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Query: [R] COG5322 Predicted dehydrogenase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNPSTAPKTMKFGFIAHPTSVALKRHVKIVDLLERTIAEQDRGYRDDRWQWRNLVPFADFGRIVSAQGAVCEGILHYMPLTAEEMLSQPRAIAQRVVDAVESLKDQGAQVVGLGGFTAIVGNRGLQTLERTGIPVTTGNSLTAYAAYRNVLESMDRLGVEPADTEVAVVGYPGSIALVIAKLLAGHGCRLCLVHRGSEAQGRQGLAYLPEPMHAQVRLSNDIEHCYEHVQFYVAATSTGGLIDPYRLRPGSVVVDAALPRDVKPYRKDRNDILIIDGGLVSASSALRFGAESMGLAPKKFLNGCLAETLILGLEGRAEAFSIGRELPEDKVLEIGRIAELHGFSPSPMASYGEPVKDRHFAALRPFHRPRTQSPAGLLast
1 -79.300[R] COG5322 Predicted dehydrogenase  ali  100  1MNPSTAPKTMKFGFIAHPTSVALKRHVKIVDLLERTIAEQDRGYRDDRWQWRNLVPFADFGRIVSAQGAVCEGILHYMPLTAEEMLSQPRAIAQRVVDAVESLKDQGAQVVGLGGFTAIVGNRGLQTLERTGIPVTTGNSLTAYAAYRNVLESMDRLGVEPADTEVAVVGYPGSIALVIAKLLAGHGCRLCLVHRGSEAQGRQGLAYLPEPMHAQVRLSNDIEHCYEHVQFYVAATSTGGLIDPYRLRPGSVVVDAALPRDVKPYRKDRNDILIIDGGLVSASSALRFGAESMGLAPKKFLNGCLAETLILGLEGRAEAFSIGRELPEDKVLEIGRIAELHGFSPSPMASYGEPVKDRHFAALRPFHRPRTQSPAGL 377
2 -20.500[H] COG0373 Glutamyl-tRNA reductase  ali follow..  13  65.........................................NKVIEWLSQFHQVSLDELKPSLYVHEEQAAIRHLMRVACGLDSLVLGEPQILGQVKQAYAEARENHAVNPATEKLFQKAFSVAKRVRTETEI------GGSAVSVAYAACTLAKHIFESLADATVLLVGA-GETIELVAKHLAGHHCKRMIVANRTRE----RALSLAQQFGADVIALNEIPDYLAQADIVISSTASPLIIGKGMVESPMLLVDIAVPRDIEPQVGKLNDAYLYSVDDLQSIVDSNIEQRKVEAIQAEAIVSEESATFMSWMRSLQAVDSIRDEAREELLNKSLQALAAGGDPEKLLIELSNKLTNKLIHTPTRALQTAAEQGEP. 403
3 -13.200[H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase  ali follow..  17  88..................................................................ADKNIDGILVQLPLPKQ---------AEAIIERIDPKKDVGFHPYNVG-------------------RLCQRIPTLRACTPYGVMKLLETTGIDLHGKHAVIVGASNIVGRPMSLELLLAGATVTVTHRF----------------------TKNLENHVRQADILVVAVGKPNLISGDWIKESAVVIDVGINREFDKAAEKAAYITPVPGGV.................................................................................................. 262
4 -12.200[H] KOG0089 Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase  ali follow..  19  116..................................................................NDDNVDGLLVQLPL-PEHI-------ERRICNAVSPDKDVGFHVINVG-------------------RMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTP------------KEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRDFEGVRQKAGYITPVPGGV.................................................................................................. 306
5 -11.400[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  13  1..............................................................................................................................................................MSHTKPSIAILGA-GRVGSSLARSAVAAGYEVKVAGSGAVD----KIALTAEILMPGAVPSTADQAVKDADIVFLAVPLHKFRSVNPATLEGKIVIDTMNHWVPVN-----GELEEIDQDPRSTSEIIAEFFAGSTMVK---SFNHIGYHEIEQDAGTGRAIAYATD-DVDAGAQVAQLIKSFGFVPLNI............................. 176
6 -11.400[H] KOG4230 C1-tetrahydrofolate synthase  ali follow..  15  88..................................................................EDPTVHGIIVQLPLPAH---------EQIITEAVAPEKDVGFCETNLGKLT-----------------KREGQPLFTACTPKGIMCILKHYGINVQGKHAVVIGRSNIVGRPMSILLEKANATVTLCHSK----------------------TESIADIVRTADIVVAAIGIPHFVKADWLKKGVVAIDVGINSDFENAKEVASAITPVPGSV------------------GPMTVAMLLQNVVESAVRFRKMSRVPSDIEIARPKNIGDLASEIGIAKSELEFYGSHKAKVNLEILQRLAHRRDGH.... 364
7 -9.770[E] COG0169 Shikimate 5-dehydrogenase  ali follow..  12  2.....ASQIDQYAVFGNPINHSKSPFIHTLFARQ----------QSMIYTAQCVPVDGFTEAAKHFFAQGGRGCNVTVPF----------------EEAYRFADRLTERARLAGAVNTLKKLDDGEILGDN----TDG---------EGLVQDLLAQQVLLKGATILLIGAGGAARGVLKPLLDQQPASITVTNRTFAKAEQLAELVAAYGE----VKAQAFEQLKQSYDVIINSTSASPAIDPVIFSSRSVCYDMMYYTVFNQWARQHGCAQAIDGGMLVGQAAESFMLWRGLRPGTKQILRELRKNLEGAL................................................................ 278
8 -9.300[G] KOG1203 Predicted dehydrogenase  ali follow..  11  54......................................................................................QQVSHSLELRSYRKRVTAKSGSQGWDFGRFVKTLYFFN-----------SPLKFVSSVFEKLTNGATEEPVAEMGTSGIILVAGATGGVGRRIVDILRKRGLPVKALVRNEEKARKMLGPEIDLIVADITKENTLVPEKFKGVRKVINAVSV........................................................................................................................................... 197
9 -8.950[E] KOG3007 Mu-crystallin  ali follow..  11  59...............................................................................................IMPCWIPGKFLGVKQVNVSHYLLSDATTGCHLAQLDGNELTS----TAAASALASSYLSKE-----DSTSLLIIGS-GKVAEKLIHAHVRPIRSVRIWNHRFESAKSLASRASKESIQIDAVPIQNLENAVKCSDIISSATSKKPIIVGSWINPGTHIDLVGG-HEADSKCIQISNVFVDTRKGALHEAGDLLTPIKEGLFSPNEVIADLFDLCNNKHSGRSQLKNPAEAIT---------LFKSVGDSREDL............................. 316
10 -8.910[CHR] COG1052 Lactate dehydrogenase and related dehydrogenases  ali follow..  12  59................................................................................................DEVYDYMGACKLKVLSTRTAATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHAREILSKELRCSRVGILGT-GRIGQAAARLFKGVGAQVVGFDPYPNDAAKEWLTYV------------SMDELLSTSDVISATKDSHHLINAKTIKDGVYLVNTARGAVIDSQA-----LDSLDKGKIA................................................................................................ 254
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Rychlewski L, Godzik A. Improving the quality of twilight-zone alignments. Protein Sci. 2000 Aug;9(8):1487-96.