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Query: [O] COG5116 26S proteasome regulatory complex component, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTMVYSDNTSIITSAGGLMALLDEQERELQVHALLKIYEFIDQLWPEISDDVTKIEVMYEDHSFPERELAALVVSKVYYYLGEYDEALLFALSSGPKFLHDKNSDYKETLIFKCIDMFIHKSAELYKNPKADPLDERLSGVVEGIFQKCYAKNEWRHVLGIAIEAHRLDIIEYILNADKETDLKPYVLELAMTVVLDIEFRNRLLRLLLSSFLTETEPDYFSVGKCVVHLNDASVAAKLLMKLSSQNDDKSLLTAYQLAFDLEDSAPQEFLNSVMDLLPSPSVANSEEDANADSKKEDSSPCGYIIRILSGEQTVKYDREFLYAHNNTDMLILNRTKDSLEARNSVFHNAVTFANAFMNFGTSSDSFFRDNLSWLSKANNWSKFTATAALGVIHRGYYNQAMNILRPYLPEEDAPSSSTYSEGGAFYAMGLIHANHGRGVTEYLREQLKHTEDEIVQYGLLLGIGLTGMASRDETLYESVKTILFNDNAVAGSAAGISMGLIMLGTASSAAIDEMLQYAHETQHEKIIRGLGIGIALIVYGRQQEADGIIKELNNDLDPTLRYAGMFATALAYCGTSNSKIVRDVLHISVSDVNDDVRRAAVCALGFICFKDPNALISTVELLVDSYNPHVRYGSAIALGIACANSGSNAALDLLSRLVEDATDFVRQGAMIAQAMILTQHNDQLNSKVSGIRKHFEQVINEKHEDALAKLGATLAQGIIDAGGRNVTIALQTATGSLKLSAIVGLTVFLQYWYWFPLTHFMSLSFSPTALIGLDKNLNAPKFSFISNVRPKLFAYPPKSVQPTAKTVQKVETAVLSTTVKAQARAKRAEREKASKGSNDDEMKIDKKTTEEKEATPMEMDEEKSQDISINGNSKKEEPKSETLENFTRVVPAQLPYISFNLNGRYYPVRKFTGGVLMLIDRESDKAPDLIELNRDAVPASADTEPGEQEASPPEDFEYPFDDDDLast
1 -220.000[O] KOG2062 26S proteasome regulatory complex, subunit RPN2/PSMD1  ali follow..  100  1MTMVYSDNTSIITSAGGLMALLDEQERELQVHALLKIYEFIDQLWPEISDDVTKIEVMYEDHSFPERELAALVVSKVYYYLGEYDEALLFALSSGPKFLHDKNSDYKETLIFKCIDMFIHKSAELYKNPKADPLDERLSGVVEGIFQKCYAKNEWRHVLGIAIEAHRLDIIEYILNADKETDLKPYVLELAMTVVLDIEFRNRLLRLLLSSFLTETEPDYFSVGKCVVHLNDASVAAKLLMKLSSQNDDKSLLTAYQLAFDLEDSAPQEFLNSVMDLLPSPSVANSEEDANADSKKEDSSPCGYIIRILSGEQTVKYDREFLYAHNNTDMLILNRTKDSLEARNSVFHNAVTFANAFMNFGTSSDSFFRDNLSWLSKANNWSKFTATAALGVIHRGYYNQAMNILRPYLPEEDAPSSSTYSEGGAFYAMGLIHANHGRGVTEYLREQLKHTEDEIVQYGLLLGIGLTGMASRDETLYESVKTILFNDNAVAGSAAGISMGLIMLGTASSAAIDEMLQYAHETQHEKIIRGLGIGIALIVYGRQQEADGIIKELNNDLDPTLRYAGMFATALAYCGTSNSKIVRDVLHISVSDVNDDVRRAAVCALGFICFKDPNALISTVELLVDSYNPHVRYGSAIALGIACANSGSNAALDLLSRLVEDATDFVRQGAMIAQAMILTQHNDQLNSKVSGIRKHFEQVINEKHEDALAKLGATLAQGIIDAGGRNVTIALQTATGSLKLSAIVGLTVFLQYWYWFPLTHFMSLSFSPTALIGLDKNLNAPKFSFISNVRPKLFAYPPKSVQPTAKTVQKVETAVLSTTVKAQARAKRAEREKASKGSNDDEMKIDKKTTEEKEATPMEMDEEKSQDISINGNSKKEEPKSETLENFTRVVPAQLPYISFNLNGRYYPVRKFTGGVLMLIDRESDKAPDLIELNRDAVPASADTEPGEQEASPPEDFEYPFDDDD 965
2 -220.000[O] COG5116 26S proteasome regulatory complex component  ali  100  1MTMVYSDNTSIITSAGGLMALLDEQERELQVHALLKIYEFIDQLWPEISDDVTKIEVMYEDHSFPERELAALVVSKVYYYLGEYDEALLFALSSGPKFLHDKNSDYKETLIFKCIDMFIHKSAELYKNPKADPLDERLSGVVEGIFQKCYAKNEWRHVLGIAIEAHRLDIIEYILNADKETDLKPYVLELAMTVVLDIEFRNRLLRLLLSSFLTETEPDYFSVGKCVVHLNDASVAAKLLMKLSSQNDDKSLLTAYQLAFDLEDSAPQEFLNSVMDLLPSPSVANSEEDANADSKKEDSSPCGYIIRILSGEQTVKYDREFLYAHNNTDMLILNRTKDSLEARNSVFHNAVTFANAFMNFGTSSDSFFRDNLSWLSKANNWSKFTATAALGVIHRGYYNQAMNILRPYLPEEDAPSSSTYSEGGAFYAMGLIHANHGRGVTEYLREQLKHTEDEIVQYGLLLGIGLTGMASRDETLYESVKTILFNDNAVAGSAAGISMGLIMLGTASSAAIDEMLQYAHETQHEKIIRGLGIGIALIVYGRQQEADGIIKELNNDLDPTLRYAGMFATALAYCGTSNSKIVRDVLHISVSDVNDDVRRAAVCALGFICFKDPNALISTVELLVDSYNPHVRYGSAIALGIACANSGSNAALDLLSRLVEDATDFVRQGAMIAQAMILTQHNDQLNSKVSGIRKHFEQVINEKHEDALAKLGATLAQGIIDAGGRNVTIALQTATGSLKLSAIVGLTVFLQYWYWFPLTHFMSLSFSPTALIGLDKNLNAPKFSFISNVRPKLFAYPPKSVQPTAKTVQKVETAVLSTTVKAQARAKRAEREKASKGSNDDEMKIDKKTTEEKEATPMEMDEEKSQDISINGNSKKEEPKSETLENFTRVVPAQLPYISFNLNGRYYPVRKFTGGVLMLIDRESDKAPDLIELNRDAVPASADTEPGEQEASPPEDFEYPFDDDD 965
3 -130.000[O] KOG2005 26S proteasome regulatory complex, subunit RPN1/PSMD2  ali follow..  16  39LSEEDLELKQNLEL---YVERVQDPNPELQKAALESMRQEIRASTSSMTGTLKAFHETMADSDLKKYLSDILSVLALTMSADGERESLRFRLIGTEGDIGSWGHEYVRNLAGEIAQEYTKRQSE-------EASIDDLMELVQQIVAFHMKHNAETEAVDLLMDVEDLDLLLEHVDKTNFKRTCNYLTSAARYLPGPDD--MLVLDISYMIYMKFE--EYPNALQIALFLDNTQYVKQVFTSC------TDLLKKKQFCYMIARHGITFELDDEMVAD-DDDREALQDIVNNTKLSEGYLTLARDIEVMEAKTPEDIYKAHLLDGRASSGASV---------DSARQNLAATFVNAFVNAGFGQDKLMTSSGNWLFKNKEHGKTSAAASLGMIQLWDVDSGLSQLDKYFHSNDN-----PIIAGALLGVGIVNCGIKNDCDPALLGDYIDKEDSSVRIGAIMGLGISYAGSQNDQVLIRNKLSPILNDADVIAFASLSLGMIYVGSCNEEVAQSIIFALMDELGDALTRFLPLGLGLLYLGKQESVEATAEVSKTFNEKIRKYCDMTLLSCAYAGTGNVLKVQDLLAQCGEHLEKGDIHQGPAVLGLAMVAGVDMEIRSLERMLQYGEQNIRRAVPLALGLLCISNPKVTVMDTLSRLSHDTDSEVAMSAIISLGLIGAGTNNA------RIAGMLRNLSSYYYKDMSLLFCVRIAQGLVHMGKGLLTLSPFHSERLLSPTALAGIVTLLILGKYHYVLYFLVLAMQPRMMLTVDENLKPLSVPVRVGQAVDVVGQAG-----RPKTITGFQTHSTPVLLAAGERAELATDKYIPLSPILEGFIILKENPDYREE.............................................................................................................. 893
4 -128.000[O] COG5110 26S proteasome regulatory complex component  ali follow..  14  37..QLSEEDAKLKTDLELLVERLKEDDSSLYEASLNALKESIKNSTSSMTPTYPDLCSIYDKWTDPNKSSLADVLSILAMTYSENGDSLRYRLLSDVSDFEGWGHEYIRHLALEIGEVYNDQVEKDAEDEGFEFSKEDTLRLCLDIVPYFLKHNGEEDAVDLLLEIESIDKLPQFVDENTFQRVCQYMVACVPLLPPPED--VAFLKTAYSIYLSQN--ELTDAIALAVRLGEEDMIRSVFDAT------SDPVMHKQLAYILAAQKTSFEYEGV------------QDIIGNGKLSEHFLYLAKELNLTGPKVPEDIYKSHLDNSK--------SVFSSAGLDSAQQNLASSFVNGFLNLGYCNDKLIVDNDNWVYKTKGDGMTSAVASIGSIYQWNLD-GLQQLDKYLYVDEP-----EVKAGALLGIGISASGVHDEPALLLLQDYVTNPDTKISSAAILGLGIAFAGSKNDEVLGLLLPIAASTDLETAAMASLALAHVFVGTCNGDITTSIMDNFLIELKTDWVRFLALALGILYMGQGEQVDDVLETISAIEHPMTSAIEVLVGSCAYTGTGDVLLIQDLLHRLTPKNVKGEEDYAVLGIALIALGEDEMSLRHFGHLMHYGNEHIRRMVPLAMGIVSVSDPQMKVFDTLTRFSHDADLEVSMNSIFAMGLCGAGTNNA------RLAQLLRQLASYYSREQDALFITRLAQGLLHLGKGTMTMDVFNDAHVLNKVTLASILTTAFMLKHHQLFYMLNAGIRPKFILALNDEGEPIKVNVRVGQAVETVG-----QAGRPKKITGWITQSTPVLLNHGERAELETDEYISYTSHIEGVVILKKNPDYREEE............................................................................................................. 993
