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Query: [J] COG5099 RNA-binding protein of the Puf family, translational repressor, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDKSKQMNINNLSNIPEVIDPGITIPIYEEEYENNGESNSQLQQQPQKLGSYRSRAGKFSNTLSNLLPSISAKLHHSKKNSHGKNGAEFSSSNNSSQSTVASKTPRASPSRSKMMESSIDGVTMDRPGSLTPPQDMEKLVHFPDSSNNFLIPAPRGSSDSFNLPHQISRTRNNTMSSQITSISSIAPKPRTSSGIWSSNASANDPMQQHLLQQLQPTTSNNTTNSNTLNDYSTKTAYFDNMVSTSGSQMADNKMNTNNLAIPNSVWSNTRQRSQSNASSIYTDAPLYEQPARASISSHYTIPTQESPLIADEIDPQSINWVTMDPTVPSINQISNLLPTNTISISNVFPLQHQQPQLNNAINLTSTSLATLCSKYGEVISARTLRNLNMALVEFSSVESAVKALDSLQGKEVSMIGAPSKISFAKILPMHQQPPQFLLNSQGLPLGLENNNLQPQPLLQEQLFNGAVTFQQQGNVSIPVFNQQSQQSQHQNHSSGSAGFSNVLHGYNNNNSMHGNNNNSANEKEQCPFPLPPPNVNEKEDLLREIIELFEANSDEYQINSLIKKSLNHKGTSDTQNFGPLPEPLSGREFDPPKLRELRKSIDSNAFSDLEIEQLAIAMLDELPELSSDYLGNTIVQKLFEHSSDIIKDIMLRKTSKYLTSMGVHKNGTWACQKMITMAHTPRQIMQVTQGVKDYCTPLINDQFGNYVIQCVLKFGFPWNQFIFESIIANFWVIVQNRYGARAVRACLEAHDIVTPEQSIVLSAMIVTYAEYLSTNSNGALLVTWFLDTSVLPNRHSILAPRLTKRIVELCGHRLASLTILKVLNYRGDDNARKIILDSLFGNVNAHDSSPPKELTKLLCETNYGPTFVHKVLAMPLLEDDLRAHIIKQVRKVLTDSTQIQPSRRLLEEVGLASPSSTHNKTKQQQQQHHNSSISHMFATPDTSGQHMRGLSVSSVKSGGSKHTTMNTTTTNGSSASTLSPGQPLNANSNSSMGYFSYPGVFPVSGFSGNASNGYAMNNDDLSSQFDMLNFNNGTRLSLPQLSLTNHNNTTMELVNNVGSSQPHTNNNNNNNNTNYNDDNTVFETLTLHSANLast
1 -127.000[J] COG5099 RNA-binding protein of the Puf family, translational repressor  ali  100  1MDKSKQMNINNLSNIPEVIDPGITIPIYEEEYENNGESNSQLQQQPQKLGSYRSRAGKFSNTLSNLLPSISAKLHHSKKNSHGKNGAEFSSSNNSSQSTVASKTPRASPSRSKMMESSIDGVTMDRPGSLTPPQDMEKLVHFPDSSNNFLIPAPRGSSDSFNLPHQISRTRNNTMSSQITSISSIAPKPRTSSGIWSSNASANDPMQQHLLQQLQPTTSNNTTNSNTLNDYSTKTAYFDNMVSTSGSQMADNKMNTNNLAIPNSVWSNTRQRSQSNASSIYTDAPLYEQPARASISSHYTIPTQESPLIADEIDPQSINWVTMDPTVPSINQISNLLPTNTISISNVFPLQHQQPQLNNAINLTSTSLATLCSKYGEVISARTLRNLNMALVEFSSVESAVKALDSLQGKEVSMIGAPSKISFAKILPMHQQPPQFLLNSQGLPLGLENNNLQPQPLLQEQLFNGAVTFQQQGNVSIPVFNQQSQQSQHQNHSSGSAGFSNVLHGYNNNNSMHGNNNNSANEKEQCPFPLPPPNVNEKEDLLREIIELFEANSDEYQINSLIKKSLNHKGTSDTQNFGPLPEPLSGREFDPPKLRELRKSIDSNAFSDLEIEQLAIAMLDELPELSSDYLGNTIVQKLFEHSSDIIKDIMLRKTSKYLTSMGVHKNGTWACQKMITMAHTPRQIMQVTQGVKDYCTPLINDQFGNYVIQCVLKFGFPWNQFIFESIIANFWVIVQNRYGARAVRACLEAHDIVTPEQSIVLSAMIVTYAEYLSTNSNGALLVTWFLDTSVLPNRHSILAPRLTKRIVELCGHRLASLTILKVLNYRGDDNARKIILDSLFGNVNAHDSSPPKELTKLLCETNYGPTFVHKVLAMPLLEDDLRAHIIKQVRKVLTDSTQIQPSRRLLEEVGLASPSSTHNKTKQQQQQHHNSSISHMFATPDTSGQHMRGLSVSSVKSGGSKHTTMNTTTTNGSSASTLSPGQPLNANSNSSMGYFSYPGVFPVSGFSGNASNGYAMNNDDLSSQFDMLNFNNGTRLSLPQLSLTNHNNTTMELVNNVGSSQPHTNNNNNNNNTNYNDDNTVFETLTLHSAN 1091
2 -54.200[J] KOG2049 Translational repressor MPT5/PUF4 and related RNA-binding proteins (Puf superfamily)  ali follow..  24  239........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KSNNDLVSMVEIYGSVNLMAKDQIGCRVLQKLVEEG--TFHEAKVILLAIIDHVVELSMDPFGNYIVQKLFDVSDEEQRTLIVSVLTSNLIRICLNTYGTRVVQKMIETVKTKQQIALVKSGLKPGFLALVKDLNGNHVIQSCLQLGPNDNEFVLEAATKYCAEIAIHRHGCCVLQCCISN---SVGLQRERLVAEISRNSLHLSQDPFGNYVVQYLIDQQVSAVK---LLVQFRMHYAELATQKFSSHVIEKCLRKY--PESRAEIVRELLCVPN----------FEYLLQDPYANYVIQTALS--VTKGPVRAKLVAKVYRYG-KLHSSPYCKKIFSKTIL.................................................................................................................................................................................... 562
