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Query: [U] COG5325 t-SNARE complex subunit, syntaxin, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAYRDRTGLYITFRQSYSHHGQRLELSGWDPKEERQSLVHKDNKDNTVIEMDMLAPRWVTVEGEIDSLLLNTRRNINLLDKQYAKHVLPSFSDKTEQENEIQRLTIQITQDFQRCQKLLQVTKAQTNSATGSEALMAKNFLSNLASRIQTESAQFRKKQSTYLKKLRGLNANISPVESKLDETVSDVAISQSTIQQVALMEEQGEDEQAIRHERAVAKIAEGIIELAQMFQDLQVLVIEQGALVDRIDFNIEQTQVHAKSAEKELIKAESHQKNTGRLRFICFLILLIVALIVILAIKLLRLast
1 -83.500[U] COG5325 t-SNARE complex subunit, syntaxin  ali  100  1MAYRDRTGLYITFRQSYSHHGQRLELSGWDPKEERQSLVHKDNKDNTVIEMDMLAPRWVTVEGEIDSLLLNTRRNINLLDKQYAKHVLPSFSDKTEQENEIQRLTIQITQDFQRCQKLLQVTKAQTNSATGSEALMAKNFLSNLASRIQTESAQFRKKQSTYLKKLRGLNANISPVESKLDETVSDVAISQSTIQQVALMEEQGEDEQAIRHERAVAKIAEGIIELAQMFQDLQVLVIEQGALVDRIDFNIEQTQVHAKSAEKELIKAESHQKNTGRLRFICFLILLIVALIVILAIKLLR 301
2 -73.400[U] KOG0809 SNARE protein TLG2/Syntaxin 16  ali follow..  29  1MATRNRTLLFRKYRNSLRSVRAPLSSSSNPNRSYAPISTEDPGTSSKGAITVGLPPAWVDVSEEISVNIQRARTKMAELGKAHAKALMPSFGDGKEDQHNIESLTQEITFLLKKSEKQLQRLSA---SGPSEDSNVRKNVQRSLATDLQLLSMELRKKQSTYLKRLRQQKEDGMDLEMNLSRNRYRPEEFGDMLNEHQMSKIKKSEEVSVEREKEIQQVVESVNDLAQIMKDLSALVIDQGTIVDRIDYNIENVATTVEDGLKQLQKAERTQRHGGMVKCASVLVILCFIMLLLLILKEI. 320
3 -62.100[U] COG5074 t-SNARE complex subunit, syntaxin  ali follow..  15  28.................................................AEGHDFVGFMNKISQINRDLDKYDHTINQVDSLHKRLLTEVEEQASHLRHSLDNFVAQATDLQFKLKNEIKSAQR-----DGIHDTNKQAQAENSRQRFLKLIQDYRIVDSNYKEENKEQAKRQYMIIQPEATEDEVEAAISDVLNANRRGEAKTALAEVQARHQELLKLEKSMAELTQLFNDMEELVIEQQENVDVIDKNVEDAQLDVEQGVGHTDKAVKSARKARKNKIRCWLIVFAIIVVVVVVV.... 281
4 -61.500[U] KOG0810 SNARE protein Syntaxin 1 and related proteins  ali follow..  14  2...RDRLPDLTACRKN------------------------DDGDTVVVVEKDHFMDDFFHQVEEIRNSIDKITQYVEEVKKNHSIIL-SAPNPEGKIKEELEDLNKEIKKTANKIAAKLKAIEQSFDQRTSVDLRIRRTQHSVLSRKFVEAMAEYNEAQTLFRERSKGRIQRQLEITGRTTTDDELEEMLESGKPSSDSQITRQALNEIESRHKDIMKLETSIRELHEMFMDMAMFVETQGEMINNIERNVMNATDYVEHAKEETKKAIKYQSKARRKKWIIIAVSVVLVVYRLFGLS... 283
5 -58.400[U] KOG0812 SNARE protein SED5/Syntaxin 5  ali follow..  15  8SSYRDRSDEFFKIVETLRRSIAPAPAANNVPYGNNRNDGARREDLINKSEKRIRMVLRSRTDLFSGVNFSSAYLSTRECVIVAKRTSV------DDPTQEIQELTVVIKQEISALNSALVDLQLFRSSRDRDKSTHSATVVDDLKYRLMDTTKEFKDVLTMRTENMKVHESRRQLFSSNEGESSPLLQQSQQQQQQQQQQMVPLQDTYMQGRAEALHTVESTIHELSSIFTQLATMVSQQGEIAIRIDQNMEDTLANVEGAQSQLARYLNSISSNRWLMMKIFFVLIAFLMIFLFFVA... 377
6 -57.600[U] KOG0811 SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17  ali follow..  15  23......................................................GGSRQDTTQDVASGIFQINTSVSTFHRLVNT--LGTPKDTPELREKLHKTRLYIGQLVKDTSAKLKEASETDH--QRGVNQKKKIVDAKLAKDFQAVLKEFQKAQRLAAERETVYAPLVHKPSLPSSYTSSEIDVSKRQELVLLDNEIAFNEAVIEEREQGIQEIQQQIGEVHEIFKDLAVLVHDQGNMIDDIGTHIDNSYAATAQGKSHLVRHQRHKDQILL........................ 255
7 -32.400[U] KOG3894 SNARE protein Syntaxin 18/UFE1  ali follow..  8  2SRFRDRTEDFKDSVRNSAVSIGYNESKVASTMASFII------------HKPKERSPFTKAAFKTLDSIKELELFMLKHRKDYVDLHRTTEQEKDSIEQEVAAFIKACKEQIDILINSIRNLGLPADNFNADSIAHKHGVVLILSEKLHSVTAQFDQLRATRFQDIINRAMPRRKPKRSIEPDEIQAQPRRLQQQQLLDDETQALQVELSNLLDGARQTETKMVEMSALNHLMATHVLQQAQQIEFLYDQSNDD-RNLEAINASVGR.................................. 279
