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Query: [BD] COG5098 Chromosome condensation complex Condensin, subunit D2, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSGFSLSEYLTKFQTTDRESYPRLQDPSRELNVIIDQLAVSPEQIDASPDSLEALIDLCHDFPHLTPKLQTQLSYLISSSLSNLSKDIKANLSSNVNFTEIGGLIPQWKRHLEEYGYLIQVLLTFLQDELHKVSSQSTNLNRSAKNSKNDSANVELFKRDCNQMENLLESITKLLEINLSKIFQTTPEKDLFIGLFTRPLFVLLEIEPVTKVSSLKMFIQRILAMCVKNHGQSSSIQSSLMTNLTYFLHLSVFNAELLKLLNDEYNYPQLTEDILKEISTRVFNAKDTTGPKAISNFLIKLSELSPGIMLRQMNLVITLLNNSSITLRCSVVEACGNIVAELAQDPQTMEHYKQQIAVLIELLEERFQDSNPYVRTKAIQGCSKICDLSSKFNKSKAKFTSLAVRSLQDRSSLVRRNSVKLLSKLLLKHPFKAIHGSQLRLSEWEEYLKGSESQLNSTLKKVESQETLNDTIERSLIEEEVEQDEGQCRTELEGSFNKSAELSRIENEVENINATNTSVLMKLKLMIVYYKDAISFIKEIHKSIELISNLLFSKNRNEVLESMDFLVLADAFDIELSEFGIKKMLHLVWMKGTNDEGTSISVHLIECYKQLFLTAPDSCNMQEKAAHIAKNLINLSIGASIADLASLEQLLGMMYEQKLIDQHVINILWAIYNSASKASMQKEQNVNNRDSEKGFSKEQIHGSIIILGMLSLADNEIALKGLESLLNIGLGAVGLKDLTLCRYSCLALERMVPKRSTIITKAINQELEDVAVKKLYAIIINYTKDNEYYPMCEQALSALFTISSKPDILATDLIREKTMMTFGKPEEEDSILSLEQSSRVVSLSQLLFIVGQVAIKTLVYLEKCEAEFKKRKIEAETRNGKVKNQGADVTNTTQDNGGDKELEMIGGTNEDDFTDAIQFVKENELLFGEKSILGKFCPIVEEIVSNSSRFSDPMLQRTATLCLEKLMCLSSKYCEKSLPLLITVMEKSPDPTIRSNAVLGLGDMAVCFNNLVDENTDYLYRRLHDENLMVQRTCLMTVTFLILAGQVKVKGQLGEMAKCLDNPDQGISDMCRLFFTELASKDNAIYNGFIDIFSNLSSDDLLGKESFKKIIKFLLTFIDKERHQKQLNEKLVGRLRKCETQKQWDDIAFVLNNLPYKNEDVTALLEQGFKVVSAKELast
1 -232.000[BD] COG5098 Chromosome condensation complex Condensin, subunit D2  ali  100  1MSGFSLSEYLTKFQTTDRESYPRLQDPSRELNVIIDQLAVSPEQIDASPDSLEALIDLCHDFPHLTPKLQTQLSYLISSSLSNLSKDIKANLSSNVNFTEIGGLIPQWKRHLEEYGYLIQVLLTFLQDELHKVSSQSTNLNRSAKNSKNDSANVELFKRDCNQMENLLESITKLLEINLSKIFQTTPEKDLFIGLFTRPLFVLLEIEPVTKVSSLKMFIQRILAMCVKNHGQSSSIQSSLMTNLTYFLHLSVFNAELLKLLNDEYNYPQLTEDILKEISTRVFNAKDTTGPKAISNFLIKLSELSPGIMLRQMNLVITLLNNSSITLRCSVVEACGNIVAELAQDPQTMEHYKQQIAVLIELLEERFQDSNPYVRTKAIQGCSKICDLSSKFNKSKAKFTSLAVRSLQDRSSLVRRNSVKLLSKLLLKHPFKAIHGSQLRLSEWEEYLKGSESQLNSTLKKVESQETLNDTIERSLIEEEVEQDEGQCRTELEGSFNKSAELSRIENEVENINATNTSVLMKLKLMIVYYKDAISFIKEIHKSIELISNLLFSKNRNEVLESMDFLVLADAFDIELSEFGIKKMLHLVWMKGTNDEGTSISVHLIECYKQLFLTAPDSCNMQEKAAHIAKNLINLSIGASIADLASLEQLLGMMYEQKLIDQHVINILWAIYNSASKASMQKEQNVNNRDSEKGFSKEQIHGSIIILGMLSLADNEIALKGLESLLNIGLGAVGLKDLTLCRYSCLALERMVPKRSTIITKAINQELEDVAVKKLYAIIINYTKDNEYYPMCEQALSALFTISSKPDILATDLIREKTMMTFGKPEEEDSILSLEQSSRVVSLSQLLFIVGQVAIKTLVYLEKCEAEFKKRKIEAETRNGKVKNQGADVTNTTQDNGGDKELEMIGGTNEDDFTDAIQFVKENELLFGEKSILGKFCPIVEEIVSNSSRFSDPMLQRTATLCLEKLMCLSSKYCEKSLPLLITVMEKSPDPTIRSNAVLGLGDMAVCFNNLVDENTDYLYRRLHDENLMVQRTCLMTVTFLILAGQVKVKGQLGEMAKCLDNPDQGISDMCRLFFTELASKDNAIYNGFIDIFSNLSSDDLLGKESFKKIIKFLLTFIDKERHQKQLNEKLVGRLRKCETQKQWDDIAFVLNNLPYKNEDVTALLEQGFKVVSAKE 1176
2 -31.600[A] COG5181 U2 snRNP spliceosome subunit  ali follow..  9  92VRQYEAPKELLNEYADESYDPMQERQSKKQIQDRESDYQKQRYDRQLTPTRVDAFQP--SNGRSYAEVMRQVELEKEERRVHMELNQRRREGTLKEVEEEESISDKKRELELNNTEISQKPKRSRWDQAPPSVTQVSTTKRRSRWDKAPENFTISEHVIENGISEDLINKEVNVVEEKLR---VRLLTEEELNELLPSEGYAILEDLAFFKQEDVKYFGKLLKVEDEAKLTIAELRERKILRLLLKVKNGTPPMLRQLTDQARDFGAAALFNQILPLLMERTLEDQERHLVKVIDRILYKLDDLVRPFTHKILVVIEPLLIDEDYYARAEGREIISNL------------AKASGLAHMIATMRPDIDHVDEYVRNTTARAFSVVASALGVP-----ALLPFLKAVCSKKSWQARHTGVRIIQQIAL-------LLGCSILPHLKNLVDCIGHGLED-------------EQQKVRIMTALSLSALAEAATPYGIEAFDSVLKPLWSGVQRHRGKSLAAFLKATGFIIPLMEPEYASHFTRRIMKILLREFNSPDEEMKKIVLKVVSQCASTDGVTPEYLRTDVLPEFF-HCFWSRRMASDRRSYKQVVETTVVLAQQVGSRQIVERVVNNFKDESEPYRKMTAETVDKVIGSL-GVSEIDERLEELLLDGVLFAFQE-----------------QSVEEKVILTCFSTVVNALGTRCKPYLPQIVSTILYRLNNKSANVREQAADLVSSITIVLKACGEEALMRKLGVVLYEYL---------GEEYPEVLGSILGAIKAIVSV-QPPIRDLLPRLTPIL-------RNRHEKVQENTIDLVGKIADRGSEYVSAR--EWMRICFELIDMLKAHKKSIRRAAVNTFGY---SKAIGPQDVLATLLNNLKVQERQNRVCTTVAIAIVAETCMPFTVVPALMADYRTP----EMNVQNGVLKSLAFMFEYIGEQARDYVYAITPLLAMDRDAVHRQTAASVIKHLS--VEDAMIHLLNILWPNILEESPHVINAVREGIDGIR--NCIGVGPIMAYLVQGLFHPSRKVRNTYWTSYNSAYVQADAMVPYYPHVDDDQFN.............................................................................. 1177
3 -31.500[BD] COG5218 Chromosome condensation complex Condensin, subunit G  ali follow..  12  1.............................................................................................................................................................................................................................................MSCIQIISSSQTSIAGHRKLCNKLFTLRTQEGFETDILRALNIILTVKKGNSNADRVLRFLVTFVNYLIDIVQPILKHILRGLDAKDKTVRYRCCQIIARVV------NCVKEIDDDLYNTLKEKLLSRVLDRESIVRLEAVVALSRLQEDTG---DEENDVRNILLFLLQDPSSEVRRSVLLNIE-------------------------------------------------------------------------------------------------------------------VSNSTLPFILERARDVDAANRKCVYARVLPFRYLSIKKRVRILKWGL--------NDRDESVEKAAADMLAYQWIE------------NADNNLLELLERLDVSNNSDVAVLAIKKFFDVRVDSLSQLEFPEQFWLELTAESSLLARTFNEICIEKNYTDLLDKMPEVVQLT---------YYIERQYVSLRDKSSYDESCFIIEQLLYIGLSQDMVDEIGRR--------KLLKSLTNSLSTMALPDSLISLHIELLRKLCSSENDFCSLLVEIITEVFEQGHSQNQTEEQGNSNAPEL--------------------------------NKNDYEGEEITVSQKSPSPSLPPNELNEPEPDDMDGYKEAFNELRCLSYVQC-ENITSSLNENLYMVDMLKTLIIPAVRSHDLPIREKGLECLSLVCLLNADLAFENVPLYLHCYEKGSVV-LKCTAIRTLTDMLIQHGKAKAISSILFEALGEFENAELQTLGAEAIAKLLVILHYRDELFLKPLIIQYFEPNHALRQVLGYFFPVYAENQWRIATIFCDALLSLDLDEDDVQLSIGHIAQQMLDWTDNEKLYEHLANMIFESLPNASEGKERKFMISLLGKLKIPTDLPSSDYQRTKRKLET.. 792
4 -28.100[YU] KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily)  ali follow..  9  7....................................................................................................................................................................QHELEQVIQLLQHAHSTDRDVQRNVQVQLVQLNEYLVYILSDMKEMIDATSRSLAGLLLKNNIRAKDVKFFVRTTCLKSIGDQELIRATVGIIVTTIVMEENMCD--PDLLDTLATV--MQPDELMQEGALGALQKVFEDSADRYESEMPKLLVFYEHHAAKMRALAMNCVNCIL------MVNNDPIDFAIDQFLTSLFARHNDNDEEVQKQLCRSLTLLLDT----MPHLPNVIEYIIKKTQDHNESIALEACEFWLSIAENSDICRTMVLPHLDKLIPVLLGSMRYSETDPALKANDEDSSVPDREEDIKPRFHKSKQHGLGGLVESDDEEDEDDDDDGGGDWNIRRCSAASLDVLASIFG--------KDLLDKLFPLLKDTLMNDNWLVKESGILALGAIAEGCMDGVVPHLGELIPFML-AMMFDKKPLVRSITCWT---------------------LSRYSSHIASDENFRQQFFKDVLANLLRC----------------------------------SLDGNKKVQEAACSAFATLEEEAGEQLIPFLGEILDQLVKAFQCYQAKNLLILYDAIGTLANSVGDALSHP---VYVQMLMPPLMEKWERLSDEDKELFPLLECISAIVSMGQSFLPYIQPVFTRCCSLIEKCVQQNQQHIMAPDQVEADFIIVALDLLSGLAESLPEHMDPLVANSKLVELMLFCSLDVTPDVRQSCFALLG-----------------------------DLTKACPERVLPQSSNFIFFLAQNLDPSKISVCNNAIWALGELA---KQFIGPIIEPLIVVINSQQNRTLLENTAITIGRLGQCCGEELAPHISRFVRPCCYKDNAEKESAFIGLCNMINMNPVGVLNDFIFWCDAIAVPTDSLRVLFAGILQSFKQQNNFILQLPPPLRERLSA.............................................................................. 879
5 -25.500[U] COG5215 Karyopherin (importin) beta  ali follow..  8  2.........................................................................................................................................................................................................................................................................STAEFAQLLENSI-----LSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLI--ENTKLEGRILAALTLKNELVSKDSVKTQQFAQREAKNQIKTNALTALVSIEPRIANAAAQLIAAIADIE-LPHGAWPELMKIMVDNTGAEQPNVKRASLLALGYMCES--------DPQSQALVSSSNNILIAIVQGAQ------------------------------------------------STETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMCLQLFAQNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHL---PGVVQACLIGLQDH-------KVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVAD-------------------MLMGLFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYL-NQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLPNARRELKPAVLSVFGDIASNIGADFIPYLNDIMALCV---AAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIFQ----------FIAQVAEDPQLYSEDATSRAAVGLIGDIFYGQDWVIDYIKRTRS...... 836
