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Query: [R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSSTIFYRFKSQRNTSRILFDGTGLTVFDLKREIIQENKLGDGTDFQLKIYNPDTEEEYDDDAFVIPRSTSVIVKRSPAIKSFSVHSRLKGNVGAAALGNATRYVTGRPRVLQKRQHTATTTANVSGTTEEERIASMFATQENQWEQTQEEMSAATPVFFKSQTNKNSAQENEGPPPPGYMCYRCGGRDHWIKNCPTNSDPNFEGKRIRRTTGIPKKFLKSIEIDPETMTPEEMAQRKIMITDEGKFVVQVEDKQSWEDYQRKRENRQIDGDETIWRKGHFKDLPDDLKCPLTGGLLRQPVKTSKCCNIDFSKEALENALVESDFVCPNCETRDILLDSLVPDQDKEKEVETFLKKQEELHGSSKDGNQPETKKMKLMDPTGTAGLNNNTSLPTSVNNGGTPVPPVPLPFGIPPFPMFPMPFMPPTATITNPHQADASPKKLast
1 -166.000[R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger  ali  100  1MSSTIFYRFKSQRNTSRILFDGTGLTVFDLKREIIQENKLGDGTDFQLKIYNPDTEEEYDDDAFVIPRSTSVIVKRSPAIKSFSVHSRLKGNVGAAALGNATRYVTGRPRVLQKRQHTATTTANVSGTTEEERIASMFATQENQWEQTQEEMSAATPVFFKSQTNKNSAQENEGPPPPGYMCYRCGGRDHWIKNCPTNSDPNFEGKRIRRTTGIPKKFLKSIEIDPETMTPEEMAQRKIMITDEGKFVVQVEDKQSWEDYQRKRENRQIDGDETIWRKGHFKDLPDDLKCPLTGGLLRQPVKTSKCCNIDFSKEALENALVESDFVCPNCETRDILLDSLVPDQDKEKEVETFLKKQEELHGSSKDGNQPETKKMKLMDPTGTAGLNNNTSLPTSVNNGGTPVPPVPLPFGIPPFPMFPMPFMPPTATITNPHQADASPKK 441
2 -58.300[O] KOG0314 Predicted E3 ubiquitin ligase  ali follow..  15  1.................................................MTTFCRPRVEDKVENVQADMNNVITADASPVEDEFDEFGNDLY---------------SIPDAPAVHSNNLCHDSAPADDEETKLKALIDTPALDWHQQGADSFGPGRGYGRGMAGRRGFGMERTTPPPGYVCHRCNVSGHFIQHCSTNGNPNFDVKRVKPPTGIPKSMLMATPN-------------GSYSLPSGAVAVLKPNEDAFEKEMEGLT----------STTRSVGEFPPELKCPLCKEVMRDAALASKCCLKSYCDKCIRDHIIAKS--MCVCGATHVLADDLLPNKTLRDTINRILESGNSSAENAGSMCQVQDMESVRCPPPKALSPTTSAASGGEKKPAPSNNNETSTLKPSIEIAEITSAWASAEIVKVEKPVDASANIQ 355
3 -32.900[T] COG5432 RING-finger-containing E3 ubiquitin ligase  ali follow..  11  14...................................................................................................................................................................................................................................................................................TSIPSLYQLDTLLRCHICKDFLKVPVLTP--CGHTFCSLCIRTHL-NNQPNCPLCLFE-FRESLLRSEFLVSEIIQSYTSLRSSLLDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVNAADDDLQIVATSERKLAKRSMTDILPLSSKPSKRNFAMFRSE 175
4 -32.900[L] KOG0287 Postreplication repair protein RAD18  ali follow..  11  14...................................................................................................................................................................................................................................................................................TSIPSLYQLDTLLRCHICKDFLKVPVLTP--CGHTFCSLCIRTHL-NNQPNCPLCLFE-FRESLLRSEFLVSEIIQSYTSLRSSLLDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVNAADDDLQIVATSERKLAKRSMTDILPLSSKPSKRNFAMFRSE 175
5 -30.900[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  11  2...........................................................................................................................................................................................................................................................................NASTSSPSQQLQQAINSTIDKECAVCYSEMILPTTI-PSCGHKFCFICLKGVSVSNNGDCPICRGP-IDSQIFKKPLQAVDLKMDIPGTPSAAAPDP............................................................................. 96
6 -29.900[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  3..............................................QKNLNINQASGSKINTELAVPRPRQGLKRKKGFKRDDDSGGSSESSNEDMRDNIPIVSGRKKTVRLNRLQRESEQFENSALKDINVEYQSNLSATGESVNTTTVSAINEDTREVILGRPSPKLANQSTLPTELF-----DYSRFLPKRKDFEKKSQVGPVLSSNASTVRMNTIIDYQPDVCKDYKLT-GDTCKFLHMREDYKAGWQLDREWDSVQEKYK---KGAKLEEGMVKNEKKEDIPFVCLICKKDYRSPIATT--CGHHFCEQCAITRY-RKTPTCIQCGAD--TKGLFSVDKNFDRLLKN-RKSKNDEAVKQKVGGFESNNSATTEVSERKDREASFQGFADTLAKPNTSAQQKMPSLGDNSNT......................... 374
7 -29.800[S] KOG2660 Locus-specific chromosome binding proteins  ali follow..  11  2...................................................................................................................................................................................................................................................................................MIKVKKETMRACLSCSICDNILRDA--------TTISEKCIYEKITEDEIECPVCNID--PLEKLRPDHNLQDLRAKIFALKRRKVKAPGIVSLPGKRKERSISSLVVSTPMVSAQAGTTRRRTKAPTRKELRNGSLAERTVKKEESSGDELLESTSSPDTLNKFT 162
8 -28.100[O] KOG1813 Predicted E3 ubiquitin ligase  ali follow..  12  241.............................................................................................................................................................................................................................................................EEAEKVRKRNKAMGVEDEDDEADKDSDEDENALPFACFICREPFVDPVVTK--CKHYFCEHCALKHH-TKNKKCFVCNQP--TMGIFNAAHEIKKRMAEERSKAEQGLRRLWPVGEVVPKSK.................................................................. 357
