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Query: [U] COG5096 Vesicle coat complex, various subunits, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSCWTLVQQDFLEAPSVDALKTSLESKNDYVKISAMKTILRVVINGDSLPSILMHVIRFVMPSRNKELKKLLYYYWEVCPKYNNDGTMKQEMILACNSFRNDLQHPNEFIRGATLRFLCKLKEPELLDPLIPTVRQCLEHRHAYVRKNAILAVFSIYQVSNHLIPDAASLAEDFLAAESEGTCKRNALIVLFTIDPEKAKAWLLANFEQIPSLNASSLLVIIEFIRKVVLTKADGLEKLRFQSLLVSLTATNNSSVVFEAATSVINVFPDAESLKLAASRLLALADREADNNAKLIMLDRISQLAARDKSILEDLITDVIPFLSSSDFDVCEKAISIIMGLVSSRNVEDILNHFQKELTKSNGETEKDDGRRRALTKAIHSCAINFPHTAATAIQYLLSHISDFQSKSASSVLSFIKEVMEKFPDLRSSNITKLLLSLKELRAGKIFRGVIWIAGEYCLTEDDIRVAWKSIRASLGEVPILASEEQLLKDVSNVPEDDLLIDISAPASTSRKVLPDGTYATESAVTSEALSAARLEAVKASKKPPLRTQILSGDYYLAAVLASALTKLVMRFARLSFDKERLNALKAEACLIMTSIIRVGQSKFVKYTIDDDSVERIMNCIRAIYSFEELPEFQTVFLDDMRKAFSSLVAQSDKRQKEADLLVNGSDAVQADELLNIRQFQRVIEEKQDLNFESDIIQATNDGMVVEDLASKLDHIVQLAGFTDPVYCEAYVKIQQFDIILDILLVNRTDTTLQNLSVDLATLGDLKVVERPPPMNLGPHAFKSVQATVKVSSTESAVIFGNIVYGGKASDEDKIVVLNGIPVNIIDYIKPAFIPESQFRSMWTEFEWENKVDISSNEDISLYDFLHKIMKKTNMNCLTPDASLRGDCGFLSANLYACSIFGEDALMSLSVEKSVSGPISGHVRIRSKTQGIALSLGAFVLast
1 -186.000[U] COG5096 Vesicle coat complex, various subunits  ali  100  1MSCWTLVQQDFLEAPSVDALKTSLESKNDYVKISAMKTILRVVINGDSLPSILMHVIRFVMPSRNKELKKLLYYYWEVCPKYNNDGTMKQEMILACNSFRNDLQHPNEFIRGATLRFLCKLKEPELLDPLIPTVRQCLEHRHAYVRKNAILAVFSIYQVSNHLIPDAASLAEDFLAAESEGTCKRNALIVLFTIDPEKAKAWLLANFEQIPSLNASSLLVIIEFIRKVVLTKADGLEKLRFQSLLVSLTATNNSSVVFEAATSVINVFPDAESLKLAASRLLALADREADNNAKLIMLDRISQLAARDKSILEDLITDVIPFLSSSDFDVCEKAISIIMGLVSSRNVEDILNHFQKELTKSNGETEKDDGRRRALTKAIHSCAINFPHTAATAIQYLLSHISDFQSKSASSVLSFIKEVMEKFPDLRSSNITKLLLSLKELRAGKIFRGVIWIAGEYCLTEDDIRVAWKSIRASLGEVPILASEEQLLKDVSNVPEDDLLIDISAPASTSRKVLPDGTYATESAVTSEALSAARLEAVKASKKPPLRTQILSGDYYLAAVLASALTKLVMRFARLSFDKERLNALKAEACLIMTSIIRVGQSKFVKYTIDDDSVERIMNCIRAIYSFEELPEFQTVFLDDMRKAFSSLVAQSDKRQKEADLLVNGSDAVQADELLNIRQFQRVIEEKQDLNFESDIIQATNDGMVVEDLASKLDHIVQLAGFTDPVYCEAYVKIQQFDIILDILLVNRTDTTLQNLSVDLATLGDLKVVERPPPMNLGPHAFKSVQATVKVSSTESAVIFGNIVYGGKASDEDKIVVLNGIPVNIIDYIKPAFIPESQFRSMWTEFEWENKVDISSNEDISLYDFLHKIMKKTNMNCLTPDASLRGDCGFLSANLYACSIFGEDALMSLSVEKSVSGPISGHVRIRSKTQGIALSLGAFV 940
2 -140.000[U] KOG1058 Vesicle coat complex COPI, beta subunit  ali follow..  38  7.PCYTLIVPSDAELPSEAQLKEKFEKGGDKERIEALKKLIYMILNGEKTSQSMLMVIRFCLPSNEHTLKKVLLIFWECVPKTDSNGKLLHEMILVCDAYRKDLQHPNEFVRGSTLRFLCKLREPELLEPLMPAIRACLEHRHSYVRRNAVCAIFTIYKNFEFLIPDAPELVTEYLEQEQDASCKRNAFMMLLHVDQARALDYLSGCIDQVGSFGDILQLVIVELIYKVCHNNPN--EASRFIRCVYNLLQSSSPAVRYEAAGTLVTLSNVPAAVKAAASAYIDLIVKESDNNVKLIVLDRLVALRGSNEKILQGLVMDILRVLSSPGLEVRKKTLSLALDLVSSRNVEDMVMFLKKEINKTATSNDENGKYRQELVKTLHAATIKFPDVASTIVPVLMEFLSDTNEKASSYVLQFVREAVHKLPNLKNAILGALREGIPFIQSPTIFMSALWILATYCEADGAL-DVLKLVKNSLGELPLVDSELSGQEEQKPEEQ-----QPEQQQKQKPKVTADGTYATQTALSSTVTTSK------KNEKPPLRRFLLDGEFFLGASLATVLTKLAQQFTELNGASERANRFRAECMLILSSIIHLAKSGLCIVHQQVNEDDLDRMGATIKILAQGIPGLDEQYGDDCKKSLELMLGTTEKMASTTAAGYRSKDFVEIDKTINFTQLSARSNQQGENLFDLSLSQALGTAPKAQKFSSKLGKVIQLAGFSDPIYAEAYVNVNQYDIVLDVLIVNQTSDTLQNVSLELATVGDLKLVDKPTPVTLAPNDFSNIKATVKVASTENGVIFSTISYDVTGSTSDNCVYLQDIKIDIMDYIVPGNVTDTEFRTMWSDFEWENKVNVMTPIR-DLRDFLNHLSTSTNMKVLTGDAAIEGDCGFLAANLCAHSIFGEDALANVSVEKDDSSPIVGHIRIRAKSQGMCLTLGDKL 953
3 -105.000[U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4, beta subunit  ali follow..  14  8.........TTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCM-QTDNLELKKLVYLYLMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDFLDSLRDLI-ADSNPMVVANAVAALSEISESHNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQS--ICERVTPRLSHANSAVVLSAVKVLMKFLEDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFF-VKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEV------DVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSEVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEKEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLVGQSFIPSSVPATF------------APSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPIHTPLMPNQSIDVSLPLNTLGPVMKM---LNNLQVAVKNNIDVFYFSCLIPLNVLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIW----ILAELRIQPGNP---NYTLSLKCRAPEVSQYIYQVY 931
4 -98.800[U] COG5240 Vesicle coat complex COPI, gamma subunit  ali follow..  10  1MSYSKKDDDGNVNQVTVTQDARAFNSSSPRKSRRLLSKIAYLIYTGEQATELFFGITK-LFQHKDPSLRQFVYIIIKELSVVAED-----VIMITSSIMKDTATGRETIYRPNAIRSLIRVIDANTVPAIERILTTGIVDPISAVASAALVSAYHLYPVAKDIVSRWNNEVQDAV-TSHNVGRKVASSPFFTSTLGGISQYHALGLLYRIRRSNSHAFVMLIRYISSLMDQNTQFRDQ--MVPFLHGWLKSKGDMVNLEVARNMVRLKNISDDDLQPVVSVLKIFLSSHRSATRFSAIRTLNELAMTRPHLVHSCNLNIESLITDVNRSIATYAITTLLKTGNDESVDRLMKQIVTFMS------DISDNFKIIVVDAIRSLCLKFPRKQDSMLTFLSNILCDEGGYEFKRAVDAISDMIKYIPESKERALAELCEFIEDCEYPKIAVRILSILGEEGPKASEPTRFIRYIYNRIMLENAIVRSAAVSALTKFGLNAEDKFVQRSVKVILTRCLEDA--------DDEVRDRAAFSVKALEDRDAFLPVVKSDKIPSLPALERSLVIYISE-----------------------------------------------------------------RKFGQGFDIKSVPVLSQEEIDAENLRIKKATTEVEFTEVTPAEDQNALASSNIETEFLNALESVSEFNEYGPVLKSSPSPIELTEQETEFVVKVVKHVFKDHLVVQFQLHNTLSEVLENAVVVSTPSTDDLVEECVVPAAIVSGEPVSIFVSFKFNDSVPTTLTNTLQFTTKEIDIHTEYKIDDLDVSAGDFISP--AYESNFDGLFDSLEHEASEVYVLSLLDSFRSTCSRVAELLQMQPLEGTENPTDKPV--VMKLSGKLVNGEKVLALVKMAHSKDGEITIKVIARGESDSSVELVVGGI 904