6 -24.700[YU] KOG1241 Karyopherin (importin) beta 1  ali follow..  9  2...................................................................................................................................................................................................................TSDIAMQLIAILEKTVSPDKNELLSAKNFLEQAAASNEFLKALSEILVNTANSAVARMAAGLQLKNHLTSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALG--------TENTRPSCAAQCVAYVAVIELPINR---------PMLIQTLVNKVVGSSEMHRESALEAIGYICQDFGVMENQSNDVLTAIIHGMVEPSNHVRLAATTALHNSLE-----------------------------------------------------------------------------------------------------FTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPVLVEKLTKQDECDDAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLECFVKSLK------------RVAANVCWAFIGLSDAETYALSPYFEYIITQLLETTDRSDGAQ---ANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLCATLQSVLRKVHEQDAPQISDAIMT----------------ALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLPTIHRTVKPQVLSAFGDIALSIGNHFLPYLSMVLDMLREYINELRESILEAYTGIIQG-EPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGDLCTYPLLDDAIITQFLAEGKRSKAQRTKMLCTWAVKEIK..................... 875
7 -18.200[S] KOG1949 Uncharacterized conserved protein  ali follow..  10  1......................................................................................................................................................................................................MLLECFININYIKKEEGRRFLSCLFNWNINFIKMIHGTIKNQLQGLQ--KSLMVYIAEIYFRAASGKILEAIENDCIQDFMFH--LPRRSPVHSKVREVLSYFHHQVEEMLYRLYPILWRGLKARNSEVRSNAALLFVEAF--IRDPNLHAIEMDSKIQKQFEELYSLLEDPYPMVRSTGILGVCKITSKEMMPPTILIDLLKKVTGELDTSSADVRCSVFKCLPMILDNK-----------------------------------------------------------------------------------------------------------HPLLEQLLPALRYSLHDNSEKVRVAFVDMLLKIKAVR---KICPMEHILVRL-----ETDSRPVSRRLVSLIFNSFLPVNQPEE------VWCERCVTLVQMNHAAARRFYQYAHEHTACTNIA--KLIHVIRHCLNACIQRAVREPPE-----DEEEEDGREKENVTVLDKTLSVNDVACMAGLLEIIIDRSMENNKEAKLYTINKFASVLPEYLKVFKDDRCKIPLFMLMSFMVPPFSCGVISTLRSREEGAVDKSYCTLLDCLCS-----VGHILELVDNWLPTEHAQAKSNTASKGRVQELALVYIEYLLTHPKNRECL-LSAPRKKLNHLLKALETSKADLESLLQTPGGKPRGFSEAAAPRAFGQHKFCSEGKVYLSMLEDTGFWLESKILSFIQDQEEDYLKLHRVIYQQIIQTYLTVCKDVVMVGDHQFQMQLLQRSLGIMQTVKGFFYVSLLLDILKEI-TGSSLIQKTDSDEEVAMLLDTVQKVFQKMLECIARSFRKQPEEGLRVSDVEELTPPEHLSDLPPFSRCLIGIIIKSSNVVRSFLDELKACVAS-NDIEGIVCLTAAVHIILVINAGKHVREVAATVHRKLKTFMEITLEED-----SIERFLYESSSRTLGELLN...... 887
8 -17.800[OZ] COG5234 Beta-tubulin folding cofactor D  ali follow..  10  1.........MEEEESLEGIISIDESLITSRLSQILDDVLDDRSSSHSVEKLKDVAVKYLQFCQFQP--------TLLDKLLSKYVPNLASYLLKVKNI--------GKCNSITVILYQFCKI-----------------------------RGYKAVRVLFPVGVQYIKELYTLLNESSNNTWHFHYIVLLWLSQALNTPFPL---NSLDDSLDVKKTIYTIAIKYLENSGIDKEASCLVLSRLFSRDDGLDLLLGFLHHCESSWFKRSIFYKILSSFLKICPRNDCLQTVDVAFQFLNVAREDL--------------VGQENSALRKLLCKCYTRLGIVLLPPDDSNEEVHIYLEVIVDFLLSSVSDIDSFVRWSAAKGLAKIISR--LPWNLAEQVIDAIIELMTENMFLNPIENTVNISITSPLVWHGAILFFAKLAGAGLIKYSKCLH----------------------------------------------------------------------------------ILPLIEVGLSYEVRYGTRVTGQSIRDASCYFSFYHCYSKSAIEGLQTNLILCLLQTVLFDNEINVRRAATAALFEVI---------RHASIPDGLSLISHINYVSVTDISCYGDLCMKVAHFPQFRSCVFQRLFTNLQH---------------------DVKVQQLSAFSLRQLSIKYPKELSIYLPPILD----YLSVGNADFIFGYTIGLASIIGG--LSISFPFDINRIHDLLSHKNLLSLKKFSRQQQTKIILGILKGIQQIFANDIRVDRAFFSEAFSVIIAAIDLQEETIIKDISDAYSVLVKFD-------------------------------------------------DMEETLEVLLDYIRKCSTSKEARIVYIILQNLPNISFRYQKKICKLLLDIYPQLHSIDYQAPVANALQNII-EKTESIEEFVKELLQVCSNDVGSWIRKPAMKAISSLLVKDEDIVWCCISYIIRQTFDKIDSLRGLAYQALEQIRVHYLIRRCEALTNIINRISFRNNPNMDGEVLNNISLLEIPNLRLQAFYGIT--VFTADGFGSDLAVKCFEFYLSY----------VYQLEDSFKKSNSRYGKRDLLQLYIDILSSEDEIARFYFPIMKSFT... 971
9 -17.100[U] COG5240 Vesicle coat complex COPI, gamma subunit  ali follow..  11  21...............................................................................................................................................................................................................................................................................VTVTQDARAFNSSSISPRKSRRLLSKIAYLIYTGEHFQEKQATELTKLFQHKDPSLRQFVYIIIKELS----------VVAEDVIMITSSIMKDTATGRETIYRPNAIRSLIRVIDANTVP-----AIERILTTGIVDPISAVASAALVSAYHLYPVAK-----------------------------------------------------------------------------------------------------------DIVSRWNNEVQDAVTSHNVGRKVASSPFFTSTLGYTPNASGISQYHALGLLYRIRRHDSIAMNK----------LLQLLVSNLGTVSNSHAFVMLIRYISSLMDQNTQFRDQMVPFLHKGDMVNLEVARNMVRL--KNISDDDLQPVVSVLKIFLSSHRSATRFSAIRTLNELAMTRPHLVHSCNLNIESLITDVN-------------------------------------------------------RSIATYAITTLLKTGNDES--VDRLMKQIVTFM--------------SDISDNFKIIVVDAIRSLCLKF------------------------------------------------------------------------PRKQDSMLTFLSNILCDEG---GYEFKRAAVDAISDMIKYIPESKERALAELCEFIEDCEYPKIAVRILSILGEEGPKASE-PTRFIRYIYNRIMLENAIVRSAAVSALTKFGLNAEDKFVQRSVKLTRCLEDADDEVRDRAAFSVKALEDRDAFLPVVKSDKIPSLPALER........................................................................... 580
10 -16.900[U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4, beta subunit  ali follow..  13  32...........................................................................................................................................................................................................................................................EAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELK-----KLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCI------------RVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINA-QMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHP------------------------------------------------------------------------------------------------------NSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRL-----SHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPE----------------------VQYV----------------------------------ALRNINLIVQKRPEILKQEIKVFF--------------------------------------------------------VKYNDPIYVKLEKLDIMIRLASQAN--IAQVLAELKEYA--------------TEVDVDFVRKAVRAIGRCAIKVEQSAE-------------------------------------------------------------------------CVSTLLDLIQTK----VNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADE--LESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATSDNPDLRDRGYIYWRLLSTDPVTAKEVVLS..................................................................................... 543
11 -16.100[S] KOG2149 Uncharacterized conserved protein  ali follow..  9  14......................................................................................................................................................................................................................................................................KGIDFKKIKRKLGRKLPPPNNATNTEIKSKAIILHEQSVAAERDGFATSTLLELKNRTGHPNAKVRKDALHGIKDLL------KHHPAELLSNKYATTHKLRELITDDDKLVRDDFYTLLTGIFLEDINKGLMVSSLMPYIFTAMTKSSIEVRLMAFKFFRLVLEFYS-------PTFSLYAEKILENYKDVIHNNHFYIQDKKKLKVVLLGLADCLSLLPCDQSDNESKKKGLLQYETLLACEQDAAKECVRFAHVSGILKEIVAVLINCKESFDCIRHILRSIGYAIKFSIRRHTQRHTKWLPSPEENTLMILDRDIASMLSKKLLGHENNFSVENNGVLTEIFLEVSEWSHLPCDLSNRFLEFIENALLGKITRSNSLDKTLLALLPFVPKDRDRRDNLMQAFTITFNNCKPESSLKLACISVVKDLIIPNGDILYPN-SLLNQLGDKHHVSTKVVLQLLLDLARVGCLNASPTFEEEIRSFFIPFHGEGEVPGGPFVSLPREVQ----------------------EVALCFLYYFIIDN--FSSPMLKAIVSCCLYE------------QLEPAVLYRIVEILQT-YIQITDHFSFFITLISRFKVVPEKLNSAIECDERKANCGTFKTLTNLVCSYLSEMGDSSLVLQILEKVFVEQIILKPALGCAILRMICALDSKPTRLSEISVTTLSEFLPGYLIDIVNCIPED---------RSYLYMQTCLYYLLPCYFLFDRSSKLTEQVLKRMRSMVSENVKALESVQDRESGRDSLNLI-----CIVSVILLMHNDVK---------VRKIISSSKSEIDLILQNVYTLQSSRSTSLT------------VEGKHMMKIAAERL............................................. 854
12 -15.200[U] COG5096 Vesicle coat complex, various subunits  ali follow..  10  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MSCWTLVQQDFLEAPSVDAL-SLESKNDYVKISAMKTILRVVINGDSLPSILMHVI--------------------RFVMPSRNKELKKLLYYYWEVCPKYNNDGTMKQEMILANSFRNDLQHPNEFIRGATLRFLCKLK---------------EPELLDPLIPTVRQCLEHRHAY-VRKNAILAVFSIYQVSNHLIPDAASLAEDFLAAESEGTRNALIVLFTIDPEKAKAWLLANFEQIPSLNASSLLVIIEFIRKVVLTKADGLEKLR-------------------------------------------------------FQSLLVSLTATNNSSVVFEAATSVINVF--DAESLKLAASRLLALADREADNNAKLIMLDRISQLAARDKSILEDLITDVIPFLSSSDFDVCEKAISIIMGLVSSRNVE----LNHFQKELTEKDDGRRRALTKAIHSCAINPHTAATAIQYLLSHISDFQSKSASSVLSFIKEVME--KFPDLRSSNITKLLLSLKELRAGKIFRGVIWIAGEYCLTEDDIRVAWKSIRASLGE.. 477
