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Query: [S] COG5291 Predicted membrane protein, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPSIPQMNNTFLLGQMLRVPPITRYMTLLISAVALLVYVDAVSPYSLYYSPLFLKRLEIWRVFTSFLYFGKPTLDMFMHVVFLYRYSRMLEEGCVNTSEYFWLILVISSVLFAISNIYGISALGTSFSATITYIWTKRNPRAIVQIFGFISFPAFYLPFILPGFMLLSRRSISIDDVLGIVVGHLFHYFKDVYPRWGRDILSTPCWVKKLFNEHPSSCCKARKGITIREGRERHERNMGYSNASTTSGDSMASLTDMADTKSSTENSAVTEESQCCAESFKDSSVVSSQKSMAVSTVVGSSTEAKNNYLDFTEALCDKEVVAEQNPESQSNEEWDEKWGDSDNESECSLast
1 -118.000[S] COG5291 Predicted membrane protein  ali  100  1MPSIPQMNNTFLLGQMLRVPPITRYMTLLISAVALLVYVDAVSPYSLYYSPLFLKRLEIWRVFTSFLYFGKPTLDMFMHVVFLYRYSRMLEEGCVNTSEYFWLILVISSVLFAISNIYGISALGTSFSATITYIWTKRNPRAIVQIFGFISFPAFYLPFILPGFMLLSRRSISIDDVLGIVVGHLFHYFKDVYPRWGRDILSTPCWVKKLFNEHPSSCCKARKGITIREGRERHERNMGYSNASTTSGDSMASLTDMADTKSSTENSAVTEESQCCAESFKDSSVVSSQKSMAVSTVVGSSTEAKNNYLDFTEALCDKEVVAEQNPESQSNEEWDEKWGDSDNESECS 348
2 -82.300[S] KOG0858 Predicted membrane protein  ali follow..  22  2..........DAGVWYRSLPRFTRYWLTATVVLSMLCRFDVIPLHWLHLDRSVFSKLQLWRCMTSLFVFPISSFHFLINCFFIVQYSSKLEKDQYSPADYLYLLIVSAVLANIGGMIFNVYFLMDTLVLAITYIWCQLNKDVTVSFWFGTRFKAMYLPWVLAAFEFIFHFS--LASLVGIFVGHVYYFFKFQYSQGGTPLLETPQFLKRLVPDVSGGFGGFGLPP------ESRAPPRQATESPWGRGMTLGRN.............................................................................................. 245
3 -36.600[S] KOG4463 Uncharacterized conserved protein  ali follow..  11  1........MSSANIVPSNMG-ITKFLLLTISTSSVVAGVALKPFFHINFGLHLLSHYQYWRILLWQFIYWNST-EVFQALFIIY-QARDVERLLGSHRFASFCVYMFILGMFVTPIFSFLYSLLTFLIFAILYQYYYIVPSTVFVRLFNIKFTDKFQMVIPIGLAFSHFPSTFINAFLGWTMGMFY-----HLSLLPGTSWRLPIRFVKPALSPTHVFIRPPYSDMQNASTFNPETLFALPTGLDAERTENENQVENPVSNADANDSPTRQNARATAIASSSNTAASFRNRQQISHPPLGRTSSSSVLPTGPASQLYDMLSGRSERPELGNIREEDQTNDVQREQTAD 371
4 -33.500[S] KOG2632 Rhomboid family proteins  ali follow..  11  1MRPNIVTEAGRVGQWWNAIPFLTSSVVVVCGVIYLICLLTGYDTFY-FLPSAIISRFQVYRFYTAIIFHGSL-LHVLFNMMALVPMGSELERIMGSVRLLYLTVLLATTNAVLHLLIASLAGYFSGILFSMIVIETSLSGVTSRSVFGLFNVPAKLYPWILIVFQLLMTNVSLLGHLCGILSGFSYSYFTTIESASWMLIVTHPVSMSSSSLASLGDPSSLCVLAGILPAIFPLILHKTQHPGNAWRSLSSWLPQREASNQSSEDSRFPGRGRTLSTARDPTAPAGETDPNLHARLLEDSSSPDRLSDATVNTVADSRQAPIANAAVLPQSQGRVAASEEADDDLTVA 402
5 -31.200[S] KOG2890 Predicted membrane protein  ali follow..  12  14........VERHSDVLRNNALPFRFLVVLRIIGYIISYLHFARLL-LWLHPYQIASIELWRIATSTFCGHNV-LDVLWTVWCLHFGTNLVRLNNTNESLLKLYAITQGVTTFVIVVFAYLTYIMTPICASVMVLMKQFLPDTIVLATPLGRIKYAHLPFLAIFVSFILAFVSFLQITIGVQVSWTYFTWASLFPSRTQLFFTL---IGKVCFRTLARMGVCKRQVRHVDLHSLQSGSVGINLPALENSAKDSERRRQKALKELNDRLNKTRTAEVASYGNWDDGDDDEPTEVTVVAPPPVSNVHSSKPAMDKESMA................................ 356
6 -16.800[R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid)  ali follow..  13  75NSGLRYRRFPFLATLRERAGPVTWIVMLACVLVYIAMSLDQTVMVWLAWPFDPVLKFEVWRYFTHIFMHFSL-MHILFNLLWWWYLGGAVEKRLGSGKLIVITVISALLSGYVQQKFSGPWFGGLS-LMGYVWLRGERDPQSGIYLQRGL-IIFALLWIVAGWFDWFGMSMANGAHIAGLIVGLAMAFV............................................................................................................................................................... 267