5 -95.100[U] KOG1077 Vesicle coat complex AP-2, alpha subunit  ali follow..  10  13.NCKSKEAEVKRINKELANIRSKFKGDDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVN-LLSSNKYSEKQIGYLFISVLVNTNSD-----LIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKLLGDTMDVVKQSAALCLLRLFRSSPDIIPEWTSRIIHLL-NDQHMGVVTAATSLIDALNPDEYKGCVNLAVSRLSRIAPWLSVKLLRLLQNYNPVTEEAGVRARLNETLETILNNAKNAVLFEAINLIIHSDSEPN-LLVRACNQLGQFLSNRETNLRYLALESMCHLATSEFSVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEMLNYLETA------DYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINREEVQGYAAKTVFEALQAACHENMVKVGGYILGEFGNLIAGDSRQFKLLHSKYHLCSPMTRALLLSTYIKFINLFPEIFRQHSNLRSADAELQQRASEYLQLSIVASTDVLATVL----------------------------------------------------------------EEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPAPLTSAAQNNALVNNSHSKLNNSNANTDLLGLSTPPSNNIGSGSNSNSTLIDVLGDMYGSNSNNNSSAVYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFNPVLQWSAEDALKLNVQEPTLEAGAQIQQLLTAECIEDYADAPTIEISFRYNGTQQKFSI---KLPLSVNKFFEPTEMNAESFFARWKNLSGEQQQKVFKAAQPLDLPGARNKLMGFGMQLLDQVDPNPDN--MVCAGIIHTQSQQVGCLMRLEPNKQAQ---MFRLTVRASKETVTREICDLL 928
6 -91.900[U] KOG1078 Vesicle coat complex COPI, gamma subunit  ali follow..  12  18.YSPFMGIEKGAVLQEARVFND--PQVDPRRCSQVITKLLYLLNQGEEATEVFFSVTK-LFQSKDTGLRRMVYLIIKELSPSSDE------VIIVTSSLMKDMNSKIDMYRANAIRVLCRIIDGTLLTQIERYLKQAIVDKNPVVSSAALVSGLHLLKTNPEIVKRWSNEVQEGI-QSRSALVQFHALALLHQIRQNDRLAVSKLVLTRGSVRSPLAQCLLIQRP---------------FYEFLESCLRHKAEMVILEAARAITELDGVTSRELTPAITVLQLFLSSPRPVLRFAAVRTLNKVAMTHPMAVTNCNIDMESLISDQNRSIATLAITTLLKTGNESSVERLMKQITNFMS------DIADEFKIVVVDAIRSLCVKFPLKYRSLMTFLSNILREEGGFEYKRIVDSIVTIIRDIPDAKESGLLHLCEFIEDCEFTYLSTQILHFLGIEGPNTSDPSKYIRYIYNRVHLENATVRAAAVSTLAK---------------------------------------------------------FGFMVESLKPRITVLLKRCI-------------------------------------YDSDDEVRDRATLYLSEPSEEAFDINSVPKEVKSQPLAEKKAQGKKPTGLGAPPAAPASGFDGYERLLSSIPEFAAFGKLFKSS------------------------LPVELTEAETEYAVNVVKHIFDSHVVFQYNCTNTIPEQLLE-RVLNIEAEEFSEVTSKALNSLPYDSPGQAFVVFEKPAGVPAVGKFSNTLTFVDDGVEDEYQLEDLEVVAGDYMVK--VGVSNFRNAWESMEDERVDEYGLGQRESLGEAVKAVMDLLGMQTCEGTETIPLNARSHTCLLSGVYIGNVKVLVRAQFGMDSSKDIAMKLTVRAEDVSVAEAIHEIV 828
7 -88.300[U] KOG1062 Vesicle coat complex AP-1, gamma subunit  ali follow..  11  19.ACKTAAEERAVVRKECADIRALINEDDPHDRHRNLAKLMFIHMLGYPTHFGQMECLK-LIASPGFPEKRIGYLGLMLLLDERQE-----VLMLVTNSLKQDLNHSNQYVVGLALCALGNICSAEMARDLAPEVERLIQFRDPNIRKKAALCSTRIIRKVPDLAENFVNAAASLL-KEKHHGVLITGVQLCYELNDEALEYFRTKCTEGLIKTDPFLHIRLLRLLRVLGQGDADASDL--MTDILAQVATKTESAVLYECVETIMAIEDTNSLRVLAI-NILGRFLSNRDNNIRYVALNMLMKAITFDDQAVQRHRVTILECVKDPDASIRKRALELVTLLVNENNVTQLTKELIDYLEIS------DEDFKEDLSAKICFIVEKFSPEKLWYIDQMLKVLCEAGKFVKDDVWHALIVVISNASELHGYTVRALYKSVLTSEQETLVRVAVWCIGEYGDLLVNNVGMLGIEDPITVTESDAVDTRHNSDSTTKAMALVALLKLSSRFPSISERIKDIIVKQKGSLLLEMQQRAIEYNSIVDRHKNIRSSLVDRMPVLDEATFNVRRAGSFPASVSTMAKPSVSLQNGVEKLPVAPLVDLLDLDSDDIMAAPSPSGTDFLQDLLGVDLGSSSAQYGATQAPKAGT-IGTPSPAQNSTSSIGLLSIADVNNNPSIALDTLSSPAPPHVATTSSTGMFDLLDGLSPSPSKEATNGPAYAPIVAYESSSLKIEFTFS-NLQTTNVQATFTNLSPNTFTDFIFQAAVPKFLQLHLDPSSNTLLASGSGAITQNLRVTNSQQGVMRMRIGYKLNGKDVLEEGQVSNFPRGL................................................................................................................... 876
8 -28.800[A] COG5181 U2 snRNP spliceosome subunit  ali follow..  10  368...EAKLTIAELRERKILRLLLKVKNGTPPMRKSALRQL---QARDFGAAALFNQILPLLMERTLEDQERHLLVKVIDRILYKLDDLVRPFTHKILVVIEPLLIDEDYYARAEGREIISNLAKASGLAHMIATMRPDIDHVDEYVRNTTARAFSVVASALG--VPALLPFLKAVCRSKKSWQARHTGVRIIQQIALPHLKNLVDCIGHGLEDEQQKVRIMTALSLSALAEAATPYEAFDSVLKPLWSGVQRHRGKSLAAFLKATGFIIPEPEYASHFTRRIMKILFNSPDEEMKKIVLKVVSQCASTDGVTPEYLRTDVLNNFKDESEPYRKMTAETVDKVIGSLGVSEIDERLEELLLDGLFAFQEQSVEEKVILTCFSTVVNALGTRCKQIVSTILYRLNNKSANVREQAADLVSSITIVLKALMRKLGVVLYEYLGE-EYPEVLGSILGAIKAIVSVVPPIRDLLPRLTPILRNRHEKVQENTIDLVGKIADRGSEYVSAREWMRICFELIDMLKAHKKSIRRAAVNTFGYISKAIGPQDATLLNNLKVQERQNRVCTTVAIAIVA................................................................................................................................................................................................................................................................................................................................................................................... 1004
9 -23.500[YU] KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily)  ali follow..  11  11..............EQVIQLLQHAHSTDRDVQRNVQVQLVQLNEH--KFCCYLVYILSDMKEMIDATSRSLAGLLLKNNIRAKWNKYPQDVKFFVRTTCLKSIGDQEPLIRATVGIIVTTIVMMCDWPDLLDTLATVLMQPDELMQEGALGALQKVFESADRYESEFLRPIMPKLYEHHAAKMRALAMNCVNCILMFAIDQFLTSLFARHNDNDEEVQKQLCRSLTLLLDTHIEKMMPHNVIEYIIKKTQDHNESIALEACEFWLSIAENSDICRTMVLPHLDKLIPGGDWNIRRCSAASLDVLASIGKDLLDKLFPLLKDTLMNDNWLVKESGILALGAIAEMDGVVPHLGELIPFMLAM---FDKKPLVRSITCWTLSRYSSHIASDFKDVLANLLRCSLDGNKKVQEAACSAFATLEEEAGEQLIPFLGEILDQLVKAYQAKNLLILYDAIGTLANSVGDVQMLMPPLMEKWER............................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 567
10 -23.000[C] COG1413 FOG: HEAT repeat  ali follow..  11  32SGNDSGTGTESMNNYFWVPSTVMQSIAAVYAVFIAIFALVSYTAVGSIYLNGLMLIIFSLHSPSELKIELMLFTSLLSLVASLIAIVYLSMEMLTSSEKFTYLTNLLRELEGWSSSGQMELSPGDM-----ELCVQGLEDEKPEVRIAAAQLLGWL--------EQAVDALLRKL-ADKNPRVREAAVEALGRVGDENI---VAELIGCLEDKNKGLRLQAVRALSRLGDERA--------VDPLVKKLEDKAPEVQAAAAEALGNL-KSQDSMDVLLKKLEESPMAGAPTEFQVQVLTALGKIGD------EKALAAILSRLDSPYPDIRKHAAEALGNLRDEKAVPHLVKKLA----------DISPEVRNASVYALGNLGDE------RAVSPLLRMLEEPDPELRITAVYALGNL-------APQAISPLINMLDD-DNPWVRKCTAEALGKIGD-----IKATDPLVKNLDDPDSNVRWAAAEA................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 491
11 -21.300[U] COG5215 Karyopherin (importin) beta  ali follow..  8  7................AQLLENSILSPDQNIRLTSETQL---KLSNDNFLQFAGLSSQVLIDENKLEGRILAALTLKNELVSKDSVKTPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIADIEL-PELMKIMVDNTGAEQP-VKRASLLALGYMCESADPQSQALVSSSNNILITETSKAVRLAALNALADSREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSLYYTFMKPYMLYALTIATMKSPNDKVASMTVEFWSTICEEENHILEPVLEFVEQNITADNWRNREAAVMAFGSIMD--TYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVSVDENQLTLEDAQSLQELQSSVEPVADMLMGLFFRLLEKKDSAFIEDDVFYAISALAASLGKLETFSPYLLKALNQVDSPVSITAV..................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 660
