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Query: [T] COG5432 RING-finger-containing E3 ubiquitin ligase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDHQITTASDFTTTSIPSLYQLDTLLRCHICKDFLKVPVLTPCGHTFCSLCIRTHLNNQPNCPLCLFEFRESLLRSEFLVSEIIQSYTSLRSSLLDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVNAADDDLQIVATSERKLAKRSMTDILPLSSKPSKRNFAMFRSERIKKKSKPNEQMAQCPICQQFYPLKALEKTHLDECLTLQSLGKKPKISTTFPTESNPHNKSSSRFKVRTPEVDKSSCGETSHVDKYLNSMMSAEHQRLPKINFTSMTQSQIKQKLSSLGLSTNGTRQNMIKRYNHYEMLWNSNFCDSLEPVDEAELKRQLLSWDVSHNKTPQNSSNKGGISKLMIMKSNGKSSSYRKLLENFKNDKFNRKGWMVMFRKDFARLIREAKMKIKTGSSDSSGSVGHSNDGDGVEKVQSDQGTEDQQMEKDQDTVINEDRVAGERNLPNEDSTDADLSRELMDLNEYSKDPPGNNLast
1 -137.000[T] COG5432 RING-finger-containing E3 ubiquitin ligase  ali  100  1MDHQITTASDFTTTSIPSLYQLDTLLRCHICKDFLKVPVLTPCGHTFCSLCIRTHLNNQPNCPLCLFEFRESLLRSEFLVSEIIQSYTSLRSSLLDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVNAADDDLQIVATSERKLAKRSMTDILPLSSKPSKRNFAMFRSERIKKKSKPNEQMAQCPICQQFYPLKALEKTHLDECLTLQSLGKKPKISTTFPTESNPHNKSSSRFKVRTPEVDKSSCGETSHVDKYLNSMMSAEHQRLPKINFTSMTQSQIKQKLSSLGLSTNGTRQNMIKRYNHYEMLWNSNFCDSLEPVDEAELKRQLLSWDVSHNKTPQNSSNKGGISKLMIMKSNGKSSSYRKLLENFKNDKFNRKGWMVMFRKDFARLIREAKMKIKTGSSDSSGSVGHSNDGDGVEKVQSDQGTEDQQMEKDQDTVINEDRVAGERNLPNEDSTDADLSRELMDLNEYSKDPPGNN 487
2 -137.000[L] KOG0287 Postreplication repair protein RAD18  ali follow..  100  1MDHQITTASDFTTTSIPSLYQLDTLLRCHICKDFLKVPVLTPCGHTFCSLCIRTHLNNQPNCPLCLFEFRESLLRSEFLVSEIIQSYTSLRSSLLDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVNAADDDLQIVATSERKLAKRSMTDILPLSSKPSKRNFAMFRSERIKKKSKPNEQMAQCPICQQFYPLKALEKTHLDECLTLQSLGKKPKISTTFPTESNPHNKSSSRFKVRTPEVDKSSCGETSHVDKYLNSMMSAEHQRLPKINFTSMTQSQIKQKLSSLGLSTNGTRQNMIKRYNHYEMLWNSNFCDSLEPVDEAELKRQLLSWDVSHNKTPQNSSNKGGISKLMIMKSNGKSSSYRKLLENFKNDKFNRKGWMVMFRKDFARLIREAKMKIKTGSSDSSGSVGHSNDGDGVEKVQSDQGTEDQQMEKDQDTVINEDRVAGERNLPNEDSTDADLSRELMDLNEYSKDPPGNN 487
3 -36.000[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  20  246...................KKEDIPFVCLICKKDYRSPIATTCGHHFCEQCAITRYRKTPTCIQCGADT-KGLFSVDKNFDRLLKNRKSKNDEAVKQKVGGFESNNSATTEVSERKDREAS.............................................................................................................................................................................................................................................................................................................................................................................. 346
4 -34.100[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  9  1....MNASTSSPSQQLQQAINSTIDKECAVCYSEMILPTTIPCGHKFCFICLKGVSSNNGDCPICRGPIDSQIFKKPLQAVDLKMDIPGTPSAAAPDPVVKQEVDDEDVKPDVKKLQEELKKQQAAAAAQKMFWLYRGRHQGWWRFDPRIEKEIEEAFTHQMP.................................................................................................................................................................................................................................................................................................................................... 161
5 -32.900[R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  11  276.............WRKGHFKDLPDDLKCPLTGGLLRQPVKTSCNIDFSKEALENALESDFVCPNCETRILLDSLVPDQDKEKEVETFLKKQEELHGSSKDGNQPETKKMKLMDPTGTAGLNNNTSLPTSVNNGGTPVPPVPLPFGIPPFPMFPMPFMPPTATITNPHQADASPKK........................................................................................................................................................................................................................................................................................................................ 441
6 -32.700[O] KOG1813 Predicted E3 ubiquitin ligase  ali follow..  21  272......................ALPFACFICREPFVDPVVTKCKHYFCEHCALKHHTKNKKCFVCNQPT-MGIFNAAHEIKKRMAEERSKAEQ.......................................................................................................................................................................................................................................................................................................................................................................................................... 341
7 -31.100[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  29  111......................GGFFDCNICLEKAEDPILTCCGHLFCWGCFYQLPLIYLECPVCDGEVTDAEVIP........................................................................................................................................................................................................................................................................................................................................................................................................................... 167
8 -30.600[DKL] COG5220 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3  ali follow..  12  1...............MDDEGARKVDEKCPLCQANMKLLINPECYHKMCESCVDRIFTTGPATPGCNKILRKAKFREQTFEDAQIEREVDVRKRISRIFNK--GQQEFDSLQAYNDYLEEVEILTFNLIYKI------DVEETEEKVKQYEKQNRDSIAANSARAAAEARILAQNEILLKRQKQEAREAAIREHQKEKERREQVEQQIIFDLATSGKDPNKIIQLSDSLKKQQENIASSVSNISRSS................................................................................................................................................................................................................................................. 232
