| | | | | | . 10 . 20 . 30 . 40 . 50 . 60 . 70 . 80 . 90 . 100 . 110 . 120 . 130 . 140 . 150 . 160 . 170 . 180 . 190 . 200 . 210 . 220 . 230 . 240 . 250 . 260 . 270 . 280 . 290 . 300 . 310 . 320 . 330 . 340 . 350 . 360 . 370 . 380 . 390 . 400 . 410 . 420 . 430 . 440 . 450 . 460 . 470 . 480 . 490 . 500 . 510 . 520 . 530 . 540 . 550 . 560 . 570 . 580 . 590 . 600 . 610 . 620 . 630 . 640 . 650 . 660 . 670 . 680 . 690 . 700 . 710 . 720 . 730 . 740 . 750 . 760 . 770 . 780 . 790 . 800 . 810 . 820 . 830 . 840 . 850 . 860 . 870 . 880 . 890 . 900 . 910 . 920 . 930 . 940 . 950 . 960 . 970 . 980 . 990 . 1000 . 1010 . 1020 . 1030 . 1040 . 1050 . 1060 . 1070 . 1080 . 1090 . 1100 . 1110 . 1120 . 1130 . 1140 . 1150 . 1160 . 1170 . 1180 . 1190 . 1200 . 1210 . 1220 . 1230 . 1240 . 1250 . 1260 . 1270 . 1280 . 1290 . 1300 . 1310 . |
| # |
Score |
Template |
Links and tools | %id | First |
VNRWFAQHPDFVLGTHALTSGPFGETYTCLAPDGEDLDAALSAAVHLFPEGRYDGEPTQIDLDLEDATDDSPRDLPAGRHVREGSFFVDNARGLMQVIDGEPVAVKVRKGRNADGIPEKHVRIIRKLISVRDAVRVVLKAQELDQPWKDLQVRLRIAWSSFVRDFGPINHTTVSITEDPETGKTRESHRRPNLQPFADDPDCWLVASIEDYDLENDTARPGPIFTDRVISPPAPPVITSAADALAVVLNERGHVDRDHIAELLHRDPEDVVTELGSAIFRDPADGSWQMADAYLSGHVREKLKVADAAAGLDPAYERNVSALTAVQPVDLRPSDITARLGAPWIPAGDVVAFVKEMMGTDIRIHHMPELASWTVEARQLSYLAAGTSEWGTDRRHAGELLSDALNSRVPQIFDTIRDGDSEKRVLNVVDTEAAKEKLHKIKQAFQRWIWSDPDRTDRLARVYNDRFNNIAPRKFNGDHLKLPGASGAFVLYGHQKRGIWRIISAGSTYLAHAVGAGKTMTMAASIMEQRRLGLVAKAMQVVPGHCLAQAAREFLALYPTARILVADETNFSKDKRARFLSRAATATWDAIIITHSAFRFIGVPAAFEQQMIHDELELYETLLLKVEDEDRVSRKRLERLKEGLQERLEALSTRKDDLLTIAEIGVDQIIVDEAQEFRKLSFATNMSTLKGVDPNGSQRAWDLYVKSRFIETINPGRALVLASGTPITNTLGEMFSVQRLMGHPALMERGLHEFDAWASTFGDTTTELELQPSRKYKPVSRFASFVNVPELIAMFRSFADVVMPADLREYVKVPAISTGRRQIVTSKPTQAFKHYQMVLAERIKAIEEREGPPQPGDDILLSVITDGRHAAIDLRLVDADNDNEADNKLNNLISNAFNIWKATEGSTYLRHDGKSFELTGAAQMIFSDLGTISVEKTRGFSAYRWIRDELIRLGVPASQIAFMQDFKKSEAKQRLFGDVRAGSVRFLIGSSETMGTGVNAQLRLKALHHLDVPWLPSQIEQREGRIVRQGNQHDEVDIFAYATEGSLDATMWQNNERKARFIAAALSGDTSIRRLEDLGEGQANQFAMAKAIASGDQRLMQKAGLEADIARLERLRAAHLDDQHAVRRQIRDAERYVESATRRIAEIGQDIERLVPTSGDAFSMTVMGKVYAERKEAGRALMKEILTQVQLQRQGEKVIASIGGFDLKYGGERFGRDGYRYTTMLMRTGADFEIDLAVTVTPLGAVSRLEHALGDFEGERERNRQRLADARRRLASYQSRDEGRDFAFAGELAEKLRQLAEVDAALATDVDERIAA | Last |
| 1 | -290.000 | [KL] COG4646 DNA methylase |
ali |
100 | 1 | VNRWFAQHPDFVLGTHALTSGPFGETYTCLAPDGEDLDAALSAAVHLFPEGRYDGEPTQIDLDLEDATDDSPRDLPAGRHVREGSFFVDNARGLMQVIDGEPVAVKVRKGRNADGIPEKHVRIIRKLISVRDAVRVVLKAQELDQPWKDLQVRLRIAWSSFVRDFGPINHTTVSITEDPETGKTRESHRRPNLQPFADDPDCWLVASIEDYDLENDTARPGPIFTDRVISPPAPPVITSAADALAVVLNERGHVDRDHIAELLHRDPEDVVTELGSAIFRDPADGSWQMADAYLSGHVREKLKVADAAAGLDPAYERNVSALTAVQPVDLRPSDITARLGAPWIPAGDVVAFVKEMMGTDIRIHHMPELASWTVEARQLSYLAAGTSEWGTDRRHAGELLSDALNSRVPQIFDTIRDGDSEKRVLNVVDTEAAKEKLHKIKQAFQRWIWSDPDRTDRLARVYNDRFNNIAPRKFNGDHLKLPGASGAFVLYGHQKRGIWRIISAGSTYLAHAVGAGKTMTMAASIMEQRRLGLVAKAMQVVPGHCLAQAAREFLALYPTARILVADETNFSKDKRARFLSRAATATWDAIIITHSAFRFIGVPAAFEQQMIHDELELYETLLLKVEDEDRVSRKRLERLKEGLQERLEALSTRKDDLLTIAEIGVDQIIVDEAQEFRKLSFATNMSTLKGVDPNGSQRAWDLYVKSRFIETINPGRALVLASGTPITNTLGEMFSVQRLMGHPALMERGLHEFDAWASTFGDTTTELELQPSRKYKPVSRFASFVNVPELIAMFRSFADVVMPADLREYVKVPAISTGRRQIVTSKPTQAFKHYQMVLAERIKAIEEREGPPQPGDDILLSVITDGRHAAIDLRLVDADNDNEADNKLNNLISNAFNIWKATEGSTYLRHDGKSFELTGAAQMIFSDLGTISVEKTRGFSAYRWIRDELIRLGVPASQIAFMQDFKKSEAKQRLFGDVRAGSVRFLIGSSETMGTGVNAQLRLKALHHLDVPWLPSQIEQREGRIVRQGNQHDEVDIFAYATEGSLDATMWQNNERKARFIAAALSGDTSIRRLEDLGEGQANQFAMAKAIASGDQRLMQKAGLEADIARLERLRAAHLDDQHAVRRQIRDAERYVESATRRIAEIGQDIERLVPTSGDAFSMTVMGKVYAERKEAGRALMKEILTQVQLQRQGEKVIASIGGFDLKYGGERFGRDGYRYTTMLMRTGADFEIDLAVTVTPLGAVSRLEHALGDFEGERERNRQRLADARRRLASYQSRDEGRDFAFAGELAEKLRQLAEVDAALATDVDERIAA |
1315 |
| 2 | -33.600 | [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family |
ali follow.. |
14 | 489 | ........................................................................................................................................................................................................................................................................VEERKMLEEVFSGFIYDERDGAFRVKSEFMTETI-PANQHRITFNCPENLSGQFIYDETIFE-------SFREGSDINYYEADLKVHGLLKGVPLDLLWDCISAKKRFL-KAGQQSKGTRRGKVNSGKLPCILVLDLEKIAP---------------VQIFNEIGFKVLDDLVQKCPLWSLTGISLDQFEALPVNFSMSERLIEIQKQIRGEIEFDFQDVPQQIQLRSYQTEGVHERLRK-NGILADDMGLGKTLQAIIAVTQSKLEKGSGCSLIVCPTSLVYNWKEEFRKFNPEFRTLVIDG---VPSQRRKQLTALA--DRDVAITSYNLLQK--------------------------------------------------------DVELYKSFRFDYVVLDEAHHIKN-------------TTRNAKSVKMIQSDHRLI-----------LTGTPIENSLEELWSLFDFLMPGLLSSY-----DRFVGKYIRTGNYMGNKADNMVALKKKVSPFI---------------RMKEDVLKDLP-----PVSEILYHCHLTESQKELYQSYAASAKQELSRLVKQEGFERIHIHVLAT-KQICCHPAIFAKDAPEPGDSKYDMLMDLLSSLVDS-----------------GHKTVVFSQ--------------YTKMLG-IIKKDLESRGIPFVYLDGSTKNRLDLVNQFNEDPLLVFLISLKAGGTGLNLVGADTVIH-YDMWWNPAVENQATDRVHRIG-QSRSVSSYKLVTLNTIEEKILTLQNRKKSLVKKVINSDDEV--------VSKLTWEEVLELLQ.............................................................................................................................................................................................................................. |
1165 |
| 3 | -33.300 | [B] KOG0389 SNF2 family DNA-dependent ATPase |
ali follow.. |
14 | 283 | ...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LSSGLQLADYQIIGLNWLTQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAALIVVPSSTLDNWEAEISRWCPELVVEKYHGSQDERRRMRGRFAKDGFTGFDVLLTTYHI-----------------------------------------------------VGSTPEERKMFRVCKLDYVIFDEAHMLKN-------------------MTTQRYANLITINARMR----ILLTGTPLQNNLLELISLLCFVMPKFFAK----SIEDIKSLFAKKGKSDGDQDEVSQFQETQIQRAKRIPFVLR--------RLKKDVLKNLPKKL-----SLVEKVPMSSQQKIYYHELVDYYSNNKGEVC--SSSERAGIAIMMEMRRIANHPLLMRHYFTDANLRGFSKRLAN-FQVYQMMNKHEFYDVKIPDNLICDSGKFLYLDTLLPKLKAEGH--LFSQFTMMLVEEYLRIRKFGFCRDGATANVRQDLITDFNGDSIFVFLLSTKAGGVGINLTAADTCV--HDIDFNPYNDKQAEDRCHRMG-QQRPVTIYRLISESTIEEGILMAAEEKLKLEKDITSNEKGEVHEQRCVVKLLTT....................................................................................................................................................................................................................................... |
819 |
| 4 | -29.500 | [L] KOG1002 Nucleotide excision repair protein RAD16 |
ali follow.. |
13 | 136 | ......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IMPLLRYQKEFLAWATKQEQSILADEMGMGKTIQAISLVLARRE--AAGCTLVLCPLVAVSQWLNEIARFTSPGSTKVLV---YHGAKRAKNIKEFM--NYDFVLTTYSTVES--VKTAKQSKQKRKKTSDSSSQQGKEADAGEDKKLKKSKKKTKQTVEKDQLGSDDKEKSLLHSVKWNRIILDEAHYIKE-------------RSNTARAVFALEATYRWA-----------LSGTPLQNRVGELYSLIRFLQIRPYSYYAVRHFCWWNKYVAKPITVYGSFGLGKRAMILLKHKVLKDILLRR---------TKLG----AADLALPPRIITLRRDTLDVKEFDYYESLYKNSQAE--EAGTLMNNYAHIFDLLTRLRQAVDHPYLVVYSNSSGTSTKIEALREEIRFMVERDGSAKAI------------------------------FSQFTSFLD-LINYTLGKCGVSCLVGSMTMAARDTAINKFKEDDCRVFLMSLKAGGVALN----LTVASHMDPWWNPAVERQAQDRIHRIG-QYKPIRVVRFIIENTVEERILRLQKKKELVFEGTVGGSQ--------EAIGKLTEEDMRFLFTT............................................................................................................................................................................................................................. |
833 |
| 5 | -28.500 | [KL] KOG0387 Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain) |
ali follow.. |
15 | 276 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HLFRYQVTCVQWLWQEAGGIIGDEMGLGKTIQIVSFLSSLHHSGKFQKPLIVCPATLMKQWVNEFHTWWAPLRVVVLHATGSGQRASRE-------------------KRQYESDASESEAEESKTSIKLRGASSSFHRYAKNLVESVFTRGHILITTYAGLRIYGD---LILPREWGYCVLDEGHKIRN-------------------PDSEISISCKQIRTVNR----IILSGTPIQNNLTELWNLFDFVFPGRLGTL-----PVFQNQFALPINIGGYANASNVQVQTAYKCACMLRDLISPY------RMKLDVAADLP-----KKSEQVLFCKLTPLQRKAYQDFLQGSDMQKILNGKR-----QMLYGIDILRKICNHPDLVTREYLLHKSGKL-KVIRALLTLWKKQ----------------GHRTLLFSQT-----------QMLDILEIGLKD--LPDVHYCRMDGSTSIALRQDLVDNFNKEYFDVFLLTTRVGGLGVNLTGADRVI--FDPDWNPSTDAQARERAWRLG-QKKDVVVYRLMTAGTIEEKIYHRQIFKQFLTNKILKDPKQRRFFKMTDLHDLFTLGDNKTEGTETGSMFLGSERVLRKDNSSRNGNEAEDIPARDRKKHKIHDKG.................................................................................................................................................................................... |
844 |
| 6 | -20.600 | [R] KOG0354 DEAD-box like helicase |
ali follow.. |
