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Query: [I] COG4982 3-oxoacyl-[acyl-carrier protein] reductase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst APVVPSGPRPEDISFGAADATLALIALSAKMRLDQIEEMDSIESITDGASSRRNQLLVDLGSELSLGAIDGVAEADLAGLRSQVTKLARTYKPYGPVLSELINDQLRSALGPSGKRPGVIAERVKKIWELGDGWVKHVTVEIALGTREGTSVRGGPLGNLNEGALADVDSVDKAVDAAVASVAARHGVVVALPSAGSGGSATVDVAALSEFTDQITGHDGVLASAARLVLGQLGLDGPVTAAPATTDTGLIDLVTAELSTDWPRLVAPVFDVKKAVVFDDRWASAREDLVRLWLNDEGEIEAQWSHLSERFEGAGHVVATQATWWQGKSLAAGRQIHASLYGRIAAGAQNPDRGLYSSEIAVVTGASKGSIAASVAARLLDGGATVIATTSKLDEERITFYRALYRDHARYGAALWVVAANMASYSDIDALVEWIGNEQTESLGPQSIHIKDAQTPTLLFPFAAPRVIGDLSEAGARSEIEMKVLLWAVQRLIVGLSKIGTERDVASRLHVVLPGSPNRGMFGGDGAYGEAKSALDAVVSRWHAESSWAARVSLAHALIGWTRGTGLMGHNDVIVSAVEEAGVTTYSTDEMAAMLLDLCNAESKVAAAGTPITVDLTGGLGEVDLDMAELAAKAREDHAAQAAEDEATEASEVAGTIAALPSPPRGYTPASPHWDDLDVDPADLVVIVGGAEIGPYGSSRTRFEMEVAGELSAAGVLELVWTTGLIRWEDDPQPGWYDTESGELVDESELVERYHDTVVQRCGIREFVDDGTIDPDHAYPLLVSVFLDKDFAFVVSSEADARAFVEFDPEHTVIRPVPDSSDWQVIRKALast
1 -230.000[I] COG4982 3-oxoacyl-[acyl-carrier protein] reductase  ali  100  1APVVPSGPRPEDISFGAADATLALIALSAKMRLDQIEEMDSIESITDGASSRRNQLLVDLGSELSLGAIDGVAEADLAGLRSQVTKLARTYKPYGPVLSELINDQLRSALGPSGKRPGVIAERVKKIWELGDGWVKHVTVEIALGTREGTSVRGGPLGNLNEGALADVDSVDKAVDAAVASVAARHGVVVALPSAGSGGSATVDVAALSEFTDQITGHDGVLASAARLVLGQLGLDGPVTAAPATTDTGLIDLVTAELSTDWPRLVAPVFDVKKAVVFDDRWASAREDLVRLWLNDEGEIEAQWSHLSERFEGAGHVVATQATWWQGKSLAAGRQIHASLYGRIAAGAQNPDRGLYSSEIAVVTGASKGSIAASVAARLLDGGATVIATTSKLDEERITFYRALYRDHARYGAALWVVAANMASYSDIDALVEWIGNEQTESLGPQSIHIKDAQTPTLLFPFAAPRVIGDLSEAGARSEIEMKVLLWAVQRLIVGLSKIGTERDVASRLHVVLPGSPNRGMFGGDGAYGEAKSALDAVVSRWHAESSWAARVSLAHALIGWTRGTGLMGHNDVIVSAVEEAGVTTYSTDEMAAMLLDLCNAESKVAAAGTPITVDLTGGLGEVDLDMAELAAKAREDHAAQAAEDEATEASEVAGTIAALPSPPRGYTPASPHWDDLDVDPADLVVIVGGAEIGPYGSSRTRFEMEVAGELSAAGVLELVWTTGLIRWEDDPQPGWYDTESGELVDESELVERYHDTVVQRCGIREFVDDGTIDPDHAYPLLVSVFLDKDFAFVVSSEADARAFVEFDPEHTVIRPVPDSSDWQVIRKA 829
2 -41.100[IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali follow..  15  3..................................................................................................................................................................................................................................................................................................................................................................KLTGKTALITGASQG-IGEGIARVFARHGANLILLDISDE------IEKLADELGGRGHRCTAVKADVRDFASVQAAVARA--------------KETEGRIDILVNNAGVCRLGNFLDMSEDRDFHIDINIKGVWNVTKAVLPEMIKRKDG-RIVMMSSVTGDMVADPGETAYALSKAAIVGLTKSLAVE-YAQSGIRVNAICPGYVRTPMAESIARQSNPDDPEPLRRLADPLEVGELAAFLASDESSYLTGTQ---NVIDGGSTL............................................................................................................................................................................................................... 255
3 -40.700[I] COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH)  ali follow..  14  4...................................................................................................................................................................................................................................................................................................................................................................LSGKRILVTGVASKSIAYGIAQAMHREGAELAFTYQNDK------LKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKV--------------WPKFDGFVHSIGFAPGDQLDGTREGFKIAHDISSYSFVAMAKACRSMLN----PGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANA-MGPEGVRVNAISAGPIRTLAASGRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEV---VHVDGGFS................................................................................................................................................................................................................ 252