9 -24.300[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  19  835.....................................................................................................................................................................................................................................................................................QEEVKNCKNILKCGVCFDRPKEVVIVK--CYHLFCQQCIQRSLEIRHRKCPGCGTA-FGQNDVRL................................................................................................... 896
10 -23.500[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  14  80.............................................................................................................................................................................................................................................................ERSRERLVENGENKTYLIAKALNMEKTSSVPGGFFDCNICLEKAEDPILTC--CGHLFCWGCFYQLP-LNIKECPVCDGE-VTDAEVIP----------------YGNGDDCDGTKPKLEDCGISLPPRPNAKRVESVRQKIINR........................................... 208
11 -23.100[O] KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein  ali follow..  14  259......................................................................................................................................................................................................................................................................IPKESQLTHINLSDKNQLPFIPEASRKCILCLMNMSDPSCAP--CGHLFCWSCLMSWC-KERPECPLCRQH-CQPQEILV................................................................................................... 334
12 -22.700[O] KOG0826 Predicted E3 ubiquitin ligase involved in peroxisome organization  ali follow..  12  1MAEAANVRQNLQNVPSIFEI----SASETLDNLIYPALSKIFDYFGLRLDFKLWGSLRIQEELSPL---LTWLLQYLYLRKRASSFGESFYG------------------------LQRTVTTTGDLLNRRQQFASATLLTFMPYRKLRTRITRHEDTSPWEQRLLSAFHAFHAAKAAHTFFYLVKYASNH----------------IFRLLGL----LRYPSEPPKEDQWTYVVLKMLEVLAFFLQFVQWWYSNDQRRKVGGTLINPEAMPRKQLPKEVQQSLPQRGECPVCLLSIQTPTACSV-SGYVFCWKCIVSHM-KEHGTCPVTHYP-ISLDDLVR................................................................................................... 293
13 -21.900[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  10  16ILGLCAREYVHYKRTAKVLKAAPQYNIGDLKSVVERQRD----KKIPYAVIRGTVTPSLVPSVSGVLQIVKLHEHRVTRGFAGFWTEQHKLLHESANEMPFELRNQSHGVEIVDALSAAVLDVDVVYDNYEPSNLSLFDHVFGFFSGVRQRGLQTTEEVLREGSFLT-------------------AIGELELDGDTLRMQPSNEGPLFLTTATKSTLIKRFEDAKTTTILKLVVCSTISAILVAFIAKKLYRKRKQEREEAKIRERLDTERRERRARSRPHTLSQDQLCVVCSTNPKEIILLP--CGHCLCEDCAQKI----SVTCPVCRGS------------IVSKAAAFIA...................................................................................... 338
14 -21.700[O] COG5574 RING-finger-containing E3 ubiquitin ligase  ali follow..  6GEAAIQYKLKKCIKRFVFELSSLGLSAETISKLM-EGHIVVPKIIINVNFDKLKTDKFAASMFKQLNASNMITTVRSNYASNVPSTPSDSTQQPPTNTLPSVSASSQSVETCETVDEDIDTQTMSSDMSEVQSMEISLNCDHEGLQREQRKILFNAIDILSHEISLIASPNSKKKYKSLYCWRKIFE---YMDS-SCKEADQSHERTPELAERHLKWFDDQVRLAKCLPSSSKHRDRILYMNKLAVTKIMKKFDKRTSLTAQPLFFQVIESDPLLLVDNASKAI-RDFECAICSNVAYKPVRLG--CSHVFCLHCLIILQKQKVDFCPLCRAKEVMADSRNIDHALMNFMKTYFPREIKEKFEENENDTFTPS.................................................................... 442
15 -21.600[DKL] COG5220 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3  ali follow..  3.......................................................................................................................................................................................................................................................................................DEGARKVDEKCPLCQA-MKLLINPE--CYHKMCESCVDRIFTTGPAQTPGCNKI-LRKAKFREQTFEDAQIEREVDVRKRISRIFNKGQQEFDSLQAYNDYLEEVEILTFNLIYKIDVEETEEKVKQYEKQNRDSIAANSARAAAEARILAQNEILLKRQKQ 169
16 -20.200[O] KOG3970 Predicted E3 ubiquitin ligase  ali follow..  50..............................................................................................................................................................................................................................................................................................DPNCSLCKTTLAEGDTIRLNCLHLLHWKCFDEWAANAGYRCPCCSQ------EVFPPINEVSPLIEKLREQLKQSNWARAALGLPTLPELNRPVPSPAPPQLKNAPVMHKEVPVHNNRSSTPATHLEMEDTASYSVSNNDVTFARKKNYGAESSS 205
17 -20.200[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  17  241........................................................................................................................................................................................................................................................................DLDVASPPKRVNRDIDESQKEELYKCPICMDSVSKREPVSTKCGHVFCRECIETAI-RATHKCPICNKK-LTARQFFR................................................................................................... 316
18 -20.000[O] COG5540 RING-finger-containing ubiquitin ligase  ali follow..  14  290..................................................................................................................................................................................................................................................................SEEEEIENSTQNGELVPLMDESTRRATFGVECVICLESFTDKVVALP-CKHEFHRPCIAKWIVDYRHACPTCNTEVPPPKPF..................................................................................................... 372