9 -30.300[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  30  836................EEVKNCKNILKCGVCFDRPKEVVIVKCYHLFCQQCIQRSLEIRHKCPGCGTAFGQNDVRL........................................................................................................................................................................................................................................................................................................................................................................................................................... 896
10 -30.100[S] KOG2660 Locus-specific chromosome binding proteins  ali follow..  9  6.................KKETMRACLSCSICDNILRDA------TTISEKCIYEKITEDETCPVCNIDLGSTKLRPDHNLQDLRAKIFALKRRKVKAPGIVSLPGKRKERSISSLVVSTPMVSAQAGTTRRRTKAPTRKELRNGSLAERTVKKEESSGDELLESTSSPDTLNKFTQNKRQSKKSCKESISNKENKDGDEPWDSKMDWKPLNFLVEVANGTKPLKSSASQGSGSKSEHANVSRNQFQGSKTKTKNKKRKCKREDDKSNNGDPTTSETVTPKRMRTTQRKRFSLVASNDQEGGTSLPQIPANFLRIRDGNT-------TVSFIQKYL-----MRKLDLESENEIEIKCMGEAVIPTLTLYNLVDLWLQKSSNHQRFAALVGSSAKDFTMVLVYARK................................................................................... 408
11 -28.400[O] KOG3800 Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor  ali follow..  9  2..........................ECKKCKSEYTNKMINECGHPLCKNCVDNIFALNSNCHVCNRVLRKNNFREQIYEDPLIDKETFLRRKLRKIYNLKQDDENLREFGDYQERKFFEPLKFPVKIKISNFRRFKNFKNFFYEFSIRYSNSPSFSWSNPEFSAQNSKIAPSNSKF-------------------------------------------------------------------------------------------QFFRFETVVYNLVFETNVNETNAEIQAFEEKHKEQIDRNKRR---------------DDQKWIEDQLREERAMKARMTDHMEMDAKEQ-----EAASAVTDTRKIMDELRDSNVAAEVILDRERKKQIEKELEEKEEQEKRKRRNKEMLQTRKRAAENMSFNTVIRVAGRAYVHQVGHENSEEIEKMQLFHSKFQIFKSIFRFSPLELVINGPPMPNVS 360
12 -28.400[O] KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein  ali follow..  28  281......................EASRKCILCLMNMSDPSCAPCGHLFCWSCLMSWCKERPECPLCRQHCQPQEI............................................................................................................................................................................................................................................................................................................................................................................................................................. 332
13 -28.100[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  35  261......................EELYKCPICMDSVREPVSTKCGHVFCRECIETAIRATHKCPICNKKLTARQFFR........................................................................................................................................................................................................................................................................................................................................................................................................................... 316
14 -26.100[O] COG5574 RING-finger-containing E3 ubiquitin ligase  ali follow..  21  345............SSKLFSIIPQLRDFECAICSNVAYKPVRLGCSHVFCLHCLIILQKQKVFCPLCRAKEVADSRNIDHALMNFMKTY................................................................................................................................................................................................................................................................................................................................................................................................................ 422
15 -25.700[O] KOG4265 Predicted E3 ubiquitin ligase  ali follow..  22  273......................DNSNECVVCLSDLRDTLILPCRH-LCTSCADTLRYQANNCPICRLF-----------PGPPADPGGAEEAR.......................................................................................................................................................................................................................................................................................................................................................................................................... 333
16 -25.600[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  21  275............RRARSRPHTLSQDQLCVVCSTNPKEIILLPCGHCLCEDCAQK----SVTCPVCRGS-----------IVSKAAAFIA.............................................................................................................................................................................................................................................................................................................................................................................................................. 338
17 -25.000[O] KOG0826 Predicted E3 ubiquitin ligase involved in peroxisome organization  ali follow..  20  239......................PQRGECPVCLLSIQTPACSVSGYVFCWKCIVSHMKEHGTCPVTHYPIS---------LDDLVRIYET.............................................................................................................................................................................................................................................................................................................................................................................................................. 297
18 -23.700[O] KOG4159 Predicted E3 ubiquitin ligase  ali follow..  37  1...............................MRLFFEPVTTPCGHSFCKNCLERCLDHAPYCPLCKESLKERRYCVTQLLEELIVKY................................................................................................................................................................................................................................................................................................................................................................................................................ 60