4 -38.100[R] COG4221 Short-chain alcohol dehydrogenase of unknown specificity  ali follow..  19  1...............................................................................................................................................................................................................................................................................................................................................................MSESLQGKIAVITGAASG-IGLATTEALLEQGATVVMVDWNE--------KALNDLAAKLGERAIPQVTNLLDADSCNAMIPEILGK--------------VDHIDILYCNAGTYIGGDLTETTEAIDKMLNLNVNAVMKNVQAVVPHMSERKTGD--IIVTCSIAGHFPTYWEPVYSGSKWAITSFVQGMRRQ-MIPHGVRVAQVSPGPVVSALLADWPEENLRKAKESG-SLIDASEVADAVVYMLTRKRTVTIRDMLV---LPTNFDRV.............................................................................................................................................................................................................. 243
5 -37.800[R] KOG0725 Reductases with broad range of substrate specificities  ali follow..  14  2......................................................................................................................................................................................................................................................................................................................................................................SCALVIGATST-LGKAVVRRLAFTGYKVAAAADCPNS-----VGKVAEDNIKVGGDVTAFSLDVANAEHRKELITKV--------------AEKLGGLDTLIIVPPQNEVGEIIETSEDFDKLFANNLTTPFRLSQAAMSTLAKSQNGS--IIYLTSCFGFTPSIDMGLYSVASSSVLSLTKSVAQS-AAKQGVRVNSVVSGMIEGDGTGAVWDHASGEEARPLGRLGRPSDVASYVEFLASTKARYITGEN---CIVGGGVS................................................................................................................................................................................................................ 250
6 -37.000[I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase  ali follow..  15  63........................................................................................................................................................................................................................................................................................................................................................TEQSPGEVVQKVESPVVVITGASRG-IGKAIALALGKAGCKVLVNYARSAKEAEEVAKQI----EEYGGQAITFGGDVSKATDVDAMMKTALDK--------------WGTIDVVVNNAGITRDTLLIRMKSQWDEVIALNLTGVFLCTQG----------------IINISSVVGLIGGQANYAAAKGGVISFSKTAARE-GASRNINVNVVCPGFIASDMTAELGEDMEKKITIPLGRYGKAEEVAGLVEFLASPAASYITGQ---AFTIDGGIAI............................................................................................................................................................................................................... 308
7 -36.600[Q] KOG1204 Predicted dehydrogenase  ali follow..  14  2.....................................................................................................................................................................................................................................................................................................................................................................GKVILITGASRG-IGLQLVKTVIEEDDECIVYGVARTEAGLQSLQR-----EYGADKFVYRVLDITDRSRMEALVEEIRQK--------------HGKLDGIVANAGMLESQSNSEHDKQWERLFDVNFFSIVSLVALCLPLLKSSPFVGNIVFVSSGASVKP-YNGWSAYGCSKAALNHFAMDIASEE-PSDKVRAVCIAPGVVDTQMQKDIRETLGPQGMTKTSSLLDPKVPAAVLAQLVKGIPDSLNGQ---YLRYNDER................................................................................................................................................................................................................. 257
8 -31.400[R] COG0300 Short-chain dehydrogenases of various substrate specificities  ali follow..  11  1...................................................................................................................................................................................................................................................................................................................................................................MRKKTIFITGASSG-LGRQLAIDFSWEETVLCLFARSQER-----LENVQRIVVENGGEAHIYPVDLADPQSIDRSFAEAISA--------------VGVVDVLINNAGYGVFEPFCDSQDENERMFRVNVFGLMRATAAVLPTMREQGSGH--IINIASQAGKIATAKSAIYSATKHAVLGFTNSLRMEL-KGTGIHVSAVNPGPIQ-TPFFDQADKEGAYTSKVQRIMLDPEDVSEKIVQLTKKPKREL............................................................................................................................................................................................................................... 228
