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Query: [S] COG5495 Uncharacterized conserved protein, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVQFDGLRSARLNIAILSTGRVGVALERADQVVVACSAVSHASRQWVQFRLPETSVASPPEVASSAELLLLAVPDCEFAGLMSGVAVTSVPRPGTIVAHTSWANGVGILAQLGKDGCIPLAIHPAMMFSGSDEDLSQCQLRDTYFGITKTDDVGYAIAQSLVLEMGGEPFCVVEYARILYHSVSPHVGNHIVTVLADALEVRRSALRGSELLGLGVPPACRGEVVDDQLDVIVERIVGSLARAACENTLQRGQAGLTKLVARGDLDALAGHLVALMRIGPELAQAYRVNALRKTQRAHAPYDVVEALAPLast
1 -102.000[S] COG5495 Uncharacterized conserved protein  ali  100  1MVQFDGLRSARLNIAILSTGRVGVALERADQVVVACSAVSHASRQWVQFRLPETSVASPPEVASSAELLLLAVPDCEFAGLMSGVAVTSVPRPGTIVAHTSWANGVGILAQLGKDGCIPLAIHPAMMFSGSDEDLSQCQLRDTYFGITKTDDVGYAIAQSLVLEMGGEPFCVVEYARILYHSVSPHVGNHIVTVLADALEVRRSALRGSELLGLGVPPACRGEVVDDQLDVIVERIVGSLARAACENTLQRGQAGLTKLVARGDLDALAGHLVALMRIGPELAQAYRVNALRKTQRAHAPYDVVEALAP 309
2 -18.800[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  17  1......MSHTKPSIAILGAGRVGSSLARAGYEVKVAGSGAVDKIALTAEILMPGAPSTADQAVKDADIVFLAVPLHKFRSVNPAT------LEGKIVIDTMPRSTSEIIAEFFAGSTMVKSFNHIGYHEIEQDAGTGRAI-----AYATDDVDAGAQVAQLIKSFGFVPLNIGA....................................................................................................................................... 178
3 -17.000[E] COG0287 Prephenate dehydrogenase  ali follow..  14  9............RIALIGIGLIGSSIARD-RHVVISTRSEDTLKRAEELALGTDYTVSAAEAVKDADLVIVSVPVGASESVAQQIAPY---LKPSAIVTDVGSTKASVIAQMAPENVHFIPGHPLAGTEKSGPDAGFAGLFRERWCIPGTDAAALERLKDFWRALGSRVDEMDAEH----HDKVLAIVSHLPHIIAYNI-VGTADDLETVTESEVIKYSASGFRDFTRLAASDPTMWRDVCLHNKDAILEM--ASLQRAIRWGEGDKLFELFSRTRSIRRSIIE......................... 291
4 -15.900[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  9  360......NDGSRLKIGIVGFGNFGQFLGKTMVK-HTVLAYSRSDYTDEAAKLGVSYFSDLDDFEEHPEVIILCTSILSTEKVLESLP-FQRLKRSTLFVDVLSVKERNLFLQTLPQDFDILCTHPMFGPESGKNGWNNLAFDKVRIGMDDRRKSRCNSFLDIFAREGCRMVEMSCAE----HDWHAAGSQFITHTVGRLEKLSLESTPIDTKGYETLLKLVENTAGDSFDLYYGLFLYNPNAMEQLERFHVA--ESLKTQLFGRLHSQHSHELAKSSSPKTTK........................... 636
5 -15.900[E] COG0345 Pyrroline-5-carboxylate reductase  ali follow..  10  2.........ENQKIGFIGAGKMGSALMQGTIK-IGASDVYEPFLKDLQAKLGIRVSTDNAVIVRESDILILAVKPQTLSSVLSNLKNE--ITSEKLVISIAAGVPLSTYEDALLEGTRVVRVMP-------NIAATVSEAASGIAPGKNATPEDLKAALEIFSAVG-TAVQVPESLMDAVTGLSGSGPAFIFPVIEAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETGMHPGELKDMVTSTIQGIHSLEEAGIRAAFMNAVIRASERSKELGKK................................ 270
6 -15.300[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  10  36.........KGKKIVIVGCGAQGLNQGLSGLDIS---AIAEKRASFQRATENGFKVGTYEELIPTADLVVNLTPDKQHSKVVADVMPL--MKKDSAFGYSHG-FNIVEVGEEIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVNDPKGEGMAIAKAWAAATGGHKSSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKLVADGKDPAYAGKLIQYGWETITEALKQGGITL------MMDRLSNSAKLRAFELAEQIKESLGFLYYKHMDDIIS................................ 309
7 -14.700[E] KOG3124 Pyrroline-5-carboxylate reductase  ali follow..  11  1...........MSVGFIGAGQLAYALARG--KIIASSPEMNLPTVSALRKMGVNLTRSNKETVKHSDVLFLAVKPHIIPFILDEIGAD--VQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRCMTNTPVVVQEGATVYAT-----THALVEDGQLLEQLMSSVG-FCTEVEEDLIDAVTGLSGSGPAYAFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLK-------DNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRV.. 290