5 -31.600[A] COG5181 U2 snRNP spliceosome subunit  ali follow..  8  473ARAEGREIISNLAKASGMRPDIDHVDEYVRNTTARAFSVVASAL--GVPALLPFLAVCRSKKSWQARHTGVRIIQQIALLLGCSILPHLKNLVDCIGHGLEDEQQKVRIMTALSLSALAE--------AATPYGIEAFDSVLKPLWSGVQRHRGKSLAAFL----KATGFIIPLMEPEYASHFTRRIMKILLREFNSPDEEMKFFHCFWSRRMASDRRSYKQVVETTVVLAQQVGSRQIVERVVNNFKDESEPYRKMTAETVDKVIGSLGVSEIDERLEELLLDGVLFAFQEQSVEEKVICFSTVVNALGTRCKPYL-------------QIVSTILYRLNNKSANVREQAADLVSSITIVLKARKLGVVLYEYLGEEYPEVLGSILGAIKAI--------------------------------VSVVGMSSMQPPIRDLLPRLTPILRNRHEKVQENTIDLVGKIADRGSEMRICFELIDMLKAHKKSIRRAAVNTFGYISKAIGPQDVLATLLNNL-KVQERQNRVCTTVAIAIVA--MPFTVVPALMADYRTPEMNVQNGVLKSLAFMFEYIGEVYAITPLLADALMDRDAVHRQTAASVIKHLSLG-EDAMIHLLNILILEESPHVINAVREGIDGIRNCIGVGPIMAYLVQGLFHPSRKVRNTYWTSYNSAYVQSADAMVPYYPHVDDDQ--------FNNYDMKTLHICI........................................................................................................................................................................................................................................................ 1188
6 -28.200[C] COG1413 FOG: HEAT repeat  ali follow..  13  1...........................................................................................................................................................................................MPVHMKLADFKTYKLELFFFSILVVLSYALFSGNDSGTGTESMNN-----YFWVPSTVMQSIAAVYAVFIAIFALSLQRNLDSIHSIANRLKPPLKIVSYTAVGSIYLNGLMLIIFSLHSSLVASLIAIVYLSMEMLSDVSGLKTSSEKFTYLTNLLRELEGWSSSGQMELS-----PGDMELCVQGLEDEKPEVRIAAAQLLGWL---GDEQAVDALLRKLADKNPR-----VREAAVEALGRV----GDENIVAELIGCLEDKNKGLRLQAVRALSRL----GDERAVDPLVKKLEDKAPEVQAAAAEALGNLKSQDSMDVLLKKLEESPMAGAPTEFQVQVLTALGKI--GDEKALAAILSRL-DSPYPDIRKHAAEALG----NLRDEKAVPHLVK-KLADISPEVRNASVYALGNL---GDERAVSPLLRMLEEPDPELRITAVYALGNL----RAPQAISPLINMLDDDNPWVRKCTAEALGKI--GDIKATDPLVKNL----------DDPDSNVRWAAAEALRMLDKRDLRKDS............................................................................................................................................................................................................................................ 504
7 -25.100[R] KOG0567 HEAT repeat-containing protein  ali follow..  12  3....................................................................................................................................................................................................................................................................................................................................................................................................................................................SQQQIEAIGGVLNNKERPKERFRALFTLKNI----GGGAAIEAISKAFDDDSALLKHELAYCLGQM----QDAQALDILTKVLKDTTQEPVRHEAAEAMGAI--GHPDVLPILEEYK-QDPVVEVAETCAIALD-PSPPTAGDKSVTELKAIYLDAQQSFDRYRAMFSLRNL---RTEESVLAIAEGLKDSSALFRHEVAFVLGQL----QEPCSIPFLQENLEDRLENVRHECAEALGAIATEDC------IQILNRYA------EDDKRVVKESCVIALDMCEYENSPEFQ............................................................................................................................................................................................................................................ 290
8 -20.100[YU] KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily)  ali follow..  10  1MA---QPDQHELEQVIQLLQHAHSTDRDVQRNVQVQLVQLNEH--QKFCCYLVYISDMKEMIDATSRSLAGLLLNNIRAKWNKYPQDVKFFVRTTCLKSIGDQEPLIRATVGIIVTTIVM-----------EENMCDWPDLLDTLATVLMQPDELMQEGALGA----LQKVFEDSADRYESEFLRPIMPKLLVFYEHHAAKDQFLTSLFARHNDNDEEVQKQLCRSLTLLLDTPNVIEYIIKKTQDHNESIALEACEFWLSIAENSCRTMVLPHLDKLIPVLLGSMRYSETDPALKANDEDSSVPDREEDIKPRFHKSKQHGLGGLVESDDEEDEDDDDDGGGDWNIRRCSAASLDVLASIFGKDKLFPLLKDTLMNDNWLVKESGILALGAIAEGCMDGVVPHLGELIPFAMMFDKKPLVRSITCWTLSRYSSHIASDEVLANLLRCSLDGNKKVQEAACSAFATLEEEAGEGEILDQLVKAFQCYQAKNLLILYDAIGTLANSVGDQMLMPPLMEKWERLSDEDKELFPLLCISAIVSAMGQSFLPYIQPVFEAPETDFIIVALDLLSGLAESLPEHSKLVELMLFCSLDVTPDVRQSCFALLGDLTKACPERVLPQSSNFLDPSKISVCNNAIWALGELALKMGPGPIIEPLIVVINNMQRTLLENTAITIGRLGQCCGEELAPHISRFVRPCCYSLRNIKDNAEKESAFIGLCNMINMNPVGVAIASWTVPTDSLRVLFAGILQSFKQQVGDFNWNNFILQLPPPLRERLSAFYQI......................................................................................................................................................................................... 883
9 -18.900[U] COG5215 Karyopherin (importin) beta  ali follow..  9  1......MSTAEFAQL--LENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLS--SQVLIDENTKLEGRILAALT-------------LKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIADIELPHGAWPELMKIMVDNTGLLALGYMCESSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMERE--------GERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSLYYTFMKPYMEQ-------------------------LYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQ------------------------------------NITADNWRNREAAVMAFGSIMDGPDKHQALPSILNLMNDQSLQVKETTAWCIGRIA-SIDPQQHLPGVVQACLIQDHPKVATNCSWTIINLVEQLAEAYPALVDGLIGDNEFNARASAFSALTTMVEYATDSTFVMDKLGQTMSVDENQLTLNILTVLAAVIRKSPSSVEPVADMLMGKDSAFIEDDVFYAISALAASLGKETFSPYLLKALNQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDI..................................................................................................................................................................................................................................................... 709
