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Query: [S] COG4344 Uncharacterized protein conserved in archaea, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSEYEKEIDELINDYDMLRVLKHFTIAHVDYAKNITRYTEIPQMRVREYLKRLKDLGLLDYYTNTSIKRTEAKLKKSAEVHKHHTYYQINKKAEAVLKEITPKLYVHHLKSADLQMLCSRKERKENPEACSSLLRMGLIDKCYDLTDLGREVFDTARRMQILHCEDRNLast
1 -82.700[S] COG4344 Uncharacterized protein conserved in archaea  ali  100  1MSEYEKEIDELINDYDMLRVLKHFTIAHVDYAKNITRYTEIPQMRVREYLKRLKDLGLLDYYTNTSIKRTEAKLKKSAEVHKHHTYYQINKKAEAVLKEITPKLYVHHLKSADLQMLCSRKERKENPEACSSLLRMGLIDKCYDLTDLGREVFDTARRMQILHCEDRN 168
2 -39.400[KG] COG1349 Transcriptional regulators of sugar metabolism  ali follow..  9  1..........MKPRQRQAAILEHLQKQGKCSVEELAQYFDTTGTTIRKDLVILENAGTVIRTYGGVVLNKE----------ESDPPIDHKTLINTHKKALIAAAAVKYIHDGDSIILDAGSTVLQMVPLLSRFSNITVMTNSLHIVNALSEEQTILMPGGTFRKKSAS 151
3 -23.600[S] COG3388 Uncharacterized protein conserved in archaea  ali follow..  15  4YSIFREIINDMDTLKRHISVINVLLREQPIGIIKLSQETGIPEHKIRYSLRILEQENIISPSREGALTPDFIEHKEQIIADAEKVLEEATKIAEDVRKMLEKK................................................................. 107
4 -17.300[K] COG2345 Predicted transcriptional regulator  ali follow..  11  3.DVVKGNDAHTGDGDTRRKILLILLERAPVIASDIAEQLQLSTVGVRRHLDNLVEENLAEA------ANPRQNPYEPKMRGRPAKTYRLTDKGRSIFGHEYDSLAAAALAT......................................................... 106
5 -17.200[K] COG4190 Predicted transcriptional regulator  ali follow..  16  66...........TLTPRVLELIEAIRQEEPASINETARVVDRDVKNVHEELSRLAHLGIIFFEEDG....................................................................................................... 119
6 -16.500[K] COG4742 Predicted transcriptional regulator  ali follow..  18  1MQS--ELIDVVFRSQKRRDLLLLLGE-EPRTMEDIKVLLDVSPTAILPQIKRLTDSNLVIQKNGS---------------------YELTDMGEQVFKKA.................................................................... 76
7 -16.400[K] COG1777 Predicted transcriptional regulators  ali follow..  15  1MIDDIDNFIAAIENSTRREIIRMLTQFERSYALELSRSIGLSQQAILKQLEMLERANLVTSIGFV....................................................................................................... 65
8 -16.100[K] COG3355 Predicted transcriptional regulator  ali follow..  14  25............LSKSDVEVLHILLQNGKMTTDDLSQKLNVTKASISKALNNLLDKGLIQR........................................................................................................... 73
9 -16.100[S] COG3373 Uncharacterized protein conserved in archaea  ali follow..  15  1MEPIGNILRSLNRSELRRKVLFYLLSIYPYYLSEISRAVKSDPSNVKGCLESLIGLGLVIVEQSK----------------NGFKYFKINPEIVEEVRNMKNM................................................................. 101
10 -14.900[KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon  ali follow..  14  1............MKMKTLFLLIKLAKMGAITMRELSRELDVSPQTVLRWLEELKEQGYIHK-----------------RESRKGTLVELTEKGINLLEKL.................................................................... 77
11 -14.600[K] COG5625 Predicted transcription regulator containing HTH domain  ali follow..  18  7LKKLEDLLKAIGLKKNEIRIYRLLEKRRGMRIREIQRELGISERSVRTHVLNLYRRGLLKR........................................................................................................... 68
12 -14.600[K] COG4738 Predicted transcriptional regulator  ali follow..  12  23.YEMVELLRRLNINRPVALTLACLSKGDEISSQRIEMVSGLRQPEVSIAMRYLRENEWVDMREEKKNHGKGRPVK----------LYKLTVQMETIIDTIEENVIAES............................................................ 119
13 -14.300[S] COG4519 Uncharacterized protein conserved in bacteria  ali follow..  10  1MELSPV--------ARRLYLALLVESLERPNVPKLIEKTGWPRRTIQDVIKAMPGIGIELNFVQDG...................................................................................................... 59
14 -14.000[K] COG1522 Transcriptional regulators  ali follow..  9  1.......MSKVELDKIDRKILEVLQSNGRLTNLEVAERVNLSPSPCLRRIRRLEESGVIRQ........................................................................................................... 54