19 -23.400[R] KOG3002 Zn finger protein  ali follow..  24  31.NSKPTKSGSGSIGKFHSSNGVYELLECPVCTNLMYPPI-HQCGHTLCSSCKLR----QNTCPTCRYELGNI---RCLALEKVAESLE............................................................................................................................................................................................................................................................................................................................................................................................................... 112
20 -23.400[O] KOG0800 FOG: Predicted E3 ubiquitin ligase  ali follow..  10  76LSKELREM--LPIVVFKESFTVMD-SQCSVCLGDYQP-QIPVCKHTFHMDCIDLWLTSHTTCPLCRLALIPSR---------------------------SRQSQDDPVPSLVSPDEEVSSQPESEPVNHRVVSTQPESEPVNHSGVSSQPESQPVVNHRGVSSQPESQPVNHINDGHEQQCDQDVEGFKEMEEDERNNIGTSSACCSCRTVHYCCVSRDNQIMYAYNNAGDHRNNESLAALCLEKTPPFHKWYFETRGKKTFG---------------LMKDDFVYFAIVDDVFKKSSVLDFLEKLRDELKEANKKNFSNVQDQ-----IVRRLIASLEFDHTCLPLSSPSIDGAEQSYASNSKAP------------------------------LLGRSNKQDKKKGRDHAHSLRGIEIEEHRKSNDRGNVTECSNASSESATYVPRRGRSGGSQSIER......................... 472
21 -23.000[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  27  642................PAVEKLATDELCKICMDAPIECVFLECGH--CTSCGKV-----NECPICRQY-----------IVRVVRFFRA.............................................................................................................................................................................................................................................................................................................................................................................................................. 700
22 -22.900[O] COG5540 RING-finger-containing ubiquitin ligase  ali follow..  24  313...................RRATFGVECVICLESFTK--ALPCKHEFHRPCIAKWIDYRHACPTCNTEVPPPK.............................................................................................................................................................................................................................................................................................................................................................................................................................. 370
23 -22.000[O] KOG0802 E3 ubiquitin ligase  ali follow..  10  342LHAALPDATS------EELRAYDDE--CAICREPMAKAKRLHCNHLFHLGCLRSWLDQGYSCPTCRKPLFVGR------------------------------------TENEVNPRTVEVSSDEQLARQLERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGLGRVQMMMRHLASVGESYAQTALDDAAWSLWPMNPSQASTSSTTVPPGNGGRTGGLHLRTVSNTTNESLTNILAMAETVREVMPHVPDEIIFQVNFKCI...................................................................................................................................................................................................... 590
24 -21.600[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  8  100......................KVTLRDCLVLSVWKFGANTKSGILDSIVFPVDTCMDTSGFSSDEVEGSLRDVRK--YASRVAAVDDEAHKRILFLEAKLRSIEQKTASWSNKEVQWKITEAELRLEVTKLKKKIANMESTTKGSQSQSNVASQEK.......................................................................................................................................................................................................................................................................................................................................... 240
25 -21.500[O] KOG0801 Predicted E3 ubiquitin ligase  ali follow..  21  179......................KDAGECVICLEELLDTIALPCLCIYHKSCIDSWFEVNRSCPEHPAD................................................................................................................................................................................................................................................................................................................................................................................................................................... 227
26 -21.400[O] KOG2164 Predicted E3 ubiquitin ligase  ali follow..  8  185.QSQKLDPDKWEDVWQVLCSSDFQLAACPFCLE---AARMSRCGHVYCFSCLLRFVETPTSCPICWDSIRLRDVHPIRWVED----------------KEFQKLEEGKSVCLRLYQRNNGSILAFPRSCRSFALDGSFHSDEIPNFTMSGAAYARIIIGSHDYMVQQHLLEIEQLQQIAAEDISLYGSADTYYERITQILLDRISSLSESVNEQNIKSLQTDIDNLCLQSNSLKQLSEVDDLNDVSGSEIADA-LKSAFGSYENFPDELVPRVERISSGHLVNSELRQRFKYMALPEGCE-----------VAFIECDWSKIIPKEVLLTFKSEISKRRKQRKAQEMREERYR--------QRAERDTEEQIYSELNMQRPVPKTVVHEDPAEAFPTLGSHHQFESTDEVNTDESTLSTAKTVWGTRALANIQNDTDDQDDLDGWKVDWDKVAQLSAPSKNSKNKKKKK.................. 662
27 -21.400[S] KOG4367 Predicted Zn-finger protein  ali follow..  9  1..................MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPECPQCHRSLI-RGFPKNRVLEGVIDRYQQSKAAALK----QLCEKAPKEATVMCEQCDVFYCDPCRLRCH---------PPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFL-----------------------------------------------VQLRNMVQQIQENSVEFEACLVAQCDALIDALNRR---------KAQLLARVNKEHEHKLKV-----------------RDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMT................................................................ 410
