current user: public

If you have questions about the server, please let us know.

Query: [KL] COG4646 DNA methylase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350    .  360    .  370    .  380    .  390    .  400    .  410    .  420    .  430    .  440    .  450    .  460    .  470    .  480    .  490    .  500    .  510    .  520    .  530    .  540    .  550    .  560    .  570    .  580    .  590    .  600    .  610    .  620    .  630    .  640    .  650    .  660    .  670    .  680    .  690    .  700    .  710    .  720    .  730    .  740    .  750    .  760    .  770    .  780    .  790    .  800    .  810    .  820    .  830    .  840    .  850    .  860    .  870    .  880    .  890    .  900    .  910    .  920    .  930    .  940    .  950    .  960    .  970    .  980    .  990    . 1000    . 1010    . 1020    . 1030    . 1040    . 1050    . 1060    . 1070    . 1080    . 1090    . 1100    . 1110    . 1120    . 1130    . 1140    . 1150    . 1160    . 1170    . 1180    . 1190    . 1200    . 1210    . 1220    . 1230    . 1240    . 1250    . 1260    . 1270    . 1280    . 1290    . 1300    . 1310    .
# Score Template Links and tools%idFirst VNRWFAQHPDFVLGTHALTSGPFGETYTCLAPDGEDLDAALSAAVHLFPEGRYDGEPTQIDLDLEDATDDSPRDLPAGRHVREGSFFVDNARGLMQVIDGEPVAVKVRKGRNADGIPEKHVRIIRKLISVRDAVRVVLKAQELDQPWKDLQVRLRIAWSSFVRDFGPINHTTVSITEDPETGKTRESHRRPNLQPFADDPDCWLVASIEDYDLENDTARPGPIFTDRVISPPAPPVITSAADALAVVLNERGHVDRDHIAELLHRDPEDVVTELGSAIFRDPADGSWQMADAYLSGHVREKLKVADAAAGLDPAYERNVSALTAVQPVDLRPSDITARLGAPWIPAGDVVAFVKEMMGTDIRIHHMPELASWTVEARQLSYLAAGTSEWGTDRRHAGELLSDALNSRVPQIFDTIRDGDSEKRVLNVVDTEAAKEKLHKIKQAFQRWIWSDPDRTDRLARVYNDRFNNIAPRKFNGDHLKLPGASGAFVLYGHQKRGIWRIISAGSTYLAHAVGAGKTMTMAASIMEQRRLGLVAKAMQVVPGHCLAQAAREFLALYPTARILVADETNFSKDKRARFLSRAATATWDAIIITHSAFRFIGVPAAFEQQMIHDELELYETLLLKVEDEDRVSRKRLERLKEGLQERLEALSTRKDDLLTIAEIGVDQIIVDEAQEFRKLSFATNMSTLKGVDPNGSQRAWDLYVKSRFIETINPGRALVLASGTPITNTLGEMFSVQRLMGHPALMERGLHEFDAWASTFGDTTTELELQPSRKYKPVSRFASFVNVPELIAMFRSFADVVMPADLREYVKVPAISTGRRQIVTSKPTQAFKHYQMVLAERIKAIEEREGPPQPGDDILLSVITDGRHAAIDLRLVDADNDNEADNKLNNLISNAFNIWKATEGSTYLRHDGKSFELTGAAQMIFSDLGTISVEKTRGFSAYRWIRDELIRLGVPASQIAFMQDFKKSEAKQRLFGDVRAGSVRFLIGSSETMGTGVNAQLRLKALHHLDVPWLPSQIEQREGRIVRQGNQHDEVDIFAYATEGSLDATMWQNNERKARFIAAALSGDTSIRRLEDLGEGQANQFAMAKAIASGDQRLMQKAGLEADIARLERLRAAHLDDQHAVRRQIRDAERYVESATRRIAEIGQDIERLVPTSGDAFSMTVMGKVYAERKEAGRALMKEILTQVQLQRQGEKVIASIGGFDLKYGGERFGRDGYRYTTMLMRTGADFEIDLAVTVTPLGAVSRLEHALGDFEGERERNRQRLADARRRLASYQSRDEGRDFAFAGELAEKLRQLAEVDAALATDVDERIAALast
1 -290.000[KL] COG4646 DNA methylase  ali  100  1VNRWFAQHPDFVLGTHALTSGPFGETYTCLAPDGEDLDAALSAAVHLFPEGRYDGEPTQIDLDLEDATDDSPRDLPAGRHVREGSFFVDNARGLMQVIDGEPVAVKVRKGRNADGIPEKHVRIIRKLISVRDAVRVVLKAQELDQPWKDLQVRLRIAWSSFVRDFGPINHTTVSITEDPETGKTRESHRRPNLQPFADDPDCWLVASIEDYDLENDTARPGPIFTDRVISPPAPPVITSAADALAVVLNERGHVDRDHIAELLHRDPEDVVTELGSAIFRDPADGSWQMADAYLSGHVREKLKVADAAAGLDPAYERNVSALTAVQPVDLRPSDITARLGAPWIPAGDVVAFVKEMMGTDIRIHHMPELASWTVEARQLSYLAAGTSEWGTDRRHAGELLSDALNSRVPQIFDTIRDGDSEKRVLNVVDTEAAKEKLHKIKQAFQRWIWSDPDRTDRLARVYNDRFNNIAPRKFNGDHLKLPGASGAFVLYGHQKRGIWRIISAGSTYLAHAVGAGKTMTMAASIMEQRRLGLVAKAMQVVPGHCLAQAAREFLALYPTARILVADETNFSKDKRARFLSRAATATWDAIIITHSAFRFIGVPAAFEQQMIHDELELYETLLLKVEDEDRVSRKRLERLKEGLQERLEALSTRKDDLLTIAEIGVDQIIVDEAQEFRKLSFATNMSTLKGVDPNGSQRAWDLYVKSRFIETINPGRALVLASGTPITNTLGEMFSVQRLMGHPALMERGLHEFDAWASTFGDTTTELELQPSRKYKPVSRFASFVNVPELIAMFRSFADVVMPADLREYVKVPAISTGRRQIVTSKPTQAFKHYQMVLAERIKAIEEREGPPQPGDDILLSVITDGRHAAIDLRLVDADNDNEADNKLNNLISNAFNIWKATEGSTYLRHDGKSFELTGAAQMIFSDLGTISVEKTRGFSAYRWIRDELIRLGVPASQIAFMQDFKKSEAKQRLFGDVRAGSVRFLIGSSETMGTGVNAQLRLKALHHLDVPWLPSQIEQREGRIVRQGNQHDEVDIFAYATEGSLDATMWQNNERKARFIAAALSGDTSIRRLEDLGEGQANQFAMAKAIASGDQRLMQKAGLEADIARLERLRAAHLDDQHAVRRQIRDAERYVESATRRIAEIGQDIERLVPTSGDAFSMTVMGKVYAERKEAGRALMKEILTQVQLQRQGEKVIASIGGFDLKYGGERFGRDGYRYTTMLMRTGADFEIDLAVTVTPLGAVSRLEHALGDFEGERERNRQRLADARRRLASYQSRDEGRDFAFAGELAEKLRQLAEVDAALATDVDERIAA 1315
2 -33.600[KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family  ali follow..  14  489........................................................................................................................................................................................................................................................................VEERKMLEEVFSGFIYDERDGAFRVKSEFMTETI-PANQHRITFNCPENLSGQFIYDETIFE-------SFREGSDINYYEADLKVHGLLKGVPLDLLWDCISAKKRFL-KAGQQSKGTRRGKVNSGKLPCILVLDLEKIAP---------------VQIFNEIGFKVLDDLVQKCPLWSLTGISLDQFEALPVNFSMSERLIEIQKQIRGEIEFDFQDVPQQIQLRSYQTEGVHERLRK-NGILADDMGLGKTLQAIIAVTQSKLEKGSGCSLIVCPTSLVYNWKEEFRKFNPEFRTLVIDG---VPSQRRKQLTALA--DRDVAITSYNLLQK--------------------------------------------------------DVELYKSFRFDYVVLDEAHHIKN-------------TTRNAKSVKMIQSDHRLI-----------LTGTPIENSLEELWSLFDFLMPGLLSSY-----DRFVGKYIRTGNYMGNKADNMVALKKKVSPFI---------------RMKEDVLKDLP-----PVSEILYHCHLTESQKELYQSYAASAKQELSRLVKQEGFERIHIHVLAT-KQICCHPAIFAKDAPEPGDSKYDMLMDLLSSLVDS-----------------GHKTVVFSQ--------------YTKMLG-IIKKDLESRGIPFVYLDGSTKNRLDLVNQFNEDPLLVFLISLKAGGTGLNLVGADTVIH-YDMWWNPAVENQATDRVHRIG-QSRSVSSYKLVTLNTIEEKILTLQNRKKSLVKKVINSDDEV--------VSKLTWEEVLELLQ.............................................................................................................................................................................................................................. 1165
3 -33.300[B] KOG0389 SNF2 family DNA-dependent ATPase  ali follow..  14  283...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LSSGLQLADYQIIGLNWLTQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAALIVVPSSTLDNWEAEISRWCPELVVEKYHGSQDERRRMRGRFAKDGFTGFDVLLTTYHI-----------------------------------------------------VGSTPEERKMFRVCKLDYVIFDEAHMLKN-------------------MTTQRYANLITINARMR----ILLTGTPLQNNLLELISLLCFVMPKFFAK----SIEDIKSLFAKKGKSDGDQDEVSQFQETQIQRAKRIPFVLR--------RLKKDVLKNLPKKL-----SLVEKVPMSSQQKIYYHELVDYYSNNKGEVC--SSSERAGIAIMMEMRRIANHPLLMRHYFTDANLRGFSKRLAN-FQVYQMMNKHEFYDVKIPDNLICDSGKFLYLDTLLPKLKAEGH--LFSQFTMMLVEEYLRIRKFGFCRDGATANVRQDLITDFNGDSIFVFLLSTKAGGVGINLTAADTCV--HDIDFNPYNDKQAEDRCHRMG-QQRPVTIYRLISESTIEEGILMAAEEKLKLEKDITSNEKGEVHEQRCVVKLLTT....................................................................................................................................................................................................................................... 819
4 -29.500[L] KOG1002 Nucleotide excision repair protein RAD16  ali follow..  13  136......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IMPLLRYQKEFLAWATKQEQSILADEMGMGKTIQAISLVLARRE--AAGCTLVLCPLVAVSQWLNEIARFTSPGSTKVLV---YHGAKRAKNIKEFM--NYDFVLTTYSTVES--VKTAKQSKQKRKKTSDSSSQQGKEADAGEDKKLKKSKKKTKQTVEKDQLGSDDKEKSLLHSVKWNRIILDEAHYIKE-------------RSNTARAVFALEATYRWA-----------LSGTPLQNRVGELYSLIRFLQIRPYSYYAVRHFCWWNKYVAKPITVYGSFGLGKRAMILLKHKVLKDILLRR---------TKLG----AADLALPPRIITLRRDTLDVKEFDYYESLYKNSQAE--EAGTLMNNYAHIFDLLTRLRQAVDHPYLVVYSNSSGTSTKIEALREEIRFMVERDGSAKAI------------------------------FSQFTSFLD-LINYTLGKCGVSCLVGSMTMAARDTAINKFKEDDCRVFLMSLKAGGVALN----LTVASHMDPWWNPAVERQAQDRIHRIG-QYKPIRVVRFIIENTVEERILRLQKKKELVFEGTVGGSQ--------EAIGKLTEEDMRFLFTT............................................................................................................................................................................................................................. 833
5 -28.500[KL] KOG0387 Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain)  ali follow..  15  276........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HLFRYQVTCVQWLWQEAGGIIGDEMGLGKTIQIVSFLSSLHHSGKFQKPLIVCPATLMKQWVNEFHTWWAPLRVVVLHATGSGQRASRE-------------------KRQYESDASESEAEESKTSIKLRGASSSFHRYAKNLVESVFTRGHILITTYAGLRIYGD---LILPREWGYCVLDEGHKIRN-------------------PDSEISISCKQIRTVNR----IILSGTPIQNNLTELWNLFDFVFPGRLGTL-----PVFQNQFALPINIGGYANASNVQVQTAYKCACMLRDLISPY------RMKLDVAADLP-----KKSEQVLFCKLTPLQRKAYQDFLQGSDMQKILNGKR-----QMLYGIDILRKICNHPDLVTREYLLHKSGKL-KVIRALLTLWKKQ----------------GHRTLLFSQT-----------QMLDILEIGLKD--LPDVHYCRMDGSTSIALRQDLVDNFNKEYFDVFLLTTRVGGLGVNLTGADRVI--FDPDWNPSTDAQARERAWRLG-QKKDVVVYRLMTAGTIEEKIYHRQIFKQFLTNKILKDPKQRRFFKMTDLHDLFTLGDNKTEGTETGSMFLGSERVLRKDNSSRNGNEAEDIPARDRKKHKIHDKG.................................................................................................................................................................................... 844