8 -24.500[U] KOG3202 SNARE protein TLG1/Syntaxin 6  ali follow..  11  3.......................................................DPFYEVKADASNQMEQVRKLYNSFMAARNS-------GVLSPNTELTYAIDELSETLKDLKAAVEIAMKNSEHFGLDEEELKSR-------------RRFVSELDIELNNIQLKMGAAPSTPVSTEPYTVDNGASAGLSEEDHAVNRQYQEQLYQQQDVMLDGVYDTIGNIRGQAALMGEELGQQADLLDTLDNSIETTNSKLRRGMKRLKDFTIASADSKSGCCITVLIIILIALLVLVI..... 223
9 -16.400[U] KOG3385 V-SNARE  ali follow..  11  29..........................................................................................................................................................................................................YSHEINEHENERALEGLQDRVILLKRLSGDINEEVDTHNRMLDRMGNDMDSSRGFLSGTMDRFKTVFETKSSRRMLTLVASFVGLFLVIYYLT...... 121
10 -16.000[U] KOG3251 Golgi SNAP receptor complex member  ali follow..  9  2.........................................................SNTLYNHCTKLFQSIQRSLDELERGVQ---------DESNTISLAGIQGQISASFLSLSRSIDDYDSMQRELVPAKKKKATIRIQEFRQKHVQLLEKFDELKAHVRDIAQAKNRKELLGRRGYVNSLDSPYGNSTTDAEIVEGPSDLSRQDGLLKEHDLGRAESQVDEFLERGRMILGDLVEQGSVLKATKTKVLNAANTLGITRHTLSLI---NRRSKQDKIIFYCGAFLVFVLFYLIYRWLR 235
11 -15.900[U] KOG1666 V-SNARE  ali follow..  12  2................................................ASSAASSEHFEKLHEIFRGLHEDLQGVPERLLGTAGT-------------EEKKKLIRDFDEKQQEANETLAEMEEELRYAPLSFRNPMMSKLRNYRKDLAKLHREVRSTPLTATPGGRGDMKYGIYAVENEHMNRL----------QSQRAMLLQGTESLNRATQSIERSHRIATETDQIGSEIIEELGEQRDQLERTKSRLVNTSENLSKSRKILRS---MSRKVTTNKLLLSIIILLELAILGGLVY... 225
12 -15.400[U] KOG3065 SNAP-25 (synaptosome-associated protein) component of SNARE complex  ali follow..  13  48...........................................................EVLRRAEATAASTSRSLALMYESEKVASSEELARQRGVLERTEKMVDKMDQDLKISQKHINSIKSVFGGLVNYFKSKPVETPPEQNGTLTSQPNNRLKEAISTSKEQEAKYQASHPNLRKLDDTDPVPRGAGSAMSTDAYPKNPHLRAYHQKIDSNLDELSMGLGRLKDIALGMQTEIEEQDDILDRLTTKVDKLDVNIKSTERKVRQ.................................. 257
13 -13.100[U] KOG3208 SNARE protein GS28  ali follow..  9  2....................................................DVPSSWDALRKQARKIEAQLDEQMHSYRRLVSTK------ALSKSDGNESDLEAGIDLLLRQLQQVNAQMQAWVSSGGSEMVS-------HTLTRHQEILQDLTQEFYRHRSSLRAKQEHA----------SLLEDFREFDRTRLDLEDGYGSEQALIKEHMGINRNTAQMDGVISQAQATLGTLVFQRSTFGGINSKLSNVASRLPTVNTILAAIKRKKSMDT----IILSLVAAVCTFLIFIYWITK 223
14 -11.700[S] KOG2678 Predicted membrane protein  ali follow..  11  1............................................................MATKLNVNIRTLLANCEELAK------------SEQNFWRLQKFIKSLDTMLAELEERLQALKISTGYADVPGSTTKTPSQSSAVSETGENALKEIRQLQNSKYHNELRKELLQDSDALRRRRGADESSSSSGSANVQETSGENMNQAAKYYTNAQEKITEHMLSLTRNLKEANRIIRRDTEVVSRSAGMADRNINSLGKEAEKLEQHSK--KAYKCWLWLMIAFVIATFIGMVLFMKIMK 246
15 -10.300[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  8  688...TQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLDHI.................................... 962
16 -9.920[U] KOG0860 Synaptobrevin/VAMP-like protein  ali follow..  17  24..................................................................................................................................................................................................................QSKSRTAELQAEIDDTVGIMRDNINKVAERGERLTSIEDKADNLAVSAQGFKRGANRVRKAM---KDLKMKMCLALVIIILLVVII..... 108