7 -14.500[T] KOG2980 Integral membrane protease of the rhomboid family involved in different forms of regulated intramembrane proteolysis  ali follow..  11  143...................KNLVYALLGINVAVFGLWQLKCWRFLQKYMLLQKDYVTSKISIIGSAFSHQEF-WHLGMNMLALWSFGTSLATMLGASNFFSLYMIAGSLFSLWYPKLARLAIVGPSLLFGVLGCFSYLFPHAKILLFVFVPGGAWVAFLASVAWNAAGGSFDYAAHLGGSMMGVLYGWY............................................................................................................................................................... 326
8 -13.400[S] COG3767 Uncharacterized low-complexity protein  ali follow..  10  2.....................................................................................................................................................................................................................................................NKNIAAALAGALSLSLAAGAVAANKPASNATGVHKSAHGSCGASKSAEGSCGAAGSKAGEGKCGEGKCGATVKKTHKHTKASKAKAKSAEGKCGEGKCGSK.. 102
9 -13.400[K] KOG2478 Putative RNA polymerase II regulator  ali follow..  9  397...................................................................................................................................................................................................................EQEKGSSSEKEGSEDEHSGSESEREEGDRDEASDKSGSGEDESSEDEARAARDKEEIFGSDADSEDDADSDDEDRGQAQGGSDNDSDSGSNGGGQRSRSHSRSASPFPSGSEHSAQEDGSEAAASDSSEADSDSD.. 531
10 -11.800[R] KOG3263 Nucleic acid binding protein  ali follow..  7  59...................................................................................................................................................................................................................PARRRDRYERHRESVREESPRRPVEHERNWQPELKHGRERFRERDYEGRRDRKERRDGVSPFSPEGEGLERKREHEKLQAPSPKEEEERPVDQGDKMDGVKEDKDGSLEVGKSHDAMTRTKSAEEEIVEQEDEATAE 195
11 -11.000[R] KOG4095 Uncharacterized conserved protein (tumor-specific protein BCL7 in humans)  ali follow..  7  64...................................................................................................................................................................................................................SSAAREPNGFPSDASANSSLLLEFQDENSNQSSVSDVYQLKVDSSTNSSPSPQQSESLSPAHTSDFRTDDSQPPTLGQEILEEPSLPSSEVADEPPTLTKEEPVPLETQVVEEEEDSGAPPLKRFCVDQPTVPQTAS 200
12 -11.000[R] KOG2945 Predicted RNA-binding protein  ali follow..  8  8.......................................................................................................................................................IVALMFP--AIDVSTFTFVSGVKFYIMDNSGNNRYELLFM-----DDDSSGLAQPQIAAVVAAPKKPEPAKAPKAPKSKSEKENKPVVAARKANAPVAKNASPVKGGKGPAGGDVGRPKNPTANGANNQGRFNNNQRYGNKEGPPRVRTGEKFGKREFDRQSGSDRTGVKSIDKREGGGAHNWGSPKQDIEDLKTTG 198
13 -11.000[Z] KOG3756 Pinin (desmosome-associated protein)  ali follow..  10  575...................................................................................................................................................................................................................SRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRDTKGSKDKNSRSDRKRSISESSRSGKRSSRSERDRKSD 711