12 -20.700[YU] KOG1241 Karyopherin (importin) beta 1  ali follow..  12  343........................DDEDTWSPAKAASVCLMVLCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDNETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAETYALSPYFEYIITQLLDGAQANLRCAAYQALMDM-YLVVQRTTLVILERLNQVMQ-LQSLLCATLQSVLRKVHEQDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLPTIHRTVKPQVLSAFGDIALSIGLSMVLDMLRVASNLQTDANNFDMELRESILEAYTGIIQGLKGVDQ-HLMHIISFIGDVSDSMLASAAGFIGDLCTSFPLLDDAIITQFLAEGKRSKAQRTKMLCTWAVKEIKKINTQV............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 881
13 -19.800[U] KOG4224 Armadillo repeat protein VAC8 required for vacuole fusion, inheritance and cytosol-to-vacuole protein targeting  ali follow..  10  35..LEDRNEVNFYSEEPLRALTILAYSDNLDLQRSAALAFAEITEKDVRERETIEPVLFLLQSPDAEIQRAASVALGNLAVNAENKALVVKL---GLDLLIRQMMSPHVEVQCNAVGCITNLATLDAHSGALGPLTRLAKSKDIRVQRNATGALLNMTHSYENLVSAGTIPVLVSLLPSSDTDVQYYCTTSISNIAVDAVHRLVRSLIQLMDTSSPKVQCQAALALRNLASDERYQIEIVQ-LPSLLRLLRSSYLPLILASVACIRNISIHPLNESPIIDALVDLLSCTENEEIQCHAVSTLRNLAASSER--ANAIQKLRCLILDAPVSVQSEMTACLAVLALSDEFKSYLLNFGICNVLIPLTDSMSIEVQGNSAAALGNLSSNVDDYSRFIHGYLVRFLSSEDSTFAHIAAWTIVQLLEAGVPQSSDDIIELLNDIVA-RDANNGEYEDGEGDVILLSGRALHLIEQD...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 547
14 -18.500[R] KOG0567 HEAT repeat-containing protein  ali follow..  10  6..............................................................................................QIEAIGGVLNNKERKERFRALFTLKNIGGGAAIEAIS----KAFDDDSALLKHELAYCLGQM--------AQALDILTKVLKDTQEPMVRHEAAEAMGAIGHPDV---LPILEEYKQDPVVEVAETCAIALDRVRWLQS---------------GQKVDDSNPYASVDPSPPTAGD-----KSVTELKAIYLAQQSLFDRYRAMFSLRNLRT------EESVLAIAEGLKDSSALFRHEVAFVLGQLQEPCSIPFLQENLED--------RLENEMVRHECAEALGAIATE------DCIQILNRYAEDDKRVVKESCVIALDMC-------YENSPEFQYADGLA.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 296
15 -18.400[BD] COG5218 Chromosome condensation complex Condensin, subunit G  ali follow..  8  2...............SCIQIISSSQTSIAGHR-KLCNKLFTLR---EGFETDILRALNIILTVKK-NADRVLRFLVTFVNYLQQKDPEIDIVQPILKHILRGLDAKDKTVRYRCCQIIARV-DDDLYNTLKEKLLSRVLDRESIVRLEAVVALSRLQEDTGDEENDVRNILLFLLQNDPSSEVRRSVLLNI-----EVSNSTLPFILERARDVDAANRKCVYARVLPKIGD--RYLSIKKRVRILKWGLNDRDESVEKAAADMLLDVSNNSDVAVLAIKKFFDVICIEKNYTDLLDKMPEVVQLTYDESCFIIEQLLYIGLSQDMVDEIGRRKLLKSLTNSLSTMALPEIITEVFEQGHSQNQTRSHDLPIREKGLECLSLVCLLNADLAFENVPLYLHCYEKGSVVLKCTAIRTLTDMLFENAELQTLGAEAIAKLLLHYRDELFLKPLI-YFEPNTVDNHALRQVLGYFFPVYAFGAHENQWRIATIFCDALLSLLEIYRDLDEDDVQLSIGHIAQQMLDWTDNEKLYERKTQTGDDYIALNHFESLPNASEGKERKFMISLLGKLKI---PTDLPSSDYQRTKRKLETYESHGFTMDSTSLSILAKFERMLLQNEEARSKFEETEEERLMENAEENEHAGAEAISGEIIPDTVEANMEDEEEVYVKQEEDL.......................................................................................................................................................................................................................................................................... 875
16 -18.400[U] COG5064 Karyopherin (importin) alpha  ali follow..  11  1MESRYLSDRRSRFKSKADELRRQREEQQIEIRKQKREESL--------------------NKRRNLNAVLQNDIDVEEEADQSQVQMEQQMK--EFPKLTADVMSDDIELQLGAVTKFRKYLSKEIACGVVDRFVQFLESEHHLLQFEAAWALTNIASGTTDQTRIVVDSRFIQLLSSPEKDVREQVVWALGNIAGDSSAGVLQPLLNILQSSASDVSMLTLSNLCRGKNPPPNWSTISVAVPILAKLLYSEDVEIIVDACWAISYLSDGPNILDVGCAPRLVELLSSPSVNIQTPALRSVGNIVTGTDAQTQIIIDCFPSLLSHQKENIRKEACWTISNITAGNT-SNLIPPLVHLLSYA------DYKTKKEACWAISNATSGGLGQPD-VIKPLCDMLNGSDNKIIQVALDAIENILKVGEMEEAGGMDMIHDLQSS-GNNDIYLKAYSIIEKYFSDEDAVEDLA........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 510
17 -18.200[U] KOG0166 Karyopherin (importin) alpha  ali follow..  13  1MTTPGKENFRKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRN-MAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISVVARFVEFLKRKENCTLQFESAWVLTNIASGNIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGC-----------------------------------IKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRGLDKIEFLQSH-ENQEIYQKAFDLIEHYFGTEDEDSSIA........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 514
18 -18.200[S] KOG1949 Uncharacterized conserved protein  ali follow..  11  2...................LLECFININYIKKEEGRRFLSCLFNWNINFIKMIHGTIKNQLQGENDCIQDFMFHGIHLPRRSPVHSKVREVL-LYKPILWRGLKARNSEVRSNAALLFVEAEMDSKIQKQFEELYSLLEDPYPMVRSTGILGVCKITSKYPTILIDLLKKVTGELAFDSSADVRCSVFKCLPMISHPLLEQLLPALRYSLHDNSEKVRVAFVDMLLKIKAVRAAKFWKICPMEHILVRLETDSRPVSRRLVSLIFSFLPVNQPEEVWCERCVTLVQMNHAAARRFTACTNIAKLIHVIRHCLNACIQRAVREPPEDEEE-NVTVLDKTLSVNDVACMAGLLEIIVILWKSIDRSMENNKEAKLYTINKFASV--------------LPEYLKVFKDDRCKIPLFMLMSFMSAVPPFSCGVISTL-RSREEGAVDKSYCTLLDCLCSW----GQVGHILELVDNWLPT............................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 524
19 -17.200[O] KOG4413 26S proteasome regulatory complex, subunit PSMD5  ali follow..  11  35................LPVIFNALQTDPDIPGFTCLERLF---KYGASLIPQYMPVLQVGLKADSAVVKSLACKTVLCLLEDCDTNDVSSVQLVIYPLLLDYIINSDDEVANAASETIKSLRFPDAMSVIFPSLRNLAARCSSLARVRVLSLIVKLFSISRLVASGLLDLLEAEMKGTKDTLVILNVLELYYELMEVE-TSLIQLLCSIISGTSTGPYEKLRAMMISGRLLSKENIYKVSAIDGSLESVEMNDTDAQEAAIDALGQMGSTTKGADLVARHVVASAFDRNAHGKQLAALHALANIAGETRPSTKLTPSGLFLSVLQQSSEIRLAGYRTLTALVARPCLVEILAKIINIVTDATTETAKIMEARYNCCKAIHEAFLC----------------NFVDDPRRLKTGDKLQEAVRSGP.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 500