10 -18.700[YU] KOG1241 Karyopherin (importin) beta 1  ali follow..  8  1......MTSDIAMQLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEI--VNTANSAVARMAAGLQLKNHLTS-HQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIELPINR--------PMLIQTLVNKVVSEGSSEMHRESALEAIGYI--CQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVRLAATTALHNSLEFTKSNFEKD--------MERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQ-------------------------LFPITLAAMKSDNDAVALQGIE-----SNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPVLVEKLTKQDE-PAKAASVCLMVLATCCEDEIVPHVLPFI-KENIESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMYDSSVIVRDTIAWTFGRICINETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEEYIITQLLETTDRSDGAQLRCAAYQALMDMIKNSPLDCYLVVQRTTLHQFNDLQSLLCATLQSVLRKVHESDAIMTALLTMFNGKSGVVQEEAFLAVSTLVEL-PAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDNEIMTVLINNLTEPTITVKPQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDAN.................................................................................................................................................................................................................................................................. 756
11 -17.600[U] KOG4224 Armadillo repeat protein VAC8 required for vacuole fusion, inheritance and cytosol-to-vacuole protein targeting  ali follow..  13  86...........................................................................................................................................................................................................................................................................................................................................TIEPVLFLLQSPDAEIQRAASVALGNLAVNAENKALVVKLIRQMMSPHVEVQCNAVGCITNLATLDENKALGPLTRLAKSKDIR-----VQRNATGALLNMTHSYENRQQLVVLVSLLPSSDTDVQYYCTTSISNIAVDAVHRKLVRSLIQLMDTSSPKVQCQAALALRNLASDERYQIEIVQSLLRLLRSSYLPLILASVACIRNISIHPLNELRPLVDLLSCTENEEIQCHAVSTLRLAASSERNKRAIIEKLRCLILDAPVSVQSEMTACLAVLALSDEFKICNVLIPLTDSMSIEVQGNSAAALGNLSSNVDDYSIHGYLVRFLSSEDSTFAHIAAWTIVQLLEAGVPRLTAFIQSSDDIIELLNDIVARDANNGEYEDGEGDVILLSGRA............................................................................................................................................................................................................................................... 540
12 -16.200[S] COG5369 Uncharacterized conserved protein  ali follow..  8  1MVAINDSTDSSFF----KENPKIFKDEHELLRYIVPFKNWVRKEYAIRNGAPKLLLNLFSLENLSMKYQVFVVLNSLMS---EDQDPFVQFLRHE-----------LLSVMQMI-----------------SKRDSTPYGMLNITLKVFNTMLSFDKAAEYVTQLHSDSIINQMFDKEQPSLDVLRISNLSSKILHRLILYNSKVGDS------------PRFCSALFQITNRATQLRLYSRRRFWNDCSILITN-----------SLGTLNAYLKQHVKSYKQREKTRLESNGHVSPRDMDLDEIENVFEGNKDKVALFKSEIFGPNGDEYITQLFCLVRQFDPCIRLLSISCLVTLYKAGILSKNQTKEIQ-LFFESREAKQIAPRILAII-----------------NENEIMQKTAVNAGFIDAAKYL-----EYATKEEENEINFLSDELQSSAACECLLSLSRSVYDADVSEPLIKLLSDPDTRVKSTATSAICNLVLKFSPLREFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQSKLVELCNDEDLGVQEQMLQVLRNFTCQKEEMELLAKILLEKLESKNPILIEPSIYILVHIAASDGELLLLLVKEIMLQEAQRLKPEQMSTNVSSPESDSEMDPFDIYEEDTYEPNSEILLAGIWLCINILWPKQCTSPSQEDKFGECLQMLQ--NHSSPDVRERVKDALMYINVTD................................................................................................................................................................................................................................................. 729
13 -16.200[R] KOG1293 Proteins containing armadillo/beta-catenin-like repeat  ali follow..  8  1MVAINDSTDSSFF----KENPKIFKDEHELLRYIVPFKNWVRKEYAIRNGAPKLLLNLFSLENLSMKYQVFVVLNSLMS---EDQDPFVQFLRHE-----------LLSVMQMI-----------------SKRDSTPYGMLNITLKVFNTMLSFDKAAEYVTQLHSDSIINQMFDKEQPSLDVLRISNLSSKILHRLILYNSKVGDS------------PRFCSALFQITNRATQLRLYSRRRFWNDCSILITN-----------SLGTLNAYLKQHVKSYKQREKTRLESNGHVSPRDMDLDEIENVFEGNKDKVALFKSEIFGPNGDEYITQLFCLVRQFDPCIRLLSISCLVTLYKAGILSKNQTKEIQ-LFFESREAKQIAPRILAII-----------------NENEIMQKTAVNAGFIDAAKYL-----EYATKEEENEINFLSDELQSSAACECLLSLSRSVYDADVSEPLIKLLSDPDTRVKSTATSAICNLVLKFSPLREFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQSKLVELCNDEDLGVQEQMLQVLRNFTCQKEEMELLAKILLEKLESKNPILIEPSIYILVHIAASDGELLLLLVKEIMLQEAQRLKPEQMSTNVSSPESDSEMDPFDIYEEDTYEPNSEILLAGIWLCINILWPKQCTSPSQEDKFGECLQMLQ--NHSSPDVRERVKDALMYINVTD................................................................................................................................................................................................................................................. 729
14 -16.000[U] KOG0166 Karyopherin (importin) alpha  ali follow..  12  128........................................................................................................................................................................................................................................................................................................................................................................................................................................................VARFVEFLKRKENCTLQFESAWVLTNIASGNSLQGAVPIFIELLSSEFEDVQEQAVWALGNIAGDS-DCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPENVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNHLLSSPKESIKKEACWTISNITAGNRDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENI..................................................................................................................................................................................................................................................... 450