14 -10.900[KB] COG5137 Histone chaperone involved in gene silencing  ali follow..  12  34..........................................................................................................................LKSDLEWKLTYVGSATSQDQILDTLLVGPIPIGINKFVFEADPPNIDLLPQLSDVLGVTVILLSCAYE------DNEFVRVGYYVNNEMEGLNLQEMDDAEIKKVKVDISKVWRSILAEKPRVTRFNIQWDNPDFDDAPPVQPDADEEEEEEEADEMEEEFDEEGEGDEEEEEEDDGDGDGEGDGDGEGENDGKGSEEEEEEEIDIEEEEEESALANASAAEEKPE 255
15 -10.900[S] KOG4149 Uncharacterized conserved protein  ali follow..  12  64..................................................................................................................................................................................SLTAGYLLGK---------------------------------NTSNASSSQDNDHPVVGEHVHTETQSYNEPYMQRHRIEDAIEKKMTSETQPSTDEKGRKVSATENSAPKKTDKEKSSGETAGNILREQIATGKDDDEYARKFEEVEEESSEESAFNPDTGEINWDCP 200
16 -10.600[S] COG4530 Uncharacterized protein conserved in bacteria  ali follow..  13  42...................................................................................................................................................................................................................................................................EETSVAKVLEKEEEEDVKEVDTENTEVELVSLEEADDEASGGDDLPDLGDDDVEIEGDDDDTFLQTDDEDDDDDMSDIIGVSDEDDD.. 128
17 -10.200[R] KOG3116 Predicted C3H1-type Zn-finger protein  ali follow..  11  109...................................................................................................................................................................................FQAGHWTY-------KNERVYISRPSRTQQLKNPKLRTKPSVDDLDGSDDDDEEERPDATNGKAEVEKRSKKSKRKHRSKSDSESDSEASVFETDSDGSSGESSSEYSSSSDSEDERRRRRKAKKSKKKQKQRKERRRRYSSSSSESSESESASDSDSDEDRSRRKKKS 272
18 -10.200[U] COG3846 Type IV secretory pathway, TrbL components  ali follow..  8  33FDNILGRFHQVADTWSGEIVRYASWLFWSLALLSMVWTY-IRFFAVMGFFWWLLINAPAM-IIDSLRQIADIGFDITSKVIDDSSIRSPVNSAVGIIASTVILIVLALIGVNMLLLLVSGWLLSYGAVFLLGFGGGRWTSDIAISYYTVIGLGMQLFAMILIIYAAVSTGAITMKALLVMLVASIVLLA----------VNKIPPMFASIVGGGGATAGIGNFGAGAAIAAAATGAAVAATAGSALAAGLSSAGGGVSALKAAFQSAQQNMASGGGSGSGSGSGGNSAGVSSGGSSSFMSAMGTTGRFAADMGTSLAKGVGQVAKDKAGSVIASAKERVADTTGGKVA 416
19 -10.200[S] KOG4051 Uncharacterized conserved protein  ali follow..  16  205...................................................................................................................................................................................................................QKEPIKEVQSDEKELQREHMSEEEQKMKSTNKTAAPVRKSQRLKRSKEVKFEDEEKEEIEEDNTKDEEQKEKKEEIQEPKITHNEEVDKEKNENEEGDDEREKSTSYENTNGSESEGVDEGVDEELGYESEREAEGK 341
20 -10.200[R] KOG3362 Predicted BBOX Zn-finger protein  ali follow..  9  1.................................................................................................................................................................................MKIAQSKLF----------GKNRLSSKLFKNSYLNCRRNEANGMQPRSIEVGGRHFSDIKCAFSKLIFLFLSTILISKMFAPSRKPAATANQLRASSRISNLEGNRTLDENARRNRRNRQLDGLEQDNSHDDPHANLVWNKNAPKFDDEMIGGPSAKKAKKVKEDKSGIVH 162