6 -20.600[R] KOG0354 DEAD-box like helicase  ali follow..  12  69.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................INVSFRDYQFNIVQKALFE-NVLVALPTGLGKTFIAAVVMMNYLRWFPKSYIVFMAPTPLVTQQMEACYKITGPKSQTAELSGHVPVTTRNQYYQS------NVFFVT--------------PQTILNDI--------------------------------------KHGICDRTRISC--LVIDEAHRVHLLSLSNKNFRILALSATPGNKLEAIQNVIDSLHISR------------IEIRTENSIDISQYVQKKEVDFFPVDRFSSILEPMLQKLNKGNYYRIQNAKDITSFTVVQAKQAFLAMSGQNFPANQKWDILNTFDALATFAYPLNLLLNHGIRPFYQKLREVEEECF-------VGRSGYKKRIINHENYRPLMDDIEILLRDQSFVGHPKLEHLERIVTEYFEKEQT-------------KDTRIMIFVEIRSSAEEILRFLGKFYPNVRPAIFIGQSAVR----AAGMSQKLQNETVKQFQKGEVNTLI-ATSIGEEGLDIGEVDMIICY-DASASPIRMLQRMGRTGRKRK-----YIYMLLTRGKEEAKWERAKDAYRTLQDNIVSGR....................................................................................................................................................................................................................................................... 572
7 -18.600[R] COG4889 Predicted helicase  ali follow..  14  6........................................................................................................................................................................................................................................................................................................DAVSALRTLPSQSAQGLAFEKLMVNFIKSDPT------LSTEFDEVHRWVDWPYNGGTMDTGIDLVAYNKDDDAYTAIQCKFYLPTTSLAKGQLDSFFEASGRTFETPEGTRLVISTTDKWSSNAEKMLENQTIPTNRIGLSAIAESPIDWDIAYPGSELTINLQ----------------------LKEPYSPRPHQQTAIEKAIEHDRGKLIMACGTGKTFTALRLSEEVRLNGNKARILFLVPSSLLSQTLKEWTA--DLRPVAVCSDSKVSKAAEDIAAYDLE----------------VPVSTD----------ALIAEKLEHRKRAAGLTV------VFSTYQSLPAVHAAQEAGAE-----FDLVICDEAHR-------TTGITLAGEDPSNFTRIHD--------ASYIKAAKRLYMTATP------------RLFDDSVKGKAAVSSMDD-EAIYGPEFHRLGFGEA---------------KGLLTDYKVVVMTVDEQVAASALTVLGSTPGEE--LTLDMTSAIIGAWNGLAKRSGKEQDTKTGFSSSDAAMERAVAFARDIK-------------TSQQIAESFPRVVNAYTTELEVKNDDVDEHNLNLS---------------------------------------ACQHVDGSMNALERNSRLTWLKASMETKILTNARCLSEGVDVPA-LDSVIFFNPRNSMVDVVQSVGRVMRKGKNYGYIILPVAVPPGV.............................................................................................................................................................................................................................................................................. 619
8 -17.000[R] COG1202 Superfamily II helicase, archaea-specific  ali follow..  13  216........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ELLPVQVLAIKNGLLKGNLLVVSATASGKTLIGELAGI--PKALEGKKMLFLVPVALANQKYEDFKRRYSKLGLKVAIRVMSRIKTREEPVVVDTGIDADIIVGTYEGVDYLLRSGKKIGN-------------------------------------------------------VGTVVIDEIHMI-----------------DDEERGPRLDGLIARLRKLYPKAQFIGLSAT-VGN---------------------PQELARSLGMK----------------------------------------------------------------------------------------------------LVLYDERPVDLERHLIIARNESEKWRIIAKLCKAEVMRKSSKGFKGQT--------------IVFTYS-----------KRCHELASFLTGKGL---KAKPYHSGLPYKQRKITEMEFQAQMIDVVV-TTAALGAGVDFPASQVIFESLNKWLSVREFHQMLGRAGRPLYHEKGKVYLIVEPGKKYSAQMDETEDEVALKLLTSPIEPVIVEWSDEIEEDNVLAHACVFNRLSVIEEVNSLTLAKKVLEKLEELGMVSIRGDIVRVTPYGRAVSMSFLLPSEGEFIRENLESMDP................................................................................................................................................................ 669
9 -16.700[R] COG1203 Predicted helicases  ali follow..  13  12.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HSPYEYQKEAMDNLLEGKSLIIRAPTGAGKTEASLIPFIYGLNDYLPPQLIYSLPRTLVESIGERAIKYASFKKL--------------------------RVAIHHGK----ATSSLFEEDIIVTTIDQTAGAY-----------------------SVPLSMPKRWGNIFVGGIASALTVFDEVHTL------------------DPEKGLQTAAAIAMQSAKLGLP-SIIMSAT--------------------LPDVFIERVKERIEKNGGKVEIMDVKNESEIKSRRN----------------------------------------RKVELINRPDEMLTADTVLKEAE-----------NCRKLVVVVNTVERAQ---------------------------------------------------------------------NLYLDLRKKI------DYPIFLLHSRYLEKDRAEKEKSFKNGKGECIFISTQVIEVGMDISSPIILSE------APIDLIQRAGRCARWGGNG-EFHVFGLARDSSNPYAPYELIESTITEIRSKGDFPLDWQTELQLVNNV---LSSHFEFFMDSKFFYQRLG--------ELARAVYEGSKAKVEQNVREIFS..................................................................................................................................................................................... 434
10 -16.500[LK] COG1200 RecG-like helicase  ali follow..  16  267.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FQPTNAQKRVVSDIEQD-MRLVQGDVGSGKTLVAALAALTAIDNGK--QVALMAPTEILEQHANNFRRWFKPFGIEVG-AGKVKGKSRQAELEKIKTGAVQMVVGTHALFQ---------------------------------------------------------EEVEFSDLAL--VIIDEQHRF------------------GVHQRLMLREK----EKAGFYPHQLIMTATPIPRTLA-------------------------MTVYADLTSIIDELPPGRTPITTVVVSEERRAEIVMRVKN----------------------------------------------------------------ACVNEKRQAYWVCTLIDES---------------------------------------------------EVLEAQAAEAIWEDLTKAL-----PMLNIGLVHGRMKPQEKQDVMMRFKNAELDLLV-ATTVIEVGVDVPNASLMIIENAERLGLSQLHQLRGRVGRGCTASFCVLMYK-VLRDSQDGFVISEKDLEIRVLGTKQTGIAELRVANLMRDRKMIPTVQHYALIQKYPDVAES...................................................................................................................................................................................................................... 678
11 -16.400[KL] COG1061 DNA or RNA helicases of superfamily II  ali follow..  13  9........................................................................................................................................................................................................................................................................................................................................................................................................................................YDRGTLILHPPPRGKAWMDYATWFRIPAMRYRAVVEALQAEDVFFIDEAKQFYPIDLV-PSLEMEPYPHQSEALAAWKLAGQGVVVLPTAAGKTYLAQLAMQATPR-----TTLIVVPTDLMHQWYAHLVAAFPDAEVGLLGGGSRDKSP---------------VLVA--------------------------------------TYDSAAIHAEALGNQY------------------ALIVFDECHHSKVIAEYAIAPYRLGL------------------------------SATPERTDGKH---------------------ADLNILIGQEVYRKRAEDL----AGKALAEHEIVQIKVKL---------------------------------SQQERERYNNLIQIRNDFLRQSKVSLGSIQGWQMFVQMSARSQSGRRAMLAHREAKEIALGTDSKLRILANLLAKHYPER----------------LIFTA----------DNATVYKISQDL--------LIPAITHQTPVKERHEILTKFREGEYNTLV-ASHVLNEGVDVPAAAIAI--LSGTGSTREYIQRLGRILRKGIQNKQAILYEVIAEDTTSARRRGEDKKANLQVVYGSGKGTTAKAAEQIEINYVVDNSSANNQGNATNGTPQPSPKRRRNNTKKTED........................................................................................................................................................................................................ 517
12 -16.300[A] KOG0349 Putative DEAD-box RNA helicase DDX1  ali follow..  11  24........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LPTDIQAESIPLILGGGDVLMAAETGSGKTGAVIQIVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSR-------EVKEWHGCRATKGLMGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDIDKGHVKFSKNGMKNQALFPACVLKNAELKFNFGEEEFKFPPKDGQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVST-LNLSQVRFLVLDEADGLLSNRMHNQIPQVTSDGKRLQVIVCSATFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKID-----------DNLEQYFIQQGGGPDSCVCLHGDRKPHERKQNLERFKKGDVRFLI-CTDVAARGIDIHG-VPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWGCTIWQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQ-KRAAGGGSYKGHVDILAPTVQELAALEKEAQTSFLHLGYLPNQL....................................................................................................................................................................................... 736
13 -16.000[L] COG1198 Primosomal protein N` (replication factor Y) - superfamily II helicase  ali follow..  15  257....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SRPLELNPEQRQARDAVVSSPPFLLQGITGSGKTEVYLQIIQGALDKG--KTAILLVPESLTPQMTERFIARFGDK--VAILHSGLSNGEKYDEWRKVERGDAQVVVGARSAI------------------------------------------------------------APLKNLGV--MIIDEEHEYKQ-------------DSNPRYHAREVAI----LRAQYNQATLVLGSATP--------------------------SLESRARAGKGVYQHLRLT--------QRANPLATIPEV-----QVIDFRD-----------YIGQNETSNFTPPLLEAIQDRL-----------------VKKEQVVLMLNRRGYSSFVMCR-----------GTVDTCPNDISLTLHMDTKTMNCHYCGFSKDIPKSRSIRYYGTGTQKAYDE-------------LAELFPQARILRM-DVDTTRKKQALLDQFGRGEADILLG-TQMIAKGLDFPNTLVGVLNADTDFRSSELTQRSGRAEKAGQVNPQHYAIRFAKDQDYEGFYAYEMGIRRQLYYFTIGITLSHKKEEEVFKRAYEVMNILRSGLSETSPIL---PTPKPIARTHNLYHYQILIKYRLEDELGSTLNQV................................................................................................................................................................................... 774