8 -14.600[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  13  2.........STMKVAVYGAGNMAIEFAEAGHDVVLAEPARDMLDDAHWKVVGVTVTDNDAEAASEAEIAVLFTPGKKTFEIAKNITNH--LPEGAVIANTCTVSPLERELRRDRKDLGIASMHPAAV-PGTPQHGHYVIGGHSSSELDIATDEQISRCVELAESCGKVAYVVPADV----SSAVADMGSLVTAVTLSGVLDYYYVGTQIIRAPKEMVEKQILMTLQTIASLVETSGVNGMLKAMNPELLVRSAKSM---HLLEEQEELDAALNTLSDLDDEVNKWIEKGEIRHTDLVAAQALAKE.... 321
9 -14.100[H] COG1893 Ketopantoate reductase  ali follow..  11  2.........EKPRVAVIGSGSIGLYLKLANWPAL-LVTNRPEQADHLNKPISVTATPLSSFSAEEAEVGFITVKSFAVKALLPQLQRK---KWDGLVFFQNGMTHLEILRQIPARAICCGIVE---AKRESDVRVQHTGDGAIWIGDMVGDSKNFDPMWACLHNAGLKAQKVTNWQDKMERKLIANAANPLTGLFRVKNGALIENQLFSLLLKELVKEACVTLGREREVDEHLAYTRA-ICDKTANNLSSMYMDLTHH--RRTEIESITGYLIKEAAKKGIEIPNTSFVYHAVMGMDEEGRKVR..... 306
10 -13.100[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  13  2...........LKIGIVGCGFIGGQICRASAELYALCDSSESKALELAASLKTCKPMKIEELIRGVDLIIESASQNAVRFIVPQALKAGC----DVMILSVGALADEELRDTLFGLAK............................................................................................................................................................................................... 112
11 -12.600[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  14  1...........MQLGMIGLGRMGANIVKGGHDCV-VYDHDPDAVKAMAGTTGVASLRELSQRLSAPRVVWVMVPAGNTTAVIEELANT--LEAGDIVIDGGNT-DLRHEKLLFKKGI---------HLLDCGTSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGV-EVAPSEQGYLHCGPCGSGHFVMASLAEGLNILRNADVGTRVQHGDA............................................................................................. 225
12 -12.500[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  14  3............TIGFIGLGIMGAPMADAGYKVI-ASDHRSKPLADLVAK-GLKTVSGHAAVAKAADIIITMVPDPQVADVLFG---ASGLTRGKLVIDMS-IETKVFAGKINELGCDYLDA-PVSGGEVGAKA-------ASLTIMVGGEEKAFERAKPVFEKMGKNITLVGPNGV----QTTKVANQIVVALVAEALVFASKAGADPARVRQALMGILEVHGERMVKRTFAPGFRIELHQKDLNLALEGAKALGVSLPNTSTTQQLFNSCAANGGAREDHSALVRALERMAFEVGGAVAEVKGKAA. 305
13 -12.300[I] COG1250 3-hydroxyacyl-CoA dehydrogenase  ali follow..  13  4............TVGIIGAGQMGCGIAAAGYKVQLYVSSGKMSDEDRKRALSLIKGSGDINDLAQADLVIEAVTEDE-RKIYGQVCPV--MRPDAILATNTSSLSITRLASATDRPERFMGIH----FMNPVPVMKLVEL----VRGIATEEETFKAAKEFVAHLDKTVTVAED-------FPAFIVNRILLPMINEAIYTLYEGVGTVDA---------------------------------IDTAMKLGANHPMGPLQLADFIGLDTCLSIMQVLHDGLAD......................... 252
14 -12.100[I] KOG2304 3-hydroxyacyl-CoA dehydrogenase  ali follow..  11  24............NVTIIGAGLMGSGIANAKLNVT-VVDSNQSALEKAQQGIANKMSTNVSDSVKDADLVIEAIVENI-RKLFAEVEVA--AKPTTLITTNTSSLRLADIGLNLKDKSRFGGLH----FFNPVPMMKLLEV----VRHTETSDATFNQLVDYGKTVGKTTVACKD-------TPGFIVNRLLVPYMFEALRLYERGDASMED---------------------------------IDVAMKLGAGYPMGPFELSDYVGLDTCKFIMDGWHAQYPEEVAFTPSPLLNSLVDSGKNGRKSG. 302
15 -11.600[S] COG4408 Uncharacterized protein conserved in bacteria  ali follow..  8  3............KLLMIGTGPVAIQLALKSDYEIDMVGRASTSEKSKRLYQANRLYKDVKNVKGEYETVVMACTADAYYDTLQQLSLETLQSVKHVILISPTFGSQMIVEQFMSKFSQDIEVISFSTYLGDTRIVDKEA-KKLYMGSTHSNSTMCQRISALAEQLKIQLEVVESNSSLYVHPPLFMLIREMRLMWKEMMAILQAFRVPSVNLLQFMVKENYPVRPETLDEGDIEHF......................................................................... 301
16 -10.100[R] COG2344 AT-rich DNA-binding protein  ali follow..  8  83........DEMTDVILIGVGNLGTAFLHNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQSITDRLVALG............................................................................................................................................................................................................................ 169
