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Query: [BD] COG5218 Chromosome condensation complex Condensin, subunit G, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSCIQIISSSQTSIAGHRKLCNKLFTLRTQEGFETDILRALNIILTVKKGNSNADRVLRFLVTFVNYLQQKDPEIDIVQPILKHILRGLDAKDKTVRYRCCQIIARVVNCVKEIDDDLYNTLKEKLLSRVLDRESIVRLEAVVALSRLQEDTGDEENDVRNILLFLLQNDPSSEVRRSVLLNIEVSNSTLPFILERARDVDAANRKCVYARVLPKIGDFRYLSIKKRVRILKWGLNDRDESVEKAAADMLAYQWIENADNNLLELLERLDVSNNSDVAVLAIKKFFDVRVDSLSQLEFPEQFWLELTAESSLLARTFNEICIEKNYTDLLDKMPEVVQLTYYIERQYVSLRDKSSYDESCFIIEQLLYIGLSQDMVDEIGRRKLLKSLTNSLSTMALPDSLISLHIELLRKLCSSENDFCSLLVEIITEVFEQGHSQNQTEEQGNSNAPELNKNDYEGEEITVSQKSPSPSLPPNELNEPEPDDMDGYKEAFNELRCLSYVQCLFENITSSLNENLYMVDMLKTLIIPAVRSHDLPIREKGLECLSLVCLLNADLAFENVPLYLHCYEKGSVVLKCTAIRTLTDMLIQHGKAKFTEYEDAISSILFEALGEFENAELQTLGAEAIAKLLVILHYRDELFLKPLIIQYFEPNTVDNHALRQVLGYFFPVYAFGAHENQWRIATIFCDALLSLLEIYRDLDEDDVQLSIGHIAQQMLDWTDNEKLYERKTQTGDDYIALNHNVHLHLANMIFESLPNASEGKERKFMISLLGKLKIPTDLPSSDYQRTKRKLETYESHGFTMDSTSLSILAKFERMLLQNEEARSKFEETEEERLMENAEENEHAGAEAISGEIIPDTVEANMEDEEEVYVKQEEDLLast
1 -185.000[BD] COG5218 Chromosome condensation complex Condensin, subunit G  ali  100  1MSCIQIISSSQTSIAGHRKLCNKLFTLRTQEGFETDILRALNIILTVKKGNSNADRVLRFLVTFVNYLQQKDPEIDIVQPILKHILRGLDAKDKTVRYRCCQIIARVVNCVKEIDDDLYNTLKEKLLSRVLDRESIVRLEAVVALSRLQEDTGDEENDVRNILLFLLQNDPSSEVRRSVLLNIEVSNSTLPFILERARDVDAANRKCVYARVLPKIGDFRYLSIKKRVRILKWGLNDRDESVEKAAADMLAYQWIENADNNLLELLERLDVSNNSDVAVLAIKKFFDVRVDSLSQLEFPEQFWLELTAESSLLARTFNEICIEKNYTDLLDKMPEVVQLTYYIERQYVSLRDKSSYDESCFIIEQLLYIGLSQDMVDEIGRRKLLKSLTNSLSTMALPDSLISLHIELLRKLCSSENDFCSLLVEIITEVFEQGHSQNQTEEQGNSNAPELNKNDYEGEEITVSQKSPSPSLPPNELNEPEPDDMDGYKEAFNELRCLSYVQCLFENITSSLNENLYMVDMLKTLIIPAVRSHDLPIREKGLECLSLVCLLNADLAFENVPLYLHCYEKGSVVLKCTAIRTLTDMLIQHGKAKFTEYEDAISSILFEALGEFENAELQTLGAEAIAKLLVILHYRDELFLKPLIIQYFEPNTVDNHALRQVLGYFFPVYAFGAHENQWRIATIFCDALLSLLEIYRDLDEDDVQLSIGHIAQQMLDWTDNEKLYERKTQTGDDYIALNHNVHLHLANMIFESLPNASEGKERKFMISLLGKLKIPTDLPSSDYQRTKRKLETYESHGFTMDSTSLSILAKFERMLLQNEEARSKFEETEEERLMENAEENEHAGAEAISGEIIPDTVEANMEDEEEVYVKQEEDL 875
2 -37.700[A] COG5181 U2 snRNP spliceosome subunit  ali follow..  8  380.KILRLLLKVKNGTPPMRKALRQLTDQARDFGAAALFNQILPLLMERTLEDQERHLLVKVIDRILYKLDDL--VRPFTHKILVVIEPLLIDEDYYARAEGREIISNLAKASG-------AHMIATMRPDIDHVDEYVRNTTARAFSVVASA-----PALLPFLKAVCRSKKSWQARHTGVRIIQQLKNLVDCIGHGLEDEQQKVRIMTALSLSALAEAATPYGIEAFDSVLKSGVQRHRGKSLAAFLKATG------------FIIPLMEPEYASHFTRRIMKILLREF----------NSPDEEMKKIVLKVVSQCASTDGVTPEYLRTDVLPEFFHCFASDRRSYKQVVETTVVLAQQVGSRQIVRVVNNFKDESEPYRKMTAETVDKVIGSSEIDERLEELLLDGVLFAFQEQSVEEKVILTCFSTVVNALGTRCKPYLPQNNKSANVREQAADLVSSITIVLKACGEEALMRKLGVVLYEYLGEEYPEVLGSILGAIKAIVSVVGMS-SMQPPIRDLLPRLT-PILRNRHEKVQENTIDLVGKIA-VSAREWMRICFELIDMLKAHKKSIRRAAVNTFGYISKAIG--------PQDVLATLLNNLKVQERQNRVCTTVAIAIV--AETCMPFTVVPALMADY----RTPEMNVQNGVLKSLAFMFEYIGEQARDYVYAITPLLADALMDRDAVHRQTAASVIKHLSLGCVGLGVEDAMIH--------------------LLNILWPNILEESPHVINAVREGIDGI---NCIGVGPI--MAYLVQGLFHPSRKVRNTYWTSYNSAYVQSADAMVP...................................................... 1166
3 -31.500[BD] COG5098 Chromosome condensation complex Condensin, subunit D2  ali follow..  12  238SSLMTNLTYFLHLSVFNAELLKLLNDEYNYPQLTEDILKEISTRVFNAKDTTGPKAISNFLIKLSELS------PGIMLRQMNLVITLLNNSSITLRCSVVEACGNIVPQTMEHYKQQIAVLIELLEERFQDSNPYVRTKAIQGCSKICDLSSKSKAKFTSLAVRSLQ-DRSSLVRRNSVKLLSEIHKSIELISNLLFSKNRNEVLESMDFLVL----ADAFDIELSEFGIKKMLNDEGTSISVHLIECYKQLFLTHIAKNLINLSIGASIADLASLEQLLGMMYEQKLIDQHVINILWAIYNSASKASMQKEQNVNNRDSEKGFSKEQIHGSIIILGMLKGLESLLNIGLGAVGLKDLTLCRYSCLALERMVPKRSTIITKVAVKKLYAIIINYTKDNEYYPMCEQALSALFTISSKPDILATDLIREKTMMTFGKPEEEDSILSLEQSSRKIEAETRNGKVKNQGADVTNTTQDNGGDKELEMIGGTNEDDFTDAIQFVKE--ELLFGEKSILGKFCPIVEEIVSNSSRFSDPMLQRTATLCLEKLMCLSSKYCEKSLPLLITVMEKSPDPIRSNAVLGLGDMAVCFNNLV------DENTDYLYRRLHDENLMVQRTCLMTVTFLILAGQVKVKGQLGEMAKCLDNP----DQGISDMCRLFFTELA----SKDNAIYNGFIDIFSNL-----SSDDLLGKESFKKIIKFLLTFIDKERHQK------------------QLNEKLVGRLRKCETQKQWDDIAFVLNNLPYKNEDVTALLEQGFKVVSA................................................................................... 1174
4 -29.100[S] KOG1949 Uncharacterized conserved protein  ali follow..  10  38.TIKNQLQGLQKSLMVY-RAWKKASGKILEAIENDCIQDFMFHGIHLPRRSPVHSKVREVLSYFHHQKKRQGVEEMLYRLYKPILWRGLKARNSEVRSNAALLFVEAFNLHAIEMDSKIQKQFEELYSLLEDPYPMVRSTGILGVCKITSKPPTILIDLLKKVTGELAFDSSADVRCSVFKCLPLLEQLLPALRYSLHDNSEKVRVAFVDMLLK-IKAVRAAKFWKICPMILVRLETDSRPVSRRLVSLIFNSFLPVNQPEEVWCERCVTLVQMNHAATNIAKLIHVIRHCLNACIQRAVREPPEDEEEEDGREKENVTVLDKTLSVNDVACMAGLLEIIVILWKSIDRSMENNKEAKLYTINKFASVLPEYLKVFKDDRCKIPLFMLMSFMPASAVPP-FSCGVISTLRSREEGAVDQVGHILELVDNWLPTEHAQAKSNTASKGRVQIHDTRPVKPE------------------------------------LALVYIEYLLTHPKNRECLLSAPRKKLNHLL-KALETSKADLESLLQTPGGKPRGFSEAAAPRAFGLLSIHLQHKFCSEGKVYLSMLEDTG---------FWLESKILSFIQDQEEDYLKLHRVIYQQIIQTYLVMVGLGDHQFQMQLLSLGIMQTVKGFFYVSLLLDILITGSSLIQKTDSDEEVAMLLDTVQKVFQ---------------KMLECIARSFRKQPEEGLRVSDVEELTPPEHLSDLPPFSRCLIGIIIKSSNVVRSFLDELKACVASNDIEGIVCLTAAVHIILVINA-----GKHKSSKVREVAATVHRKLKTFMEITLEEDSIERFLYESSSRTLGELLNS......................... 888
5 -25.700[YU] KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily)  ali follow..  9  12.QVIQLLQHAHSTDRDVQRNVQVLVQLNEHQKFCCYLVYILSDM--KEMIDATSRSLAGLLLKNNIRAKWNKYPQDVKFFVRTTCLKSIGDQEPLIRATVGIIVTTIVM---EENMCDWPDLLDTLATVLMQPDELMQEGALGALQKVFEDSADR-SEFLRPIMPKLYEHHAAKMRALAMNCVNC-DQFLTSLFARHNDNDEEVQKQLCRSLTLLLDTHIEK-LPNVIEYIIKKTQDHNESIALEACEFWVLPHLDKLIPVLLGSMRYSETDPALKANDEGLGGLVESDDEEDEDDDDDGGGDWNIRRCSAASLDVLASIFGKD--------------LLDKLFPLLKDTLMNDNWLVKESGILALGAIAEGCMDGVVPHLGELIPFMLAMMFDKKVRSITCWTLSRYSSHIASDENFRQQFFKDVLANLLRCSLDGNKKVQEAA--CSAFATLEEEAGEQLIPFLGEILDQLVKAFQCYQAKNLLI---------LYDAIGTLANSVGDALSHPVYVQMLMPPLME---LSDEDKELFPLLECISAIV---QPVFTRCCSLIEKCVQQNETDFIIVALDLLSGLAESLPEHMDPLVANSKLVELMLFCSLDVTPDVRQSCFALLGDLTKACPERVLPQSSNFIFFLAQNLDPSKISVCNNAIWALGELALKMGPAMKQFIGPIIEPLIVVINSQQNMQRTLLENTAITIGRLGQCCGEAPHISRFVRPCCYSLRNIKDNAEKESAFIGLCNMINMNPVGVLNDFIFWCDAIASWTVPTDSLRVLFAGILQSFKQQ--VGDFNWNNFILQLPPPLRERLSA...................................................... 879
6 -25.100[C] COG1413 FOG: HEAT repeat  ali follow..  11  17.LFFFSILVVLSYALFGNDSGTGTESMNNYSIAAVYAVFIAIFALSLQRNLDSIHSIANRLKPPLKIVSYTAVGSIYLNGLMLIIFSLHSPSELKIELMLFTSLLSLVASLIAIVYLSMEMLSSEKFTYLTNLLRELEGWSSSGQMELSP-------GDMELCVQGL-EDEKPEVRIAAAQLLGWDEQAVDALLRKLADKNPRVREAAVEALGR-------VGDENIVAELIGCLEDKNKGLRLQAVRALSRLGDERAVDPLVKKLEDKAPEVQAAAAEALGNLKSQDSMDVLLKKLEESPMAGAPTEFQVQVLTALGKIGDEKA----------------------------------------LAAILSRLDSPYPDIRKHAAEALGNLRDEKAVPH--------LVKKLADISPEVRNASVYALGNLGDERA----------------------------------------------------------------------------------------SPLLRMLEEPDPELRITAVYALGNL-------APQAISPLINMLDDDNPWVRKCTAEALGKI------------GDIKATDPLVKNLDDPDSNVRWAAAEALRML-------KRDLRKDSNGNL.................................................................................................................................................................................................................................... 508