9 -30.300[I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and related enzymes  ali follow..  10  3.................................GNLSFKDRVVVITGAGGGLGKVVVNDLGGTLGSGHNSKAADLVVDEIKKAGGIAVANYDSVNENGEKIIETAIKE-NNAGILRDVSFAKMTEREFASGGYKLSRAAWPYMRSQKFGRIINTASPALFGNFGQANYSAAKMGLVGLAETLAAKYNINVNSIAPLARSRMTENVLPPHILKQL---GPEKIVPLVLYLTHESTKVSNSIFELAAGFFGQLR-WERSSGQIFNPDPKTYTPEAILNKWKEITDYRDKPFNKTQHPYQLSDYNDLITKAKKLP--------------------------------PNEQGSVKIKSLCNKVVVVTGAGGG-LGKSHAIWFARYGAKVVVNDIKDP-------FSVVEEINKLYGEGTAIPDSHDVVTEAPLIIQ--------------TAISKFQRVDILVNNAGILRDKSFLKMKEEWFAVLKVHLFSTFSLSKAVWPIFTKQKSGF----IINTTSTSGIYGGQANYAAAKAAILGFSKTIALE-GAKRGIIVNVIAPHAETAM-------TKTIFSEKELSNHFDASQVSPLVVLLASEELQKYSGRRVILFEVGGGWGYVSIKETIEPEEIKENWNHITDFSRNTINPSSTEESSMATLQAVQKAHSSKELDDGLFKYTTKDCILYNLGLG--TSKELKYTYENDPDFQVEQYFKL--LAKPLQVLDKNGKA-YDIKTKKLIAYNEG-----SFFIRGAH----VPDFEAEISTNKDQAALYRLSGDFNPLHIDPTLAKA.......................... 816
10 -29.400[IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases  ali follow..  10  1.................................................................................................................................................................................................................................................................................................................................................................MDLAGKNVVYLGGFGG-IGQKCVQELLQRPIKALAIFDLNANEQLLAKWKS----QHPDTDVFYHKLDITQKSDIDAAYKAT--------------AERFGHFDVVVNGSGLMN-------DRLVELTIQINLLGVINSTLTALEYMDKAKGGKGGLIVISSVAGLQPTAIMAIYSAAKTGVTTFTRAMANPYYAHSGVGFLTICPGFTDTGLLEDIGNKTTFTYDTNRVKRQKAEDCARNLVSAIETSK----NGTVLMLEMGETTEGLAIFDLIVDDDLLAEWKKQHPDTEIFYQKMDITQKSDIDAAYKATAEKLGH-GSGLLDDRRIELTIQINLVGVINSTLTALEYMDKSKGGRGGIVNISSVAGLQPTPL--MAIYSTSKTGVTTFTRAMASPIH---YAHSGVGFTNTGILKDIDKKPFYETRMRTVFSKVKGQTAEVCARNI-------VNAIETAKNGA....... 451
11 -27.400[Q] KOG1210 Predicted 3-ketosphinganine reductase  ali follow..  14  24.............................................................................................................................................................................................................................................................................................................................................................SPKPLALPGAHVVVTGGSSG-IGKCIAIECYKQGAFITLV-ARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSDYNQVENVIKQAQEKL--------------GPVDMLVNCAGMAVSGKFEDLESTFERLMSINYLGSVYPSRAVITTMKERRVGR--IVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVK-PYNVYITVAYPPDTDTPGFAEENRTKPLETRSETTSVCKPEQVAKQIV......................................................................................................................................................................................................................................... 255
12 -26.900[M] COG3967 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)  ali follow..  17  1.................................................................................................................................................................................................................................................................................................................................................................MKMTNNTVLITGGSAG-IGLELAKRLLELGNEVIICGRS---------EARLAEAKQQLPNIHTKQCDVADRSQREALYEWALKE--------------YPNLNVLVNNAGIQKEIDFKKGTEELGDEIELNFQAPVHLSALFTPHLMKQPEAA--IVQVTSGLAFNPLAVYPVYCATKAALHSFSLTLRHHV-RDTSVEVIEMAPPMVDTGLNQKSRDK-----QGLTYRGISSEEYVQYFL......................................................................................................................................................................................................................................... 214