15 -15.200[U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4, beta subunit  ali follow..  11  4..............................................................................................................................................................................................................................................................................................................................SKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIA--AMTVGKDVSSLFPDVVNCMQTDN---ELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHD--EDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLASGEPEVQYVALRNINLIVQKRPEILKQEIKVFKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK------YESIIATLCENLDSLDEPDARAAMIWI---------YAERIDNADELLESFLEGFHDESTQVQL----TLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRG..................................................................................................................................... 523
16 -14.800[U] COG5064 Karyopherin (importin) alpha  ali follow..  10  1.................................................................................................................................................................................................................................................................................................MESRYLSDRRSRFKSKGVFKADELRRQREEQQIEIRKQKREESLNKRRNLNAVLQNDIDVEEEADQSQVQMEQQMKDEFPKLTADVMSDDIELQLGAVTKFRKYLSKETHPVVDRFVQFLESEHHL-----LQFEAAWALTNIASGTTDQTRIVVFIQLLSSPEKDVREQVVWALGNIAGDSSGNGVLQPLLNILQSSASDVSMLRNATWTLSNLCRGKNPPPNPILAKLLYSEDVEIIVDACWAISYLSDGPNEKIGAILDVLLSSPSVNIQTPALRSVGNIVTGTDAQTQALNAFPSLLSHQKENIRKEACWTISNITAGNTQQIQAILVHLLSYADYKTKKEACWAISNATSGGLGQPVIKPLCDMLNGSDNKIIQVALDAIENILKVGEMDRTMDLENINQYAVYVEEASSGNNDIYLKAYSIIEKYFSDEDAVEDLAPETE...................................................................................................................................................................................................................................... 514
17 -14.400[BD] COG5218 Chromosome condensation complex Condensin, subunit G  ali follow..  8  3CIQIISSSQTSIAGHRKLCNKLFTLRTQ-GNSNADRVLRFLVTFVNYLQQKLKHILRGLDAKDKTVRYRCCQIIARVVNCVKEIDDDLYNTLKEKLLSRVLDRESIVRLEAVVALSRL--------QEDTGDEENDVRNILLFLLQNDPSSEVRRSVLLNIEVSNSTLPFILERARDVDAANRKCVYARVLPKIGDFRYLSKKRVRILKWGLNDRDESVEKAAADMLAYQWIENADNNLLELLERLDVSNNSDVAVLAIKKFFDVRVDSLSQLEFPEQFWLELTAESSLLNYTDLLDKMPEVVQLTYYIERQYVSLRDKSSYDESCFIIEQLLYIGLSQDMVDEIGRRKLLKSLTNSLSTMALPDSLISLHIELLRKLCSSENDFCSLLVEIITFEQGHSQNQTEEQGNSNAPELNKNDYEGEEITVSQKSPSPSLPPNELNEPEPDDMDGYKEAFNELRCLSY---------------VQCLFENITSSLNENLYM-----------VDMLKTLIIPAVRSHDLPIREKGLECLSLVCLLNADLAFENVPLYLEKGSVVLKCTAIRTLGKAKFTEYEDAISSILFEALGEFENAELQTLGAEAIAKLLVILHYRDELFLKPLITVDNHALRQVLGYFFPVYAFGAHENQALLSLLEIYRDLDEDDVQLSIGHIAQQMLDWTDN--EKLYERKTQTGDDYIALNHNVHLHLANMIFESLPNASEGKERKF---------------------------MISLLGK-------LKIPTDLPSSDYQRTKRKLETYESHGFTMDSTSLSILAKFERMLLQNEEARSKFEETEEERLMENAEENEHAGAEAISGEIIPDTVEANMEDEEEVYVKQEED........................................................................................... 874
18 -14.400[U] COG5240 Vesicle coat complex COPI, gamma subunit  ali follow..  10  1...................................................................................................................................................................................................................................................................................................................MSYSKKDDDGDESIFANVNQVTVTQDARAFNSSSISPRKSRRLLSKIAYLIYTGEHATELFFGITKLFQHKDPSLRQFVYIIIKELSVVAEDVIMITSSIM--KDTATGRETIYRPNAIRSLIRVIDANTVPAIERILTTGIVDPISAVASAALVSAYHLYPVAKDSRWNNEVQDAVTSHNVGRKVASSPFFTSTLGYTPNAYHALGLLYRIRRHDSIAMNKLLQL-ISSLMDQNTQFRDQMVPFLKSKGDMVNLEVARNMVRLKNISDDDLQPVVSVLKIFLSSHRSATRFSAIRTLNELAMTRPHLVHSNIESLITDVNRSIATYAITTLLKTGNDESVDRLMKQIVTFMSDISDNFKIIVVDAIRSLCLKFPRKQDSMLTFLSNILCDEGGYEFKRAAV----------------DAISDMIKYIPESKERALAELCEFIEDCEYPKIAVRILSILPTRFIRYIYNRIMLENAIVRSAAVSALFGLNAEDKFVQRSVKVILTRCLEDADDEVRDRA........................................................................................................................................... 550
19 -14.200[U] KOG1078 Vesicle coat complex COPI, gamma subunit  ali follow..  10  52..............................................................................................................................................................................................................................................................................................................................................................................................KLLYLLNQG-FTKVEATEVFFSVTKLFQSKDTGLR----RMVYLIIKELSPSSDEVIIVTSSLMKDMNSKIDMYRANAIRVLCRIIDGTLLTQIERYLKQAIVDKNPVVSSAALVSGLHLL--KTNPEIVKRWVQEGIQSRSALVQFHALALLHQIRQNDRLAVSKLVSCLRHKAEMVILEAARAITELDGVTSRELTPAITVLQLFLSSPRPVLRFAAVRTLNKVAMTHPMAVTN-MESLISDQNRSIATLAITTLLKTGNESSVERLMKQITNFMSDIADEFKIVVVDAIRSLCVKFPLKYRSLMTFLSNILREEGGFEYKRAIVDSIVTIIRDIPDAKESGLLHLCEFIEDCEFTYLSTQILHFL---------EGPNTSDPSKYIRYIYNRVHLENATVRAAAVSTLAKFGFMVESLKPRITVLLKRCIYDSDDEVRDRATLYLSEPSEEAFDINSVPKEVKSQPLAEKKAQGKKPTGLGAPPAAPASGFD........................................................................................ 567
