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Query: [T] COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MINVLIVDDEQIEREGLKLFLKDRPNIHIVGEASNGRQAIEKALETQPDLMMMDIKMPGVDGVQAVKEIKQQLPETEFIMVSAFDTFEYAREVMRYGVKEYLLKPTTKEDVLTALDRIVGEIEQAREEKNDQYKLQQRLEQISSFVQTESILYLLMDHIQDYEWMEWNEWLRTEQEGYAVVFSFHQQGKEIRKTEKQQWHARIKKEIGLQLPKSTVGPFIGHHLPILMLTENENGMTKQEREQVVIQLLHKVKQAVQPAKVKTGVGGIYRLHFFSTSYREALLALDIIYDHKQASYYFYDKNVKIRADEQLPIERENKLIEAIKSGDGEKALQAFDHYVQAILRCSKHPLHDMRKYLQQLFIILGRLLNEMGLHWETAQDFARFSTVHQVTEHGKSEILHIVRTLQEWRTTDEQSLMLLARDYVHDHFREPLTLDDLAKHIGLSPYYVSKLFKERFDLTFSEYVTQLRVEHAKQLLSLTQKSLKEITYEIGYKDPNYFSRVFKKLTGKSPSDYRKSINGLGPKEDTLNGELast
1 -135.000[T] COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain  ali  100  1MINVLIVDDEQIEREGLKLFLKDRPNIHIVGEASNGRQAIEKALETQPDLMMMDIKMPGVDGVQAVKEIKQQLPETEFIMVSAFDTFEYAREVMRYGVKEYLLKPTTKEDVLTALDRIVGEIEQAREEKNDQYKLQQRLEQISSFVQTESILYLLMDHIQDYEWMEWNEWLRTEQEGYAVVFSFHQQGKEIRKTEKQQWHARIKKEIGLQLPKSTVGPFIGHHLPILMLTENENGMTKQEREQVVIQLLHKVKQAVQPAKVKTGVGGIYRLHFFSTSYREALLALDIIYDHKQASYYFYDKNVKIRADEQLPIERENKLIEAIKSGDGEKALQAFDHYVQAILRCSKHPLHDMRKYLQQLFIILGRLLNEMGLHWETAQDFARFSTVHQVTEHGKSEILHIVRTLQEWRTTDEQSLMLLARDYVHDHFREPLTLDDLAKHIGLSPYYVSKLFKERFDLTFSEYVTQLRVEHAKQLLSLTQKSLKEITYEIGYKDPNYFSRVFKKLTGKSPSDYRKSINGLGPKEDTLNGE 530
2 -43.100[KT] COG4565 Response regulator of citrate/malate metabolism  ali follow..  25  4LIDVLIVEDETSIADVHSFYLKQTARFRPVGVAQSINEARNMVRILKPKLIFLDNYLPDGRGIEFLKELTHQPQAPDVIFITAASDMETVREAVRCGVFDYLLKPIAYDRVQNSLERYLKYISSLRANDSVN---QRHVDELFNFQAKTDQLDGLPKGIDELTLIKIQEIYHHEPQAAYTAELLGQ........................................................................................................................................................................................................................................................................................................................................................ 186
3 -37.600[KT] COG3279 Response regulator of the LytR/AlgR family  ali follow..  30  1MLRVIIVDDEQPAREDLRERLNEEHGIEIVAECSNALEAIPAIQRLQPDVVFLDIQMPRINGLELASMLNPESMP-HIVFVTAYD--EYAIRAFEEHAFDYLLKPLDHQRLAKTLTRLSRDLIVKNNLHKVIKPILRHI....................................................................................................................................................................................................................................................................................................................................................................................................... 136
4 -36.400[TK] COG4567 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain  ali follow..  20  17..TLLLVDDDKPFLQRLARAMESR-GFQVT-TAESVEEGIAAVKTSAPAYAVVDMRLGDGNGLNIIEAIRSRRADTRAIVLTGYGNIATAVNAVKLGAIDYLSKPADADEVFAALTRRPGEKVAPPENPMSADRVRWE........................................................................................................................................................................................................................................................................................................................................................................................................ 150
5 -35.900[TK] COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain  ali follow..  16  1MYKILIADDHPLFREAIHNVIADGFPGSEVMETADLDSALGLTQEHDDDLILLDLNMPGMHGLNGLMNLRNEAPTIPVVIVSAEQDKQVVLQAITYGAVGFITKSSPRAQMTEAIEQILNTQKSSPRRSGHEEHGISPELLQALTRKQLLVLERMTKGESNKQIAYNLDIAETTVKAHVSAI............................................................................................................................................................................................................................................................................................................................................................ 194
6 -32.900[K] COG2207 AraC-type DNA-binding domain-containing proteins  ali follow..  16  147........................................................................................................................................................................................................................................................................................................................................................................LRGLAASCLKAVPKGHLGETLRREADVLRLLSDLWDTVSDGIGPAAGQTAEADAMPSEDFSRILNAAFAGGHQVNRLADTLNISERTLQRRMRDHFGITASEWLHHKQMQHALYLLQNGGKSIGETAYLCGYRHVSSFTQAFRQYFGSTPAETKKENR............ 305
