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Query: [C] COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MFKLFTARQHDKIWDFDGGIHPPEMKLQSSTVPMRIAPLPDQLIIPLQQHLGPEGELRVRAGEQVLKGQPLTVGRGRTVPVHAPTSGMITAIAPHTTAHPSGLAELCVHITPDGEDRWREQQPWADYRQRDKMALLDRIHQAGIAGLGGAGFPTASKLQGGLNGIITLIINAAECEPYITADDRLMQEHADEVITGIHILRHLLQPQQVLIGIEDNKPEAIAALQRALRGQDDIHLRVVPTKYPSGGAKQLTKILTGKEVPFGKHSSSIGVLMQNVGTVVAIKRAVIDDEPLIERVVTLTGDALSSPGNFWARIGTPVLYLLKLAGFKPQNPPMVIMGGPLMGFTLPSLDVPIVKISNCILAPAETEMGLSEPEQSCIRCGLCVDACPAGLLPQQLYWFSRGEEHEKARNHNLFDCIECGACAYVCPSNIPLVQYYRQEKAEIRALDQESARAAEAKARFEAKQARLAREKLARELRHKQAAVKLTDADQQTVDAAVSRLTRQSDGSESVINIPAGQMPDNSAVIAAREARKAQARARQAEKQQARSTEETTDVVDPRQAAVAAAIARVKAKKAVQAQHVTTDVAEAGSEAMAEDPRKAAVAAAIARVKAKKAAQAINPDLast
1 -145.000[C] COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC  ali  100  1MFKLFTARQHDKIWDFDGGIHPPEMKLQSSTVPMRIAPLPDQLIIPLQQHLGPEGELRVRAGEQVLKGQPLTVGRGRTVPVHAPTSGMITAIAPHTTAHPSGLAELCVHITPDGEDRWREQQPWADYRQRDKMALLDRIHQAGIAGLGGAGFPTASKLQGGLNGIITLIINAAECEPYITADDRLMQEHADEVITGIHILRHLLQPQQVLIGIEDNKPEAIAALQRALRGQDDIHLRVVPTKYPSGGAKQLTKILTGKEVPFGKHSSSIGVLMQNVGTVVAIKRAVIDDEPLIERVVTLTGDALSSPGNFWARIGTPVLYLLKLAGFKPQNPPMVIMGGPLMGFTLPSLDVPIVKISNCILAPAETEMGLSEPEQSCIRCGLCVDACPAGLLPQQLYWFSRGEEHEKARNHNLFDCIECGACAYVCPSNIPLVQYYRQEKAEIRALDQESARAAEAKARFEAKQARLAREKLARELRHKQAAVKLTDADQQTVDAAVSRLTRQSDGSESVINIPAGQMPDNSAVIAAREARKAQARARQAEKQQARSTEETTDVVDPRQAAVAAAIARVKAKKAVQAQHVTTDVAEAGSEAMAEDPRKAAVAAAIARVKAKKAAQAINPD 620
2 -63.300[C] COG1726 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA  ali follow..  16  1............MITIKKGLNLPISGSPEQ--VIRDGNAITEVALLGEEYVGMRPSMKVREGDVVKKGQVLFEDKKNGVVFTAPASGTVTAIH-----RGAKRVLQSVVIKIEGNEQITFEKTTEQLNQLTSEQVRQNLQASGLWTALRTRPFSKVP--AVDATPVSIFVNAMDTNPLCADPQVIVQQSAQAFEAGLTVLSRLHEGKVYLCKAANASIPSPSI--------ANLDVKEFAGPHPAGLSGTHIHFIDPVSATK-------FVWYINYQDVIAVGKLFTTGELDVSRVVSLAGPQVKNPRLVRTVLGANLSQLTA--NEVKDGENRVISGSVLSGAKAAGPVDYLGRYALQVSVLEEGTTALNGGERAMVPIGAYERVMPLDIIPTLLLRDLAAGDTDSAQALGCLELDELALCTFVCPGKNEYGPLLRQALDKIEKE.............................................................................................................................................................................. 445
3 -51.900[C] COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit  ali follow..  18  34...............................................................................................................DEYRSKNGYAGAEKALKGMAPTDVVNVVKDAGLKGRGGAGFSTGLKWSDDSMNIRYLLCNADEMEPGTYKDRLLMEQLPHLLVEGMLISAFALKAYRGYIFLRGEYIEAAVHLRRAIAEATELIVHTGAGRYICGEETALINSLEGRRANPRSKPPGKPTCVNNVETLCNVPAIIEHGVEWYTKLMGFSGR-VKNPGLWELPFGITAREILEDYAGGMRDGLKWQPGGAGTDFLTADLDLPMDLGTALAMAVDHENLEEFFSRESCGWCTPCRDGLPWSVKILRALERGEGQPGDIETLEQLCRFLGKTFCAHAPGAVEPLQSAIKYFRDEFEAGIAVKAYESGMTSGNTRAIAGIQPNLLK................................................................................................................................................... 458
4 -47.900[C] KOG2658 NADH:ubiquinone oxidoreductase, NDUFV1/51kDa subunit  ali follow..  17  77................................................................................................................KGAMKRGDWHRTKDLVLKGTDWIVNEMKKSGLRGRGGAGFPSGLKWSVSDGRPSYLVVNADESEPGTCKDREIMRHDPHKLLEGCLIAGVGMRASAAYIYIRGEYVNERLNLEKARREAYEVYIHFGAGAYICGEETALLESLEGKQGKPRLKPPGCPTTVTNVETVAVSPTILRRGPEWFTKLFCISGH-VNKPCTVEEEMSIPLKELIERHCGGVRGGWDAIIPGGSSVPLIPKEDVLMDLGTAAVIVMDKSRLSYFYKHESCGQCTPCREGTGWLWMIMERMKVGNAKLEEIDMLQEVTKQIE-TICALGDAAAWPVQGLIRHFRPELERRIRERAERELLQA.................................................................................................................................................................. 484