3 -30.400[J] KOG2050 Puf family RNA-binding protein  ali follow..  9  6........................................................................................................................................................................................................................................................................................................................................................................................................................................RKESTEVKKKDGSMNKRVKVAKLPKKVDSFSPKKKKNTTSSGSSESDSMSQNDKKKDSSLNESEDEDFAGFGESASENDELESAESEAENDEESSSQKSNSKESHAQRKKLQKERKAMKPFADTSLKAKSLWDKLRQKTSIKAEERKTIIAELDLIRTNVKQLVFKHDMSRVVQTCVKFG--SKQQRETICAELAGSYVDLCKSPYGKYLAIKIFKYGTPKMKEVILGEMYGNVVKMIRHREAAYVVEDAFREFTNLQQQRALICEFYGPEFQVFKDRTQDIHIDKLLIDHPEKRPSIMQNLWKTIEGIAKGSIGFTMVHRAMEFINHADSNEAKELLNLTKELIYEFVHTRDGSQVAMKLFALANAKDR-KVMLKSLRPYLIETAKDSYGHLVVVAALDCTDDTITGKLLQAEFEGE------------LLKLSADKFARRILLYVLVGW-LKATIGPLLISLISKAAGDMIAESLASQVLVDALLYAPCEKEEAVDA........................................................................................................................................................................ 527
4 -26.400[J] KOG2188 Predicted RNA-binding protein, contains Pumilio domains  ali follow..  9  91..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DSIYREVQGKELIVCNNVFGSKVLEKLFPLSTSRQIKSFSALNGHYVELIQTTFGSYAFEKLLSHMATAETLLMYMYNEIRPEVSMLMSHKLAVHVLGKIFLLLDPQFAYSIIDSATPELRAYCVDKYASQIMRAFIRIDFERSKKRLVSKLLLPFMETLLKDETGSRILEVIVENMSASHLRFYAVFEGRFYRLCVHPIANFIMQRYIRR---LGRKEIGSVIDELKKNTDNIIRKSFLP-VLRTLLEKSHLHCYQDDIFSMIQTSVRKLVNNLLGAQLLEEMLHC--EKQHIQLLLDSVL--------DLSKEQILEYCLETVSSHLIEGILDLSDLNPVFLKKFLNILSGSFATLAVSAPGSHIVDKAWKATRALYRTRIVRELAEGGDDVKFDFYGK........................................................................................................................................................ 582
5 -8.340[R] KOG3518 Putative guanine nucleotide exchange factor  ali follow..  8  3..........................................AAQAHQHCSTSVAGDRLLGSSTELAPSLLGIYDTLTNSFAAGGVAAAPTATSHESKASSSGDSTPKRSNSNCSSSSSTGSSTGSCSSVPTSDDQSASYTLASSSTHLGHQEPPAPLVVAGLRDEPDGAQLSRLVQRRSQESQIHGSSSSIASSGSSRRGSNIRILSPNVHRIITHSDIQPVEAVSAEALKQHQQQSQRSPTQGRYIKTGHSGTPPAAGSAPKLKLSHIPLSKITGKLSTQSGSELVSTFDSSNEYLNSVAFAAF--EKSKPQDEDRTPTNKSVPGTPFHFDGHPFQGRKLTLPRYDSQQSIKLIEMEQLAATSAQLLHAKPATPGTPATPTPSATKAKEFVCSEPLSPVDIVDTINFDLVAQHMERLTLADPGDLDPRAELIEAVNKTLVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLE------KTCLEIVDSERSFVEDLGQVIKGYLQDWKELRVDEFAN--IEEIYEF----NSMLLLINTGRDPGRI-----ARCFIDL-TTYCTSYPEAISLLTKLLTHTYSLLAS------TQKLLQHRLPLGSYLLKPV-----RIL--KY---LLDSLRKHCDVKEVVEAHVIMRQVAHNIDQVKRTVLGELRQEGLLMEQHNKQRLVLLFATML-----ITKQKEDGRLQFK----------TYISQNNL--MLSEHLPGEPTSFYVIPFDEPRHQIKLT------ARNRDQKRIWTQHIKGVM--LEKLDIPMRAKELVYQLGNEEGEC............................................................................................................................................................................ 863
6 -7.820[S] COG5543 Uncharacterized conserved protein  ali follow..  10  604..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TYIFQSLSPTIVKNDNESWKNIVMELIKASET---WGLIKDVLCDDSLEDTPAQLILSRSLKETSSLL-----TVLLTKCLSLFDEEFTPFTLNYYGELMMTLWEIRHGAEYCSFLFECNKHEISLHKNLSVIQEKSSFITRRSGG-LSITAILVAGKDKREQLIEQTVISLISIAKQPHAMNTLKTIFTEHRLSSV------SVEYLEPAIALSIEGFSH---LWPIRNCSV-----MLFTALINRAFGLSTKMFFSKYLLRELEVSVASLSSNNMFSRLQYAQPYGNENEWTGLSQFE--------LIFKCTASRIC--KVREIASLSLTCLLDCSKMTTFIVSQLKGVAGLQQNEIHGKLLT........................................................................................................................................................................ 1024