19 -19.900[L] COG5627 DNA repair protein MMS21  ali follow..  28  193..............................................................................................................................................................................................................................................................................................DNRCPLTLQPIVHPIL-STACNHFYEKDAILSLL-NPTCVCPVCEAR-LQRSLLKEDEILERRLRRAQEISNLKEA............................................................................... 267
20 -19.800[O] KOG3800 Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor  ali follow..  2................................................................................................................................................................................................................................................................................................ECKKCKSNEKQLVMMINECGHPLCKNCVDNIFALNSGNCHVCNRV-LRKNNFREQIYEDPLIDKETFLRRKLRKIYNLKQDDFENLREFGDYQERKFFEPLKFPVKIKISNFRRFKNFKNFFYEFSIRYSNSPSFSWSNPEFSAQNSKIAPSN 156
21 -19.300[O] KOG4265 Predicted E3 ubiquitin ligase  ali follow..  257............................................................................................................................................................................................................................................................................ENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILP--CRHCLCTSCADT-LRYQANNCPICRLF------------PGPPADPGGAEEARSPVPRVLQPRPGPEPGA................................................................. 350
22 -18.900[O] KOG0006 E3 ubiquitin-protein ligase (Parkin protein)  ali follow..  11  1..MIVFVRFNSSHGF-PVEVDSDT-SIFQLKEVVAKRQGV-PADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHQPGKLRVQCSTCRQATLTLTQEFFFKCGAHPTSDKETPVALHLIATNSRNITCITCTDVRHICLDC-----------HLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQM----------------GGVLCP-CGAGLL-EGGNGLGCGFAFCREC-KETIKKTTKPCPRCHVP............................................................................................................ 396
23 -18.500[R] KOG2979 Protein involved in DNA repair  ali follow..  17  228............................................................................................................................................................................................................................................................................PGDDDEDIVMTSTQCPLLNMTCPLSGTELADPVR-SMDCRHVYEKSVILHYIVNNPNNCPVCRGK-LQNSKVICDAMLKFEIEEMRSLNKQSNRAEVIEDFTEDVDED................................................................. 339
24 -18.300[O] KOG4159 Predicted E3 ubiquitin ligase  ali follow..  21  2......................................................................................................................................................................................................................................................................................................RLFFEPVTTP--CGHSFCKNCLERCL-DHAPYCPLCKES-LADRRYCVTQLLEELIVKYLPDELSERKKIYDEETAELSHLTK................................................................ 84
25 -18.200[R] KOG3002 Zn finger protein  ali follow..  14  2..........................................................................................................................................................................................................................................APGGSALKEALESNSTGVDYEVKMAKVEANSKPTKSGSGSIGKFHSSNGVYELLECPVCTNLMYPPIHQ---CGHTLCSSCKLRV----QNTCPTCRYELGNIR----CLALEKVAESLE....................................................................................... 112
26 -17.500[O] KOG0800 FOG: Predicted E3 ubiquitin ligase  ali follow..  96.............................................................................................................................................................................................................................................................................................MDSQCSVCLGDYQDKLQQIPVCKHTFHMDCI-DLWLTSHTTCPLCRL------ALIPSRSRQSQDDPVPSLVSPDEEVSSQPESEPVNHRVVSTQPESEPVNHSGVSSQPESQPVVNHRGVSSQPESQPVNHINDGHEQQCDQDVEGFKEMEEDER 246
27 -16.300[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali follow..  11  321.....................................................................................................................................................................................................................................................................WRNNKQLDDTLVTVTVEQLQNSANDDNICIICMDELIKKPKRLP-CGHILHLSCLKNWM-ERSQTCPICRLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDE 510
