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Query: [Q] COG5310 Homospermidine synthase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLDKMANENWPVYGEITGPVVMIGFGSIGRGTLPLIERHFKFDKSRMTVLDPRDTDRKLLDERGIAFVQEAVTENNYKKLLTPLLTNGGGQGFCVNLSVDTGSVDLMRLCRKLGVLYIDTVVEPWLGFYFDAKADNASRTNYALREAMIKEKHDKPGGATVVSTCGANPGMVSWFVKQALVNLATDLGLEFSEPAQEDREGWAKLMKKAGVKGIHIAERDTQRTKKPKPMDVFWNTWSVEGFISEGLQPAELGWGTHEKWMPKNGKKHKHGSKAAIYLEQPGANTRVRSWCPTPGAQYGLLVTHNEAISIADFFTVRSKKGKVQYRPTCHYAYHPSNDAMLSLDEMFGAAGKPQPVHHVLDENELVDGVDELGVLLYGHDKNAYWYGSQLSLAEARKLAPYQNATGMQVTSAVLAGMVWALENPDAGIVEADEMDYKRCLDVQSPYLGPVKGYYTDWTPLDRRPGLFPEDLDRSDPWQFRNILVRLast
1 -116.000[Q] COG5310 Homospermidine synthase  ali  100  1MLDKMANENWPVYGEITGPVVMIGFGSIGRGTLPLIERHFKFDKSRMTVLDPRDTDRKLLDERGIAFVQEAVTENNYKKLLTPLLTNGGGQGFCVNLSVDTGSVDLMRLCRKLGVLYIDTVVEPWLGFYFDAKADNASRTNYALREAMIKEKHDKPGGATVVSTCGANPGMVSWFVKQALVNLATDLGLEFSEPAQEDREGWAKLMKKAGVKGIHIAERDTQRTKKPKPMDVFWNTWSVEGFISEGLQPAELGWGTHEKWMPKNGKKHKHGSKAAIYLEQPGANTRVRSWCPTPGAQYGLLVTHNEAISIADFFTVRSKKGKVQYRPTCHYAYHPSNDAMLSLDEMFGAAGKPQPVHHVLDENELVDGVDELGVLLYGHDKNAYWYGSQLSLAEARKLAPYQNATGMQVTSAVLAGMVWALENPDAGIVEADEMDYKRCLDVQSPYLGPVKGYYTDWTPLDRRPGLFPEDLDRSDPWQFRNILVR 485
2 -55.800[E] COG1748 Saccharopine dehydrogenase and related proteins  ali follow..  12  1...............MKKNVLIIGAGGVAQVVAHKCAQNSDVL-GDIHIASRTVDKCRKIVESEVKLEAHALDALDVEATKALI--VSTGSQIVINVGSAFVNMSVLRACMDTGVAYMDTAIH-------EEPNKICETPPWYGNYEWKRAAECKEKGITAILGVGFDPGVVNAYARLAKDEYFDK-----------------------------ITDVDIVDINAGNHGKYFATNFDPEINFREFTGVVYSWQKGAWQTNRMFEVGKEFD-------------------LPVVGKRQAYMTGHDEVHSLSKNMDGADVRFWMGFGDHINVFTVLKNLGLLSEQPVKTAEGLEVVPLKVVKAAPGYEGKTCIGDFVKGLKDGRFIYNVADHRQAYEEVGSQGISYTAGVPPVAAAMLIASGEWDVRQMANVEELPPRPFLDILNRIGLPTRIKDEQ............................. 405
3 -38.900[E] KOG0172 Lysine-ketoglutarate reductase/saccharopine dehydrogenase  ali follow..  9  471.......RAQSLSMGTRRKVLVLGSGYISEPVLEYLSRDGNI---EITVGSDMKNQIEQLGKKYNINPVSMDICKQEEKLGFLV----AKQDLVISLLPYVLHPLVAKACITNKVNMVTAS--------------------YITPALKELEKSVEDAGITIIGELGLDPGLDHMLAMETIDKAKEVGA---------------------TIESYISYCGGLPAPEHSNNPLRYKFSWSPVGVLMNVMQSATYLLDGKVVNVAGGINLEGYPNRDSTKYAEIYGISSAHTLLRGTLRYKG----YMKALNGFVKLGLINREALPAFRPEATQLEAAEWLGLLGDEQVPQAESILDALSKHLVMKLSYGPEEKDMIVMRDSPSGHLEHKTIDLVAYGDINGFSAMAKTVGLPTAMAAKMLLDGEIGAKGLMGPFSKEYGPILERIKAEGIIYT-TQSTIKP.......................... 926
4 -19.200[S] KOG2733 Uncharacterized membrane protein  ali follow..  10  1...............MSGDVIIFGAGFTGKYTVFEAVTVLR--GLRWGIAGRNREKLEAVLKE-SQVPIFIADVNDQASLLEMA----KKCRIVVNTAGPYHGENVVKCCIESGTHHVDVSGEP----------------QYMETMQLRYDQLAREKGVYVVSACGFDP--ADMGVVFVEKNFDGVVNSVETFLETGIKEGGSGGGTAGLNYGTWESAVYGLAHSDELRG------------IRKQIYPQRLPRFYPFLKPRPLVFRSTEVDKVCLPFPGSDRSVVMRSQRFLYDQDKKRPVQMQAYVGFSSWLVAGGVIFFATIFGLLSKFKLGRTL-LFSGGLASRSGPSEESME---------RTYFKMTFKASGWLKSDRLAESSNQYTEVRVSGMNPGYGATCVAVLSAALTILRESDKTGGVLPPAAFSKTGLISELEKHDHGIKFEILA............................. 428
5 -18.800[S] COG3268 Uncharacterized conserved protein  ali follow..  11  2...........SPDKREFDIVLYGAGFSGKLTAEHLALSES--TARIALAGRSSERLRNVRALAQDWPLIVADASQPSTLEAMA----GRAQVVLTTVGPYYGLPLVAACARTGTDYADLTGEL----------------MFCRNSIDLHHKQAAATGARIILACGFDP--SDLNVYQLYRRVIEDRTGELCDTDLVLRSFSQRWVSGGSVAAYSEAMLTTSNDPEALRLVTDPYTLTTDRDAEPDLGPQPDFPRHRGSDLAPELAGFWTGGFVQAQFNTRIVRRSNALQNWSYGRQFRYSETMSLGKSWAAPVASAAVTSVVAGAVGLGNKYFNRLPRRVVERVTPKSGTGPS-------RKTQARGHYTFETYTTTTTGARY---------MATFAHNVDAYKSTAGLLAASGLTLALDRDRLRGVLTPAAAMGEALLTRLPSAGVVIGTTRLS............................. 418