7 -32.700[F] COG2169 Adenosine deaminase  ali follow..  19  90............................................................................................................................................................................................................................................................................................................................................................................................................................RHAEMVASACRFIETAETQPSLEEIANVVKASPAHFHRVFKAFTGLTPKAYADAHRAGRMRAALDMPQIRVTDAIYDAGYNSSSRFYEASDRILGMTPKAYRAGGKDAD......... 198
8 -31.000[T] COG4566 Response regulator  ali follow..  18  26...VVVVDDDAAVREGLSELI-LSAGFQPVSFASTQELLNAVDILDGPGCLILDVHMPGESGLDLQHHLAERGIGKPIIFLTGRGDIPMTVQAMKDGAVDFLTKPVSDRTLLDAVIAAIALDQTQRAEAIVVKRNVERLKTLTR--EREVLREVVTRGRLNKQIAFDL.......................................................................................................................................................................................................................................................................................................................................................................... 188
9 -30.300[T] COG3707 Response regulator with putative antiterminator output domain  ali follow..  15  15.LTILVIDENAIRASIIEEGL-REAGYQRVTVIHEVNGVARTIETLQPDVIFIDLENPNRDMMEHLFQLTRTVG-RPIAMFVDRSDTASIEAAVEAGVSAYVVDGLKKERVKPILDMAVSRFNAFSRLQRELADAKSALEERKVIERAKGIL-MKMRGLSEEEAFALLRQTAMNEKKKISEIA........................................................................................................................................................................................................................................................................................................................................................... 193
10 -27.900[K] COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain  ali follow..  19  215........................................................................................................................................................................................................................................................................................................................................................................................................................RIEARDPELAAAIRLMERTLERPMTVAALARRLSVSQRKLETLFAKGLSTSPGAYYLRLRLQVAHRLVRDTGIPMRDIALRCGFDSLSAFSRAYRREYRTSALKMRSARGAGVTPDASDKG. 335
11 -27.300[TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain  ali follow..  22  4..HVLVVEDDLVTRSKLSGYFQNE-GYQVT-EAESGAQMREALELNDIDLVLLDINLPGEDGLLLTRELRSQS-EIGIILVTGRTDSIDKIVGLEMGADDYVTKPVDLRELQVRVKNLLWRISLAQRERITDKHDDKLVH...................................................................................................................................................................................................................................................................................................................................................................................................... 138
12 -27.200[T] COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains  ali follow..  14  8..HLLLVDDDPGLLKLLGMRLTSE-GYSVV-TAESGQEGLRVLHREKVDLVISDLRMDEMDGMQLFTEIQKVQPGMPVIILTAHGSIPDAVAATQKGVFSFLTKPIDRDALYKAIDEALEQSAPATDDSW--------------------RNAIVTRSPLMLRLLEQARMVA--------------------------------------------------QSDVSVLINGQSGTGKEIFAQAIHNASPRSNKPFVAINCGALPEQLLESEHARGAFTGAVSNREGLFQAAEGGTLFLDEIGD------MPAPLQVKLLRVLQERKVRPLGS---------NRDIDIDVRIISATHRDLPKAMARGEFREDLYYRLNVVSLKIPALAERTEDIPLLANHLLRQSAQRHKPFVRAFSTDAMKRLMTAWPGNVQLVNVIEQC-ISDALVEQALEGENTATFAEARNQFELNYLRKLLQITKGNVTHAARMAGRNRTEFYKLL--SRHELDANDFKE............... 445
13 -26.100[NT] COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain  ali follow..  19  4.IRVLSVDDSALMRQIMTEIINSHSDMEMVATAPDPLVARDLIKKFNPDVLTLDVEMPRMDGLDFLEKLMRLRP-MPVVMVSSLTG-EVTLRALELGAIDFVTKPQLREGMLAYSEMIAEKVRTAARARIAAHKPMAAPTTLKAGPLLSSEKLIAIGAST.................................................................................................................................................................................................................................................................................................................................................................................. 165
14 -25.200[T] COG4999 Uncharacterized domain of BarA-like signal transduction histidine kinases  ali follow..  14  13..RLAYVEPNSAAAQCTLDIL-SETPLEV-----VYSPTFSALPPAHYDMMLLGIAVTFREPLTMQHERLAKAVSMTMLALPCHA-QVNAEKLKQDGIGACLLKPLTPTRLLPALTEFCHHKQNTLLPVTDESK............................................................................................................................................................................................................................................................................................................................................................................................................ 140
