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Query: [K] COG4742 Predicted transcriptional regulator, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MQSELIDVVFRSQKRRDLLLLLGEEPRTMEDIKVLLDVSPTAILPQIKRLTDSNLVIQKNGSYELTDMGEQVFKKARALVDVLTLVEKDNYWIEHDLGGIPQYLLDKIGEIKDCNLVKADPSQIFEPNTELLEYFASSRYLMVFSSFYRPEFLPLYSKLGRLESEVSLIFTESVLEKFLYNYEKKIRRLATMDNTELCVCKDGVKIAELIVSDRGMMISLFDSQGRFYHEYMYCSEPQAISWARELFDFYESRALRVDGEKSLDSFICTPESGAFSESLLLSLHLast
1 -98.700[K] COG4742 Predicted transcriptional regulator  ali  100  1MQSELIDVVFRSQKRRDLLLLLGEEPRTMEDIKVLLDVSPTAILPQIKRLTDSNLVIQKNGSYELTDMGEQVFKKARALVDVLTLVEKDNYWIEHDLGGIPQYLLDKIGEIKDCNLVKADPSQIFEPNTELLEYFASSRYLMVFSSFYRPEFLPLYSKLGRLESEVSLIFTESVLEKFLYNYEKKIRRLATMDNTELCVCKDGVKIAELIVSDRGMMISLFDSQGRFYHEYMYCSEPQAISWARELFDFYESRALRVDGEKSLDSFICTPESGAFSESLLLSLH 284
2 -21.600[S] COG3373 Uncharacterized protein conserved in archaea  ali follow..  15  5VDGNILRSLNRSELRRKVLFYLLSYRSYLSEISRAVKSDPSNVKGCLESLIGLGLVIVEQSKFKINPEIVEEVRNMKN.............................................................................................................................................................................................................. 100
3 -18.100[K] COG1777 Predicted transcriptional regulators  ali follow..  20  4.DIDNFIAAIENSTRREIIRMLTQERSYALELSRSIGLSQQAILKQLEMLERANLVTSIGFVPS............................................................................................................................................................................................................................ 67
4 -17.800[K] COG3432 Predicted transcriptional regulator  ali follow..  10  32..........RKRGTMEIMFDICEPKCGITRVIYGAGINYVVAQKYLDQLVKVGALNIKTENYEITEKGKLLRTHIEEFIKIRENLYSAKEKVSELLRT......................................................................................................................................................................................... 127
5 -17.400[S] COG3388 Uncharacterized protein conserved in archaea  ali follow..  14  6IFREIINDMDTLKRHISVINVLLEQPIGIIKLSQETGIPEHKIRYSLRILEQENIISPSREGAILTPDFIEHKEQIIA.............................................................................................................................................................................................................. 84
6 -16.700[K] COG4190 Predicted transcriptional regulator  ali follow..  9  59.SYDDLMDTL-TPRVLELIEAIRQEPASINETARVVDRDVKNVHEELSRLAHLGIIFFEEDG.............................................................................................................................................................................................................................. 119
7 -16.500[S] COG4344 Uncharacterized protein conserved in archaea  ali follow..  18  1MSEKEIDELINDYDMLRVLKHFTIHVDYAKNITRYTEIPQMRVREYLKRLKDLGLLDYYTNTYQINKKAEAVLKEI................................................................................................................................................................................................................ 100
8 -16.400[S] COG4860 Uncharacterized protein conserved in archaea  ali follow..  18  13.ELVSIFHAADSEVKRKLLLDLSTGWITLPVIEQKYG---KEGRRALLYLDKIKMIETQ................................................................................................................................................................................................................................. 67
9 -15.600[K] COG1497 Predicted transcriptional regulator  ali follow..  23  2....KALRKKGELTRFQILSEIRQPYVRQKDIADKLGVTVQAVSENIKSLIAEGLVESGSGRYKITRRGEKIKEAAMDLRRYAD........................................................................................................................................................................................................ 86
10 -15.300[S] COG4519 Uncharacterized protein conserved in bacteria  ali follow..  15  1.....MELSPVFARRLYLALLVESERPNVPKLIEKTGWPRRTIQDVIKAMPGIGIELNFVQDYQLSDWGPFDSQWVTERKKDI......................................................................................................................................................................................................... 87
11 -15.200[K] COG3355 Predicted transcriptional regulator  ali follow..  22  26...........SKSDVEVLHILQNGKMTTDDLSQKLNVTKASISKALNNLLDKGLIQREKA............................................................................................................................................................................................................................... 76
12 -15.000[KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon  ali follow..  28  2...........KMKTLFLLIKLAEITVTMRELSRELDVSPQTVLRWLEELKEQGYIHKRESRVELTEKGINLLEKLYE.............................................................................................................................................................................................................. 79