12 | 69 | .....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................INVSFRDYQFNIVQKALFE-NVLVALPTGLGKTFIAAVVMMNYLRWFPKSYIVFMAPTPLVTQQMEACYKITGPKSQTAELSGHVPVTTRNQYYQS------NVFFVT--------------PQTILNDI--------------------------------------KHGICDRTRISC--LVIDEAHRVHLLSLSNKNFRILALSATPGNKLEAIQNVIDSLHISR------------IEIRTENSIDISQYVQKKEVDFFPVDRFSSILEPMLQKLNKGNYYRIQNAKDITSFTVVQAKQAFLAMSGQNFPANQKWDILNTFDALATFAYPLNLLLNHGIRPFYQKLREVEEECF-------VGRSGYKKRIINHENYRPLMDDIEILLRDQSFVGHPKLEHLERIVTEYFEKEQT-------------KDTRIMIFVEIRSSAEEILRFLGKFYPNVRPAIFIGQSAVR----AAGMSQKLQNETVKQFQKGEVNTLI-ATSIGEEGLDIGEVDMIICY-DASASPIRMLQRMGRTGRKRK-----YIYMLLTRGKEEAKWERAKDAYRTLQDNIVSGR....................................................................................................................................................................................................................................................... |
572 |
| 7 | -18.600 | [R] COG4889 Predicted helicase |
ali follow.. |
14 | 6 | ........................................................................................................................................................................................................................................................................................................DAVSALRTLPSQSAQGLAFEKLMVNFIKSDPT------LSTEFDEVHRWVDWPYNGGTMDTGIDLVAYNKDDDAYTAIQCKFYLPTTSLAKGQLDSFFEASGRTFETPEGTRLVISTTDKWSSNAEKMLENQTIPTNRIGLSAIAESPIDWDIAYPGSELTINLQ----------------------LKEPYSPRPHQQTAIEKAIEHDRGKLIMACGTGKTFTALRLSEEVRLNGNKARILFLVPSSLLSQTLKEWTA--DLRPVAVCSDSKVSKAAEDIAAYDLE----------------VPVSTD----------ALIAEKLEHRKRAAGLTV------VFSTYQSLPAVHAAQEAGAE-----FDLVICDEAHR-------TTGITLAGEDPSNFTRIHD--------ASYIKAAKRLYMTATP------------RLFDDSVKGKAAVSSMDD-EAIYGPEFHRLGFGEA---------------KGLLTDYKVVVMTVDEQVAASALTVLGSTPGEE--LTLDMTSAIIGAWNGLAKRSGKEQDTKTGFSSSDAAMERAVAFARDIK-------------TSQQIAESFPRVVNAYTTELEVKNDDVDEHNLNLS---------------------------------------ACQHVDGSMNALERNSRLTWLKASMETKILTNARCLSEGVDVPA-LDSVIFFNPRNSMVDVVQSVGRVMRKGKNYGYIILPVAVPPGV.............................................................................................................................................................................................................................................................................. |
619 |
| 8 | -17.000 | [R] COG1202 Superfamily II helicase, archaea-specific |
ali follow.. |
13 | 216 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ELLPVQVLAIKNGLLKGNLLVVSATASGKTLIGELAGI--PKALEGKKMLFLVPVALANQKYEDFKRRYSKLGLKVAIRVMSRIKTREEPVVVDTGIDADIIVGTYEGVDYLLRSGKKIGN-------------------------------------------------------VGTVVIDEIHMI-----------------DDEERGPRLDGLIARLRKLYPKAQFIGLSAT-VGN---------------------PQELARSLGMK----------------------------------------------------------------------------------------------------LVLYDERPVDLERHLIIARNESEKWRIIAKLCKAEVMRKSSKGFKGQT--------------IVFTYS-----------KRCHELASFLTGKGL---KAKPYHSGLPYKQRKITEMEFQAQMIDVVV-TTAALGAGVDFPASQVIFESLNKWLSVREFHQMLGRAGRPLYHEKGKVYLIVEPGKKYSAQMDETEDEVALKLLTSPIEPVIVEWSDEIEEDNVLAHACVFNRLSVIEEVNSLTLAKKVLEKLEELGMVSIRGDIVRVTPYGRAVSMSFLLPSEGEFIRENLESMDP................................................................................................................................................................ |
669 |
| 9 | -16.700 | [R] COG1203 Predicted helicases |
ali follow.. |
13 | 12 | .......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HSPYEYQKEAMDNLLEGKSLIIRAPTGAGKTEASLIPFIYGLNDYLPPQLIYSLPRTLVESIGERAIKYASFKKL--------------------------RVAIHHGK----ATSSLFEEDIIVTTIDQTAGAY-----------------------SVPLSMPKRWGNIFVGGIASALTVFDEVHTL------------------DPEKGLQTAAAIAMQSAKLGLP-SIIMSAT--------------------LPDVFIERVKERIEKNGGKVEIMDVKNESEIKSRRN----------------------------------------RKVELINRPDEMLTADTVLKEAE-----------NCRKLVVVVNTVERAQ---------------------------------------------------------------------NLYLDLRKKI------DYPIFLLHSRYLEKDRAEKEKSFKNGKGECIFISTQVIEVGMDISSPIILSE------APIDLIQRAGRCARWGGNG-EFHVFGLARDSSNPYAPYELIESTITEIRSKGDFPLDWQTELQLVNNV---LSSHFEFFMDSKFFYQRLG--------ELARAVYEGSKAKVEQNVREIFS..................................................................................................................................................................................... |
434 |
| 10 | -16.500 | [LK] COG1200 RecG-like helicase |
ali follow.. |
16 | 267 | .......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FQPTNAQKRVVSDIEQD-MRLVQGDVGSGKTLVAALAALTAIDNGK--QVALMAPTEILEQHANNFRRWFKPFGIEVG-AGKVKGKSRQAELEKIKTGAVQMVVGTHALFQ---------------------------------------------------------EEVEFSDLAL--VIIDEQHRF------------------GVHQRLMLREK----EKAGFYPHQLIMTATPIPRTLA-------------------------MTVYADLTSIIDELPPGRTPITTVVVSEERRAEIVMRVKN----------------------------------------------------------------ACVNEKRQAYWVCTLIDES---------------------------------------------------EVLEAQAAEAIWEDLTKAL-----PMLNIGLVHGRMKPQEKQDVMMRFKNAELDLLV-ATTVIEVGVDVPNASLMIIENAERLGLSQLHQLRGRVGRGCTASFCVLMYK-VLRDSQDGFVISEKDLEIRVLGTKQTGIAELRVANLMRDRKMIPTVQHYALIQKYPDVAES...................................................................................................................................................................................................................... |
678 |
| 11 | -16.400 | [KL] COG1061 DNA or RNA helicases of superfamily II |
ali follow.. |
13 | 9 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................YDRGTLILHPPPRGKAWMDYATWFRIPAMRYRAVVEALQAEDVFFIDEAKQFYPIDLV-PSLEMEPYPHQSEALAAWKLAGQGVVVLPTAAGKTYLAQLAMQATPR-----TTLIVVPTDLMHQWYAHLVAAFPDAEVGLLGGGSRDKSP---------------VLVA--------------------------------------TYDSAAIHAEALGNQY------------------ALIVFDECHHSKVIAEYAIAPYRLGL------------------------------SATPERTDGKH---------------------ADLNILIGQEVYRKRAEDL----AGKALAEHEIVQIKVKL---------------------------------SQQERERYNNLIQIRNDFLRQSKVSLGSIQGWQMFVQMSARSQSGRRAMLAHREAKEIALGTDSKLRILANLLAKHYPER----------------LIFTA----------DNATVYKISQDL--------LIPAITHQTPVKERHEILTKFREGEYNTLV-ASHVLNEGVDVPAAAIAI--LSGTGSTREYIQRLGRILRKGIQNKQAILYEVIAEDTTSARRRGEDKKANLQVVYGSGKGTTAKAAEQIEINYVVDNSSANNQGNATNGTPQPSPKRRRNNTKKTED........................................................................................................................................................................................................ |
517 |
| 12 | -16.300 | [A] KOG0349 Putative DEAD-box RNA helicase DDX1 |
ali follow.. |
11 | 24 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LPTDIQAESIPLILGGGDVLMAAETGSGKTGAVIQIVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSR-------EVKEWHGCRATKGLMGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDIDKGHVKFSKNGMKNQALFPACVLKNAELKFNFGEEEFKFPPKDGQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVST-LNLSQVRFLVLDEADGLLSNRMHNQIPQVTSDGKRLQVIVCSATFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKID-----------DNLEQYFIQQGGGPDSCVCLHGDRKPHERKQNLERFKKGDVRFLI-CTDVAARGIDIHG-VPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWGCTIWQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQ-KRAAGGGSYKGHVDILAPTVQELAALEKEAQTSFLHLGYLPNQL....................................................................................................................................................................................... |
736 |
| 13 | -16.000 | [L] COG1198 Primosomal protein N` (replication factor Y) - superfamily II helicase |
ali follow.. |
15 | 257 | ....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SRPLELNPEQRQARDAVVSSPPFLLQGITGSGKTEVYLQIIQGALDKG--KTAILLVPESLTPQMTERFIARFGDK--VAILHSGLSNGEKYDEWRKVERGDAQVVVGARSAI------------------------------------------------------------APLKNLGV--MIIDEEHEYKQ-------------DSNPRYHAREVAI----LRAQYNQATLVLGSATP--------------------------SLESRARAGKGVYQHLRLT--------QRANPLATIPEV-----QVIDFRD-----------YIGQNETSNFTPPLLEAIQDRL-----------------VKKEQVVLMLNRRGYSSFVMCR-----------GTVDTCPNDISLTLHMDTKTMNCHYCGFSKDIPKSRSIRYYGTGTQKAYDE-------------LAELFPQARILRM-DVDTTRKKQALLDQFGRGEADILLG-TQMIAKGLDFPNTLVGVLNADTDFRSSELTQRSGRAEKAGQVNPQHYAIRFAKDQDYEGFYAYEMGIRRQLYYFTIGITLSHKKEEEVFKRAYEVMNILRSGLSETSPIL---PTPKPIARTHNLYHYQILIKYRLEDELGSTLNQV................................................................................................................................................................................... |
774 |
| 14 | -15.900 | [V] COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases |
ali follow.. |