7 -24.400[R] KOG0567 HEAT repeat-containing protein  ali follow..  11  4.................QQQIEAIGGVLNNKERPLKERFRALFTLKNIGGGAAIEAISKAFDD-LKHELAYCLGQMQDAQALDILTKVLKDTTQEVRHEAAEAMGAIGH----------PDVLPILEEYKQDPVVEVAETCAIALDRVRWLQSGQKDKSVTELKAIYLDQQSLFDRYRAMFSLR-TEESVLAIAEGLKDSSALFRHEVAFVLGQ-------LQEPCSIPFLQENLEDRLENVRHECAEALGAIATEDCIQILNRYAEDDKRVVKESCVIALDMCEYENSPEFQYADGLAKLDATK.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 302
8 -23.200[U] COG5215 Karyopherin (importin) beta  ali follow..  9  1MSTAEFAQLLENSILSRLTSETQLKKLSNDN--FLQFAGLSSQVLIDENTKLEGRILA-TLKNELVSKDSTQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIADI--ELPHGAWPELMKIMVDNTGAEQPNVKRASLLALGYMCESADPQSQALIAIVQGAQSTETSKAVRLAALNALGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSLYYTFMKPYMEQALYALTKSPNDKVASMTVEFWST--LAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNVLEFVEQNITADNWRNREAAVMAFGSIMDQALPSILNLMNDQSLQVKETTAWCIGRIADSVADPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEATPSPIALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGLFFRLLEKKDSAFIEDDVFYAISALA---EKYLETFSPYLLKALNQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPYLNDIM-----------ALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPY-VGTIFQFI---------------------------------QVAEDPQLYSEDATSRAAVGLIGDI-IKQFYGQDWVIDYIKRTRSGQLFSQATKDTARWAREQQKRQL............................................................ 859
9 -22.100[S] KOG0212 Uncharacterized conserved protein  ali follow..  10  6..VRGLTHKLYDKRKATAYELERVVKGYLENDETEKIRAVISQLASPARGPNATFGGLIGLAAVAIALGPK--IDSYMESILLPVLYCFNDSDSKIRYYACESMYNIGKVAKGEVFRYFNLIFDVLCKLFADTEITVKNGAELLDRLIKDIVMQQAATYMSSAEDIKNFKEGPVSSSIQDVPVMSTSELVPLLSERLYVINPNTRMFLVSWIRLLDSIPDL--LPFLLDGLMNYLSDPNESIRIVTSNCL-------------DFLREIQKIAKVKYHILQRDEESEPDF--------------------------------FDSMVRRNMSDAELKEISDYVESSLRDGSFILEAHIQIDYKRILEIIIDHLGSSVPLIQEKALKWLFEFIYIAPKD-LQIPKVLENLLPLMSNDENMRQSAKDLSQNLVILVSKIMDIEFSGSETNNKDNSLSVDFRSLIEVLQKLLSN-----------------DNEETRLCALEWVLLLQRRTGG--KLINMHDPIFQTLL-LQLSDPSDLVVSRTLELLAIAISHKSVNLVPFLKSLLQMFAEDRKFLNSRGNLIIRQLCNYIEGERV-------YTSFAGILETEENLELASIMVEVLNNNLF-----TAPELYDL-----KKLKQSAPKLQNIFTTLYTAWCHNSIA---LLSQNYEHAANLLSVFAEIEFNIDMLIQLDKLVQLI-----------------------ESPVFTYMRLQLL-------EPEKYPYLHKALYGI-LPQSSAFRTLRDRLQCSSTPRTNTILANERLPRSRRYWTDLLERLKAVQLSHQNNYREPIRATRLALAGALPSTPTATTISTTTSASGITTTASNSRDSF.. 791
10 -21.800[YU] KOG1241 Karyopherin (importin) beta 1  ali follow..  10  7MQLIAILEKTVSPDKNELLSAKNLEQAAASN---PEFLKALSEILVNTANSAVARMAAGLQLKNHLTSKDEKVSQQYQDLIKNNILAALGTENTRPS-CAAQCVAYVA--VIELPINRWPMLIQTLVNKVEGSSEMHRESALEAIGYICQDIRFGNDVLTAIIHGMRKVEPSNHVRLAATTALHERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQALLAAMKSDNDAVALQGIEFWS------------------------NVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPVLVEKLTKQDECDDEDTWS--------PAKAASVCLMVLATCCEDEIVPHVLPIKENIESPNWRFRDAAVMTFGSVLNETNTLKPLVEQAMPTLIRLMYDSSVIVRTIAWTFGRICDIIPEAAINETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTNDGETPETYALSPYFEYIITQLLETTDRSDGAQANLRCAAYQALMDMIKNSPLDLQSLLCATLQSVLR---DAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLG-AQFAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTITVKPQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGIIQGLKGVDQTAHTDVMHMEPHLMHIISFIKRIAQEGDDSMLASAAGFIGDLRLYPLLDDAIITQF--LAEGKRSKAQRTKMLCTWAVKEIKKINTQVITQ...................................................... 884
11 -19.400[U] COG5240 Vesicle coat complex COPI, gamma subunit  ali follow..  10  1.........MSYSKKDDDGDESIFANV-NQVTVTQDARAFNSSSISPRKSRRLLSKIAYLIYT------GEHFQEKQATELFFGITKLFQHKDPSLR----QFVYIIIKELSVVAEDVIMITSSIMKDTATGRETIYRPNAIRSLIRVIDAN--------------------------------TVPAIERILTTGIVDPISAVASAALVSAYHLYPVAKDI-VSRWNNEVQDAVTSHNVGRKVASSPFFTST-SGISQYHALGLLYRIRRHDSIAMNKLL------------------------------------------------------------------QLLVSNLGTVSNSHAFVMLIRYISSLMDQNTQFRDQMVPFLHGWLKSKG--DMVNLEVARNMVRLKNISDDDLQPVVSVLKIFLSSHRS--------------------------------------------------------------ATRFSAIRTLNELAMTRPHLVHSCNLNIESLITDVNRSIATYAITTL--LKTGNDESVDRLMKQIVTFMSDISDNFKIIVVDAIRSLCLKF-----PRKQDSMLTFLSNILCDEGGYEFKRAAVDAISDMIKYIPESKERALAELCEFI---EDCEYPKIAVRILSILGEEGPKASEPTR--------FIRYIYNRIMLENAIVRSAAVSALTKFGLNAEDKFV--------------------QRSVKVILTRCLEDADDEVRD---RAAFSVKALEDRDAFLPVVKSDKIPSLPALERSLVIYISERKFGQGFDIKSVPVLSQEEIDAENLRIKKATTEVEFTEVTPAEDQNALASSNIETEFLNALESVSE... 654
12 -19.000[U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4, beta subunit  ali follow..  11  1......MTDSKYFTTNKKGEIFELKAELNNEK--------------KEKRKEAVKKVIAAMTV--------------VSSLFPDVVNCMQTDNLELK----KLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDK--------------------------------ITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQ--------------------------------------------NINKLLTALNECTEWGQIFILDCLSNYN------------PKDDREAQSICERVTPRLSHANSA--SAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKV-----------------------------------------KYNDPIYVKLEKLDIMIRLASQAN--------IAQVLAELKE--ATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIF-------------------------RKYPNKYESIIATLCENL---------------------DSLDEPDARAAMIWIVGEYAERIDNADE--------LLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQ---------------------ELVQQVLSLATQDSDNPDLR---RGYIYWRLLSTDPVTAKEVVLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGTTTATNLEQPQVIPSQGDLLG. 629
13 -18.500[S] COG5369 Uncharacterized conserved protein  ali follow..  9  1................................................................MVAINDSTDSSFFKENP-------KIFKDEHELLRYIVPFNWVIGRPDRKEYAIRNGAPKLLLNLFSLESMNEKYQVFVVLNSLMSEDQDPRHEDLLSVMQMISKRDSTPYGMLTLKVFNTMLSFDKAAEYVTQLHSDSIINQMFDLYTLPLKEQPSLDVLRISNLSSKILHRLILYNSKV-----------GDSPRFCSALFQITNRATQLRLYSRRRFWNDCSILITNSLGTLNAYLKQHVKSYK---REKTRLESNGHVSPRDMDLDEIENVFEGNKDKVALFKSEIFGPNGDEYITQLFCLVRQFDPCIRLSISCLVTLYKAGILSKNQTKEIQMIVTPILIRLFFESREAKQIAPRILAIIINENEIMQKTAVNAGFIDAAKYLLEYATKEEENEINFLSDELQSSAA-----------------CECLLSLSRSVYILRTGLADADVSEPLIK------LSDPDTRVKSTATSAICNLVLKFSPLREKFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLKKIGASKLVELCNDEDLGVQEQMLQVLRNFTSVDFLLKMVPMELLAKILLEKLESKNPILIEPSIYILVHIAASDGELRDSILRQ--KLLLLVKEIMLQEAQRLKPEQMSTNVSSPESDSEMDLQEDDFDREMRP------------PFDIYEEDTYEPNSEILLAGIWLCINILWPKQCTSERASILQNLGECLQMLQNHSSPDVRERVKDALMYINV.......................................................... 727