15 -13.500[K] COG1846 Transcriptional regulators  ali follow..  8  29.STPRTFGRAGALTPSEIHTIDAIGTDEGLLMKELAERLGVTKGAVSQLVDRLEAKALVRRTAH--------------PKVSRGIQVVLTDKGREAYRAH.................................................................... 113
16 -13.200[S] COG3398 Uncharacterized protein conserved in archaea  ali follow..  19  172YGEEEKKVVSALQNATNQRIISEIQNGKCNTNLALAREIGVSRATISWYVKNLKETGLIDETRSG-----------------RSIIYSINPSYEPLIEK..................................................................... 253
17 -12.900[K] COG1497 Predicted transcriptional regulator  ali follow..  17  5.........RKKGELTRFQILSEIMRQPYVRQKDIADKLGVTVQAVSENIKSLIAEGLVES-------------------GSGRSHYKITRRGAEKIKEAAMD................................................................. 80
18 -12.700[K] COG1654 Biotin operon repressor  ali follow..  7  1..........MKDTTVPLTLISLLADGEFHSGEQLGERLGMSRAAINKHIQTLRDWGVVFTVPG........................................................................................................ 55
19 -12.400[S] COG2469 Uncharacterized conserved protein  ali follow..  15  186.NFIEKSKPKEKLSEVEEQILTMVYTGVDS--VSVESILGVTTEELNKMYDRLVNLGLARVV-------------------KIRKEIELTPRGVALVSEIMKKAA............................................................... 268
20 -12.400[J] COG4901 Ribosomal protein S25  ali follow..  16  44..........VLDEKVFQAIAKEVQNMRVITPYEIASKYGIKMSVAFKVLRNLKERGDLVLVAKG....................................................................................................... 98
21 -11.800[K] COG3432 Predicted transcriptional regulator  ali follow..  19  42..................DILRNCE--PKCGITRVIYGAGINYVVAQKYLDQLVKVGALNIKTEN-----------------DRKIYEITEKGKLLRTHI.................................................................... 104
22 -11.700[K] COG1378 Predicted transcriptional regulators  ali follow..  17  23MDEIIEVLKRLGFRDYEARVYATLATRGEATASEIHRVSGVPRNKVYEVLRSLEDRGMIETIKSS----------------------------PAVFRAIDPESVLEEYKEQLVSAVDTAIRSIRESEDFSTLHPVWCVRGLAGIKNRAKAMLQRSEE.......... 152
23 -11.500[K] COG0640 Predicted transcriptional regulators  ali follow..  19  1...............................MNEITMQTQADQPKVSSNLAILSEARLVDSIQMG-----------------REKIYRIAPEKFEDMVDWLDSIL............................................................... 57
24 -11.300[K] COG1695 Predicted transcriptional regulators  ali follow..  10  1............MDRYAIKALVLLSKTLYQMSKEISTGVQVSHGTLMPMIRKLLQERYIDFETRG-----------------REKVYHLTERGSRFVESLGKI................................................................. 77
25 -11.200[K] COG5631 Predicted transcription regulator, contains HTH domain (MarR family)  ali follow..  9  69MVRCMAAAGLPGLSPIEILILHSIHRDREKKLADICLALDIDTHIATYAIRKLEKAGLLTT-----------------GKAAKEKTVKITAKGAEACAHYAQVDSTANARPSEETLSELAALLRFMSGAFNQATR................................. 194
26 -10.800[K] COG1675 Transcription initiation factor IIE, alpha subunit  ali follow..  18  1MKAETTTGVEELLNGEVGLILFSLGIEGEFTDDQLSLELGIEINEIRKALFALYEIGLAD............................................................................................................ 67
27 -10.700[J] KOG1767 40S ribosomal protein S25  ali follow..  10  42..........LFDQATYDKLLTEAPKFKLITPSILSDRMRINGSLARRAIRELMAKGVIRMVAAH....................................................................................................... 96
28 -10.700[K] COG4189 Predicted transcriptional regulator  ali follow..  22  10.AEKEFDVLKAAASLIRVQILKLLHEANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLR............................................................................................................ 68
29 -10.400[K] COG1321 Mn-dependent transcriptional regulator  ali follow..  15  1...MVLMHTDRIEEYLETILYLITKNQGPAKTKQIAEELNVSSPSVTEMIKKLHSMGFVEYKPYQGVELTEKGAEEAVRIKRKHQVLE................................................................................ 85
30 -10.400[K] KOG2593 Transcription initiation factor IIE, alpha subunit  ali follow..  10  16KNNNQKKSAKNGSGGIAVLVLDALTRRQWVREEDLAKELKLNTKQLRTILRYFEEQQFIMRVHRKEKSSATTNGRGEDKVKVHMYSYKLHRMKKEFKDVLEDKDNVQ............................................................. 136