28 -21.200[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali follow..  12  329........DTLVTVTVEQLQNSAND-ICIICMDELKKPKRLPCGHILHLSCLKNWMERSQTCPICRLPVFDEK-----------------GNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLTIENHEVNSLHGDGGEQIAKKIVIPDKF................................................................................................................................................................................................................................................................. 547
29 -21.100[O] KOG2177 Predicted E3 ubiquitin ligase  ali follow..  15  2..............NSGILQVFQRELTCPICMNYFLDPVTIDCGHSFCRPCFYLNWQDMAQCSKCKETTWQRNLNTDICLKNMASIARKASLRQFLSSEEQICGMHRETKKMFCEVDKSLLCLLYSNSQEHRNHRHCPIEWAAEERRSLWEKACENLRNLNMETTR................................................................................................................................................................................................................................................................................................................................. 156
30 -21.100[L] COG5627 DNA repair protein MMS21  ali follow..  19  182.ADEV------------MVYSATFDNRCPLTLQPIVHPISTACNHFYEKDAILSLLNPTCVCPVCEARLQRSLLKEDEILERRLRRAQEISNL.......................................................................................................................................................................................................................................................................................................................................................................................................... 264
31 -20.500[O] KOG0828 Predicted E3 ubiquitin ligase  ali follow..  26  691...................GTAEHTVDCAICMSDVPIYMVTPCNHVFHTSCLENWMNYKLQCPVCRSPL.................................................................................................................................................................................................................................................................................................................................................................................................................................. 755
32 -20.000[DR] KOG4739 Uncharacterized protein involved in synaptonemal complex formation  ali follow..  20  1.....................MD--IQCNHCGIKPNQTYLTACGHVFCQNCTKA--AFNSQCYLCKKPLKVDEINKNL--PDLMELFKDPRQLASDLVNE................................................................................................................................................................................................................................................................................................................................................................................................... 77
33 -19.800[O] KOG4692 Predicted E3 ubiquitin ligase  ali follow..  24  446..RRLIDSLRVKQTLLSDITLPSEDSLCPICCAKPITAVFTPCKHQSCSDCIMQHMMNSKVCFYCKTTIQT................................................................................................................................................................................................................................................................................................................................................................................................................................ 514
34 -19.800[O] KOG3970 Predicted E3 ubiquitin ligase  ali follow..  12  38............QSYLTWLTDQDYDPNCSLCKTTLADTIRLNCLHLLHWKCFDEWAANFPRCPCCSQEVFPPINEVSPLIEKLREQLKQSNWARAALGLPTLPELNRPVPSPAPPQLKNAPVMHKEVPVHNNRSSTPATHLEMEDTASYSVSNNDVTFARKKNYGAESSSDTRPLLQLRDADNEENK............................................................................................................................................................................................................................................................................................................ 222
35 -19.100[O] KOG0827 Predicted E3 ubiquitin ligase  ali follow..  28  3........................NLNCVICAELFDEVFATVCGHMFHHNCLNQWLDRSKTCPQCRNKCTTRNI............................................................................................................................................................................................................................................................................................................................................................................................................................. 55
36 -18.700[O] KOG1100 Predicted E3 ubiquitin ligase  ali follow..  22  279...................MCRVGMSMCRSCGKGEASVLLLPCRH-LCSVC-----SSLNTCPICKSP-----------KTASLHVNLSS............................................................................................................................................................................................................................................................................................................................................................................................................. 335
37 -18.600[O] KOG4185 Predicted E3 ubiquitin ligase  ali follow..  13  2.......................SFIDCEICDEEFSTPRILRCGHTTCHGCAEKLLRNSTLCPFCREATNVKDLQKNFALLQAVEHTKTKTEEKDSIDAPPKCASHQYNLEPTCRSSDKLMCRTCEEFGAHAGHKKGLLQSEAAKLRQFLSGKLSRSEELASQIEEKIGRAQLTNIDDGEVFQEKKDSIVSYYTTLRMTLDALENEALEKLQNIAEANFSRNEILVAELSESLEKQKSKSAELKLFMEMSNADLLAVNSVMDASNETEIWNDVSPGITNV............................................................................................................................................................................................................... 277