7 -7.770[U] KOG1077 Vesicle coat complex AP-2, alpha subunit  ali follow..  12  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MRGLAVFISDIRNCKSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLF-DFGHMEAVNLLSSNKYSEKQIGYLFISVLSDLIRLIIQSIRNPVHVNLLQCIANIGSRDMAESFSNEIPKLLVSGDTMDVVKQLLRLFRSSPDI-IPGGEWTSRIIHLLNDQHMGVVIDALVKRNPDEYKGCVNLAVSRLSRIVTASYTD--LLRLLVTEEAGVRARLNETLETILNKAQEPPKSKKKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRLALESMCHLATSEFSKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEMLNLETADYSIREEMVLKVAILAEKYADYTWYVDVILNLIRIAGDYVSEEVWYRV...................................................................................................................................................................... 457
8 -7.540[T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac GTPases  ali follow..  10  236...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VLNELVQTEKDYVKDLGIVVEGFMKRIKGVPED-FGN--IHQIYDW----HKDFFLAELLAQLFIKHERKLHIYVW-----YCQNKPRSEYIVAEYDAYFEEVKQETLSDFLIQRITKY-----QLLLKDFLRYS---EKAGLECSDIEKAVELMCLVPKRCNDMMLGRLQGFEGTL--TAQGKLLQQDTFYVIELDERRVFLFEQIV--------------IFSELLRKGSLTPKRSIKMNYL-----EENVDNDPCKFALMNRETSERVVLQ------AANADIQQAWVQDINQVL---TQRDFLNALQSPIEYQRKERSTAVMRSQPARLPQASPRPYSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLG....................................................................................................... 621
9 -7.320[T] KOG4717 Serine/threonine protein kinase  ali follow..  9  1................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAGFKRGYDGKIAGLYDLDKTLGRGH--------KLARHVFT------GEKVAVKVIDKTKLDTLATGHLFQEV--RCMKLVQHP---NIV-RLYEVIDTQTKLYLI-DMFDYIMKHEEEDLPKKYFAQIVHAISYCHKLHVVHRDLKPENV-VFFEKQGL----KLTDFG-------FSNKFQPGKKLTT---GS-SAPEILLGDEYDAPA-----------------VDSLG--VILFMLVCGQPPANDSETLTMIMDCKYTV-VSKECKDLITRMLQR--DPKRR-ASLEEIENHPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIAD---RDAIVEALETNRYNHITATYF--LAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDD....................................................................................................... 415
10 -7.300[U] KOG1062 Vesicle coat complex AP-1, gamma subunit  ali follow..  14  7......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GTRLRDMIRAIRACKTAAEERAVVRDIRALINEDDPHDRHRNLAKLM-FIHMLGYPTHGQMECLKLIASPGFPEKRIGYLGLMLLQEVLMLVTNSL-NQYVVGLLCALGNICSAEMARDLAPEVERL-IRKKAALCSTRIIR--KVPDLAENFVNAAA----SLLKEKHHGVLVQLCYELCTINDE-CTEGLIKTLRDITNSAYQPEYLLRLLRVLGQGDADASDLMTDILAQVATKTESNKNGNAVLYECVETIMAIEDTNSLRVLAINILGRFLSNRVALNMLMKAITFDDQQRHRVTILECV-KDPDASIRKRALELVTLLVNENNVTQLTKELIDLEISDEDFKEDLSAKI-DQMLKVLCEA-GKFVKDDV...................................................................................................................................................................................... 441
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Dunbrack RL Jr, Dunker K, Godzik A. Protein structure prediction in biology and medicine. Pac Symp Biocomput. 2000;(12):93-4.