11 | 96 | ................................................................................................................................NILSVFHKL-AVHEYHNDLNDAQMCLRLGFR-YYRLVTKDYDFPVPVFVLPERGENLYHQEVLTLKQQLEQQVREKAQTQAEVEAQQQKLVALN--GYIAILEGKQQETEAQTQARLAALEAQLAEKNAELAKQTEQERKAYHKEITDQAIKRTLNLSEEESRFLIDAQLRKAGWQADSKTLRFSKGARPEPGVNKAIAEWPTGKDETGNQGFA--------DYVLFVGLKPIAV----------VEAKRNNIDVPARLNESYRYSKCFD-VHEAVPEYETSWQDTSGKQRFKIPFCYSTNGREYRATMKTKSGIWYRDVRDTRNMSKALPEWHRPE----SEPQKQNQWFADNPGMSELGLRYYQEDAVRAVEKQQEILLAMATGTGKTRTAIAMMFRLIQSQRFKRILFLV-RSLGEQALGAFEDTRINGDTFN------SIFDIKGLTDKFPEDSTKIHVATVQSL----------------------------------------------------VKRTLQSDEPMPVARYDCIVVDEAHRGYILDKEQTEGELQ------FRSQLDYVSAYRRILDHFDA--KIALTATPALHT---------------------------VQIFGEPVYRYTYR------------------------TAVIDGFLID---------------PIQIITRNAQEGVYLSKGEQVERISPQGEVINDTLEDDQDFEVADFNRGLVIP-------------AFNRAVCNELTNYLDPTGSQK---------------TLVFC------VTNAHADMVVEELRAAFKKKHDAIIKITG-DADKDARKVQTMITRFNKERLPNIVVTVDLLTTGVDIPSNIVFLRKVR---SRILYEQMKGRATRLCPEVNKTSFK-------FDCVIYSTLESVDTMRPVVVRPKVELQTLVN--EITDSETYKITEADGRSFAEHSHEQLVAKLQRIIGLATFNRDRSETIDKQVRRLDELCQDAAGV............................................................................................................................................................................. |
955 |
| 15 | -15.600 | [L] COG1111 ERCC4-like helicases |
ali follow.. |
12 | 13 | .....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EKIEARTYQQLLAADVIRKGNSMIVAPTALGKTVVAVLVAAERLRKYRGSKVLILSPSPLAIQHEESFREFMLATCTSLTG--SIKPEERKERWI-----KSQIISATPQTV-----------------ESDILAGRYDLRD-------------------------------------VSLIVFDECHRASNYIQNARHPLILGLTASPGADEDKIKTVCENLFMNE------------VVVKTEGDPDVRPYLKPIKIEWVKVRMTPELEDIRELLRKVLKNRLKMLKNLGVIDTISVGKKDLLKARGRVQNRIARSTSPPRACYRAISLLASCINVEHALELLETQIRPLHQYLLRLKEKKTKAAKG------LLADPDFTRAMHLTRRAMMSGVEHPKLDRLMEILKRELKGDEAR-----------------IVFTQF-----------DTLEEIYQRCKREGINAVKFY--EKGLTQKQQRDIIKSFRMGNHDVLL-STSVAEEGIDIPSVDLVVMY-EPVPSEIRMIQRRGRTGRKRK-----RMVVLITEKTRDEAYYYSSIRKERSMKENLRG........................................................................................................................................................................................................................................................ |
500 |
| 16 | -15.100 | [KL] KOG1123 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 3`-5` helicase subunit SSL2 |
ali follow.. |
13 | 326 | ...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LKPAAVLRPYQEKSLRKMFGNGRAVIVLPCGAGKSLVGVTACCTVRK-----RALVLCNSVSVEQWKQQFKMWSTADDSMICR---FTSEAKD------KPMGCGILVTTYSMITHTQKRSWEAEQTMRW----------------------------------------------LQEQEWGIMVLDEVHTFRRVLTIVQSHCKLGL------------------------------TATLLDDKIADLNFL-----------------------IGPKLYEANWL----------------------------ELQKKGYI-----------------------ARVQCAEVWCPMSPEFYREYLTTKTSKKMLLYVMNPSKFRSCQFLI-------------------------------------KYHEQRGDKTIVFSD----------NVFALKHYAIKM--------NKPFIYGPTSQNERIQILQNFKFNSKVNTIFVSKVADTSFDLPE-ANVLIQISSHGGRRQEAQRLGRILRAKKGAIAEEYNAFFYT-SQDTMEMSYSRKRQRFLVNQGYSYKVITHLKGMDTDSDLMYGTLQLVLSASDLDCEDEKLPGEPGYRPSGSGGAVRRVGGLS............................................................................................................................................................................................. |
768 |
| 17 | -14.600 | [S] COG3421 Uncharacterized protein conserved in bacteria |
ali follow.. |
10 | 50 | ....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NLKYPFFEWQKSALENFVI-THLLFNMATGAGKTMMMAALILYYFEKGY-RHFLFFVNQNIVDKTENNFIDPAHAKFLFTEKILQGDTVIPIRKVEMFSPHSDGIEIK-----------------------------------------------FTSIQKLYNDIHTERENQTTLADL--LVMLGDEAHHLNAQTKGKKQDELDLEAEIERKGWEHMVLELLLNKNGNPGQNVLLFTATLPENAIITKFGLKEFLQKGYTKEINLVSSTL--------------------NKKERVLHALLFAWYRHQIALKYGIANFKPV--------------MLFRSKTIDESKADYSAFLNWAENVQADDFEFLDTFSGSLNNSDNANEQGKTRTEQALKFMQDNKFGFAHLANWVKQNYQKHN-----------------------------------IITNSETNKNK--------------TEKTDSETEKLLNNLEANPIRAIF-TVDRLTEGWDVLNDIVRLYE-----KTAAEKQLIGRGVRKQPNKRKFDNDMQHELRILEELFYYTHDEQSRYISELKNELRKDGYLPEKDDDKVLATFKLKSEFADNKDFRELLIWANKKIPNPNAKSNNADSLQANPQTLS......................................................................................................................................................................................... |
625 |
| 18 | -14.300 | [A] KOG0348 ATP-dependent RNA helicase |
ali follow.. |
13 | 52 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................APTLVQAQAIPVILSGRDVLVNAPTGTGKTIAYLA----------------------------------PLIHHLQGHSPKVDRSH--------------ALVIVPT--RELCLQVYETLEKLLHRFHWIVPGYVMGGEKKAKEKARLRKGISILIATPGRLLDHLKNTASFVHKNLRWVIFDEADSILELGYGKEIEQIIKLLGSGQNEQGE-----DDIVPKGIQKQNLLLSAT-LNDKVNDL----------------------------------------------------------------AKLSLDDPVMIGLDNTKLQQNLSIESPAAPDSDAEDMVIHVNKSANPLSEDYGIPSQLVQRYLRVPCGARLVAL-LSVLKNLFEREASQKV----------------------------------VVFFST-----------DAVDFHYSLLSEFQWPPNKTFRLHGSMEQEDRRSAFGTFKTEKQAVLL-STDVAARGLDFPK-VRCIIQYDCPGEATEYVHRVGRTARIGEKGEALLF---------------LQPIEIDYLKELKKHGASLTEYPLMKVLDKFPIPGNMPRIKKVLSLESHPWVISLQRALESLTYAEPKMKSLAKNAFVSWVRGYAAHKGELKSI......................................................................................................................................................................... |
546 |
| 19 | -14.300 | [L] COG4581 Superfamily II RNA helicase |
ali follow.. |
15 | 279 | .......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FELDNFQKEAIYHLEMGDSVFVAAHTSAGKTVVAIALAQKHMTKAIYTSPIKALSN----QKFRDFKHKFEDVGIL--------------------TGD-------------VQVNPEGSCLLMTTEI-------------------------------LRSMLYRGADLIR----DVEFVIFDEVHYVNDLERGVVWEEV-------------IIMLPPHVT-------LILLSAT-VPNT---------------------KEFASWVGRTKKKNIYVISTLKRPVPLEHYLWVKQNMFKIVDQHGRFLMDGYKSANDA-LKKPDKPVIAKDNKNSARGRGAARGRGVQTNMMRGRGSAKSVERRDANTWVHLIGHLHKQNLLPVIV-------SKKRCEEYVDTLTNR------------DLNNHQEKSEVHVVIEKAVARLKKEDRLLPQIGRMRE-MLSRGLAVH-----HGGLLPIIKEIVEILFQRGLVKVLF-ATETFAMGVNMPAKSVVFSGTQ---LPGEYTQCSGRAGRRG----------------LDVTGTVIILSRSELPDTASLRHMIMGPSSKLISQFRLTYNMIL-----NLLRVETLRIEDMIKR----------SENVNQTLVPQHEEKIKSFEEKLSALKK....................................................................................................................................................................... |
782 |
| 20 | -14.100 | [R] COG1201 Lhr-like helicases |
ali follow.. |
13 | 25 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RPTEPQERAFPHILDGKHTLLIAPTGSGKTESAVLPVFNA----ILKKKLYITPRALNRDMLSRIEVMGKLLDIKVQVRHDTPQSERQRQSRN------DLLITTPETLQAMFSGSRLRKNM-----------------------------------------------------TVTHVVVDEIHEL-----------------ASSKRGAQLAIGLERLVEISGEFQRIGLSAT-----VGNPWEIAKFLAGANRDFTVIE----------------------------------------------VALLKLLEFDVISPQVSGEAEDREVMEIARTVGCEPEFASHLSLIRKI---------EESQSTLIFVNTRQSA------------------------------------------------------------------------EALAAGFRKLG---ASIGVHHGSLSFEARVEAEEAFKAGALRGLI-CTSSMELGIDIGN-VDRVVQYGSPRQVSRLLQRVGR---AGHRLHEVSRGTVLSMEADD------TAESMAITKAALEGRVEDISPHVNSLDVVANQIAGMVMDFGE------VGIEKIFRILRRAYPFRDLRPEELQRVVDQIGDYRLVWHEKGSQIVKKRRKSWQYYYDNLSMIPDEKKYEIYDIVGGRSIGVLDEAFVVNFAEPGAVFITKGDMWRVIEMPDREREPSRDRIKVEPVEGMGEVPSWTGEEIPVPFEVAQDVGKLRAEIAALLRDGLEDEAVAEKLRLKYPVSRSAVLELIRLIRDQVEG............... |
619 |
| 21 | -13.500 | [V] COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases |
ali follow.. |
10 | 7 | ..........................................................................................................................................................................................................................................................................EAALIKKLETEGWTYREDLSNV-SIKKLEEHWRDILNET------------NAHKLNGVPLSEIEFGLILQELQRI--TPYDAQLLLVGAGGVGSIPITRDDGSSLEVEIFYEDDVAGGRSRYGLTTKRIIDVA--LINGIPVVHIEKDEHLQNQWRAFEQLKGYHGDGLYKGLFEQYNKT--ENNKDITDAFEFIHQVMSIPALHRLVTVNMIPDASNDNIMVRSYQIQATREILQKEGGYIWHTTGSGKTVTSFKVAQLLASAPRIKNVLFIVDRIDLIQTLENFKSF-------AHFKNRIKKVNGRELKRELKRKGSSQILLI---------------------------------------------SVQGLTKAVKKGLENDDWNV---------IIMDEAHR-------SASGESV-----------------KLIKKALKKTTWFGFTGTPNFYS----------------------------------DEINDVKTTREISTHDIFGKRLHTYTIKD---------------------AIGDGNVLGFDVTYFKPHWVVEHPQEDFSEKDYEKEVYQSDVYRQEVVKDILDNWTKTSSGALIAGKREENAFQAMFAVSGKQAAVNYYNIFKSKGSHLNVAMTFSRDESNEHGTKEQNEALKIAIKDYTEKFNVPSILDAKDPARAYMLDITKRLARKRPYNGKEKDRLDLVI--SDQLLTGFDSK--FINVIYMDKMLKEGMLIQAISRTNRDLNSKPHGKVRFYRQGDEMREFVENALRIYTR-----GGNDTLQEAEEETKNQLPKDLENDDILAKP--QSHQINELEEAVLRLKELAGDDFSQVPRGQNDLKEFVGLALTTQTRIQQLIQQGYELGSEIEEGRMVRLNISSIDEFGALQARLYDAKEKLPPEERPDLTEI-GIEFYHHEIIDYDMLVELLNTFMDEKNKSNKDAIEKHIVPMDEESQHEIHGIVDDIEAGNITEHFTTDSLQETRKKYRTEHRELKVRRAANQKVNGNRIVEAFDLFLPGHTLIDNP |
961 |
| 22 | -13.400 | [A] KOG0350 DEAD-box ATP-dependent RNA helicase |
ali follow.. |