38 -18.200[T] KOG0297 TNF receptor-associated factor  ali follow..  9  1MAAASVTPPGSLELLQPGGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQCAACVHEGIYEEGISILESSSAFPTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTY--------DGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLDQNNREHVIDAFRPDVTSSSFQRPVNDMN........................................................... 464
39 -17.900[R] KOG2979 Protein involved in DNA repair  ali follow..  24  246........................NMTCPLSVTELADPVSMDCRHVYEKSVILHYIVNNPNCPVCRGKLQNSKVICDAMLKFEIEEMRSLNKQ.......................................................................................................................................................................................................................................................................................................................................................................................................... 322
40 -17.500[O] KOG4628 Predicted E3 ubiquitin ligase  ali follow..  14  216........KKLPVLRYTKNNANNKYDTCVICLEDFIE--VLPCSHPYHTHCIDPWLENRRVCPICKR--------------KVFTKGEARASRSRQPSLDNVTDTDDDTTPLLQQQQSNGRQVGQVSSASSAGGAAGSSSSVAAAAVAGTTRHGTFRRGHAGRNPFEESQSSDDENA...................................................................................................................................................................................................................................................................................................................... 374
41 -16.300[O] KOG2879 Predicted E3 ubiquitin ligase  ali follow..  21  312......................EDTVTCPICQVDPAIPLKELTCRRYCYYCIRTRCASAARCLRCNEPVVAIQ.............................................................................................................................................................................................................................................................................................................................................................................................................................. 381
42 -15.900[S] KOG4638 Uncharacterized conserved protein  ali follow..  13  356..............SYATTEQATCV-ARRRCTPQFFAKIAFQSGEVFLHIAIIFVYE.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 406
43 -15.800[O] KOG1039 Predicted E3 ubiquitin ligase  ali follow..  20  223............EMEKAFAFQASQDKVCSICMEVILE-ILSNCNHTYCLSCIRQWRCAKQSCPECRVISE---VEDQNKKNELIEAFKQGMGKK......................................................................................................................................................................................................................................................................................................................................................................................................... 325
44 -15.700[OD] COG5194 Component of SCF ubiquitin ligase and anaphase-promoting complex  ali follow..  24  54..........................NCAICRNHIMEPAWGVCNHAFHLHCINKWIKTRDACPLDNQPWQLARCGR........................................................................................................................................................................................................................................................................................................................................................................................................................... 121
45 -15.000[O] KOG1814 Predicted E3 ubiquitin ligase  ali follow..  12  169......................IRKFQCNVCFD--DCFQLTRCGHVSCQSCLRDYYTMC-KCIDCGKDAPVLTLKELESIVQLTNRYKELEEKRRYENDSNIIFCPRSFCQGPSKRDPGQKLAICQKCDCKLEGDSKKLVEMYLNYQENEPEKALELEKRYGKRIIDRLVEQVKNDEEAEKWVLLNGQRCPTCDRVVERIDGCCHMNCLC..................................................................................................................................................................................................................................................................................... 388
46 -15.000[O] KOG4172 Predicted E3 ubiquitin ligase  ali follow..  33  4...................QEVNEGDECTICMDAPVNSVLYTCGHCMCFECGRRLLTTKGTCPICRAP-----------VQDVIKTYKS.............................................................................................................................................................................................................................................................................................................................................................................................................. 63
47 -14.800[DR] KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins  ali follow..  24  545.MKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVCQECAPS-----RKCPICRGI-----------IKGTVRTFLS.............................................................................................................................................................................................................................................................................................................................................................................................................. 618