13 -14.500[K] COG1695 Predicted transcriptional regulators  ali follow..  20  2...........DRYAIKALVLLSKKPRTLYQMSKEISVSHGTLMPMIRKLLQERYIDFETRGYHLTERGSRFVESLGKIEEDV......................................................................................................................................................................................................... 81
14 -14.500[K] COG5625 Predicted transcription regulator containing HTH domain  ali follow..  15  12...DLLKAIGLKKNEIRIYRLLKRRGMRIREIQRELGISERSVRTHVLNLYRRGLLKRELVQYTPVSPLEILQKIKEHLMKSIEELER.................................................................................................................................................................................................... 105
15 -14.300[S] COG3398 Uncharacterized protein conserved in archaea  ali follow..  13  175.EEKKVVSALQNATNQRIISEIQNGKNTNLALAREIGVSRATISWYVKNLKETGLIDETRSGYSINPSYEPLIEKY................................................................................................................................................................................................................ 254
16 -14.200[K] COG5631 Predicted transcription regulator, contains HTH domain (MarR family)  ali follow..  12  82...........SPIEILILHSIRDREKKLADICLALDIETHIATYAIRKLEKAGLLTTGKAAVKITAKGAEACAHYAQIRERLLV-----------------------DSTANARPSEETLSELAALLRFMSGAFNQATR................................................................................................................................................ 194
17 -14.100[K] COG2345 Predicted transcriptional regulator  ali follow..  28  13.........GDGDTRRKILLILLEAPVIASDIAEQLQLSTVGVRRHLDNLVEENLAEAA................................................................................................................................................................................................................................. 63
18 -14.100[K] COG1846 Transcriptional regulators  ali follow..  18  41...........TPSEIHTIDAITDEGLLMKELAERLGVTKGAVSQLVDRLEAKALVRRTAHPVVLTDKGREAYRAHADMHAAF......................................................................................................................................................................................................... 120
19 -12.900[K] COG1654 Biotin operon repressor  ali follow..  19  1........MKDTTVPLTLISLLADGEHSGEQLGERLGMSRAAINKHIQTLRDWGV-TVPGKGYSLPEPIQLLDAD................................................................................................................................................................................................................. 70
20 -12.600[S] COG2469 Uncharacterized conserved protein  ali follow..  16  198...........SEVEEQILTMVYTG-VDSVSVESILGVTTEELNKMYDRLVNLGLARVIRKEIELTPRGVALVSEIMK.............................................................................................................................................................................................................. 265
21 -12.400[S] COG4754 Uncharacterized conserved protein  ali follow..  10  18...............LYVMNNIFDGKTDLYQLEKEMEVDIDDLMPIVYTASRLGFVSAESGDIIVTEEGKEYIRA................................................................................................................................................................................................................. 77
22 -12.400[K] COG1733 Predicted transcriptional regulators  ali follow..  21  18........VLCTRWTMVLMRELVAGSTRFNDLRRGVKMSPTLLSQRLKELELAGIVERKIFDYRLTEAGRDLRPVVEAMGF........................................................................................................................................................................................................... 98
23 -12.300[K] COG4738 Predicted transcriptional regulator  ali follow..  14  27...ELLRRLNINRPVALTLACLSKDEISSQRIEMVSGLRQPEVSIAMRYLRENEWVDMREEKYKLTVQMETIIDTIEE.............................................................................................................................................................................................................. 113
24 -12.300[K] COG1510 Predicted transcriptional regulators  ali follow..  14  29........MPSTVGRVLGIIYMNRKPMTLSELSEATGMSKTRMSQVVREMIDANIAEK.................................................................................................................................................................................................................................. 78