14 -15.900[V] COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases  ali follow..  11  96................................................................................................................................NILSVFHKL-AVHEYHNDLNDAQMCLRLGFR-YYRLVTKDYDFPVPVFVLPERGENLYHQEVLTLKQQLEQQVREKAQTQAEVEAQQQKLVALN--GYIAILEGKQQETEAQTQARLAALEAQLAEKNAELAKQTEQERKAYHKEITDQAIKRTLNLSEEESRFLIDAQLRKAGWQADSKTLRFSKGARPEPGVNKAIAEWPTGKDETGNQGFA--------DYVLFVGLKPIAV----------VEAKRNNIDVPARLNESYRYSKCFD-VHEAVPEYETSWQDTSGKQRFKIPFCYSTNGREYRATMKTKSGIWYRDVRDTRNMSKALPEWHRPE----SEPQKQNQWFADNPGMSELGLRYYQEDAVRAVEKQQEILLAMATGTGKTRTAIAMMFRLIQSQRFKRILFLV-RSLGEQALGAFEDTRINGDTFN------SIFDIKGLTDKFPEDSTKIHVATVQSL----------------------------------------------------VKRTLQSDEPMPVARYDCIVVDEAHRGYILDKEQTEGELQ------FRSQLDYVSAYRRILDHFDA--KIALTATPALHT---------------------------VQIFGEPVYRYTYR------------------------TAVIDGFLID---------------PIQIITRNAQEGVYLSKGEQVERISPQGEVINDTLEDDQDFEVADFNRGLVIP-------------AFNRAVCNELTNYLDPTGSQK---------------TLVFC------VTNAHADMVVEELRAAFKKKHDAIIKITG-DADKDARKVQTMITRFNKERLPNIVVTVDLLTTGVDIPSNIVFLRKVR---SRILYEQMKGRATRLCPEVNKTSFK-------FDCVIYSTLESVDTMRPVVVRPKVELQTLVN--EITDSETYKITEADGRSFAEHSHEQLVAKLQRIIGLATFNRDRSETIDKQVRRLDELCQDAAGV............................................................................................................................................................................. 955
15 -15.600[L] COG1111 ERCC4-like helicases  ali follow..  12  13.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EKIEARTYQQLLAADVIRKGNSMIVAPTALGKTVVAVLVAAERLRKYRGSKVLILSPSPLAIQHEESFREFMLATCTSLTG--SIKPEERKERWI-----KSQIISATPQTV-----------------ESDILAGRYDLRD-------------------------------------VSLIVFDECHRASNYIQNARHPLILGLTASPGADEDKIKTVCENLFMNE------------VVVKTEGDPDVRPYLKPIKIEWVKVRMTPELEDIRELLRKVLKNRLKMLKNLGVIDTISVGKKDLLKARGRVQNRIARSTSPPRACYRAISLLASCINVEHALELLETQIRPLHQYLLRLKEKKTKAAKG------LLADPDFTRAMHLTRRAMMSGVEHPKLDRLMEILKRELKGDEAR-----------------IVFTQF-----------DTLEEIYQRCKREGINAVKFY--EKGLTQKQQRDIIKSFRMGNHDVLL-STSVAEEGIDIPSVDLVVMY-EPVPSEIRMIQRRGRTGRKRK-----RMVVLITEKTRDEAYYYSSIRKERSMKENLRG........................................................................................................................................................................................................................................................ 500
16 -15.100[KL] KOG1123 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 3`-5` helicase subunit SSL2  ali follow..  13  326...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LKPAAVLRPYQEKSLRKMFGNGRAVIVLPCGAGKSLVGVTACCTVRK-----RALVLCNSVSVEQWKQQFKMWSTADDSMICR---FTSEAKD------KPMGCGILVTTYSMITHTQKRSWEAEQTMRW----------------------------------------------LQEQEWGIMVLDEVHTFRRVLTIVQSHCKLGL------------------------------TATLLDDKIADLNFL-----------------------IGPKLYEANWL----------------------------ELQKKGYI-----------------------ARVQCAEVWCPMSPEFYREYLTTKTSKKMLLYVMNPSKFRSCQFLI-------------------------------------KYHEQRGDKTIVFSD----------NVFALKHYAIKM--------NKPFIYGPTSQNERIQILQNFKFNSKVNTIFVSKVADTSFDLPE-ANVLIQISSHGGRRQEAQRLGRILRAKKGAIAEEYNAFFYT-SQDTMEMSYSRKRQRFLVNQGYSYKVITHLKGMDTDSDLMYGTLQLVLSASDLDCEDEKLPGEPGYRPSGSGGAVRRVGGLS............................................................................................................................................................................................. 768
17 -14.600[S] COG3421 Uncharacterized protein conserved in bacteria  ali follow..  10  50....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NLKYPFFEWQKSALENFVI-THLLFNMATGAGKTMMMAALILYYFEKGY-RHFLFFVNQNIVDKTENNFIDPAHAKFLFTEKILQGDTVIPIRKVEMFSPHSDGIEIK-----------------------------------------------FTSIQKLYNDIHTERENQTTLADL--LVMLGDEAHHLNAQTKGKKQDELDLEAEIERKGWEHMVLELLLNKNGNPGQNVLLFTATLPENAIITKFGLKEFLQKGYTKEINLVSSTL--------------------NKKERVLHALLFAWYRHQIALKYGIANFKPV--------------MLFRSKTIDESKADYSAFLNWAENVQADDFEFLDTFSGSLNNSDNANEQGKTRTEQALKFMQDNKFGFAHLANWVKQNYQKHN-----------------------------------IITNSETNKNK--------------TEKTDSETEKLLNNLEANPIRAIF-TVDRLTEGWDVLNDIVRLYE-----KTAAEKQLIGRGVRKQPNKRKFDNDMQHELRILEELFYYTHDEQSRYISELKNELRKDGYLPEKDDDKVLATFKLKSEFADNKDFRELLIWANKKIPNPNAKSNNADSLQANPQTLS......................................................................................................................................................................................... 625
18 -14.300[A] KOG0348 ATP-dependent RNA helicase  ali follow..  13  52........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................APTLVQAQAIPVILSGRDVLVNAPTGTGKTIAYLA----------------------------------PLIHHLQGHSPKVDRSH--------------ALVIVPT--RELCLQVYETLEKLLHRFHWIVPGYVMGGEKKAKEKARLRKGISILIATPGRLLDHLKNTASFVHKNLRWVIFDEADSILELGYGKEIEQIIKLLGSGQNEQGE-----DDIVPKGIQKQNLLLSAT-LNDKVNDL----------------------------------------------------------------AKLSLDDPVMIGLDNTKLQQNLSIESPAAPDSDAEDMVIHVNKSANPLSEDYGIPSQLVQRYLRVPCGARLVAL-LSVLKNLFEREASQKV----------------------------------VVFFST-----------DAVDFHYSLLSEFQWPPNKTFRLHGSMEQEDRRSAFGTFKTEKQAVLL-STDVAARGLDFPK-VRCIIQYDCPGEATEYVHRVGRTARIGEKGEALLF---------------LQPIEIDYLKELKKHGASLTEYPLMKVLDKFPIPGNMPRIKKVLSLESHPWVISLQRALESLTYAEPKMKSLAKNAFVSWVRGYAAHKGELKSI......................................................................................................................................................................... 546
19 -14.300[L] COG4581 Superfamily II RNA helicase  ali follow..  15  279.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FELDNFQKEAIYHLEMGDSVFVAAHTSAGKTVVAIALAQKHMTKAIYTSPIKALSN----QKFRDFKHKFEDVGIL--------------------TGD-------------VQVNPEGSCLLMTTEI-------------------------------LRSMLYRGADLIR----DVEFVIFDEVHYVNDLERGVVWEEV-------------IIMLPPHVT-------LILLSAT-VPNT---------------------KEFASWVGRTKKKNIYVISTLKRPVPLEHYLWVKQNMFKIVDQHGRFLMDGYKSANDA-LKKPDKPVIAKDNKNSARGRGAARGRGVQTNMMRGRGSAKSVERRDANTWVHLIGHLHKQNLLPVIV-------SKKRCEEYVDTLTNR------------DLNNHQEKSEVHVVIEKAVARLKKEDRLLPQIGRMRE-MLSRGLAVH-----HGGLLPIIKEIVEILFQRGLVKVLF-ATETFAMGVNMPAKSVVFSGTQ---LPGEYTQCSGRAGRRG----------------LDVTGTVIILSRSELPDTASLRHMIMGPSSKLISQFRLTYNMIL-----NLLRVETLRIEDMIKR----------SENVNQTLVPQHEEKIKSFEEKLSALKK....................................................................................................................................................................... 782
20 -14.100[R] COG1201 Lhr-like helicases  ali follow..  13  25........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RPTEPQERAFPHILDGKHTLLIAPTGSGKTESAVLPVFNA----ILKKKLYITPRALNRDMLSRIEVMGKLLDIKVQVRHDTPQSERQRQSRN------DLLITTPETLQAMFSGSRLRKNM-----------------------------------------------------TVTHVVVDEIHEL-----------------ASSKRGAQLAIGLERLVEISGEFQRIGLSAT-----VGNPWEIAKFLAGANRDFTVIE----------------------------------------------VALLKLLEFDVISPQVSGEAEDREVMEIARTVGCEPEFASHLSLIRKI---------EESQSTLIFVNTRQSA------------------------------------------------------------------------EALAAGFRKLG---ASIGVHHGSLSFEARVEAEEAFKAGALRGLI-CTSSMELGIDIGN-VDRVVQYGSPRQVSRLLQRVGR---AGHRLHEVSRGTVLSMEADD------TAESMAITKAALEGRVEDISPHVNSLDVVANQIAGMVMDFGE------VGIEKIFRILRRAYPFRDLRPEELQRVVDQIGDYRLVWHEKGSQIVKKRRKSWQYYYDNLSMIPDEKKYEIYDIVGGRSIGVLDEAFVVNFAEPGAVFITKGDMWRVIEMPDREREPSRDRIKVEPVEGMGEVPSWTGEEIPVPFEVAQDVGKLRAEIAALLRDGLEDEAVAEKLRLKYPVSRSAVLELIRLIRDQVEG............... 619
21 -13.500[V] COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases  ali follow..  10  7..........................................................................................................................................................................................................................................................................EAALIKKLETEGWTYREDLSNV-SIKKLEEHWRDILNET------------NAHKLNGVPLSEIEFGLILQELQRI--TPYDAQLLLVGAGGVGSIPITRDDGSSLEVEIFYEDDVAGGRSRYGLTTKRIIDVA--LINGIPVVHIEKDEHLQNQWRAFEQLKGYHGDGLYKGLFEQYNKT--ENNKDITDAFEFIHQVMSIPALHRLVTVNMIPDASNDNIMVRSYQIQATREILQKEGGYIWHTTGSGKTVTSFKVAQLLASAPRIKNVLFIVDRIDLIQTLENFKSF-------AHFKNRIKKVNGRELKRELKRKGSSQILLI---------------------------------------------SVQGLTKAVKKGLENDDWNV---------IIMDEAHR-------SASGESV-----------------KLIKKALKKTTWFGFTGTPNFYS----------------------------------DEINDVKTTREISTHDIFGKRLHTYTIKD---------------------AIGDGNVLGFDVTYFKPHWVVEHPQEDFSEKDYEKEVYQSDVYRQEVVKDILDNWTKTSSGALIAGKREENAFQAMFAVSGKQAAVNYYNIFKSKGSHLNVAMTFSRDESNEHGTKEQNEALKIAIKDYTEKFNVPSILDAKDPARAYMLDITKRLARKRPYNGKEKDRLDLVI--SDQLLTGFDSK--FINVIYMDKMLKEGMLIQAISRTNRDLNSKPHGKVRFYRQGDEMREFVENALRIYTR-----GGNDTLQEAEEETKNQLPKDLENDDILAKP--QSHQINELEEAVLRLKELAGDDFSQVPRGQNDLKEFVGLALTTQTRIQQLIQQGYELGSEIEEGRMVRLNISSIDEFGALQARLYDAKEKLPPEERPDLTEI-GIEFYHHEIIDYDMLVELLNTFMDEKNKSNKDAIEKHIVPMDEESQHEIHGIVDDIEAGNITEHFTTDSLQETRKKYRTEHRELKVRRAANQKVNGNRIVEAFDLFLPGHTLIDNP 961