20 -13.700[U] COG5096 Vesicle coat complex, various subunits  ali follow..  9  1............................................................................................................................................................................................................................................................................................................................MSCWTLVQQDFLEAPSVDALKTSLESKNDYVKISAM-ILRVVINGDSLPSILMHVIRFVMPSRNK----ELKKLLYY--------------YWEVCPKYNNDGTMKQEMILACNSFRND-------------LQHPNEFIRGATLRFLCKLKEPELLDPLIPTVRQCLEHRHAYVRKNAILAVFSIYQVSNHPDAASLAEDFLAAESEGTCKRNALIVLFTI---DPEKAKAWLLANFEQIPSLNASSLLVIIEFIRKDGLEKLRFQSLLVSLTATNNSSVVFEAATSVINVFPDAELAASRLLALADREADNNAKLIMLDRISQLAARDKSEDLITDVIPFLSSSDFDVCEKAISIIMGLVSSRN--VEDILNHFQKELTKSNGETEKDDGRRRALTKAIHSCAI---QYLLSHISDFQSKSASSVLSFIK----------VMEKFPDLRSSNITKLLLSLKELRAGKIFRGVIWIAGEYCLTEDDIRVAWKSIRASLGEVPILASEEQLLKDVSNVPEDDLLIDISAPASTSRKVLPDGTYATESAVTSEALSAAR........................................................................................... 534
21 -13.400[BD] COG5098 Chromosome condensation complex Condensin, subunit D2  ali follow..  8  285.....AKDTTGPKAISNFLIKLSELSPGIMLRQMNLVITLLNNSSITLCSVVEACGNIVPQTMEHYKQQIAVLIELLEERFQDSNPYVR-KICDLSSKFNKSKAKFTSLAVRSLQDRSSLVRRNSV-----------------KLLSKLLLKHPFKAIHGSQLRLSEWEEYLKGSESQLNSTLKKVESQETLNDTIERSLIEEEVEQDEGQCRTELEGSFNKSAELSRIENEVENINATNTSVLMKLKLMIVYYKDAISFIKEIHKSIELISNLLFSKNRNEVLESMDFLVLADIELSEFGIKKMLHLVWMKGTNDEGTSISVHLIECYKQLFLTAPDSCNMQEKAAHIAKNLINLSIGASIADLASLEQLLGMMYE-QKLIDQHVINILWAIYNSASKASMQKEQNVNNRDSEKGFSKEQIHGSIIILGMLSLADNEESLLNIGLGAVGLKDLTLCRYSCLALERMVPKRSEDVAVKKLYAIIINYTKDNEPMCEQALSALFISSKPDILATDLIREKTMSSRVVSLSQLLFIVGQVAIKTLVYLEKCEAEFKKNEDDFTDAIQFVKENELLFGEKSIPIVEEIVSNSSRFSDPMLQRTATLCLEKLMCLSSKYCEKLITVMEKSPDPTIRSNAVLGLGDMAVCFNNDENTDYLYRRLHDENLMVQRTCLMTVTFLILAGQVKVKGQLGEMAKCLD------NPDQGISDMCRLFFTELASKDNAIIFSNLSSDDLLGKESFKKIIKFL-----------LTFIDKERHQKQLNEKLVGRLRKCETQKQWDDIAFVLNNLPYKNEDVTALLEQGFKVVSAKE.............................................................................................................................................. 1176
22 -13.400[S] KOG4646 Uncharacterized conserved protein, contains ARM repeats  ali follow..  13  11...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VGRLGYLQALVTEFQETQSQDAKEQVLANLANFAYDPSNYEYLRQLFLDSLSEENETLVEFAIGGLCNLCPDRANKGVPLIINCLSSPNEETVLSAITTLMHLSPPGRSFLVVQCMLRFSLSASARLRNLAQIFLEDFCSPRQVAEARSRQAHSALGIPLPRSVAPR................................................................................................................................................................................................................................................................... 196
23 -13.300[T] KOG4500 Rho/Rac GTPase guanine nucleotide exchange factor smgGDS/Vimar  ali follow..  10  4.............EIDDLIEKLKTTS--VSPANTTNLLCEISAT--DKHELAECFLGLTKCDDTNVRKEAAKCIAEIT-----KSEVQRKKFTK-----------------RNIIAAFLECLRQVPTSDGSMELPIQICRALGNI---CYLNDEARDLI---LELEGDAVLLRLLDITTIE-----------DVANAAQFIKVRGGLLSNYLLGGE-----GLAKRAMELGVMKKLQGIIDIGASNVEQHEDLLLNTLPLLSILTENVSDLN---------DSSLNIQLSRILAASTNPDLAEMCLELLHYQAESDEVKLILAKDGLCETIYNLLEKYKTLASTSEARALMKLACELIVLILTGDDLLKNMVDWLDSTDIDLLTTGVLALGNFARTDSH----------------------------CIYFVEQQTMNKLLEVLAKNNGVKDDVRLQHALLSALRNLVIPKPNKNLVQTILPMLEIHQPPVVFKLLGTLRMTVDGQKNKTLIEQLVHWSKSSDYAGVTGESLRLMAWL-IKHAYLSKIAYALPRKGDAPAEQIADKIPLTQDYDRSSLSEFLAEAMVSMLTAQHLVMQNEALIALCILSVVYLSQPSEAAQ-------------AQLLQDELVKCEVGKKLAELISKSSDTMTKEIVENLQNCVNLLKSSEQLVAHLEQHNINELLKSIPILTEY.................................................................................................................................................................................................................................................................... 631
24 -13.100[O] COG5656 Importin, protein involved in nuclear import  ali follow..  7  1...........MVQEQAILSCIEVADAKIIKEAEQQLFEF-----QKQPGFTSFLLNIVSDDNFALNRLSSAIYLKNKIH-ADEKLSIKERL---ETLVKNCENNHIRPILTETINGILV-----------GQEDWDLAPIIKNLLS-SGDASYIYPGLLLLFQLCKAHRWDMVGSRDYIDSVIEELFPIVEGIASNDYRSNEILYLILKSFKYACLNNLPQYFSQPERIMS-QLHLYLCSKLPVEVMELDPADRSLDKRVKVNKWGFGNLNRFLQRYNKITKAITKEFIDYIFNTIVPIILREFFKDIEAWGNNSLWLS--DSSLYFLISFLEKCVTIDQLYPLIEPHLQIIFENVI-NEQSIELLEDDQEEYTRRYFDSTPDAASADFIFLIGSKRPEKLNNILPFIDANSSDINMAFKEEGALRTLSNLFSFIDEPFGHFIVPLLSQDKYMFLVARSLETIALYSEEFKDMNILSTYTNFLNSNVLPVQIEAADAIKCLIVSNPQPGMMEKLLKLSKIFEIDILSEVMEALVERFSDELSPFAKDLASNLVEQQALVENPSETYSASDQEQEIQASGLLQTMTTMVMSMNKVPLIESLAPVVKFVVLHA-TEAVDLLDALTISSHLLYNQIAPPI-----------ELLHDILDSFQTYAMDYFEAYSIFFETIVMTGFPQDQTYVQPLLEILSAKLESEVDYDIEHVMQILMYFALSMRDPLFSKAIKVSTNDELGLDSKCIVKLGLANLFAKPIETLQIMENEGFTINFFTNWFNEKFYSVFAIKLQVLVI----------------LTLLKMPEVPNSVSPLLNNLTNKLVELTLSLPKAIRNRDAVTEGKSLEGDLTPEEEEEYFIECDDDMKETVLDNVFQEVHTFFKNLQNEDAGKYE----------IINYLDESKRDSLQVILEFVSQH......................... 944