48 -14.800[O] KOG3268 Predicted E3 ubiquitin ligase  ali follow..  20  280VLQNLKDVLEIDFPARAILEKSDFTMDCGICYAYQLDPDQVQCGQPFHQICLYEWLRGLLTCPYCSKPIT................................................................................................................................................................................................................................................................................................................................................................................................................................. 367
49 -14.700[DO] KOG1493 Anaphase-promoting complex (APC), subunit 11  ali follow..  31  71..........................TCGICRMEFESAVLGICRHAFHRHCIDKWIAAPTNCPLCRQDWTIVE.............................................................................................................................................................................................................................................................................................................................................................................................................................. 135
50 -14.700[O] KOG1734 Predicted RING-containing E3 ubiquitin ligase  ali follow..  18  309......................VHDADAVVTTKMVEKLYKLSCGHVFHEFCIRGWVGKLQTCPYCKERVDLQRMFKN.......................................................................................................................................................................................................................................................................................................................................................................................................................... 369
51 -14.400[A] KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain  ali follow..  11  1...................................................................................................................................................................................................................................................................................MDVRRLKVNELREELQRRGLDTRGLKTELAER-----------LQAALEAEEPDDERELDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPGGYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEE 201
52 -14.300[S] KOG4445 Uncharacterized conserved protein, contains RWD domain  ali follow..  21  36VTLQVHPTPGYPEEDDARLEAIRSACNCVVCLYGFAD-TRTECFHYLHSYCLARHLNAQALCPVCREHIGDET.............................................................................................................................................................................................................................................................................................................................................................................................................................. 178
53 -14.000[O] KOG2930 SCF ubiquitin ligase, Rbx1 component  ali follow..  20  1MEVDEDGYEVPSSSSKGDKKRFEVVDNCAICRNHIMDLAWGVCNHAFHFHCISRWLKTRQVCPLDNREWDFQKY............................................................................................................................................................................................................................................................................................................................................................................................................................. 106
54 -13.600[O] KOG0006 E3 ubiquitin-protein ligase (Parkin protein)  ali follow..  12  195............PVALHLIATNSRNITCITCTDVRSPVLVCNSRHVICLDCFHLYCVTR-PCVAPNSLIKELHHFR----EEQYNRYQQY............................................................................................................................................................................................................................................................................................................................................................................................................. 290
55 -13.600[R] KOG1313 DHHC-type Zn-finger proteins  ali follow..  19  96....FKCAGKPTNILYGTHPGVGNGALCNYC-SKPKSPRTHHC--RTCGMCVLDM---DHHCP-C...................................................................................................................................................................................................................................................................................................................................................................................................................................... 158
56 -13.300[O] KOG3579 Predicted E3 ubiquitin ligase  ali follow..  19  457.GLEPVHPASLPDSSLATSAPL----CCTLCHERLEDTHFVQCSHKFCFPCSRQSIKQQGACPSC--AFMQGEIAT--ILAGDVKV-KKERDS.......................................................................................................................................................................................................................................................................................................................................................................................................... 560