20 -17.200[S] COG5369 Uncharacterized conserved protein  ali follow..  9  288..............................................................................................YITQLFCLVRQFDPCIRLLSISCLVTLQTKEIQMIVTPILIRLFFESRE-AKQIAPRILAIIINENEIM---------------QKTAVNAGFIDAAKYLLEYATKEEENEINFLSDELQSSAACECLLSLSRSVYILRTGLADADVSEPLIKLLSDPDTRVKSTATSAICNLVLKFSPLREKFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLKLVELCNDEDLGVQEQMLQVLRNFTCQKEMELLAKILLEKLESK------NPILIEPSIYILVHIAASDGELRDSILRLVKEIMLQEAQRLKPEQMSTNVSSPESDSEMDRPPFDIYEEDTYE-PNSEILLAGIWLCKQCTSPSQEDKERASILQN................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 696
21 -17.200[R] KOG1293 Proteins containing armadillo/beta-catenin-like repeat  ali follow..  9  288..............................................................................................YITQLFCLVRQFDPCIRLLSISCLVTLQTKEIQMIVTPILIRLFFESRE-AKQIAPRILAIIINENEIM---------------QKTAVNAGFIDAAKYLLEYATKEEENEINFLSDELQSSAACECLLSLSRSVYILRTGLADADVSEPLIKLLSDPDTRVKSTATSAICNLVLKFSPLREKFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLKLVELCNDEDLGVQEQMLQVLRNFTCQKEMELLAKILLEKLESK------NPILIEPSIYILVHIAASDGELRDSILRLVKEIMLQEAQRLKPEQMSTNVSSPESDSEMDRPPFDIYEEDTYE-PNSEILLAGIWLCKQCTSPSQEDKERASILQN................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 696
22 -16.400[S] KOG0212 Uncharacterized conserved protein  ali follow..  12  1....................................................MDNLLVRGLTHKLYDKRKATAYELERVVKGYLENDETEKIRAVISQLANDFPARGPNATFGGLIGLAAVKIDSYMESILLPVLYCFNDSDSKIRYYACESMYNIGKVAKGEVFRYFNLIFDVLFADTEITVKNGAELLIKDIVMQQAATYMSSAEDIKNFKEGPVSSSIQDVVMSTEQPRMHTFSLSELVPLLSERLYVINPNTRMFLVSWIRLLDSIPDLLPFLLDGLMNYL-SDPNESIRIVTSNCLYDFLREIQKIYKRILEIIIDHLGSSVPLIQEKALKWLFEFIYIAPIPKVLENLLPLMSNDENMRQSAKDLSQNLVILVSKIMDIEFSDFRSLIEVLQKLLSNDNEETRLCALEWVLLLQRRTGNMHDPIFQTLLLQLSD-PSDLVVSRTLELLAHIAISHKSLVPFLKSLLQMFAE............................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 526
23 -16.000[TW] KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins  ali follow..  9  384...KSEARKRVNQLRGILKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNK-GVPRLLQVLKQTRDLETKKTDHTVNLRSRNGWPGAVAHACNPSTLGGQGGRITRSGVRDQPDQHGLLWNLSSNDMITEALLTLTENIGLLDFDIFYNVTGCLRNMMRRCDGLIDSLVHYVRGTIADYQDDKATENCVCILHNLSYQLEAELPEKYSQNIYIQNRNIQTDNNKSIGCFGSRSRKVKEQYQDVPMPEEKSNPKGVEWLWH---------------SIVIRMYLSLIAKSVRNYTQEASLGALQNLTAGSGPMPTSVAQTTRKMLHVGDPSVKKTAISLLRNLSRNLSLQNEIAKLVSIIPDTVPSTDLLIETTASACYTLNNIIQNSYQNARDLIQKIMAISAGDAYASNKASKAASVLLLWAHTELHHAYKKA........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 860
24 -15.200[BD] COG5098 Chromosome condensation complex Condensin, subunit D2  ali follow..  10  613LTAPDSCNMQEKAAHIAKNL--NLSIGASIADLASLEQLLGMMYEQKLIDQHVINILRDSEKGFSKEQIHGSIIILGMLSLADNEIALKGLESLL-NIGLGAVGLKDLTLCRYSCLALERMVEDVAVKKLYAIIINYTKDNEYYMCEQALSALFTISSKPDILATDLIREKTMMTFGKPEEE--DSILSLEQSSRVVSLSQLLFIVGQVAIKTLVYLEKCEAEFKKRKIEAETRNGKVKNVEEIVSNSSRFSDPMLQRTATLCLEKLM-SSKYCEKSLPLLITVMEKSPDPTIRSNAVLGLGDMAVCFNNLVDENTDYLYRRLHDENLMVQRTCLMTVTFLILAGQVK--LGEMAKCL------DNPDQGISDMCRLFFTELASK-DNAIYNGFIDIFSNLSSDDLLGKESFKKIIKFLLTDKERHQKQLNEKLVGRLRKCETQKQWDDIAFVLNNLPYKNEDVTALLEQGFKVVSA............................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 1174
25 -14.700[ODR] KOG4151 Myosin assembly protein/sexual cycle protein and related proteins  ali follow..  9  442................TPIMLEMAASQDHLMQGIAA-ELIVATVSKHERAINMIPVLRALYDSEDPTVKVRALVGLCKIKATMKEEAVISLAKTCKKFLKYSVDIRRYACEGLSYLSLDADVKEWIVDDLLKALVLLAKKAGALCVYTLATIYANLSNAFEKPKVDEEMVKLAQFAKDTEEYVEKRVRALVEE-------GAVPACVAVSKTESKNALELIARSLLAFAEYEDLRGRIIA-TVLCLRLTKEASGEGKIKAGHAIAKLGAKADRAYEVVKPLCDLLHPDVEGKANYDSLLTLTNLASVSDSIRGRILKE---WFMTDHEHLRAAAAELLLNLLFFEKFYEETDRLKLWVLYSAEV--EEERLSRASAAGFAILTERIMDEIKSWPEVFKDIAMHEDAETQRRGLMGIANIMHSSNKLCSEIVSSVFRVLVAVTKLGTINQ------ERAGSTEQAKRGLEAAEK................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 938
26 -14.600[J] COG5593 Nucleic-acid-binding protein possibly involved in ribosomal biogenesis  ali follow..  11  75...ERFSETLGHGTADKRMLQTLISSGTTSDRISALTLLV------QESPIHAVKALETLLSICSKKSRNLKDLFIGGLLPDRKESFLKSFYFKYIQIIEALSFDALLFVKSQMVSTIYDLAKPEQEQNLLKLLINKLGDKENKIASKASYSILQLEASHPAMKLVITKEIERFIFAPSSRTSCYYTLITLNQT--------------VLTHKQVDVANLLIEIYFVFFTKLLFALEKEEVADAPTLEKKSLQSDS-----------KNKKSQKRKKDEDLRKEAEENVNSRVISAVLTGVNRAYEVNSEKFDKHMNTLFAITHTASFNTSVQVLMLIFQASASRDFDRYYKSLYESLLDPR-TSSKQSLYLNLLYKSLI--IDNNIPRVRAFIKRMVQVSAWQQPPLVTGLFHVMHQLVIATTALRSMF.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 510
27 -14.400[OZ] COG5234 Beta-tubulin folding cofactor D  ali follow..  9  139LSQALNTPFPLNSLDDSLDVKKTIYTENSGIDKEASCLVLSRLFSRDDGLDLLLGFLHHCESSKRSIFYKIGCLSLSSFLKICPRNDCLQTVDVAFQFLEDLVGQENSALRKLLCKCYTRLGVHIYLEVIVDFLLSSVSDIDSFVRWSAAKGLAKIISRLPNLAEQVIDAIIELMTENMSPLVWHGAILFFAKLAGAGLISKCLHILPLIEVG-----------------------EVRYGTRVTGQSIRDASCYFVWSFYHCY-SKSAIEGLQTNLILCLLQTVLFDNEINVRRAATAALFEVIGRHASIPDG--LSLISHINYVSVTDISNCGDLCMKVAHFPQFSCVFQRLFTNLQH-------DVKVQQLSAFSLRQLSIKYPKELSIYLPPILDYLSVGNADFIFGYTIGLASIIGGFLSISFPFDINRIHDL...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 611
28 -14.200[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  7  30VASSTLLDDRRNAVRALKSLSKKYRLEVGIQAMEHLIHVLQTDRSDSEIIGYALDILYNIISNEEEEEVEEN----STRQSEDLGSQFTEIFIKNVTLLLSLLEEFDFHVRWPGVKLLTSLLGPQVQQIIVSRLMDLLADSREVIRNDGVLLLQALTRSNGAAFENAFERLLDIISEEDGGIVVEDCLILLQNLLKNNNSNYIQRMKPWFEVGDE-LMLQLVRVLVSPTNPPGATSSCQKAM-CTILMATGVPADILTETINTVSEVIRGCQVRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTLLPSTIDENATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGS-----KIQTRVGLLMLLCTWLSNCPIAVTHFLH-------------NSANVPFLTGQIAENLGEEEQLVQGLCALLESYMKEKLKQLIEKRIGNFIEKLGFISK--ELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGE------------------------------ETIIATKTTDVEGRLSALLQETKELKNEIKALS-EERTAIKEQLDSSNSTIAILQTEKD-KLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDES............................................................................ 952