14 -18.500[R] KOG1293 Proteins containing armadillo/beta-catenin-like repeat  ali follow..  9  1................................................................MVAINDSTDSSFFKENP-------KIFKDEHELLRYIVPFNWVIGRPDRKEYAIRNGAPKLLLNLFSLESMNEKYQVFVVLNSLMSEDQDPRHEDLLSVMQMISKRDSTPYGMLTLKVFNTMLSFDKAAEYVTQLHSDSIINQMFDLYTLPLKEQPSLDVLRISNLSSKILHRLILYNSKV-----------GDSPRFCSALFQITNRATQLRLYSRRRFWNDCSILITNSLGTLNAYLKQHVKSYK---REKTRLESNGHVSPRDMDLDEIENVFEGNKDKVALFKSEIFGPNGDEYITQLFCLVRQFDPCIRLSISCLVTLYKAGILSKNQTKEIQMIVTPILIRLFFESREAKQIAPRILAIIINENEIMQKTAVNAGFIDAAKYLLEYATKEEENEINFLSDELQSSAA-----------------CECLLSLSRSVYILRTGLADADVSEPLIK------LSDPDTRVKSTATSAICNLVLKFSPLREKFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLKKIGASKLVELCNDEDLGVQEQMLQVLRNFTSVDFLLKMVPMELLAKILLEKLESKNPILIEPSIYILVHIAASDGELRDSILRQ--KLLLLVKEIMLQEAQRLKPEQMSTNVSSPESDSEMDLQEDDFDREMRP------------PFDIYEEDTYEPNSEILLAGIWLCINILWPKQCTSERASILQNLGECLQMLQNHSSPDVRERVKDALMYINV.......................................................... 727
15 -18.400[U] COG5096 Vesicle coat complex, various subunits  ali follow..  8  16.SVDALKTSLESKNDYVKSAMKTILRVV--DSLPSILMHVIRFVMPSRN---ELKKLLYYYWEVCPKYNNDGTMKQEMILACNSFRNDLQHPNEFIRGATLRFLCKL-------EPELLDPLIPTVRQCLEHRHAYVRKNAILAVFSIYQVSNHLIPDAASLAEDFLAAESEGTCKRNALIVLEKAKAWLLANFEQIPSLNASSLLVIIEFIRKVVLT-DGLEKLRFQSLLVSLTATNNSSVVFEAATSV------------------INVFPDAESLKLAASRLLAL-------------------------------ADREADNNAKLIMLDRISQLA---------------ARDKSILEDLITDVIPFLSSSDFDVCEKAISIIMGLVSSRNVE--------------------------DILNHFQKELTKSNGE------------------------------------------------------------------------------------------TEKDDGRRRALTKAIHSCAINFPHTAATAIQYLLSHISDFQSKSASSVLSFIKEVM-------------------------EKFPDLRSSNITKLLLSL--KELRAGKIFRGVI--IAGEYCLTEDDIRVAWKSIRASLGEVPILASEEQLLKDVSNVPEDDLLIDISAPASTSRKVLPDGTYATESAVTSEALSAARLEAVKASKKPP----------LRTQILSGDYYLAAVLASALTKLVMRLSFDKERLNALKAEACLIMTSIIRVGQSKFVKYTIDDDSVERIMNCIRAIYSFEELPEFQTVFLDDMRKAFSSLVAQSDKRQKEADLLVNGSDAVQADEL 674
16 -18.300[YU] KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily)  ali follow..  9  1MQVDPVVYQLQRAVSQDPIAVKDAEGHLNNWKKEPGFFGKLYSIFLD------------------------------------------KQNDMSLRWIAIIQLRNSIDI-MSLLPEERDFIRCNALLGSIKSENLLSIQNALVVSRIARLDYPTEPSLFHDLLGKLQQSLGTGDYDVALRLLITLHHIIKAMAGNRLLRSRQIFYKLAPELLTILQPILHSSLSSWMMILESSKEIKDSTLLSYMSRYTLKACRRLVVFGFQNPSESEFSERMLAFCAVHQRKLLSMLGTMLQSSRSPIVVGECLEMAFAHAFLFNKPFFDFSFYSPCLTKFPATIDYISLHYDFLGQISSHLSSYKEK-SLRVFILVIQEFCNTKSSHPETAQVLYNSFLVDNRINNLLDLLITKLLILKEEDFEEWTDSPQQWVLEQSTQDVEFNVRPCAEKLLKCFFDAYGDIIVSPFKDMIYSVFECPKTLTQAVQQDT------------LISSFGVGYTQLKSIFPFAKWLQEAVPNMASINDIGISRVYRRRIAIFLSQWI-QLLEVIYKLYCSFLNLTDPCNDVVILTTIDAFKTVLWNFSENSFLSIKENLFVHVLSLFKAFESVDARTSILSLLGTLLAGEHVAPSTIASLLSQLW--DGWKKEPLLRARVLAVMHQFVNAIKAKSFEFSTFLYTVIEYCVNPESPEHVIFEA-DAMELWSTFLMYIQKLPETFTLLIPHLLYHLSQATSTLPFVLMIVSSYQLLDNTVLMKDYSFTIFEKDLLDDVKNETLQALCKTVCLLIETTPMDMIYESLLNSSLLSRLLLSIATNDKH.................................................. 805
17 -18.100[U] KOG4224 Armadillo repeat protein VAC8 required for vacuole fusion, inheritance and cytosol-to-vacuole protein targeting  ali follow..  10  3...................................NCLSCCEKSKDEQYEPLLADREREAVADLLSFLEDRNEVNFYSEEPLRALTILAYSDNLDLQRSAALAFAEITEKDVREVD---RETIEPVLFLLQSPDAEIQRAASVALGNLAVNAENKKLNGLDLLIRQM-MSPHVEVQCNAVGCITAHSGALGPLTRLAKSKDIRVQRNATGALLNMTHS-QQLVSAGTIPVLVSLLPSSDTDVQYYCTTSISNIAVDAVHRKRLAQSEP--------------------------------------------LVRSLIQLMDTSSPKVQCQAALALRNLAS-------------DERYQIEIVQSLPSLLRLLRSSYLPLILASVACIRNISIHPLNESPIIDA-------------GFLRPLVDLLSC----------------------------------------------------------TENEEIQCHAVSTLRNLAASSERNKRAIIEANAI--QKLRCLILDAPVSVQSEMTACLAVLALSDEFLNFGICNVLIPLTDSMSIEVQGNSAAALGNLSS--RFIECWDSPAGGIHGYLVRFLSSEDSTFAHIAAWTIVQLLEAGFIQSSDDIIELLNDIVARDANNGEYEDGEGDVI-----LLSGRALHLIEQD................................................................................................................................................................................................ 547
18 -17.900[U] KOG1058 Vesicle coat complex COPI, beta subunit  ali follow..  10  22.SEAQLKEKFEKGGDKEREALKKLIYMIGEKTSQSMLMYVIRFCLP--SNEHTLKKVLLIFWECVPKTDSNGKLLHEMILVCDAYRKDLQHPNEFVRGSTLRFLCKL-------EPELLEPLMPAIRACLEHRHSYVRRNAVCAIFTIYKNFEFLIPDAPELVTEYLEQEQDASCKRNAFMMLARALDYLSGCIDQVGSFGDILQLVIV-ELIYKVCHNNPNEASRFIRCVYNLLQSSSPAVRYEAAGTL------------------VTLSNVPAAVKAAASAY-----------------------------------------------------------------------------------IDLIVKESDNNVKLIVLDRLVALRGSSSNEKILQGLVMDILRVLSSPGLEVRKKTLSLALDLVSSRNVED-------------------------------------------------------------MVMFLKKEINKTATES---------------NDENGKYRQELVKTLHAATIKFPDVASTIVPVLMEFLSDTNEKASSYVLQFVREAV-------------------------HKLPNLKNAILGALREGI--PFIQSPTIFMSAL--WILATYCEADGALDVLKLVKNSLGELPLVDSELSGQEEQKPEEQ------------QPEQQQKQKPKVTADGTYATQTALSSTVTTSKKNEKPPLRRFLLDG--FFLGASLATVLTKLAQQFTELNGAASERANRFRAECMLILSSIIHLCIVHQQVNEDDLDRMGATIKILAQGIPGLDEQYGDDCKKSLELMLGAKSISRLDVTTEKMASTTAAGYRSKDFVEIDKT 680
19 -17.400[D] COG5657 CAS/CSE protein involved in chromosome segregation  ali follow..  10  2..................................DDIPTLLARTLNPTTSKSAEEALKVW----------ELQDSSFALKLLNIVAE--DTVDINIKLAASLYFKNYIKK-IRISDEVAELIKREIINLMLKSTTIIQVQLGEVIGYIANFDFPDRDTLLPDLISKLSAVDMNTNIAVLS--------TAHAIFKRWRPLSDALFLEIKYVLDRFCEPFLALFVQTNNLLRNGPQDAESLNSLFQVILLECKLFYDLNCQDIPEFFE--------DHMSEFMTAFLNYFTYTNPSLEGDEGETNVLIKVKASICEIVELYTLR------EEVFTMLYDFVNVTWTLLTTLTPDEKYDGLVGKAMAFLTSVIRIRKH------------AEFFQQDQVLQQFIELVVLPNICLRESDEELFE------DDPLEYVRRDLEGSNSDSRARSAIVLVRGLLDHFDQKITSVVSTHINANLQQFSTNPSLEWNKKYVALQLFSAIAIKGQSTRLGVTSINLVVAFFENNIKPDLLQPAGVIHPMVLAEDIKYVQLNSQQLIDIFPTILRFLEMPSFVVYTYAAIALDQLLTVRHNHVHIFTSLNQLFLIVESASTPQKLAENDYLMKAVMRIISQEAILPSLLLQHLTKITEEVSKNPSNPLFESIGALIRSLSKSGPQTVSQLENALLPVFQNVLI----EDVTEFIPYVLQLLSQLVEASGNEPLPDFVVNLIQPCLSPALWDSKGNIPALVRLLRA--SNKFVEPVLGIFQKLISSKVNDHFGFDLLDRVFTVFNAN--ILAPYINHIFFLLLSRLKN.......................................................... 773