13 -15.000[S] KOG0212 Uncharacterized conserved protein  ali follow..  9  1.............................................................................................................................................................................................................................................................................MDNLLVRGLTHKLYDKRKA-TAYELERVVKGYLEND-RAVISQLANDFVYSPARGPNATFGGLIGLAAVAIAL------GPKIDSYMESILLPVLYCFNDSDSKIRYYACESMYNIGKVKGEVFRYFNLIFDVLCKLFADTEITVKNGAELLDRLI-------------------------------------------------------------------KDIVMQQAATYMSSAEDIKNFKEGPVSSSIQDVPVMSTEQPRMHTFSLSELVPLLSERLYVINPNTRMFLVSWIRLLDSIPDLEFISYLPFLLDGLMN--LSDPNESIRIVTSNCLYDFLREIQKIAKVKYHILQRDEESEPDFFDSMVRRNMSDAELKEISDYVESSLRDG-----SFILEAHIQIDYKRILEIIIDHLGSSVPLIQEKALKWLFEFIYIAPKDVLLQIPKVLENLLPLMSNDENMLSQNLVILVSKIMDIEFSGSETNNKDNSLSVDFRSLIEVLQKLLSNDN--ETRLCALEWVLLLQRRTGGKLINMHDPI-------------------------FQTLLLQLSD--------------------------------------------------------PSDLVVSRTLELLAHIAISHKSVNLVPFLKSLLQMFAEDR----KFLNSRGNLIIRQLCNYIEG--ERVYTSFAGILETEENLELASIMVEVLNNNLFTAPELYD-----LRKKLKQSAPKLQNNSIAVFSLCLLSNLLSVFAEIEFNIDMLIQLDKLVQLIESPVFTYM----------------RLQLLEPEKYPYLHKALYGILMLLPQSSAFRTLRDRLSSTPRTNTILANERLPRSRRDDPYWTD------LLERLKAVQLSH 743
14 -14.900[U] KOG1078 Vesicle coat complex COPI, gamma subunit  ali follow..  12  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAQPLVKKDDDHDDELEYSPFMGIEKGAVLQEARVFNDPQVDPRSQVITKLLYLLNQGESFTKVEATEVFFSVTKLFQSK----------------DTGLRRMVYLIIKELSPSSDEVII-----VTSSLMKDMNSKIDMYRANAIRVLCRII---------------DGTLLTQIERYLKQAIVDKN---VSSAALVSGLHLLKTNPEIVKRWSNEVQEGI--------------QSRSALVQFHALALLHQIR-----------------------------------------------------QNDRLAVSKLVGSLTRGSVRSPLAQCLLIQRPFYEFLESCLRHKAEMVILEAARAITELDGVTSRELTPAITVLQLFLS-SPRPVLRFAAVRTLNKVAMTHPMAVTNCNIDMESLISDQNRSIATLAITTLLKTGNESSVE----MKQITNFMSDIADEFKIVVVDAIRSLCVKFPLKYRSLMTFLSNILREEG-GFEYKRAIVDSIVTIIRDPDAKESGLLHLCEFIEDCEFTYLSTQILHFLGIEGPNTSDPSKYIRYIYNRVHLEN 472
15 -14.600[YU] COG5101 Importin beta-related nuclear transport receptor  ali follow..  8  1MEDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNP-------DAWQKADQILQ--FSTNPQSKFIALSILDKLITRKWKLL------------PNDHRIGIRN------FVVGMIISMCQDDEVFKTQKNL-------------------------INKSDLTLVQILKQEWPQNWPEFIPEVNVCENNMIVLKLLSEEVFDFSAEQMTQAIFKLCFQVLEQGSSSSLIVATLESLLRYLHWIPNILELLSTKFMTSPDTRAITLKCLTEVSNLKIPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLKATANGNDQSFLQDLAMFLTTYLARNRALLESDESLRELLLNAHQYLIQLSKIEERELFKTTLDYWHNLVAD----------LFYEVQRLPATEMSPLIQLSVGSQAISTGSGALNPEYMKRFKKHIYEEICSQLRLVIIENMVRPEEVLVVENDEGEIVREFVKE------------------------------------------------SDTIQLYKSEREVLVYLTHLNVIDTEEIMISKLARQIDGSEWSWHNINTLSWAIGSI-----SGTMSEDTEKRFVVTVIKDLLDLTVKKRGKDNKAVVASDIMYV-----------VGQYPRFLKAHWNFLRTVILKLFEFMHETHEGV--------------------QDMACDTFIKIVQKCKYHFVIQQPRESEPFIQT-------IIRDIQKTTADLQPQQV-------------TFYKACGIIISEERSVAERNRLLSDLMQLPNMAWDT------------------VEQSTANPTLLLDSETVKIIANIIKTNVAVCTSMGADFYPQLGHIYYNMLQLYRAVSSMISAQVAAEGLIATKTPKVRGLRTIKKEILKLVETYISKARNLDDVVKVLVEPLLNAVLEDYMNNVPDARDAEVLNCMTTVVEKVGHMIPQGVILILQSVFECTDFTEYPEHRVEFYKLLKVINEK-PAAFKLFVDAICWAFKHNNRDVEVNGLQIALDLVKN----------------MGNVPFANEFHKNYFFIFVSEHKSGFSKQALLLMKLISLVYDNKISPLYQEAEVPQGTSNQVYLSQYLANMLSNAFPHLTSEQIASFLSALTKQYKDLVVFKGTLRDQIKEVGGDP 1046
16 -14.200[D] COG5657 CAS/CSE protein involved in chromosome segregation  ali follow..  8  1..................................................................................................................................................................................................................................................................................MDDIPTLLARTLNPTTSKSAEEALKVWELQDSSFALKLLNIVAE--DTVDINIKLAASLYFKNYIKKHWDSEEGASISDEVAELIKREIINLMLKSTTIIQVQLGEVIGYIANFD----DRWDTLLPDLISKLSAVDMNTNIAVLSTAHAIFKR--WRPLFRSDALFLEIKYVLDRFCEPFLALFVQTNNLLRNGPQDAESLNSLFQVILLECKLFYDLNCQD-TYTNPSLEGDEGETNVLIKVKASICEIVELYTLRYEEVFTMLYDFVNVTWTLLTTLTPDEKYDGLVGKAMAFLTSVIRIDQVLQQFIELVVLP-------CLRESDEELFED-YVRRDLEGSNSDSRARSAIVLVGLLDHFDQKITSVVSTHINANLQQFSTNPSLFSAIAIKGQSTRLGVTSINENNIKPDLLQPAGVIHPMVLAEDIKYVFTFRNQLNSQQLIDIFPTILRFLEMPSFVVYTYAAIALDQLLTVRHNHVHIFTSLLIAPHILPALNQLIVESASTPQKLAENDYLMKAVMRIIIMSQEAILPAASLLLQHLTKITEEVSKNPSNPKFNHYESIGALIRSLSKSGPQTVSQLENALLPVFQNVLIEDVTESQLVEASGNEPLPDFVVNLIQPCLSPALWDSKGNIPALVRLLRAMIFRGPQIFISPVLGIFQKLISSKVNDHFGFDLLDRVFTVFN---ILAPYINHIFFLLLSRLKNSRTERFVLRCTIFFFFVASEGQLMTSIILPQAQKLALPLD---RKISALGLLRLLTCD-AIYENLIIPLLTCILDPFPQITDLKQYCATEMNLANRNMGGRLSQIISTHLPGDGQSV........................................................................ 959
17 -14.100[S] COG5543 Uncharacterized conserved protein  ali follow..  8  33.....................................IQSKSEDWYLKNGLFFRYYSFLKSSLE-NATLDGPSQVACLDTISVWLRRIFNACKQDPEISKYVWDTMELKFWTNLFSLPANKI--------------------------------------IPGLTGVQVAVKDVFSKSLQLYLLVCPSEDIKNDFLLDSLKHALHWDRHAKVV------CTAIQLLVKVTGAEADFFEQSLKLLKD-YSYAQAISSTILTVLTLRVETKWMNIWCPIILYEFYGNDRQVQAGMSSFLIPSLLGVSPGI----TVKFLSRLQNYPNVSKDARDAACLYALKIAKDSKIIKNLDLVKEHAFVKTLFKHPDIK---IQLACFRLIALCPNVSSPLSFEDFDCLESNIESFNVLDPDSRQILLKSMQDFFIR-----------LRASCHSIARTMRSRHSDKVALSGLLDRAMQFLTSFISVCKKHLYPTCNYQQVLVSLSFLDTLISFGLDDNVESSSIREAQHDFPFSMVIID---------RDLSRLMIDRLKDPYDDIRNLCLKILLSYKSLPGFISDSDAYFLFGLELLNAVRSHECDGGAKTIY-----LCNHFMEKSVPGSVLANTKVILNRLKS----NIEHAKTSLLEAAVNCPLQ-GYLIQLTYIFQSLSPTIVKNDNESWKNIVMELIKASETIWGLIKDVLCDDSPEGNLPDGEGEGGIVSNLEDTPAQLILLKETSSLLTVLLTKCLSLFDEEFTPFTLNYYGELMMTWLWEIRHRGAFTSVYPCFIEYCSFLFECNKHEISELPDPWLHKNLSVIQEKSSFITRRSGGIPLSITAIL------------------------VAGKDKREQLIEQTVISLISIAKQPVEQKNIAGQFDLPQVHAMNTLKTIFTEHRL---SSVSVEYLEPAIALSIEGFSHELWPIRNCSVMLFTAL-----------INRAFGSKKPKDAVNLGNNKGLSTKMFFSKFPTLHDYLLRELEVSVASLSSNDQPSILNMFSRL-ENEWTGLSQFEPLIFKCTASRICKVREIASLSLTCLLDCSK-MTTFIVSQLKGVAGLQQNEIHGKLLTIRAVLSCFFSKLTLQQVQEFY............................................. 1045
18 -13.800[U] KOG1058 Vesicle coat complex COPI, beta subunit  ali follow..  12  23..................................................................................................................................................................................................................................................................................EAQLKEKFEKGGDKERIEALKKLIYMILNGEKTSQSMLMYVIRFCLPSNEHTLKK-----VLLIFWECVPKTDSNGKLLHEMILVCDAYRKDLQHPNEFVRGSTLRFLCKLREPELL-----EPLMPAIRACLEHRHSYVRRNAVCAIFTIYKNFE-----------FLIPDAPELVTEYLEQ------------------------EQDASCKRNAFMMLLHVDQARALDYLSGCIDQVGSFGDILQLVIVELIYKVCHNNPNEASRFIRCVYNLLQSSSPAVRYEAAGTL-----VTLSNVPAAVKAAASAYIDLIVKESDNNVKLIVLDRLVAL-------RGSSSNEKILQGLVMDILRVLSSPGLEVRKKTLS----------------------------------------------------LALDLVSSRNVEDMVMFLKKEINKTATESNDENGKYRQELVKTLHAATIKFPDVA---------STIVPVLMEFLSDTNEK-----ASSYVLQFVREAVHKLPNLKNAILGALREGIPFIQSPT-------------IFMSALWILATYC.................................................................................................................................................................................................................................................................................................................................. 466
19 -13.600[YU] KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily)  ali follow..  7  4........................................................................................................................................................................................................................DPVVYQLQRAVSQDPIAVKDAEGHLNNWKKEPGFFGKLYSIFLDKQNDMSLRWIAIIQLRNSIDIIWRKNTKM----------SLLPEERDFI----CNALLGSIKSENLLSIQNALVVSRIA-----RLDYPTEWPSLFHDLLGKLQQSLGTGDYDVALRLLITLHHIIKAAGNRLLRSRQIFYKLAPELLTILQPILHSSLSSWMMILESSKEIKDSTLLSYMQISRYTLKACRRLVVFGFQNPSESEFSERMLAFCAVHQRKLLSMLGTMLQSSRSPIVVGECLEMAFAHAFLFNKPFFDFSFYSPCLTKFPATIDYISLHYDFLGQISSHLSSYKEKFVIMSLRVFILVIQEFCNTKSSHPETAQVLYNSFLVDNRINNLLDLLITKLLILWVLEQSTQDVEFNVRPCAEKLLCFFDAYGDIIVSPFKDMIYSVFECPKTLTQSFGVGYTQLKSIFPFAKWLQEAAVPNMASINDIGIRRRIAIFLSQWIEDSSSEQLLEVIYKLYCSFLNLTDPCNDAVVITTIDAFKTVLDDWNFSENS---LSIKENLFVHVLSLFKAFESVDARTSILSLLGTLLARAGEHVAPMESTIASLLSQLW-----DGWKKEPLLRARVLAVMHQFVNAIKAKSFEFSTFLYTVIEYCVNPESPEHVIFEADAMELWSTFLMYIQKLPETFTLLI--SQATSTLPFVLMIVSSYQLLDNTVLMKDYSFTIFEKLNDLLDDVKNETLQALCKTVCLLIIYESLLNSSLLSRLLLSIATNDKPQVLIEYLLVVSRISLREPELILKVCQTKNINIA-NHSKDRKLNTLALSSLLRTNHPDVLAVLDSIMNLWFS-----------VLSEVEEDANGDATIYYKNDDYSAVGFYLDETSEEMTRR---QLLLKDPVHSVNSRSFFISVFMFCRDANGGMENFQNQYLSTVNPALLEQFQSML....... 983
