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Query: [S] COG4906 Predicted membrane protein, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDRKSLIITMSVLLGLNSAILADYLGVHIPLARQIFGFIALTFFPGYLLLKIFRTRLESFSEKIFLSVALSISVVMLMGIFANFVYPLLGVEKPITLLPILLTFNVVTLGLLAVEQARTVPMLNTRRQIRIAKWDLFFALLPVWSLIGAYLFSHYGDNSGLLLLYFVIALTPLVFLKSKNFNRTFAIWSIAISLMWSTVFGVSWNYIWGYDINGEYYYANLVLARGIWSISTYDQYNTIASVNILGPVYSLILNMWIVPIFKIIYPLVFSLVPVILLKAYERLLGNKIWAELSVLFFMFFFQFFVSNMALARMMIVEVYLALLAYATIRKINPLFLILFLASLAVSHYGTAYLTMFALLTLPLIRVLENEQRISNKLIAVFWVVTLLWYAYVGGGFQFNNLVIIGYQTLLMLKDLFNPQYSQGLELIVAKMTFMREIAKLINLFAQGLISIGVLTVLNRLIRGRKVKHLEFYALSFAFFAYDIAGIVVPYFSNRMNVNRLYHLTQFFIAPYLLIGFDSVKRIMNNLSKNRHTLPLKNSVEIAGVFLVVYFIFTSGWTLVIANDPKPPMWLEKVDGPYWSLSEISGGKWIAEYRYDSLKIYSDQYRALLFLGLINQNINEVSFRGEEKISNFPKREAYAYLGKTSVREKKILVINQKYLGTIKEFYYLPIYNKSIFEGLWTSNKIYSSQDVAIYKILast
1 -154.000[S] COG4906 Predicted membrane protein  ali  100  1MDRKSLIITMSVLLGLNSAILADYLGVHIPLARQIFGFIALTFFPGYLLLKIFRTRLESFSEKIFLSVALSISVVMLMGIFANFVYPLLGVEKPITLLPILLTFNVVTLGLLAVEQARTVPMLNTRRQIRIAKWDLFFALLPVWSLIGAYLFSHYGDNSGLLLLYFVIALTPLVFLKSKNFNRTFAIWSIAISLMWSTVFGVSWNYIWGYDINGEYYYANLVLARGIWSISTYDQYNTIASVNILGPVYSLILNMWIVPIFKIIYPLVFSLVPVILLKAYERLLGNKIWAELSVLFFMFFFQFFVSNMALARMMIVEVYLALLAYATIRKINPLFLILFLASLAVSHYGTAYLTMFALLTLPLIRVLENEQRISNKLIAVFWVVTLLWYAYVGGGFQFNNLVIIGYQTLLMLKDLFNPQYSQGLELIVAKMTFMREIAKLINLFAQGLISIGVLTVLNRLIRGRKVKHLEFYALSFAFFAYDIAGIVVPYFSNRMNVNRLYHLTQFFIAPYLLIGFDSVKRIMNNLSKNRHTLPLKNSVEIAGVFLVVYFIFTSGWTLVIANDPKPPMWLEKVDGPYWSLSEISGGKWIAEYRYDSLKIYSDQYRALLFLGLINQNINEVSFRGEEKISNFPKREAYAYLGKTSVREKKILVINQKYLGTIKEFYYLPIYNKSIFEGLWTSNKIYSSQDVAIYKI 695
2 -14.200[S] COG5427 Uncharacterized membrane protein  ali follow..  6  1.................................................................MEFGVVARWWVFFGVLLVAGLPVA-LLPDAPDRGASVAMPLSLVVVTLATL-----------------------------WVGQVAYGQLVVGGVFVAVLAAAAWLARGGVEIPRKPLLEVVGVFTVAFVFLIVVRAWADGVQGGEQFLDFGLLQALDRAGQW---AGERVVYYYGGQLMASIGAHLTDTAPRFAYEPALAGVYAMGCTAAYGLASTIAAGNGAGVLGAFAFLNEFPLFAYLNGDLHAHMVSVPVLFVAVAVGQRRRRWALLWGGFPVAGAAILTV-TVFGVAALAVALADPAPATLLPTGVQRAAVGGVLAVVIAWPFVQNVLLLAAFGAYFVSRVATSVAGWVVAAAAAGAAVAVAVAVGPVVGGVGITAVVLVGPVLGAAWWLRRRNAAGVECVLVAAGAGLVVLVEYV--YLADAASYERFNTVFKVYAQVWALWSVAGGVALAGVSERRAST--GGLGAVFVVGLVVAASVYGGLAVTTHAANADDASLDALEYAGNAHPGEAAAARWLGDRRRGTRIVAAPGVDPYTWQNPAASLSGVPTVAHSQAAWEQRVDDIGVVYETTDAASRAAILEKYDVTYVWVGPVERARYEIPDLSADPGIEPVHRTPAVTIYRV 779
3 -13.900[S] COG4743 Predicted membrane protein  ali follow..  19  34.......LLLVAGLVILTDIFVLTPALSGSFLRTFLGILLVLFLPGYALTGALAKKDLEGIERALLSVGLSIAVVPLMGFGMNYT--------GIREVPVLIGLSTFTLLMCGVAYYR-RLQLPEAEAFEVPFKASILALKAEILEKQGSRADRALSILLVILVLTSLGSLAYVIGNPREGESFTEFYIL......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 211