29 -13.800[JK] KOG2038 CAATT-binding transcription factor/60S ribosomal subunit biogenesis protein  ali follow..  10  213YQHEINLFKSKTNSQKGASMKAIVSSGTLGDRMAAMILLIQ--------------------DDAVHTLQFVETL-VNLVKKKGSKQQCLMALDTFKELLITDLLPDNRKLRIFSQRPFDKLEQKHLVAEFVQVLETLSHDTLVTTKTRALTVAHELLCNKPEEEKALLVQVVNKL-GDPQNRIATKASHLLET----------------LLCKHPNMKGVVSGEVERLLSNISSKAQYYAICFLNQMALSHEESELANKLITVYFCFFRTCVKKKDVESKMLSALLT---------GVNRAYPYSQTGDDKVREQIDTLFKVLHIVNFNTSVQALMLLFQVMNSQQTDRYYTALYRKMLDPG-TCSKQAMFLNLVYKSLK--ADIVLRRVKAFVKGLLQVTCQQMPPFICGALYLVSEILKAKPGLRSQL.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 623
30 -13.700[YU] KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily)  ali follow..  7  392....KEEDFEEWTDSPQQWVLEQSTQDVEFNVRPCAEKLLKCFFDAYGFKDMIYSVFECPKTLTQAVQQDTLISSFGVGYTQLKSIFPFAKWLAVPNMASINDIGISRVYRRRIAIFLSQWIEEVIYKLYCSFLNLTDPCNDAVVILTTIDAFKTVLDD-ENLFVHVLSLFKAFESVDARTSIL-SLLGTLLARAGEHVAPMESTIASLLSQLEPLLRARVLAVMHQFVNAIKAKSFEFSVIEYCVNPESPEHVIFEADAMELWSTFLMYIQKFTLLIPHLLYHLSQATST-VSSYQLLDNTVLMKDYSFTIFEKLNDLLDDVKNETLQALCKTVCLLIETTPMDMISSLLSRLLLSIATNDKHPQVLIEYLLVVSRIS-KVCQTKNINIAMLIGNWILLNDHINHSKDRKLNTLLSSLLRTNHPDVLAVLDSIMNLWFSV................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 890
31 -13.700[O] KOG2062 26S proteasome regulatory complex, subunit RPN2/PSMD1  ali follow..  9  317YDREFLYAHNNTDMLILNRTKDSLEARNSVFHNAVT--ANAFMNFGTSSDSFFRDNLSWLSKANNWATAALGVIYLPEEDAPSSSTYSEGGAFYAMGLIHANKHTEDEIVQYGLLLGIGLTGMASRDETLYESVKTILFNDNAVAGSAAGISMGLIMLGTAS--SAAIDEMLQYAHETQHEKIIRGLGIGIALIRQQEADGIIKELNNDLDPTLRYAGMFATALAYC------GTSNSKIVRDVLHISVSDVNDDVRRAAVCALGFICFKDP---NALISTVELLVDSYNPHVRYGSAIALGIACANSGS--NAALDLLSRLVEDATDFVRQGAMIAQAMILTQHNLNSKVSGIRKHFEQVINEKHEDALAKLGATLAQGIIDA----------NVTIALQTATGSLKLSAIVGLTV-THFMSLSFSPTALIGLDKNLNAPKFSFISNVRPKLFAYPPKSVQPTAKTVQKVETAVLSTTVKAQARAKRAEREKASKGSNDDEMKIDKKTTEEKEATPMEMDEEKSQDISINGNS...................................................................................................................................................................................................................................................................................................................................................................................................................... 874
32 -13.700[O] COG5116 26S proteasome regulatory complex component  ali follow..  9  317YDREFLYAHNNTDMLILNRTKDSLEARNSVFHNAVT--ANAFMNFGTSSDSFFRDNLSWLSKANNWATAALGVIYLPEEDAPSSSTYSEGGAFYAMGLIHANKHTEDEIVQYGLLLGIGLTGMASRDETLYESVKTILFNDNAVAGSAAGISMGLIMLGTAS--SAAIDEMLQYAHETQHEKIIRGLGIGIALIRQQEADGIIKELNNDLDPTLRYAGMFATALAYC------GTSNSKIVRDVLHISVSDVNDDVRRAAVCALGFICFKDP---NALISTVELLVDSYNPHVRYGSAIALGIACANSGS--NAALDLLSRLVEDATDFVRQGAMIAQAMILTQHNLNSKVSGIRKHFEQVINEKHEDALAKLGATLAQGIIDA----------NVTIALQTATGSLKLSAIVGLTV-THFMSLSFSPTALIGLDKNLNAPKFSFISNVRPKLFAYPPKSVQPTAKTVQKVETAVLSTTVKAQARAKRAEREKASKGSNDDEMKIDKKTTEEKEATPMEMDEEKSQDISINGNS...................................................................................................................................................................................................................................................................................................................................................................................................................... 874
33 -13.700[T] KOG3723 PH domain protein Melted  ali follow..  11  1.......................................................................................MHFLLSRLLH--HRQLNVSAQ---------LFNVSHYDVITDMSNTFTCLILNAPSYPSNKVDQSVVEI----------VVARLTAAIRETGSIESYAAELVDVLDEVLRHPMTTLNEKCQDVDSPHCKIASDLLSSLFLASRKTGTIISNVV-----------RGNYSLIRVLPHIYPD--NKEPFHAQLSQLIDLL-TEVDCSEKLSLLQLSSMVANTKPDVLIPFLPRFDVYLLSPQMS--TALLNIYMSLISQNRTKSLSQFLPTLKLAAQSNEFINN--RTTICKIIANIGRVSSPLASEAVDELVLMNNSSDQQILQTVLNEIDAIGSIHPTSLRRHVSFFQTLPTSRIIERILAHL.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 330
34 -13.500[T] KOG4500 Rho/Rac GTPase guanine nucleotide exchange factor smgGDS/Vimar  ali follow..  11  5.....................................................IDDLIEKLKTTSVSPANTTNLLCEISATKDPKLFDKHELA---ECFLGLTKCDDTNVRKEAAKCIAEFTKRNIIAAFLECLRQPTSDGSMELPIQICRALGNICYLNDELELEGDAVLLRLLDIANAAQFIKVRGGLLSNYLLGG-LGVMKKLQGIIDIGAS-LLLNTLPLLSILTENVSDLNFDSSLNIQLSRILAASTNPDLAEMCLELLHYQAESDEVKLLCETIYNLLEKSEARALMKLACELIVLILTGDDSM-TPLLKNMVDWLDSTDIDLLTTGVLALGNFATDSHCIYFVEQLLEVLAKNNGV-KDDVRLQHALLSALRNLVIKNAVIQAGLVQTILPMLEIHQPPVVFKLLGTLRMTVDGQEKLALELIEQLVHWSKSSDYAGVTGESLRLMAWLIKHAYLSKIAYALPRKGDAPAEQIADKIPLTQDYDRSSLSEFLANEGTVEAMVSMLTAQHLVMQNEAL............................................................................................................................................................................................................................................................................................................................................................................................................................... 541
35 -13.100[YU] KOG1992 Nuclear export receptor CSE1/CAS (importin beta superfamily)  ali follow..  11  355....RAADEEAFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCFEGPVTGIFSGYVNSMLQEKDAAIYLVTSLASKAQTQKHGITQANELV-FFVNHILPDLKSANPVLKADGIKYIMIFRNKEHLLVSIPLLINHLQAGSIVVHTYAAHALERLFTMRGPFVEILLTNLFKALPGSSENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQKPHFNHYMFEAICLSIRITCKANPAAVVLFLVFTEILQNDVQEFIPYVFQVMSLLNDIPSSYMALFPHLLQPVLWERTGNIP--LVRLLQAFLERGSNTIASAAADKIPGLSKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQNSKTTKFIKSFLVFINLYCIKYGALALQEIFDGI-EIQKVSGNVEKKICAVGITNLLTECPPMMDTEYTKLWTPL...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 868