11 | 99 | ................................................................................................................................................................................................................................................................................................................................................................................................................................................SKPHVKNITSVLPKWLAEPITVDPNTTVEFSSLISSKLVERLQKQNIT--------RGFAVQAAVLPLLLQDGDVCVSAATGSGKTLSYVIPIVQSHRTVPRLRCVVIVPRELTVQVAKTFEYYMSGAGLAWTGQKSLRHETYQ-LNGDENECRIDVLVSTPGRL------------------------VDHIRNDESFSLQHLR-----------------------------YMVIDEADRLLDQSFQDWVDTVMEISHPKCLQNKSNILDLDQNISPTFLPDIDTLLPYRLPSPLQKLV---------------------FSATLTRDPSKIA-------------SLKLHNPRLVLVQNKDMEVDDGGEIEDDAIVFSVPPTLQEYHVSVSSEKPILLYHLIHSK-------------NLTNILCFVKSNEAAARLHRLL-------------------------------------------------------------------ELIHESLNQSFSCGLF---TSSLSRDERKKIISRFATGDLNLLV-CSDLMARGIDVAN-TQNVINYDPPLSVRSYVHRIGRTARAGREGFAWTLVQ-------EGHHFSKLVKQLRRTLPIKRIKIEFSHISE............................................................................................................................................................................................................................................... |
574 |
| 23 | -13.200 | [LK] COG1197 Transcription-repair coupling factor (superfamily II helicase) |
ali follow.. |
15 | 550 | ............................................................................................................................................................................................................................................................................................................................................................................................................................................................EAWAKSRQKAAEKIRDVAAELLDVYAQREAKKGFAFKYDRE-PFEETYDQEMAINAVISD-DRLVCGDVGFGKTEVAMRAAFLAVMNH--KQVAVLVPTTLLQQHYENFKDRFANLPVNVEVLSRFTAKEQKQILENLAEGKVDILIGTHKLIQS----------------------------------------------------------VKFNDLGL--LIIDEEHRF-------------GVGQK------------EKIKQLRANIDILTLTATPIPRTL-------------NMAMNGIRDL-----------SIISTPPARRLSIKTFVRQNDD----------------------------------------------LVVREAILR-------------------EILRGGQVYYLHNDV----------ASIENTAEKLTAL-------------------------------------------------------VPEARVIVGHGQMRERELERVMSDFYHQRYNVLV-CSTIIETGIDVPTNTIIIERAD-----AQLHQLRGRVGRSHHQ----------------AYAYLLTPPPKMMTKDAERRLDALENLDNLGAGFILATHDLEIRGAGELLGNEQSGLDAAVKALKEGREPSLEELTQQQADIE--DDYLGDVNMRLSFYKRIAAAESKAELDELKVELIDR................................................................................................................................................... |
1051 |
| 24 | -12.800 | [L] COG1110 Reverse gyrase |
ali follow.. |
14 | 63 | ...............................................................................................................................................................................................................................................................................................................................................................................................................................................................LYRLNKEVSEVEDLFKRATGF--------------------RFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYFAIKG--KRSYIVVPTTLVVQTVKKIQDMMERAGVLVYYHGNLKKKEKEEALKRIKDGDFDILVTS--------------SQFLATRFDEL-----------------------------------------LRDKRFDLIFVDDVDAFKASKNIDRSLLLLGFTQEVINRAWEV------------------------------------------------------------------------IKLKKQLAKLLQ-------------------------------------AQGKEKEVEELNKEIEKIEREIERYRRENNIGI--LIVASATGSARGDRIKLYRELLGFEVGSGRSV-LRNIVDTYIIPERSIEEEVENLLRKLKGGLIFVPIDKGIEFAE---------ELTNYLKSKGFKVELVS--------AKNKRGLELFERGEVDYLVGVATYYGTGLDLPHLIRFAVFAGVPKFRFSMDLEQ-RLIRNIPQYELMKIEEALAEGGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVEGKLYIEIPD--VRTYIQASGRTSRLSVIIVDDQKVFNGLIRQMRWRFVEFEIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSAL------MIVESPNKARTIASFFG................................................................................................................ |
658 |
| 25 | -12.800 | [R] COG1204 Superfamily II helicase |
ali follow.. |
9 | 931 | ................................................................................................................................QFMRRLADCLNAEVSLGTVRSIEDGVD--WLGYTYLYVRMLRSPALYSVGPEYDDD------KYLVQKRADLLHSAAILLEKYNRQSGTLTATELGKVAASYYVTHNSMAIYNRLLMQTTSFIELFRVEFKHIPVREEEKVELAKLLERVLDEPAAKINALLQSYIS---RQRLDGFALVADMVYVTQSAGRIMRAI---------FEISLRRGWSSVATLSLDTCKMIEKRLWPTMSPLRQFPNCPSEVIRRVEKKEFPW-GVPKEGRRVYNMVQSFPRLSVEAHVQPITRSLVRVELVINSQFNWDDHLSGTSEAFWILVEDVDGDRLLHYEQFFLLSLNNPSFISLYPNFKFFNK-------QTQVFNSVYTNDSVFIGAPNGSGKTVCAELALLHHWSQEDYGTAVYIAPQEIVDRRYEEWYGKFSDLGDGKVLVK--------------LTGERSQDLKLIQVADLIFCTPS----------------------------------------QWDSLSKRWRSMRSIQKVDF--YICDELQ----------------LGGFYGPLYEIVISRIRYMAVQLEKNIRVVGLSVSVANA------LGEWLG---TSPQCIFNFSP------------------KDRPNPLTIHLQSFSITHFPSL----MLAMSKPIYRSLKNFISQRKSTIVFTPDRKVAKQLAFDLVTFSMA--------DEDEYLFSLMENEAFNKVEDAAL-----------------------------------------------------------------------QQSLKHG-----IAYISEITSSNDQNIVQYLYRHGLIKVLI-ASRDVIYSLKAKSNAVIVMGTQYDYPISELLQMLGFTASISELSQVILMTVTTKKEYYKKFLNEPLPMESHLQVWLFVSEISTQTIESKQDAVDLTWSYMYRRLVANPAYITHESVSEFLSDL............................................................................................................................................................................................................ |
1823 |
| 26 | -11.900 | [A] KOG0347 RNA helicase |
ali follow.. |
12 | 213 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EPTKIQKACFNVAAYQGKDVIG-ETGSGKTLAFGLPILQRYAADGYLRALIITPRELALQVTEHLENAAKNLSVKVVP--GMFSEKQERRLKE------EIVVATPGRL-------------------------------------------------WELMSAGEKHLVELHS--LSFFVLDEADRMVERGHFRELQSILDLLPVTDKPNEG--------TQTVKSNDTVLNVPKKKRQTFV------------------------FSATIALSSDFRKKLKRGSSKSKQSSSGEVNSIEVLSERAGMRD-------------------NVAIIDLTTTSILAPKIEE--------------------SFIKCEEKEKDAYL-YYILSVHGQ--------------------------------------GRTIVFCTS-----------TDLRHISGLLKILGLDVCTL---FSEMKQRARLKSIDRFRASENGILI-ATDLVARGIDIKN-VRTIIHYKLPHSAEVYVHRCGRTARAFADGCSIALIE--LCKSFSMESVKIFPLDNSYMPAVRKRLYLARQIYEIERKGSRENADRTWLKK----HAESMELELDDEESEEERVDNVRQRKATSARLNKLKEELSTLLSH............................................................................................................................................................................. |
714 |
| 27 | -11.500 | [A] KOG0331 ATP-dependent RNA helicase |
ali follow.. |
13 | 52 | .........................................................................................................................................................................................................................................................................................................................................................................................................................................................PKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPNFPANVEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIHQPFLERGDGPICLV--------------LAPTRELAQQVQQVAAEYCRACRLKSTCI------------YGGAPKG---------PQIRDLERGVEICIATPGRLIDFLECGKTNLRR-------------------TTYLVLDEADRMLDMGFEPQIRKI--------------------VDQIRPDRQTLMWSAT-----------------PKEVRQLA----------------------------------------------------------------------------------EDFLK---------------------DYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKT----------------IVFVETKRRC----------DELTRKMRRDGWP---AMGIHGDKSQQERDWVLNEFKHGKAPILI-ATDVASRGLDVED-VKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFT--NNIKQVSDLISVLREANQAINP............................................................................................................................................................................................................................................................ |
469 |
| 28 | -11.400 | [A] KOG0341 DEAD-box protein abstrakt |
ali follow.. |
