKQWHALPFGLVWGWL--PC--GLVYSMLTWSAVAGSFSQGALIMLSFGFGT-LPAMLASGWGANKLMHW---SHLFRQCAAILVIGYGLFTAYD.......................................................................................................................................................................................... 215
5 -23.100[O] KOG0910 Thioredoxin-like protein  ali follow..  21  89.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................STVLESAQPVLVEFVATWCGPCKLIYPAM--EALSQEYGDKLTIVKIDH----DANPKLIAEFKVYGLPHFILF-KDGKEVPGSRREGAITKAKLKEYIDGL.. 183
6 -19.300[AD] KOG3414 Component of the U4/U6.U5 snRNP/mitosis protein DIM1  ali follow..  15  7...................................................................................................................................................................................................................................................................................................................................................................................................................................................................HLHSGWAVDQSILAEEERLVVIRFGHDWDETCMQMDEVLASVAETIKNFAVIYLVDIT------EVPDFNTMYELYDPSTVMFF-FRNKHIM--IDLGTGNNNKINWALKDKQE 111
7 -17.900[S] KOG3425 Uncharacterized conserved protein  ali follow..  19  2.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................ENLIKLYENQRSPIYIYFYGEWCPDCVAAEE-TIMSAFRNHAPADCMILVVDVGSRGKDNMFRKPPYSVEGIPTLIRWK-GVERLDGDQLLKSSLLELFFEETDPKK. 117
8 -15.200[S] KOG2640 Thioredoxin  ali follow..  12  161.....................................................................................................................................................................................................................................................................................................................................................................................................................................................EERNITGLENFTLKILNMSQDLMDFLNPNGSDCTLVLFYTPWCRFSASLAPH----NSLPRAFPALHFLALDASQHS----SLSTRFGTVAVPNILLFQGAKPMARFNH--TDRTLETLKIFIFN... 276
9 -14.300[O] KOG0907 Thioredoxin  ali follow..  17  182..........................................................................................................................................................................................................................................................................................................................................................................................................................................................DNHSAVVQLHGRPDVEKLIDENRTGGKLIVLDVGLKHCGPCVKVYPTV---LKLSRSMSEVVFARMNGDE-NDSCMEFLKDMNVIEVPTFLFI-RDGEIRG--RYVG-SGKGELIGEILR... 294
10 -14.000[O] KOG0908 Thioredoxin-like protein  ali follow..  20  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................................MSVRVINDESHFQAELAQAGIQLVVVDFTASWCGPCKRIAPIF---ETFPTKYPKAIFLKVDV----DKCQDTAAGQGVSAMPTFIFY-RNRTKID--RVQG-ADVNGLEAKIQE... 104
11 -13.200[R] COG2215 ABC-type uncharacterized transport system, permease component  ali follow..  12  74..............................................................................................................................................................NPWQLWSLIGLSFTYGVFHAAGP------AVISSYMIANETELKRGVLLSFLSSILQGVVAILLIGAVYLVLRGSSISMTNATRALEIASYALIAAFGGWLV-----------AHAPDPALLKGDRFALSEAWSAIVAVGLR--PCSGALI--VLSFALLNGLYLGGVLSVFAMSIGTAITVSILATMAVTA-SAAARISNGIEIAGALLVLLLGLVLLGAALQS...................................................................................................................................................................................... 344
12 -12.800[R] KOG2501 Thioredoxin, nucleoredoxin and related proteins  ali follow..  15  2......................................................................................................................................................................................................................................................................................................................................................................................................................................................................STNVMQVLVSKLVGKTIGLYFGAHWCPPFRSF------TSQLVDVYNEVILISTDIPYEDRTRQDLCRIFNVKLIPALVIIGPEEKTVTT..................... 112
13 -12.800[S] COG4243 Predicted membrane protein  ali follow..  15  7...................................................................................................................................................................................TPWIHKWSRLIIAAIAGFG---------ALNTGYLTIEKLTGGSPACVAQAGAKGCTDVLSSPW------ATILGQPLALFGFYTSMLVLALAPVVWKGGDNNSRKQLENVTWWLLLVGAIAMSVFSGYLMYLLAFE-------IKALCLYCI----------------------------SSALFSLSLLVLTILGRSWEDIGQILFTALIVGMVTLIGTLGVYAGINK-------------PDVTSSNIPPGQVAPFVPKTNPNPEFGWEINSTSGEAEIALAQHLVKVGAKEYVAYWCPHCHDQKLL--EAYQIISDNIKVECAEDSPKGQ----PELCRAAKIQGFPTWIINGQ--------TYSGVQNLSELAKITGYTGP 320
14 -12.300[O] KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit)  ali follow..  26  443.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................EIVLDESKDVLLEIYAPWCGHCQSFEPIYNKLGKYLKGIDSLVVAKMDGTSN------EHPRAKADGFPTILFFPGGNKSFDPIAVDVDRTVVELYKFLKK... 537
15 -12.100[R] KOG4277 Uncharacterized conserved protein, contains thioredoxin domain  ali follow..  17  1..................................................................................................................................................................................................................................................................................................................................................................................................................................MQKYFLLPLLSLSVLLFVYDTEATNPPTAVLDLSDKFLD-------VKDEGMWFVEFYAPWCAHCKRLHP-VWDQHTLSDSNLPIRVGKLDCTRFP----AVANKLSIQGYPTILFFRNG----HVIDYRGGREKEALVSFAKR... 130
16 -12.100[OC] KOG1672 ATP binding protein  ali follow..  14  53.....................................................................................................................................................................................................................................................................................................................................................................................................................................................EVEKRESFKRQGHGEYREVSEGDFLGEVTRSEKVICHFYHKEFYRCKIMDKHL---KTLAPRHVDTKFIKVDAENAP----FFVTKLAIKTLPCVVLF-SKGVAMD--RLVGFFTTNKLENVLLK... 175