20 -13.500[YU] KOG2022 Nuclear transport receptor LGL2 (importin beta superfamily)  ali follow..  8  1.............................................................................................................................MDGNEIAHAKKLVYDLYSGSLSPSAIAATEKELQKAQRSQQGWNIGLFMLQ--------SKDVYEQFFGALT-LQMKINTQLETLSDKDLVQLFVQLLQKLLWDDGLPALVERKVICTLASLEKKEEASLKVIYCLFCNKLEFFNADMNAASVLNNLFPPASSRNAQLTASYINELLLELSFSIYTKEN------DALFNNVFRPCSNIIVSVLVFIFTNYSLDLSKEKNVAALEEAL-------------NCMIAISSYLAKASVSVQSVLPAFTECMDLTVNALDEVSEKAMNCLADLLANYS--NFITQPTIERLWTILTGPWGETHLQQELEDPDSGEENDYSFLNIVIGFAEAMLPQIIDHIQEEKSIRLLYILASLLSFPGYAIVEEKVSWR---------TLEFWTTLIEDFSMSKAATDPSKDEIFKQIAFSVVEKAWWKMLLPSPE--------WPSSSRDSFNSYRRDLGDLLESSY--------FGERLYAMYITTIENFFSDGTGSPQSLEVSFYCL-------CCILEYDTNDSDTLDAWLTRLFETSFAIKASAFQNPQLLKTCSQLLSSCSC---QNHPQYLNISLPVLFDALHISETSIQMTVSRSIHTLCTTCASHLLTEI-----DGFMAVVEELTPKLVYVPSVLEKIYSSVGYVTQRIEDIELRLMRLLNCILAQLQPSLYPNLEIFEN-------VLKSCLQSVAGVALSQSPIGESPIIDVEQSTQETTFWQQSCIAEFQAKLISFLTHSESM-------LQYSDVVGLICKIMIAGLNEVEPSPFSLPIVTTIQYFCDRFTEFPAAVLLTLGSAILTCPYGQTDIIDKVLIDMCSSIQNMNNIDITVELYHFFSIILQKHPSFLQLILNRAINLLGKPERLLESAAGQFIISFIHTDFVNAIRSIAKILLGFGGSRSSLPLLSDILGKLKAQNFSATRACLTQSLEEEG-SRNVSNEIKRRFLTDLLK-----ARIKDKVKQFWILCK........................................ 976
21 -13.400[O] KOG2062 26S proteasome regulatory complex, subunit RPN2/PSMD1  ali follow..  8  6............................................................................................................................................................................................................................................................................................SDNTSIITSAGGLMALLDEQERELQVHALLKIYEFIDQLWPEI-SDDVTKIEVMY------EDHSFPERELAALVVSKVYYYLGEYDEALL--------ALSSGPKFLHDKNSDYKETLIFKCIDMFIHKSAELYGIFQKCYAKNEWRHVLGIAIEAHRLDIIEYILNADKETDLKPYVLELAMTVVLDIEFRNRLLRLLLSSFLTETEPDYFSVGKCVVHLNDASVAAKLLMKLSSQNDDKSLLTAYQLAFDLEDSAPQEFLNSVMDLLPSPSVANSEEDANAD---SKKEDSSPCGYIIRILSGEQTVKYDREFLYAHNNTDMLILNRTKDSLEARNSVFHNAVTFANAFMNFGTSSDSFFRDNLSWLSKNNWSKFTATAALGVIHRGYYNQAMNILRPYLPEEDAPSSSTYSEGGAFYAMGLIHANHGR------GVTEYLREQLKHTEDEIVQYGLLLGIGLTGMASR-----------DETLYESVKTILFNDNAVAG--SAAGISMGLIM-LGTASSAAIDEMLQYAHE-----------------TQHEKIIRGLGIGIALIVYGRQQEADGIIKELNN--------------------------------------DLDPTLRYAGMFATALAYCGTSNS-----KIVRDVLHISVSDVNDDVRRAAVCALGFICFKDPNALIS----TVELLVDSYNPHVRYGSAIALGIACANSGS--NAALDLLSRLVEDATDFVRQGAMIAQAMILTQHNDQLNSKVSGIRKHFEHEDALAKLGATLAQGIIDAGGRNV------TIALQTATGSLKLSAIVGLTVFLMSLSFSPTALIGLDKNLNAPKFSFISNVRPKLFAYPPKSVQPTAKTVQKVETAVLSTTVKAQ 823
22 -13.400[O] COG5116 26S proteasome regulatory complex component  ali follow..  8  6............................................................................................................................................................................................................................................................................................SDNTSIITSAGGLMALLDEQERELQVHALLKIYEFIDQLWPEI-SDDVTKIEVMY------EDHSFPERELAALVVSKVYYYLGEYDEALL--------ALSSGPKFLHDKNSDYKETLIFKCIDMFIHKSAELYGIFQKCYAKNEWRHVLGIAIEAHRLDIIEYILNADKETDLKPYVLELAMTVVLDIEFRNRLLRLLLSSFLTETEPDYFSVGKCVVHLNDASVAAKLLMKLSSQNDDKSLLTAYQLAFDLEDSAPQEFLNSVMDLLPSPSVANSEEDANAD---SKKEDSSPCGYIIRILSGEQTVKYDREFLYAHNNTDMLILNRTKDSLEARNSVFHNAVTFANAFMNFGTSSDSFFRDNLSWLSKNNWSKFTATAALGVIHRGYYNQAMNILRPYLPEEDAPSSSTYSEGGAFYAMGLIHANHGR------GVTEYLREQLKHTEDEIVQYGLLLGIGLTGMASR-----------DETLYESVKTILFNDNAVAG--SAAGISMGLIM-LGTASSAAIDEMLQYAHE-----------------TQHEKIIRGLGIGIALIVYGRQQEADGIIKELNN--------------------------------------DLDPTLRYAGMFATALAYCGTSNS-----KIVRDVLHISVSDVNDDVRRAAVCALGFICFKDPNALIS----TVELLVDSYNPHVRYGSAIALGIACANSGS--NAALDLLSRLVEDATDFVRQGAMIAQAMILTQHNDQLNSKVSGIRKHFEHEDALAKLGATLAQGIIDAGGRNV------TIALQTATGSLKLSAIVGLTVFLMSLSFSPTALIGLDKNLNAPKFSFISNVRPKLFAYPPKSVQPTAKTVQKVETAVLSTTVKAQ 823
23 -13.300[U] KOG2081 Nuclear transport regulator  ali follow..  8  1...........................................................................................................................................................................................MDTYSVDVVYQAISALFQGNNPKEQEKANKWLQDF-----QKSIYSWTIADELLHQKRDLH-------------ANYFAAQTMRNKIQNSFSELPPHTHES--RDSLITHIGQIDEQTDNVIVTQLSLAVADLALLMASWREPINDLLVTL--------APHQCAIWPLLEVLKVLPEEIDSRYLRLGANRREEVHKQLDASA---ECVLKFLCMCLQREDLDQQRVWNAALRTYSAWLV---IHAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCALLSCINTRQDGASDPESSFEAQLFGAVCMLETPYHLSVAHEDTDKTINYCRIDAFFYDLLADAQKPHYSLKGLDLVLLCVGHFDYEVAEITFHLWYKLSEDLFQRNEDKIERLISALFRHEENNNFFDFRRKVSDLIKDVAF-----------GSGACFKQMFHILQAPETTWESTEAAL------------IMQNVAKNILPD-ENEVIPKVVEAILNMSEQTHIAVRYTAILLIGELCENHPESLEAVLNFLLY-------QQKNGLAPAAAIALTSICSACRQKMVCHI-----SGLVEIARSLDSFQINNDVAIGLLKGISLILTRLREQLQPALREIVGFQLQPLAQLVDSTGSTPQKGERTDVYWIDRACAIIRHTNPDVPDNVEHPTVAILNDAWQLISRVMDK-------------------------QSDLRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHHSCFLYVGSILVDEF---KSSECIGGLLEMLQAFIEPTFGLLQMENGLKNNPDTLLQSSLITPIFQCALIACSLDHREANSSVMKFFINLLVVELASQHGGVMNLIQASVFHSYMLVDVAEVLHELKQVGNERMQPFLAQALEALPKKVTATQQQLDEFSSTVLR-ADTTKAISQALKTFTRLFR........................................ 914
24 -13.300[YU] KOG1992 Nuclear export receptor CSE1/CAS (importin beta superfamily)  ali follow..  10  3.....................................................................................................................................................................................................................................................................LSDANLQTLTEYLKKTL------DPDPAIRRPAEKFLESV-EGNQNYPLLLLTLLEKSQDNV---IKVCASVTFKNYIKRNWRIVEDEPNCEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGRED----QKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKR--YRHEFKSNELWTEIKLVLDAFALPLTNLFKATIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFWEGNMETLQTDDEEEAGLLELLKSQICDNAALYEFQRYLPRFVTAIWNLLVTTGQE-VSNAIQFLASVCERPHYKNQNTLTSICEKVIVP-------EFRAADEEAFED-YIRRDLEGSDIDTRRRAACDLVGLCKFFEGPVTGIFSGYVNSMLQEYAKNPSLVTSLASKAQTQKHGITQANVNHILPDLKSANVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLINHLQAGSIVVHTYAAHALERLFTMRGPNNATLFTAPFVEILLTNLFKALTLPGSSE-----NEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMFEAICLSIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFIPYVFQVMSLLLETHKNDIPSSYMAWERTGNIPALVRLLQAFLERGSNTIASAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHDQYRKQIFILLFQRLQNSKTTKFIKSFLVFINLYCIKYGALEKIIIPEIQKVSGNVE---KKICAVGITNLLTECPPMMDTEYTKLWTPLLQ-----------SLIGLFELPEDDTIPDEEHFIDIEDTPGYQTAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHMLSTACPGRVPSMVSTSLNAEAQYLQGYLQAA........ 966
25 -13.000[S] COG5369 Uncharacterized conserved protein  ali follow..  10  1............................................................................................................................................................................................................................................................................................................MVAINDSTDSSFFKENPKIFKDEHELLRY--IVPFKNWVI------RPDRKEYAIRNGAPKLLLNLFSLENL-EKYQVFVVLNSLMSEDQDPFVQFLRDLLSVMQMISKRDSTPYGMLNITLKVFMLSFDKAAEYVTQLHSDSIINQMFDLYTLPLKEQPSLDVLRISNLSSKILHRLILYNSKVGDSPRFCSALFQITNRATQLRLYSRRRFWNDCSILITNSLGTLNAYLKQHVKSYKQREKTRLESNGHVSPRDMDLDEIENVFEGNKDKVANGDEYITQLFCLV-----RQFDPCIRLLSISCLVTLYAGILSKNQTKEIQMIVTPILIRLFFESREAKQIAPRILAIIINENEIMNAGFIDAAKYLLEYATKEEENEINFLS--------DELQSSAACECLLSLSRSVYILRTGLADAVSEPLIKLLSDPDTRVKSTATSAICNLVLKFSPLREK-----------------------------LTTNFIDTLISNISTKDS-----LRKKTVWVLRHVVFGDDETIQLEPLKKIGASKLVELC------------------------------------------------NDEDLGVQEQMLQVLRNFTCQKEESVDFLLKMVPMELLAKILLEKLESK----NPILIEPSIYILVHIAASDGELRQTKLLLLVKEIMLQEAQRLKPEQMSTNVSSPESDSEEMRPPFDIYEEDTYEPNSEILLAGIWLCINILWPKILQNLGFGECLQMLQNHSSPDVRERVKDALMYINVTD.............................................................................................. 729
