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Query: [T] COG5408 SPX domain-containing protein, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKFGKTFANHRIPEWSSQYVGYKSLKKMIKEITRLQEDIYRAHNKNSYDEGRPPTKMRDSSNSAQNYLDSPKIQKLLASFFFAVDRDIEKVDTFYNSQYAEYKKRFERLLSSNQFNEIKSTLVVDANKEDAVAQTLLTKDTREMNMLLKGTSQASRLSYHKDDLIEIQSILAELRKQFRNLKWYAELNKRAFGKILKKLDKKVGTNQQMSTMKTRILPLQFANDSLITKDLSLLKTIWEQVTFRINSYERVMRSTSPNANANDNTEFFKIICVFIEEDDSKGLIRELTNLYSELSLIPTRLast
1 -106.000[T] COG5408 SPX domain-containing protein  ali  100  1MKFGKTFANHRIPEWSSQYVGYKSLKKMIKEITRLQEDIYRAHNKNSYDEGRPPTKMRDSSNSAQNYLDSPKIQKLLASFFFAVDRDIEKVDTFYNSQYAEYKKRFERLLSSNQFNEIKSTLVVDANKEDAVAQTLLTKDTREMNMLLKGTSQASRLSYHKDDLIEIQSILAELRKQFRNLKWYAELNKRAFGKILKKLDKKVGTNQQMSTMKTRILPLQFANDSLITKDLSLLKTIWEQVTFRINSYERVMRSTSPNANANDNTEFFKIICVFIEEDDSKGLIRELTNLYSELSLIPTR 300
2 -55.200[P] KOG1161 Protein involved in vacuolar polyphosphate accumulation, contains SPX domain  ali follow..  20  1MLFGVKLANEVYPPWKGSYINYEGLKKFLKEDSVKDGSNDKKA---------------------------RWDDSDESKFVEELDKELEKVYGFQLKKYNNLMERLSHLEKQTDTEAAIKA----------------------------------------LDADAFQRVLEELLSESTELDNFKRLNFTGFAKIVKKHDKLYPKYPSVKSLLEVRLKELPSHSEEYSPLLYRISFLYNILRSNFNTASEPLASASKFSSSNDIDMNFRSFKFWVHNDNLMEVKTRILRHLPVLVYANVP 235
3 -49.900[P] COG5036 SPX domain-containing protein involved in vacuolar polyphosphate accumulation  ali follow..  19  1MKFGQLLKETLMYEYKYSYVNYDKLKKEIKRRNDQGGWS----------------------------------EEDESDFVELLEKELDKVYSFQKNKSAEVMERIRFCEEQTDEVVRRLD---------------------------------SDNPPNENDFAILETELTDIMATVHDLAKFSELNYTAFYKIIKKHDKHTGWILKPVFAAR-LNAKPFFKEQ-YDLLVVKLSKLYDFVRTRGSPIKG-----DSAAGGTQQNFVRQTTKYWVHPNNVTELKIYILKHLPVLVFNPNK 226
4 -49.600[U] KOG1162 Predicted small molecule transporter  ali follow..  20  2VKFSKELEAQLIPEWKEAFVNYCLLKKQIKKIKTSRKPKPASHYPIGHHRGSSETGDDVDEIYQTELVQLFSEEDEVKVFFARLDEELNKVNQFHKPKETEFLERGEILKKQLETLAELKQILSDRKKRNLSGSNSHRSFSSSEELVNNPRSDFTNWKNIQSAEKKIRSAFVELYRGLGLLKTYSSLNMIAFTKIMKKFDKVAGQNASSTYL-KVVKRSQFISSDKVVRLMDEVESIFTKHFANNDRKKAMKFLKPHQTKDSH..................................... 383
5 -17.600[O] COG5574 RING-finger-containing E3 ubiquitin ligase  ali follow..  14  1...........MPGWGEAAIQYKALKKCIKRFVFELSSSASSQSVETCETVDEDIDTQTMSSDMSEVQSMEISLNCDHEFFEKLTSELQSVEGLQREQRKILFNAIDILSHEISLIASPNSKKKYKSADQSHERTPELAERHLKWFDDQVRLAKCLPSSSKHRDRILYAKFLELNESLLKVASFQQMNKLAVTKIMKKFDKRTSLTAQPLFFQVIESDPLLLVDNASKAICFSLSS................................................................ 346
6 -6.690[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  6  674......................STLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQD-----------QKILSLKNKLKDL.......... 930
7 -6.600[OU] KOG2391 Vacuolar sorting protein/ubiquitin receptor VPS23  ali follow..  9  125.....LVSLPYLQNWIYPSSNLVDLASHLSAASQRRPPPQPSPSIGSGYSRPLPPRQTDDAAEVYKKNAINRIVEMVHGDIVLMRSAREVETEGLLSLQSDLKRREEEINNGFKEMVIEKETLEQQLQVIAMNTDVLGSWIRENQGKAKDLLVDLDVDDSFECIDSLSKQMLECTALVYSMDK-GSLPFDQYLRNVRLLSR-------EQFFHRATAEK................................................................................. 349
8 -6.590[S] COG5394 Uncharacterized protein conserved in bacteria  ali follow..  10  12.KYANR---RLYNTGTSTYVTLDDLAVMVKRFIVQDAKSGEDITHSVLTQIIFEQESKTGNTLLPISFLRQLISFYGDQMQMVVPSYLEHSMQAFTEQQAQMREQITKAFGDTPIGKNLKVPLQLVEEQVRRNTEMFHQAMQMFSPFMAAPPAKETRKAEAKDIDELKEQLRALQTKLDNL....................................................................................................................... 191
9 -6.540[R] KOG2627 Nuclear protein ES2  ali follow..  12  47.......KPKILTE--EKYIE--EMSKII-----------------------------------------------QRDFFERLRAQNDYLDAESRRDFVQMAEIRERYSLGRISGTGRSTSRRNNAMSPATFETPVSQAKCSNTPLPNSRATDTPFSTDGSEKSDAEGRDTTAKLSLDALQKYTSEDNQSFQEIIETAEAKLRQKYAVLYNHEKLSAE................................................................................. 211
10 -6.470[J] KOG0650 WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis  ali follow..  9  15......................EPTNEVVASSEASENEEEEEDLLQAVKDPGEDSTDDEGIDQEYHSDSSEELQFESDEEGNYLGRKQSSSAEEDEESSDEEDNEEEESTDGEEVEDEEKDSKSKQTDDKPSGSGAASKKALTAELPKRDSSKPEYQDSDTSDEEDIRNTVGNI------MHWYDEYKHIGYKKIIKQIDEFLRKIEDPDFWRTVKDPL--LTDEDI-ALIKRIVS................................................................ 235
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Wyrwicz LS, Godzik A, Kloczkowski A, Rychlewski L. Support-vector-machine classification of linear functional motifs in proteins. J Mol Model 2006 Aug;12(4):453-61. Epub 2005 Dec 10.