5 -26.600[C] COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit  ali follow..  10  173....................................................................................................................................EQMSHLLSACHT---GQEGDSKDFESKA----FHAGLMDDLTREVADLAQIVALLPKGDEDAPLVELGFGTIDTEKPVVLCIGHNVLPGADIVDYLDEEDQVEVCGIDVTRYNEAAKVVGPLSKQLRFIRSGVA-DVIVVDEQCVRTDVLEEALKNRSA-------VIATTDKMCLGLPDMTDEDPDKIVNDLIN-GNIEGALILDPEKVGEVAVKTAMKLAPIRKSLKKLPDID-EIIELASECTDCGWCQRVCPNSLPVMDAVKKAADGDLSKLEEMAIEECYTCGRCEQECERNIPIVSMVTKAGERRVKDEKYRIRAGRGPPEGGKDVALMAKEFLERNMSIGEYRDEDGQTLYEKYGGQFDAKGLVNMGSCVSNAHVSGAAIKIANIFAQKPLEGNFEEIADYILNRVGACGVAWGAYSQKAAAIATGVNRWGRRLFLGRADDEEKWKLKDLRTGEVIDGEPAPEHLLYAAENREEA...... 699
6 -18.200[C] COG1150 Heterodisulfide reductase, subunit C  ali follow..  17  39......................................................................................................................................................................................................................................................................................................................................................................................QACYQCGTCTGSCPSGYRTRLIMRKLQLGLVDEVIKSDLWMCTTCYTCYERCPRGVKIVDAVKAARNLAAKKGYMAKAHRMVAMFVIKTGHAVPINDEIREVRKN............................................................................................................................................. 148
7 -18.200[C] COG1146 Ferredoxin  ali follow..  13  22................................................................................................................................................................................................................................................................................................................................................................LSKVPWWGVDRKEIEWYPTIDYDKCVTCGICFVTCGRRVFDF------DKKEGKVIVARPYNCMVACQTCMNLCPTGAISFPDASYIKKLVAQNKIVKKAFEIIKPLLAEDHLSPKETETKPE................................................................................................................................................. 138
8 -17.800[C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)  ali follow..  16  1.......................................................................................................................................................................................................................................................................................................MIKEIINVVHGTFTQLRSLVMIFGHAFR---------KRDTLQYP-------EEPVYLPPRYRGRIVLTRDP----DGEERCVACNLCAVACPVGCISLQKAETEDGRWYPEFFRINFSRCIFCGLCEEACPTTIQLTPDFEMGEFKRQDLVYEKHDLLISGPGKNPDYNYYRVAGMAIAGKPKGAAQNEAEPIN.................................................................................................................................. 176
9 -16.500[C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit  ali follow..  27  49....................................................................................................................................................................................................................................................................................................................................................................................DESKCVKCYICWKFCPEPAIYI---------KEDGFVAIDYDYCKGCGICANECPTK............................................................................................................................................................................................... 96
10 -16.200[C] KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit  ali follow..  12  1........................................................................................................................................................................................................................MSLTMRIFTASRNGQRLFGSHGARLLAAQRPKDIVEVPKGYVYVNN----KELSMEFADITDRAASTMFFGE---------LLRG------------FAVTLAHIFKEPATINYPFEKGPLSPRFRGE--------------------HALRRYPSGEERCIACKLCEAICPAQAITIEAEERADGSRRTTRYDIDMTKCIYCGFCQEACPVD-AIVEGPNFEFSTETHEELLYNKEKLLCNGDKWESEIASNLQADHLYR............................................................................................................................................... 217