22 -13.400[A] KOG0350 DEAD-box ATP-dependent RNA helicase  ali follow..  11  99................................................................................................................................................................................................................................................................................................................................................................................................................................................SKPHVKNITSVLPKWLAEPITVDPNTTVEFSSLISSKLVERLQKQNIT--------RGFAVQAAVLPLLLQDGDVCVSAATGSGKTLSYVIPIVQSHRTVPRLRCVVIVPRELTVQVAKTFEYYMSGAGLAWTGQKSLRHETYQ-LNGDENECRIDVLVSTPGRL------------------------VDHIRNDESFSLQHLR-----------------------------YMVIDEADRLLDQSFQDWVDTVMEISHPKCLQNKSNILDLDQNISPTFLPDIDTLLPYRLPSPLQKLV---------------------FSATLTRDPSKIA-------------SLKLHNPRLVLVQNKDMEVDDGGEIEDDAIVFSVPPTLQEYHVSVSSEKPILLYHLIHSK-------------NLTNILCFVKSNEAAARLHRLL-------------------------------------------------------------------ELIHESLNQSFSCGLF---TSSLSRDERKKIISRFATGDLNLLV-CSDLMARGIDVAN-TQNVINYDPPLSVRSYVHRIGRTARAGREGFAWTLVQ-------EGHHFSKLVKQLRRTLPIKRIKIEFSHISE............................................................................................................................................................................................................................................... 574
23 -13.200[LK] COG1197 Transcription-repair coupling factor (superfamily II helicase)  ali follow..  15  550............................................................................................................................................................................................................................................................................................................................................................................................................................................................EAWAKSRQKAAEKIRDVAAELLDVYAQREAKKGFAFKYDRE-PFEETYDQEMAINAVISD-DRLVCGDVGFGKTEVAMRAAFLAVMNH--KQVAVLVPTTLLQQHYENFKDRFANLPVNVEVLSRFTAKEQKQILENLAEGKVDILIGTHKLIQS----------------------------------------------------------VKFNDLGL--LIIDEEHRF-------------GVGQK------------EKIKQLRANIDILTLTATPIPRTL-------------NMAMNGIRDL-----------SIISTPPARRLSIKTFVRQNDD----------------------------------------------LVVREAILR-------------------EILRGGQVYYLHNDV----------ASIENTAEKLTAL-------------------------------------------------------VPEARVIVGHGQMRERELERVMSDFYHQRYNVLV-CSTIIETGIDVPTNTIIIERAD-----AQLHQLRGRVGRSHHQ----------------AYAYLLTPPPKMMTKDAERRLDALENLDNLGAGFILATHDLEIRGAGELLGNEQSGLDAAVKALKEGREPSLEELTQQQADIE--DDYLGDVNMRLSFYKRIAAAESKAELDELKVELIDR................................................................................................................................................... 1051
24 -12.800[L] COG1110 Reverse gyrase  ali follow..  14  63...............................................................................................................................................................................................................................................................................................................................................................................................................................................................LYRLNKEVSEVEDLFKRATGF--------------------RFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYFAIKG--KRSYIVVPTTLVVQTVKKIQDMMERAGVLVYYHGNLKKKEKEEALKRIKDGDFDILVTS--------------SQFLATRFDEL-----------------------------------------LRDKRFDLIFVDDVDAFKASKNIDRSLLLLGFTQEVINRAWEV------------------------------------------------------------------------IKLKKQLAKLLQ-------------------------------------AQGKEKEVEELNKEIEKIEREIERYRRENNIGI--LIVASATGSARGDRIKLYRELLGFEVGSGRSV-LRNIVDTYIIPERSIEEEVENLLRKLKGGLIFVPIDKGIEFAE---------ELTNYLKSKGFKVELVS--------AKNKRGLELFERGEVDYLVGVATYYGTGLDLPHLIRFAVFAGVPKFRFSMDLEQ-RLIRNIPQYELMKIEEALAEGGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVEGKLYIEIPD--VRTYIQASGRTSRLSVIIVDDQKVFNGLIRQMRWRFVEFEIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSAL------MIVESPNKARTIASFFG................................................................................................................ 658
25 -12.800[R] COG1204 Superfamily II helicase  ali follow..  931................................................................................................................................QFMRRLADCLNAEVSLGTVRSIEDGVD--WLGYTYLYVRMLRSPALYSVGPEYDDD------KYLVQKRADLLHSAAILLEKYNRQSGTLTATELGKVAASYYVTHNSMAIYNRLLMQTTSFIELFRVEFKHIPVREEEKVELAKLLERVLDEPAAKINALLQSYIS---RQRLDGFALVADMVYVTQSAGRIMRAI---------FEISLRRGWSSVATLSLDTCKMIEKRLWPTMSPLRQFPNCPSEVIRRVEKKEFPW-GVPKEGRRVYNMVQSFPRLSVEAHVQPITRSLVRVELVINSQFNWDDHLSGTSEAFWILVEDVDGDRLLHYEQFFLLSLNNPSFISLYPNFKFFNK-------QTQVFNSVYTNDSVFIGAPNGSGKTVCAELALLHHWSQEDYGTAVYIAPQEIVDRRYEEWYGKFSDLGDGKVLVK--------------LTGERSQDLKLIQVADLIFCTPS----------------------------------------QWDSLSKRWRSMRSIQKVDF--YICDELQ----------------LGGFYGPLYEIVISRIRYMAVQLEKNIRVVGLSVSVANA------LGEWLG---TSPQCIFNFSP------------------KDRPNPLTIHLQSFSITHFPSL----MLAMSKPIYRSLKNFISQRKSTIVFTPDRKVAKQLAFDLVTFSMA--------DEDEYLFSLMENEAFNKVEDAAL-----------------------------------------------------------------------QQSLKHG-----IAYISEITSSNDQNIVQYLYRHGLIKVLI-ASRDVIYSLKAKSNAVIVMGTQYDYPISELLQMLGFTASISELSQVILMTVTTKKEYYKKFLNEPLPMESHLQVWLFVSEISTQTIESKQDAVDLTWSYMYRRLVANPAYITHESVSEFLSDL............................................................................................................................................................................................................ 1823
26 -11.900[A] KOG0347 RNA helicase  ali follow..  12  213........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EPTKIQKACFNVAAYQGKDVIG-ETGSGKTLAFGLPILQRYAADGYLRALIITPRELALQVTEHLENAAKNLSVKVVP--GMFSEKQERRLKE------EIVVATPGRL-------------------------------------------------WELMSAGEKHLVELHS--LSFFVLDEADRMVERGHFRELQSILDLLPVTDKPNEG--------TQTVKSNDTVLNVPKKKRQTFV------------------------FSATIALSSDFRKKLKRGSSKSKQSSSGEVNSIEVLSERAGMRD-------------------NVAIIDLTTTSILAPKIEE--------------------SFIKCEEKEKDAYL-YYILSVHGQ--------------------------------------GRTIVFCTS-----------TDLRHISGLLKILGLDVCTL---FSEMKQRARLKSIDRFRASENGILI-ATDLVARGIDIKN-VRTIIHYKLPHSAEVYVHRCGRTARAFADGCSIALIE--LCKSFSMESVKIFPLDNSYMPAVRKRLYLARQIYEIERKGSRENADRTWLKK----HAESMELELDDEESEEERVDNVRQRKATSARLNKLKEELSTLLSH............................................................................................................................................................................. 714
27 -11.500[A] KOG0331 ATP-dependent RNA helicase  ali follow..  13  52.........................................................................................................................................................................................................................................................................................................................................................................................................................................................PKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPNFPANVEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIHQPFLERGDGPICLV--------------LAPTRELAQQVQQVAAEYCRACRLKSTCI------------YGGAPKG---------PQIRDLERGVEICIATPGRLIDFLECGKTNLRR-------------------TTYLVLDEADRMLDMGFEPQIRKI--------------------VDQIRPDRQTLMWSAT-----------------PKEVRQLA----------------------------------------------------------------------------------EDFLK---------------------DYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKT----------------IVFVETKRRC----------DELTRKMRRDGWP---AMGIHGDKSQQERDWVLNEFKHGKAPILI-ATDVASRGLDVED-VKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFT--NNIKQVSDLISVLREANQAINP............................................................................................................................................................................................................................................................ 469