13 -26.900[Q] KOG1205 Predicted dehydrogenase  ali follow..  12  44..................................................................................................................................................................................................................................................................................................................................................................KVNGKVVIITGSSSG-IGEHLAYEYARRGAYLTLVARREDR-----LQVVADRCRKLGSDVAVVRGDVSVIKDCKRFVQET--------------ISRFGRLDHLVNNAGIAEAKFFEDYS-EISDVLPIVNTNFWGPVYATHFAIPHLKKTKGKIIAVASPAGWSGVPRMSIYAASKAAMINFYETLRIEL--HPEVGVTIVFPGLIENGNTNPDESLLQKQDWSQVVTIESAAECAKAVVNGICRGKTFVA.............................................................................................................................................................................................................................. 277
14 -26.600[S] COG3007 Uncharacterized paraquat-inducible protein B  ali follow..  9  29.........................................................................................................................................................................................................................................................................................................................................................DYVTTEGPIANGPKRVLVIGASTG-YGLAARITAAGCGADTLGVFFERPGEEGKPSAAFHKFAAQKGLYAKSINGDAFSDEIKQLTIDAIKQD--------------LGQVDQVIYSLASPRNSALKPIGNAIDSTVAVMGGEDWQMWIDALLDAGVLAEGAQTTAFTYLGEKITH--WNGSIGAAKKDLDQKVLAIRESLAAHGGGDARVSVLKAVVTQASSAMMPLYLSLLFKVMKEKGTHEGCIEQVYSLYKDSLC----GDSPHMDQEGRLRADYKELDPEVQNQVQQLWDQVTNDNIYQLTDFVG--------------------------SEFLNLFGFGIDG------VDYDADVNPDVKIPNLIQ............................................................................................................... 398
15 -26.500[Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11  ali follow..  15  49..................................................................................................................................................................................................................................................................................................................................................................SIAGEVAVVTGAGHG-LGRAISLELAKKGCHIAVVDIN-VSGAEDTVKQIQD---IYKVRAKAYKANVTNYDDLVELNSKVVEEM--------------GPVTVLVNNAGVMMHRNMFNPDADVQLMINVNLTSHFWTKLVFLPKMKELRKGF--IVTISSLAGVFPLPYSATYTTTKSGALAHMRTLRMELENQKDIHVTTVLPSFLRTNSDVTQLTHTIGFGDV--YPLFTGEEVAQRIV......................................................................................................................................................................................................................................... 270
16 -26.000[Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related dehydrogenases  ali follow..  12  1...............................................................................................................................................................................................................................................................................................................................................................MESGDESPVVLITGCSQGGIGHALAREFTEKGCRVVATSRSRSTMTD-----------EQDSRLFVKELDVQSDQNVSKVLSEVIDK--------------FGKIDVLVNNAGVQCVGPLAETPISA-IYWSFNSSGSMRMTQAVVPHMVSKKKGK--IVNVGSITVMAPGPWAGVYTATKAAIHALTDTLRLEL-RPFGIDVINVVPGGIRTNIANSAVATFNKMPESQRMNPTPAETFARDTVAAVLKK................................................................................................................................................................................................................................... 262
17 -25.900[R] KOG1611 Predicted short chain-type dehydrogenase  ali follow..  15  1...................................................................................................................................................................................................................................................................................................................................................................MSPKSVVVTGSNRG-LGFGLVQQFLKDPNVQHVIATARDVDKATALKGI------CDPRLHILQLSLGSDESIANFAEKVSEIVGES------------GLTLLINNAAVLPYVTKQKPDKVVLDLFESNTIGPMMLTQSLVPLIIKASKRSRGAIINIASEFLGSISENTAYRMTKCAVNQFTKTLSIDL-KDDHILTAGICPGMVQTDMSKGKGQ-------------LTIEESSSQILAAFNKLGATHNGG---YFRRDL................................................................................................................................................................................................................... 246