28 -15.700[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  15  624....................................................................................................................................................................................................................................................................KQELLDRVSRLWKTMRECPAVEKLATDELCKICMDAPIECVFLE--CGH--CTSCGKVL-----NECPICRQY------------IVRVVRFFRA...................................................................................... 700
29 -15.400[O] KOG4628 Predicted E3 ubiquitin ligase  ali follow..  235.................................................................................................................................................................................................................................................................................................CVICLEDFIDKLRVLP-CSHPYHTHCIDPWLTENRRVCPICKRKVFTKGEARASRSRQPSLDNVTDTDDDTTPLLQQQQSNGRQVGQVSSASSAGGAAGSSSSVAAAAVAGTTRHGTFRRGHAGRNPFEESQSSDDENALLASTVRPATSSG 387
30 -15.400[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  35...........................................................................................................................................................................................................................EEEEDEEEAYVDYGEVQEEDEEEEEEEDSERQTREYIDVLDSPVRVSQNESEGIENQNRRMSNGNKVTLRDCLVLSVWKFG-VANTKSGILDSIVFPVDTCMDSTSGFSSDEVE-GSLRDVRKDDEAHKRILFLEAKLRSIEQKTASWSNKEVQWKITEAELRLEVTKLKKKIANMESTTKGSQSQSNVASQEKYIPAHNIYQEHHGQSPS........... 257
31 -15.300[O] KOG0802 E3 ubiquitin ligase  ali follow..  330..................................................................................................................................................................................................................................................................KGYIKLRIALGALHAALPDATSEELRAYDDECAICREPMAKAKRLH--CNHLFHLGCLRSWLLNEVYSCPTCRK------PLFVGRTENEVNPRTVEVSSDEQLARQLERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGLGRVQMMMRHLASVGE 507
32 -15.000[O] KOG0801 Predicted E3 ubiquitin ligase  ali follow..  16  180.............................................................................................................................................................................................................................................................................................DAGECVICLEELLDTIARLP-CLCIYHKSCIDSWF-EVNRSCPEHPAD............................................................................................................ 227
33 -15.000[DR] KOG4739 Uncharacterized protein involved in synaptonemal complex formation  ali follow..  4...............................................................................................................................................................................................................................................................................................IQCNHCGIKPNQTKLYLTACGHVFCQNCTKA---AFNSQCYLCKKP-LKVDEINKNLRASDLVNELKQVVAFQAKQREIYVKCKNAEAKKDTERFAEARSKHVEKTQEIEKRKKAFLEDNVKLKNAKEEKNQLMARLKELREQPSQNLSVNKRR 166
34 -14.700[R] KOG2789 Putative Zn-finger protein  ali follow..  147.............................................................................................................................................................................................................................................................................................NAMECPICFLYYPSNFNYTRCCAQPICSECFVEDLISEPAKCPYCMT---------ERFGVIYKPNPKLTPFSFNNNPDTLPSNIAPMGTLSKSSLPLHHIPWPPNQHIKFAHDDKNVVSTDFIHPDWQYKLERARRRALRRAANATLLNSHLLE. 313
35 -14.400[O] COG5113 Ubiquitin fusion degradation protein 2  ali follow..  614LLYALLDFYSSSQFYDKFNS-----SISIILEELYYKIPSYKNQ---LIWQSQNNADFFVRFDARMLNDLTFLLDEG-----SNLAEVHNIQNELDNRARGAPPTREEEDKELQTRLASASRQAKSSCGLADKSMKLFEIYSKDIPAA-----------------------------PEIVYRLASMLNYNLESLVGPKCGELKVKDPQSYSFNPKDLLKALTTVYINLSEQSEFISAVAKDERSGRKTGLASPEFIEKLLNFANKAEEQRKADEEEDLEYGDVPDEFLDPLMYTIMKDPVIL-PASKMNIDRSTIKAHLL-SDSTDPFNRMP-LKLEDVTPNEELRQKILCFKKQKKEEAKHKASE.......................................................................... 961
36 -14.000[O] KOG1100 Predicted E3 ubiquitin ligase  ali follow..  14  259.....................................................................................................................................................................................................................................................................EGDSEEERWKLAGEAQDTKKMCRVGMSMCRSCGK--EASVLLLPCC---LCSVC------SSLNTCPICKSP------------KTASLHVNLSS..................................................................................... 335
37 -13.800[O] KOG4692 Predicted E3 ubiquitin ligase  ali follow..  14  427.....................................................................................................................................................................................................................................................KFALNDFPSHVSSEEIDNVRRLIDSLRVKQTLLSDITLPSEDSLCPICCAKPITAVFTP--CKHQSCSDCIMQHMMNSK-VCFYC----------------KTTIQTIETLDGTVIFSNDDVVQTPMIERA................................................................. 538