36 -13.100[D] COG5657 CAS/CSE protein involved in chromosome segregation  ali follow..  11  1................MDDIPTLLARTNPTTSKSAEEALKVWELQDSSFALKLLNIV--AEDTVDINIKLAASLYFKNYIKKASIRISDEVAELIKREIINLMLKSTTIIQGEVIGYIANFDFPDRWDTLLPDLISKLSAVDMNTNIAVLSTAHAIFKRWDRFCEPFLALFVQTNNLLRNGPQDAESLNSLFQVILLECKLFYDLNCQDIPEFFEDHMSEFMTAFLNYFTYTNPSLEGDEGETNVLIKVKASICEIVELYTLRYEEVFTMLYDFVNVTWTLLTTLTPDEKQQFIELVVLPNICLRESDEELFEDDPLEYVRRDLE-SDSRARSAIVLVRGLLDQKITSVVSTHINANLQQFSTNPSLEWNKKYVALQLFSAIAIKGSQQLIDIFPTILRFLEMPSFVVYTYAAIALDQLLTVRHNHVLPALNQLFLIVESASTPQLMKAVMRIIIMSQEAILPLQHLTKITEEVSKNPSNPKFNHYLFESIGALIRSLSKSGPQTVSQLENALL.......................................................................................................................................................................................................................................................................................................................................................................................................................................... 639
37 -12.800[U] KOG2081 Nuclear transport regulator  ali follow..  11  9....................................................VYQAISALFQGNNPKEQEKANKWLQDFQKS------IYSWTIADELLHQKRDLHANYFAAQTMRNLPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADLALLMASWREPINDLLVTLAPHQCAIWPLLEVLKVLPEEIDSRYLRLGANRREEVHKQLDASAECVLKFLCMCLQREDLDQQRVWNAALAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCALLVAHEDTDKTINYCRIFTSLCDAKPHYSLKGLDLVLLCVGHFDYEVAEITFHLWYKLSERPHIERLISALFRHSQMESDHDGLIEEFRRKVSDLIKDVAFIVGSGA--CFKQMFHILQAPETT-TEAALFIMQNVAKNILPDENEVIPKVVEAILNMTHIAVRYTAILLIGELCDWIENHPESLEAVLNFLLYALQQKNGLAPAAAIA................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 528
38 -12.700[O] COG5656 Importin, protein involved in nuclear import  ali follow..  9  3...............QEQAILSCIEVADAKIIKEAEQQLFEF----QKQPGFTSFLLNIVSDDNALNVRLSSAIYLKNKIHRSWDTKREDGI----LSIKERLNCENNHIRPILTETINGILVGQEDWDLAPIIKNLLSSGDASYIYPGLLLLFQLCKAHDSVIEELFPIVEGIASNSQTDYRSNEILYLILKSFKYACLNNLPQYFSQPERIMSWVQL-HLYLCSKPLPVEVMELDPADRSLDKRVKVNKWGFGNLNRFLQRY------NKITKAITKEFIDYIFNTIVPIILREFFKDIEAWGNNSLWLSDSSLYFLISFLEK---LIEPHLQIIFENVINEQSIELLEDDQEEYTRRYFDINREGSTPDAASADFIFLIGSKRPEKLNNILPFINDIFTRFDANSSDITLSNLFSFIDEPSVLENIFGHFIVPLLSQDKYMFLVARSLETIALYSEEFNILSQLFELTYTNFLNSNVLPVQIEAADAIKCLIVSNPQIHPAVSAHVPGMMEKLLKLSKIFEIDILSEVMEALVERFSDELSPFAKDLASN-------LVEQFLRIAQALVE.............................................................................................................................................................................................................................................................................................................................................................................. 593
39 -12.200[A] KOG1104 Nuclear cap-binding complex, subunit NCBP1/CBP80  ali follow..  10  21...RRRVSENQEIEDRLESLILRVGERSTSSVESNLEGLVSVLE--ADLGTFRLKILRILSDAVRMPEKCTVYTTLVGLLNAKNYKFGGEFVDHMVKTFKESLKMCRWDAARYSLRFLADLVNCHVISQLLDTMIDVSNEDTVPQVRRVFAVLSTLPWVGRDLYEKKESALESLLLRNKRSKKHHNALRVWSSDAPHPQEEYLDCLWAQIRKLRQ-IEEHLHHIIETY---HHERKDCAAQLLSFPYKHKIPLEYCIVEVVFAELFHMPTPRYLDICYGSILIELCKLQPATLPQVLAQATEILFMRIDSMNTSCFDRFVNWFSHPRPKFIQEVLQKCLRLSYHQRITEMMHQLVVAIRQKCTPEEVVNILKDIFVQTLLNLGSKSFSHSFAAISKFHSVFRAETEEAQICILHNIFELWSSHQQMMVVLIDKLLKL-------DCSAVATWIFSKEMTGEFTKLYLWEILHLTIKKMNKHVIKLNTELSEAKEKLAKADSSSSDSEDDSSHKRKKPITHADKPSEEVVERMEEKLEAANVNQKRLFLIVFQR................................................................................................................................................................................................................................................................................................................................................................................................... 726
40 -11.800[R] KOG1243 Protein kinase  ali follow..  10  51....................IRSGSDTKCELAKAALKRLKTLR---------HPSILQYL---DSLETDKMLYVATEYFSKLGSDNVQKGLYLITGNLRHNNVSAWSVFVNASGEWKLGSLEYVSAADGNPMPPAKIPVTLEVYDSPEKNCLVWEAFKDIEHIPKSLQSLYCELVGASPSNRPNPADIITRCRKPGGFFKNDLVDTLLFLEEIDKAEKNRFFSGLTTHLDNFPDNVCRHKILPQLITAYEYGDAGSAVLAPMFKLGKLLDEVEYQKRIVPCVVKLFASTDRVTRSRLLQQLDLFIAHLQPVNDQIFPQVAHGFLDTNATIREQTVKSIIHLAPKLNYNNLNVEVLRHFARL--ARDDQGGIRTNTTVCLGKIAPHLHPQVRVLVSAFIRAMRDPFPPARVAGVLALAATQQYFSEVANRVLPSLCSLTVD-PEKTVRDPAFKTIRGFLGKLEKVSE.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 542
41 -11.800[YU] KOG2022 Nuclear transport receptor LGL2 (importin beta superfamily)  ali follow..  7  384..................TLIEDFSMSKAATDKQIAFSVVEKAWW-RDLGDLLESSYSIFGER---LYAMYITTIENFFSDGTGSPQSLEVSFYCLCCILEYDTNDNPQLLKTCSQLLSSCNHPQYLNISLPVLFDALHISETSIQMTVSRSIHTLCTTCASHLLTEIDGFMAVYVPSVLEKIYSSVGYVTQRIDIELRISYLMRLLNCILEIFENVLKSCLQSVAGVALSQSPIGESPIIDVEQSTQETTFWQQ-LISFLTHSESMALQYSDVVGLICKIMIAGLNEVEPSPFSLPIVTTIQYFCD------------RFTEFPAAVLLTLGSAILTCPYGQTDIIDKVLIDMCSSIQNSEESFMNNIDITVELYHFFSIILQKHPSFTQLILNRAINLLGKPERLLESAAGQFIISFITSEKSDLLNTHTDFVNAIRSPLIAKILLGFGGNASR--SSLPLLSDILGKLKAQNFSATRACLTQSLEE................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 939