11 -15.000[C] COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB  ali follow..  15  4...............................................................................................................................................................................................................................................................................IWIAVAAVXLLGLAFGAILGYASRRFAVEDDPVVEKIDEILPCGQ--RPYAEAISCNGEKINRCAPGGEAVMLKIAELNVEPQPLDGEAQELTPARMVAVIDENNCIGCTKCIQACPVDAI---------VGATRAMHTVMSDLCTGCNLCVDPCPTHC.............................................................................................................................................................................................. 161
12 -13.900[C] COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit  ali follow..  13  1......................................................................................................................................MVELALPKNSQISEGKVWPK------PDGAKNVREYRIYRWNPDDGQNPRIDTYYIDVDDCGPMVL-------DALLYIKNNIDPTLTLRRSCREGI-------------CGSCAMNIDGTNTLACTKGMEEIKGTVKVYPLPHMPVVKDLVPDLSNFYAQHRSIEPWLKTVS-----------------------------------------------PTPAKEWKQSHEDRLKLDGLYECILCACCSTSCPSYLGPAVLLQAYRERLDNLEDPFRLYRCHTIMNCAQACPKGLNPAKAIAEIKKMMVERR............................................................................................................................................................................. 258
13 -13.500[C] KOG3049 Succinate dehydrogenase, Fe-S protein subunit  ali follow..  13  31..............................................................................................................................................................TAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDL-CGPMVL-------DALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKV------------SKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDES---------------------------------------------QEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYLGPAVLMQAYRERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV....................................................................................................................................................................... 280
14 -13.200[C] COG1145 Ferredoxin  ali follow..  11  1..............................................................................................................................MHHSHHLEIYEKLREK-------NKAPIGLPKTVSGVEKELLLFDEEEAK--IAVHMPFIRFTAEQLAERTGKSLEYVEAKKGTVWKGEKDGQTYYRLFPVIVGFAETPFWPGPGKDPRQEKLARLEHPIMRALPERDTISEKSEILEDAVKLVKERDYIAVGYCPCRVMARLVGEGCRHSIENCIHMGSVGKYMVEHGLGSADEAIEILRQSNREGLVHLTERSKHVATICNCCTIAHSSYLATVDTSRCIACGICMLRCPMKAI--------KAKINREPASVDAEKCLGCGVCVPTCPMEIELVERDELLELPDGMTYVQELLADKGRDP................................................................................................................................................................. 364
15 -13.000[C] COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain  ali follow..  14  3...............................................................................................................................IKTSHLKFKPRINEE----IQNDIMRKAVVMAQERANRQKMVEELGHWEEWREHAKEIRNHVIENLDAYLYQLSEKVIQNGGHVYFAATAEDATNYIKNVAKQKNAKKI--VKSKSMVTEEIGMNHVLEAEGIKV--VETDLGEYILQVADRHQIRKVLAEGVSGCNFAVAETGSVCTNEGNLRLATSLPMERLAPTFGARLTGYNTWLTGPRLAGETDGPEEFHLVIVDNG---RSKMLGSEFREVLRCIRCGACLNTCPAYRQIGGHGYGSIYPGGYEEFKDLPSACSLCTACNQVCPVKIPLANLLLKHRRHIAES.............................................................................................................................................................................. 392