38 -13.600[O] KOG0827 Predicted E3 ubiquitin ligase  ali follow..  3..............................................................................................................................................................................................................................................................................................NLNCVICAELFGDEVFATV-CGHMFHHNCLNQWL-DRSKTCPQCRNK-------CTTRNIFRVYFNLANLDVSHIDVGSLQEQLDNAMLSMKMVEKERNKDEQQIRDLKETQKKCLKTIAGLEQKVQKKDFLISSYVEQIGVLKSDAHVVDGLRK 150
39 -13.600[O] KOG2879 Predicted E3 ubiquitin ligase  ali follow..  289.....................................................................................................................................................................................................................................................................LLNSSAVKNILSPFAKDKSSSTKEDTVTCPICQVDPAIPFIALPCTCRRYCYYCIRTRCASASFRCLRCNEPVVAIQREGVSSG................................................................................................ 388
40 -13.500[DO] KOG1493 Anaphase-promoting complex (APC), subunit 11  ali follow..  11  68.............................................................................................................................................................................................................................................................................................GEDTCGICRMEFEDCPLVLGICRHAFHRHCIDKWIAQPRAQCPLCRQDWTIVE....................................................................................................... 135
41 -13.200[T] KOG0297 TNF receptor-associated factor  ali follow..  22  26.........................................................................................................................................................................................................................................................................................TKLEAKYLCSACRNVLRRPFQAQ--CGHRYCSFCLASILSSGPQNCAACVHSILESSSAFPDNAARREVESL........................................................................................ 103
42 -13.200[O] KOG0828 Predicted E3 ubiquitin ligase  ali follow..  16  681...............................................................................................................................................................................................................................................................................SNEYISEHGGGTAEHTVDCAICMSDVQHSYMVTP-CNHVFHTSCLEN-WMNYKLQCPVCRSP------LPP................................................................................................... 757
43 -13.100[S] KOG3899 Uncharacterized conserved protein  ali follow..  12  158VASEIGIEFRQ--------PEIYKKKLNSISSVIATQNHFAHQSNTSLSVAKAETYNISHQDQNDTLQMISIIVRPMRQGVSDFHIRINALEFRNLENRVRRPIAIPSNIQLHRNVIDRFVDVFKAQVAQNPIFPDDATTEK---------------------------------------CFACMLNEPNTKQCADFDR-------------------------------------------------------------------------------NGAPLANGACCSNCY------------CRPMWCVECLREVWLEQKCTCPMCRAKFCVLD-----------VSYITTTVDATNSTQSQGTEEDTNDTT................................................................. 409
44 -12.900[OD] COG5194 Component of SCF ubiquitin ligase and anaphase-promoting complex  ali follow..  15  54................................................................................................................................................................................................................................................................................................NCAICRNHIMECVAAWGVCNHAFHLHCINKWI-KTRDACPLDNQP............................................................................................................ 113
45 -12.800[OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger  ali follow..  62....................................................................................................................................................................................KCNNCSQRGHLKKDCPHI----------------------------------------------------------------------------ATDDHYSRHCPKAIQCSKCDE-------YRSQCPHK-CTLC------HSKERCPSCGGKGHFGDDCLSVELKQEYYRHMNRNSDENEDYQFSESIYDEDPLPRPSHKRHSQNDHSHSGRNKRRASNFHPPPYQKSNVIQPTIRGETLSLNNNISKNSRYQNTKVNVS 298
46 -12.500[S] KOG4445 Uncharacterized conserved protein, contains RWD domain  ali follow..  10  103.............................................................................................................................................................................................................................................................................................PSGQCVVCLYGFADEFTRTE-CFHYLHSYCLARHLNALRRLCPVCREHETDSLKCAMPPSELLNAPEFKVTEELRQMQQRMSELYLQQKSRGAIIDVNAEGSAVISIETEEDIRRRRRREEAEAAKKLEGPSKEEVIKPTTSSTFAPVVQETHRIM 284