57 -13.300[O] KOG2231 Predicted E3 ubiquitin ligase  ali follow..  24  43......................NDDNACVVCFKNVEIFSIGDCDHPVCYECTRRVLCQQNECPICRHVLSK................................................................................................................................................................................................................................................................................................................................................................................................................................ 93
58 -13.200[O] KOG0314 Predicted E3 ubiquitin ligase  ali follow..  10  191............TSTTRSVGEFPPELKCPLCKEVMRDAALASCLKSYCDKCIRDHI--AKSMCVCATHVLADDLLPNKTLRDTINRILESGNSSAENAGSMCQVQDMESVRCPPPKALSPTTSAASGGEKKPAPSNNNETSTLKPSIEIAEITSAWASAEIVKVEKPVDASANIQGSSNGKEAAVSQLNTQPPKEEMPQQVASGEQGKRKKKKPRMSGTDLAGPDYMMPNIPPPYRDLAEMGNRMNLQHPIMGREEFEAKKTEMKRKRENEIRRSEGGNVVRDSEKSRIMNNSAVTSSPVKPKSRQGPPPPISSDYDRRRRSDRSSPERQSSRRFTSPPRSSSRKSERDRHHDLDSEHDRRRDRPRETDRKHRKRSEKSSSDPTVEIDDNNKSNVFTRISFPEESSGKQRKTSKSSPAPPESSVAPVSSGRRHHSRREREMVEYDSSDDEDRHFKRKPSRYKRSPSVAPSDAGDEHFRHSKRSKGER 741
59 -12.900[R] KOG1312 DHHC-type Zn-finger proteins  ali follow..  13  105....MVSRAEDSKDHKSGSTEEYPYDYCSTC-RIVKPARSKHC--SICNRCVLVA---DHHCI-C...................................................................................................................................................................................................................................................................................................................................................................................................................................... 170
60 -12.800[O] COG5113 Ubiquitin fusion degradation protein 2  ali follow..  8  860FANKAEEQRKADEEEDLEYGDVPDEFLDPLMYTIMKDPVILPASKMNIRSTIKAHLLSDSTDPFNRMPLKLEDVTPNEELRQKILCFKKQKKEEAKHKASE.................................................................................................................................................................................................................................................................................................................................................................................................. 961
61 -12.700[R] KOG2789 Putative Zn-finger protein  ali follow..  28  146......................ANAMECPICFLYYPSNFNYTCAQPICSECIRR-ISEPAKCPYCMTE................................................................................................................................................................................................................................................................................................................................................................................................................................... 215
62 -12.600[K] KOG2068 MOT2 transcription factor  ali follow..  12  4......................YGEKTCPLCAEEMDLT--CKCGYQICVWCWHHIMDMAEKCPACRTPYDKEKIVGMTVDQERLASEGNMDRKKIQKSKPKSSDGRK............................................................................................................................................................................................................................................................................................................................................................................................ 98
63 -12.500[R] KOG1314 DHHC-type Zn-finger protein  ali follow..  9  77....FVGPGFVPLGWKPEISQDTMYLQCKVC-QAYKAPRSHHC--RKCNRCVMKM---DHHCP-C---------YQNHASFTLFLLLAPLGCIHAAFIFVMTMYTQLYHRLSFGWNTVKIDMSAARRDPLPIVPFGLAAFATTLFALGLALGTTIAVGMLFFIQMKIILRNKTSIESWIEEKAKDRIQYYQLDEVFVFPYDMGSRWRNFKQVFTWSGVPEGDGLEWPVREGCHQYSLTIEQLKQKADKRVRSVRYKVIEDYSGACCPLNKGIKTFFTSPCTEEPRIQ---------QKGEFILATRGLRYW--LYGDKILDDSFPRKVEKCPCDAETDQAPEGEKKNR........................................................................................................................................... 413
64 -12.400[K] KOG2169 Zn-finger transcription factor  ali follow..  14  411.EDDIAMDR------------LNISLLDPLCKTRMTTPS-QDCTHLQC---LLSYLMMNEKCPVCSSNCPYDRLIVDDYFLDMLASYDVIKEEAFCISDDDDDDVVPATVNGTASCSSTNGNGLANEAAKKKPADDDIITLSDDDDEELNRGIMNSLNDSFSPGRHTASAELAAQKTPPQQKKKTK............................................................................................................................................................................................................................................................................................................. 603
65 -12.400[O] KOG2817 Predicted E3 ubiquitin ligase  ali follow..  23  326............EIFLPSSYHFHSVFTCPVSKEQATEPMMMSCGHVIVKESLRQLSRNGSKCPYCPNENVAADAIR........................................................................................................................................................................................................................................................................................................................................................................................................................... 395
66 -12.400[R] COG5109 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  23  326............EIFLPSSYHFHSVFTCPVSKEQATEPMMMSCGHVIVKESLRQLSRNGSKCPYCPNENVAADAIR........................................................................................................................................................................................................................................................................................................................................................................................................................... 395