18 -23.200[I] KOG1478 3-keto sterol reductase  ali follow..  13  3......................................................................................................................................................................................................................................................................................................................................................................KVVLITGASSG-IGLALCKRLLAEDDELLCLACRNMSKAEAVCAALLASHPT--AEVTIVQVDVSNLQSVFRASKELKQRFQR--------------LDCIYLNAGIMPNPQLN-TADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFSGKEPYSSSKYATDLLSVALNRN-FNQQGLYSNVACPGTALTNLTYGILPPFIWTLLMPAILLLTPYNGTEALVWLFHQKPE................................................................................................................................................................................................................................. 277
19 -22.400[Q] KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali follow..  13  43..................................................................................................................................................................................................................................................................................................................................................................SAKGLVAVVTGSNCG-IGFETVRELNLRKADVYMLC-RSEEKANEAKRMLVRQGCDA-TRLHFIECDLTDFESVRRAAKETLESTDT--------------IDILINNAGIMFQSKHEQTKDGHEKTWQSNHLGPFLLTELFLPAVKKSS-YARIINVSSRIHLKSEFGMMKSYRQSKLANVMHARALTKELDGAEHVTVNSLHPGVVN-TELARNTILNTPGIKQITAVFRTSRDGAQTSIFLAGKKIGGISGK............................................................................................................................................................................................................................ 298
20 -21.700[I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3  ali follow..  15  48.....................................................................................................................................................................................................................................................................................................................................................................GQWAVITGAGDG-IGKAYSFELAKRGLNVVLI-SRTLEKLEAIATEIERTT---GRSVKIIQADFTKDDIYEHIKEKLAG-----------------EIGILVNNVGMLPNLLFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKG--LILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEE-YKAKEVIIQVLTPYAVSTA---------MTKYLNTNVITKTADEFVKESL......................................................................................................................................................................................................................................... 256
21 -21.000[QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases  ali follow..  16  26..................................................................................................................................................................................................................................................................................................................................................................HLQDKYVFITGCDSG-FGNLLARQLDARGLRVLAACLTE--------KGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDR------------GLWGLVNNAGILTPTLCEWLNEDSMNMLKVNLIGVIQVTLSMLPLVRRAR--GRIVNVSSILGRVA--FFVGGYCVSKYGVEAFSDILRREI-QHFGVKISIVEPGYFRTG........................................................................................................................................................................................................................................................................ 212