20 -16.900[U] KOG1062 Vesicle coat complex AP-1, gamma subunit  ali follow..  10  2.................................................NPFSSGTRLRDMIRAIRACKTAAEERAVVRKECADIRALINEDDPHDRHRNLAKLMFIHMLGYPTHFGQME-----CLKLIASPGFPEKRIGYLGLMLL-----DERQEVLMLVTNSLKQDSNQYVVGLALCALGMARDLAPEVERLIQFRDPNIRKKAALCSTRIIRKVPDL-AENFVNAAASLLKEKHHGVLITGVQLCYE----------------------------------------------------------------LCTINDEALEYFRTKCTEGLIKTLRDITNSAYQPEYDVAGITDPFLHIRLLRLLRVLGQGDADASDLMTDILAQVATKTESNKNAGNAVLYECVETIMAIEDTNSLRVLAINILGRFLSNRDNN-----------------------------------------------------------IRYVALNMLMKAITFDDQAVQRHRVTILECVKDPDASIRKRALELV--TLLVNENNVTQLTKELIDYLEISDEDFKEDLSAKICFIVEKF------SPEKLWYIDQMLKVLCEAGKFVKDDVWHALIVVISNASELHGYTVRALYKSVLTYSEQET--LVRVAVWCIGEYGDLLVNNVGMLGIED-----------------PITVTESDAVDVIEDAITRHNSDSTTKAMALVALLKLSSRFPSISERIKDIIVKQKGSLLLEMQQRAIEYNSIVDRHKNIRSSLVDRMPVLDEATFNVRRAGSFPASVSTMAKPSVSLQNGVEKLPVAPLVDLLDLDSDDIMAAPSPSGTDFLQDLLGVDLGSSSAQYGATQ.. 674
21 -16.800[OZ] COG5234 Beta-tubulin folding cofactor D  ali follow..  10  204.CESSWFKRSIFYKIGCLFSLSSFLKICPRNDCLQTVDVAFQFLNVAREDLVGQENSAKLLCKCYTRLDSNEEVHIYLEVIVDFLLSSVSDIDSFVRWSAAKGLAKI---ISRLPWNLAEQVIDAIIELMTENMFLNPIEAILFFAKLAGAKYSKCLHILPLIEVGLSYEVGQSIRDASCYFV-QTNLILCLLQTVLFDNEINVRRAATAALFEVIGRHASIGLSLISHINYVSVTDISNCYGDLCMKVAFPQFRSCVFQRLFTNLQHWDVKVQQLSAFSLRQLSIKY------------------PKELSIYLPPILDYLSVGNADFIFGYTIGLASIIGGFLS--ISFPFDINRIHDLLSHKNLLSLKKFSRQQQTKIILGILKGIQQIFANDRVDRAFFSEAFSVIIAIDLQEETIIKDISDAYSVLVKFDDMEETLEVLLDYIRKCSTSKEARIVYIILQNLPNISFRYQKKICKLLLDIYPQLHSIDYQAPVANALQNIIPFTYEKTESIEEFVKELLQVCSNYLTDTRGDVRKPAMKAISSLLKLSEDIVWCCISYIIRQTFDKIDSLRGLAYQALEQIRVHYLIRRCEALTNIINRISFRNNPNMDGEVLNEL----NISLLEIPNLRLQAFYGITVFTADGFGSDLAVKCFEFYLSYVYQL--EDSFKKSNSRYGKRDLLQLYIDILSSEDEIARYFPIMKSFTSLLAFQNVKGMSKAIFIVQRRALTCKSPGGLSAILELYRTLFLSKNELLRHHALKYTANLKVRYQAADTLLYAKSIGPNELNQKLLTLDFVPVSQNATFVKQLRNIIQ....................................................... 1097
22 -16.300[S] KOG2149 Uncharacterized conserved protein  ali follow..  8  1......MSRSKAPARKQQKKGIDFKKIKRK----------LGRKLPPPNNATNTEKAIILHEQSVAAERDGFATSK--GLTLLELKNRTGHPNAKVRKDALHGIKDLLKHHPAELLSNKYATTHKLRELITDDDKLVRDDFYTLLTGIFLACKEDINSSLMPYIFTAMTKSSIEVRLMAFKFFRLVLEFYSPTFKILENYKDVIHNNHFYIQDKKKLKVVLLGLADCLSLLPCDQSDNESKKKKEIVAVLINCFQDFLPLIHASQRINKESFDCIRHILRSIGYAIKFSIRRHTQRHTKWLPSPEENTLMIL-------------------DRDIASMLSKKLLGSFPLNHENNFSVENNGVLTEIFLEVSEWSHLPCDLSNRFLEFIENALLGKITRSNSLDKTLLALKLLLRVDRDRRDNLMQAFTITFNNCKPESSLKLACISVVKDLIIPNGDILYPNDPTVNNYQRA----NKLPSLLNQLGDKHHVSTKVVLQLLLDLARVGCLNASPTVSLPREVQEVALCFLYYIIDNFSSPMLKAIVSCCLLEPAVLYRIVEILQTAYRGGYIQI-TDHFSFFITLISRFKVV------PEKLNSAIECDERKANCGTFKTLTNLVCSYLS--EMGDSSLVLQILEKVFVEQIILKPALDNGCAILRMICALDSKPTRTTLSEFLPGYLIDIVNCIPEDKERSYLYMTEQVLKRMRSMVSENVKALESVQDRESGRDSLNLIQ--CIVSVILLMHNDV---------KVRKIISSSKSEIDLILQNVYTLQSSRSTSLTVEGKHMMKAAERLSIASNSLLA....................................................... 863
23 -16.300[U] KOG1078 Vesicle coat complex COPI, gamma subunit  ali follow..  10  28.AVLQEARVFNDPQVDPRRCSQVITKLQGESFTKVEATEVFFSVTKLFQSKDTGLRRMVYL--IIKELSPSSDEVII---VTSSLMKDMNSKIDMYRANAIRVLCRI------IDGTLLTQIERYLKQAIVDKNPVVSSAALVSGLHLLKTNPEIVKRWSNEVQEGI-QSRSALVQFHALALL-IQRPFYEFLESCLRHKAEMVILEAARAITELDGVTSRE-LTPAITVLQLFLSSPRPVLRFAAVRTLNK--VTNCNIDMESLISDQNRSIATLAITTLLKTGNESSVER--------------------LMKQITNFMSDIADEFKIVVVDAIRSLCVKFPL------------KYRSLMTFLSNILR--EEGGFEYKRAIVDSIVTIIRDPDAKESGLLHLCEFIEDC--EFTYLSTQILHFLGIEGPNTSDPSKYIRYIYNRVHLENAT---------------------------------------------VRAAAVSTLAKFGFMVESLKPRITVLLKRCIYDSDDEVRDRATLYLSEP....................................................................................................................................................................................................................................................................................................................................... 523
24 -16.200[D] COG5537 Cohesin  ali follow..  12  86....EFFLKLLDIDMPLEQLSQHYFEDYKSNS-ADFMLTFINFALVASGCQPFVTRFQLFLVEFISKVYVEDAGDSFMETTKAWIFTMTTSPWMLVRHTATTICCDIMRCLCLIVNKLSEKSNQVLFSRIHDIRASIRIVCVTALYDCQLLPTYLINRNLIRHSGWGLSDAESQIRKISLKIIDYLDRFSLRIVEICRYDIDSVRSVAL-KTCEKLMEKISLNGKCINIVSS--IFDGKPQNRISTMRILVAHTNERYANYCEAKTATISLSKLLFILEQGFESWFRDSSDHIFSRVKDDDKFVYQSQENNFYDADFIREYDMNNHRTNSQLLASWEDVAKLLLYDRFDAKDTNSVLNPCIPSNAVIEFSSIYEDEVVNQQQAMLRNLPLLLQKYRESCVSSYFFIKCVEQIPDEKREFHKDFSKLYKEILDIFNSTTVNFAVNKVVQEDILFAIDNVYNDLAESLHEQLNAYIQRKKINKKNQLNGNDETQNLVLALNKFGCFAKEMVCLRDVNDWNIKLSEKLCEICSLEVGPIVCYSSLKVLFLLLLSDRDRNCIFTNIFLKAAKVAKQKNGNSFLSKVFITITMLTLFLGSKANNWD--------INFSDDDLKLMNEEEIMEQIET.................................................................................................................................................................................................................................................... 859
25 -16.200[T] KOG4500 Rho/Rac GTPase guanine nucleotide exchange factor smgGDS/Vimar  ali follow..  9  1....................................MATEIDDLIEKLKTTSVSPANTTNLLCEISATKDPKLFDK--HELAECFLGLTKCDDTNVRKEAAKCIAEITKSEVQRKKFTKRNIIAAFLECLRDGSMELPIQICRALGNICYLNDEARDLILEAVLLRLLDITTIEDVANAAQFIKVRGGLLSNYLLGGEGLAKRAMELGVMKKLQGIIDIGASNVEQHEDLLLNTLPLLSILTENVSDLNFD----SSLNIQLSRILAASTNPDLAEMCLELLHYQAE-----------SDEVKLILAKDGLC--ETIYNLLEKYKTLASTSEARALMKLACELIVLILTGDDSMHYLYTTPLLKNMVDW---LDSTDIDLLTTGVLALGNFARTDSVEQQTMNKLLEVLAKNNGVKDDLQHALLSALRNL---------------------------------VIPKPNKNAVIQAGLVQTILPMLEIHQPPVVFKLLGTLRMTVDGQEKLALELLKNKTLIEQLVHWSKSSDYAGVTGESLRLMAWLI------HAYLSKIAYALPRKGDAPAEQIADKIPLTQDYDRSSLSEFLANEGTVEAMVS-MLTAQHLVMQNEALIALCILSLQDELVKCEVGKKLAELISKSSDTMTKEIVENLQNCVNLLKSSEQLVAHLEQHNINELLKSIPILTEYCT................................................................................................................................................................................ 633
26 -16.000[O] KOG4413 26S proteasome regulatory complex, subunit PSMD5  ali follow..  9  2................................................EDVNQLFDAAFEFAHYPGAQNETSVKEFLDRFPLPVIFNALQTDPPGFENTLVTCLERLFKTKYG--ASLIPQYMPVLQVGLKADSAVVKSLACKTVLCLLEDCDTNDVSSVQLVV---------------------NNGIYPLLLDYIINSDDEVANAASETIKSLARFPDAMSVTNDPTHLRNLAARCSSLARVRVLSLIV---------------------------------------------------------------------------------------------KLFSISRLVASEVKKSGLLDLLEAEMK--GTKDTLVILNVLELYYELMEVEHSSEFVPQ-------------TSLIQLLCSIISG---------------------------------------------------------TSTGPYEKLRAMMISGRLLSKENIYKVVEEASVKALISAILESVEMNDTDAQEAAIDALGQMGLVLSTSPPAARHVVASAFDRNAHGKQLAALHALANIAGETRPKSNRIVDGKAEESLLFLSVLQQSSEIRLAGYRTLTALVLVEILAKEEIINIVT----DATTETAKIAMEARYNCCKAIHEAFLCSNFVDDPRRLKTGDKLQEAVRS.................................................................................................................................................................................. 498