12 | 7 | ........................................................................................................................................................................................................................................................................................................................................................EADSYIEYVSVAERRAIAAQKILQRKGKASELEEEADKEKLAEAKPSLLVQATQLKRDVPEVSATEQIILQEKEMMEHLSDKKTLMSVRELAKGITYTEPLLTGWKPPLHIRKMSSKQRDLIRKQWHIIVNGDDIPPPKFPRPVQPTPIQVQGLPVILAGRDMIGIAFTGSGKTLVFVL-------------PMIM---IALQEEMMMPIA--PIGLIVCPS---------RELARQTYEV---VAPLVEAGYPPLRSLLCIGGIDMRSQLEVVKRGVHIVVATPGRLKDMLAKKKMSLDA-------------------CRYLTLDEADRLVDLGFEDDIREV--------------------FDHFKSQRQTLLFSAT-----------------PTKIQIFARSALVKPVTVNVGRAGAANLDVIQEVEYVKQEAKIVYLLECLQ--------------------------------------------------------------KTSPPVLIFCENKADV------------------------------------------------------------------------DDIHEYLLLKGVEAVAI---HGGKDQEDREYAISSFKAGKKDVLV-ATDVASKGLDFPD-IQHVINYDMPAEIENYVHRIGRTGRCGKTGIATTFINKNQSETTLLDLKHLLQEAKQRIPPVLAE........................................................................................................................................................................................................................................................ |
530 |
| 29 | -11.300 | [U] COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase) |
ali follow.. |
12 | 2 | ............................................................................................................................................................................................................................................................................................................................................................................................................LGFAKKLFGSSNERKVKTLATRVAKINAYEAEYAALSDEALKGKTAEFKARLEKGETLDDILNEAF---------------AVVREASKRVLGMRHFDVQMVGGMVLHFSGISEMRTGEGKTLVATLPTY-LNALEGKGVHVITVNDYLARRDADWMGQVYNFLGLSYVIVNGLSQGERQRAYRS------DITYGTNNEFG----------DYLRD----------------------------NLVYSVDEMVQRGHNFAIVDE--VDSILIDEART------------ISGPTEDRSSFYKTIDVLVKELILDKSM------------------FDHDEKQKQVILTEDGQEKIEEILMSYDAANVSVVHHVNQALRANILYTR-----DKDYIVKGGEVVLIDEFTGRMMTGRRLSEGLHQAIEAKEGADIQP-IQNYFRLYKKLSGMTGTASTEAQEFMSVSEIPTNRTIQRIDDDDEVYRTEREKNEAILKQIADCHVRGQP-----------------------VGTVSIEKSEELSKLSFEKDGKKVKGIPHQVL----NARFHEQEAVIVA--DAGVPGAVTIATNMAGRGTDIQLAAGGLFVLGTERHES--NQLRGRTGRQGDPGREDDLLRIFAGERLDAIMRTFGVQEGEAITHKWLNNAIATAQKRVEQR---NYEIRKNLLKYDDVVNDQRKA................................................................................................................................................................................................................... |
670 |
| 30 | -11.200 | [R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster |
ali follow.. |
8 | 7 | ....................................................................................................................................................................................................................................................................................................................................................................................................................................................SRQVADSVAAFLLNSPLFNGENNDNVSMLEQFLAQPELKGPYLSFPNLTLPFPPHAHQARAFQRLGSDAPTLVATGTGSGKTFPLLNHCAGASQAGV--KAIIIYPNALATDQASRFAKTFVGDS---EIEPSKKMSAEKVITCKLRESPPDILLTNYKMLDYLLMRPGDQPLWRYNQPGSLR-----------------------------------------------YLVVDELHTFD------------------GAQGSDLACLVRRLKHHIGQRFACVGTSATVGDELGQLLDYAKTIFDQPFTDDAVYTAAEYLQNYAIAYSQYPGPEVASALDPQSYATPVAY--LNGQIPLWFPDSDLQLPDDLESDDGREKRIALGSLLRRHSVMHVLLHDLQGGILSERECLENLQVMLQSILALIAQARLEVPETEHDRQKRLQAKKARSQLWLREMRRLVASVAKTPRLVFADDVAVEDRELPVIHCATGWASLRHGQSVQLETDLDGIYRQFFEKGRSIVLAFPDNNEKAVSGAHQKLCPTCLKL--QGISILGSRAASLSAVMIHQLYG------SQFNEHKKLIVQDAAHRASFFTARTWPLMIRGQIASVLSEK----ETLPLDAFAARVCQQTRERSPDDAHFAANVIAPNMQWLNDYQTLKNEGKLAENSDLPELVSLRLDWEVYSEFTLRARIGRTLEAT......................................................................................................................................................................... |
760 |
| 31 | -11.200 | [A] KOG0345 ATP-dependent RNA helicase |
ali follow.. |
13 | 38 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FCTPVQAATIPLLCSYKDVAVDAATGSGKTLAFVVPLVEIKPHQV--MGVIISPRELSTQIYNVAQPFVSTLANVNSV---VGGREVKADMKIIEEEGCNVLIGTPG-----------------------------------------------------RLSDIMERMEILDFRNLEILILDEADRLLEMGFQRQVNYI--------------------ISRLPKQRRTGLFSAT-QTEGVEEL-----------------------AKAGLRNPVRVEVRAKSKSESSQQLTNSKTPSGLHLEY----------------------------MECEADKKSSQLVDLLIKN-------------SDKKLIVFFMTCASVDY---------------------------------------------------------------------WGLVLSKIPALKSIS---LIPIHGDMKQNARDKALASFTKASSGALL-CTDVAARGLDIPG-IDYVVQYDPPQDPNMFNHRAGRTARLGRQGRAIVF---------------LLPKEEAYVEFMRIRRVPLEERK-CSEDASDVIPIIRSAAMKDRAVMEKGL.................................................................................................................................................................................................................... |
431 |
| 32 | -11.000 | [A] KOG0336 ATP-dependent RNA helicase |
ali follow.. |
12 | 244 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KPTPIQSQAWPIILQGIDLIVVAQTGTGKTLSYLM-------------PGFI---HLDSQPISREQRNGPGMLVLTPT---------RELALHVEA---ECSKYSYKGLKSICI--------RNGQIEDISKGVDIIIATPGRLNDLQMNNSVNLRS-------------------ITYLVIDEADKMLDMEFEPQIRKI--------------------LLDVRPDRQTVMTSAT-----------------PDTVRQLA----------------------------------------------------------------------------------LSYLK---------------------DPMIVYVGNLNLVAVNTVKQNIIVTTEKEKRALTQEFVENMSPNDK-------------------IMFVSQKHIA----------DDLSSDFNIQGISAESL---HGNSEQSDQERAVEDFKSGNIKILI-TTDIVSRGLDLND-VTHVYNYDFPRNIDVYVHRVGYIGRTGKTGTSVTLIT--RDSKMAGELIKILDRANQSVPE............................................................................................................................................................................................................................................................ |
595 |
| 33 | -10.900 | [L] COG0514 Superfamily II DNA helicase |
ali follow.. |
14 | 37 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QFRVGQQEVIEAALAGRDSLVIMPTGGGKSLCYQIPALVLEGVTLVISPLI----SLMKDQVDQLKANGVAAECV---NSTLAREELIAIYNRMHAGQLKLLYVS--------------ERVLTAEFIER-----------------------------------------LSHLPLAMIAVDEAH---------------------SQWGHDFYASLGQLKQRFPNVPVMALTATADDA-----------TRHDIMQRLQLNEPHQYLGSFDR--------PNIRYMLVEKHKPVSQVIRYLETQRGQCGI-------------------------------------------------------------IYCGSRKKV------------------------------------------------------------------------EMLTEKLCGNHI---RAASYHAGMDADERAWVQEAFQRDDLQIVV-ATVAFGMGIN-KPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMMLYDPA-----DMNWLRRMLDEKPDGAQKQVESHKLTAMGAFAEAQ.......................................................................................................................................................................................................................................... |
390 |
| 34 | -10.800 | [A] KOG0342 ATP-dependent RNA helicase pitchoune |
ali follow.. |
14 | 38 | ............................................................................................................................................................................................................................................................................................................................................................................................................................QDEDDYEQEEENEDADQNTSVESESEELDNENEDERVQKSVNLNASSTSDIEKFSDLQLSENIQKAIKEMGFE---TMTEIQKRSIPPLLAGRDVLGAAKTGSGKTLAFLIPTIEMLYALKFKPVIIISPRELALQIFGVAKELLKYHHQTF------------------------GIVIGGANRRA--------------------------------EADKLVKGVNLLVATPGRLLDHLQNTKGFVFRNLRSLVIDEADRILEIGFEDEMRQI-----------------MKILPSENRQTLLFSATQTTKVEDLARISL-----------------------------------------------------------------------------------------------------------------------KPGPLYVNVDSGKPTSTVEGLEQGYVVVDSDKRFLLLFSFLKRNLKKK--------------------IVFMSS-----------ASVKYMAELLNYIDLP---VLDLHGKQKQQRRTNTFFEFCNAEKGILL-CTNVAARGLDIPA-VDWIVQYDPPDDPRDYIHRVGRTARGTKGTGKSLMF--------------LAPSELGFLRYLKTAKVSLNEFEFPANKVANVQSQLEKLVSKNYYLQQSAK.................................................................................................................................................................................................................... |
491 |
| 35 | -10.800 | [LKJ] COG0513 Superfamily II DNA and RNA helicases |
ali follow.. |