42 -11.500[T] KOG2137 Protein kinase  ali follow..  8  73VCVWMLDKRALSEARVRANLSKAAEDAFLDLIRADAGKLVRLR---------HPGVVHVVQALDE---KNAMALVTEPLFKDLKSMEMSLLEVISANLIHRAISPENVLITSAGSWKLAGFGVEDSILPVQPSLNELMRSKSPSAGASS-CLAYHLVESFSSIPSELVSDLQRMLSTNESFRPTALDFTGSNFFRSDARLRAL-RFLDHLLERDNMQKSEFLKALSDMWKDFDSRVLRYKVLPPLCAELRNLVLQPIILPMVLTIAQSQDRTDFELITLPALVPVLSTASGDTLLLLVKHADLITNKSEHLVSHVLPLLLRAYNDNDVRIQEEVLKRSTSVAKQLDGQVVRQAILPRVHGL--LKTTVAAVRVNALLCLAELVQTLDKPAEILETIQRCTAVDRSAPTLMCTLAVANAILKQYGFTAEHVLTLMMPLTAQQLNVQQFAKYMLFVKDILRKIEEKRGVTVNDSGVPEVKPHSAANGLQFQSSTQIPEKVASAAKSSPAWDEDWGSPSKDSAVGNPASSRHNTNDQFNKSTDQSQPSIMSTLPNKTTAPTTCPAVDIEWPPRQSSSLTAPATDNQTQLNTGTSFASGFDELDPFANWPPRPNNGASVASTGLKNGAASNFSNNLPGGTHFQTANNDNWAFSSASLSSLKPPQQGNQGISANNQDPLNSFGVPKQSQGMPSFTSGSYNNQKPADISSIFGSSKTE.................................................................................................................................................................................................................................... 866
43 -11.300[S] KOG2149 Uncharacterized conserved protein  ali follow..  11  3....................RSKAPARKQQKKGIDFKKI---RKLGRKLP----------ATNTEIKSKAIIL---EQSVAAERDGFATSKKGLTLLELKNRTGHPNAKVRKDALHGIKDLLKHH-KYATTHKLRELITDDDKLVRDDFYTLLTGIFLACKINKGLMVSSLMPYIMTKSSIEVRLMAFKFF-PTFSLYAEKILENYKDVIHNNHFYIQDKKKLKVVLLGLADCLSLLPCDQSDNESKKKGLLQYETLLACEQDAAKECVRFAHVSGILKEIVAVLINKESFDCIRHILRSIGYAIKFDRDIASMLSKKLLGSFNNFSVENNGVLTEIFLEVSEWSHSNRFLEFIENALLGKITRSNSLDKTLLALLPFVPKLLLRVDRDRDNLMQAFTITFNNCKSSLKLACISVVKDLIIPNGDILYPNDPTVNNYQRA-----------WVLNQLGDKHHVSTKVVLQLLLDLARVGCLNASPTFEEEI................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 529
44 -10.800[JU] KOG2153 Protein involved in the nuclear export of pre-ribosomes  ali follow..  9  228....KRRELMQEFKDTIASHANMLLS-NPQVNIVRLRDLYNLCNGEKIHSLVRESVQKLAIASTLQVLLDILPGYAIREQTAEEKAQKQKKETRNLVNYEESLLR-LKYLQLCSVKALARIVVSNYSTNIVSSLVRLSLAKNETVIREVCEAIRTVFK------------------EDIHLKITLFTARSISTLVTKRKGRVPPELLRTLLSMNITEVKDEDKKSGKDALIAKKYQIKKEKASKTAKKYKKQLARLEADLLEVEAEESMSTEAMKFAFQSYFSILKRMPNSALLEPVLEGLSKFAHLLSIEFYEDIVSTMENMVQDQLHCINTVFVILSGDGQLLNIDKFYRLAYRVLNHLPFEKRPEQRKNQMAAKTLETMLVIRRKAVPAFVKRLLSIATVLDDFPALCIVSLVRSLFIAHPKLSSMI-GIYRPDIDDPDVANALASDVR---ELSMLARRRNTELSRFANNILY............................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 739
45 -10.700[O] COG5021 Ubiquitin-protein ligase  ali follow..  8  236IKKVTMTTQELCEHSLQQIFDKGMALLPAESWFDFSIKASVAKAFSDDSG-------ENIDLRNIIIETKLNAIAFVNTIFSPPQVSSPYAFNSLTDLISLSETKIPKELRTDALFTLECISLKHVCSDIIRNLGGNISH--QILRYIAKTLREATDEIDEEYNVRFFYLISNLADVKPLHESLFAALLEIVSIRNCPYKRTLASATHLLETF-----IDNSETTTEFIENDGFTMLITSVANEIDFTLAHPETWQPPKYSVVYYSISFRELAYIRSLLKLVLKLLSTDSGD-------RIRNLIDSP---ILVSLKKILENKLVFGLTLITYTLDVVQKVISEPTIYPVLVEIPYVIDNFPKLIGPSAELLSLLPDVVSAICLNPE-KEKGLINNLFDFLLDAGGDRSTEYGTDIDELARHYPDLKANIVEALCNVIRKMPS................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 685
46 -10.700[J] KOG2154 Predicted nucleolar protein involved in ribosome biogenesis  ali follow..  7  3...........LLISEIKDIAKRLTAAGDRKQYNSIIKLINELVI--------PENVTQLEEDETEKNLRFLVMSLFQIFRK----------LFSRGDLTLPSSKKSTLEKEQFVNWC-----RKVYEAFKTKLLAIISDIETSLGLDSLDVYLQLAELESTASEKGAPFFPNKTFRKLIIALWSSNMGEIEDVSGASENLIIVEFTEKYYTKFADIQYYFQSEFNQLLEDPAYQDLLLKNVGKWLALVNSVDADLEIFVPNPPQAIENESKFKSNFEKNWLSLLNGQLSLQQYKSILLILHKRI-HTPTKLMDFLTDSYNLQSSNKNVVPILALNGLFELMKRFNLENFYMKLYQIINPDLMHVKYRARFFRLMDVFLSSTHLSAHLVAS-FIKKLARLTLESPPSAIVTVIPFIYNLIRKHPNCMIML-DPFDVHESDPELTHALDSSLW---ELASLMEHYHPNVATLAKIFAQ............................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 486
47 -10.600[D] COG5537 Cohesin  ali follow..  10  95.............DMPLEQLSQHYFEDYKSNSADFMLTFINFALVGCQPF-----VTNFDVQDVDSIPETLSQVNRSSFQKSSCAYTDYLYT----KTVRIRFQL-VEFISKVYVEDA--FLGDSFMETTKAWIFTMTTSPWMLVRHTATTICCDIMRCLCLILSEKSNQTAEILVLRDLTSRFIDMIHDICD------------LFSRIHDIRASIRIVCVTALYDCCQLLPTYLINRNLIRHSGWGLSDAESQIRKISLKIIDYLSSHEPEVVDFLDRFSLRIVEYDIDSVRSVALKTCEKLMEKI--LNGKCINIVSSCIFDGKPQNRISTMRILVAHTNER-----YANYCEAKTATISLSKLLRREKIPLLVSSFESLFKMNALLFILEQGFESWFRDSSDHIFSRV................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 486
48 -10.500[G] KOG2175 Protein predicted to be involved in carbohydrate metabolism  ali follow..  9  138...............ELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTELHHLYEIIRGILF---NKATLFEVMF-VVGCLEYDPALAQPLTKTAKFKEVIPITDSELRQKIHQTYR-------QYIQ---------------DIILPTPSVFEENFLSTLTSFIFFNKVEIVSMLQEDE--KFLSEVFAQLTDEAT---------------DDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTL---------AKLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVREFVMQQMICDTDPELGGAVQLMGLLRTLIDPENMNHCMHVLTAPLLTNTSEDKCEKDFFLLILELLTFCVEHHTYHIKNYIRRVLVLMNSKHTFLALCALRFMRRIIGLKDETKGNLFEPVINALDNGTRYNLLNSAVIELFEF--RVEDIKSLTAHIVENFYKALESIEYVQTFKGLKTKYEQEKDRQNQKLNSVPSILRSNRFRRDAKALEEDEEMWFNEDEEEEGKAVVAPVEKPKPEDDFPDNYE--------KFMETKKAKESEDKENLPKRTSPGGFKFTFSHSASAANGTNSKSVVAQIPPATSNGSSSKTTNLPTSVTATKGSLVGLVDYPDDEEEDEEEESSPRKRPRLGS........................................................................................................................................................................................................................................................................... 849
49 -10.100[YU] COG5101 Importin beta-related nuclear transport receptor  ali follow..  9  445............ENDEGEIVREFVKESDTIQLYKSEREVLVYLLNVIDTEEIMISKLARQIDGSEWSWHNINTLSWAIMSEDTEKRFVVTVIKDLLDLTVKKRKDNKAVVASDIMYVVGQYAHWNFLRTVILKLFEFMHETHEGVQDMACDTFIKIVQKCKYHFVIQQPRESEPFIQT----IIRDIQKTTADLQPQQVHTFYKACGIIISEERS--RNRLLSDLMQLPPTLLLDSETVKIIANIIKTNVAVCTSMLYRAVSSMISAQVAAEGLIATKTPKVRGLRTIKKEILKLVYISKARNLDDVVKVLVEPLLNAVLEDYMNNVPDARDAELNCMTTVVEGHMIPQGVILILQSVFECNKDFTEYPEHRVEFYKLLKVINEK-PAAFKLFVDAICWAFKHNNRDVEVNGLQIALDLVKNHKNYFFIFVSETFFVLTDSDHKSGFSKQALLL...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 959