27 -15.800[YU] KOG1992 Nuclear export receptor CSE1/CAS (importin beta superfamily)  ali follow..  9  10.TLTEYLKKTLDPDPAIRRPAEKLESVEGNQNYPLLLLTLLE-----------------------------------------------KSQDNVIKVCASVTFKNYIKR-NKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGREDFPQKPDLLTEMVNRFQSGDFHVINGVLR--------TAHSLFKRYRHESNELWTEIKLVLDAFALPLTNLFKATIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFWE----GNMETWMNNFHTLLTLDNKLLQTDDEEEAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAI----------WNLLVTTGQEVKYDLLVSNAIQFLASV-----------RPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEEAFE------DNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNPSVNWKHKDAAIYLVTSLASKAQTQKHGITQANELTEFFVNHILPDLKSANVNLKADGIKYIMIFRQVPKEHLLVSIPLLINHLQAGSIVVHTYAAHALERLFTMRGPNNATLFTAAEIAPFV------------------------------EILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQKLLAVSK--NPSKPHFNHYMFEAICLSIRITCKANNFEEALFLVFTEILQNDVQEFIPYVFQVMSLLLETHKNDIPSSYMALFHLLQPVLWERTGNIPALVRLLQAFLERGSNT-SAAADKIPGLLGVFQKLIASKAND.................................................. 744
28 -14.800[U] KOG1077 Vesicle coat complex AP-2, alpha subunit  ali follow..  10  3.GLAVFISDIRNCKSKENKELANIRSKFKGDK--KYVCKLLFIFLLGHDIDFGHMEAVNLLSSYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGS--RDMAESFSNEIPKLLVSG--DTMDVVKQSAALCLLRLSSPDIIPGGEWTSRIIHLL-NDQHMGVVTAATS-----------LIDALVKRNPDEYKGCVNLA---------------VSRLSRIVTASYTDLQDYTYYFVPAPWLS------VKLLRLLQNYNPVTEEAGVRARLNETLET----------------------------------------------------------------------ILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNLRYLLESMCHL----------------------------------ATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGN--------AEEIVQEMLN--LETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVI-------------------------NREEVQGYAAKTVFEAL--------------------QAPACHENMVKVGGYILGEFGNLIAGDSRSAPLV---QFKLLHSKYHLCSPMTRALLLSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQ-----------------------RASEYLQLSIVASTDVLATVLEEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPAPLTSAAQNNALVNNSHSKLNNSNANTDLLGLSTPPSNNIGSGSNSNSTL.. 677
29 -14.700[O] COG5656 Importin, protein involved in nuclear import  ali follow..  9  5.......................................................................................................................QAILSCIEQTM-VADAKIIKEAEQQLFEF-----QKQPGFTSFLLNIVSDDNALNVRLSSAIYL-------KNKIHR-ADEKLSIKERLIETLVK---------------------NCENNHIRPILTETINGILVGQEDWDLAPIIKNLLSSGDASYIYPGLLLLFQ-----------------------------LCKAHRWDMVGSRDYIDSVIEELFPIVEGIASNIGSQTDYRSNE-ILYLILKSFKYACLNN----------LPQYFSQPERIMSWVQLHLYLCSKPLPVEVMELDPADRSLDKRVKVNKWGFGNLNRFLQRYNKITKAITKEFIDYIFNTIVPIILREFFKDIEAWGNNSLWLSDSSLYFLISFLEKCVTIDQLYPLIEPHLQIIFENVIFPCLCANEQSIDAASADFIFLIGSKRPEKLNNILPFINDIFTRFDANKEEGALRTL---NLFSFIDEPSVLENIFGHFIVPLLSQDKYMFLVARSLETIAL--YSEEFKDMNILSQLFELTYTNFLNSNV-VQIEAADAIKCLIVSNPQIHPAVSAHVPGMMEKLLKLSKIFEIDILSEVMEALVERFSDELSPLRIAQALVENPSETYSASDQEQEIQASGLLQTMTTMVMSMNKVPLIESLAPVFVVLHAQISFITEAVDLLDALTISSHLLYNQIAPPIWELLHDILDSFQ....................................................... 686
30 -14.400[O] KOG2062 26S proteasome regulatory complex, subunit RPN2/PSMD1  ali follow..  8  1..MTMVYSDNTSIITSAGGLMALLDEQERE-------------------QVHALLKIYEFIDQLWPEISDD----------VTKIEVMYEDHSFPERELAALVVSKVYYYLGEYDEALLFALSSGPKFLHDKNSDYKETLIFKCIDMFKNPKADPLDERLSGVVEGIFQKCYAKNEWRHVLGIAIEAHRLDIIEYILNADKETDLKPYVLELAMTVVLDIEFR-NRLLRLLLSSFLTETEPDYFSVGKCVVHLNDASVAAKLLMKLSSQNDDKSLLTAYQLAFDLEDSAPQEFLNSVMDLLPSPSVANSEEDA-----------NADSKKEDSSPCGYIIRILSGEQTVKYDREFLYAHNNTDMLILNRTKDSLEARNSVFHNAVTFANAFMNFGTSSDSFFRDNLSWLSKANNWSKFTATAALGVIH--RGYYNQAMNILRPYLPEEDAPSSSTYSEGGAFYAMGLIHANHGRGVTEYLREQLKHTEDEIVQYGLLLGIVKTILFNDNAVAGSAAGISAAIDEMLQYAHETQHEKIIRGLGIGIALIVYGRQQEADGIIKELN---NDLDPTLRYAGMFAT-------ALAYCGTSNSKIVRDVLHISVSDVNDDVRRAAVCALGFICFKDPNALISTVELLV-------DSYNPHVRYGSAIALGIACANSGSNA---------ALDLLSRLVEDATDFVRQGAMIAQAMILTQHNDQSKVSGIRKHFEQVINEKHEDALAKLGATLAQGIIDAGGRNVTIALTHFMSLIGLDKNLNAPKFSFISNVRPKLFAYPPKSVQPTAKTVQKVETAVLSTTVKAQARAKRAEREKASKGSNDDEMKIDKKTTEEKEATPMEMDEEKSQDISINGNS. 874
31 -14.400[O] COG5116 26S proteasome regulatory complex component  ali follow..  8  1..MTMVYSDNTSIITSAGGLMALLDEQERE-------------------QVHALLKIYEFIDQLWPEISDD----------VTKIEVMYEDHSFPERELAALVVSKVYYYLGEYDEALLFALSSGPKFLHDKNSDYKETLIFKCIDMFKNPKADPLDERLSGVVEGIFQKCYAKNEWRHVLGIAIEAHRLDIIEYILNADKETDLKPYVLELAMTVVLDIEFR-NRLLRLLLSSFLTETEPDYFSVGKCVVHLNDASVAAKLLMKLSSQNDDKSLLTAYQLAFDLEDSAPQEFLNSVMDLLPSPSVANSEEDA-----------NADSKKEDSSPCGYIIRILSGEQTVKYDREFLYAHNNTDMLILNRTKDSLEARNSVFHNAVTFANAFMNFGTSSDSFFRDNLSWLSKANNWSKFTATAALGVIH--RGYYNQAMNILRPYLPEEDAPSSSTYSEGGAFYAMGLIHANHGRGVTEYLREQLKHTEDEIVQYGLLLGIVKTILFNDNAVAGSAAGISAAIDEMLQYAHETQHEKIIRGLGIGIALIVYGRQQEADGIIKELN---NDLDPTLRYAGMFAT-------ALAYCGTSNSKIVRDVLHISVSDVNDDVRRAAVCALGFICFKDPNALISTVELLV-------DSYNPHVRYGSAIALGIACANSGSNA---------ALDLLSRLVEDATDFVRQGAMIAQAMILTQHNDQSKVSGIRKHFEQVINEKHEDALAKLGATLAQGIIDAGGRNVTIALTHFMSLIGLDKNLNAPKFSFISNVRPKLFAYPPKSVQPTAKTVQKVETAVLSTTVKAQARAKRAEREKASKGSNDDEMKIDKKTTEEKEATPMEMDEEKSQDISINGNS. 874
32 -13.700[U] KOG2081 Nuclear transport regulator  ali follow..  10  2.............................DTYSVDVVYQAISALFQGNNPKEQEK-----ANKWLQDFQKSIYSWTIADELLH------QKRDLHANYFAAQTMNKIQNSFSELPPHTHESLRDSLITHIEQTDNVIVTQLSLAVADLALLMASWREPINDLLVTLAPHQCAIWPLLEVLKVLP------EEIDSRYLRLGANRREEVHKQLDA--------SAECVLKFLCMCLQREDLDQQRVWNAALYSAWLVIHAFPVSHVYNNTSGKLHDNATECVCALLSCINTRQDGASDPESSFEAQLFGAVCMLETPYHLSVAHEDTDKTINYCRIFTSLCDAFFYDLLADAQKPHYSLK--GLDLVLLCVGHFDYEVAEITFHLWYKLSEDLFQRNEDKL---------------TVLFRPHIERLISALFRHSQMESDHDGLIEENNNFFDFRRKVSDLIKDVAFIVGSGACFKQMFHILQAPETTWESTEAALFIMQNVAKNILP-----DENEVIPKVVE-AILNMSEQTHIAVRYTAILLIGELC--HPESLEAVLNFLLYALQ-QKNGLAPAAAIALTSIC-----QKMVCHISGLVEIARSLDSFQINNDVAIGLLKGISLIL--TRLPREQLQPALREIV-TPQKGERTDPVYWIDRACAIIRHTNPDVPDNVEHPTVAILNDAWQL---------------ISRVMDKYQSDLRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHHSCFLYVGSILVDEFAKSSECIGGLLEMLQAFIEPTSLDHREANSSVMKFFINLLVWGRSNNHSRNTECRPLVVE....................................... 814