16 -12.500[C] COG0348 Polyferredoxin  ali follow..  14  1......................................................................................................................................MANSPKYAGKEAREKLGWWYANRFLFWRRLTQLSILAMFLSGPYFGVWILKGNYSSSLLLDLIPMTDPLIMAESLATGFMPTMTALLGALIVVV-----LYAILGSRVFPLNIVTDASAWLRRKLEIRQSAKLP---SLRYAILVMILLGSALSGLLLWEWLNPVAALGRALIYGFGATVWLVLAVFLFDLFIVEHGWCGHL--GAAYG----------------VIGAKGLFRIKVEHRQQCDNCMDCYNVCPEPQVLRDPLHAKKSESPLVLSK----DCISCGRCIDVCPEKV--------FIFTTRFNHSVNHSGE...................................................................................................................................................................... 291
17 -12.400[C] COG2440 Ferredoxin-like protein  ali follow..  14  22...........................................................................................................................................................................................................................................................................................................................................................................DPGRPHIKVRPHERPSALALTHICPAKCY---------ELNDKGQVETTSDGCMECGTCRVLCEASGEI............................................................................................................................................................................................ 83
18 -10.900[R] COG1453 Predicted oxidoreductases of the aldo/keto reductase family  ali follow..  13  4........................................................................................................................................RKMPKNGDLGFGCMRLPVKEDGSVDEERATRQVRYAIDQGVNYVDTAWPYHMGESEPFLGRAL--ADGYREKVKLATKKSREDMDKFLNAQLEKTDHIDYYLIHNLSGETWDRIEALNVIDEKAKSDGRIVNAGFSFHGLANDFGLKYAASKGEPLRGGNLARTVPLAIENIWSEADVERTPVEWALRWVWNHPEVTVVLSGMNEEVHIKENLKIASEAYPNSLLVSKVEQKYRQIMKVGCTGCQYCMP-CPSGVNIPECFSIYNSGAVSGGKPGMASQCVQCGQCLEKCPQHIDIPTILESVAEELEGSDLEE.......................................................................................................................................................................... 387
19 -10.800[C] COG1141 Ferredoxin  ali follow..  13  41...........................................................................................................................................................................................................................................................................................................................................................................ILRQKGVYVDEITCIGCKHCAHVARNTFYIEPDYGRSRVIRQDGDAEEVIQEAID------TCPVD--CIHWVDYTELKNLEEDRKFQVIPVVGYPVDHAVATTEKRRRKQKSKNKKSR.......................................................................................................................................... 151
20 -10.400[C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit  ali follow..  11  8...................................................GFGSDGTVGANKAAIKDLYAQGYFSYDSKKSGGLTVSHLRFGENRIRSAYLIQQADFVSCST--------------AYLRSYDLLKGLKPGGTFLLNTRHLPAAMREYIAKNNIQFYTLNAMR-----IAGEAGLGRRINTVMQTAFFVTDILPFEKALADLKASAIATYGKK--------------------------------------------------DMAVAEKNILAMDQTVANLHKVEVPESWANPVLTAEASTATEKPAYVKNILEPVNRLEGDNLTVGDLISNGMVSGAYPP--GTAAYEKRGIALEVPEWISENCTMCNECAFVCPHAAIRPILTNEEEKDGLRYRIQVSPMDCTGCNLCAETCPAKDKALVMKPFEEVAAKENPN............................................................................................................................................................................ 364