4 -13.600[S] COG5617 Predicted integral membrane protein  ali follow..  11  1...................................................................................................................................................................................MKRKLYYLTLATISVIEYIPLYLAPSPALQINGNGHLFKVHKLMTSGWWIEDWYAGYPFLRPLSYLTAGVLGKVLGSDTKGYAATLMLTSFLGALALHHYLKST---GREPCISPLIFLLFPWHLTVS-GNFPRANAIHLAPLFLLSLYRERYLIASALGISIVALTHYSILPLLIITGILILWDDLRTMTALGNGIKVLGAVIGLTSFWY---------------------VPFLFDKKWVEFWNISENKALFKSFSLNPTLLKSPFGILLILLLLIFAIFAIKNLVDRKKVILAGLYLYLSLGFYSSFPLLSIVPPYRWFDLEALIIP---LLIGESLKRV-----------QRKSMVALVIIPFTVLAFMNV............................................................................................................................................. 356
5 -13.200[O] KOG2292 Oligosaccharyltransferase, STT3 subunit  ali follow..  10  16.....................................................................................................................................................................................SSLITFAILLIAWLAGFSSRLFASIIHEFDPWFNYRATAYMVQNGWFDERAWYPLGMITSGGIHWLLHVLNIPVHIRDICVFLAPIFSGLTSISTYLLTKELWS-AGAGLFAASFIAIVPGYISRSVAYDNEGIAIFALQFTYFLWVRSVKTAAAALSYFYMVSAWGGYVFIINLIPLHVFVLLIMGRYSPRLLTSYSTFYILGLL-------------FSMQIPFVGFQPIRTSEHMAALGVFVLLMAVATLRHLQSVLSGGLLVGVGVFVAVVVLTMLGVVAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTTWFSFFFDLHILVCAFPVGVWYCIK----------QINDERVFVVLYAISAVYFAGVM............................................................................................................................................. 404
6 -12.800[R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation  ali follow..  10  21.....................................................................................................................................................................................KIPLKVLILICIAVASVSSRLFSSIIHEFDPWFNFRASKILVEQGFFDERSWYPLGMVTSGIIFKVLHLLRINVNIRDVCVLLAPAFSGITAIATYYLARELKS-DACGLLAAAFMGIAPGYTSRSVA--NEAIAITLLMSTFALWIKAVKSACTGLLYFYMVTAWGGYVFITNMIPLHVFVLLLMGRYTSKLYIAYTTYYVIGTL----ASMQVPFVGFQPVSTSEHMSALGVFGLLQLFAFYNYVKGLVSSKQFQILIRFALVCLVGLATVVLFALSSTGVIAPWTGRFYSLWDTNYAKIHIPIIASVSEHQPPTSSLFFDLQFLIWLLPVGVYLCFK----------ELRNEHVFIIIYSVLGTYFCGVM............................................................................................................................................. 409
7 -12.000[O] COG4346 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  10  172.....................................................................................................................................................................................................................................................PFLGKDIIALGMLFYWRIPGIIEHALIVIIVTLVAYKITKSYLASSIAATFAALDPLLFATGIVAMLDIHVAFFIALFMLFLALDRIRLSGIALGLAAA-TKLSGAFAFPILWFKILKEKDLKEYLISGLVLPMVSFLIPEITIIKAIGFIPWLEEFIASFSWHLSFKGEHPSEAPFWMWFVSLKPFPFHFDPDVYAVTDPILMISMIVFVFAVPYVSLRRKGLSEIFW---MFWSIIAFFALQYILGG-----QFIFYATPLIPPGAV---ALGVISYEIIKWEYFERSLRIYLNYLRSIAKPLK................................................................................................................................................ 472