33 -13.600[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  10  1....................................................................................................MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASSTLDDRRNAVRALKSLSKKYRLEGIQAMEHLIHVLQTDSDSEIIGYALDILYKQQENVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPLVSPMGVSRLMDLLADSREVIRNDGVLLLQA---ENAFERLLDIISEEGNSDGGIVVEDCLILLQNLLKN-------------------------------NNSNQNFFKEGSYIQRMKPWFEVGDENSGWSAQKVTNLHLMLQLVRVL---SCQKAMFQCGLLQQLCTILMATGVPADILTETINTVSEVIRGCQVNQDYFASV----------------------------------------NAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQG------EIVSTLLPSTIDATGNSVSAGQLLCGGLF---TDSLSNWCAAVALAHALQENATQKEQLLRV-----------QLATSIGNPPVSLLQQCTNILSQGSKIQTRVGLLMLLVTHFLHNSANVPFLTGQIAENLGEEEQLVQGLCALLL-SIYFNDNSLESYMKEKLKQLIE-------------KRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMI 760
34 -13.600[U] COG5064 Karyopherin (importin) alpha  ali follow..  9  20........KADELRRQREEQQIEIRKQKREESLNKREFPKLTADV-MSDDIELQLGAVTKFRKYLSKETHPPIDQVIACGVVDRFVQFLESEHHLLQFEAAWALTNIASGTTDQTRIVVDSAVPRFIQLLSSPEKDVREQVVWALGNIAGDSSACRDYVLGNLLNILQSASDVSMLRNATWTLSTISVAVPILAKLLYSEDVEIIVDACWAISYLSDKIGAILDVGCAPRLVELLSSPSVNIQTPALRSVGN---CGALNAFPSLLSHQKENIRKEACWTISNITAGNTQQIQAIIESN-------------LIPPLVHLLSYADYKTKKEACWAISNATS-VIKPLCDMLNGSDNKIIQVALDAIENILKVGEMDRTMDLENINQYAVYVEEAGGMDNDIYLKAYSIIEKYFSDEDAVEDLAPE.................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 512
35 -13.600[TW] KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins  ali follow..  10  353.............................................................................LERAVSMLEA--DHMPPSRISAAATFIQHECFQKSEARKRVNQL-ILKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNKLEVVPRLLQVLKQTRDLETKKQITDHT----------LRSRNGWPGAVAHAC----------------PSTLGGQGGRITRSGVRDQPDQHGLL-------------------NLSSNDKLKNLMIT----------------------------------------------EALLTLTENIIIPFSGWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGADGRKAMRR------------DGLIDSLVHYVRGTIADYQPDDKATENCVCILHNLSYQLEAELPEKYSQNIYIQNRNIQTDNNKSIGCFGSRSRKVKEQYQDVPMPEEKSNPKGVEWIVIRMYLSLIAKSVRNYTQEASL-GALQNLTAGSGPMPTSVAQTVVQKESGL-------------QHTRKMLHVGDPSVKKTAISLLRNL--SRNLSLQNEIAKETLPDLVSIIPDDLLIETTASACYTLNNIIQNSDLLNTGGIQKIMAISAGDAYASNKASKAASVLLYSLW--AHTELHHAYKKA................................................................................................................................................................................................ 860
36 -13.300[U] KOG0166 Karyopherin (importin) alpha  ali follow..  14  173.IFIELLSSEFEDVQ--EQAVWALGNIAGDSTLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRG-KSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSLLHLLSSPKESIKKEACWTISIDANIFPALISILQTAEFRTRKEAAWAITNSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEEAYGLDKIEFLQSHENQEIYQKAFDLI.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 500
37 -13.000[TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family  ali follow..  8  529..........................................................................IPYHELFCALLKNPDIISSSVKQSLLLDGFFRWSQHCSNFNKESMLSLREFIMKALASTSRCLRVVAAKVLPIFIKGPNNLDKESKALIFNTLKAVENTAILETVILSWIELHFVLLEVISSVINSGIFYQGIGLSALQQIAISEGDFLIRTQAYTLPFLVLTKNKALIVRIAELSQSDVATLCLTNMHKILASLLTTDHPNLEESVMLLLSLATSDFEKVDLTS-------SDPISITVELLQLYQNDVPHEKIENALRKVAMILAEFSNILNDLKGKTSINEKIKTIVGIEKMLSLCGGAVKLGLPQILSNLQSAFQNEHLRFYAIKAWFSLILAT--KEPEYSSIAGLSLVILPPLFPYLEPQEAELVIQIFDFISSDTHKCSLKAKEIFCSLQNEDFYSELQSIIKCLTNENEPVCYLGLQKLELFFQAKVDELHDNEVLDQLLRCLLCVKYASTNMQISYLAAKNLGELGAIDPSMQSQLIPAFLVTTDTKAQGFLAYALQEFLKLGGFKSAVINKKKGLTVVTEHWMSLPDLSKRVLIPFLTS-SLKLM---EYAHSQNAEKIFGICSKVVKDQEVNIPCFL-LVLNVILTESELEVNKVIEEFQLVINQPGPDGLNSVGQQRYTSFVDVFFKIVDYLNRSAIARKENRYMSVEDATSRESSISKVESFLSRFTLGIVSLNCGFHARALFYWEQPYAALESDYRVLQEIYAGIDDPDEIEAVSLNFHDYSFDQQLLLHENSGTWDSALSCYEIIIQKDPENKKAKIGLLNSMLQSGHYESLVLSLDSFIINDNH. 1513
38 -12.700[YU] KOG2022 Nuclear transport receptor LGL2 (importin beta superfamily)  ali follow..  9  2.............................DGNEIAHAKKLVYDLYSGSLSPSAIAATEKELQKAQRS-----------QQGWNIGLFMLQSKDVYEQFFGALTLMKINTQLETLSDKDLVQLFVQLLQKLDGLPALVERKVICTLASLTIKYELEKEEASLKVIYCLFCNKLEFFNADMNAASPASSRNAQLTASYINELLLELEDALFNNVFRPCSNIIVSVLVFIFTNYSLDLKEKNVAALEEALNCM-IAISSSVLPAFTECMDLTVNCIALDEVSEKAMNCLADLLANYSNFITQPTIERLWTILTGPWGETHLQQELEDPDSGEENDYSFLNIVIGFAEAMLPQIIDHIQEEKSIRLLYILASLLSF--------------------VEEKVSWRTLEFWTTLIEDFSMSKAATDPSKDEIFKQIAFSVVEPEQWNSWPSSSRDSFNSYRRDLGDLLESFGERLYAMYITTIENFFSDGTGSPQSLEVSFYCLCCILEYDTNDSD--TLDAWLTRLFETSFAIKASAQNPQLLKTCSQLLSSCS--HPQYLNISLPVLFDALHISETSIQMTVSRSIHTLCTTCASHLLTEIDG--FMAVVEELTPKLVPSVLEKIYSSVGYVT--QRIEDIELRISYLMRLLNCILAQENVLKSCLQSVAGVALSQSPIGESEFQAKLISFLTHSESMALQYSDVVGLIPIVTTIQYFCDRFTEFTLGSAILTCPYGQTDIIDKVLIDMCSSIQNSVVIMNNIDITVELYHFFSIIKHPSFLETMYPDFTQLILNRAINLLGKPERLLESAAGQFIISFITSEKSDLLNTHTD.............................................. 885
39 -12.500[S] KOG4646 Uncharacterized conserved protein, contains ARM repeats  ali follow..  9  17.................................................................................LQALVTEFETQSQDAKEQVLANLANFAYDPSNYEYLRQLQVLDLFLDSLSEENETLVEFAIGGLCNLCPDRANKHAGGVPLIINCL-SSPNEETVLSAITTL-TATPVVQCMLRFSLSASARLRNLALEDFCSPRQVAEARSRQAHSALGIPLPRSVAPRQR........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 198
40 -12.400[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  12  424.........................ALREASSAIDVLGETLVAEAYCKTREDALLALSKKLME-MPVGTPKEDLKNTLRASVFLVRRAIKDIVTSVFQASLKLLKMIITQYKLETAHCVERTIPVLLTRTGDSSARLRVTAANFIQEMALFKEVKSLQIISYLVQPLKANSSVHLAMSQMGLLA-------------------------RLLKDLGTGSSGFTIDNVMKFSVSALEHRVYEVRETAVRIILDMY-RQHQASILEYLPPDDSNTRRNILYKTIFEGFAK........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 670
41 -12.200[S] COG5543 Uncharacterized conserved protein  ali follow..  9  155.DSLKHALHWDRHAKVVCTAIQLLVKVTGAEAVFAFQPDFFEQSLKLLKDYSYAQAISSTILTVLTLRFKSEVETKWMNIWCPIILYEFYGNDRQVQAGMSSLIPSLLGVSPGITVKFLSRLHAFVKTLFKHPDIKIQLACFRLIPNVSSPLSFEDFDCLESNIEFSFNVLDPDSRQILLKSM-------QDFFIRLRASCHSIQVLVSLSFLDTLISF-VIIDRDLSRLMIDRLKDPYDDIRNLCLKILLS-------------------SLPGFISDSDAYFLFNHGLELLNAVRSHE------CDGGAKTIYLCNHFMEKSVPGSVLANTKVINRLKSNIEHAKTSLLEAAVNCPLQGYLIQLTYIFQSLSPTIKNDNESWKNIVMELI-------------------------KASETIWGLIKDVLCDDSPEGNLPDGEGEGGIVSNLEDTPAQLILS-RSLKETSSLLTVLLTKCLSLFDEEFTPFTLNYYGELMMTWLWEIR--ECNKHEISELPDPWLHKNLSVIQEKSSFITRRSGGIPLSIREQLIEQTVISLISIAKQPVEQ-QVHAMNTLKTIF-----------TEHRLSSVSVEYLE----PAIALSIEGFSHELWPIRNCSVMLFTALINRAFGSKKPKDAV-GLSTKMFFSKFPT--------LHDYLLRELEVSVASLSSNDQPSTGLYP--ILNMFSRLQYAQPYGNENEWTGLSQ-----------FEPLIFKCTASRICKVREIASLSLTCL-----DCSKMTTFIVSQLKGV-------AGLQQNEIHGKLLTIRAVLSCFFSKLTLQQVQE.......................................... 1043