21 -10.200[C] COG1142 Fe-S-cluster-containing hydrogenase components 2  ali follow..  15  50.......................................................................................................................................................................................................................................................................................................................................................................................LCHHCAPCAVVCPVNAI----------TRVDGAVQLNESLCVSCKLCGIACPFGAIEFSGSRPLDIPANANTPKAPPAPPAPARISTLLDWVPGIRIAVKCDLCSFDEQGPACVRMCPTKALHLVDNTDIARVSKRKRELTFNTDFGDL................................................................................................ 191
22 -9.690[C] COG0437 Fe-S-cluster-containing hydrogenase components 1  ali follow..  15  55............................................................................................................................................................................................................................................................................................................................................................................HQNVFAYYLSISCNHCPACTKVCPSG---------AMHKREDGFVVVDEDVCIGCRYCHMACPYGAPQYNAEKMTKCDGCYSRVAEGKQPICVESCPLRALEFGPIEELRQKHGTLAAVAPLPRAHFTKPNIVIKPNAN..................................................................................................................... 188
23 -9.390[DR] KOG4739 Uncharacterized protein involved in synaptonemal complex formation  ali follow..  9  4.........................................................................................................................................................................................................................................................................................................................................................................................IQCNHCGIK--------------------NQTKLYLTACVFCQNC--LCKKPLKVDEINKNLRPDLMELFKDPRQLASDLVNELKQVVAFQAKQREIYVKCKNAEAKKDTERFAEARSKHVEKTQEIEKRKKAFLEDNVKLKNAKEEKNQLMARLKELREQPSQNLSVNKRRSNTRTEPPFSKISRTGPPSVMRKASHEFSLNLRDQSTSKILTSTPLSNIDYSRRDHRNRLFGAGLEHPSP. 236
24 -9.260[C] COG1600 Uncharacterized Fe-S protein  ali follow..  16  8...............................................................................................................................KPLDLNQLAQNIKQWGLLGFQQVGI-TDTDLRASEPALQAWLDKQYHGEMAWMARHGMMRARPHELLPGT----------LRVISVRMNYLPANAAFASTLKDPTLGYV----SRYALGRDKKLGEQIQQYCGSLN-------------------FRPFVDSAPILERPLAEAGLG----------TGKHSLILNREAGSFF-----------FLGELLIDLPLPVDQPV----------------EEGCGKCVACMTICPTGAIVEP--------------TVDARRCISCDDCQLICPHNPDLLELFSWSEAQFLKV--EGSAIRRIGHLRWLRNVAVALGNAPWSNAVITALESRKG-EHPLLDEHIEWAIAQQIEKRNACIIEV----------QLPKKQRLVRVIEKGLVRDA........................................................................... 384
25 -9.200[K] KOG2169 Zn-finger transcription factor  ali follow..  7  231................................................................................................................................................................................PFYDVISVLLK--PVELHSSDSPTLKQTKQLQFPFLLTAEHISKISYRADVTPLRYELQLRPQKDDFPLNCY-----RVDDSVVQLPNVIPKTNAEPKRPSRPVNITSNMNRYKKEHT--VAVEWLADKRVWAAGVYF-VNSDILFKRLNQNVSRHRSLEVTKQEVIKKLSGGEDDIAMDRLNISLLCKTRMTTPSRCQDCLQC------------------------FDLLSYLMMNE--QCPVCS-CPYDRLIVDDYFLDMLAKVDKNTTEVELKEDGSYDVIKEEAFCISDDDDDDVVPATVNGTASCSSTNGNGLANEAAKKKPADDDIITLSDDDDEELNRGIMNSLNDSFSPGRHTASAELAAQKTPPQQKKKTKDDDIEIITLDDTPPRPVAASANLPMRQMSQQNQMPVGSSPSGMASTQMGMNEGASKTIRDALN 666
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Bourne PE, Allerston CK, Krebs W, Li W, Shindyalov IN, Godzik A.,Friedberg I, Liu T, Wild D, Hwang S, Ghahramani Z, Chen L, Westbrook J. The status of structural genomics defined through the analysis of current targets and structures. Pac Symp Biocomput. 2004;:375-86.