17 | 24 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................APTPIQAGAIPPALERKDVLGIAQTGTGKTASFVLPMLTLLEKGRARRTLILEPRELAAQVEENFVKYGINHRLNV------------------------ALLIGGVSFE--------------EQERKLERGADVLIATPGRMLDHFERGKLLLTG-------------------VEILVIDEADRMLDMGFIPDIERI--------------------CKLIPFTRQTLFFSAT-MPPEITKL------------------------------------------------EQFLHSPVRIEVAKASSTAKTVTQRLVKSGK---------------------------------------------------KDWDKRAVLRDLIQSEGDSLKNA------------------------------------IIFCNRKKDV----------SELFRSLTRHEFDAGAL---HGDMDQRARMAMLSSFKDGKLRLLV-ASDVAARGLDIPD-VSHVFNFDVPIHAEDYVHRIGRTGRAGRSGKAFTIV..................................................................................................................................................................................................................................................................................... |
351 |
| 36 | -10.700 | [J] KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins |
ali follow.. |
11 | 159 | ..........................................................................................................................................................................................................................................................................................................................................................................................................................................................QYDVTITPEVSSKSVNRAIIAELVRLYKESDLGRRLPAYDGRKSLYTAGPFTWKEFSVKIVDEDDGIINGPKRERSYKVAVARANMHHLGEFLAGKRADCPQEAVQILDIVLRELSVKRFCPVGRSFFSPDIKTPFYQSIRPTQMGLSLMASAAF--------IEPLPVIEFVAQLLGKDVLSKPLSDSDRVKIKKGLRGVKVRVAGLTTQPTRELMFDENCTMKSVIE--YFQEMYGFTIQHTHLPCLQVGNQKKASYLPMEAKRLNEKQITALLKVTCQRPRDRDILRTVQHNAYDQDPYAKEFGMNISEKLASVEARILPAPWLKYHENGKEKD-FSRSVQENVARGFCNELGQMCEVSGMEFNPEPVKTKGKELELLLAHVFKISKQYLANVSLKINKMGGRNTVLVDAISCRIPLVSDIPTIIFGADVTHPENGEESSPSIAAVVASQ--------DWPEVTKYAGLVCAQAHRQELIQDLYKTWQDPVRGTVSGGMIRDLLIATGQKPLRIIFYRDGVSEGQ----FYQVLLYELDAIRKACASLEPNYQPPVTFIVVHHT--ANNHRDKNSTD----RSGNILPGTVVDTKICHPTFDFYL-QGTSRPAHYHVLWDENNFTADGIQSLTNNLCYTYARCTRSVS.............................................................................................................................................................................................................................. |
926 |
| 37 | -10.600 | [V] COG3587 Restriction endonuclease |
ali follow.. |
10 | 1 | ......................................................................................................................................................................................................................................................................................................................................................................................................................................................MSGFNYE----KNQPHQMRAVSAVLGVFDGATPKYRTAD------ENPELLFAAKQYANNILKVQSQNGIISMETGTGKTYTYTQTMFELHRWLGVFKFIVVV----------------PTLSIKAGTQQFLQSKALAEHFEQDFGGDYEGVRLKTYVVESAKKNKGKKSNAPITIEQFVKAENKKEIHVLLINAGMVNSSSMNDTGDKALKDLFDNPVDALAAV--PFMIVDEPHKFPTRDSAKTWGNIKRLKPQYILR----------------------YGATFNDEYYNLLYRLVDAFNDGLVKGVRVFQEEM-KLVSSDGKEAKFELNEKDKKQTFKLAKGEDLAQIHPAISDLKIDKMNKTVVVLSNGLELKTGAVINPYSYSQTVQDAMMQRAVAEHFKLERALLAERAPQPKIKPLT-------ID-DIAGYRSGNELSGSLKDKFESWIRAEAARRLKTESDPFYRDYLQKTLDDVSACHGGYFSKDNTDSDDRIEQEINEIL------------------HDKEKLLS---DNPRRFIF-SKWTLREGWDNPN-VFQICKLRSSGSTTSKLQEVGRGLR-ARVRDVPYKLNYFVDSSEKDFVKQLVGNDNSFQEEISKKFTEELKQKILQKYPDIKPLVLVNQLFLDGIIDDNENFAEDGYDKLKAAYPEAFPKGLDKGKVSNAKDEGKDTIIMREGKYEELKALWELIHHKAVLQYK---IKDEAEFADLFTAYLHE................................................................................................................................. |
701 |
| 38 | -10.500 | [A] KOG0340 ATP-dependent RNA helicase |
ali follow.. |
16 | 80 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KPTPVQTHCVPKILAGRDVLGLAQTGSGKTAAFALPILHLAEDPYGVFALVVTPRELAFQLAEQFKALGSCLNLRC------------------------SVIVGGMD--------------MLTQTMSLVSRPHIVITTPGRI--------------KVLLENNPDVPPVFSR--TKFLVLDEADRVLDVGFQDELRTI--------------------FQCLPKSRQTLLFSAT-MTSNLQAL------------------------------------------------EHSSNKAYFYEAYEGLKTVDTLTQ----------------------------------------------------QFIFEDKDAKELYL-VHILSQMEDKGIRSAM-----------------------------------IFVSTCRTC----------QRLSLMLDELEVENIAM---HSLNSQSMRLSALSKFKSGKVPILL-ATDVASRGLDIPT-VDLVINYDIPRDPRDYVHRVGRTARAGRGGLAVSII-----TETDVKLIHKIEE................................................................................................................................................................................................................................................................... |
419 |
| 39 | -10.300 | [A] KOG0332 ATP-dependent RNA helicase |
ali follow.. |
9 | 163 | ...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EEAHEQVPVPADIALLNKFIQKEVKMMKDVVVDVQRQDPKSPLYSISSFRELRLKPEVLKALDTM-NFQFPTRIQE-TALPLLLMEPPSNL------IAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLAPTLELAKQIGEV-VEKMGKFIDNLKIHYAIKGGNMAAMRGRKLTEQIV---GITRDYLQKYKC--------IDPSKIRCLVLDEADVMIY-HQGFTDISTTIYNMVEDASDSVQSMLPVINFATKIIKNAIVVMLKREEQALPNIKQFYVQC-----ACRDSKYAAIVNLYSGLAVASSVIFCHTKASV----------MWLYENMRARGH---QVDVLHGDMTVVERADTIIHFKRGDFKVLI-TTNVFARGIDVAQ-VSVVINYDLPIKCETYLHRIGRTGRFGKTGIAINLID------------EDSMNMINVLENHFQMKIARMDPSNLVELEAIEMA..................................................................................................................................................................................................................................... |
613 |
| 40 | -10.300 | [A] KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1) |
ali follow.. |
16 | 408 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QLNSSQSNAVSHVLQRPLSLIQGPPGTGKTVTSATIVYHLSKI--------------------------HKDRILVCAPSNVAVDH---LAAKLRDLGLKVVRLTAKSREDVSVSNLALHNLVGRGAKGELKNLLKLKDEVGELSASDTKRFVKLVRKTEAEILNKADVVCCTCVGFRTVLIDES-----------------------TQASEPECLI------------------PIVKGAKQVILVHQQLGPVILERK--------AADAGLKQSLFE-----------RLISLGHVPIRLEVYRMNPYLSE--------------------------PSNMFYEGSLQNGVTIEQRTVPNSKFPWPIR------------------------------------------------------------GIPMMFWANYGREEISANGTSFLNRIITKLFRDGVKPEQIGVITPYE--------------GQRAYILQYMQMNGSLDKDLYIKVEVASVD-----------------QGREKDYI-ILSCVRANE---------QQAIGFLRDPRR-------------NVGLTRAKYGLVILGNPRSLARNTLWNHL............................................................................................................................................................................................................... |
824 |
| 41 | -10.300 | [A] KOG0335 ATP-dependent RNA helicase |
ali follow.. |
16 | 254 | ...................................................................................................................................................................................................................................................................................................................................................................................................................................DEDSIFAHYQTGINFDKYDTILVEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYT-------------KLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLL-------------PIL---AHMMHD-SRFKELQEPECIIVAPTRE-------NQIYLEARKFSFGTCVRAVVIYGGTQLG---------HSIRQIVQGCNILCATPGRLMDIIGKEKIGLKQ-------------------IKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLM---------------------------------------------------FSATFPEEIQRL-----------------------------AAEFLKSNYLFVAV-------------------------------------------------------GQVGGACRDVQQTVLQVGQFSKREKLVEILRNI-------------------GDERTMVFVETKKKA----------DFIATFLCQEKISTTSI---HGDREQREREQALGDFRFGKCPVLV-ATSVAARGLDIEN-VQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDLESDNHLAQPLVKVLTDAQQDVPAWLEE........................................................................................................................................................................................................................................................ |
673 |
| 42 | -10.200 | [V] COG1002 Type II restriction enzyme, methylase subunits |
ali follow.. |