47 -12.300[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  10  161.................................................................................................................................................................................................................................................................TKSGRKIQRPVAYNPNATALKRKSRKVDMVTLCSVCQR--SNRIVF--CCNSPYHQLCHHPPI-DAEWFCMKCQYRRAKQPSSLPTPHLADLILFCEKSYPSLPIYNPRTRELLGEIRHQLLVSSERQQISLQERLHAKQDEAPSDEPAPVPYTASYVANSGTLYDYPTLIRLAIRNTLSPSKD 375
48 -12.200[O] KOG4185 Predicted E3 ubiquitin ligase  ali follow..  10  2.............................................................................................................................................................................................................................................................................................SFIDCEICDEEFSTPRILR--CGHTTCHGCAEKLLRNSTILCPFCREATNVVKDLQKNFALLQAVEHTKTKTEEKDSIDAPPKCASHQYNLAEPTCRSSDKLMCRTCEEFGAHAGHKKGLLQSEAAKLRQFLSGKLSRSEELASQIETNIEKIGRA 168
49 -12.200[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  1MAAVV--KLLGEQYYKDA-----------MEQCHNYNARLCAERSVRLPFLDSQTGYIWMEKRHRGPGLASGQLYSYPARRWRKKRRSSLEALLRTDPLEKRGAPDPRVDDDSLGEFPVTNSRARKRILEPDDFLDDLDDEDYEEDTPKRRGKGKSKGKGVGSARKKLDASILEDRDKPYACDICGKRYK------PGLSYHYAHSHLAEEEGEDKEDSQPPTPVSQRSEEQKSKKGPDGLALPNNYCDFCLGDSKINKKTGQPEELVSCSDCGRSGHPSCLQFTPVMMCNICGTSENDDQLLF-CCDRGYHMYCLTPSM-EGSWSCHLCLD............................................................................................................. 376
50 -12.100[O] KOG2177 Predicted E3 ubiquitin ligase  ali follow..  2....................................................................................................................................................................................................................................................................................NSGILQVFQRELTCPICMNYFLDPVTID--CGHSFCRPCFYLNWQDMAAQCSKCKET-TWQRNLNTDICLKNMASIA-RKASLRQFLSSEEQICGMHRETKKMFCEVDKSLLCLLYSNSQEHRNHRHCPIEWAAEERRSLWEKACENLRNLNMETTRTRCWKSFG 164
51 -11.800[S] KOG4367 Predicted Zn-finger protein  ali follow..  22  2.........................................................................................................................................................................................................................................................................................EEMEEELKCPVCGSFYREPIILP--CSHNLCQACARNILVQTPITCPQCHRSLILDDGFPKNRVLEGVIDRYQQSKAAA................................................................................. 165
52 -11.800[O] KOG3268 Predicted E3 ubiquitin ligase  ali follow..  12  294....................................................................................................................................................................................................................................................................................ARAILEKSDFTMDCGICYAYQLDGTIPDQVCDNSQCGQCLYEWLRGLLTECPYCSKP............................................................................................................ 365
53 -11.600[O] KOG2930 SCF ubiquitin ligase, Rbx1 component  ali follow..  15  54...............................................................................................................................................................................................................................................................................................IECQANQASATECTVAWGVCNHAFHFHCI-SRWLKTRQVCPLDNRE............................................................................................................ 100
54 -11.300[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  605......FTIDNVMKFSVSALEHRVYEVRETAVRIILDMYRQHQASILEYLPPDDSNTRRNILYKTIFEGFAKIDGRATDAEMRARRKAATEEAEKQKKEEIKALQGQLAALKEIQAEVQEKESDAVKPKNQDIQGGKAAPAEALGIPDEHYLDN--------------------------LCIFCGERSHYWKHCLM------------------------------------------------------------------------------------------TRCDHCKQVVEISSLLTECCYR--CSECNPAKPEKLANRCPLCHE------NFSPGEE-----AHLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSKIPTPKGGLSKSSSRTYAKR.......................... 925
55 -11.200[KL] COG5242 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4  ali follow..  20.........EESPSLLTVIIEIAPKLWTTFDEEGNEKGSIIKVLEALIVFLNAHLAFNSANKVAVIAAYSQGIKYLYPESTSALKASESENKTRSDLKIINSDMYRRFRNVDETLVEEIYKLFELEKKQIEQNSQRSTLAGAMSAGLTYVNRISKESVTTSLKSRLL------------------------TCGSGSSKDEIFQYIPIMNCIFSATKMKCPIDVVKIGGSKESTFLQQTTDATNGVYLHVESTEGLIQYLAT----FIDPSLRPIIVKPNHGSVDFRTSC-YLTGRVVAVGFICSVCLCVLSI-------IPPGNKCPACDS-------QFDEHVIAKLKRKPVVPRLKAKKKVTK........................................................................... 337
56 -11.200[O] KOG1039 Predicted E3 ubiquitin ligase  ali follow..  14  206.................................................................................................................................................................................................................................................................PEQRKAHEKICMLTFEHEMEKAFAFQASQDKVCSICMEVILEKASILSNCNHTYCLSCIRQWRCAKQFSCPECR---VISEFVIPSNKKNELIEAFKQGMGKKA................................................................................ 326