6 -14.200[S] COG3804 Uncharacterized conserved protein related to dihydrodipicolinate reductase  ali follow..  10  1...............MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAAELAGLADSTGVRASTDLNAVLAT--GPRCAVYNAMADNRLPEALEDYRRILAAGINIVGSGPVFLQYPWQVIPDEIIKPL-----------QDAARAGNSSLYVNGIDPGFANDLLPMALAGTCE------------------------SIEQIRCMEIVDYATYDSAVVMFDVMGFGKPMDQIPMLLQPGVL--------------------------SLAWGSVVRQLAAGLGISLDGVEEMYVREPAPEAFNIASGHIPKGSAAALRFEVLGL---VDGVPAVVLEHVTRLRADLCPEWPQPAQPGGSYRIEISGEPCYAMDICLSSRHGDHNHAGLVATAMRIAIPAVVAA---------EPGIRTTLDLP.................................................. 347
7 -12.800[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  12  3..................KIGIVGCGFIGGQICRAIDG--GEVSAELYLCDSSESKALELAA----------SLKTCKPSYMKIEELIRGVDLIIESASQNAVRFIVPQALKAGCDVM--------------ILSVGALADEELRDTLF--GLAKEHNCKLYFPSGAVVGI-DGLNSASAAGISSVT.......................................................................................................................................................................................................................................................................................................... 143
8 -12.600[R] COG4015 Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family  ali follow..  12  4ILLEISELEGKKAP--RGEVTLVGAGRLGLRTALNLMQIHRGGPERINVIDGQRKFIESLATPGFSRTVRGIPEYIDRDNLHLLRG--DVVCVEIAGGDTLPVAEIIKYAQKRGSATISTMGVFGIGEEEVNAISIEEADP-YLLDEGVTDHLLVGTGKLIRDWEPVTPYVLDRVSEVMTAEILKL........................................................................................................................................................................................................................................................................................................... 211
9 -12.400[Q] COG4569 Acetaldehyde dehydrogenase (acetylating)  ali follow..  11  1...............MSKKVAIIGSGNIGTDLMIKILRHGQHLE--AVMVGIDPQSDGLARARRMGV---ATTHEGVIGLMNM--PEFADIDIVFDATSAGAHVKNDAALREAKPDIR--LIDLTPAAIGPYCVPVVNLEANVDQLNVNMVTCGGQATIPMVAAV-ARVHYAEIIASIASKSAGPGTRANI...................................................................................................................................................................................................................................................................................................... 171
10 -11.300[E] COG4091 Predicted homoserine dehydrogenase  ali follow..  6  3LVGLARDLAARAETGKPIRIGLIGAGEMGTDIVTQVARMQGIEV--GALSARRLPNTFKAIRTAYGDEENARGATTESAMTRAIILSNPLIDVIIDATGIPEGAETGIAAIRNGKHLV------------------MMNVEADVTIGPYLKAQADKQGVIYSLGAGDEPSSCMELIEFV.................................................................................................................................................................................................................................................................................................................. 175
11 -10.700[E] KOG4777 Aspartate-semialdehyde dehydrogenase  ali follow..  8  2...............AIKKVGILGAGTVGQRFITLLSDHPEFKIAVLGASARSAGKPKWKQSIAMPKEISQMSVKACDP------KEFSECDIVFSGLDADFAGEIEKSFRDANLVIVSNAKNYRREPTVPLVVPTVNTDHLDVIKYQRQENKLDRGCIIT------NSNCSTAAVVVPLKALQDIAQTNVVSMQAISGAGYPGVS....................................................................................................................................................................................................................................................................................... 190
12 -10.500[E] COG0136 Aspartate-semialdehyde dehydrogenase  ali follow..  12  1MACGVPEAERDRRRKMGFKVAVAGAGNVGREMLNILEER-GFPADEVVPLASRRSQGTEVSYGDKTLKVRALDTYDFSDT-----------DICLMSAGGSVSQEWSPKIGRQGCVVIDNSSAWRYDADVPLIVPEVNPDAI---------AGFTKKNIIA------NPNCSTAQLVVALKPLHDIKRVVVSTYQSVSGAGKEGMD....................................................................................................................................................................................................................................................................................... 185