9 | 29 | ...................................................................................................GIFPKEIHSVEEHPDSVVINGSVFNSKIKNQRSQLVKQIKEKGYEQVMEEVTYTWRLVALKFMEMNGCLQD-QIKVFTSTDPNKPEPDLLTNALKLDFLNLNRDLVLDLKAENKDEELYKYPFLFEKELLFPDKLLHTGSVLHDLNSIIPDEDWQEVEIIGWIYQDYIAPKKDKVVTQLF----TPHWIV--RYLVENSLGRL-VKPEQQETDFLKINSPEELKICDPA----------CGS---------HMLVYAFDLLYAIYEEEGYTPSEIP-----EIILTHNLFGIEDKRAGELAGFALTMKARGKDRHFFKKQVQPNICMLENITFEQSELDAYIDAVGS---------ELFTNAHRATLLQFAEADNFGSLIRPAAMEVS-GLLSLLESKNLSGNLSHLSTHQKVLQALKQADYLSPKYHV----VIANPPYMGNKGMNNRLKTFLQNNYADVKFSAFIVRNTELAFPKGQLGFMSPFVWSLIQLEYSGFDGATVPICTFTSENAYHPEFKGGYVRLSDFRGAENQSPKTLEAIKNPKCGWFYRASATDFKKIPGNPIAYWVSNKVRDFGNITLGDFFDTEGQNKTTDNDKYLKYHWELREKTIGVDKKWVLCAKGGSFRKWQGNIEYVIDW-KDHSARIVEEEFWYREGITWTGITSSFRYLEYGCTYETAGPTIFVKNANKYVILGYLNTPIVAKFINIMNPTLNTKIKDVQALPIIQSILFDNQVESVSLRLVNLSKSDWDSYETSTTLPFLQSEFRQPTLSETYTKLRTHWKEMTLEMQRLEEFIEAYGLQDEITPEVPLSEITLTCNPYYRYGNNKTEEELETLLMTDTVKELVSYAVKEGLILANQGEKLGDFKEKVPRATFLPDEDN----IIPILDDEYYTDDIVGRFKEF--LKHTFGAETLSENLNFIISKKNESPGKVIRDYFLKDFYKDHV--KMYKKRPIYWLFTSSEKG-------------AFNALVYMHRYDKTTLAKMRLLDFESKLDAQRSLLKKEITENSKNSGKAESELAKLNKKINELVKYDELLKNKADQMIEIDLDDGVKVNYEKFKGLVGKI.................................................................................................................................... |
1161 |
| 43 | -10.200 | [E] COG2902 NAD-specific glutamate dehydrogenase |
ali follow.. |
9 | 560 | ..................................................................................................................................................................................................................................................................LSRRVPLLENLGFNVISERTFDIGVVSEGEKRDIVLH-ELSVAAGTTLDLPHYGPKLEEAFLAAFSGKVDNDNFNRLILACGLNVREVSVLRAYARYLRQTGIVYSQEHISETFKAGFDPSIEEKKRVKKLAEIHKAIEAALSGVPNLDEDRTLRRYVNAIDATLRTNYFQKNADGTPRDLLAFKFDPKHLDGLPDPRPFREIF------VYGTEVEGVHLRFGKVA---------RGGL-RWSDRGQDYRTEVLGLVKAQQV--------------KNAVIVPV---------------GAKGGFFPKNLPAGGSRDEVFNAGRE--YKTYI---RTLLSITDNIVDDAIVPPADTLRLDPYFVVAADKGTATFSDTANGLAHEAG--DAFASGGSAGYDHKKMGITARGAWETRHFREMDTDIQTTPFTVADMSGDVFGNGMLLSEKILIAAFDHRDIFI---DPDPDTDKSFAERKRLFE---LPRSSWQDYDR-AMIISRSEKSVTLTPEAVAAIGLDKSVATPFEIMTAILKAPTDLLWFGGIGTYIKNAEVGDRANDPIRVNATELRAKVIGE-KGRIAYALAGGRCNSDAIDNSAGVNSSDVEVNIKIALASAVNSPKRNQLLASMTPDVAQLVLRNNYQQSL-------------------ISLTERLGLANREELGRLMGALEATGQLNRKVETLPNNAEFSERYASGKPLTRPEIGVLLSYAK-----LTLFDALVASPLPDEPY-PAKMQKNYANDIKAHRLHREI-VATALANAVVNGFVQKLADASGLLAADVVKAAVIVEDGFGLKR---TEVDALDGKVGGQVQNGLYATITRIFSDASRLYLQTGSAGAAAGDMATEIERLKTAIKTLSPAATKYRRELGVTEISGLLEELDTLSLLVYVPEIMRIAESAGTTLARAAESYATVSSTFRVA-RLLDASQRITPADHYESLALLRSQDQISSSRRRIVISALTEYAKEKDPVQAWYAADRVRVNRIVSELGALSES-------GDTNLARLTVAAGLLGDIVQAR....... |
1585 |
| 44 | -9.930 | [A] KOG0326 ATP-dependent RNA helicase |
ali follow.. |
16 | 48 | ..........................................................................................................................................................................................................................................................................................................................................................................................................................................AQSMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWE---KPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNQAMVIVPRELALQVSQICIQV--------------------------------------KHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDH-------------------VQMIVLDEADKLLSQDFVQIMEDI--------------------ILTLPKNRQILLYSAT-FPLSVQKF------------------------------------------------NSHLQKPYEINLMEELT-------------------------------------------------------KGVTQYYAYVTERQKVHCLNTLFSRLQINQS--------------------------------------IIFCNSSQRV----------ELLAKKISQLGYSCFYI---HAKMRQEHRNRVFHDFRNGLCRNLV-CTDLFTRGIDIQA-VNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLI..................................................................................................................................................................................................................................................................................... |
427 |
| 45 | -9.890 | [A] KOG0330 ATP-dependent RNA helicase |
ali follow.. |
13 | 11 | ..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DKKNSSLNKKIETSNSSSEKSSENNNGDSQNNEAPKTFKELGVIDELCEACEKLEAIPVVLNKRDVIGLAQTGSGKAFALPVIQELWNNPSPFFAVVLAPTRELAYQISEQF-----------------------EAIGGSIGVRSVVIVGGMDMVTQAVALSKKPHVL---GRLMDLENTKGFSLKNLKYLIMDEADRLLDMDFGPIIDKILKIIPHERRTL-------------LFSATMTSKVEKLQRASLHQPVRVAVSSKFSTVDTLIQRYLFFPFKHKDTYLVYLVNELAGNSIIIFARTVNDT----------QRLAILLRTLGFSAIPL---HGQLSQSNRLGALNKFKSGARSTLV-ATDVAARGLDIPL-VDVVINYDIPTDSKAYIHRVGRTARAGRAGKSIALV-----TQYDLEPFLRIEA................................................................................................................................................................................................................................................................... |
402 |
| 46 | -9.850 | [O] KOG0743 AAA+-type ATPase |
ali follow.. |
9 | 213 | .......................................................................................................................................................................................................................................................................................................................................................................................................................................................MDPNAKKKIIDDLERFLKRKEFYKRV-----------------GK-------AWKR----------GYLLYGPPGTGKSSLIAAMANYLK--------DLELSSIYDNGELKRVLLSTTNRSILVIEDIDCNAEVRDRILNFISFGDERIIVFTTNHKERLPLCEEIEALVDSTEVTELAEEL--QDDDTDVVLRGVISFVEKRKVERSKTKKEVSICKATDDDEKQNGSLGCVKKKKKGGKQKGKGKARSKEIPQDNCGFRLTEMFPSISNISLSPSSLFTAYASLTGFLMLFRSLFNDEVPERLRSYITDLLNRFFTPKSKNLTRNKIGPETARLRVGKLPKQKHFTIYIEKGEEILDTFENSELRWTYVESENEASQKEKRYYELTFEKKSYLSHVVAESEETKRDLRAVKGMAGAGWGCINLEHPSTFETLAMDPGAKKKIIDDMERFLKR--EFYKRVGKAWKRGYLLYGPPGTGKSSLIAAMAN--------KFDVFDQLKSILLS--TTNRSILVIEDIDQEYEEGYYGRVTLSGLLNFVDGLWSSFG-----DERIIVF-------TTNHKERLDPALLRPGRMDMHINM-SYCTGLGFRTLV-------SNYLGLGGLNHPLCEEIEALIDSTEVTPAELAE------ELMQEDDTDVVLRGVVSFVENRKVEISKTKELEGSTCRKLDGDDKHNVSSTNDLKKTKKKKKGG........................................................................................................................................................... |
989 |
| 47 | -9.850 | [A] KOG0344 ATP-dependent RNA helicase |
ali follow.. |
14 | 14 | ..................................................................................................................................................................................................................................................................................................................................................................................................................................QRESKLTSGKLENLRKEKINFLRNKHK--IHVQGTDLPDPIATFQQLDQEYKINSRLLQNILDAGFQ---MPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMKQPANKGFRALIISPRELASQIHRELIKISEGTGFRIH----HKAAVAAKKFGPKSSKKFDILVTTPN--------------------------------------------------RLIYLLKQDPPGIDLAS--VEWLVVDESDKL----------------------------------------------------------------------------FEDGKTGFRDQLASIFLACTSHKVRRAMFSA-----TFAYDVEQWCKLNLDNVISV-----------------------------------SIGARNSAVETVEQELLFVGSETGKLLAMRELVKKGFNPP---------------------------------------LVFVQSIERA----------KELFHELIYEGIN---VDVIHAERTQQQRDNTVHSFRAGKIWVLI-CTALLARGIDFKG-VNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFT--DDKPLLRSVANVIQQAGCPVPEYIKG........................................................................................................................................................................................................................................................ |
436 |
| 48 | -9.830 | [TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family |
ali follow.. |
8 | 893 | ....................................................................................................................KIKTIVGIEKMLSVKLGLPQILSNLQSAFQNEHLRFYAIKAWFSLILA---TKEPEYSSIAGEPQEAELVIQIFDFISSDTHKCLQGLKWAIPTSLDSACFSLKAKEIFCSLQNEDFYSELQSIIKCLTNENEPVCYLGLQKLELFFQAKVDELHDTLNL-----------DISNEVLDQLLRCLLDCCVKYASTNMQISY-LGELGAIDPSRAKAQHIIKET-DNFENGEESLKFILDFMQSQLIPAFLVTTDT-------------------KAQGFLAYALQEFLK----------------------GFKSAVINKKKGLTVVTEHWMSLPDLSKRVLIPFLTSKY---HLTPIPKIDIRYPIYKENVTIHTWMQLFSLKLMEYAHSQNAEKI-----FGICSKVVKDQEVNIPC---FLLP--------------FLVLNVILTESELEVNKVIEEFQL----------VINQPGPDGLNSVGQQRYTSFVDVFFKIVDYLNKWLRMRKKRNWDRRSAIARKENRYMSVEDATSRESSISKVRFPSKTLGIV----------------------SLNCGFHARALFYWEQHIRNATAPYAALESDYRVLQEIYAGID--DPDEIE--AVENSGTWDSALSCYEIIIQKDPENKKAKIGLLNSMLQSGHYESLVLSLDSFIIND-----------------------NHEYSKMLNLGIEASWRSLS---------DSLKKCLSKSNLESFEAKLGSIFYQYLRKDSFAELTERLQPLYVDAATA-----------------------------ANTGAHSAYDCYDILS-------KLHAINDFSRGIVSDNLDIVLRR--------RLSQVAPYGKFKHQILSTHLYEKFENTKKTAEEIARISRKGQFQRAFNAILKAMDLDKPLATIE----HAQWWWHQGQHRKAISELNFSLNNNMFDLVDEHEERPKNRKETLGNPLKGKVFLKKWLGKAGQLGLKDLETYYHKAVEIYSECENTHYYLGHHRVLMYEEEQKLPVNE-QSERFLSGELVTRIINEFGRSLYYGTNHIYESMPKL--LTLWLDFGAEELRLSKDDGEKYFREHIISSRKKSLELMNSNVCRLSMKIPQLSQMISRVCHPNNKVYKILEHIIANVV-ASYPGESTSQKRSLRGKSILNVLHSRKLSMSSK |