26 -13.000[R] KOG1293 Proteins containing armadillo/beta-catenin-like repeat  ali follow..  10  1............................................................................................................................................................................................................................................................................................................MVAINDSTDSSFFKENPKIFKDEHELLRY--IVPFKNWVI------RPDRKEYAIRNGAPKLLLNLFSLENL-EKYQVFVVLNSLMSEDQDPFVQFLRDLLSVMQMISKRDSTPYGMLNITLKVFMLSFDKAAEYVTQLHSDSIINQMFDLYTLPLKEQPSLDVLRISNLSSKILHRLILYNSKVGDSPRFCSALFQITNRATQLRLYSRRRFWNDCSILITNSLGTLNAYLKQHVKSYKQREKTRLESNGHVSPRDMDLDEIENVFEGNKDKVANGDEYITQLFCLV-----RQFDPCIRLLSISCLVTLYAGILSKNQTKEIQMIVTPILIRLFFESREAKQIAPRILAIIINENEIMNAGFIDAAKYLLEYATKEEENEINFLS--------DELQSSAACECLLSLSRSVYILRTGLADAVSEPLIKLLSDPDTRVKSTATSAICNLVLKFSPLREK-----------------------------LTTNFIDTLISNISTKDS-----LRKKTVWVLRHVVFGDDETIQLEPLKKIGASKLVELC------------------------------------------------NDEDLGVQEQMLQVLRNFTCQKEESVDFLLKMVPMELLAKILLEKLESK----NPILIEPSIYILVHIAASDGELRQTKLLLLVKEIMLQEAQRLKPEQMSTNVSSPESDSEEMRPPFDIYEEDTYEPNSEILLAGIWLCINILWPKILQNLGFGECLQMLQNHSSPDVRERVKDALMYINVTD.............................................................................................. 729
27 -12.900[U] KOG1062 Vesicle coat complex AP-1, gamma subunit  ali follow..  11  8.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TRLRDMIRAIRACKTAAEERAVVRKECADIRALINEDDHRNLAKLMFIHMLGYPTHFGQMECL---------------------KLIASPGFPEKRIGYLGLMLLLDERQEVLMLVTNSLKQ----DLNHSNQYVVGLALCALGNICSA-----------EMARDLAPEVERLIQFRDP------IRKKAALCSTRIIRKVPDLAENFVNAAASLL--------------KEKHHGVLITGVQLCYELCTINDEALEYFRTKCTEGLIKTLRDITNSAYQPEYDVAGITDP----RLLRVLGQGDADASDLMTDILAQVATKTESNKNAGNAVLYECVETIMAIEDTNSLRVLAINILGRFL-------------------SNRDNNIRYVALNMLMKAITFDDQAVQRHRVTILECVKDPDASIRKRALELVTLLVNENNVTQ---TKELIDYLEISDEDFKEDLSAKICFIVEKFSPEKLWYIDQMLKVLCEAG--KFVKDDVWHALIVVISNSELHGYTVRALYKSVLTSEQETLVRVAVWCIGEYGDLLVNNVGMLGIEDPITVTES 509
28 -12.800[TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family  ali follow..  8  739..AYTLP-------------FLVLTKNKALIVRIAELSQSDVATLC--LTNMHKILASL---LATSDFEKVDLTSLLRSDPISITVELLQLYQNDVPHEKIENALRKVAMIVSLYDFFNNHILGILAEFSNILNDLKGKTSINEKIKTIVGIEK------KLGLPQILSNLQSAFQIKAWFSLILATKEPEYSSIAGLSLVILPPLFPYL-EPQEAELVIQIFDFISSDTHKCLQGLKWAIPTSLDSACFSL-KAKEIFCSLQNEDFYSELQSIIKCLTN-ENEPVCYLGLQKLELFFQAKVDELHDTLNLDLDQLLRCLASTNMQISYLAAKNLGELAKAQHIIKETVENGEESLKFILDFMQSQLQGFLAYALQEFLKVLIPFLTSK----TWMQLFSLKLMEYAHSQNAVVKDQEVNIPCFLL---PFL------VLNVILTESELEVNKVIEEFQLVINQPGPDGLNSVGQQRYTSFVDVFFKIVDYLNKWLRMRKKRNWDRRSAIARKENRYMSVEDATSRESSISKVESFLSRFPSKT-------VSLNCGFHARALFYWEQHIR------------------ATAPYAALESDYRVLQEIYAGI--DEIEAVSLNFHDYSFDQQLLLHENSGTWDSLSCYEIIIQKDPENKKAKIGLLNSMLQSGHYESLVLSLDSFIINDNHEYSKMLNLGIEASWIFYQYLRKDSFAELTERLQPLYVDAATAIANTGAHSAYDCYDILSKLHAINDFSRIAETDGIVSDNLDIVLRRRLSQVAPYGKFKHQILSTHLVGYEKFENTKKTAEIYLERKNGQFQRAFNAILKAMDLDKPLATIEHAQWWWHQGQ---KAISELNFSLNNNMFDLVDEHEERPKNRKETLGNPLKGKVFLKLTKLGKAGQLGLKDLETYYHKAVEIYSECENTHYLGHHRVLMYEEEQKLPVNEQSELVTRIINEFGRSLYYGTNHIYESMPKLLTL-KDDGEKYFREHIISSRKKSLELMNSNVCRLSMKI---------------LVALSQMISR---------------VCHPNNKVYKILEHIIANVVAS----GETLWQLMATIKSTSQ-----------------KRSLRGKSILNVLHSRKLSMSSKVDIKALS--------------ILITEKLINLCNTR 1993
29 -12.800[D] COG5537 Cohesin  ali follow..  9  85...............................QEFFLKLLDIDMPLEQLSQHY------FEDYKSNSADFMLTFINFALVASGCQPFVTNFDVQDVDSIPET-----------------LSQVNRSSFQKSSCAYTDYLYTSNSKEAKT---------------RIRFQLFLVEFISKVEDAFL-----GDSFMETTKAWIFTMTTSP----------MLVRHTATTI-----CCDIMRCLCLIVNKLSEKSNQTAEILVLRDLTSRFIDMIHDICDSVLFSRIHDIRASIRIVCVTALYDCCQLLPTYLINRIRHSGWGLSDAESQIRKISLKIIDYLSSH--EPEKDQDFVVDFLDRFSLRIVEICRYDIDSVRSVALKTCEKLMEKISLNGKCINIVSSC----IFDGKPQNRISTMRILVAHTNERYANYCEAKTATISLSKLLRREKIPLLVSSFESLFKMNALLFILEQGFESWFRDSSDHIFSRVKDDDKFVYQSQENNFYDADFIREYDMNNHQLIEESMHSIHTNSQLLASWEDVAKLLLFDAKDTNSVLNPCIPSNAVIEFSSIYLHYFATHISKRSKKPGKRLEDEVVNQQQAMLRNLPLLLQKYRESCVSSYFFIKCV-EQIPDELLYKREFHKDFSKLYKEILDNSTTVNFLMILCSRFFHRLAVNKVVQEDILFAIDNVYNDLAESLHEQL........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 705
30 -12.800[O] COG5656 Importin, protein involved in nuclear import  ali follow..  9  3.........................................................................................................................................................................................................................................................................QEQAILSCIEQTM------VADAKIIKEAEQQLFEF-QKQPGFTSFLLNIVSD--DNFALNVRLSSAIYLKNKIHRSWDTKREDGIKADEKLSIKERLIETLVCENNHIRPILTETINGILVGQ-------WDLAPIIKNLLSSGDASYIYPGLLLLFQLCKAHRWDMVGSRDYIDSVIEELFPIVEGIASNIGSQTDYRSNEILYLILKSFKYACLNNLPQYFSQPERIMSLYLCSKPLPVEVMELDPADRSLDKRVKVNKWGFGNLNRFLQRTKEFIDYIFNTIVPIILREFFKDIEAWGNNSLWLSDSSLYFLISFLEKCVTIDQEPHLQIIFENVI--FPCLCANEQSIELLEDDQEEYTRRYFDINREGSTPDAASADFIFLIGSKRPEKLNNILPFINDIFTRFDANSSDIN------------MAFKEEGALRTLSNLFSFIDE--PSVLENIFGHFIVPLLSQD-FLVARSLETIALYSEE------------KDMNILSQLFELTYTNFLNSNVLPVQIEAADAIKCLIVSNPQIHPAVVPGMMEKLLKLSKIFEIDI-------SEVMEALVERFSELSPFAKDLASNLVEQFLRIAQALVENPSETYSASDQEQEIQASGLLQTMTTMVMSMNKVPLIESLAPVVKFVVLHAQISFITEAVDLLDALTISSHLLYNQIAPPIWELFFETIVMTGFPQDQTYVQPLLEILSAESEVDYDIEHVMQILMYFALSMRDIPLFSKAIKVSTNDELGLDSKCIVKLGLANLFAKIMENEGFTINFFTNWFNEAIKLQVLVILTLLKMPEVPNSVSPLLNNLTNKLVTEGKSLEGDLTPEEEEEYFIECDDDMKETVLDQI-QEVHTFFKNLQNEDAGKYEKIINYLDESKRDSLQVILEFVSQH. 944
31 -12.700[U] KOG1077 Vesicle coat complex AP-2, alpha subunit  ali follow..  10  1.......................................................................................................................................................................MRGLAVFIS-DIRN--KSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHD------------------IDFGHMEAVNLL-----------------------SSNKYSEKQIGYLISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGS--------RDMAESFSNEIPKLLVSG--DTMDVVKQSAALCLLRLFRSSP-DIIPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRNPDEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEA-INLIIHSDSEPNLLVRACNQLGQFLSNRETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDV--SVRQMAVDLLYAM---------DRGNAEEIVQEMLNYLETADYSIREEMVLKVAILAEKDYVSEEVWYRVIQIVINREEVQGYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDSRSAPLVQFKLLHSKYHLCSPMTRALLLSTYIKFINLFPEIRTNIQDV------------FRQHSNLRSADAELQQRASEYLQLSIVASTDVLATVLEEM....................................................................................................................................................................................................................................................................................................................................................................... 594