28 -11.400[A] KOG0341 DEAD-box protein abstrakt  ali follow..  12  7........................................................................................................................................................................................................................................................................................................................................................EADSYIEYVSVAERRAIAAQKILQRKGKASELEEEADKEKLAEAKPSLLVQATQLKRDVPEVSATEQIILQEKEMMEHLSDKKTLMSVRELAKGITYTEPLLTGWKPPLHIRKMSSKQRDLIRKQWHIIVNGDDIPPPKFPRPVQPTPIQVQGLPVILAGRDMIGIAFTGSGKTLVFVL-------------PMIM---IALQEEMMMPIA--PIGLIVCPS---------RELARQTYEV---VAPLVEAGYPPLRSLLCIGGIDMRSQLEVVKRGVHIVVATPGRLKDMLAKKKMSLDA-------------------CRYLTLDEADRLVDLGFEDDIREV--------------------FDHFKSQRQTLLFSAT-----------------PTKIQIFARSALVKPVTVNVGRAGAANLDVIQEVEYVKQEAKIVYLLECLQ--------------------------------------------------------------KTSPPVLIFCENKADV------------------------------------------------------------------------DDIHEYLLLKGVEAVAI---HGGKDQEDREYAISSFKAGKKDVLV-ATDVASKGLDFPD-IQHVINYDMPAEIENYVHRIGRTGRCGKTGIATTFINKNQSETTLLDLKHLLQEAKQRIPPVLAE........................................................................................................................................................................................................................................................ 530
29 -11.300[U] COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase)  ali follow..  12  2............................................................................................................................................................................................................................................................................................................................................................................................................LGFAKKLFGSSNERKVKTLATRVAKINAYEAEYAALSDEALKGKTAEFKARLEKGETLDDILNEAF---------------AVVREASKRVLGMRHFDVQMVGGMVLHFSGISEMRTGEGKTLVATLPTY-LNALEGKGVHVITVNDYLARRDADWMGQVYNFLGLSYVIVNGLSQGERQRAYRS------DITYGTNNEFG----------DYLRD----------------------------NLVYSVDEMVQRGHNFAIVDE--VDSILIDEART------------ISGPTEDRSSFYKTIDVLVKELILDKSM------------------FDHDEKQKQVILTEDGQEKIEEILMSYDAANVSVVHHVNQALRANILYTR-----DKDYIVKGGEVVLIDEFTGRMMTGRRLSEGLHQAIEAKEGADIQP-IQNYFRLYKKLSGMTGTASTEAQEFMSVSEIPTNRTIQRIDDDDEVYRTEREKNEAILKQIADCHVRGQP-----------------------VGTVSIEKSEELSKLSFEKDGKKVKGIPHQVL----NARFHEQEAVIVA--DAGVPGAVTIATNMAGRGTDIQLAAGGLFVLGTERHES--NQLRGRTGRQGDPGREDDLLRIFAGERLDAIMRTFGVQEGEAITHKWLNNAIATAQKRVEQR---NYEIRKNLLKYDDVVNDQRKA................................................................................................................................................................................................................... 670
30 -11.200[R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster  ali follow..  7....................................................................................................................................................................................................................................................................................................................................................................................................................................................SRQVADSVAAFLLNSPLFNGENNDNVSMLEQFLAQPELKGPYLSFPNLTLPFPPHAHQARAFQRLGSDAPTLVATGTGSGKTFPLLNHCAGASQAGV--KAIIIYPNALATDQASRFAKTFVGDS---EIEPSKKMSAEKVITCKLRESPPDILLTNYKMLDYLLMRPGDQPLWRYNQPGSLR-----------------------------------------------YLVVDELHTFD------------------GAQGSDLACLVRRLKHHIGQRFACVGTSATVGDELGQLLDYAKTIFDQPFTDDAVYTAAEYLQNYAIAYSQYPGPEVASALDPQSYATPVAY--LNGQIPLWFPDSDLQLPDDLESDDGREKRIALGSLLRRHSVMHVLLHDLQGGILSERECLENLQVMLQSILALIAQARLEVPETEHDRQKRLQAKKARSQLWLREMRRLVASVAKTPRLVFADDVAVEDRELPVIHCATGWASLRHGQSVQLETDLDGIYRQFFEKGRSIVLAFPDNNEKAVSGAHQKLCPTCLKL--QGISILGSRAASLSAVMIHQLYG------SQFNEHKKLIVQDAAHRASFFTARTWPLMIRGQIASVLSEK----ETLPLDAFAARVCQQTRERSPDDAHFAANVIAPNMQWLNDYQTLKNEGKLAENSDLPELVSLRLDWEVYSEFTLRARIGRTLEAT......................................................................................................................................................................... 760
31 -11.200[A] KOG0345 ATP-dependent RNA helicase  ali follow..  13  38........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FCTPVQAATIPLLCSYKDVAVDAATGSGKTLAFVVPLVEIKPHQV--MGVIISPRELSTQIYNVAQPFVSTLANVNSV---VGGREVKADMKIIEEEGCNVLIGTPG-----------------------------------------------------RLSDIMERMEILDFRNLEILILDEADRLLEMGFQRQVNYI--------------------ISRLPKQRRTGLFSAT-QTEGVEEL-----------------------AKAGLRNPVRVEVRAKSKSESSQQLTNSKTPSGLHLEY----------------------------MECEADKKSSQLVDLLIKN-------------SDKKLIVFFMTCASVDY---------------------------------------------------------------------WGLVLSKIPALKSIS---LIPIHGDMKQNARDKALASFTKASSGALL-CTDVAARGLDIPG-IDYVVQYDPPQDPNMFNHRAGRTARLGRQGRAIVF---------------LLPKEEAYVEFMRIRRVPLEERK-CSEDASDVIPIIRSAAMKDRAVMEKGL.................................................................................................................................................................................................................... 431
32 -11.000[A] KOG0336 ATP-dependent RNA helicase  ali follow..  12  244........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KPTPIQSQAWPIILQGIDLIVVAQTGTGKTLSYLM-------------PGFI---HLDSQPISREQRNGPGMLVLTPT---------RELALHVEA---ECSKYSYKGLKSICI--------RNGQIEDISKGVDIIIATPGRLNDLQMNNSVNLRS-------------------ITYLVIDEADKMLDMEFEPQIRKI--------------------LLDVRPDRQTVMTSAT-----------------PDTVRQLA----------------------------------------------------------------------------------LSYLK---------------------DPMIVYVGNLNLVAVNTVKQNIIVTTEKEKRALTQEFVENMSPNDK-------------------IMFVSQKHIA----------DDLSSDFNIQGISAESL---HGNSEQSDQERAVEDFKSGNIKILI-TTDIVSRGLDLND-VTHVYNYDFPRNIDVYVHRVGYIGRTGKTGTSVTLIT--RDSKMAGELIKILDRANQSVPE............................................................................................................................................................................................................................................................ 595
33 -10.900[L] COG0514 Superfamily II DNA helicase  ali follow..  14  37........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QFRVGQQEVIEAALAGRDSLVIMPTGGGKSLCYQIPALVLEGVTLVISPLI----SLMKDQVDQLKANGVAAECV---NSTLAREELIAIYNRMHAGQLKLLYVS--------------ERVLTAEFIER-----------------------------------------LSHLPLAMIAVDEAH---------------------SQWGHDFYASLGQLKQRFPNVPVMALTATADDA-----------TRHDIMQRLQLNEPHQYLGSFDR--------PNIRYMLVEKHKPVSQVIRYLETQRGQCGI-------------------------------------------------------------IYCGSRKKV------------------------------------------------------------------------EMLTEKLCGNHI---RAASYHAGMDADERAWVQEAFQRDDLQIVV-ATVAFGMGIN-KPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMMLYDPA-----DMNWLRRMLDEKPDGAQKQVESHKLTAMGAFAEAQ.......................................................................................................................................................................................................................................... 390
34 -10.800[A] KOG0342 ATP-dependent RNA helicase pitchoune  ali follow..  14  38............................................................................................................................................................................................................................................................................................................................................................................................................................QDEDDYEQEEENEDADQNTSVESESEELDNENEDERVQKSVNLNASSTSDIEKFSDLQLSENIQKAIKEMGFE---TMTEIQKRSIPPLLAGRDVLGAAKTGSGKTLAFLIPTIEMLYALKFKPVIIISPRELALQIFGVAKELLKYHHQTF------------------------GIVIGGANRRA--------------------------------EADKLVKGVNLLVATPGRLLDHLQNTKGFVFRNLRSLVIDEADRILEIGFEDEMRQI-----------------MKILPSENRQTLLFSATQTTKVEDLARISL-----------------------------------------------------------------------------------------------------------------------KPGPLYVNVDSGKPTSTVEGLEQGYVVVDSDKRFLLLFSFLKRNLKKK--------------------IVFMSS-----------ASVKYMAELLNYIDLP---VLDLHGKQKQQRRTNTFFEFCNAEKGILL-CTNVAARGLDIPA-VDWIVQYDPPDDPRDYIHRVGRTARGTKGTGKSLMF--------------LAPSELGFLRYLKTAKVSLNEFEFPANKVANVQSQLEKLVSKNYYLQQSAK.................................................................................................................................................................................................................... 491