42 -12.200[R] KOG1243 Protein kinase  ali follow..  12  273VDTLLFLEEIQKDKAEKNRFFSGLTTHLDNFPDNVCRHKILPQLITAYEYGDAGSAVLAPMFKLGKLLDEVE----YQKRIVPCVVKLFASTDRVTRSRLLQQLDLFIAHLQP--QVVNDQIFPQVAHGFLDTNATIREQTVKSIIHLAPNYNNLNVEVLRHFARLQARDDQGGIRTNTTVCLGRQRVLVSAFIRAMRDPFPPARVAGVLALAATQQYFLLSEVANRVPSLCSLTVDPEKTVRDPAFKTI-------------GFLGKLEKVSEDPSLRETMEA............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 552
43 -12.100[YU] COG5101 Importin beta-related nuclear transport receptor  ali follow..  8  15.LLDQVVSTFYQGSGVQQKQAQEILTKFQDNP------QKADQILQFSTNPQSKFIALSILDKLITR--PNDHRIGIRNFVVGMIISMCQDTQKNLINKSDLTLVQILKQ-----PQNWPEFIPELIGSSSSSVNVCEN-NMIVLKLLSEEVFDFSAE--------MTQAKALHLKNSMSKEFEQIFKLCFQVLE--QGSSSSLIVATLESLLR--IPYRYIYETNILELLSTKF--TSPDTRAITLKCLTE---------SNLKIPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLKATYANANGNDQSFLQDLAMFLTTARNRALLESDESLRELLLNAHQYLIQLSKIEERELFKTTLDYWHNLVADLYEVQRLPATEMSPLIQLSVGSQAISTGSGALNPEYMKRFPLKKHIYEEICSQLRLVIIENMVRPEEVLVVENDEGEIVREFVKESDTIQHLNVIDTEEIMISKLARQIDGSEWSWHNINTLSWAIGSISGTMSEDTEKRFVVTVIKDLLDLTVKKRGKDNKAVVASDIMYVVGQYP--HWNFLRTVILKLFEFMHETHEGVQDMACDTFIKIVQKCKYHFVIQQPRQTIIRDIQKTTADLQPQQVHTFYKACGIII--SEERSVAERNRLLSDLMNPTLLLDSETVKIIANIIKTNVAVCTSMGADFYPQLGHIYYNMLQLYRAVSSMISAATKTPKVRGLRTIKKELKLVETYISKARNLDDVVKVLVEPLLNAVLEDYMNNVPDARDAEVLNCMTTVKVGHMIPQGVILILQSVFECTLDMINKDFTEYPEHRVEFYKLLKVINEK...................................................... 869
44 -11.900[T] COG5635 Predicted NTPase (NACHT family)  ali follow..  9  375IDLSKIKTLLYSSADSTPKLIPQLHETAVRDNVFQEIIKTDPDVLLQTDIPTDSELRATIVANLLMQYEEEKKHSGLAEQLKVYICD--SSKKEDTRRIAIDIAIE-------------SELQGDLAKLTLCPSISIRVNAARAISSIGDQ--STRLKLKSLALNVLPEDEQDELKAYALKALWPRQLTAEELFQALTPSKRINLLGMHRYFLESEL-VPQLDSEDLVIALDWLKTQGVRCFGHPFEELGDAI--------LLKAWEHVNVPGVLEGFTQVALLQWKEHQKLISHSPSLQAQFQESLLGNNQKRYALIENL--------VESIAEKDEDEDFYFLTSSMTEPIISSNDVDWMLEKL-------DSNHEKIQRAWAKIIEEVFDRRD------TKQISEIIKATQNNSILSDVFSYYFTPI-----------ELDSEEVTQLRDHYLKMKNSWNKPDLLDPPPKERVIDCLEQLESGDLSAWWRLNREMTLLPQ-LTQLPGWKEAEQATKKRIIQGAIQYIQQQTNIDYSYGCKALQLIL-FSTDIWKRWTPIILSVPNSFIDSNPRKNCRKLVSLSYHHSPDEFLTTLLKLIDKENQDVIDRLEMCWDEKLENNLTEKVKDSQLKPNVFRKLLEKLIEQGAVQAKDIALSTIRNYTNSEFDSERQKALFAIKALINVIWEKITADVQFGFDLTEKQIADLYAWLVWQYPHYEDPDHRNEVMAYIVSPRDNIA-FFRNNSLSQLRDKGTIEACAELERLIQELP-RETWRPFKPDKLLEFLII-PEPSNLDLSNQLSTIDKRTEKMEDEPKIINN--------------------DSTINAPVGTSGVTSNNVTCSSPEKQKRFNW 1271
45 -11.400[O] KOG2005 26S proteasome regulatory complex, subunit RPN1/PSMD2  ali follow..  12  37............................................................................................................EDLSEEDLELKQNL-ELYVERVQDPNPELQKAALESMRQEIRASTSSMTSVPKPL-----------------KFLRPHYGTLKAFHETMADSDLKKYLSDILSVLALTMSADGERESLRFRLIGTEGSWGHEYVRNLAGEIAQEY--EASIDDLMELVQQIAFHMKHNAETEAVDLLMDVEDLDLLLEHVDKTNFKRT----CNYLTSAARYLPGPDDMLVLDISYMIYMKFEEYPNALQIALFLDNTQYVKQVFTSCTDLLKKKQFCYMIARHGITFELDDEMVADDDDREALQDIVNNTK--LSEGYLTLARDIEVMEAKTPEDIYKAHLLDGRASSGASVDSARQNLAATFVNAFVNAGFGQDKLMTVPSDSTTGSSGN-------------LFKNKEHGKTSAAASLGMIQSQLDKYFHSNDNPIIAGALLGVGIVNCGIKNDCDPALALLGDYIDKEDSSVRIGAIMGL-------GISYAGSQNDQVLIRNKLSILNDAKAPLDVIAFASLS-MIYVGSCNEEVAQSIIFALMDRSEAELGDALTRFLPLGLGLLYLGKQESVEATAEVSKTFNEKIRKYCDMTLLSCAVLKVQDLLAQCGEHLEKGDIHQGPAVLGLAMVAMSEELGVDMEIRSLERMLQYGEQNIRRAVPLALG-LLCISNPKVTVMDTLSRLSHDTDSEVAMSAIISLGLIARIAGMLRNLSSYYYKD.................................................. 739
46 -11.200[R] KOG1877 Putative transmembrane protein cmp44E  ali follow..  7  35..................................KRYKKLIAEIFPRNQEEGINDRKIGKLCEYAAKNAVR------FFQISDSLEHRCYKELRNENFHAMCIYRRLLVTCKEQIPLFSSGFLRTVQALLQTRQDEMQIVGCQSLFEFVINQLCQLGLEGGD------DDRSRSLRAAGLQALSAMIWLMGEYSHIPSEFDNVLLGFRVPIYSDLLSFIEINWFVVSNNRQSEKHSVGDKVVSAVLENYG-------------PKILTNANDSGRKWVDEVLKNEGHVAYEDSLINVPSWRTVVNDKGQRTFLLSMLIKHLDHKSVLKHPSMQLNILEVTSSLSETAKVEHSATIVSAISDIMRHLRKCMHSSLDEANLGSVAVDKCLVQLTKKAFPEALFHQLLQAMVHPDHKTRIGAHRIFSVVLVPTSVCPRPSSTTTDLKKGMGLPRSLSRTASVFSSSAALFEKLKKDKFSSMLTSDHSQNGMPEEERGSSTGEILDRLKSSYRQAYSTWNQPLTSVVDNSVDLLNSELNGTLEFYIYDVVHIRLSSHQIGLLLSSIWAQSISPANTPDNYEAIANTYSLVLLF--SRVKNSSHDALIRSFQMAL-----SLRDISLMEGGPLPPSRRRSLFTLAASMVL--FSSKAFNLFSLADFTKVTLQG-AYGCEKDDASALDTLSNI-GTLVYEIVKSLEDMCNSEMDKMREQLLTEFMPDRFLEDTHKTYQIDSGDVKPRKEDAEDQEFGDGTETVTKNNHVTFSEIPDLLTVNQILESETTRQVGRISFHTAADASYKELHCENLLMGKQQKISSLLNSQLRHESSVNCSPRQHDEEIKIASFHPMINSAFHTGVEVPLLSKEFDMKSPRTP. 925
47 -11.100[S] KOG4262 Uncharacterized conserved protein  ali follow..  8  2..LHQTFNGIWQ-----------LHIRTSRRFLQCRLLPEMERKISFLASSVKFGNQKRYQDWFQDKYFATPESHSLRSDLIRFIINVIHPTNDMLCSDIIAIIGWLISSC---------------------TNPIASANAKLSL--LFFDPAKDNIMNIEPGILVMYH--------SIRNHPFVSSTLLDFLCRITKNFFVKHEDKIRIGVYNSLKLILEKQVIPNLQPL------ESPKLDRELRNLIRDNFREFLSPPANHGQLLFTSLHPVQGHILKKES--DQRILHCENMDLHETGLINIKKPKVELAEAIAESFDAFVTKRNSYTWEAFLKDFRPLPASAFEEFQLNYVISN--TVLILRETLPQQNIFSE-----------SKTEEKHLAKSISYPLYGLFRFLYENDEKSKKPFQTLLSEICEGIPEIGYLLLYFMKIYCKLQTRKNSQQSYQFKTTIYRQICDAADEKIGNCLLRDLDLLEKENTNIFLLLPDIYREFKSIATNNTDLLRITLRCIDAKNVRD-----------------ILYSIAQGKLTIF----QDGLIDCIRQSLE--YEQFCLWQIVQAHDVPLRCIQDILPELEAGSHPE----ALSHFLLLL-KNEEPTNEIIRLMLSR--ESKSKGDPFVTSALRFWCQRYE-------------------------------------EKLSEIIASLLTSKYPSSSPNKRKRPPKGISVSTSTPSADQVLNHLEHYRRSCRHGTGTGLYVHDMMQRALQSAYSHSNDSTKKQFCDLFALAAEEDTTVGRRGGSGRGRKQPGSKKDVNNHGTSKKNPEMVKTIYSSDDNSSEEDWSKSKILQTAKRRKKANNDSD. 757
48 -11.000[ODR] KOG4151 Myosin assembly protein/sexual cycle protein and related proteins  ali follow..  11  416.......................................................KLSCFLITMLQGPVDIGINLITNDQLTPIMLEMAASQDHLMQGIAAELIVATVSK-HERAINMLKVGIPVLRALYDSEDPTVKVRALVGLCKIDISKATMKEEAVISLAKTCKKKYSVDIRRYACEGLS-DSLLLKALVLLAKKAGALCVYTLATIYANLSNAFEKPKVDEEMVKLAQ--KDTEEYVEKRVRALV--------EEGAVPACVAVSKTESKNALELIARS---------------------------------------------------------------------------------LLAFAEYEDLRGRIIAEGGTVLCLRLTKEASGEGKIK--AGHAIAKLGAKADPMISFPGQRAYEV-------------------------------------------------------------------VKPLCDLLHPDVEGKANYDSLLTLTN------LASVSDSIRGRILKEKAIPKIEE------------FWFMTDHEHLRAAAAELLLNLLF---YEETVAPGTDRLKLWVLYSAEVEEERLSRASAAGFAILIMDEIKSWPEVFKDIA------MHEDAETQRRGLMGIANIMHSSNKLCSEIVSSEVFRVLVAVTKLGTINQERA---GSTEQAKRGLEAAEKFGLIKATDREIYERENQMSTIQ..................................................................................................................................... 960