21 -10.000[S] KOG4610 Uncharacterized conserved protein  ali follow..  6  168..................LP-LTRDQLSQLLLVYIGTAADIIEFFDSYKDDSIAKIGFLVFLTLGIWSWSLMQFTIVLSATRGRRPRGSGSHHKEEHTDCCQNCCCGIDVWGI-----------------------------------VLNVILQDAPFLTFRLLIIFQYKIINYMNVFFTCKNSLVIILQLYRLYVVNAEFWKNRRESRMAKSRQFQSRRKVQDADQNSIYMISNERGGDVKKKIKRAKDKDYAEQEAVYSKKKKDKKDKKKRKRKDTGYSTASSQNLYSTKASGTDKDTRRKDKKGKKSKRTCSSSPSDCDLAKKQKRKNADKNDKKKSRKIEAVV 464
22 -10.000[B] KOG2266 Chromatin-associated protein Dek and related proteins, contains SAP DNA binding domain  ali follow..  7  1..................................................................................................................................................................................................................MGEDTKATIEPTANKTTSLEKPSEAMAGKENAGGKETQELAKDEDMAEPDNMEIDAQIKKDDEKAETEDKESEVKKNEDNAETQKMEEKVEVTKDEGQAEATNMDEDADGKKEQTDDGVSVEDTVMKENVESKDNNYA 138
23 -9.950[A] KOG2202 U2 snRNP splicing factor, small subunit, and related proteins  ali follow..  8  163.....................................................................................................................................................................................................................NRGGYCNFMHVKLVSRELRRKLFGRYRRSYRRGSRSRSRSRSISPRNKRDNDRRDPSHREFSHRDRDREFYRHGSGKRSSERSERQERDGSRGRRQASPKRGGSPGGGREGSEERRARIEQWNREREEKEEGGA. 296
24 -9.910[T] KOG2289 Rhomboid family proteins  ali follow..  9  58................KKITGPNKECVARFLGRFSFQPLSTLEKMGALEWRKVVHEHQGWRLLSCMWLHAGI-IHLLTNMLSLIFIGIRLEQQFGFIRVGLIYLIILSSLFLQESISVGASGALFGLLGAMLSELLTNWTIYANKAAALITL------LFIIAINLALGMLPRVAHIGGFLTGFCLGFVLLVRPQYGWE..................................................................................................................................................... 252
25 -9.900[K] KOG2473 RNA polymerase III transcription factor (TF)IIIC subunit  ali follow..  6  230PTSNQWKWQVAVSALFEERPVWTRDSIVQRLLDKGLTCTHHMLNRFLLRAAYYFSGGP-FL-----------------RFWIKRGYDPRKDPESRVFQRMEFRV---------LKGYCDSNATNKSKPSWDDICAFKVFPFKCQTFLQLFELDDEYIQQEI------PPKQTTCNYKTGWFSEALLDNLRLRVAV-----------FVSVFPEPGFEDVFKSIQEEFERSEKTRIQKDALQPSQRNHQETTKDMKKCKNTNKEKDDDVNADEDSEDLDDEYEEAANDDDISISSHGYGDMENNSRTYLQGLFNRFPSSASALYGSANDDNDSDGEYPIYEQESNALDD 539
26 -9.710[A] KOG0113 U1 small nuclear ribonucleoprotein (RRM superfamily)  ali follow..  8  304...................................................................................................................................................................................................................RRDRRDRERERDRDREREKKKKRSKSRERESSRERRERKRERRDRERGTGSGGDVKERKPDFRDMDVIKIKEEPVDDGYPTFDYQNATIKREIDDEDEEKYRPPPAHHNMFSVPPPPILGRGNASTNPNPDNGQQSS 440