32 -12.700[C] COG1413 FOG: HEAT repeat  ali follow..  14  2....................................................................................................................................................................................................................................................................................................PVHMKLADFKTYKLEL----FFFSILVVLSYALFSGNDSGTGTESM------------------NYFWVPSTVMQSIAAVYAVFIAIFALSLQRNLDS---------IHSIANRLKPPLKIVSYTAVGSIYL--------------------NGLMLIIFSLHSPSELKIELMLFTSLLSLVASLIAIVYLSMEMLSDVSG-----------------------------------------------LKTSSEKFTYLTNLLRELEGWSSSGQMELSPGDMELCVQGLE------------DEKPEVRIAAAQLLGWL------------GDEQAVDALLRKLADKNPRVREAAVEALGRVGDENIVAE-LIGCL------------------------EDKNKGLRLQAVRALSRLGDER----------AVDPLVKKLEDKAPEVQAAAAEALGNLK---------------SQDSMDVLLKKLEESPMAGAPTEFQVQVLTALGKIGD--EKALAAILSRL-----------DSPYPDIRKHAAEALGNL---------------------------------------------------------------------------------RDEKAVPHLVKKL--------ADISPEVRNASVYALGNL--------ERAVSPLLRMLE-EPDPELRITAVYALGNL--------PQAISPLINMLDDDNPWVRKCTAEALGKI--------IKATDPLVKNLDDPDSNVRWAAAEALRMLDKRD-----LRKDSNGNL................................................................................ 508
33 -12.400[S] KOG4646 Uncharacterized conserved protein, contains ARM repeats  ali follow..  13  17.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LQALVTEFQETQSQDAKEQVLANLANFAYDPSNLRQL-LDLFLDSLSEENETLVEFAIGGLCNLCPDRHILHAGGVPLIINCLSSPNEETVLSAITTLMHLSPPGRSFLPELTAVVQCMLRFSLSASARLRNLAQIFLEDFCSPRQVAEARSR.............................................. 179
34 -12.400[J] COG5593 Nucleic-acid-binding protein possibly involved in ribosomal biogenesis  ali follow..  9  58.................................................................................................................................................................................................................................................HVSELETRGLLLLKEDSERFSETLGHGTADKRMLQTLISSGTTSDRISA-------LTLLVQESPIHAVKALETLLSICSKKSRNEATQAITTLKDLFIGGLLPDRKESFLKSFYFKYIQIIEALSFDALLFVKSQMVSTIYDLLKAKP---EQEQNLLKLLINKLGDKENKIASKASYSILQLEASHPAMKLVITKEIERFIFAPSTSRTSCYYTLITLNQTVLTHKQVDVFALEKEEVADAPTLEKKSLQSDSKNKKSQKRKKDEDLRKEAEENVNSRVISAVLTGVNRAYPFAEKFDKHMNTLFAITHTASFNTSVQVLMLIFQASASRDFISDRYYKSLYESLLDPRLTTSSKQSL------YLNLLYKSLIIDNNIPRVRAFIKRMVQVSAWQQPPLVTGLFHVMHQLVIATTALRSMFT.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 511
35 -12.300[YU] KOG4541 Nuclear transport receptor exportin 4 (importin beta superfamily)  ali follow..  8  26....................................................................................................................................................................DRFLEVSENILSFRPPISWKDLLENDEFFILFFKLHSKIRHDETLCT--KSMNCLIQLASLT-ASTKYVRMYISSLLELFAQGPSNWETFCLIINRLFLYRPLTSIMRHLTNQAMQKAIGEAEHEDHTSLALIYDAIVVLLRGRWRTCFSSEEEADAVDNELVKWPTLMIVNAFVSNLLAPVAKDEDDGDEDSEDRTLFMDLFNPLGAMICYSVGEFMENMATNLHTSLAEFTAMATTGSTGDMSRRLPMWQEDQHWLMLILAN-------------------------------------SIVGEEIDGACHVSGDVFDYTQKLFHTGRKFDETKKAQYLQMCIEQPTQDRAQYALEVDPFIIVMGELFAWASIEHDVFANASREMISP---ELCRSTFLCLR------------FLNAASSSVDCDKWNDYQGVSSENLPVM--------------PQSKEFSAILVRFV-------IKKVLAVLVNYGSEEKLCQDAIDCLLSLVESHASDIASSPELFEYLNSLDIARLPNRANLMKALVLIGAAAND-LSERFVSACDQPTRTDIDSQIVDYLQCFDGVAKASQSHSAPVLFKFLYAIIDKCVGLMRSRNQNELVVSNILQLILDVTTSIYIDNEDESNALYASLLQIVDTYKTDQFQRFSTFTADDEEKATDLALFIDILSNVLSKDFL-------------------------------------TLGGENCTNGAKVVIHSLEMLLTIMNDRVLQ---EVALKFFRLILYLVEFSPE---------------SLAEMSDQLMSSLCQCIRLGMTGQFGMEITSTSLESLTEVV-NLAFLFKEMLPTVFETCNTCENSIYAESCSALYALIAFERSFFDEYVNELFS--KKSNQQARQVLEAAFTELRRGRVQFRSRMEQFLNKIQG.............................................................................. 924
36 -12.300[U] KOG4224 Armadillo repeat protein VAC8 required for vacuole fusion, inheritance and cytosol-to-vacuole protein targeting  ali follow..  11  16.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YEPLLADREREAVADLLSFLEDRNEVNFYSEEPLRALTILAYSDNLDLQRSAALAFAEITEKDVREVDRETIEPVLFLLQSPDAEIQRAASVALGNLAVNAENKALVV----------------------------KLNGLDLLIRQMMSPHVE-----VQCNAVGCITNLATLDENKSKIAHSGALGPLTRLAKSKDIRVQRNATGALLNMTH---LVSAGTIPVLVSLLPSSDTDVQYYCTTSISNIAVDAVHRKRLAQSEPKLVRSLIQLMDTSSPKVQCQAALALRRYQIEIVQSNALPSLLRLL--------RSSYLPLILASVACIRNISIHPLN--AGFLRPLVDLLSCTENEEIQCHAVSTLRNLAASSERIIEA-IQKLRCLILDAPVSVQSEMTACLAVLALSDYLLNFGICNVLIPLTDSMSIEVQGNSAAALGNLSSNVDD--GIHGYLVRFLSSEDSTFAHIAAWTIVQLLAFIQSSDDIIELLNDI-----VARDANNGEYEDGEGDVILLSGRALHLIEQDT........ 548
37 -12.000[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  8  1....................................................................................................................................................................................................MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASS-DDRRNAVRALKSLSKKYRLEIQAMEHLIHVLQTDRSDSEIIGYALDILYNIISNEEEEEVEENSTRQSEDLGSQFTEIFIKQVTLLLSLLEEFDFHVRWPGVKLLTSLLK---QLGPQVQQIILVSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAFENAFERLLDIISEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKE------GSYIQRMKPWFEV------------------GDENSGWSAQKVTNLHLMLQLVRVLVSPTNPPGATSSCQKAMFQCGLLQQLCTILMATGVPADILTETINTVSEVIRGCQVNQ-----DYFASVNAPSNPPRPAIVVLLMSMV----NERQPFVLRCAVLYCFQCFLYKNQKGQDATGNSVSAGQLLCGGLFSTDSLSNWCAAVALAHALQENATQKEQLLRV--QLATSIGNPPVSLLQQCTNILSQGSKIQTRVGLLMLLCTWLSNCPIAVTANVPFLTGQIAENLGEEEQLVQGLCALLLGISIYFNDNSLESYMKEKLKQLIEKRI----------------KENFIEKLGFISKHEDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQH----------------DNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLL-----KIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELAT----LKSQLNSQSVEITK---------LQTEKQELLQKTEAFAKSVEVQGETETIIATK-TTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEI------TDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEED 938
38 -11.700[O] COG5021 Ubiquitin-protein ligase  ali follow..  8  378..........................LFQILRYIAKTLREATDEI--DEEYNVRFFYLISNLADFAAGLIPTLLEIVKRTLASATHLLETFIDNSET----------------TTEFIENDGFTMLITSVANEIDFTLAHPETWQPPKYSVVYYSISFRELAYIRSLLKLVLKLLSTDIRNLIDSPILVSTLITYTLDVVQKVINSEPVLVEAGLIPYVIDNFPKLIGPSAELLSLLPDVVSAICLNPEGLKQVKE-----------KGLINNLFDFLLDADHARTGGDRSTEYGTDIDELARHYPDLKANIVEALCNVIRKRNEREFLFTSPKDQKYFFHRKNEEILTDKEEHEPASVLFGMSLGNGSFSQVPQHLEARDFLAIIFMENPPYEYFTSAFMDVMKVLNDQLENLNDAILNIVTNVYIDLTTLSCKRIMQIYSYFDKRGFSLIKNLKLLFQKCALEEMYIRQHMPDSVITETMPLPIVDVSGDGPPLQIYIDDPKKGDQKGKITSVKTRNTLQMRTILYTLTTEVHIFENVVENLNFNTFVFTIPKASPNSTEILQTIPAYIFYQKGGYLLYLHIIRDLFTNYIDESNGILTLSCLINALTFYNKSMQTETMENVQSIGK-IMKALTVPIKVMALAMILDLDKS-TQSRNVPYSVFKQLLSMLKNIFTNVNIYTKELYELHWDLIFPPIKKISLFEQVGIPGDVAANYLTDTGDDLPADN-KKLIGEDKSIYYPQPMQAQYYKGCSSKELDELRDTFFNDGLPSRIFTVL------PFYPKLVNAFAKTLLQIFTKYDEPTEVFAGRILDRILETDLDDPATLSSLIHLFGIFLNELMQRFIEYLEKSLKPEHVNTPWFSKALYVYEIILAKSELPHLEELSKDVLLRYPLLSMAKVFRIPDPMKQKLFDILIRVSDISNFYSALATSRILIFYSRDELYANN----ESSFLLLTRRCFETTENVDALIR-LTTILEEKAHVVMRS-LLKLLVELVSSYNQCKFEFLTFSRRNTYAERPRPRTTAIFFLYRLLDKPVGKRREVIGMLARSVILADPHMNFIRKFAIEAIIKLLESNHLKLDMWFRIITSMVYVQAPYLRQLLDSNKVEADQYQLCKLVIDL-----------GLPSVITEAMASIDLNYPFSKKIFNVAVEALN... 1862
39 -11.600[TW] KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins  ali follow..  9  350............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EMTLERAVSMLEADHMPPISAAATFIQHECFQKSEARKRGILKLLQLL-----KVQNEDVQRAVCGALRNLVFEDNDNKLEVAELNGV-PRLLQVLKQTRDLETKQITDHTVNLRSRNGWPGAVAHA----------NPSTLGGQGGRITRSGVRDQPDQHGLLWNLSSNDKLKNLMITEALLTLTENIIKANGLLDFDIFYNVTGCLRNMSSAGADGRKAMRR---------------------------CDGLIDSLVHYVR--------------------------GTIADYQPDDKATENCVCILHNLSYQLEAELPEKYSQNIYIQNRNIQTDNNKSIGCFGSRSRKVKEQYQDVPMPEEKSNPKGVE-----------WLWHSIVIRMYLSLIAK-------SVRNYTQEASLGALQNLTAGSGPMPTSGLQHTRKMLH-VGDPSVKKTAISLLRNLSRNLSLIAKETLPDLVSIITDLLIETTASACYTLNNIIQNSDLLNTGGIQKIMAISAGDANKASKAASVLLYSLWAHTEL............................................................................................ 853