49 -11.000[S] KOG2969 Uncharacterized conserved protein  ali follow..  9  3.................................YAAFQHNVSGFLVNAKQTD-----FNCLNDF----------------------KPLKWQTCAVYTSLFVCRSSCCRSEQEMEVE-ASNLLRLIKQLLLEKAYD---GVRMLFQSAQESEKNTR-DLYHDVCLENISDEVNSQEPELFDCS---DELLKLLAKYAPLHE---------LMLELMERLEESSSINVFGAYLRALQVVLQRQGRDKPQAV-----EWSLNSIFTHLKDLPLPEYLSEGYD--------------------------------------QARLIEQNEQVEDLLAHYITVGLFREPLRDEILQQDVRTPSQIFRDCGVNRRNIF--------CFFIQLLGRPLALLEMNHAKEDLTRSYVQQVTESLTQDANQFLGDPFYLLNLVEQRARWLRKLDASRGVYEMSCQNVFLIEEKLPLHAVAMYYHSLFVGNQLPTNRQQEPPLQYCGLRLVEHHLSTLQHSVPTSDVHKRFCEALCKIVGYSPQVALRQLGIHVLRQ--FVLAFDDHGKYLILKNLMGTQHGGLMGYLGGMYKDLV--------------------DKALGQSGPMPEVYSGKLFREMLL-------LCVCVLPHDVKSDLLLHSDRLCHALN-ILRYFAARDKNDVTGFWQALPEIEKELLDPLGTALN----FSMAHYKAYKERVEKGQSASDDELMQRQLNMLAVNISNSGMAGGD-SKLPDIGRQEKLDVLASSITSLET-----QSLYLRAREIIEQSARLRRPRPLTFLIARSYGKDEKKANLEDFRAREEQRERERDAADQAAEKASQKEAGGGGGLGAKGSESTGPEDDAKQAKVD. 754
50 -10.800[S] KOG4346 Uncharacterized conserved protein  ali follow..  7  36.SLHFVLQCDDNREYFDLEPYSWLLSQAINLIYDVSTLESLLRVLKDYAVAPRGRKVVHTILKELDPAACLKTAQSALSAGLYVLIGAATLETPHWKHCLLQKL-TLASYLNAVAPAQLQVLLNQLLGIWSKRI-------------LQKLGSQEHLAISKLLVLAAKC-----LCGNLVMDLNIQRQLHDGLSNHLQSPDALQRHVGMWHIFEEFDELGQFESPSKTKLDEKPCEDQLKQLELHLSDFMSTTEQKEPHKPNIEIQANPAPENQNVNMQLDSDDDEPLDEDDDELKPYDSNDTTTTIDQRPKFVIDLLHLLREKVEN------QVFEGALGTAEQLIRGQLAKHDTQLALDLLQLFLVMEMQFYYEERTQFKCCVAIC--VAHPGPCAEYLCRQFHTDNSFYSASVR----LILQVLAATAKELSGDENMQNEMEIVDVIPPAAKHPRKFEFQQEEESPAARLAAAQRIIRDRLRAKTKRYFS------------PKAGDQMEKANPFHPVAGTFFFSLVRGIDTQLLVNLLNTMSVLVMCSPAMTREIFDLCAFVRFNAEARVRAATLQLIGIALVTTPAHVLAQHFAESLNELQRWLNDETSEECRELAQSILDTC....................................................................................................................................................................................................................................................... 706
51 -10.700[T] KOG2137 Protein kinase  ali follow..  10  349LRALRFLDHLLERDNMQKEFLKALSDMWKDFDSRVLRYKVLPPLCAELRNLVLQPIILPMVLTIAQSQDRTD----FELITLPALVPVLSTASGDTLLLLVKHADLITNKTDS--EHLVSHVLPLLLRAYNDNDVRIQEEVLKRSTSVAKDGQVVRQAILPRVHGLALKTTVAAVRVNALLCLAAIEILETIQRCTAVDRSAPTLMCTLAVANAILKQYGEFTAEHVLTLMMPLLTAQQLNVQQ----------FAKYMLFVKDILRKIEEKRGVTVNDS................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 626
52 -10.300[S] KOG2611 Neurochondrin/leucine-rich protein (Neurochondrin)  ali follow..  8  7.PVRKCASLLKGTKSDTEKFLFMVTKLVKGKDCNAAGKKLLFEAIG-----------FPFLKKLLVSLPNDCPPLVYKSVALSILTCFCQEEELATHKDIIDAIPTLLEIVEQADDEDYESCLKSIASHEPGQQALLATGAIPKMSQIYSAQSFQTDEALHLIVLLVKQFGVVSWPEDP----TAFHALIQRIALDMETDDTERKYELCRILADILITCRREIVINSLE------QIWPESLFKGCGDILKAKIGPKQRDPALHLIATT--EQKTFFLQLLQLGAIEVRMQMDEKKLETTFKQAELLTCCFSILEHCIEYMATDQLDLEPKEKQTTNQVLAVLTRVSQDKIRESSNPKDKKFVFAIVKVLSAWLAQETTAMRPAIYKLLPFMLKVANESFQELKTWRAGTREGEPPIDVLRIMLPALCHFAVEEEARRVLFTEVLLESLEFYFSIAHWKRPPIPRAERLKRMNEPDPVPTPEQQAEMKVARSAIVALCNILMNFTVLEPKKAEDGPTFANLLKFVLPELKDTPDNLVIHGNLAVLGLLLLKQQS----------KKVKQNDFSICRYIQATIRFLWDAYNIDESNDPTALVVSIAYKGY--SDLSELWFLGMQTMCGVLLSEFALESGWAEGIVKTLKKVKIGTPANVKSAYEDFLSQLVDVNGDVQAVLKK................................................................................................................................................................................................. 701
53 -9.470[O] COG5110 26S proteasome regulatory complex component  ali follow..  10  36............................................................................................................EQLSEEDAKLKTDL-ELLVERLKEDDSSLYEASLNALKESIKNSTSSMTAVPKPL-----------------KFLRPTYPDLCSIYDKWTDPNL--KSSLADVLSILAMTYSENGKHDSLRYRLLSDVSDFEGWGHEYIRHLALEIGEVYNDQVEKDAEDETSSDGSKSDGSAATSGFEFSKEDTLR----------------LCLDIVPYFLKHNGEEDAVDLLLEI--------ESIDKLPQFVDENTFQRVCQYMVACVPLLPPPE---DVAFLKTAYSIYLSQNELTDAIALAVRL---------GEEDMIRSVFDATSDPVMHKQEGVQDIIGNGKLSEHFLYLAKELNLTGPKVPEDIYKSHLDNSKSVFSSAGLDSAQQNLASSFVNGFLKTKGDGMTSAVASIGSI-QQLDKYLYVDEPEVKAGALLGIGISASVHDGEVEPALLLLQDYVTNPDTKISSAAILGL-------GIAFAGSKNDEVLGLLLPIAASTDPIETAAMASLALAHVFVGT--CNGDITTSIMDNFLERTAIEKTDWVRFLALALGILYMGQGEQVDDVLETISAIEHPMTSAIEVLVGSCAYTGTGDLIQDLLHRL............................................................................................................................................................. 624
54 -9.450[YU] KOG4541 Nuclear transport receptor exportin 4 (importin beta superfamily)  ali follow..  9  77..FFKLHSKIRHDETLCTKSMNCLIQ----------LASLTGDCMPVADQEASTKYVRMYISSLLELFAQGPSNWETNHLIINRLFLYRPLTSARFFGFLRDYTIHLTNQAMQKAIGEAEHEDHTSLALIYDAIVVLLRGRWRTCFSSEEEADAVDNELVKWPTLMI-------VNAFVSNLLAPPKGTRPVAKDEDDGDEDSEDRTLFMDLFNPLGAMICYSVGEFMENMATNLHTSLAEFTAMATTGSTGD-LPMWQEDQHWLMLILANSIVGEEIDGACHVSGDVFDYTQKLFHTGRKFDETKKAQYLQMCIEQPTQDRAQYALEVDPFIIVMGELFAWASIEHDVFANASREMISPELCRSTFLCLRRF--KWNDYQGVSSENLPVMPQSKEFSAILVRFVIKKVLAVLGSEEKLCQDAIDCLLSLVESHASDIASSPELFEYLNSLDIARLPNRANLMKALVLIGAAANDQELQEN----------KLILVPLSERFVSACDQPTRTDIDSQIVDYLQCFVAKASQSHSAPLFKFLYAIIDKCVGLNELVVSNILQLILDVTTKDNEDESNALYASLLQIVDTYKTDQFQRFS-------TFTADDEEKATDLALFIDILSNVLSKDFLT-AKVVIHSLEMLLTIMNDRVLQMPEVALKFFRLILYLVEFSPESLAEMSDQLMSSLCQCIR----GMTGQFGMEITSTSLESLTEVVLHFGSPANKGRCTQNLAFLFKEMLPTVFETCLSNTENSIYAESCSALYAL-FSKKSNQQARQVLEAAFTELMEVNPEPGNRRGR--VQFRSRMEQFLNK...................................................... 921
55 -9.190[Z] KOG2842 Interferon-related protein PC4 like  ali follow..  10  47............................ANERFEEKFEKALEQA--TEKSAQTRVQALQAICELLMHRYMPDFVEDRKMTLMDFVEKSIRRGKGQEQVWGARLAPLLVLQMGG-DEGISKAMNQFLLNTVQDVGFDARAKCCTAVG-LGCEDVGELVHLMQSFEAIFAGAEAGTFHAEALNAWGL-FPSIKKFLGLLQSTHLDVRMAAGETIAELSEAVKQLATDSHKYRAKRDRKAQRATFRDVLRYL.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 321
56 -9.060[O] COG5021 Ubiquitin-protein ligase  ali follow..  8  18.GYKPLVDYLID--CDTPTFLERIEAIQE--PILDRMDGLLLKVAEKYK-EAHDVDYCLKMLKFTRRLLLNTENRFVYSSG-DVLMYLLNCPNFTIKLAVMRILAILGERFVIAREKIVAHNIFGLVDLYFDQQKNNINETQTSIKKVTMTTQELCEHSLQQIFDKGMALLPAESWFDFSIKASVAKAFSDDSGENIDLRNIETKLNAIAFVNTIFSPPQVSSFNSLTDLISLSETKIPKELRTDALFTLEC--ISLKHVWCSDIIRNLGGNISHGLLFQIL--------------------------------RYIAKTLREATDEIDEEYNVRFFYLISNLADVKPLHESLFAA-----LIPTLLEIVSIRNCPYKRTLASATHLLETFIDNSETTTEFIEN-------------DGFTMLITSVANEIDFTLAHPETWQPPKYSVVYYSISFRELA---------------------------------YIRSLLKLVLKLLST-----DSGDRIRNLIDSPILVSLK-----------KILENKLVFGLTLITYTLDVVQKVINSEPTIYPVLVEAGLIPYVI---------------DNFPKLIG--PSAELLSLLPDVVSAICLNKQVKEKGLINNLFDFLLDADILTGGDRSTEYGTDIDELARHYPDLKANIVEALCNVIRKMPSTFRNEREFLFTSPKDQ--KYFFHRKNEEILTDKEEHEPAYWELLDKGTMLDTFTSVLFGMSLGNQHLEARDFLAIIFMENPPYEFTSVAISNVTEVLQYL------DEKYEDYAFMDVMKVLNDQLENLNDFLNSPNDRS.......................................... 825
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.