27 -9.670[C] COG0839 NADH:ubiquinone oxidoreductase subunit 6 (chain J)  ali follow..  13  3......SGLEAAFFYLFAFVAVASAFMVISSRNPVHSVLFLILTFFNAAGLFMLTGAEFLAMILLVVYVGAVMVLFLFVVMMLDVDFAEMKEGALQYAPIG--ALVGLILAAELIIVLGGYTFAPKLAATVSKPIPDLATRSNTAALGDILYTDYLYYFQISGLILLVA-------MIGAIV...................................................................................................................................................................... 169
28 -9.570[S] KOG2889 Predicted PRP38-like splicing factor  ali follow..  6  50..............................................................................................................................KGMDLRYIGGIYAGNIKPTPFLCLALKMLQIPDKDIVLEFIQQEEFKYIRALGAMSTEIYKYLEPLYKMGRFEAIYMDDFIDNLLREQKRWALEEVDMLPSYKSLLDGDLVAMSDSDSEEEEVTKKEKPRLTSRRRSRSRDRERDVGDRREVREREKLKERRERGDDEPGPSSSGSGRRDDRDDRRRDRDRSRDRDRRDRRDDDRRDKKKESRRGGADNDEE 300
29 -9.570[KB] KOG3265 Histone chaperone involved in gene silencing  ali follow..  9  203...................................................................................................................................................................................................................KIETEDLRVTTFPIRWTDEDPVAEPVDEEANKVFDEDDLMPLHDDGQDDDEEEEDDDETGPNTEEVDLNESFNERMANAHDGTEQKNGEESMEHDGASGDVEMGDNQLFVQINTDTKATESMVDPLSDTTKRDFRSG 339
30 -9.430[S] KOG2812 Uncharacterized conserved protein  ali follow..  7  133...................................................................................................................................................................................................................ERERIGELGAPEVWGLSPKNPEPDSDEHTPVEDEEPKKSTTSASTSEEEKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDSDSDSDSETDSSDEDNKRRAKKAKKKEKKKKHRSKKYKKKRSKKSRKESSDSSSKES 269
31 -9.240[S] KOG4852 Uncharacterized conserved protein  ali follow..  8  162..................................................................................................................................................................................................................................................................DEDDSDGPPADDEDDSNDEDNWRNDYPDEESYDEDSDNGDPYGISEPDHWHAGEEAYSDESFHRRLQNMDLNDERYEAFYEGDETDEDAD 251
32 -9.110[R] KOG4520 Predicted coiled-coil protein  ali follow..  8  128...................................................................................................................................................................................................................VGRVAMSREDKEAAKLGLSVFTHHRVESGGPGTSAASARRKPRAEDQTESSCESHRKSKKEKKKKKKRKHKKEKKKKDKEHRRPAEATSSPTSPERPRHHHHDSDSNSPCCKRRKRGHSGDRRSPSRRWHDRGSEA. 263
33 -9.000[S] KOG4102 Uncharacterized conserved protein  ali follow..  7  104............................................................................................................................................................................................................................ESSSSTDDECEHCFGHPEVRTRNRLEKQRIQEQQNGCSCCHHHHRLHSNRNNRPPTEEIAQHKDDLAKEEPKSVVNNESSLKLLNEENVKSSKPRFRRQRKAEENPLRKCSSVLVTQRAENRKKN... 228
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.