40 -10.500[U] KOG3691 Exocyst complex subunit Sec8  ali follow..  9  13...................................................................................................................................................................................................................................................................TVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTEL------------TTAIRTYQSITERITNSRNKIKQVKENLLSCKMLLHCKRDELRKLWIKHVLNLLDEIENIKQVPQKLEQCMASSATDMLVSAVESLEGPQVEGLSDLRLELHSKKMNLHLVLIDELHRHLYIKSTSRVVQRNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELDPEENSTLFMGILIKGLAKLKKIPETVKAIIERLEQELKQIVKRSTTQVADSGYQRGENVTVELLELLELLFDKDMADVWVKIQDVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHAISMSAYLREQRRELYSRSGELQGGPDDNLIEGGGTKFVCKPGARNITVIFHPLLRFI-QEIEHALGLGPAKQCPLREFLTVYIKNIFL-------------------NQVLAEINKEIEGVTKTSDPLKILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAYSD-----------QFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKES------------EVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFSNLSTSQMLSPAQD-PPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEESMDYDPLVVKLNKDISAIEEAMSASFQYIFEGLGHLISCI------LINGAQYFRRISESGIKKMCRNIF-----------VLQQNLTNITMSREADLDFARQY-YEMLYNTADELLNLVVDQGVKYTELE 924
41 -10.500[T] KOG4500 Rho/Rac GTPase guanine nucleotide exchange factor smgGDS/Vimar  ali follow..  12  41............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HELAECFLGLTKCDDTNVRKEAAKCIAEITK----TKRNIIAAFLECLRQVPTSDGSMELPIQICRALGNICYLNDEARDLILELEGD-AVLLRLLDITTIEDVANAAQFIKVRGAKRAMELGVMKKLQGIIDIGASNVEQHEDLLLNTLPLLSILTENVSDLNQLSRILAASTNPDLAEMCLELLHYQAESDEVKLILAKDGLCETIYNLLEKYKTLASTSEARALMKLACELIVLILTG-----------DDSMHYLYT---------TPLLKNMVDWL--------------DSTDIDLLTTGVLALGNFARTDSHCIYFVEQQTMNKLLEVLAKNNGVKDDVRLQHALLS------------------ALRNLVIPKPNKNAVIQAGLVQTILPML--------EIHQPPVVFKLLGTLRMTVDGQEKLALE-IEQLVHWSKSSDYAGVTGESLRLMAWLI----------SKIAYALPRKGDAPAEQIADKIPLTQDYDRFLANEGTVEAMVSMLTAQHLVMQNEALIALCILSVVYL-------------------SQPSEAAQAQLLQDELVKCEVGKKLAE-LISKSSDTMTKEIVENLQNCVNLLKSSEQLVAHLEQHNISIPILTE 630
42 -10.400[DK] COG5103 Cell division control protein, negative regulator of transcription  ali follow..  9  258.......SMKEAILKKYPPGTATETDVAYLINSLVAIHDYGAWDTVLMGKAIVSSFENLNWEAMLSMFDNPKFMITGTPSLVLFFTIFTNAYKLRQTNFTLDFLWVLWRNPLPQLSIISHIILSPTSREFNVNPVVSVDSLKDYSEELVNYAKIYEKSNLNC---ELVQILLRLLSEVSLFLNFLDEKVESLAFQWCSDFFSNFKEHKFVFVRIERTNPQFLFAFLRSLWLKDSSSVNQVVEFIIENDFTSHIG---IAALAAARKALSFQDWLDKKMLEFEDADGLNVFLVEVLDFLMEQKEESVVLSIDTVNVLLTTLMDNSPDVESEVESYFQALYERRISIGKIKKSENPRDLDLFACLQHSLFDEYRFFPALTAVLFGSLIQFELLSFVPLGVALRYVYQALLMTDSKMFRFGMQALVQFILGIPSLQLVRPDIYDSIREMIASNENTEVEKDKLDSFSALANPASPKAPEYTFVSIHVPPLNVPNAEGEIEESVCDNILFAINNLSQLNFNEKLKDVKDNLTIVTQRVSREANFLSLYGKFLEELKSSDRDTLQAILDIMNNNAETLSPSEKTNLKNLITLLRNKPITTLQVSFKDLLLEGID------------SGRIDRVLPFVCKVLEKASSSVLMGILKLLVELYQFADFRLNLIELLLNNLNVKMDNIEPSEMYRNHLVQKADLEKELPEDV-ITQLIIQQSVLEIISAVVRRSVGIAAITTKSSNPSRLLLAARQM--AKTLAGNLAMVTCREPLQMLMINNFRTIALQDVENVH--AAVAQAIDEL--VSQNLFVASSVIIDAEIEHMIVERVRHRKTTPNLPFVDPAGAANLHLNLELTPQQFQLYENFDRLSLSTIMSNNSFTSLNGLRTDSADSTDALNSNLNNTVENEANQTALNYARNLLIIIGQLFQLAAQMPYTSMQEV------PADHELHELVNQFLTGVASINHPIADHVFLLCAQECCRILLTDSKSPFILEVFSAILEYICQASTKTAINVSLYWNFSNDL----EKLNLPIILSLIRFGILTSGEVDYHVARGVRSESGPVTDFAIELLRTAVGGENPMALPFVNSITSLYEISESFSGETKQAYEQLVETMNK........................................................ 1565
43 -10.300[T] COG5635 Predicted NTPase (NACHT family)  ali follow..  7  181FAIYELPLRRIDVINAVEAEGFSSDDFLKAINQ-IVPLAIKPISLGFLLNTYRR--------HNSQFPPEQKRYESYLEGCKCLCEE-----VSKCRHALKETGNLDIDQRLIVAARIAAVTIFANRFAVWIDVEQGQVPAEDVPRQKLCFGYEESNGREFEITQEVIQEVLD------TGLFSSR--GLHRMGWAHQTYAEFFAAWYLTQRNIDLSKIKTLL---YSSADSTPKLIPQLHETAVWLASMRDNVFQEIIKTTDSELRATIVANLLMQYEEEKLFDRGFCNVRNYAKL-SGLAEQLKVYICD---------SSKKEDTRRIAIDIA----------------IECNLSELQGDLAKLTLCPSISIRVNAARAISSIGDQSTR-----LKLKSLALNVLEDEQDELKAYALKALEELFQESELVPQLDSEDLVIALDWLKTQGVRCFGHPFEELGDAILLKAWEHVNVPGVLEGFTQVALLQWKEHQKLISHSPSLQAQFQESLLGNNQKRYALIENLVESIAEKDEDEDFYFLTSSMTEPIISSNDVDWMLEKLQ------DSNHEKIQRAWAKIIEEVFDRRDTKNNSILSDVFSYYFTPIELDSEEVTQLRDHYLK-KERVIDCLEQLESGDLSAWWRLNREMT-EQATKKRIIQGAIQYIQQQTNIDYS---------IGTNTYNFSELYGCKALQLILTEAPRTLDNPRKNCRKLVSLSYHHSPDEFLTTLLKLIDKENQDNNIFVIDRLEMCWDEKLENNLTEKVKDSQLKPN---VFRKLLEKLIEQGA------VQAKDIALSTIRNYTNSEFDSERQKALFAIKALPDSWNVIWEKITADVQFGREAFELAASCNLSGIKFDLTEKQIADWQYPHYEDPDHRNEVMAYIVSPRDNIAFFRNNSLSQLRDKGTIEACAELERLIQEL--------PHLPWLKETLTYAQQNMRRETWRPFKPDKLLEFLIIPEPSNLDLS-LSTIDKRTEKMTSGVTSNNVTCSSPEKQKRFNWEILFGVIGIIGVIA--TVVGI--GIFNDVLKDS---NGSPSKIEQQAMPKN............................................................................................... 1319
44 -10.200[IG] KOG1340 Prosaposin  ali follow..  7  5...............................................................GLLAVLALCCAFGVFAAATPLLGSSKCTWGPSY----------------------WCGNFSNSKECRATRHCIQTVWETQKVPVDTDSI------------KDMVTQARDQLK--------SNQTEEELKEVFEGSCKLIPIKPIQKECIKVADDFLPELVEALASQMNPDQVCSVA-GTVQNEDDSSEETELAMQPNQLSCGNCNLLSRLMHSKFAATDRDDMVETMLHMCGSLSSFSDACANIVLTYFNDIYDHVSKHLTTDAVCHVSGVCASRYHQHEEEKQPQEALVALEQLVKHLRDVLVANTT--ETEFKQVMEGFCK-----------QSKGFKDECLSIVDQYYHVIYETLVSKLDANGACCMIGI-------NSASSMKDVPIMPLLPVIEPAQVKITIEKLEKHEKKQLGASEPKFSQQEILDMQLPIDHLMGAANPGALVEGGELCTLCEYMLHFIQETLA-DDEIKHTVENICAKLPSGVAGQCRNFVEMYDVCPLMQMCPKNLPKKEDVEVFNPQPASDEQDPPTCPLCLFAVEQAQMKIRDNKSKDNIKKVLNGLCSHLPN-------EIKEECVDFVNT--YSNELIDML--------------------------ITDFKPQEICVQLKLCPKTTYALWDLRISLEDDVDGEDKSSSEEISFNDIESLEELPPQLAFDPGFTA------EELVKTLEKRMGKHPTRDSIKHILEESCDRM----KPMNTKCHKVIDKYGDKIADLLLK---------EMDPKLICTELGMCILADLDDLE--VDEALKYDVIALPRQDNKLSSSIKEPPTCVLCEFIMTKLDADLKNKTEQDDIKRAIEAVCNATVRKQCDTFVDGYASAVLKLLSDVPPKQVCQKLQLCFSVAVTDEVLECGVCHGVTQALLPFLREKKDNVSEVTALQMTSVGCENLPEMISIYGSSIKN-------------------LAKRPYIDQSHICAEIGKCFESEKSSLA............................................................................................................ 947
45 -10.200[O] KOG4413 26S proteasome regulatory complex, subunit PSMD5  ali follow..  12  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MEDVNQLFDAAFEFAHYPGAQNETSVKEFLDRFPLPVIFNALQTDPDPGFENTLVTCLERLF---ASLIPQYMPVLQVGLKADSAVVKSLACKTVLCLLEDQLVVNNGIYPLLLDYIINSDDEVANAASETIKSLARFPDAMSVIFPSLRNLAARCSSLARVRVLSLIVKLFSISRL--KKSGLLDLLEAEMKGTKDTLVILNVLELYYELMEVEHSSEFVPQTSL....... 248
46 -10.200[ODR] KOG4151 Myosin assembly protein/sexual cycle protein and related proteins  ali follow..  9  360..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PVSAETRQHVAICLQRLEEDMVFDTKRTIFKEKVDMFFNALISRCTNDDEGHKYRI------------CFLITMLQGPVDIGINLITNDQLTPIMLEMAASQDHLMQGIAAELIVATVSKHERAINMLKVGIPVLRALYDSEDPTVKVRALVGLCKIGAAGGDDISK-------------------ATMKEEAVISLAKTCKKFLLETEKYSVDIRRYACEGLSYLSL------DADVKEWIVDDSLLLKALVLLA-KKAGALCVYTLATIYANLSNAFEKPKVDEEMVKLAQFAKHHVPETHPKDTEEYVEKRVRALVEEGAVPACVAVSKTESKNALELIARSLLAFAEYEDKEASGEGKIKAGHAIAKLGAKPGQRAYEVVKPLCDLLHPDVEGKANYDSLLTLTNLA----SVSDSIRGRILKWFMTDHEHLRAAAAELLLNLLFFEKFRLK-----VLYSAEVEEERLSRASAAGFAILTEDENACARIMDE------------IKSWPEVFKDIAMHEDAETQRRGLIANIMHSSNKLCSEIVSSEVFRVLVAV--ERAGSTEQAKRGLEAAEK.. 938
47 -10.100[JK] KOG2038 CAATT-binding transcription factor/60S ribosomal subunit biogenesis protein  ali follow..  11  17.............RPEEAVEDPDEEDEDNTSEAENGFSLEEVLRLGGTKQDYLMLATLDENEEVIDGGKKGAIDDLQQGELEAFIQNLNLAKYTKASLIEEDEPAEKENSSKKE---------NNKNTAESQRTSVNKVKNKNRPEPHSDENGSTTPKVKKDKQNIFEFFERQTLLLRPGGKWSLKPQPQDVVSKYKTLAQKLYQHEINLFK---------------SKTNSQKGASSTWMKAIVSSGTLGDRMAAMILLIQDD----------LQFVETLVNLVKKKGSKQQCLMALDTFKELLITDLLPDNRKLRI-FSQRPFDKLEQLSSGNKDSRDRRLILWYFEHQLKHLVAEFVQVLETLSHDTLVTTKTRALTVAHELLCNKP---EEEKALLVQVVNKLGDPQNRIATKASHLLETLLCKHPNMKGVVSGEVERLLFRSNISSKAQYYAIC--------------------------NQMALSHEESELANKLITVYFCFFRTCVKKKDVESKMLSALLTGVNRAYPYSDKVREQIDTLFKVLHIVNFNTSVQALMLLFQVMNSQQTISDRYYTALYRKMLDPGLMTCSKQAM------FLNLVYKSLKADIVLRRVKAFVKGLLQVTCQQMPPFICGALYLVSEILKAK...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 616
48 -9.840[R] KOG0567 HEAT repeat-containing protein  ali follow..  13  39...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AIEAISKAFDDDSALLKHELAYCLGQM--------AQALDILTKVLDTTQEPMVRHEAAEAMGAI--------PDVLPILEEYKQDPVVEVAETCAIALDRVRWLQSGQ-DKSVTELKAIYLDAQQSDRYRAMFSLRNLRTE---------ESVLAIAEGLKDSSALFRHEVAFVLGQLQEPCSIPFLQENLEDR---LENEMVRHECAEALGAIATEDQILNRYAEDD........ 266