35 -10.800[LKJ] COG0513 Superfamily II DNA and RNA helicases  ali follow..  17  24........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................APTPIQAGAIPPALERKDVLGIAQTGTGKTASFVLPMLTLLEKGRARRTLILEPRELAAQVEENFVKYGINHRLNV------------------------ALLIGGVSFE--------------EQERKLERGADVLIATPGRMLDHFERGKLLLTG-------------------VEILVIDEADRMLDMGFIPDIERI--------------------CKLIPFTRQTLFFSAT-MPPEITKL------------------------------------------------EQFLHSPVRIEVAKASSTAKTVTQRLVKSGK---------------------------------------------------KDWDKRAVLRDLIQSEGDSLKNA------------------------------------IIFCNRKKDV----------SELFRSLTRHEFDAGAL---HGDMDQRARMAMLSSFKDGKLRLLV-ASDVAARGLDIPD-VSHVFNFDVPIHAEDYVHRIGRTGRAGRSGKAFTIV..................................................................................................................................................................................................................................................................................... 351
36 -10.700[J] KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins  ali follow..  11  159..........................................................................................................................................................................................................................................................................................................................................................................................................................................................QYDVTITPEVSSKSVNRAIIAELVRLYKESDLGRRLPAYDGRKSLYTAGPFTWKEFSVKIVDEDDGIINGPKRERSYKVAVARANMHHLGEFLAGKRADCPQEAVQILDIVLRELSVKRFCPVGRSFFSPDIKTPFYQSIRPTQMGLSLMASAAF--------IEPLPVIEFVAQLLGKDVLSKPLSDSDRVKIKKGLRGVKVRVAGLTTQPTRELMFDENCTMKSVIE--YFQEMYGFTIQHTHLPCLQVGNQKKASYLPMEAKRLNEKQITALLKVTCQRPRDRDILRTVQHNAYDQDPYAKEFGMNISEKLASVEARILPAPWLKYHENGKEKD-FSRSVQENVARGFCNELGQMCEVSGMEFNPEPVKTKGKELELLLAHVFKISKQYLANVSLKINKMGGRNTVLVDAISCRIPLVSDIPTIIFGADVTHPENGEESSPSIAAVVASQ--------DWPEVTKYAGLVCAQAHRQELIQDLYKTWQDPVRGTVSGGMIRDLLIATGQKPLRIIFYRDGVSEGQ----FYQVLLYELDAIRKACASLEPNYQPPVTFIVVHHT--ANNHRDKNSTD----RSGNILPGTVVDTKICHPTFDFYL-QGTSRPAHYHVLWDENNFTADGIQSLTNNLCYTYARCTRSVS.............................................................................................................................................................................................................................. 926
37 -10.600[V] COG3587 Restriction endonuclease  ali follow..  10  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................MSGFNYE----KNQPHQMRAVSAVLGVFDGATPKYRTAD------ENPELLFAAKQYANNILKVQSQNGIISMETGTGKTYTYTQTMFELHRWLGVFKFIVVV----------------PTLSIKAGTQQFLQSKALAEHFEQDFGGDYEGVRLKTYVVESAKKNKGKKSNAPITIEQFVKAENKKEIHVLLINAGMVNSSSMNDTGDKALKDLFDNPVDALAAV--PFMIVDEPHKFPTRDSAKTWGNIKRLKPQYILR----------------------YGATFNDEYYNLLYRLVDAFNDGLVKGVRVFQEEM-KLVSSDGKEAKFELNEKDKKQTFKLAKGEDLAQIHPAISDLKIDKMNKTVVVLSNGLELKTGAVINPYSYSQTVQDAMMQRAVAEHFKLERALLAERAPQPKIKPLT-------ID-DIAGYRSGNELSGSLKDKFESWIRAEAARRLKTESDPFYRDYLQKTLDDVSACHGGYFSKDNTDSDDRIEQEINEIL------------------HDKEKLLS---DNPRRFIF-SKWTLREGWDNPN-VFQICKLRSSGSTTSKLQEVGRGLR-ARVRDVPYKLNYFVDSSEKDFVKQLVGNDNSFQEEISKKFTEELKQKILQKYPDIKPLVLVNQLFLDGIIDDNENFAEDGYDKLKAAYPEAFPKGLDKGKVSNAKDEGKDTIIMREGKYEELKALWELIHHKAVLQYK---IKDEAEFADLFTAYLHE................................................................................................................................. 701
38 -10.500[A] KOG0340 ATP-dependent RNA helicase  ali follow..  16  80........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KPTPVQTHCVPKILAGRDVLGLAQTGSGKTAAFALPILHLAEDPYGVFALVVTPRELAFQLAEQFKALGSCLNLRC------------------------SVIVGGMD--------------MLTQTMSLVSRPHIVITTPGRI--------------KVLLENNPDVPPVFSR--TKFLVLDEADRVLDVGFQDELRTI--------------------FQCLPKSRQTLLFSAT-MTSNLQAL------------------------------------------------EHSSNKAYFYEAYEGLKTVDTLTQ----------------------------------------------------QFIFEDKDAKELYL-VHILSQMEDKGIRSAM-----------------------------------IFVSTCRTC----------QRLSLMLDELEVENIAM---HSLNSQSMRLSALSKFKSGKVPILL-ATDVASRGLDIPT-VDLVINYDIPRDPRDYVHRVGRTARAGRGGLAVSII-----TETDVKLIHKIEE................................................................................................................................................................................................................................................................... 419
39 -10.300[A] KOG0332 ATP-dependent RNA helicase  ali follow..  163...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EEAHEQVPVPADIALLNKFIQKEVKMMKDVVVDVQRQDPKSPLYSISSFRELRLKPEVLKALDTM-NFQFPTRIQE-TALPLLLMEPPSNL------IAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLAPTLELAKQIGEV-VEKMGKFIDNLKIHYAIKGGNMAAMRGRKLTEQIV---GITRDYLQKYKC--------IDPSKIRCLVLDEADVMIY-HQGFTDISTTIYNMVEDASDSVQSMLPVINFATKIIKNAIVVMLKREEQALPNIKQFYVQC-----ACRDSKYAAIVNLYSGLAVASSVIFCHTKASV----------MWLYENMRARGH---QVDVLHGDMTVVERADTIIHFKRGDFKVLI-TTNVFARGIDVAQ-VSVVINYDLPIKCETYLHRIGRTGRFGKTGIAINLID------------EDSMNMINVLENHFQMKIARMDPSNLVELEAIEMA..................................................................................................................................................................................................................................... 613
40 -10.300[A] KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1)  ali follow..  16  408........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QLNSSQSNAVSHVLQRPLSLIQGPPGTGKTVTSATIVYHLSKI--------------------------HKDRILVCAPSNVAVDH---LAAKLRDLGLKVVRLTAKSREDVSVSNLALHNLVGRGAKGELKNLLKLKDEVGELSASDTKRFVKLVRKTEAEILNKADVVCCTCVGFRTVLIDES-----------------------TQASEPECLI------------------PIVKGAKQVILVHQQLGPVILERK--------AADAGLKQSLFE-----------RLISLGHVPIRLEVYRMNPYLSE--------------------------PSNMFYEGSLQNGVTIEQRTVPNSKFPWPIR------------------------------------------------------------GIPMMFWANYGREEISANGTSFLNRIITKLFRDGVKPEQIGVITPYE--------------GQRAYILQYMQMNGSLDKDLYIKVEVASVD-----------------QGREKDYI-ILSCVRANE---------QQAIGFLRDPRR-------------NVGLTRAKYGLVILGNPRSLARNTLWNHL............................................................................................................................................................................................................... 824
41 -10.300[A] KOG0335 ATP-dependent RNA helicase  ali follow..  16  254...................................................................................................................................................................................................................................................................................................................................................................................................................................DEDSIFAHYQTGINFDKYDTILVEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYT-------------KLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLL-------------PIL---AHMMHD-SRFKELQEPECIIVAPTRE-------NQIYLEARKFSFGTCVRAVVIYGGTQLG---------HSIRQIVQGCNILCATPGRLMDIIGKEKIGLKQ-------------------IKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLM---------------------------------------------------FSATFPEEIQRL-----------------------------AAEFLKSNYLFVAV-------------------------------------------------------GQVGGACRDVQQTVLQVGQFSKREKLVEILRNI-------------------GDERTMVFVETKKKA----------DFIATFLCQEKISTTSI---HGDREQREREQALGDFRFGKCPVLV-ATSVAARGLDIEN-VQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDLESDNHLAQPLVKVLTDAQQDVPAWLEE........................................................................................................................................................................................................................................................ 673
42 -10.200[V] COG1002 Type II restriction enzyme, methylase subunits  ali follow..  29...................................................................................................GIFPKEIHSVEEHPDSVVINGSVFNSKIKNQRSQLVKQIKEKGYEQVMEEVTYTWRLVALKFMEMNGCLQD-QIKVFTSTDPNKPEPDLLTNALKLDFLNLNRDLVLDLKAENKDEELYKYPFLFEKELLFPDKLLHTGSVLHDLNSIIPDEDWQEVEIIGWIYQDYIAPKKDKVVTQLF----TPHWIV--RYLVENSLGRL-VKPEQQETDFLKINSPEELKICDPA----------CGS---------HMLVYAFDLLYAIYEEEGYTPSEIP-----EIILTHNLFGIEDKRAGELAGFALTMKARGKDRHFFKKQVQPNICMLENITFEQSELDAYIDAVGS---------ELFTNAHRATLLQFAEADNFGSLIRPAAMEVS-GLLSLLESKNLSGNLSHLSTHQKVLQALKQADYLSPKYHV----VIANPPYMGNKGMNNRLKTFLQNNYADVKFSAFIVRNTELAFPKGQLGFMSPFVWSLIQLEYSGFDGATVPICTFTSENAYHPEFKGGYVRLSDFRGAENQSPKTLEAIKNPKCGWFYRASATDFKKIPGNPIAYWVSNKVRDFGNITLGDFFDTEGQNKTTDNDKYLKYHWELREKTIGVDKKWVLCAKGGSFRKWQGNIEYVIDW-KDHSARIVEEEFWYREGITWTGITSSFRYLEYGCTYETAGPTIFVKNANKYVILGYLNTPIVAKFINIMNPTLNTKIKDVQALPIIQSILFDNQVESVSLRLVNLSKSDWDSYETSTTLPFLQSEFRQPTLSETYTKLRTHWKEMTLEMQRLEEFIEAYGLQDEITPEVPLSEITLTCNPYYRYGNNKTEEELETLLMTDTVKELVSYAVKEGLILANQGEKLGDFKEKVPRATFLPDEDN----IIPILDDEYYTDDIVGRFKEF--LKHTFGAETLSENLNFIISKKNESPGKVIRDYFLKDFYKDHV--KMYKKRPIYWLFTSSEKG-------------AFNALVYMHRYDKTTLAKMRLLDFESKLDAQRSLLKKEITENSKNSGKAESELAKLNKKINELVKYDELLKNKADQMIEIDLDDGVKVNYEKFKGLVGKI.................................................................................................................................... 1161