25 -12.200[K] COG1378 Predicted transcriptional regulators  ali follow..  10  28...EVLKRLGFRDYEARVATLATRGEATASEIHRVSGVPRNKVYEVLRSLEDRGMIETIKSSFRAIDPESVLEEYKEQLVSAVDTAIRSIRESEDFSTL-------PVWCVRGLAGIKNRAKAMLQRSEEVFVITAKRVYLDMILKIK-------------SPEDITVVTDNAEKFSDLSVKTLELKKEFSGIFNDAVIDGVRYRFELLLISGYESFGVYRAGDELL----VSISLPIIILFQRMIFLGLLAK............................... 259
26 -11.600[K] COG4189 Predicted transcriptional regulator  ali follow..  11  12.KEFDVLKAAASLIRVQILKLLHENGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRRKARKGSQKICFATCDELIVSFRKPETPAASNYIAVAMPLGLYTQSSVTAPCGICSPEGIIGLLDVPDTFMDPDRMKTALLWLTSGFVEYQFPNNAKIQGRNVEE-IEFSMEVSSEV-PGTHSNWPSDITLSVNGKEIGVWTSPGDF................................................................................ 216
27 -11.400[K] COG0640 Predicted transcriptional regulators  ali follow..  17  1............................MNEITMQTQADQPKVSSNLAILSEARLVDSIQMGYRIAP------EKFEDMVDWLDSILH.................................................................................................................................................................................................... 58
28 -11.100[K] COG1414 Transcriptional regulator  ali follow..  12  6LETDDRYRAPALDKGLDILELLASGGLTQAEIAKHLDRSPNEFYRMLDRLVKRGYVTKLDGDYSL---TLKLFGLAQLHAPVRRLASFATPFMRELADRSKQAN--QLAVFDRGSVVVIAQQEAPDY-------WGISIRVGSHISLFDTGSGHVLLAFRSPEEREMMIAAHVKSRDEVNLDQDFYDRLDQIRERGYEMMASAQMAGAYNL-----SAPILGPDGTCVAALTCPYITLVNP--TQTISLLQKTVRDLSKL........................ 255
29 -11.000[S] COG2512 Uncharacterized membrane-associated protein/domain  ali follow..  18  247...........SPELCEVLDIIRGGRITQKDLRSKLDYSEVKVSLMLSELEKRGLIRKLR-------NGR...................................................................................................................................................................................................................... 300
30 -11.000[S] COG4861 Uncharacterized protein conserved in bacteria  ali follow..  16  144...........TPKRAQVVCVLLDAPQPLRAIAASAGVSVGMAKETMDTLRTTGFFEHLGSRRRLVRTDELL.................................................................................................................................................................................................................... 208
31 -10.600[K] COG1321 Mn-dependent transcriptional regulator  ali follow..  22  6...........TDRIEEYLETINQGPAKTKQIAEELNVSSPSVTEMIKKLHSMGFVEYKPQGVELTEKGAEEAVRIKRKHQVLETF...................................................................................................................................................................................................... 87
32 -10.400[P] COG0735 Fe2+/Zn2+ uptake regulation proteins  ali follow..  13  1.....MVTPQLTKNQSLVMGALSDGPMSAYTILDKLRDNGFQVYRALDKLLEYGLVHR.................................................................................................................................................................................................................................. 59
33 -9.910[K] COG2973 Trp operon repressor  ali follow..  11  43LTPDEREALG---TRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAP...................................................................................................................................................................................................................................... 93
34 -9.490[K] COG0583 Transcriptional regulator  ali follow..  13  5LDWDKLRIFHAAAEAGSF-----------THAAQTLHLSQSAISRQVSALEQDPLFHRHARGLILTEQGETLYRTAHDVLMKLENVRSK---------------------------LAESREKPSGRLRVTTTVGLGSGWLIERIQEFVELYPD---------VQLQLILDNEELDLTMRHADCAVR................................................................................................. 147
35 -9.450[K] COG2378 Predicted transcriptional regulator  ali follow..  11  20........MRKASRLFEIIQILRRRPVTAQTIADMLEVTARSVYRDIAALQTMRIEGERGVGYILRPEAIVLALAMVDRSGDAELRQAAKKVSDKIAASLPEPLSKTLSANALHAWGSIAPAPAGIDLATVRRAVRDEERLD.............................................................................................................................................. 171
36 -9.430[K] COG1522 Transcriptional regulators  ali follow..  21  1.....MSKVELDKIDRKILEVLQNGRLTNLEVAERVNLSPSPCLRRIRRLEESGVIRQYAALLDPGKIG....................................................................................................................................................................................................................... 65
37 -9.200[KG] COG1349 Transcriptional regulators of sugar metabolism  ali follow..  20  1........MKPRQRQAAILEHLKQGKCSVEELAQYFDTTGTTIRKDLVILENAGTVIRTYGGVVLN.......................................................................................................................................................................................................................... 59
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;