49 -9.780[R] COG5307 SEC7 domain proteins  ali follow..  9  144.....LIKCIEQLIQIKVCM--KNEKMKNLMEQLKPLLQTECQ--FDKFLIVELFQYCFESSQD-------EVMNISLDTISKLAS---AYFSSKDKTPASFGPPKS----------LLQCMVDMVCDSINDEVVDGNL---------------------------QLNVVKALSAFILCSEQDSMLHGAILLNSVRKLFNVFLLGDSDTIQSVAQASLTQAVTVVYERLRASHTQSNSTSALPEEDASVTENWVHDEDEPDKKITLHSMASAVFRSMCRLAVRQTSPDKVSNIRSQAMRAKLISLHLIYRILEKLSRNAVSPVPQVFEVCCDIFYLMV------FSLRAHFKQEIEVFFREVYFPMLDLKN--KLHTLLIIQRICLNPRALVELYTNVFEQLLFSISKVTRSSTPFLNTNSASLKSEVVQLTTFSDFQLKLKTLQCVLDILQSLSNWAESGLYLSRRGVSTDEQGFVGDYDALSRSDTPVTNPYYNGKQSFEANSHSSSSIALADPSQFESNKQRKKLLRTCINFNYKPTRGLKMLSEYVDINDPKAIISVMHEFIDCLSFINLKFVDALRRLLQ-----RLPGEAQKI-DRIMLKFSERYMKENPSAANADTAYILAYSIILLLHSPRIKNKMTKEDFIKNINDGADLDEDYLGFVYDDILKNE----------IAMKDDQELAAIAPLMNNFSTSSGFTTFTSNGRDLQRVACIQASEEMANKATSVLKKLLYQQKHGSQKTNNATHFEHIGPMLEATWMPILAALSNPLQNSDYVNELNMCLDGFFDLDLIRDAFIKTLTNMVIKTLLRIASTEGNNLKDSWKDILTIISQLVQLIGVGVDETEVPDVINARVRRKNVNIGSSNSIRHVSGSTSRSTRTRSLSKPLSPEAVSELMSTEVVLSIDRIFTQTSSLSGSAIVSFFKALCE--VSWDEITSSSDLEQPRLYSLQKLVEISYYNMQRVLGRFFNMVGSDENRHVAVFALDSLRQLSMHFLEIEE--KPFEYVMASDTVVEVKELVLQCVKQMIQAKISKIKS-FGVFTFAAKARSEILISMTFDTLVNLFSE............................................................................................... 1335
50 -9.600[S] KOG4346 Uncharacterized conserved protein  ali follow..  9  3.....................................................................................................................................................................SLPAQVANRLGRRLPETFAP----VSYQKLLLRQWLKSLHFVLQCDDNREYFDL-EPYSWLLSQ-----------AINLIYDVSTLESLLRVLKDYAVAPRGRKVVHTILKELDPAACLKTAQSALSAGLNLYVLIGA-----ATLETPHWKHCLLQKLPLQRTPVDNKQLITLASYLNAVA-PAQLQVLLNQLLGILQKLGSQEHLAISKLLVLAAKCLCGNLVMDLNIQRQLHDGLSNHLQSPDALQRHVGMELIFNFIALPDAKEDDRLRFEYDSFKDTFHWHIFEEFDELGQFESPSKTKLDEKPCEDQLKQLELHLSDFMSTTEQKEPHKPNIEIQANPAPENQNVNMQLDSDDDEPLDEDDD----ELKPYDMSNDTTTTIDQRPKFVIDLLHLL-------------------------REKVENYQVFEGALGTAEQL-IRGQLAKHDTQLALDLLQLFLVMEMQFYYEQFERT----------------------------------------------------QFKCCVAI----------------------------------------------------------------------------------------------CVAHPGPCAEYLCRQFHT-----------------DNSFYSASVRILILQVLAATAKELSGDENMQNEMEIVDVIPPAAKHPRKFEFQQEEESPAARLAAAQRIIRDRLRAKTKRYFSKPKAGDQMEKANPFHPFFSLVRGQRTRQMLYVDTQLLVNLLNTMSVLVMCSPAMTREIFDLCAF-VRFNAEARVRAATLQLIGIALVTTPA-LQRWLNDFIRSPGETSEECRELAQSILDTC--YKLFD................................................................................................................................ 711
51 -9.580[JU] KOG2153 Protein involved in the nuclear export of pre-ribosomes  ali follow..  9  228..............................................................................................................................................................................................................KRRELMQEFKDTIASHANMLLSNPQVNIVRLRDLYNLCNGEKIHSLVRESVQKLAI---STLQVLLDIIREQTAEEKAQKQKKETRNLVNYEESLLRY--LKYLQLCEKLSN-ESTFTFKMGILSVKALARIVVSAPH---------NYSTNIVSSLVRLSLAKNETVIREVCEAIRTVFK--------------------EDIHLKITLFTARSISTLVTKR------KGRVPPELLRTLLSMNITEVKDEDKKSGKDALIAKKYQIKKEKASKTAKKYKKQLARLEADLLEVEAEESMSKKLKNATEAMKFAFQSYFSILKRMPNSALLEPVLEGLSKFAHLLSIEFYEDIVSTMENMVQNENLKSLDQLHCINTVFVIL-----SGDGQLLNIDPSKFYRLAYLVIRRKAVPLSRVAAFVKRLLSIATVLDDFPALCIVSLVRSLFIAHPKLSSMIE.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 688
52 -9.580[O] COG5110 26S proteasome regulatory complex component  ali follow..  9  8..............................................................................................................................KQQTIDEQSQISPEKQTPNKKDKKKEEEEQLSEEDAKLKTDLELLVERLK----------------------------------DDSSLYEASLNALKESIKNSTSSMTAVPKPLKFLRPTYPDLCSIYDKWTDPNLKSSLADVLSILAMTYSENGKHDSLRYRLLSDVSDFEGWGHEYIRHLALEIGEVYNDQVEKDAEDETSSDGSKSDGSAATSGFEFSKEDTLRLCLDIVPYFLKHNGEEDAVLEIESIDKLPQFVDENT-----FQRVCQYMVACVPLLPPPEDVAFLKTAYSILSQNELTDAIALAVRLGEEDMIRSVFDATSDPVMHKQLAYILAAQKTSFEYEGVQDIIGNGKLSEHFLYLAKELNLTGPKVPEDIYKSHLDNSKSVFSSAGLD--------SAQQNLASSFVNGFLNLGYCNDIVDNDNWVYKTKGDGMTSAVASI-----SIYQWNL------------DGLQQLDKYLYVDEPEVKAGALLGIGISASGVHDGEVEPALLLLQDYVTNPDTKISSAAILGLGIAFAGSKNDEVLGLLLPIAASTDLPIETAAMASLALAHVFVGTCNGDITTSIMDNFLER---TAIELKTDWVRFLALALGIL------------YMGQGEQVDDVLETISAIEHPMTSAIEVL--VGSCAYTGTGDVLLI-QDLLHRLTPK-----NVKGEEDADEEETAEGQTNSISDFLGEQVNEPTKNEEAEIEVDEMEVDAEGEEVEVKAEITEKKNGESLEGEEIKSEEKKGKSSDKDATTDGKNDDEEEEKEAGIV----------------------DELAYAVLGIA-LIALGEDIGKEMSLRHFGHLMHYGNEHIRRMVPLAMGIVSVSDPQM--KVFDTLTRFSHDADLEVSMNSIFAMGLCGATNNARLAQLLRQLAS--REQDALFITRLAQGLLHLGKGTMTM-VTLASILTTAVGLVSPSFMLKHHQLFYMLNAGIRPKFILALVGQAVETVGQAGRPKKITGWITQSTPVLLNHGERAELETDEYISYT... 974
53 -9.390[R] KOG2226 Proteins containing regions of low-complexity  ali follow..  8  1.....................MGSQQSKLDFRNAVLRLHEERN-IPKFDLIWERLWTLPETTEDVFHKVKDNAPENLQTIIAVLWDKLEDLQKETLFDDPAAPTTKCALNCMRLLTRLMPIIFEDKSMLEWFDYFAWTVPKDPNIPAHNDLTHGVHYCIWELHRVEVLRLLLSLFS---EEIYRTDGNGSSCCAYVASLLSSLINTDNSVAHMSLIEYCFSVLLILMS-EENNNGTPCYNNYRSSKNTLPKNYFSILLSKLQPYSDFQIILDGMSRLLYPKRSSLIMFDYYPLVLIFCKLFIHYNERFF---IFLLYLSFEYLGDPSTYNHLKLCVILLKRLTAEKYFCKRLNKPFQQSLCYLCLYAQNLNSHSSQSLFELFQSASYPGLISNDVNHKILKYVIGAINNAIQYAQKYNAPLLYFFSMHKDYIEAVSALSFDAIMSVRNSSAEGDSAYWTRNGKTFSSKAFDSILLSRLRYVRSKSPTPYYPIESSEFGFTNLKDVTSKDEITDGFDKALRSNSLRTHRDSRPVQPLLKQRPQLHRALTESATLHGNDRSLEDTD----------EAKVEPIAHSVDYTFKPTVEWWNKWWPSLNFRTMLDIFTDLSLKISDMKKAGHPASEIMAMIKTQKYPATNQPYIPYRTKEWRQQLANFARLFAWQVS........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 772
54 -9.150[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  11  433...........................................................................................................................................................................................................................................................................DVLGETLVAEAYCKTWSYRED-ALLALSKKLMEMKEDLKNTLRASVFLVRRAIKDIVTSVFQASLKLLKMIITQYIPKHKLSKLEAHCVERTIPVLLTRTGDSSARLRVTAANFIQEMALFKEVKSLQIDNVMKFSVSALEHRVYEVRETAVRIILDMYRQPPDDSNTRRNILYKTIFEGFAKIDGRATDAEMRARRKAATEEAEKQKKEEIKALQGQLAALKEIQAEVQEKESDAVKPKNQDIQGGKAAPAEALGIPDEHYLDNLCIFCGERSESFLMLTRCDHCKQVVEISSLTEHLLT................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 801
55 -9.060[A] KOG1104 Nuclear cap-binding complex, subunit NCBP1/CBP80  ali follow..  9  20.......................................................................................................................................................................................................................................................................................KRRRVSENQEIEDRLESLILRVGERSTSSVESNLEGLVSVLEADLGTFRLKILRILSDCAVRMLLNAKNYKFGGEFVDHMVKTFKESLKMCRWDAARYSLRFLADLVNCHVISATSLLQLLDTMIDVSNEDTVP-QVRRDWFVFAVLSTLPWVGRDLYEKKESALESLLLRIEVYLNKRSKKHHNALRVWSSDAPHPQEEYLDCLWAQIRKLRQDNWAEKHIPRPYLVFDSILCEALQHNLPTINFEYPMPWVVYRMFDYTDCPDGPNLPGAHSIERFLIEEHLHHIIETYHHERKDCAAQLLSF--------PYKHKIPLEYCIVEVVFAELFHMPTPRYLDICYGSILIELCKLQPAT-----QVLAQATEILFMRDSMNTSCFDRFWDEWDSCLLLDGEHPRPKFIQEVLQKCLRLSYHQRILVVAIRQKCTPEEVVNILKDIPNSGYSGEEMSDGSFNALKIDVFVQTLLNLGSKSFSHSF-----AAISKFHSVFRALAETEE---AQICILHNIFELWSSHQQMMVVLIDKLLKLQIVDCSAVATWIFSKEMTGEFTKLYLWEILHLTIKKMNKHVIKLNTELSEAKEKLAKADSSSSDSEDDSSHKRKKPITHADKPSEEVVERMEEKLEAANVNQKRLFL---IVFQRFIMILSEHLLRSDTDGRDPDTDWYRWTIGRL----QQVFLMHHEQVQKYSSTLETLLFTSDLDTHILEVFQQFVAL..................................................................................................................................................................... 798
56 -9.050[U] COG5064 Karyopherin (importin) alpha  ali follow..  8  23.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ELRRQREEQQIEIRKQKREESLNKRRNLNAVLQNDIDVEEEADQSQVQMEQQMKDEFPKLTADVMSDDIELQLGAVTKFRKYLSKETHPPIDQV---IACGVVDRFVQFLESEHHL-----LQFEAAWALTNIASGTTDQTRIVVDSGAVPRFIQLLSSPEKD---------VREQVVWALGNIAGDSSACRDYVLGNGVLQPLLNILQSSASDVSMLR-----------------------NATWTLSNLCRGKNPPPNWSTISVAVPILAKLLYSE----DVEIIVDACWAISYLSDGPNEKIGA-APRLVELLS-SPSVNIQTPALRSVGNIVTGTDAQTQ--LNAFPSLLSHQKENIRKEACWTISNITAGQAIIESNLIPPLVHLLSYADYKTKKEACWAISNATSGGLG-QGVIKPLCDMLNGSDNKIIQVALDAIENILKVGEMNQYAVYVEEDMIHDLQSSGNNDIYLKAYSIIEKYFSDEDAVEDLAPET........ 513
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.