43 -10.200[E] COG2902 NAD-specific glutamate dehydrogenase  ali follow..  560..................................................................................................................................................................................................................................................................LSRRVPLLENLGFNVISERTFDIGVVSEGEKRDIVLH-ELSVAAGTTLDLPHYGPKLEEAFLAAFSGKVDNDNFNRLILACGLNVREVSVLRAYARYLRQTGIVYSQEHISETFKAGFDPSIEEKKRVKKLAEIHKAIEAALSGVPNLDEDRTLRRYVNAIDATLRTNYFQKNADGTPRDLLAFKFDPKHLDGLPDPRPFREIF------VYGTEVEGVHLRFGKVA---------RGGL-RWSDRGQDYRTEVLGLVKAQQV--------------KNAVIVPV---------------GAKGGFFPKNLPAGGSRDEVFNAGRE--YKTYI---RTLLSITDNIVDDAIVPPADTLRLDPYFVVAADKGTATFSDTANGLAHEAG--DAFASGGSAGYDHKKMGITARGAWETRHFREMDTDIQTTPFTVADMSGDVFGNGMLLSEKILIAAFDHRDIFI---DPDPDTDKSFAERKRLFE---LPRSSWQDYDR-AMIISRSEKSVTLTPEAVAAIGLDKSVATPFEIMTAILKAPTDLLWFGGIGTYIKNAEVGDRANDPIRVNATELRAKVIGE-KGRIAYALAGGRCNSDAIDNSAGVNSSDVEVNIKIALASAVNSPKRNQLLASMTPDVAQLVLRNNYQQSL-------------------ISLTERLGLANREELGRLMGALEATGQLNRKVETLPNNAEFSERYASGKPLTRPEIGVLLSYAK-----LTLFDALVASPLPDEPY-PAKMQKNYANDIKAHRLHREI-VATALANAVVNGFVQKLADASGLLAADVVKAAVIVEDGFGLKR---TEVDALDGKVGGQVQNGLYATITRIFSDASRLYLQTGSAGAAAGDMATEIERLKTAIKTLSPAATKYRRELGVTEISGLLEELDTLSLLVYVPEIMRIAESAGTTLARAAESYATVSSTFRVA-RLLDASQRITPADHYESLALLRSQDQISSSRRRIVISALTEYAKEKDPVQAWYAADRVRVNRIVSELGALSES-------GDTNLARLTVAAGLLGDIVQAR....... 1585
44 -9.930[A] KOG0326 ATP-dependent RNA helicase  ali follow..  16  48..........................................................................................................................................................................................................................................................................................................................................................................................................................................AQSMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWE---KPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNQAMVIVPRELALQVSQICIQV--------------------------------------KHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDH-------------------VQMIVLDEADKLLSQDFVQIMEDI--------------------ILTLPKNRQILLYSAT-FPLSVQKF------------------------------------------------NSHLQKPYEINLMEELT-------------------------------------------------------KGVTQYYAYVTERQKVHCLNTLFSRLQINQS--------------------------------------IIFCNSSQRV----------ELLAKKISQLGYSCFYI---HAKMRQEHRNRVFHDFRNGLCRNLV-CTDLFTRGIDIQA-VNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLI..................................................................................................................................................................................................................................................................................... 427
45 -9.890[A] KOG0330 ATP-dependent RNA helicase  ali follow..  13  11..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DKKNSSLNKKIETSNSSSEKSSENNNGDSQNNEAPKTFKELGVIDELCEACEKLEAIPVVLNKRDVIGLAQTGSGKAFALPVIQELWNNPSPFFAVVLAPTRELAYQISEQF-----------------------EAIGGSIGVRSVVIVGGMDMVTQAVALSKKPHVL---GRLMDLENTKGFSLKNLKYLIMDEADRLLDMDFGPIIDKILKIIPHERRTL-------------LFSATMTSKVEKLQRASLHQPVRVAVSSKFSTVDTLIQRYLFFPFKHKDTYLVYLVNELAGNSIIIFARTVNDT----------QRLAILLRTLGFSAIPL---HGQLSQSNRLGALNKFKSGARSTLV-ATDVAARGLDIPL-VDVVINYDIPTDSKAYIHRVGRTARAGRAGKSIALV-----TQYDLEPFLRIEA................................................................................................................................................................................................................................................................... 402
46 -9.850[O] KOG0743 AAA+-type ATPase  ali follow..  213.......................................................................................................................................................................................................................................................................................................................................................................................................................................................MDPNAKKKIIDDLERFLKRKEFYKRV-----------------GK-------AWKR----------GYLLYGPPGTGKSSLIAAMANYLK--------DLELSSIYDNGELKRVLLSTTNRSILVIEDIDCNAEVRDRILNFISFGDERIIVFTTNHKERLPLCEEIEALVDSTEVTELAEEL--QDDDTDVVLRGVISFVEKRKVERSKTKKEVSICKATDDDEKQNGSLGCVKKKKKGGKQKGKGKARSKEIPQDNCGFRLTEMFPSISNISLSPSSLFTAYASLTGFLMLFRSLFNDEVPERLRSYITDLLNRFFTPKSKNLTRNKIGPETARLRVGKLPKQKHFTIYIEKGEEILDTFENSELRWTYVESENEASQKEKRYYELTFEKKSYLSHVVAESEETKRDLRAVKGMAGAGWGCINLEHPSTFETLAMDPGAKKKIIDDMERFLKR--EFYKRVGKAWKRGYLLYGPPGTGKSSLIAAMAN--------KFDVFDQLKSILLS--TTNRSILVIEDIDQEYEEGYYGRVTLSGLLNFVDGLWSSFG-----DERIIVF-------TTNHKERLDPALLRPGRMDMHINM-SYCTGLGFRTLV-------SNYLGLGGLNHPLCEEIEALIDSTEVTPAELAE------ELMQEDDTDVVLRGVVSFVENRKVEISKTKELEGSTCRKLDGDDKHNVSSTNDLKKTKKKKKGG........................................................................................................................................................... 989
47 -9.850[A] KOG0344 ATP-dependent RNA helicase  ali follow..  14  14..................................................................................................................................................................................................................................................................................................................................................................................................................................QRESKLTSGKLENLRKEKINFLRNKHK--IHVQGTDLPDPIATFQQLDQEYKINSRLLQNILDAGFQ---MPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMKQPANKGFRALIISPRELASQIHRELIKISEGTGFRIH----HKAAVAAKKFGPKSSKKFDILVTTPN--------------------------------------------------RLIYLLKQDPPGIDLAS--VEWLVVDESDKL----------------------------------------------------------------------------FEDGKTGFRDQLASIFLACTSHKVRRAMFSA-----TFAYDVEQWCKLNLDNVISV-----------------------------------SIGARNSAVETVEQELLFVGSETGKLLAMRELVKKGFNPP---------------------------------------LVFVQSIERA----------KELFHELIYEGIN---VDVIHAERTQQQRDNTVHSFRAGKIWVLI-CTALLARGIDFKG-VNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFT--DDKPLLRSVANVIQQAGCPVPEYIKG........................................................................................................................................................................................................................................................ 436
48 -9.830[TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family  ali follow..  893....................................................................................................................KIKTIVGIEKMLSVKLGLPQILSNLQSAFQNEHLRFYAIKAWFSLILA---TKEPEYSSIAGEPQEAELVIQIFDFISSDTHKCLQGLKWAIPTSLDSACFSLKAKEIFCSLQNEDFYSELQSIIKCLTNENEPVCYLGLQKLELFFQAKVDELHDTLNL-----------DISNEVLDQLLRCLLDCCVKYASTNMQISY-LGELGAIDPSRAKAQHIIKET-DNFENGEESLKFILDFMQSQLIPAFLVTTDT-------------------KAQGFLAYALQEFLK----------------------GFKSAVINKKKGLTVVTEHWMSLPDLSKRVLIPFLTSKY---HLTPIPKIDIRYPIYKENVTIHTWMQLFSLKLMEYAHSQNAEKI-----FGICSKVVKDQEVNIPC---FLLP--------------FLVLNVILTESELEVNKVIEEFQL----------VINQPGPDGLNSVGQQRYTSFVDVFFKIVDYLNKWLRMRKKRNWDRRSAIARKENRYMSVEDATSRESSISKVRFPSKTLGIV----------------------SLNCGFHARALFYWEQHIRNATAPYAALESDYRVLQEIYAGID--DPDEIE--AVENSGTWDSALSCYEIIIQKDPENKKAKIGLLNSMLQSGHYESLVLSLDSFIIND-----------------------NHEYSKMLNLGIEASWRSLS---------DSLKKCLSKSNLESFEAKLGSIFYQYLRKDSFAELTERLQPLYVDAATA-----------------------------ANTGAHSAYDCYDILS-------KLHAINDFSRGIVSDNLDIVLRR--------RLSQVAPYGKFKHQILSTHLYEKFENTKKTAEEIARISRKGQFQRAFNAILKAMDLDKPLATIE----HAQWWWHQGQHRKAISELNFSLNNNMFDLVDEHEERPKNRKETLGNPLKGKVFLKKWLGKAGQLGLKDLETYYHKAVEIYSECENTHYYLGHHRVLMYEEEQKLPVNE-QSERFLSGELVTRIINEFGRSLYYGTNHIYESMPKL--LTLWLDFGAEELRLSKDDGEKYFREHIISSRKKSLELMNSNVCRLSMKIPQLSQMISRVCHPNNKVYKILEHIIANVV-ASYPGESTSQKRSLRGKSILNVLHSRKLSMSSK 1969