8 -11.500[O] COG4745 Predicted membrane-bound mannosyltransferase  ali follow..  9  15..........................................................................................................................................................................................AVVAVTAAALLARLWALGWRVAHQDEARVADWTLQYMDLGAWQ--YRPIIHGPFLPHVNGVVFD-VFGAT-DFTMRLVVAVVGGLLPLTAWLYRTRL--SDVEVGALAVLLAANPVVLYYSRFMRNDLLLAGFMFTAVGLFVHRARYLYASAVPFALAFTTKENSLLYPLCWLGALALVTDDR-WRAKAALAGSALTAAVIVVSFYAPKPDLYRLFEQPGRAPAVLEAATIGTYHEFADLWASTSTVAHSYVAFLSHDLSVLSVAAVVGYLANRYATETPRPLVSFAFYWGVFSVLGYPAVVDI--------AAAWTAVNALVPLAIPAAVGVGAVVRYGRRGAAAGDTAAVRLAVTVLVVSAAGM............................................................................................................................................... 403
9 -11.500[M] COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family  ali follow..  8  2.....................................................................................................................................................................................KSVRYLIGLFAFIACYYLLPISTRLLWQPDETRYAEISREMLASGDWVPHLLGLFEKPIAGYWINSIGQWLFGAN-NFGVRAGVIFATLLTAALVTWFTLRLWRDKRLALLATVIYLSLFIVYAIGTYAVLDPFIAFWLVAGMCSFWGKSAGFLLLGITCGMVMTKGFLALAVPVLSVLPWVATQKRWKDLFIYGWVISCVLTVLPWGLAIAQREPNFWHYFFWVEHIQRFALDDAQHRAP--------------WYYVPVIIAGSLPWLGLLPGALYTGWKNRKHSATVYLLSWTIMPLLFF---------SVAKGKLPTYILSCFASLAMLMAHYALLAAKNNPLALRINGWINIAFGVTGIIATFVV................................................................................................................................................ 363
10 -11.000[P] KOG4505 Na+/H+ antiporter  ali follow..  11  16....AIIGGFTSLFMLCSLIIKEKLFLGEATMATATGLIF-----GPYVAKLFVPTSWGNTDYITEELAVLLVVEVFAGAELPRAYMLRHWRSMFVMLLPVMIFGWLVSTGFMYALIPRLSF--------LESLAIAACITATDPVLASSIVGKGKFARRV-------GHLRNMLLAESGCNDGMAIPFLYLAIYLIIEKP---------------------------HAGRDWVCIIILYECTFGCVLGAIIGVIARKMIKFSFLVFYFVLALFCGGIGTIIGVDDLLVSFCAGAAFSWDSWFSK-----KTEESHVSNVIDLLL-----NLSFFVYVGAIMPWPQFHMPHMDLSVWRLVVLAICILIARRIPAVLLFKSFVLFAGHFGPIGVGALYTCLVARAELEVHSTVPEPNDAIENPEIPNWYCIQVMWPVVCFL--VLSSIIVHGSSIAFFMLGKRINTLALS................................................................................................................................................................................................................................. 446
11 -9.860[MU] KOG2515 Mannosyltransferase  ali follow..  9  16...........................................................................................................................................................................................WTFSILAVLRLTSASFRVID---DEVYNYWEPLHYLLYGYWEYSPEYAIRSWFYIALHAVPGFLLSRLHVFYFIRGVLACFSAFCETNLILAVARNFNRA-VALHLTSVLFVNSGMWSASTSFLPSSFAMNMVTLALSAQLTKRTVKVVSFITIGAVIGWPFSAALSIPFILLELVDLKGRFRHLFCRWFKAIFVALLITGICITVDSLFYHRIQFVAWNIV--KYNVLAKDGRGPDIYGTE---FANLSLQHNIVLWFAMACGPLVLLAAFTNWINLDSFLDLSSVISPFYIWLFIFIIQPH-------ERFMYPIYPVLCLAAAIGLDMSLKLMIQILSSINETVRSKFPVRFVVLCVYAIIGCL............................................................................................................................................. 388