25 -12.200[YU] KOG1992 Nuclear export receptor CSE1/CAS (importin beta superfamily)  ali follow..  8  23.PAIRRPAEKFLESVEGLLTLLEKSDNVIKVCASVTFKNYIKRNWRIVEDEPNKIANIVHLMLSSPEQIQKQLSDAISIIGRDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKATIELCSTHANDASALRILFSSLILISLPEFWEGETWMNNFHTLLTLDNKLLQTDDEEEDNAALYAQKYDEEFQRYLPRFVTAIWNL--VSNAIQFLASVCERPHYKNLFEDQNTLTSICEKVIVPNM-----EFRAADEEAFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNPSKHKDAAIYLVTSLASKAQTQKHGITQANELVNLTEFFVNHILPDL--------------------KSANVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLLQAGSIVVHTYAAHALERLFTMRGPEILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEATLITQLTQKLLAVSKNPMFEAICLSIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFIPYVF------QVMSLLLETHKNDIPSSYMALFPHLLQPVLWERTGNIPALVRLL----QAFLERGSNTIAS--AAADKIPGLLGVFQKLIASKANDHQGFYLLNS-IIEHMPPESVDQYRKQIFILLFQRLQNSKTTKFIKSFLVFINLYCIKYGALALQEIFD-----GIQPKMFGMVLEKIII------------------------EIQKVSGNVEKKICAVGITNLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDD-------------TIPDEEHFIDIEDTPGYQTAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHMLSTACPGRVPS--------MVSTSLNAEALQYLQGYLQAAS........................... 967
26 -12.200[U] KOG1058 Vesicle coat complex COPI, beta subunit  ali follow..  9  23...............................................................................................................................................................................................................................................................................................................................................................................EAQLKEKFEKGGDKERIEALKKLIYMILNGEKTSQSMLMYVIRFCLPSNEHTLKKVLLIFWECVPKTDSNGKLLHEMILVCLQHPNEFVRGSTLRFLCKLREPELLEPLMPAIRACLEHRHSYVRRNAVCAIFTIYKNFEFPDAPELVTEYLEQEQDASCKRNAFMMLLHVDQAASRFIRCVYNLLQSSSPAVRYEAAGTLVTLSNVPAAVKAAASAYIDLIVKESDNNVKLIVLDRLVALRGSSSQGLVMDILRVLSSPGLEVRKKTLSLALDLVSSRNVEDMVMFLKKEINDENGKYRQELVKTLHAATIKFPDVASTIVPVLMEFLSDTNEKASSYVLQFVREAVHK------KNAILGALREGIPFIQSPTIFMSALWI-------LATYCEADGALDVLKLVKNSLGELPLVDSGQEEQKPEEQQPEQQQKQKPKVTADGTYATQTALSSTVTTSKKNEK..................................................................................................................................... 539
27 -11.900[YU] KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily)  ali follow..  9  10LQRAVSQDPIAVKDAEGHLNNWKQNDMSLRWIAIIQLRNSIDIIWRKNTKMSCNALLGSIKSENLLSIQNALVVSRIARL-PSLFHDLLGKLQQSLGTGDYDVALRLLITLHHIIKAMAGNRLLRSRQI--YKLAPELLTILQPILHSSLS--SWMMILESSKEIKDSTLLSYMQISRYTLKACRRLVVFGFQNPSESEFSERMLAFCAVHQRKLLSMLGTMLQSSRSPIVVGECLEMAFAHAFLFNKPFFDFSFYSPCLTKFPATIDYISLHYDFLGQISSHLSSYKEKFEESSKNFEKLVIMSLRVFILVIQEFCNTKSSHPE------TAQVLYNSFLVDNRINNLLDLLITKLLILKEEDFEEWTDSQQWVLEQSTQDRPCAEKLLKCFFDAYGDIIVSPFKDMIYECPKTLTQAVQQDTLISSFGVGYTQLKSIFVPNMASINDIGISRVYRRRIAIFLSDSSSEQLLEVIYKLYCSFLNCNDAVVILTTIDAFKTVL-----ENLFVHVLSLFKAFESVDARTSILSLLGTLLARAGEHVAPMESTIAS------------LLSQLWDGWKKEPLLRARVLAVMHQ--------FVNAIKAKSFEFSTFLYTVIEYCVNPESPEHVIFEADAMELWSTPETFTLLIPHLLYHLSQATSTLPFVLMIVSSYQLLDNTVLMKDYSFTIFEKLNDLLDDVKNETLQALCKTVCLLIETTPMDSRLLLSIATNDKHPQVLIEYLLVVSR-----------ISLREPELILKVCQTKNINHINHSKDRKLNTLALSSLLRTNHPDVLAVLDSIMNLWFSVLSEVEEDANGDA------------TIYYKNDDYSAVGFYLDETSEEMTRRKQLLLKDPVHSV--NSRSFFISVFMFCRDANGGMENFQNQYLSTV................................................. 971
28 -11.800[U] KOG1062 Vesicle coat complex AP-1, gamma subunit  ali follow..  11  34............................................................................................................................................................................................................................................................................................................................................CADIRALINEDDPHDRHRNLAKLMFIHMGYPTHFGQMECLKLIASPGFPEK--RIGYLGLMLLLDERQEVLMLVTNSLKQDLNHSNQYVVGLALCALGNICSAEMARDLAPEVERLIQFRDPNIRKKAALCSTRIIRKVPDENFVNAAASLLKEKHHGVLITGVQLCYELCTINDETKCTEGLIKTLRDITNSAYQPRLLRLLRVLGQGDADASDLMLAQVATKTESNKNAGNAVLYECV-DTNSLRVLAINILGRFLSNRDNNIRYVALNMLMKAITFDDQAVQRTILECVKDPDASIRKRALELVTLLVNENNVTQLTKELIDYLEISDEDFKEDLSAKICFIVEKFSPEKLWYIDQMLKVLCEAGKFVKDDVWHALIVVIS......................................................................................................................................................................................................................................................... 450
29 -11.600[OZ] COG5234 Beta-tubulin folding cofactor D  ali follow..  9  11...ISIDESLITSRLSQILDDVLDSSSHSVEKLKDVAVKYLQFC-KLLSKYVPNLSYLLKVKNIGKCNSITVILKAVRVLFPVGVQYIKELYT-NESSNNTWHFHYIVLLWLSQA-------NTPFPLNSLDDSLDVKKTIYTIAIKYLENSGIDKEASCLV--------LSRLFSRDDGLDLLLGFLHHCESSWFKRSIFYKILFSLSSFLKICPRNDCLQTV---------DVAFQFLNVAREDLVGQENSALRKLLCKCYTRYLEVIVDFLLSSVSDIDSFVRWSAAKG---------LAKIISRLPWNLAEQVIDAIIELMTENMFLNPIENTVNISITSPLVWHGAILFFALAGAGLIKYSKCLHILPLIEVGLSYEVRYGTRVTG---------------------------QSIRDASCYFVWSFYHCYSTNLILCLLQTVLFDNEINVRRAATAALGVAHFPQFRSCVFQRLFTNLQHWDVKVQQLSAFSLRQLSIKYPKSIYLPPILDYL-SVGNADFIFGYTIGLASIIGGFLSISFSVIIAAIDLQEETIIKDISDAYSVLVKFDDMEETLEVLLDYIRKCSTSKEARIVYIILQNLPNYQKKICKLLLDIYPQLHSIDYQAPVANALQNIIPFESIEEFVKELLQVCSN--SWIRKPAMKAISSLLVKDSSGKKLSEDIVWCCISYIIRQTFDKDSLRGLAYQALEQI..................................................................................................................................................................................................................................................... 849