15 -24.000[KT] COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain  ali follow..  18  72..TILIVDDSPDNIAFMSQGLAQYYR---IKAARSGKVALEILAQYPIDLVLLDIVMPEMSGYEVINQIKHNTEHIPVIFLTGKSNPEDEQLGFELGAVDYVFKPVSIPLLKSRVHTHLQNKRSKDILLNQNDYLETEVLRRSGELDRMQDAVV........................................................................................................................................................................................................................................................................................................................................................................................ 222
16 -22.500[T] COG0784 FOG: CheY-like receiver  ali follow..  20  7..RVLVVEDESMIAMLIEDTL-CELGHEVAATASRMQEALDIARKGQFDIAIIDVNLDGEPSYPVADILAER--NVPFIFATGYGSKGLDTR---YSNIPLLTKPFLDSELEAVLVQISKEV........................................................................................................................................................................................................................................................................................................................................................................................................................ 120
17 -22.100[T] COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain  ali follow..  14  140..SVLVVDDARTARSGLVEIL-ERQNFKVS-EAHSGNRALEILSQDSIQLVITDYHMPDMDGYELTRRIRDSRSDLRVIGISSSTDRLLSASFLKAGASDFVYRPFVPEELQCRIDNNIETL--------------KQLKRLRELAERDHLTGLPNRRSFFERTRALMDVINDNDESGAVAILFKKINDTLGHDAGDRALKKLAELLQGMCDEQRHIPARLGGEEFAVFLRGLDARAAYAFCEELREQVEKNGRQLSALTISLGVVEIEKGEPFDNQLNAADQLLYLAKANGRNRVYSDIMIQEGLQK.............................................................................................................................................................................................................................. 440
18 -20.800[T] COG3947 Response regulator containing CheY-like receiver and SARP domains  ali follow..  21  1..........................................MIQHKPDLIFLDINLPDINGIDFAEQVQSILPEVHIVFITAYDE--YAVKAFELNAIDYVMKPVQRDRLNRTINRITDRKTVEPLRSQT............................................................................................................................................................................................................................................................................................................................................................................................................... 87
19 -14.900[KT] COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  8  44.LELLHDARSRSLFETLKRDIASVPETEVVSVEIELHNPWDFEEVYACLHDFARGYEFQPEKEDYLIHITTGTHVAQICWFLLAEARYLPARLIQSSPPRKKEQPRGPGEVTIIDLDLSRY-----------NAIASRFAEERQQTLDFLKSGIATRNPHFNRMIEQIEKVAIKSRAP-------------------------------------------------ILLNGPTGAGKSFLARRILELKQARHQFSGAFVEVNCATLRGDTAM-KGAFTGARESREGLLRSANGGMLFLDEI-------ELGADEQAMLLKAIEEKTFYPFDRQVSSDFQLIAGTVRDLRQLVAEARINLWTFTLPGLRQRQEDIEPNLDVERHASLTGDSVRFNTEARRAWLAFATSPQATWRGNFRELSASVTR--SGRITLDVVEDEINRLRYNWQE--LLGAEAENIDLFDRMQLEHVIAICRQAKSLSAAGRQLFDVSDADRLRKYLARF-GLTWEAVQDQHSSS.......... 532
20 -11.400[TQ] COG2508 Regulator of polyketide synthase expression  ali follow..  7  163VEKQRRLAAEEKTAGRLDRALAAHTSMLEHVLSDGSVSSLMAGRLLPDPLIVVDFTTNQI---ESLSTVASQMVPILLDTGSIRLKVAARMETLMVDHVGALIIFSNPATSGEMLDSAKFALSVQMMRSFLRFRFETR-------TQSELFFEVVERRWRDADISQRATRLGLDFSSSQQMIVV---DFPQKAKAFGGGSVDVQHTISRVMQQVGLAANLAIEGGLVCLMPYETTRRREKTGKIMQRIADELKRYFEEAPIVVASTRCAGLDDYPSAWDRCNRMISIGRSFGLTGAVSTQD-------------------------------------------------------------------------FGPLPMLVSAADVSDVRSFVRESIGAMAEH----DREHQTPYLETLSVYLQES-----RAQACADRMGLHVTTLRYRLAR------IQELFGIDVETPDKRFAELAIRLHRVIDNPVFGE.................................... 600
21 -10.000[KT] COG3835 Sugar diacid utilization regulator  ali follow..  12  6.....................................QLAQQIVDRTMAIIGYNINVMNQAGVIIGNRIGQVHDGAILALKHGDSVELTAESCVALGVKPGINMVLRQQQVVGIV-RDFANLVKMSAEMIIEQAALVEQLQWDRRHREEFISAWIHNTLSAAELDAWAARLSIDLSKPRVAVVI-----AFRQPKSGQSLDQIRQVVELLEHPERDNLVAVVSMQEIVVLCRTPEHWTSEYESLRIDKLMARLKAYDITGYDIALGQFINPNAIHLSYQSAKQVLRIQVRQPEKQKHLYEEL---------------RLPVLLLPLNEGWQGEQWRRVMQELQT-----------------------------------------------------------------QDKSGQLVKTLKGLFAAN-----NLNLCAQQLFIHRNYRLEKITEITGIETNSLLGLAELYIAYQLTS..................................................... 377
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Rychlewski L, Zhang B, Godzik A. Fold prediction by a hierarchy of sequence, threading, and modeling methods. Protein Sci. 1998 Jun;7(6):1431-40.