13 -10.300[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  11  1.................MQLGMIGLGRMGANIVRRLAKGG-----DCVVYDHDPDAVKAMAGEDRTTGVASLRENITTAVIEELANTLEAGDIVIDGTYYRDDLRHEKLLFKKGIHLLDCGTSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGSEQGYLHCGCGSGVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPLPNPECYQYDFDIPEVAEVWRRGSVIGSWLLDLTAIALRESPDL......................................................................................................................................................................................................................................... 273
14 -10.300[MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases  ali follow..  11  30...........TLANLPPLVTVFGGGFVGRHVVRMLAKRG----YRIRVAVRRPDLAGFLQPLGGQISFAQANLRYRDSIIKAV----EDADHVVNCVGILAESAIAEAARDTGATLTHISAIGADANSQTGYGRTKGRAEAAIHSVNKFAKMARNLPFLPLIGGGFQPVYVEDVAEAVARSVDGKLKP........................................................................................................................................................................................................................................................................................................ 239
15 -10.100[E] COG0345 Pyrroline-5-carboxylate reductase  ali follow..  10  3................NQKIGFIGAGKMGSALMQGTIKAGIVTPENIGASDVYEPFLKDLQAKESDILILAVKPQTLSSVLSNLKNEITSEKLVISIAAGVPGTRVVRVMPNIAATVSEAASGIAPGKNATPEDLKAALEIFSAVGTAVQVPESLMDAVTGLSGSG--PAFIFPVIEAMAD................................................................................................................................................................................................................................................................................................................ 189
16 -10.100[H] COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1  ali follow..  10  35................AAHVCVIGIGGVGSWAVEALARTG---IGELTLIDMDEVMAERVKLINPECKVNLVDDFITPDNQHLYLN--KSFDYVLDAIDSLKAASLLAYCRSNKIKVITVGGAGGQTDPTQITVADLTKTDRLRQHHNFPTNPARKFGIDCVFSATVVTATFGFVVARIVDKLIQKHKV........................................................................................................................................................................................................................................................................................................ 271
17 -10.100[H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2  ali follow..  9  126..RQALAFGEALNQDLSMRVGVIGCGGTGSAIAMLLPK---MGIRNIALFDKDSPKVEVVAKSLVELGLVQVRTYQAWIGEADCRDPLKACDVIFCCTDDHTGRLMLRFAYYYATPVFDMGLAIEVSQGETPNFQNPVIARDEALKRSNPDEYERRKAEAYVIGEG-SPAVVLFTTEVAIMAMQELVHR........................................................................................................................................................................................................................................................................................................ 358
18 -10.100[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  10  1............MSHTKPSIAILGAGRVGSSLARSAVAAGY----EVKVAGSGAVDKIALTAEILMPGAVPSTADQ----------AVKDADIVFLAVPLHKFRSVNPATLE-GKIVIDTMNHWVPVNGELEEIDQDPRSTSEIIAEFF-DVDAGAQVAQLIKSFGFVPG........................................................................................................................................................................................................................................................................................................................... 177