12 -9.650[S] COG4984 Predicted membrane protein  ali follow..  16  294.............................PLF-----ILLIIFCTGLLLITLFDEQDLIYPSILFLIIALAIDMFMATGFILYFIFFLFDGENDLY-------LALMAILSVFLYQLRSSNWLRF-----LIASLFIIAFLVYIGFFDLRWYAYYEEHLGQFVLSIILGGLLLYYFFSLSEERPYTIKLLPIAWAMLLV-----------GLAMNLDIFNRW--------TFLDTAQQTPEMSDLNDWFHVITGLTSDTWLIKSLHLLISITPIIFFVLISRRFELTKFLYASVLLTLLALCLGF----IAVNETLACISLLLLAYLSVSRVLFALALLGVIMNLSYY---YLLSIPLLHKSFLL---------MGVGIVLALVTF--VLLRYNKAPQATLQAESHNTFQ............................................................................................................................................................................................................................................................................................. 651
13 -9.190[U] KOG1278 Endosomal membrane proteins, EMP70  ali follow..  11  317......SVIVILLSSVVMHSLLRALKSDLARYNELNLDNEFHEDSGWKLGHVFRTPSKSMLLSILVGSGMQLFLMVMCSI----FFAAVGLVSPVSRGSLPTVMFVLYALFGFVGYASMGVYKFFRGPYWKANMILTPILLPGAIFLLIVIMNFF-RSLFFIILLWFLVSVPLSFAHKQCNWDEHPTKTNQIARQIWYLRTAQATLIAGIFSFGSIAVELYFIYSSLWFNKIFYMFGFLLFSFLLLTLYYSLCLENWLWQWRSFII---LGCSIYTFIHSILFTKFKLGGVITVVLYLGYSLIISALCCVVTGAIGFFSSMFFIRKIYSAIK........................................................................................................................................................................................................................................................................................................................................................................... 670
14 -9.060[O] KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase  ali follow..  9  66.......................................................................................................................................................................................VMPVIFTALALFTRMYKIGINNHVVWDEAHFGKFGSYYLRHEFYHDVH-----------KMLVGLSGYLAGYNGSWDFRLFNASFSALCVPLAYFTAKAIGFSLPTVWLMTVLVLFENSYSTLGRFILLDSMLLFFTVASFFSFVMFHNQITGISLGCTISVKMVGLFIITMVGIYTVIDLWTFLADKSMSWKIIVPFCIFLLCFKIHFD.............................................................................................................................................................................................................................................................................................................. 309
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. Discovering new genes with advanced homology detection. Trends Biotechnol. 2002 Aug;20(8):315-6.