31 -10.400[K] COG2378 Predicted transcriptional regulator  ali follow..  11  10VSPYHMEMYNMRKASRLFEIIQILRARRPVTAQTIADMLEVTARSVYRDIAALQTMRVIEGERGVGYI.................................................................................................... 79
32 -10.300[S] COG2512 Uncharacterized membrane-associated protein/domain  ali follow..  16  246............LSPELCEVLDIIRGHGRITQKDLRSKLDYSEVKVSLMLSELEKRGLIRKLRNG....................................................................................................... 299
33 -10.300[K] COG3327 Phenylacetic acid-responsive transcriptional repressor  ali follow..  15  1MSKLDTFIQHAVNAVSGTSLISSLGEIWLGSLAALLEGLGFGERFVRTALFRLNKEGWLDVSRIG-----------------RRSFYSLSDKGLRLTRRAESK................................................................. 97
34 -10.300[K] COG1414 Transcriptional regulator  ali follow..  10  1MREPTLETDDAPALDKGLDILELLASVDGGLQAEIAKHLDRSPNEFYRMLDRLVKRGYVTKLDGDRYSLTLKLFGLAQLHAPVRRLASFAT--RELADRSKQANQLAVFDRGSVVVIAQQEAPDYWGISIRVGSHISLFDTGSGHVLL.................... 153
35 -9.990[O] COG5187 26S proteasome regulatory complex component, contains PCI domain  ali follow..  8  303...LVAHYRYYVREMRRRAYAQLLESYRALSIDSMAASFGVSVDYIDRDLASFIPDNKLN----CVIDRVNGVVFTNRPDEKNRQYQEVVKQGDVLLNKL.................................................................... 395
36 -9.850[K] COG1420 Transcriptional regulator of heat shock gene  ali follow..  12  1...........MLTERQLLIFRFTWTIQPVGSKNLLKELPYSSATIRNEMGVLEEYGFIEKTHSSS...................................................................................................... 62
37 -9.680[S] COG4860 Uncharacterized protein conserved in archaea  ali follow..  11  12.GELVSIFHAA-DSEVKRKLLLDLST-GWITLPVIEQKYG---KEGRRALLYLDKIKMIE............................................................................................................ 65
38 -9.670[K] COG1510 Predicted transcriptional regulators  ali follow..  7  17IEKIAENMHTFGMPSTVGRVLGII-NRKPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVF---------------EKGVRKDLYDVEQDYYQTFISLFAANWTKVVSKNKVLYKKLNRELSDLLQR....................................... 131
39 -9.460[K] COG2186 Transcriptional regulators  ali follow..  9  1...MNGQAKIAEPRRLYQQIADQIREL---AERELAQKLGVSRPSLREALIALEIDNTVEIRMGSGVYVSTEALQTTHHTKSLGDSPSELMQARAALEGATIVLAANRMTDETIAAL................................................... 124
40 -9.430[O] KOG0687 26S proteasome regulatory complex, subunit RPN7/PSMD6  ali follow..  10  288...FAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLH----CKIDKVNEIVETNRPDSKNWQYQETIKKGDLLLNRV.................................................................... 380
41 -9.380[K] COG2188 Transcriptional regulators  ali follow..  10  38................................NELVASLGVSRMTVHRALRELTAAGFLIRLQGVGTFIAPPRPQSTLIEINNIA--EIVERGNRHRSEVLVLETIM............................................................. 111
42 -9.290[S] COG4197 Uncharacterized protein conserved in bacteria, prophage-related  ali follow..  11  1.................MTLKEFIKSLRVGDAKKFAARLGVSPSYLSQMASGRTAISPIESATEGQVSRAE................................................................................................. 59
43 -9.130[K] COG1733 Predicted transcriptional regulators  ali follow..  12  17.........EVLCTRWTMVLMREL--AGSTRFNDLRRGVKMSPTLLSQRLKELELAGIVER--------------KEVPGEKGIFDYRLTEAGRDLRPVVEA.................................................................. 95
44 -9.110[OT] KOG0686 COP9 signalosome, subunit CSN1  ali follow..  8  367...LAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLIS----ARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRA.................................................................... 459
45 -9.090[K] COG1725 Predicted transcriptional regulators  ali follow..  9  15...........ISDWMKKQMITGEWKGEDKSVREMGVKLAVNPNTVSRAYQELERAGYIYAKRG........................................................................................................ 69
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;