19 -9.910[E] COG0289 Dihydrodipicolinate reductase  ali follow..  9  1...............MTLKIAIAGAGRMGCQLIQAVHSAEGV---ELGAAFERKGSSLVGTDAGELAGIGHLGV----AVSDDLESQKDKFDLLIDFTRPEGTLEHIAFCVANNKKMV------------------IGTTGFDENGKVAIKAASDKIAIVFASNFSVGVNLVFKLLEKAAKVMGDYCDIEVIEAHHRHKVDAPS......................................................................................................................................................................................................................................................................................... 165
20 -9.770[E] COG0002 Acetylglutamate semialdehyde dehydrogenase  ali follow..  13  2..................KVGIIGAGYTGGELLRLLVSHPDV---RLELATSRSLAGKPVSSTHRHLT----GFLDLKYENPVSEEIRERCDVVFVAVPHGTAMNYVPELLDGSTKVIDLSAD-DTPVFENIYGIKHSDPRKAVYGLVELHPEAAREEFVA------NPGCFPTGANLAAAPLAAAGLIDIAVFDSKTGISGAGISPTETSHYPNIAE........................................................................................................................................................................................................................................................................... 191
21 -9.440[Q] KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali follow..  11  29TRRYFKGGQFNERVSAKGLVAVVGSNGIGFETVRELNLRK----ADVYMLCRSEEKANEAKRMATRLHFIECDLTDFESVAKETLESTDTIDILINNAG-LLTELFLPAVKKSSARIINVSSRIHLKSEKINLATVDDKKSFGMMKSYALTKELRKDGAEHVTVNSLHPGVVNT....................................................................................................................................................................................................................................................................................................................... 248
22 -9.430[H] COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)  ali follow..  12  1......MRYFPLFLDLTKPVLVVGGGEVACRKIDALLRADA--KVTVISPQVAPALQAWIEQGKCHWIQHFYSSHWLDKRYVQVWATTDNPEL---------NHQVYKDAKEQGI-LVNVV-------------DDQPYCDFITPSMIERGR------QLAISSGGASPVLIRNIRETLEAVLAQ............................................................................................................................................................................................................................................................................................................ 150
23 -9.350[Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related dehydrogenases  ali follow..  15  2...........ESGDESPVVLITGCGGIGHALAREFTEKG-----RVVATSRSRSTMTDLEQDS-RLFVKELDVQSDQNVLSEVIDKFGKIDVLVNNAGVQCVGPLAETPISAMENTFNTNKDLIFSFNYYIYWSFNSSGSMRMTQAVVPHMVSKKKGK--IVNVGSITVMAPGATKAAIHALTDTLRLEL...................................................................................................................................................................................................................................................................................................... 190
24 -9.330[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  13  2.................ETIGFIGLGIMGAPMAGHLLDAG-----KVIASDHRSKPLADLVAKGLKTVSGHAAVAKAADIINGVASGLTRGKLVIDMSSPIETKVFAGKINELGCDYLDAPVSGGEVGAKAASLTIMVGGEEKAFERAKPVFEKMGKNITLVGPNGVGQ-ANQIVVALTIEAVAEALVF........................................................................................................................................................................................................................................................................................................ 191
25 -9.270[I] KOG1478 3-keto sterol reductase  ali follow..  8  1...............MRKVVLITGASGIGLALCKRLLAEDD--ELHLCLACRNMSKAEAVCAATAEVTIVQVDVSNLQSVSKELKQRFQRLDCIYLILIRELEPLLCHSDNPSQLIWTSSRSARKSNFSLEDFQHSKGKEPYSSSKSVALNRNFNQQGLYSNV---ACPGTAL........................................................................................................................................................................................................................................................................................................................ 227