67 -12.200[K] KOG4218 Nuclear hormone receptor betaFTZ-F1  ali follow..  9  40...........................CPVCGDKVS---LLTCEKGFCQNCIDK--TQRKRCPYCR-------FQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLM--CKMADQTLFSIVE--ELKVDDQMKLLQNCWSELLILVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALDYTMCNTEKFGQLLPEIRA................................................................................... 462
68 -12.000[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  18  185...................RKVDMVTLCSVCQR--SNRIVFGCNHQLC---IDDATVQDVDCMKCQYR................................................................................................................................................................................................................................................................................................................................................................................................................................... 246
69 -11.800[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  27  330...........................CNICGTSENDDQLLFCDHMYC---MSEPPEGSWSCHLCLD.................................................................................................................................................................................................................................................................................................................................................................................................................................... 376
70 -11.600[R] COG5236 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  34  59......................EENELCVICARKLTYVSLTPCHHKTCHICGFR-LYNKKSCLICRTENEE................................................................................................................................................................................................................................................................................................................................................................................................................................ 109
71 -11.500[K] KOG3815 Transcription factor Doublesex  ali follow..  17  1MNYGSPYLYMGGPVSQPPRAPLQRTPKCARCRN-VLSWL----GHKYCKDC---------TCEKCRVMAAQVALRRQQANES..................................................................................................................................................................................................................................................................................................................................................................................................................... 82
72 -11.200[O] COG3058 Uncharacterized protein involved in formate dehydrogenase formation  ali follow..  20  190...........................CPVC----SMPVSS-CETEWCSNC--WSLDDEQACDDCGTYLKILYQEKEPKVEAVADDLASLVLDARMEQE.................................................................................................................................................................................................................................................................................................................................................................................................... 292
73 -11.100[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  15  781.........................TRCDHCKQVLTEHLLTECDKK-CYRCLPRHIKHKDRCPLCHENFSPGE-----------EAWKA------HLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSKIPTPKGGLSKSSSRTYAKR........................................................................................................................................................................................................................................................................................................................................ 925
74 -10.900[K] COG5175 Transcriptional repressor  ali follow..  19  28......................DEEDYCPLCIEPMD-P--CPCGYQICQFCIRQNPELNGRCPACRRKYDDENVRYVTLSPEELKMERAKLARKEKERKHREKERKENEYT........................................................................................................................................................................................................................................................................................................................................................................................ 123
75 -10.900[S] KOG3899 Uncharacterized conserved protein  ali follow..  17  319............ADFDRNGAPLANGACCSNCY----------CRPMWCVECLARWLEQKCTCPMCRAKFCVLDV............................................................................................................................................................................................................................................................................................................................................................................................................................. 383
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Bourne PE, Allerston CK, Krebs W, Li W, Shindyalov IN, Godzik A.,Friedberg I, Liu T, Wild D, Hwang S, Ghahramani Z, Chen L, Westbrook J. The status of structural genomics defined through the analysis of current targets and structures. Pac Symp Biocomput. 2004;:375-86.