22 -15.300[M] COG1089 GDP-D-mannose dehydratase  ali follow..  10  2.....................................................................................................................................................................................................................................................................................................................................................................TKVALITGVT-GQDGSYLAEFLLDKGYEVHGIKRRASSFNTERIDHIYQDPHGSNPNFHLHYGDLTDSSNLTRILKEV-------------------QPDEVYNLAAMS---HVAVSFESPEYTADVDAIGTLRLLEAIRFLGLENKT----FYQASTSELYGLVQERSPYAVAKLYAYWITVNYRES-------GIYACNGILFNHESPRRGETFVTRKITRGLANIGHAKDYVRMQWLMLQQEQPEDTGVQYSVRQF---VEMAAAQLGIKMSFVGKGIEEKGIVDSVEGQDAPGVKPGDVIVAVDPRYFRPAEVDTLLGDPSKANLKLG-------------WRPEITLAEMISEMVA............................................................................................................... 348
23 -12.500[G] KOG0747 Putative NAD+-dependent epimerases  ali follow..  11  2.................................................................................................................................................................................................................................................................................................................................................................ASYTPKNILITGAA-GFIASHVANRLIRSDYKIVVLDKLDYCSNLKNLNPSKHS-----PNFKFVKGDIASADLVNHLLIT--------------------GIDTIMHFAAQTH---VDNSFGNSFEFTKNNIYGTHVLLEACKVTGQIRRF-----IHVSTDEVYGETDEDALYSATKAGAEMLVMAYGRSYGLPVITTRGNNVYG-AEAFEVVLHKGEVGHVYNIGTKKERRVNDVAKDICKLFNMDQRYFLDDQKLKTTWEEGLKKTGDVSGALLPHPRMLMMPGGRHFDGSEDNSLAATLSEKPSQTHMVVPSQRSNGTPQKPSLKFLIYGKTGWIGG-GIAYEYGKGRLEDRSSLLQDIQSVKPTHVFNSAGVTGRPNVDWCESHKTERANVAGTLT-DVCREHGLLMMNFATGCIFEYDDKFKEEDTPNFTGSFYSKTKAMVEELLKEYDNVCTL............... 536
24 -11.800[M] COG1088 dTDP-D-glucose 4,6-dehydratase  ali follow..  10  2......................................................................................................................................................................................................................................................................................................................................................................RKILITGGA-GFIGSALVRYIINETSDAVVVVDKLTAGNLMSLAPVAQS-----ERFAFEKVDICDRAELARVFTE--------------------QPDCVMHLAA---ESHVDRSIDGPAAFIETNIVGTYTLLEAARAYWNALTEDKKSAFRFHHISTDEVYGDSSPYSASKASSDHLVRAWLRTYGLPTLITNCSNNYGPYH-LNALAGKPLPVYGNGQQIRDWLYVEDHARALYCVATTGKVG-------TYNIGGHNERKNLDVVETICELLEELAPNKPQGVVHYRDLIT-----------FVADRPGHDLRYAIDASKIARELG-------------WLPQETFESGMRKTVQ--WYL--------ANESWR-----KQVQDGSYQGE-------RLGLK................................................................ 354
25 -11.300[M] KOG1371 UDP-glucose 4-epimerase/UDP-sulfoquinovose synthase  ali follow..  12  95......................................................................................................................................................................................................................................................................................................................................................................THVLVTGGA-GYIGSHAALRLLRDSYRVTIV-DNLSRGNLGAVKTL-QQLFPQTGRLQFIYADLGDPLAVEKIFSE--------------------AFDAVMHFAAVA---YVGESTLYPLKYYHNITSNTLGVLEAMARHKVKK------LIYSSTCATYGE---INPYGKAKKMAEDMILDFS-KNSDMAVMILRYFNVIGSDPGGRLG---------EAPRPELREQGRISGACFDAARGFIPGLQVKGTDYKTSDGTCIRDYIDVTDLVDAHVKALEGTGKGRSVKEFVEACKKATGVEIKVDFLPRRPGDYAEVYSDPTKILKDLN-------------WTARFT---NLQDSLQVAW-----RWQKIHPHGY............................................................................................. 433
