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Query: [C] COG5016 Pyruvate/oxaloacetate carboxyltransferase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTTQNKKIAITDVVLRDAHQSLFATRMRLDDMLPIAHELDQIGYWSLEAWGGATFDACIRFLGEDPWVRLRELKQAMPNTPLQMLLRGQNLLGYRHYADDVVDRFVERSVKNGMSVFRVFDAMNDPRNMKQALQAVKRNGGHAQGTLSYTTSPVHNLETWLEITEQLLEIGVDSVVIKDMSGILTPVEAYKLVSEIKKRYDVQLHLHCHATTGMAEMALLKAVEAGIDGIDTSISSMSGTYGHPSTEALVATLQGTQYDTGLDIHKLEHIAAYFREVRKKYAKFEGQLRGSDSRILVAQVPGGMLTNLESQLKQQNASDKLDEVLKEIPRVREDLGFIPLVTPTSQIVGTQAVINVLMGERYKTIAKETAGILKGEYGRTPAPVNAELQAKVLDGGQPITDRPADHIAPEMEKLATEIKQQAKEKGIKLAENEIDDVLIVALFPQIGWKFLENRGNPDAFEPAPTLETAKPAEKPAAPVAKTPVSGLast
1 -126.000[C] COG5016 Pyruvate/oxaloacetate carboxyltransferase  ali  100  1MTTQNKKIAITDVVLRDAHQSLFATRMRLDDMLPIAHELDQIGYWSLEAWGGATFDACIRFLGEDPWVRLRELKQAMPNTPLQMLLRGQNLLGYRHYADDVVDRFVERSVKNGMSVFRVFDAMNDPRNMKQALQAVKRNGGHAQGTLSYTTSPVHNLETWLEITEQLLEIGVDSVVIKDMSGILTPVEAYKLVSEIKKRYDVQLHLHCHATTGMAEMALLKAVEAGIDGIDTSISSMSGTYGHPSTEALVATLQGTQYDTGLDIHKLEHIAAYFREVRKKYAKFEGQLRGSDSRILVAQVPGGMLTNLESQLKQQNASDKLDEVLKEIPRVREDLGFIPLVTPTSQIVGTQAVINVLMGERYKTIAKETAGILKGEYGRTPAPVNAELQAKVLDGGQPITDRPADHIAPEMEKLATEIKQQAKEKGIKLAENEIDDVLIVALFPQIGWKFLENRGNPDAFEPAPTLETAKPAEKPAAPVAKTPVSG 486
2 -54.700[E] COG0119 Isopropylmalate/homocitrate/citramalate synthases  ali follow..  14  1..............MRDGEQTP-GVALTREKKLLIARALDEMRINVIEAGSAITSAGERESIKAVANAGLDAEICSYCRI------VKMDVDHALECDVDSIHLVAPVSDLHIKTKIKK-DRDTVRQIAAEVTEYAKDHGLIVE--LSGEDASRADPEFLKAIYSDGIDAGADRLCFCDTVGLLVPEKTTEIFRDLSSSLKAPISIHCHNDFGLATANTVAALAAGAKQSHVTINGLGERAGNASLEEVVMSLELYKYDTGIKHEQIYRTSRLVSRLTGIPVSPNKALVGGNAFTHEAGIHVHGLLADKSTYEPMSPEYIGRQRQIVL----------------GKHAGRSSITLALKEMGLEADEAQTEEIFVKQMGDQGKHITDADLQTIAETVLDIYKEPIVKLNRVTPTASIKLNVKDKEIVQAGIGNGPVDAVINAIRRAVSSCAEDVVLEEYHVDSITGGTDALVEVRVKLSKNGKVITA 457
3 -54.500[E] KOG2367 Alpha-isopropylmalate synthase/homocitrate synthase  ali follow..  13  54.KTIQKAPRWLSTDLRDGNQSL-PDPMSVAQKKEYFHKLINIGFKEIEVSFPSASQTDFDFTRYAVENAPDDVGIQCLVQSREHLIK-RTVEALTGAKRATIHTYLATSDMFREIVFNM-SREEAISKAVEATKLVRKLTKDDSYEFSPECFSDTPGEFAVEICEAVKKAWPIIFNLPATVEVASPNVYADQIEYFSTHIKVCISTHCHNDRGCGVAATELGMLAGADRVEGCLFGNGERTGNVDLVTVAMNMYTQGVSPNLDFSDLTSISEIVHRCNKIPIPPRAPYGGELVVSAFSGSHQDAIKKGFAIQNKKQAQGETRWRIPYLPLDPKDIGYEAVIRVNSQSGKGGAAWVIMRSLGLDVPRPDFSNTLQKNADALGRELKSEEITKLFKETYNYNNNEHIYVTPERRALVGQVEINDKVVNIEGYGNGPISSLVDALSNLLNVKL---SVQNYSEHSLGSGSATQAASFINLSYIKDINN. 564
4 -45.400[C] COG1038 Pyruvate carboxylase  ali follow..  36  554.MRNEKRVLVTDTTMRDGHQSLLATRVRTHDIARVASVYSKAQLLSLECWGGATFDVSMRFLTEDPWERLSLIREGAPNLLLQMLLRGANGVGYKNYPDNVVKYFVRQAARGGVDLFRVFDCLNWVENMRVSMDAIAEENKLCEATICYTARPKYDLKYYTNLAVELEKAGAHIIAVKDMAGLLKPAAAKVLFKALREATGLPIHFHTHDTSGISAATVLAAVDAGVDAVDAAMDAFSGNTSQPCLGSIVEALSGSERDTGLDTEWIRRISFYWEAVRNQYAAFESDLKGPASEVYLHEMPGGQFTNLKEQARSLGLESRWHEVAQAYADANRMFGDIVKVTPSSKVVGDMALMMVSQDLT............................................................................................................................. 921
5 -8.950[E] COG0710 3-dehydroquinate dehydratase  ali follow..  10  2.....NVLTIKGVSIGEGMPKI--MGKTEKQILNEAEAVKLLNPDIVEWRVDVFEKAN----REAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLESAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMS-NHDFEKTPVKDEIISRLRKMQDLGAHIPKM-----AVMPNDTGDLLTLLTIYADRPIITMSMAATGL--ISRLSGEVFGSACTFGAG-EEASAPGQIPVSELRSVLDILHKNT.................................................................................................................................................................................................................................. 253