57 -11.200[O] KOG3579 Predicted E3 ubiquitin ligase  ali follow..  17  397......................................................................................................................................................................................................................PMAALILVADNAGGSHASKDANQVHSTTRRNSNSPPSPSSMNQRRLGPREVGGQGAGNTGGLEPVHPASLPDSLCCTLCHERLEDTHFVQ--CSHKFCFPCSRQSIASGEVYCPSC-----LVGSNVPWAFMQGEIATILAGDVKVKKERDS........................................................................... 560
58 -11.100[K] KOG4218 Nuclear hormone receptor betaFTZ-F1  ali follow..  10  1..........................................................................................................................................................................................................................................................MSSNSDTGDLQESLKHGLTPIVSQFKMVNYSYDEDLEELCPVCGDKVSG---LLTCCKGFFCQNCQIDK--TQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPH 206
59 -11.100[O] KOG2164 Predicted E3 ubiquitin ligase  ali follow..  10  1...............................................MLNGEKSALGEMPSNSNSSSKLNAKSPNFIPSSSNIPRSSAKTKEHSADRKPHRNSEKKTQGMPRKNQQLASSERKTKNKKRLEKQSSAIADSIGESLDDPQTVYDEHLFDILSARTNKRGQIN-----------------NHLLNFQFTPRTNSNAFSAPPRRSRGYNTYGQGSGHHPMDKSRYVNANYRFVVSPIGDYQSQKLDPDSPVK--------------EDVWQVLCSSDFQLAACPFCLEEKPVAARMSR-CGHVYCFSCLLRFVETPTRSCPICWDS-IRLRDVHP................................................................................................... 283
60 -10.800[O] KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase  ali follow..  14  75.................................................................................................................................................................................RDKFCFACRQQGHIVQDCPEAKDNV----SICFRCGSKEHSLNACSKKGPL---------------------------------------------------------KFAKCFICHE-------LSGQCEQN-CKFCSSVHHLAKD--CDQVGVAGTTGADEDVYHEYAKTVAAPTKKRPVKPVKK............................................................................. 214
61 -10.600[DR] KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins  ali follow..  273MRTFMYWPSSVPVQPEQLASAG-YVGRNDDVKCFCCDGGLRCWESGD---------DPWVEHAKWFPRCEFLIRMK-------------GQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAEMASDDLSLINRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIP--CGHLVCQECAPSL-----RKCPICRGI------------IKGTVRTFLS...................................................................................... 618
62 -10.600[R] KOG1313 DHHC-type Zn-finger proteins  ali follow..  10  2....................................................................................................................................................................EDSSQGSFVATINEDYICWGCGLNLVLPSYAPVF---------CGAITNQNPVRPETKSFGLRRFRDRCFVVILAVFMLFVISTLAISTLSTFILVAFKCAGKPTNILYGTHPGVGNGALNNYTFCNYCSKP--KSPRTHHC---RTCGMCV----LDMDHHCPNC............................................................................................................... 158
63 -10.500[O] KOG4172 Predicted E3 ubiquitin ligase  ali follow..  14  2.......................................................................................................................................................................................................................................................................................GAQEVNEGDECTICMDAPVNSVLYT--CGHCMCFECGRR-LLTTKGTCPICRAP------------VQDVIKTYKS...................................................................................... 63
64 -10.500[R] KOG3362 Predicted BBOX Zn-finger protein  ali follow..  11  1.............................MK---IAQSKLFQGK-------NRLSSKLFKNSYLNCRRNEA--GRHFSDIKCAFSKLIFLFLSTILISKMFAPSRKPAATANQLRASSRISNLEGNRTLDENARRNRRNRQLDGLEQDNSHDDPHANLVWN-------------------------------KNAPKFDDEMIGGPSAKKAKKVKEDKSGIVHGEKARRRKLARPEFNKQRFKKS---FNAHVIEQSKAILDSAEPDYRRVNAYQLSSAPPSEKPARKFCAVCG---IISKYCCTRCGAKYCSPCRD---VHNDTRC.................................................................................................................. 258
65 -10.300[T] KOG3575 FOG: Hormone receptors  ali follow..  9......................................................................................................................................................................................................................................................................NMLQSDHALIMSSFPEPSPSSKRPTENCKVCGDRPNN---ASACCTVFFCQNCLISC--TYRNACRYCR--------------FQKCFAVGMHSSAIQRRDLVGPRKISGDGEVIICENNTFLDDFASFQRTQFAEHLQYFTEHQVDVAFHVDQANVVKFRRRARAHD........... 177
66 -10.300[O] KOG1814 Predicted E3 ubiquitin ligase  ali follow..  12  79................................................................................................................................................................................PEAY---------------PFNSPPTFFL----KSSWLPLKQKRVLTSSLIKLWNEIHDC--DAIEHVRSIATIAFHLPTEMVFPGGFDDLKKEILAFDKNAKLLEFQIRKFQCNVCDEFNGTDCFQLTRCGHVSCQSCLRDYYTMCQIKCIDCGKD--ELESIVGVQLTNRYKELEEKRRYENDSN.............................................................................. 262