26 -9.170[Q] KOG1204 Predicted dehydrogenase  ali follow..  9  1...............MGKVILITGASGIGLQLVKTVIEED----DECIVYGVARTEAGLQSLQADKFVYRVLDITDMEALVEEIRQKHGKLDGIVA------NAGMLEPVKSISQSNSEHDIKQWERLFDVNFFSIVSLVALCLPLLKSSPFVGNIVFVSSGASVKPYNGWSAYGCSKAA................................................................................................................................................................................................................................................................................................................. 163
27 -9.170[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  9  1...............MSADFGLIGLAVMGQNLILNAADHG-----TVCAYNRTQSKVDHFLANEAKVMLLVKAGAPVDALINQIVPLLEKGDIIIDGSHFPDSNRRYEELKKKGILFVGSGVSGGEEGARYSLMPGGSEEAWPHIKNIFQSISAKSDGEPCCEWVGAGAGVHNGIEYGDMQLICEAYDI........................................................................................................................................................................................................................................................................................................ 202
28 -9.150[R] KOG4288 Predicted oxidoreductase  ali follow..  12  1.................MKIVVLGSGFLGHNICKLAIAKG-----EVVSVSRRGAGGHNKEPWMDDVEWETLDAQKDPNSLLPVL---RDASAVVNSVGILMAIETAKIAAKANVPYCYVSAHA---------AAPGLDPRYIKTKREAEREISKISNLRSIF---LRPGFM......................................................................................................................................................................................................................................................................................................................... 196
29 -9.040[H] COG1635 Flavoprotein involved in thiazole biosynthesis  ali follow..  8  19..........TFLDYTDIDVALVGGGPANLVAAKYLAEAG-----KVALYEQKLSLGGGMWAGGMMFPRIVVQEEATRILDDFGIRYKEYESGYYVANSVESVGKLIAGATSAGAEVFNLVSFEDIMIRENDRVTGIVINWGPVTTQRLHVDPLMIRTKLVIDGTG-----EAVVCNTILRKIPNAK.......................................................................................................................................................................................................................................................................................................... 187
30 -9.020[C] KOG2865 NADH:ubiquinone oxidoreductase, NDUFA9/39kDa subunit  ali follow..  12  63...........RSSVSGIVATVFGAGFLGRYLVQQLAKMG----SQVLVPFRGSEDSPRHLKL-GQVVPMKFDPRDEDSIKAVM----AKANVVINLIGREYAEKLALVCEHGGIRYIQVS----------CLGASVSSPSRMLRAKAAAEEAVLNALPEATI---MRPATM......................................................................................................................................................................................................................................................................................................................... 221
31 -9.020[E] KOG4354 N-acetyl-gamma-glutamyl-phosphate reductase  ali follow..  10  4.EAQKTQKPLKAVSSKPAKVVLLGAGYTGKNLIGLINTHPYLELSHVSSRELEGTKLPGYTKKEIQYVNLSTDDVKKLEEEGAV-------DAWVMALPNGVCKPYVDALTSANSVIVDLSAD------------RFEPSWQYGLPELNDREALRNSKRIS------NPGCYATGSQVGLTPILSLIDGQPSIFGVSGYSGAGT......................................................................................................................................................................................................................................................................................... 185
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.