17 -12.000[OC] COG0526 Thiol-disulfide isomerase and thioredoxins  ali follow..  25  367.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................DIVMDETKDVLVEFYAPWCGHCKNLAPTYEKLAEEYSDDSNVVVAKIDATEND-------ISVSISGFPTIMFF-KANDKVNPVRYEGDRTLEDLSAFIDK... 459
18 -11.800[O] KOG0191 Thioredoxin/protein disulfide isomerase  ali follow..  17  33.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................NTIRASKKGALIEFYATWCGHCKSLAPVYEELGALFEDHNDVLIGKIDADTH----SDVADKYHITGFPTLIWFPPDGSEPVQYS--NARDVDSLTQFVSE... 127
19 -11.500[O] COG3118 Thioredoxin domain-containing protein  ali follow..  18  2............................................................................................................................................................................................................................................................................................................................................................................................................................................................SDTPYIFDVTGANFEQLVIENSFHKPVLVDFWADWCAPCKALMPLL--AQIAESYQGELLLAKVNC----DVEQDIVMRFGIRSLPTVVLF-KDGQPVDG--FAGAQPESQIRALLEPHVK 113
20 -10.500[S] COG5486 Predicted metal-binding integral membrane protein  ali follow..  16  82...................................................................................................................................................................IAAFLAVWTVMMAAMMLPAAAPMIFMFAAAQARRGQQVAVP-----TWIFVAGYMLVWAAAGLLVYVLVQSEFATSLDPPQRSKWAPLALGVTLGVAGLYQFT--TLKHICLSHCRSPLARDGRVGALEMGLRHGL----CFGC-----------------WALFAVLVAAGVMSLAWMLLLTLIVFVEKLMQRGRRFEGALGIALVVLGIIVS............................................................................................................................................................................................ 277
21 -10.100[U] COG2095 Multiple antibiotic transporter  ali follow..  14  12..............................................................................................................................................................................FFLGLVAAVNPVMPVFVS-LTGHMTLEEKNKTAATANIAVAIILIIALLAGMLLDLFSISLDS------FRVAGGLLLLSIAFSM-------MSGKLGEDKQNKQEKSEYISREQIAVVPLAMPLMAGP---GAISSTIVYGSRYPNMLDTLGIILTVVAFSFCSWLLFAPYIVRLLGQTG--INVITRIMGLILGALGIEFI............................................................................................................................................................................................ 200
22 -9.570[E] COG1280 Putative threonine efflux protein  ali follow..  16  5.....................................................................................................................................................................LLGLFIPTFFFVSITPGMNMTLALTLGMSVGYRRTLWMMVGELLGVA----LVAVSAVVGIAAVMLRYPDIFTL----FKIVGASYLVYLGVQMW--------SRGKLAINIEQENTYQGSDWGLLVQGFVTAIA-NPKGWAFMVSLL-FIDQSLSLAPQLTVLVAIILLSEFISMSLYATGGKGL-SQAHHVRLLNRIAGSLMAGVGIWLY............................................................................................................................................................................................ 204
23 -9.520[T] KOG3170 Conserved phosducin-like protein  ali follow..  12  83......................................................................................................................................................................................................................................................................................................................................................................................................................................................KAIKLKNKFGEVLEISGKYYVQEVTKASEGLWVILHLCKRGIPLCALINQHL---SGLARKFPDVKFIKANSTT-------CIPNYPDRNLPMVFVYLEGDIKAQLIGPLVFGGMNLTRDELGWK.. 197
24 -9.260[R] COG3054 Predicted transcriptional regulator  ali follow..  7  2..........................................................................................................................................................................................................................................................................................................................................................................................................................TLRKILAMSCLLLPIMACAHNLEVNQRVPPVGIADRGELTLNKDEFSYKNWNSAQLAGKVRVLLHIAGRTSAKEKNATLIEAIKSAKLPHDRYQTTTIVNTDDADSNGVARNAWQLKEGSAVIVLDKDGRVQ--WVKDGALTQQEVQQVVDLLH. 180
25 -9.250[R] COG0730 Predicted permeases  ali follow..  14  15.....................................................................................................................................................................ISLGLLGGGGSVLALPVLVYVMGIAPKNAIAMTLVIVGTVSLLGSISHWR-TAYIFGGATMLGAFFGARLATLPFITDNIQMLLFALLMLVASIIMIQRSMGTKTTHDELPYPPPVCKHGIIVGGLLVGVGGGFAIIPALV--IAGFLGYLGH-ITLDWSLIFSFILAASGGT---LVGAYLTQFVPA-----TQLQKSFGYFLLAVAAFVL............................................................................................................................................................................................ 253
26 -9.110[S] COG2119 Predicted membrane protein  ali follow..  15  20.........................................................................................................................................................................................LAISITTVALAEIGDKTQLLSLLLASRYIAAIFLATLANHALAAWLGVVVADYLSPDILKWVLVVSFLAMAGWIL--------------IPDKLDGEESISTRGPFVASFIAFFMAEIGDKTQIATSILGAQYADAVIVGTTLGMLLANVPV---VLIGKLSADKMP-----LGLIRKVTAGLFLLMALATA............................................................................................................................................................................................ 198
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 0 9 8   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Jaroszewski L, Li W, Godzik A. A segment alignment approach to protein comparison. Bioinformatics. 2003 Apr 12;19(6):742-9.