50 -10.000[T] KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  12  101......LREKEIKRQTLLELVDYIATVSTKLSDAAMQEIAKVAVV---------NLFRTFPSANHESKILETLDVDDEEPALEPAWPHLQVVYELLLRFVASPMTDAKLAKRY------------IDHSFVLKLLDLFDSEDQREREYLKTILHRIYGKFMVHRPFIRKAINNIFYRFIFETEKHNGIAEL---------------------------LEILGSIINGFALPLKEEHKLFLIRALIPLHRPKCASAYHQQLYCIVQFVEKDFKLADTVIRGLLKYWPVTNSSKEVMFLGELEEVLEA-QRCMVPLFRQIARCLNSSHFQVAERALFLW----NNDHIRNLITQNHKVI-------------MPIVFPAMERNTRGH------------------NQAVQSLTLNVRKVMAETDQILFDECLAKFQEDEANETEVVAKREATWLLEELAAS................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 479
51 -9.990[S] KOG2734 Uncharacterized conserved protein  ali follow..  9  76........DPELTEEERLNILKYVENEEADGDEQSLKKLILVFLKNQEMRIKFADSPEKFMDSEVELHTVIQEL---KGVATVPDLYPILVDLHGLHSLLELLAHQNTDIAVAVVDLLQEVTDVDICALLVQNLERLNEQEEADGVHNTLAIVENLTEIDSEFLAWLLKRLRGKSPFDPNKLYCSEILSILIQTENENRLLLGSL--------------VLLQQLAVYKRHDPASNEEQEYMQNLFNCLENRDRFLSGEGLQLMNLMLREKKMSRNGSLKVLDHAMAGQDGRVEILGLRTIFPLFMKTPKRNKQR--------LISADEHEEHVTSVIASMLRNCKGTHRQRMLAKFTENDHEKVDRLLELHLKYLAKVEAIDKEIDQQAK---NNYIKRLT-GGLFTLQRIDYILLEVSATGDTVKQRVLQIL-------LRGASMKTIRSIMREYAGNLEQEQNHILSLVDRF................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 581
52 -9.950[TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family  ali follow..  9  561WSQHCSNFNKESMLSLREFIMKALASTSRCLRVVAAKVLPIFIKGPNNLDALIFNTLK-ILAVENTAILETVILSWISLSRVVEEEELHFVLLEVISS----VINSGIFYQGIGLSALQQIASTQLLSPYWPTVSVAI-SEGDFLIRTQAYTLPFLVLTKATLCLTNMHKILASLLTTDHPNLEESVMLLLSLATSDFEKVDLTSLLRS-------PISITVELLQLYQNDVPHEKIENALRKVAMIVSQVVNDEDLSNKELLYDFFNNHILGILAEFSNILNDLKGKTSINEKIKTIVGIEKMLSLCGGAVKLGLPQILSNLQSQNEHLRFYAIKALILATKEPEYSSIAGLSLVILPPL---PYLEPQEAELVIQIFDFISSDTHKCLQGLKWAIIKCLTNENEPVCYLGLQKLELFFQAKVDISNEVLDQLLRCL-ASTNMQISYLAAKNLGELG.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 1107
53 -9.490[S] COG5543 Uncharacterized conserved protein  ali follow..  8  484.............RDLSRLMIDRLKDPYDDIRNLCLKILLSYFISDSDAYFLFNHGLELLNAVRSHECDGGAKTIYLCNHFMEKSVPGSVLANTILNRLKSNIEHAKTSLLEAALIQLTYIELIKASETIWGLIKDVLCDDSP-LKETSSL-LTVLLTKCLFTLNYYGELMMTWLWEIRHRGAFTSVYPCFIEYCSFLFECNKHEISEL---PDPWLHKNLSVIQEKSSFITRRSGGIPLSITAILVAGKDKREQLIEQTVISLISIAKQPVEQKNI---------AGQFDLPQVHAMNTLKTIFTEHREYLEPAIALSIEGFSHELWPIRNCSVMLFTALINRSKFPTLHDYLLRELEVSVASLSSNDQPSTGLYPILNMFSRLQYAQLSQFEPLIFKCTASRICKVREIASLSLTCLLD--CSKMTTFIVSQLKGVAGLQQNEIHGKLLTI....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 1025
54 -9.180[T] KOG0403 Neoplastic transformation suppressor Pdcd4/MA-3, contains MA3 domain  ali follow..  10  140.DSPVSDPLNDYKKSVVSIIDEYFSTGDVKVAASDLREL--------GSSEYHPYFTKRLVSMA------------------DRHDKEKEMASVLLSALYADVILPDQIRDGFI-------RLLRSVDDLAVDILDAVNVLALFIARAIV------------LPPVFLVRSKKILPESCKGFQVIVTAEKSYLSAPHHAELVEKKWGGSTHTTVEETKKKISEILKEYVENGDTYEACRCIRELGVSFFHHE---VVKRALVLAMDSPTAESLVLKLLKETAEEGLISSSQMVK--VAESLDDLALDIPSAKKLFDSIVPKAISGKLRQYKKDTVNIIQEYFLSDDIPELIRSLQDL---------GAPEYNPVFLKRLITLALDRKNREKEMASVLLSALH-MELFSTEDFINGFIMLLESAEDTA---IMDASNELALFLARAVIDDVL......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 558
55 -9.150[C] COG5231 Vacuolar H+-ATPase V1 sector, subunit H  ali follow..  8  1MGATKILMDSTHFNEIRSIIRSRSVAWDALARSEELSE---------------ASTAKALESILVKKNIKTLIPLIHLLSTSDNEDCKKSVQNLIAELLSSDKYGDDTVKF-----------FQEDPKQLEQLFDVSLKGDFQTVLISGFNVVSLLVQNGLHNVKLVNNNLINILQNIEQMDTCYVCIRLLQEL--------IPEYRDVIWLHEKKFMPTLFKILQRA-------TDSQLATRIVATNSNHLGIQLQYHSLLLIWLLTFNPVFANEDFLDLLKLVKITIKEKVSRLCISIILQCCSTRVKQHKKVIKQLL---------LLGNALPTVQSLSSDEELRQDISNLKEILENEYQELTSFDEYVAELDSK----IDEFKKDNYKIFRQLIELLQKQEKIIIQVALNDITHVVELLPESIDVL-ADIMELLNH-SDSRVKYEALKATQAI................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 472
56 -9.030[U] KOG2034 Vacuolar sorting protein PEP3/VPS18  ali follow..  8  314VKVVNRISEQIIEELQFDITSDSVSRGIIGLCSDASANVFYAYD----------SIFQVSVIDEGRDMWKV-YLDLKVYAAALANCRDPLQRDQVYLVQAESAFTDKEYLRAASFEVTLKFISINEPEALRTFLLHKLDNLSKDDKCQITMISTWATELYLDKINRLLLEDDTAIENSEYHSVIQEFRAFMSDCKDELDEATTVKILESYGRVEELVYFANLEIVVLHYIQQGEAKKALEVLQK-----SSVSVELQYQFAPELIMLDAY-----ETVESWMANKNLNPRRLITAMMRYSSGPHAKNETHEVIKYLEFCVHRLHNEDPGIHSLLLSLYAKQEDDGALLRFLQCKFGKGRENGPEFFYDPKYALRLCLKIYSMMSMHEEAVALALQMVAKHVVKQEKGAKRENIRKAIAFLKETDGLLK--IEDILPFFPDALIDDFKEAICSSLEDYNKQIEQLKEEMNDATRGADNIRNDISA........................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 828
57 -9.020[S] KOG4262 Uncharacterized conserved protein  ali follow..  10  32.................RKISFLASSVKFGNQKRYQDWFQDKYFATPESHSLRSDLIRFIMLCSDIIPRKLSLFYDWLFFDPAKDNNIEPGILVMYHSIRN-----HPFVSSTLLDFLCRI-TKNFFVKHEDKIRIGVYNSLKLILEKQVIPNLQPLFESPKLDRELRNLIRDNFRECENMDLHETGLINIKKPKVELAEAIAESFDAFVTKRNSYTWEAFLKDFRPLPASAFEEFQLNYVISNTVLILKHLAKSISYPLYGLFRFLYENDEKSKKPFQTLLRQICDAADEKIGNCLLRDLDLLEKENTNIFLWLLPDIYREFKSIATN-NTDLLRITLRCIDAKNVRDILYSIAQ--------------FKQDGLIDCIRQSLEFETYEQFCLRCIQDILPELEAGSHPEALSHFLLLLKNEE--TNEIIRLMLSRESKSKGDPFVTSALWCQRYEEKLSEIIASLLTSKYPS---------------------------------------------------SPNKRKRPPKGISVSTSTPSADQVLNHLEHYRRSCRHGTGTGLYVHDMMQRALQSAYSHSNDSTKKQFCDLFALAAEEDTTVGRRGGSGRGRKQPGSKKDVNNHGTSKKNPEMVKTIYSSDDNSSEEDWSKSKILQTAKRRKKANNDS........................................................................................................................................................................................................................................................................... 756
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.