6 -8.600[R] COG2108 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme  ali follow..  12  67.......................................................................................................................................................ANERPVRSEKDIIEEAKIQDARGAGI--TGGLARLSRTVEYIRLLKEEFGKKFHIHLYTTGILASEEALEKLDAGLDEIRFHPDLFQPNSKFEREIENMKKAFDFGWDVGGEVPAVPGFEDRIKWFASL.............................................................................................................................................................................................................. 197
7 -8.590[R] COG1646 Predicted phosphate-binding enzymes, TIM-barrel fold  ali follow..  14  1MFKMKVEDYFHDLTLIDPEEQ------TPEEAVEIARAAIRGGTDGIMLGGSTTDSSELD----------NTARALRENIDVPIILFPGNTTGVSRYADAIFFMSLLNSTN-GAQALGAATVKKMGIEALPMGYLVVEPGGTVGWVGDTKPVPRNKPDIAAAYAMAAEFLGMRLFYLEAGSGAPEHVPE-EMIALVKRCTDQILIV------GIRSGEDARVAGAGADVVVTGTVVENSDNVEDKIREIVEGMGSV...................................................................................................................................................................................................................................... 248
8 -8.510[G] COG3623 Putative L-xylulose-5-phosphate 3-epimerase  ali follow..  13  1...MARPIGIYEKATPK--------QFTWRERLQFAK---DLGFDFVEMSVDESDARLARL--EWTKEERLDLVKAIYETGIRIPT-GSNDPAIEAKSLKLMKQCIELAQDLGVRTIQLAKSPETRARFIKNLRQSCDWAEEAQVMLSIEIMDDPFINSIEKYLAVEKEIDSPYLFV-DAGNVSAWHN--DLWSEFYNGHKSIAALHLKDT------------YAVTETSKGQFRDVPFGQGCVDWQELFAVLKKTNYNGPFLIEAIKEAQDFLYPLIEK.............................................................................................................................................................................................................. 283
9 -7.970[G] KOG4518 Hydroxypyruvate isomerase  ali follow..  10  1............MALKFAANLNFLFTERATSIAERIRLAHQNGFRAVEIPYPEGETSDVVSAVKETGVVVSLVNLAFDKSDDQLRFGSTSVPGSEKLFRSQLDATIDFARQVNCGKIHLTAGLTYTANLKIAADSLRASKMIGVIPINKYAVPGYYMNSYSKAAGILADVAADNIQLLDLYHLQHLHG--NVSKTLEEYKALIGHFQIAQVPHRHEP---------------------DVSGELDYGFVFKALQEFGYDGWIGCE............................................................................................................................................................................................................................. 243
10 -7.430[GM] COG4464 Capsular polysaccharide biosynthesis protein  ali follow..  12  2...........................................................................................................................................................................................................IDIHCH---------ILPEIDDGPSSLEESLV-MAREAVKEGITKIIATPHHLHPSYNNKAAVVKEKVRKLNEAIQKENIPLEILPGQEVRISGDGLVSGDILTLADQGKYLFVEFSSNHVSRYADKLFFQLDIIPIIVHPERNHEFLKNPGLLYDLVNGGALTQITSSLTGHLGKKIKKFTEQIIEADLTHFLASDAHNVTERTFRIREAFALVEKNYGSSKAYEFQENAELLVE............................................... 234
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lukasz Jaroszewski, Zhanwen Li, S. Sri Krishna, Constantina Bakolitsa, John Wooley, Ashley M. Deacon, Ian A. Wilson, Adam Godzik, Exploration of Uncharted Regions of the Protein Universe. Plos Biology. 2009 Sep. 7(9):e1000205