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Query: [L] COG5421 Transposase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAEKDSSRRVESSLKRTRFLGHLGLIVGVFRELEVDNLIDEKLPKERDHTVPHSVCILAMLLNGLGFVGQRLYLFPDFFKNISTERLFGDGITREDLNQYVIGETLDRIVKYGPTKLFTEIALHIMTHLPIPVHCLHADTTSVSVYGDYDDEETESIDITFGIPKNGRWDLKQFVLSLIVNQHGIPLFMNTHSGNSSDKNTILEAIQSLKSVLRPESEVYYVADSSFYTDNNIKNMGKSFWISRVPATITEAKELLTANLNLKTLKSDERYSFYQTFVEYGGVKQKWVLLLSHKMKEKKEQTLRTKLEKEVEKAEKSFKKLKGEDFFCEEDALKAAEKWIQDFPSVSFEKVDVKSIKKRELGKRGRPSKDEQLKTYCRINGIIKVNDAFVLNEMDKMGLFILASNDINLSPEDMLKYYKGQDNVEKGFRFLKSNTFSISKVYLKNKKRIEAMTMIMVLCLMIYSIAEWKLRTKLEEENETIPDQKGKPTKRPTMRWIFFNFQGITELISQNKGQMKSEILNMEEIHWKILGLMGEKYENIYLLast
1 -172.000[L] COG5421 Transposase  ali  100  1MAEKDSSRRVESSLKRTRFLGHLGLIVGVFRELEVDNLIDEKLPKERDHTVPHSVCILAMLLNGLGFVGQRLYLFPDFFKNISTERLFGDGITREDLNQYVIGETLDRIVKYGPTKLFTEIALHIMTHLPIPVHCLHADTTSVSVYGDYDDEETESIDITFGIPKNGRWDLKQFVLSLIVNQHGIPLFMNTHSGNSSDKNTILEAIQSLKSVLRPESEVYYVADSSFYTDNNIKNMGKSFWISRVPATITEAKELLTANLNLKTLKSDERYSFYQTFVEYGGVKQKWVLLLSHKMKEKKEQTLRTKLEKEVEKAEKSFKKLKGEDFFCEEDALKAAEKWIQDFPSVSFEKVDVKSIKKRELGKRGRPSKDEQLKTYCRINGIIKVNDAFVLNEMDKMGLFILASNDINLSPEDMLKYYKGQDNVEKGFRFLKSNTFSISKVYLKNKKRIEAMTMIMVLCLMIYSIAEWKLRTKLEEENETIPDQKGKPTKRPTMRWIFFNFQGITELISQNKGQMKSEILNMEEIHWKILGLMGEKYENIYL 542
2 -27.700[L] COG3385 FOG: Transposase and inactivated derivatives  ali follow..  12  7........................IFAQLLKAIDFQAIVDRHAGDAYDKCFTSWDHLVALIYAQLSATTSLRGLEASFNANSQHHYHLGSGRLMRSTLSDANRRRPVAVFAETFALLAGQLDRQTRREGTKMLRLI--DSTPIPLGKLYD--------------AKSNGRIRGMKLHVVYDKADCPGILDITDANVNDAQIGRTITIE--------KGATYVFDKGYCHYGWWTAIAEAGASFVTRPKTNMGLALVA----------------------------------------------ERPVEQPQGDGFLVLEDSQVSLASKGDSKLPIGLRR--------------------------------------------------VIVKRQDGDTITLLTNDLERSAVEIGQLYKDRWQIELLFRWIKQHL-KIRKFLGNNDNAIRLQIFAAMIAYALLRIAARLARVP..................................................................... 339
3 -12.300[L] COG5433 Transposase  ali follow..  9  1.............................MELKKLMEHISIIPDYRQAWKVEHKSDILLLTICAVISGAEGWEDIEDFGETHLDFLRQYGDFENAIPVHDTIARVVSCISPAKFHECFINWMRDCHSSDDKDVIAI-------------------DGKTLRHSYDKSRRRGAIHVISAFSTMHSLVIGQIKTDEKSNEITAPPELLNILD------KGKIITTDAMGCQKDIAEKIQKQGGDYLFAV-------------------------------------------------KGNQGRLNKAFEEKFPLKELNNPEHDSYAISEKSHGREEIRLHIVCEVPDELIDFTFEWKGLKKL----------------CVAVSFRSIIAEQKKEPKMTVRYYI--SSADLTAGKFATAIRNHWHVENKLHWRLDVVMNEDDCKIRRGNAAELFSGIRHIAINI-------LTNDKVFKAGLRRKMRKAAMDRNYLASVL............................................ 372
4 -11.400[L] COG3666 Transposase and inactivated derivatives  ali follow..  11  32......................ARVVNDMVESLDD-QLFDEVYKGGGRPAYHPKMMTKILLYGYTQKWFSCRAIAKALTEHLPMMWLAARQT-----DFRTINRFRSERLKPLMDTLFSALTHLLIKEGYVDGSSYFLDGTKIEANANYSKTDPDATFMRMKDDHMKNGQLKAGYNWQIGTQDQFILFYTVHP-NPTDTRCLLPHVEALKESGLPLPKTL-IADAGYGSESNYVAMADELFETLIPSHTFRQEQ----------KRSFAKKRFHPYNWRCDETDDVYWCPNQRKVSFKRYTKRTDPYGYARDFKVYECESCEGCPFKPECTKARGNRQVHYNPVYEELKAKQ-----------------------------------------------------HQKLKSEEGRTLYQKRKDVESVFGHVKQN-LGFRRLHLRGKESVHIELGLVALAHNLRKRATVDRRSKEPK.................................................................. 537
5 -10.100[L] COG5659 FOG: Transposase  ali follow..  9  17..................................FAEYMNYLAEGLGHA--DRRAGLESYCTGLMLPLSRK--------------SVEPMAARVDPLHASARHQSLHHFVSKSDTALLSRVRDWVQPLLEAPSGRYWIDDTGFPKKGKHS-----------GVARQGKQDNCQVAVSLATEQGSLPIAYQLYKAGVPDDIVFATKPEIALAQVREAIA-VVLADAAYGDETGFENLTELGLLYAVGIR----------------------------------STTTVWPPGVSPLPAKPASGPGRPPKLLRRAPGHEPVSVKTLAMALPSSAYQVVTWREGINTALSSRFAAVRVRPAHRDYWRSTLRDEEWLLVEW-------------PGGEAEPTKYFLSTAPADALIEQLVFVTKMRWRIERDYQDLKQE-LGLGHYEGRGWRGFHHHATLSIAAYGFLMAERLAADKP..................................................................... 411
