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Query: [R] COG4589 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPDSLQTLYYCLGGIFSVLLLATIIIFVLKKCRPQRDWLELQQRINSWWVIICLFSLAMLSPKWLALTFFGFISFLSLKEYLTLAPTRRSDSVPLLWMYAAIPLQYVWIGMSWYGMFIIFIPIYVFLFLPARMVLVGDTKGFLHSASIMHWGMMATVFALSHVAYLLTLPGVDAKAGALLVIFLVVATELNDISQYLWGKSLGKIKVTPKVSPNKTLAGLLGGVLTTMLLAAIFGPLLTPMDWLHSLGAGVIIGLSGFCGDVVMSAIKRDFGVKDSGKLLPGHGGILDRLDSLIYTAPLFFHFYHYFYVLast
1 -102.000[R] COG4589 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase  ali  100  1MPDSLQTLYYCLGGIFSVLLLATIIIFVLKKCRPQRDWLELQQRINSWWVIICLFSLAMLSPKWLALTFFGFISFLSLKEYLTLAPTRRSDSVPLLWMYAAIPLQYVWIGMSWYGMFIIFIPIYVFLFLPARMVLVGDTKGFLHSASIMHWGMMATVFALSHVAYLLTLPGVDAKAGALLVIFLVVATELNDISQYLWGKSLGKIKVTPKVSPNKTLAGLLGGVLTTMLLAAIFGPLLTPMDWLHSLGAGVIIGLSGFCGDVVMSAIKRDFGVKDSGKLLPGHGGILDRLDSLIYTAPLFFHFYHYFYV 309
2 -78.700[I] COG0575 CDP-diglyceride synthetase  ali follow..  26  1........................................MKQRIITALILAPLVILGILYPFAWFMLALAVVTLLGFWEWTQFVNQPSRMLAMIPALLVGGISVALIDFQFPAIVLGIGSLWWLVSSGLAITYPRSRPLWEHSSTVRHLFGLFTLLPFFWSVLFLRADTLSDPLYGAKLVLFVCFLVWAADSGAYFVGKSLGKHKMAPAVSPNKTIEGLVGGIVTAMLVGYWVAECFQFSSMPVMLLIILLTVVISVLGDLVESMFKRVSGIKDSSNIIPGHGGILDRIDSLTAAFPVFALLYFLF.. 280
3 -70.000[I] KOG1440 CDP-diacylglycerol synthase  ali follow..  19  38.............................LLVNDRNKYKSFMVRTYSTLWMIGGFVLVVYMGHLYITAMVVVIQIFMAKELFNLLRKAPEDKCLPYIKQLNWHFFFTAMLFVYGRILSAICYLLYIIGFMWFILTLKKKMYKYQFGQYAWTHMILIVVFTQSSFTVANI-----FEGIFWFLLPASLIIINDIFAYIFGFFFGRTPLI-KLSPKKTWEGFIGASVTTIISAFVLANILGRFPWLHALCLGLFASIIAPFGGFFASGFKRAFKIKDFGDSIPGHGGITDRMDCQMVMAVFAYIYLQSFI. 378
4 -19.500[S] KOG4453 Predicted ER membrane protein  ali follow..  14  80................................................................FGVTSIVAFSCLGFWGEIGKRGIFDQKLIRKLVHINIGLVFMLCWPLFSSGIQGALFASLVPGLNIVRMLLLGLGVYHDEGTIKSM-GPLYYVLSITSACIYYWKSSP-------IAIAVICNLCAGDGMADIVGRRFGTEKL--PYNKNKSFAGSIGMATAGFLASVAYMYYFASFGYIEDSGGMILRFLVSIASALVES--------------LPISTDIDDNL-----TISLTSALAGFLLF 307
5 -13.900[I] KOG2468 Dolichol kinase  ali follow..  13  341..........LSLCIYWILLIVVSVSRFYNISRSSKVERILLRKYYHLMAVLMFLPALVLQPKFLDLAFGAALAVFVALEIIRVSSLLLKEISFYFSLLSMGLMQDTHCENQIWRIQPLGEPLHQFMNAFT------------RDSEHLIVSHFSLLLGCALPIWM----SSGFNDRALSPFAGILSLGIGDTMASMVGHKYGVLRW----TGKKTVEGTAAGITSMMAVCFVLVPILASMGYILSQGWWSLL-VAVTATGMLEA--------------------YTAQLDNAFI--PLVFYSLLCL.. 598
6 -11.500[I] COG0170 Dolichol kinase  ali follow..  12  115..............................................................APYAFVEIGCILLACLLAQVLLLRSPCTNLKRKTFHLFAFLVFYKEHRVSFLLAEGLLLFMSLLSSCRYTNSLLRPFFSR-NDKGRTLLSPIYLLSACMYPRLF---------IEDVEYVSALISICFQDSAASIAGKWFGVTE--------KSIQGAIAGVISGTVVYFALYGRID-------------MLPFFIFAGSVEYLVPIN--------------------DNITI--PLFAVLYFQAP. 307
7 -9.150[S] KOG4491 Predicted membrane protein  ali follow..  12  1.................MTDLNDNICKRYIKMITNIVILSLIICISLAFWIISMTASTYYISPWRWLFSVVVPVLIVSNGLKK-------KSLDHSGALGGLVVGFILTIANFSFFTSLLMFFLSSSKLTKWKGEVKKRVQVFCNGAVPTELALLYMIENGPGEIPVDFSKQYSASWMCLSLLAALACSAGDTWASEVGPVLSKEKVPVGTNGGVTVVGLVSSLLGGTFVGIAYFLTQLIFVSAPQWPIIAFGGLAGLLGSIVDSYLQYTGLDESTGMVVNSPTGKVNLFSSVLIALLLPTAAWGFW.. 333
8 -8.910[S] COG1836 Predicted membrane protein  ali follow..  9  2.................................................................IVLALLGVLLLSVYAYKT-------KKLTLSGAISAFVVGALISFGLGFKGLLLLAIFFFTSGFWSRFYQERKENEITAKGSTRDGWQVLANGGFAAICAL--LFSILQDPIYICGFVASLAAANADTWASEVGPLAKRKPVDAGTSGAVSAIGTAAAFAGSFIIV-VVSIFFWWSSSFASHHLLFSLTLAGFLGNLFDTLVERKIHCNGPTEKKYGNNDTVNAICTGTGALFGIVAGLILL.. 262
9 -8.440[P] KOG4505 Na+/H+ antiporter  ali follow..  10  13....................................................................................................................LAYAIIGGFTSLFMLCSLIIKEKLFLGEATMATATGLIFGPYVAKLFVPTSWGNTDYITEELARVLLVVEV--------FAAGAELPRAYMLRHWRSMFVM--LPVMIFGWLVSTGFMYALIPRLSFLESLAIAACITATDPV--LASSIVGKARRVPGHRNMLLAESGCNDGM-----AIPFLYLAIYLI.. 191
10 -7.630[K] KOG3219 Transcription initiation factor TFIID, subunit TAF11  ali follow..  16  97................................................................................................................................................................................................LFSAMSEEQLSRYEVCRRSAPKARIAALMQSITGRSVSENTA------------IAMAGIAKVF--VGEVVEEALDVCEMWGETPPLQPKH.......................... 174
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.