17 -9.750[R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein)  ali follow..  10  398........................................................................GDKLEGIKLEYTLLLTSQLEDQRK-EGLRHDMEQTMSKMEKTAYAQVENLEHQLTERSTELKSLKGDL-DDTVTARKVAEKRATQTNEKVNKLANELKDERE---------------INQMLRKDQQVWKGQVEKLIESQKTARTEYEKKIEDLQSQVNDLLMHFETQNKLKEQLDAG-KITQEEITESQVELDSSSSSSRKLNRKK...................... 588
18 -9.670[S] COG4372 Uncharacterized protein conserved in bacteria with the myosin-like domain  ali follow..  12  23..............................................................DHLGSKVGKARLRLFKLRPRQSKSLREGVFQLDDILAQLRVAKTELEQASQAKEEIESELTAVREEQQLVQERSRNRNYTKALQLLRRVSEQSRNLRQEVANLSAERAQLNEQKDSLLAESSELQSQVKLRDQEKRQERIAQQEKVLARQREQVQSLEKRFASLEAQRQQLQAEINQRDTKIDQLDQAIAAKDNDIQAREEKLQGLETELSFLQRE....................... 266
19 -9.630[U] KOG3838 Mannose lectin ERGIC-53, involved in glycoprotein traffic  ali follow..  9  236.........................................................ISAATGGLADDHDVFHFLTTSLHAAGQVQEQPKVENQEKLTQEYKEYQDKLEKQKQEYKKDHPDEHKDEEDWEEFYESENQRELRQIWQGQSQIADHLRELSRKVDEIIGRQETTLSLVSRNAGQALPPPAAGGVPQQQVSRSDVDLLLTNQNMLLSSIREIRQLVGDINVRTDNIQSTGYDVQTLIAEMRDGMNQVKQGITHVGQRLAAPQGAAQVAGVTLFLSVTVVQLLLVFIYNVFKNRS 504
20 -9.300[UR] KOG4677 Golgi integral membrane protein  ali follow..  10  226...........................................................DQKEKAVEECNMHKRKIVGLEE-MVEQLRLAKFNLNENKKEFDEYKNKAQKILTAKEKLVESLKSEQGIGSSVERDLTKADLESAQLQVYTLRSDMEELEAQIRDLQSQLSDQKRTHLEEKQTWDSTIGLLNEKTKQEMKRQGDQHQSKMLEKENELRKTISDLRQEDDGSSQLTDLLLQKQQQLEDVLRNNQVLNVRLERLQKATNRETSIAVDS.......................... 478
21 -9.090[U] KOG0859 Synaptobrevin/VAMP-like protein  ali follow..  13  125.................................................................................................................................................................................................................PDEISKLAKVKAQVSEVKGVMMENIEKVLDRGEKIELLVDKTENLRSQAQDFRTTGTQMRRKM---QNMKIKLIVLAIIIALILIIVL.... 211
22 -9.030[S] COG5293 Uncharacterized protein conserved in bacteria  ali follow..  13  265...........................................................ERVNFLTSQIHEATNKNITDQKLLEFYQSSLKSEDEPRPDDIVSIYENAGIELGLVVRRLEEVEIFHRRLIENRREFLGSEIKRLRRDLVSRENFIREKSNERAELLEVLKTHG------------------------ALEEYTMLQEIYLDNVANLNEINKRIEELKQFEEERSSLKIEKELLLQRARRDYGERNEQAERAIDLFRINSR............................... 452
23 -9.020[U] KOG0862 Synaptobrevin/VAMP-like protein SEC22  ali follow..  9  130..................................................................................................................................................................................................................RARRNLGSINTELQDVQRIMVANIEEVLQRGEALSALDSKANNLSSLSKKYRQDAKYLNMRS---AKLAAVAVFFIMLIVYVRFWWL.... 215
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Schwarzenbacher R, Godzik A, Jaroszewski L. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. Epub 2007 Dec 5.