49 -9.670[A] KOG0333 U5 snRNP-like RNA helicase subunit  ali follow..  12  323........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EPTPIQRQAIPIGLQNRDVIGVAETGSGKTAAFLL-------------PLLVWITSLPKMERQEHRDLGPYAIIMAPTR-ELAQQIEEETNKFGKLLGIKTVSVIGGA--------------REDQGMKLRMGVEVVIATPGRLLDVLENRYLLLNQ-------------------CTYVILDEADRMLDMGFEPDVQKVLEYMPDTNMK--------------------------KDTDEFDNEEALMKGFSTREKYRQTV-----FTATMSSAIERLA-------------RQYLRRPAVVHI-----------------------------------------------------GSAGKPTERVEQVVYMVPEDRKRKKLVEVLESQFQPP---------------------------------------IIFVNQKKGA----------DMLSKGLTKLGFKPTVL---HGGKGQDQREYALQALKEGTSDILV-ATDVAGRGIDVKD-VSLVLNYDMAKSIEDYTHRIGRTGRAGKHGKAITFLTPDDTAVYFDLKQVLVESPVSSCPP............................................................................................................................................................................................................................................................ 702
50 -9.650[L] KOG2108 3`-5` DNA helicase  ali follow..  246........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SLNDRQRDAACSNISTPLMVIA--PGSGKGLLILAMTFTKAATSEMRERISAGKKAAKDITISTFHSF---LQLC---RMHADKLQRTSEFSVYGHGQQRRAIVRLYEEEKKNGSKTSVPCESGEGLNGAGAGAGKASGKSPEQCRKMGNEIGAKILGNYNDILKACDALDYHDL-WKAIIVDEFQQYKLLRMLGSHNHITIVGDDDQAQCAYVIDKIIEITNDGSTPCCSHGDIAILYRRQVSGKVFQNAFRQRKINVHGVAFYRK-QVILAMLKTTFSECDDASYRRVFKALLPFEKEEKKRIIEHIEKISTSRKCSFISAASDIFNAKISGTFKRSQLTQGRKVLQTLDMVAKLVDREQSLSAVVTCVANMIPQKYLLEQRAVVDNDGEDNDLRSVLQYLMDDVAEFISTHCTT------------------------TEEEDAIKEKKGCNQLHSFI-------NYISERETENFRSRRRD-----NENSVTLT---TIHQANENEIP--LLHESNGNASESGTSLEE-ERRLLYVAMTRARKKLFFLYVTVDSNWQGDMSVNDCRKVHENL........................................................................................................................................................................................................................................................... 825
51 -9.540[L] COG4098 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein)  ali follow..  14  92......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RGQLTPFQEKVSEGLLKQKPTLVHAVTGAGKTEMIYQVVAKVINAG--GAVCLASPRDVCLELYKRLQQDFSCGIALLHGESEPYFRTP-------------VVATTHQLLKFYQ--------------------------------------------------------------AFDLLIVDEVDAFP---------------------VDNPMLYHAVKNSVKENGLRIFLTATSTNELDKKV--------------------------------------LGELKRLNLPRRFHGNP---------------------LIIPKPIWLSDFNRYLDKNRLSPKLKSYIEKQRKT----------------------------------------AYPLLIFASEIKKG---------------------------------------------EQLAEILQEQFPNEKIGFVS--SVTEDRLEQVQAFRDGELTILI-STTILERGVTFPCDVFVVEANHRLFTKSSLIQIGGRVGR-SMDRPTGDLLFFHDGLN------ASIKKAIKEIQMMNK......................................................................................................................................................................................................................................................... 428
52 -9.390[L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits  ali follow..  10  367....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PGEYILDSSQLKAYQSMLTKRLSIIQGPPGTGKSFVTLKAIETLENTHSHVLPILVATNHAVDQILIRLLHQ--GASVMRLGSRTKDPEIAAVTIFQKA--------------KHTKHSFKAAYNEIRHKKQRLIKQITNIMHNFNLEFVTLSYLHSKGIITTSQLESLRNNSIWLGDAKVELITPSEITDGFEEELQIDPEKLEEIQKEAEDSGALMEEELRGKFINLRCKYLFSKLTTLHEKEIDTLLTIPNIWDIPEYSRGII--YCRWLESAYAAAEKELNRLYRFYLKVDRERIGFSNKRAAILLRG-ANVIGMTTTGLNKYRDILERINPKICFIEEAADVLEIIPAVFPSLEQL-GDHKQLRPGCSTYLRQDPFNLSISMFERLVENDME-TMQRRMHPQIRRLVSVYEDLSDYEIT-KYWPSIPGMGEIRRFFLTHSRIEDNDGSKINLFEQFAVYLINNGVEPQKITCLTFY--------------AAQKDLI---ERLLSESLNREKHFIKVATVD-----------------QGEEN-DVVLLSLVRNND---------RTEVGFLSSPHR-------------CVSLSRARRGLFIFGNAQLVAESN.................................................................................................................................................................................................................... 949
53 -9.260[A] KOG1804 RNA helicase  ali follow..  13  309........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VLNENQKLAVKRILSGDCYILFGPPGTGKTVTIIEAVLQV-------------------------HFALPDSRILVCAPSNSAA---------------DLVCLRLHESKVLQPATMVRVNATCRFEEIVIDAVKPY---------------CRDGEDIWKASRFRIIITTCSSSGFTHVFVDEA---------------------GQASEPECLIPLGLMSDISGQ---IVLAGDPIKSRLAMAYGLNVSFLERLMSRPAYQRDENAFGACGAHNPLLVTKLVKNYRSHEALLMLPS-----RLF---------------------------------------YHRELEVCADPTVVTSLLGWEKLPKFHGVRGSEAREGKSPSWFNP-------AEAVQVLRYCCLLAHSISSQ--------------------------SASDIGVITPYRKIRILLRNVDLMDIKVGSVEEFQGQEYLVIIISTVRSNEDRFFLSNSKRFNVATRPKALLIVLGNRDPCFG............................................................................................................................................................................................................................................................................................................. 724
54 -9.230[A] KOG0338 ATP-dependent RNA helicase  ali follow..  14  185.........................................................................................................................................................................................................................................................................................................................................................................................................................................KADTLKVKDRKKKKKKGQEAGGFFEDASQYDENLSFQDMNLSRPLLKAITAMGFKQP---------PIQKACIPVGLLGKDICACAATGTGKTAAFALPVLERPRQAPVTRVLVLVPRELGIQVHSVTRQLAQFCNITT------------------------CLAVGGLD--------------VKSQEAALRAAPDILIATPGRLIDHLHNCP------------------SFHLSSIEVLILDEADRMLDEYFEEQMKEI--------------------IRMCSHHRQTMLFSAT-MTDEVKDL--ASVSLK-----------------------------------------------------------------------------NPVRIFVNSNTDVAPFLRQEFIRIRPNR------------------EGDREAIVAALLTRTFTDHV--------------------------------------MLFTQTKKQA----------HRMHILLGLMGLQVGEL---HGNLSQTQRLEALRRFKDEQIDILV-ATDVAARGLDIEG-VKTVINFTMPNTIKHYVHRVGRTARAGRAGRSVSLV-----GEDERKMLKEIVKAAK--APVKARILPQDVILKFRDKIEKMEKDVYAVLQLEAEEKEMQQSEAQINT............................................................................................................................................................................................................. 632
55 -9.200[L] KOG1132 Helicase of the DEAD superfamily  ali follow..  11  28........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QIGGLQVEFP-----YQPYGTQLAFMSRVISHCHALLESPTGTGKSLSLLCSVLAWQQ---ETQPSDTPASTNVEKAETATKKRTKIPTIYYASRTH---SQITQVIREYRKTGYRVPMAVLASRKHYCTNRHVLGKRGHNEVHDIEDLVKVGKNVR--ASWSMAENAQLVFCPYSYIVNPV------AGVEVDLIIFDEAHFFSMLLMLMIRPSTKSFTVHSNMEDIAREAELQNELEQDISLSVILTSGTPMNSFSSELGMQFGT----SLEAPHV---QVWAGAISNGPSNYPLNASYKTADAYSF-----QDALGKSLEEICTI---------VPG---------SLVFFPS----KLMEKLCMR-------------RETEQWSRLCLKKDLFVEPR-------GGAQDEFDSVLKGYYDSIRGKNKAGPIKTETQDDSKKGAAFLAVC-----RGKVSEGIDFADDNARAVVEDYTNSNPKY--------ESKAFGYHRDVKPKIAEDLRSM-----------SAQTFVQVK----------EEAECCREVIDLECG........................................................................................................................................................................................................................................................................................ 704
56 -9.010[A] KOG0343 RNA Helicase  ali follow..  12  63........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KLTEIQADSIPVSLQGHDVLAAAKTGSGKTLAFLVPVIEKLYREKWTEALIISPRELAMQIYEVLTKIGSHTSFLVIGGKDVKFELER-------ISRINILIGTPG-----------------------------------------------------RILQHLDQAVGLNTSNLQMLVLDEADRCLDMGFKKTLDAI--------------------VSTLSPSRQTLLFSAT-QSQSVAD------------LARLSLTD-----------------------------------YKTVG---------------------------------------------THDVMDGSVNKEASTPETLQQFYIEVPLADKLDILFSFIK----SHLKCKM----------------------------------IVFL-------SSSKQVHFVYETFRKM-QPGIS---LMHLHGRQKQRARTETLDKFNRAQQVCLF-ATDVVARGIDFPA-VDWVVQVDCPEDVDTYIHRVGRCARYGKKGKSLIMLT---------------QEQEAFLKRLNARKIEPGKLNIKQSKKKSIKPQLQSLLFKDPELKYLGQ-KAFISYVRSIYVQKDKQVFKFDE............................................................................................................................................................................................ 471

FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 6 1 8   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster

Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24