30 -11.600[O] KOG4413 26S proteasome regulatory complex, subunit PSMD5  ali follow..  9  2...................................................................................................................................................................................................................................................................................................................................................................................................................................................................EDVNQLFDAAFEFAHYPGAQNETSVLPVIFNALQPDIPGFENTLVTCLERLFKTKYGASLIPQYLQVGLKADSAVVKSLACKTVLCLLEDCDTNDVSSVQLVVNNG------------------------IYPLLLDYIINSDDEVANAASETIKSLARFPDAMDPTHLRNLAARCSSLARVRVLSLIVKLFSISRLVALDLLEAEMKGTKDTLVILNVLELYYELMEVEHSSEFVPQTSLIQLLCSIISGTSTGPYEKLRAMMISGRLLSKENIYKVVEEA-----------------------------SVKALISAIDGSLESVEMNDTDAQE-AAIDALGQMGSTTKGADLVLSTSPPAARHVVASAFDRNAHGKQLAALHALANIAGETRPKSNRIVDGKAEESLRCLIYDAAAQSTKLTPSGLFLSVLQQLVEILAKEEIINIVTDARYNCCKAIHEA--FVDDPRRLKTGDKLQEAVRSGP-SKKHRGARPEVMTGEGF........ 519
31 -11.200[D] COG5657 CAS/CSE protein involved in chromosome segregation  ali follow..  8  14.PTTSKSAEEALKVWELLLNIVAEDDINIKLAASLYFKNYIKKHWDSEEGASIRISD-------EVAEL---IKREIINLMLKSTTIIQVQLG-----------EVIGYIA-------------------NFDFPDRWDTLLPDLISKLSAVDMNTNIAVLSTAHAIFKRWRPLFRSDALFLEIKYVLD-------------RFCEPFLALFVQTNNLLRNGECKLFYDLNCQDIPEFFEDHMSEFMTAFLNYFTYTNPSLEGDEGETNVLIKVKASICEIVELYTLRYEEVFTMLYDFVNVTWTLLTTLTPDEKYDGLVGKAMAFLTSVIRIRKHAEFFQQDQVLQQFIELVVLPNICLRESDEELFEDDLEYVRRDLESRARSAIVLVRGLLDHFDQKITSVVSTHINASTNPSLEWNKKYVALQLFSAIAIKGQSTFENNIKPDLLQPAGVIHPMVLAEDIKYVFT-QQLIDIFPTILRFLEMPSFVVYTYAAIALDQLLTVRHNHNQLFLIVESASTPQKLAENDYLMKAVMRIIIMSQEAILPAASLLLNPSNPKFNHYLFESIGALIRSLSKSNALLPVFQNVLIEDVTEFIPYVLQLLSQLVEASGNLIQPCLSPALWDSKGNIPALVRLLRAMIFRGPQIEPVLGIFQKLISSKVNDHFGFDLLDRVFTVFNANILAPYINHIFFLLLSRLKNSRTERFVLRCTIFFFFVASEQTGTCGPDNLIQGVDAVQSGVFGQLMT-----IILPQAQKLALPLDRKIALGLLRLLTCDLVLA------------------PDAIYENLIIPLLTCILKLFEMPIEQAQTD-------------ADEELFMDEIDADSMSFQASFSRLATTGGKRVDPFPQITDLKQYCATEMNLANRNMGGRLSQ--------IISTHLPGDGQSVL................................... 960
32 -11.200[S] KOG0212 Uncharacterized conserved protein  ali follow..  10  2..............DNLLVRGLTHKLYDKRKATAYELERVVKGYLENVISQLANDFVYSPARGPNATFGGLIGLAAVAIALGPKIDSYMESILLPVLYCFNDSDSKIRYYACESMYNIGKV--------AKGEVFRYFNLIFDVLCKLFADTEITVK--------NGAELLDRLIKDIVMQQAATYMSSAEDIKNFKEGPVSSSIQDVPVMSTEQPRMHTFSL----------SELVPLLSERLYVINPNTRMFLVSWIRLLDSIPDLEFISYLPFLLDG-----LMNYLSDPNESIRIVTSNCLYDFLREIQKIAKVKYHILQRDEESEPDFFDSMVRRNMSDAELKEISDYVESSLRDGSFIKRILEIIIDHLGSSVPLIQEKALKWLFEFIYIAPKDVLLQIPKVLEN-PLMSNDENMRQSAKDLSQNLVILVSKIMDIEFSGSETNNKDNSLSVDF-------------RSLIEVLQKLLSNDNEETRLCALEWVLLLQRRTGGKDPIFQTLLLQLSDPSDLVVSRTLELLAHIAISHKSVLKSLLQMFAEDRK-FLNSRGNLIIRQLCNYIEGERVYTSFAGILETEENLELASIMVEVLNNNLFTAPELYD--LRKKLKQSAPKLQNIFTTLYTAWCHNSIAVFSLCLLSQNYEHAANLLSVFAEIEF-------NIDMLIQLDKLVQLIESPV------------TYMRLQLLEPEKYPYLHK-----------ALYGILMLL-----------------PQ-----SSAFRTLRDRLQCSSTPRTNTILANERLPRSRRDDPYWTDLLERLKAVQLSHQNNYREPIRATRLALAGALPSTPTATTISTTTSASGITTTASNSRDSFITRLPPTAALSTGARKKPKQ....................................................................... 811
33 -10.500[TW] KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins  ali follow..  11  353............................................................................................................................................................................................................................................................................................................................................LERAVSMLEADHMPPSRISAAATFIQHECFQKSEAILKLLQLLKVQNEDVQRAVCGAL----------------RNLVFEDNDNKLEVAELNGV---------------PRLLQVLKQTRDLETKKQITDHTVNLRSRNGWPGTLGGQGGRITRSGVRDQPDQHGLLWNLSSNDKLKNLMITLTENIIGLLDFDIFYNVTGCLRNMSSAGADGIDSLVHYVRGTDDKATENCVCILHNLSY----HSIVIRMYLSLIAKSVRNYTQEASLGALQNLTAGSKESGLQHTRKMLHVGDPSVKKTAISLLRNLSRNLSLQNEIDLVSIIPDDLLIETTASACYTLNNIIQNSYQNARDLLNTIQKIMAISAGDAYASNKASKAASVLLYSL..................................................................................................................................................................................................................................................... 847
34 -10.300[R] KOG4264 Nucleo-cytoplasmic protein MLN51  ali follow..  9  67......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPA-----------------YIP----RKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGR-REDEQAPKSYGYDIRSAH 248
35 -10.100[K] KOG4109 Histone H3 (Lys4) methyltransferase complex, subunit CPS25/DPY-30  ali follow..  10  1..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MADQTASAEVATEKMDTAEAPAAAPAASAAAPAEAESNENTTVPSNVLSANGGQQTGNQSAPRNTSTVPTR------QYL----DSTVVPI--LLQGLGALAKDRPENPIEFLANFLLREKDRYNAENQNPAGQ............. 122
36 -9.800[ODR] KOG4151 Myosin assembly protein/sexual cycle protein and related proteins  ali follow..  8  363...................................................................................................................................AETRQHVAICLQRLEEDMVFDTKRTIFKEKVDMFFNALISRCTNDDEGHKCFLITMLQGPVDIGINLITNDQLTPIMLEMAASQDHLMQGIAAELIVATVSKHERAINMLKLRALYDSEDPTVKVRALVGLCKIGAAGGDDISKATMKEEAVISLAKTCKKFLLETEKYSVDIRRYACEG-------LSYLSLDADVKEWIVD-----------------------------DSLLLKALVLLAKKAGALCVYTLATIYANL---KVDEEMVKLAQFAKHHVPETHP--VEEGAVPACVAVSKTESKNALELIARSLLAFAEYEDLRGRIIAEGGT----------VLCLRLTKEASGEGKIKAGHAIAKLGAGQRAYEVVKPLCDLLHPDVEGKANYDSLLTLTNLASVSDSIRGRILEFWFMTDHEHLRAAAAELL--------NLLFFEKFYEETVAPGTDRLK--------------------WVLYSAEVEEERLSRASAAGFAILTEDENIKSWPEVFKDIAMHEDAETQRRGLMGINIMHSSNKLCSEIVSSEVFRVLVAVTKLGTINQERAGSTEQAKRGLEAAEKFGLIKATDRE...................................................................................................................................................................................................................................... 948