1969 |
| 49 | -9.670 | [A] KOG0333 U5 snRNP-like RNA helicase subunit |
ali follow.. |
12 | 323 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EPTPIQRQAIPIGLQNRDVIGVAETGSGKTAAFLL-------------PLLVWITSLPKMERQEHRDLGPYAIIMAPTR-ELAQQIEEETNKFGKLLGIKTVSVIGGA--------------REDQGMKLRMGVEVVIATPGRLLDVLENRYLLLNQ-------------------CTYVILDEADRMLDMGFEPDVQKVLEYMPDTNMK--------------------------KDTDEFDNEEALMKGFSTREKYRQTV-----FTATMSSAIERLA-------------RQYLRRPAVVHI-----------------------------------------------------GSAGKPTERVEQVVYMVPEDRKRKKLVEVLESQFQPP---------------------------------------IIFVNQKKGA----------DMLSKGLTKLGFKPTVL---HGGKGQDQREYALQALKEGTSDILV-ATDVAGRGIDVKD-VSLVLNYDMAKSIEDYTHRIGRTGRAGKHGKAITFLTPDDTAVYFDLKQVLVESPVSSCPP............................................................................................................................................................................................................................................................ |
702 |
| 50 | -9.650 | [L] KOG2108 3`-5` DNA helicase |
ali follow.. |
8 | 246 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SLNDRQRDAACSNISTPLMVIA--PGSGKGLLILAMTFTKAATSEMRERISAGKKAAKDITISTFHSF---LQLC---RMHADKLQRTSEFSVYGHGQQRRAIVRLYEEEKKNGSKTSVPCESGEGLNGAGAGAGKASGKSPEQCRKMGNEIGAKILGNYNDILKACDALDYHDL-WKAIIVDEFQQYKLLRMLGSHNHITIVGDDDQAQCAYVIDKIIEITNDGSTPCCSHGDIAILYRRQVSGKVFQNAFRQRKINVHGVAFYRK-QVILAMLKTTFSECDDASYRRVFKALLPFEKEEKKRIIEHIEKISTSRKCSFISAASDIFNAKISGTFKRSQLTQGRKVLQTLDMVAKLVDREQSLSAVVTCVANMIPQKYLLEQRAVVDNDGEDNDLRSVLQYLMDDVAEFISTHCTT------------------------TEEEDAIKEKKGCNQLHSFI-------NYISERETENFRSRRRD-----NENSVTLT---TIHQANENEIP--LLHESNGNASESGTSLEE-ERRLLYVAMTRARKKLFFLYVTVDSNWQGDMSVNDCRKVHENL........................................................................................................................................................................................................................................................... |
825 |
| 51 | -9.540 | [L] COG4098 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) |
ali follow.. |
14 | 92 | ......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RGQLTPFQEKVSEGLLKQKPTLVHAVTGAGKTEMIYQVVAKVINAG--GAVCLASPRDVCLELYKRLQQDFSCGIALLHGESEPYFRTP-------------VVATTHQLLKFYQ--------------------------------------------------------------AFDLLIVDEVDAFP---------------------VDNPMLYHAVKNSVKENGLRIFLTATSTNELDKKV--------------------------------------LGELKRLNLPRRFHGNP---------------------LIIPKPIWLSDFNRYLDKNRLSPKLKSYIEKQRKT----------------------------------------AYPLLIFASEIKKG---------------------------------------------EQLAEILQEQFPNEKIGFVS--SVTEDRLEQVQAFRDGELTILI-STTILERGVTFPCDVFVVEANHRLFTKSSLIQIGGRVGR-SMDRPTGDLLFFHDGLN------ASIKKAIKEIQMMNK......................................................................................................................................................................................................................................................... |
428 |
| 52 | -9.390 | [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits |
ali follow.. |
10 | 367 | ....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PGEYILDSSQLKAYQSMLTKRLSIIQGPPGTGKSFVTLKAIETLENTHSHVLPILVATNHAVDQILIRLLHQ--GASVMRLGSRTKDPEIAAVTIFQKA--------------KHTKHSFKAAYNEIRHKKQRLIKQITNIMHNFNLEFVTLSYLHSKGIITTSQLESLRNNSIWLGDAKVELITPSEITDGFEEELQIDPEKLEEIQKEAEDSGALMEEELRGKFINLRCKYLFSKLTTLHEKEIDTLLTIPNIWDIPEYSRGII--YCRWLESAYAAAEKELNRLYRFYLKVDRERIGFSNKRAAILLRG-ANVIGMTTTGLNKYRDILERINPKICFIEEAADVLEIIPAVFPSLEQL-GDHKQLRPGCSTYLRQDPFNLSISMFERLVENDME-TMQRRMHPQIRRLVSVYEDLSDYEIT-KYWPSIPGMGEIRRFFLTHSRIEDNDGSKINLFEQFAVYLINNGVEPQKITCLTFY--------------AAQKDLI---ERLLSESLNREKHFIKVATVD-----------------QGEEN-DVVLLSLVRNND---------RTEVGFLSSPHR-------------CVSLSRARRGLFIFGNAQLVAESN.................................................................................................................................................................................................................... |
949 |
| 53 | -9.260 | [A] KOG1804 RNA helicase |
ali follow.. |
13 | 309 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VLNENQKLAVKRILSGDCYILFGPPGTGKTVTIIEAVLQV-------------------------HFALPDSRILVCAPSNSAA---------------DLVCLRLHESKVLQPATMVRVNATCRFEEIVIDAVKPY---------------CRDGEDIWKASRFRIIITTCSSSGFTHVFVDEA---------------------GQASEPECLIPLGLMSDISGQ---IVLAGDPIKSRLAMAYGLNVSFLERLMSRPAYQRDENAFGACGAHNPLLVTKLVKNYRSHEALLMLPS-----RLF---------------------------------------YHRELEVCADPTVVTSLLGWEKLPKFHGVRGSEAREGKSPSWFNP-------AEAVQVLRYCCLLAHSISSQ--------------------------SASDIGVITPYRKIRILLRNVDLMDIKVGSVEEFQGQEYLVIIISTVRSNEDRFFLSNSKRFNVATRPKALLIVLGNRDPCFG............................................................................................................................................................................................................................................................................................................. |
724 |
| 54 | -9.230 | [A] KOG0338 ATP-dependent RNA helicase |
ali follow.. |
14 | 185 | .........................................................................................................................................................................................................................................................................................................................................................................................................................................KADTLKVKDRKKKKKKGQEAGGFFEDASQYDENLSFQDMNLSRPLLKAITAMGFKQP---------PIQKACIPVGLLGKDICACAATGTGKTAAFALPVLERPRQAPVTRVLVLVPRELGIQVHSVTRQLAQFCNITT------------------------CLAVGGLD--------------VKSQEAALRAAPDILIATPGRLIDHLHNCP------------------SFHLSSIEVLILDEADRMLDEYFEEQMKEI--------------------IRMCSHHRQTMLFSAT-MTDEVKDL--ASVSLK-----------------------------------------------------------------------------NPVRIFVNSNTDVAPFLRQEFIRIRPNR------------------EGDREAIVAALLTRTFTDHV--------------------------------------MLFTQTKKQA----------HRMHILLGLMGLQVGEL---HGNLSQTQRLEALRRFKDEQIDILV-ATDVAARGLDIEG-VKTVINFTMPNTIKHYVHRVGRTARAGRAGRSVSLV-----GEDERKMLKEIVKAAK--APVKARILPQDVILKFRDKIEKMEKDVYAVLQLEAEEKEMQQSEAQINT............................................................................................................................................................................................................. |
632 |
| 55 | -9.200 | [L] KOG1132 Helicase of the DEAD superfamily |
ali follow.. |
11 | 28 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QIGGLQVEFP-----YQPYGTQLAFMSRVISHCHALLESPTGTGKSLSLLCSVLAWQQ---ETQPSDTPASTNVEKAETATKKRTKIPTIYYASRTH---SQITQVIREYRKTGYRVPMAVLASRKHYCTNRHVLGKRGHNEVHDIEDLVKVGKNVR--ASWSMAENAQLVFCPYSYIVNPV------AGVEVDLIIFDEAHFFSMLLMLMIRPSTKSFTVHSNMEDIAREAELQNELEQDISLSVILTSGTPMNSFSSELGMQFGT----SLEAPHV---QVWAGAISNGPSNYPLNASYKTADAYSF-----QDALGKSLEEICTI---------VPG---------SLVFFPS----KLMEKLCMR-------------RETEQWSRLCLKKDLFVEPR-------GGAQDEFDSVLKGYYDSIRGKNKAGPIKTETQDDSKKGAAFLAVC-----RGKVSEGIDFADDNARAVVEDYTNSNPKY--------ESKAFGYHRDVKPKIAEDLRSM-----------SAQTFVQVK----------EEAECCREVIDLECG........................................................................................................................................................................................................................................................................................ |
704 |
| 56 | -9.010 | [A] KOG0343 RNA Helicase |
ali follow.. |
12 | 63 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KLTEIQADSIPVSLQGHDVLAAAKTGSGKTLAFLVPVIEKLYREKWTEALIISPRELAMQIYEVLTKIGSHTSFLVIGGKDVKFELER-------ISRINILIGTPG-----------------------------------------------------RILQHLDQAVGLNTSNLQMLVLDEADRCLDMGFKKTLDAI--------------------VSTLSPSRQTLLFSAT-QSQSVAD------------LARLSLTD-----------------------------------YKTVG---------------------------------------------THDVMDGSVNKEASTPETLQQFYIEVPLADKLDILFSFIK----SHLKCKM----------------------------------IVFL-------SSSKQVHFVYETFRKM-QPGIS---LMHLHGRQKQRARTETLDKFNRAQQVCLF-ATDVVARGIDFPA-VDWVVQVDCPEDVDTYIHRVGRCARYGKKGKSLIMLT---------------QEQEAFLKRLNARKIEPGKLNIKQSKKKSIKPQLQSLLFKDPELKYLGQ-KAFISYVRSIYVQKDKQVFKFDE............................................................................................................................................................................................ |
471 |