26 -11.200[IE] KOG1430 C-3 sterol dehydrogenase/3-beta-hydroxysteroid dehydrogenase and related dehydrogenases  ali follow..  12  3..................................................................................................................................................................................................................................................................................................................................................................NKSGEVLLVTGGS-GFLGQHLIKQLLERKEELGIKEIRSLDIVPYKNN---IGHEETSLLRTYVADIGGDLKALSPIFNGV---------------------DGVFHCAASVKIEY----PPNYEELERVNVNGTLAVVDLCIQNNVK-----RLVYTSCTSVCFVPFKGRPGYASSKLRAENIVLNSNGAPLQKEYLATSAMRAPLTYGECDSHFITEIFDFLSTRGWVRIAGVGGKQQLVYAGNVAWGHICAYKALKVSVNGLPVFVTDDTGINDVSRFVQKMAVLGERFKVKTSWWYVPFFFLAFLLEVVVRVAYPYTKYRLRYSLRAIASYTSSMLMYNRLRASIHMDYMPLFDPDASAEAKWYA.......................................................................................................... 382
27 -11.100[C] KOG2865 NADH:ubiquinone oxidoreductase, NDUFA9/39kDa subunit  ali follow..  12  64.................................................................................................................................................................................................................................................................................................................................................................SSVSGIVATVFGAT-GFLGRYLVQQLAKMGSQVLVPFRGSEDSPR------HLKLMGDLGQVVPMKFDPRDEDSIKAVMAKA---------------------NVVINLIGREY-------ETRNFSFEDANHHIAEKLALVCEHGGIMR--------YIQVSCLGASVSSPSRMLRAKAAAEEAVL--------NALPEATIMRPATMIGTEFVKKYGFLPLIGGGTTKYPVYVVDVAAAIVAALKDDGSSMGK----TYELGG................................................................................................................................................................................................................... 282
28 -11.100[M] COG1087 UDP-glucose 4-epimerase  ali follow..  13  2.......................................................................................................................................................................................................................................................................................................................................................................TILVTGGA-GYIGSHTCVQLIEAGHEVVVVDN-----DNSHPEALHRIEKITGRAPRREPGDIRDRALMEQMIKR--------------------KCTAVIHFAGLK---AVGESSEKPLLYYDCNVLGTLRLLQAMEATGVKK------LVFSSSATVYGDLSATNPYGRTKLVIEDMLRDLYNSDNSWAIAILRYFNPVGAHESGLIGED----------------PKGIPNNLMPIIAQVATGRREKLNIWGN-DG-IHVNDLAAGHLKALKKLDKPKCFAVNLGTGQGYSVLDVIKAFEHVSNREIKYEIAPRRPGDVAECYA----------DPGFAKKFLGWSAEKNLREMCQDMW-----NWQSKNPNGY............................................................................................. 334
29 -10.500[MG] COG0451 Nucleoside-diphosphate-sugar epimerases  ali follow..  12  3........................................................................................................................................................................................................................................................................................................................................................................YLVTGTA-GFIGFYVAKRLLDAGHFVTGF-DGMTKYYDVSLKEKRHAILARSNGFRAEIGMLEDTDALKRAAE-------------------AAEPEIIIHLAAQA---GVRYSLENPRAYIDSNLIGSFNMLELARSLKVKH------LMLASTSSIYGANEK-TLYAATKKSMELMAHSYAH-----HKLPTTAFR-------------------------TVYGPWGRPDMAPIKF---VDAVSNGQPIDIYGQGNMSRDFTYIDDLVEGIVRLSAVIPSEENRVTQEGVTDTLSHHAPFRVVNI-ELMHFVETIEKAVGKPAIRNMLPMQQGDVPRTFASPDLRALTGYVPQTPVE---GIKALVA-----WYRGINGN...................................................................................... 336
30 -10.400[R] KOG4288 Predicted oxidoreductase  ali follow..  9  3........................................................................................................................................................................................................................................................................................................................................................................IVVLGGS-GFLGHNICKLAIAKGYEVVSVSRRGAGGL--------HNKEPWMDDVEWETLDAKDPNSLLPVLRDA---------------------SAVVNSVGILMENNYKKILQNPRGPVSHLINSLSSNMFKTGQETAKIAAKANVPVYCYVSAHAAAPGLDPRYIKTKREAEREISKIS-------NLRSIFLRPGFMYNFNDRPFTGALASLFTTASAEPLPSEEVALAALEAISDPS.................................................................................................................................................................................................................................. 254