37 -9.660[U] KOG1077 Vesicle coat complex AP-2, alpha subunit  ali follow..  10  1...........MRGLAVFISDIRNCKSKEAEVKR-------------INKELANIRSKFKGDKTLDGYQKKKYVCKLLFIF-----LLGHDIDFG----------HMEAVNLLSSNKYSEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNP------VHVNLALQCIANIGSRDMAESFSNEIPKLLVSGDTMDVVKQSAALCLLRLFRSSPD------------IIPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRNPDEYAVSRLSRIVTASYTDLQDYTYYFVPAPLSVKLLRLLQNYNPVTEEAGVRARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRAQFLSNRETNLRYLALESMCHLATSEFSHEEVKKHQ----------------------------------EVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEMLNYLETADYSIREEMVLKVAILA--ATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINREEVQGYAAKTVFEACHENMVKVGGYILGIAGDSRSAPLVQFKLLHSKYHLCSPMTRALLLSTYIKFINLFPEIRTNIQDVFRRSADAELQQRASEYLQLSIVASTDVLAT......................................................................................................................................................................................................................................................................................................................... 589
38 -9.650[DO] KOG1173 Anaphase-promoting complex (APC), Cdc16 subunit  ali follow..  7  36........STALFWAEKVAVLGGLEPRDIYYQA---------QCMYLLGEYHRAAHTIQHHKLEKNSLPCFNLLLESLYAAKEFTEAAN--VIQNVEVEVMTTSLINQPVDASSGCYLESNSVFGGEENHRNELLSSIYLMKGKVYEALDNRGMAMDFYVQALHKEALEALVQMLMAWEEFELMHHLPLAQQSSEADAKFILKLYESRLKKYYELISARNAEEMSPIVNPDILQFIKEFTARVQQSGSSDTQMPKVSAVKVPLTPSQFM------------SPAQKVLEDLKAPTFSLQTSLSKASSLIDASHRSMFDSSSRRRSRDHDTDTLIPIAECLDRVQRSTDLMAAEAEKCFYDC---KQCLKILNELLKVDPFHNTALTIQIACLVENGDFNRLFYVAHKLVDRYPDKAISWYAVGCYYDMIG------KSDPARRYLSKATALDRLYGP--AWLAYGHSFANENEEQAMAAYFKATQLMRGC--HLPLLYIGVECGLTKNLELAEKFFLQAMNIAPLDVYVLHELGVIKYEYEFFDGAATIFQCTVDIVKQRAKSPLFINLGHSLRKVHKYEEALYNFQYALLLKPQSPTTYTSIGFIHALLGNLDPAIEAFHKSLALNRDCIVTSTILKSCIEDLMDDSATIDEICSAALRDVAKNI---TANSRRVLNSDKFNGM-------KLKFDEEEEFANSDSN----MVVEMSFDT.................................................................................................................................................................................................................................................... 718
39 -9.450[U] KOG2081 Nuclear transport regulator  ali follow..  10  33..QDFQKSIYSWTIADELLH--QKRDLHANYFAAQTMRNKIQNSFSELPPHITHIGQIDEQTDNVIVTQLSLAVADLALLMASWREPINDLL--VTLAPHQCAIWPLLEVLKVLPEEIDSRYLR-LGANRREEVHKQLDASAECVLKFLCMCLQREDLDQQRVWNAALRTYSAWLVIHAFPALTQLAFRLLSLPETSGKLHDNATECVCALLSCIDGASDPESSFEAQLFGAVCMLETPYHLSVAHEDTDKTINYCRIFTSLCDAFFYDLLA-------------------DAQKPHYSLKGLDLVLLCVGHFDYEVAEITFH-------YKLSEDLFQRNEDKLTVLFRPHIER-LISALFRHSQMESDHDGLIEENNNFFDFRRKVSDLIKDVAFIVGSGACFKQMFHILQAPETTWESTEAALFIMQNVAKNILPDKVVEAILNMSEQTHIAVRYTAILLIGELCIENHPESLEAVLNFLLYQQKNGLAPAAAIALTSICSACRQSGLVEIARSLDSFQINNDVAIGLLKGISLIRLPREQLQPALREIVGFQLQPLAQLVDSTGSTPQKGERTDPVYWIDRACAIIRHTNPDVPDNVEHPTVAILNDAWQLISRVMDKYQSDLRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHHSCFLYVGSILVDEFAKSSECIGGLLEMLQAFIE........................................................................................................................................................................................................................................................................ 739
40 -9.360[S] KOG1949 Uncharacterized conserved protein  ali follow..  11  21.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LSCLFNWNINFIKMIHGTIKNQLQGLQKSLMVYIAEIYFRA-ENDCIQDFMFHGIHPRRSPVHSKVREVLSYFHHQKKRLYKPILWRGLKARNSEVRSNAALLFVEAF--DSKIQKQFEELYSLLEDPYPMVRSTGILGVCKITSKPPTILIDLLKKVTDTSSADVRCSVFKCLPMILDNKLSEQLLPALRYSLHDNSEKVRVAFVDMLLKI-KAVRAAKFWKICPMEHILVRL---ETDSRPVSRR---------------------------------------------LVSLIFNSFLPV--QPEEVWCERCVTLVQMNHAAARRFYQYAHEHTACTNIAKLIHVIRHCLNACIQRAVREPPEDEEEEDGREKENVTVLDKTLSVNDVACMAGLLE-KSIDRSMENNKEAKLYTINKFASVLPEYLKVFK----------DRCKIPLFMLMSFMPASAVPPFSCGVISTLRSREEGAVDKS............... 497
41 -9.230[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  8  1...........MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASS-TLLDDRRNAVRALKSLSKKYRLEVGIQAMEHLIHVLQTDRSDSE--------------------IIGYALDILYNIISNEEEEEVEENSTRQSEDLGSQFTEI------------FIKQQENVTLLLSLLEEFDF------------------HVRWPGVKLLTSLLKQLGPQVQQII------LVSPMGVSRLMDLL----ADSREVIRNDGVLLLQA-------------LTRSNGAIQKIVAFE--------AFERLLDIISEEGNSD--------------------------GGIVVEDCLILLQNLLKNNNSNQNFFKE----------------------------GSYIQRMKPWFEVGDENSGWSAQKVTNLHLM---------QLVRVLVSPTNPPGATSSCQKAMFQCGLL----------QQLCTILMATGVDILTETINTVSEVIRGCQVNQIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTLLDATGNSVSAGQLLCGGLFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPSLLQQCTNILSQGSKIQTRVGLLMLL-FLHNSANVPFLTGQIAENLGEEEQLVQGLCALLLGIIYFNDNSLESYMKEKLKQLIEK-----------RIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEF-----LVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTN----SAIVSARDSEQVAELKQELATLKSQLNSQSVE............... 807
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.