6 -9.750[L] COG3039 Transposase and inactivated derivatives, IS5 family  ali follow..  8  41..................................VTSDLRRQGVTEGRQGLPSEAVLRCALLKQYRQLSYE-ELAFHLEDSASFRAFARLPWGWS--KKSVLHKTISAIRADTWEAVNKMLLASARQERLESGRVVRVDSTVTAALIHEPSDSSRARVIEYTRGRPKRPHADIIVKGLTTGRSGLILDLVIEAGNPADSERLLPLLERHIAFYGEAPRQA-AADGGYASRENLRQAKAWGVRDMAFHKKSG----------------------------------------LRIEDMVRSRWVYRKLRNFRAG--------------------------------------------------------------------------------------------------------------IEAGISCLKRT-YGLARCTWRGLDHFKTYVWSSVVAYNLALFAR........................................................................... 440
7 -8.890[L] COG5558 Transposase  ali follow..  12  29.EEKEKYPYTEWERKREVVKERLRKLPEYVREA--ISVITVQKRVGRPKKVDLEKRVMLFLFARLMDKSNR-------------DIEELLELFEPLFGIKVSYKTIERLYSDEEVRMALHNLFILLLREEGVSGDFSGDGTGYSLTITKHYRSNP---------KRKGKDFRYVFRIIDIDTGMY-VGFGYSDRSEKDAFEKALGMLKSMGV-------SISLDKYYSSRKTLRLFDAETAVYVIP--------------------------------------------------KRNLARIGFDWLRVIERIVE---------------------------------------------------------------------------------------------APYRFLKRYFKRNLSEAGFSADKRRF---WLIRQRREDRREMALFAVGLWHNVFAVRVVR......................................................................... 322
8 -6.260[R] KOG4679 Uncharacterized protein PSP1 (suppressor of DNA polymerase alpha mutations in yeast)  ali follow..  12  546....................................................................................................................................................................KNGKLE-----LLSTPQATNLLL-----RGD-----------------------LVIIGDRG----RDLVLVVEPSVDLNLALFINFLKKKIHFDSLITSESQHYRNDEFIQMLIDSKNGQKKKLNPKLYDVVELTELIIPSKQVLRFATPWEVTTNLHNKFEDELKALHIAQSKLQALNDNSKSQNTNDSSSNNFTNAA-------------------TYSKPKLNIK--------ILNAEFQFDRKELTFYYVCEERND--FRDL------IKELFKYYKTRI--------------------LCAIPNNLSIDSKYYDKQQKELKLYQNIVKNYNAEDLMNVNEFSQNRGNNRVNFAPPLNEIELDNFQIAVY.. 832
9 -6.110[RT] KOG0748 Predicted membrane proteins, contain hemolysin III domain  ali follow..  7  3...................................................................................................................................................................................................................................................................................................................................................................................DEAEIKEHLKPQASSETMDKKHNVKGKRLWQKVKYQLVEFHSLPAYLRDNEYIIGHYRSEWPIKQILLSIFTIHNENVWTHLFFLFLALTIYTATK........................................................................... 102
10 -5.990[L] COG3293 Transposase and inactivated derivatives  ali follow..  13  68................................................................................................................RKASVWDRLMDAITAVHDGDIQM---IDSTSVRAHQQAATAKKGGQITVSVTRGGLTTKIH----VVVDAQGLPIRLGLTAGQAHDSQIADQLLNHLSPRTI------VLADKAYDADRIRSLIEGQGATPNIPPKSNRRWKPCFSK------------------------------------------------------------------------------------------------------------------------------------------------------------RLYRERNLIERFFSKLKH---RIATRYDKLAANFLAMVQLASMRLWLRAYES........................................................................... 252
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 0 6 0   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Schwarzenbacher R, Godzik A, Jaroszewski L. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. Epub 2007 Dec 5.