31 -10.400[MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases  ali follow..  12  22........................................................................................................................................................................................................................................................................................................................................................TASEEPPMTLANLPPLVTVFGGS-GFVGRHVVRMLAKRGYRIRVAVRRPDLAGF--------QPLGNVGQISFAQANLRYRDSIIKAVEDA---------------------DHVVNCVGILA-------ESGRNTFDAVQEFGAKAIAEAARDTGAT---------LTHISAIGADANSQTGYGRTKGRAEAAIH--------SVLPGAVILRPSIIFGPEDDFFNKFAKMARNLPGKTKFQPEDVAEAVARSVDGKLKP-------IYELGGPDVMTFRDCLEAVLAATYRERSFVNLPFGVASMIGKLASLVPLITPPLTPDQVTMKKDNVVSAEAEKKGLTLEGIG....................................................................................................................................... 324
32 -10.200[V] KOG1502 Flavonol reductase/cinnamoyl-CoA reductase  ali follow..  11  1...............................................................................................................................................................................................................................................................................................................................................................MANSGEGKVVCVTGAS-GYIASWLVKFLLSRGYTVKASVRDPSDPKK----QHLVSLEGAKERLHLFKADLLEQGSFDSAIDGC---------------------HGVFHTAS--------DAKDPQAELIDPAVKGTLNVLNSCAKASS-----KRVVVTSSMAAVGYN-ASKMWYVLSK----TLAEDAAWKLAKEKGLDIVTINPAMVIGPLLQPTLNTSAAAILNLINGAKTFPNLSFGWVNVKDVANAHIQAFEVPSANGRYCLVERVVHHSEIVNILRELYPNLPLPERCVDENPYVPTYQVSKDKTRSLGIDYIPLKVSIKETVESLKEKGFAQF........................................................................................................................................ 326
33 -9.170[Q] KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes  ali follow..  9  249......VYYALRAGCERLIILPNLLVLTLQIMPDKEECFPACKLVAAGGEMVPANMYHTCKRVLPNAT--GTTESGLVSFLAYNGKDTLHNKELVYFPGKTVKKLMLAVPEKIGCTDVQSEPYVGDD-DLAVWNSYKGKLGITIKGRLGRRVKRNGVFFD--KYFDQVVVGLKEVKDAFSFFIFNRFVLVYVPAYNGVDPVTLKQKLNKELRDHHLFSSCFPLADIKSIETYASKCLSVEDQRLPVLLNPVAIEISKIASKILQNPSLEGKDAPLYSCGLDSIHSVRFFHAIQSHFHLEGPIRYNMNSNCTPNSIASIIQKKSYNVSSI---TYELLNEDACALSRTIPKLSILPTNGQYFLLTGAT-GYFGRRFLEYLVKLNISVVLVRESSDEAAKERLISLVPSLRISSENIIVWAAHVEDDAKWEFLVENV---------------------SRIYHMAA------EVHWMKSYQELRPANVLGTKTVLELSVMGPKALYFISGGGQQEVELDDDTQSAKASGYALSKYVAELLCRKISDLGHPLIYV----IRPGFIIANDGEILSRDFFWRFVATALRMGIWPQLCMTLTQILEKEAD................................................................................................................................................................................................................................. 881
34 -9.140[MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases  ali follow..  12  255...........................................................................................................................................................................................................................................................................................................................................QDLDIADLLGRAPVEPDLALLQKNITEKSVMVTGAG-GSIGSELCRQILAQKPKTLVLFELNEYNLYTIDQELQAIKQNLKLNTKIVAGSVQRENRVKKLMQA--------------------QVETVYHAAAYKH---VPLVEDNVIEGIRNNVFGTLACANAAIEAGVKN--------FTLISTDKAVRP-TNIMGASKRMAELVLQALADKNSTTIFTMV-----------------------------RFGNVLGSSGSVVPLFKKQIR------------AGG-------------------------------------------PVTVTHPDIIRYFMLIPEAAQLVI-----QAGAMSHNGQVFVLDMGEPVK---IVDLA-LMGMKEFCDGRSD------------EGDIEIKF-------TGLR-----------PGEKLYEELLIGENVEGTSHQK............................... 573
35 -9.030[CIQ] KOG1748 Acyl carrier protein/NADH-ubiquinone oxidoreductase, NDUFAB1/SDAP subunit  ali follow..  10  55...............TLEERIVLVLSLYDKIDAKKLTMDSDFKDL--GLDSLDHEVVMAMEEEFGFEIPDGDADKTPRDIFQYIADKEDVFE................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 133
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.