67 -10.300[B] KOG4718 Non-SMC (structural maintenance of chromosomes) element 1 protein (NSE1)  ali follow..  19  181.................................................................................................................................................................................................................................................................................................CNICHSLLIQGQSCET-CGIRMHLPCVAKYFQSNEPRCPHCNDYWPHEIPKVFDPEKERESGVLKSNKKSLRSRQH............................................................................ 256
68 -10.100[R] COG3582 Predicted nucleic acid binding protein containing the AN1-type Zn-finger  ali follow..  17................................................................................................................................................................................................................................................................................................HCAYCRQL----FLPFHCCNEDFCSN----HRLKEDHHCRWLLEHEEVHKTEKSPSKSRDG-AYFKSLLPERASVRIQRVSETREPLRGSNTAKVSSTLNSKTLDKIFKFFQRNEKRKSNNKSKKNFGSSSNKIIQLANLKKIAKGDPKIPMQ 169
69 -10.000[R] KOG4299 PHD Zn-finger protein  ali follow..  2............................DAKPWNHTSEAFQASILEDLKIIQKAGAERNAKSSHGSINSRSASPNKATSRRNRAQNGNSNGRASVDNSDDGSKDDLDYSPSVKRKHVNGEGAEKGDHDTSNNGPSITKLRRKVRRTYDTKDGFVAWNTLDDDFRPIVPDQERSRKINPQ----KGNNNNLLKENKSLKTTAKDLSDISSSSMKKANNSSKPLFSGKLTFKANIPVPTSEVVTENNVTRNVTVYSNQKHLGNESENFNDMEGRAEDISSNELLPTPEE-YCSACHNFL--------CCPNSFHFTCIEKNLPDDAWYCNECKHH............................................................................................................ 312
70 -9.990[K] KOG2068 MOT2 transcription factor  ali follow..  14  4............................................................................................................................................................................................................................................................................................YGEKTCPLCAEEMDTDQQLKPCCGYQICVWCWHHIMDMAEKRCPACRTP-YDKEKIVGMTVDQERLASEGNMDRKKIQKSKPKSSDGRKP................................................................... 99
71 -9.890[L] COG0551 Zn-finger domain associated with topoisomerase type I  ali follow..  2................................................................................................................................................................................ETDIKCPTCGRNGVFL-GCTGYALPPKERCKTTINLIPEAELLNVLDESS----ETKALMDRKRCTKCGTAMDSYVIDAHRKIHICGNNPNCDGYLIEEGSFKIKGYDGPVVECDKCGADMH--------CTN--CEKSDAYFVLRDGASAPKSRET............................................................................................................ 197
72 -9.880[B] KOG1973 Chromatin remodeling protein, contains PHD Zn-finger  ali follow..  10  1MSSAIYLE-KHGKHSKTYIIHDLQTGLESLPTEL--ERNFKLMRKLDDRAQTAMKS---------IDSHAKDFMRKLGENGAMSEDERRERQEDIKALFGKAKEYSDDKVQLAIQTYELVDKQIRRLDNDLARFEGEIQEKASSTRAKSEEVVAKSKTVPKYLFFHKLTPSFDSICTEG-------------KDSKTTGKKKKSASSDEETGRGNNQSNANSSVNSSSNAGQGSKKKKSKVNQEKETRKGGAQKKTVEVDDSEKESCHTAATHPSDVMDMPVDPNEPTYC-LCHQVYGEMI----GCDNPDCPACV-TTKPKGKWFCPKCTQD............................................................................................................ 324
73 -9.860[K] KOG2169 Zn-finger transcription factor  ali follow..  11  408................................................................................................................................................................................................................................................................................SGGEDDIAMDRLNISLLDPLCKTRMTTPSRCQD-CTHLQCFDLLMMNEKKPTWQCPVCSSN-CPYDRLIVDDYFLDMLAKVDKNTTEVELKEDGSYDVIKEEAFCISDDDDDDVVPATVNGTASCSSTNGNGLANEAAKKKPADDDIITLSDDDDEELNRGIMNSLNDS 577
74 -9.860[K] KOG2845 Activating signal cointegrator 1  ali follow..  11  1MAVAGAVSGEPLVHW----------CTQQLRK-TFGLDVSEEIIQYVLSIESAEEIREYVTD--LLQGNEGKKGQFIEITKWQKNDQELISDPLQQCFKKDEILDGQKSGDHLKRGRKKGRNRQEVPAFTEPDTTAEVKTPFDLAKAQENSNSVKKKTKFVNLYTRERQDRLAVALPGRHPCD-CLGQKH-INNC---------------------------------------------------------------------------------------------------------------CGRIVCEQ-------EGSGPCLFCGTL------VCTHEEQDILQRDSNKSQKLLKKLMSGVENSGKVDISTKDLLPHQELRIKSGLEKAIKHKDKLLEFDRTSIRRTQVIDDESDYFASDSNQWLSKLERETLQK 308
75 -9.860[S] KOG4638 Uncharacterized conserved protein  ali follow..  356...................................................................................................................................................................................................................................................................................SYATTEQATCVPSARRRCTPQFFAKIAFQ--SGEVFLHIAIIFVY......................................................................................................................... 405

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.