17 -9.800[Q] COG4693 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis  ali follow..  10  1...MMPSASPKQRVLIVGAK-FGEMYLNAGLELVGLLAQGSARSRELAHAFGIPLYTSPEQITRMPDIACIVVRST-----------------------VAGGTGTQLARHFLTRGVHVIQEHPL-HPDDISSLQTLAQEQGCCYWVNT---RAGRTWLRDAQQLR------RCLAKTPPVVHATTSRQLLYSTLDLLLLALGV......................................................................................................... 178
18 -9.680[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  7  83............DVIEAHKEDPEKIMPQIREKVNEVAKELPKPPETHPEDLGFEITTDDREAVADADFIMTWFPKGDMPGIIDKFIDD--IKPGAIVTHAC-TIPTTKFYKIFEETLNVTSYHPGAV-----PEMKGQVY----IAEGYASEEAINTLFELGQKARGNAYRLPAELSALTAITYAGILSYRDSVTQVLGAPAGFAQMMAKESLEQITALMEKVGIDKMEEHLDPGALLGTADSMNFGASADILPTVFEILEKRK............................................. 346
19 -9.470[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  10  2..........KQHIGYLGMGIWGFCLANKGYPVV-AWSRNPDLIKQLQEE-NLSFTTDMKEAIHNAFMIVEGVTSAGIRPVAEQLKQI--TDLSVPFVITSKGIEQNLLSEIMLEVLGDSVTPYLGYLSGPSIAKEVLNGSPCSVVVSAYDSQTLKQIHEAFSLPTFRVYPNTD-------IKGAALGGALKNVIAIACGIAEGLSFGNNAKAGLVTRGLHEMRKLAAIMDCKP--------ETLNGLAGLGDLCVTSESSRNTFEQAKAKIGMVVEGAYTALSAYQVAKHHKIDM............. 301
20 -9.170[R] COG1832 Predicted CoA-binding protein  ali follow..  12  18............RIAVVGLSMVSKAMQDAGYEIIPVNPT-------IDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDA----PVFWAQQGLVNEEAYQMLKEKGRTV.............................................................................................................................................................................................. 121
21 -9.140[M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase  ali follow..  11  8...VEKFKSRQALIGIVGLGYVGLRYNAIGFDVLGI--EHIPQAKIAKARASGFEATTDFSRVSECDALILCVPTSFVINTTDALKPY--LRVGQVVSLESGTTEEELLPRVQEGGLVVGRIYLVYSPEREDPGNPNFETRTIPKVIGGHTPQCLEVGIALYEQAIDRVVPVSSTKAA--EMTKLLENIHRIGLVNEMKIVADRMGIDIFEVVDAAIPIDPFYLTWKAREYGLHTRFIELSGEVNQAMPEYVLGKLMDGLNEAGRALKGSRVLVLGAYKKNVDDMRESPSVEIMELIEAKGGMVAYSDP 367
22 -9.130[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  11  2..........SADFGLIGLAVMGQNLIDHGFTVC-AYNRTQSKVDHFAKGKSIIGATSIEDFISKLKVMLLVKAGAPVDALINQIVPL--LEKGDIIIDGGNSDSNRRYEELKKKGI---------LFVGSGVSGGEEGARYGPSLMPGGSEEAWPHIKNIFQSISAK----SDGEPCCEWVGPAGAGHYVMQLICEAYDIMKRLGGFTDKEISDVFAKWNNGVLDSFLVEITRDILKFLVEKIMDTAGQKGTGKWT.................................................... 265
23 -9.120[Q] COG4569 Acetaldehyde dehydrogenase (acetylating)  ali follow..  8  2.........SKRKVAIIGSGNIGTDLMIK-LEMAVMVGIDPQSGLARARRMGVATTHEGVIGLADIDIVFDATSAGAHVKNDAALREAK---PDIRLIDLTPA--------------------AIGPYCVPVVNLEANVDQLNVNMVTCGGQATIPMVAAVSRVARVHYAEIIASIAS---AGPGTRANIDEFTETTSRAIEVVGGAAKGKAIIVLNPAEPPLMMRDTVYVLSDEASQDDIEASINEMAEAVQAYVPG--FSGLKTAVWLEVEGAAHYLPAYAGNLDIMTSSALATAEKMAQSLARKA. 312
24 -9.070[G] COG0362 6-phosphogluconate dehydrogenase  ali follow..  12  2........SVKGDIGVIGLAVMGQNLIDHGFKVV-AYNRTTSKVDEFAKGTNIIGAYSLEDLAAKLEKPRKVMLMDVVDQFIEALLPH--LEEGDIIIDGGNSDTNRRVKALAEKGI---------RFIGSGVSGGEEGARHGPSIMPGGNQEAWQYVKPIFQAISAK---TEQGEPCCDWVGGEGAGHFVMQLICEAYQFLKEGLGLSYEEMQAIFAEWKNTELDSYLIDITTDILGYLVEKILDTAGQKGTGKWT.................................................... 268
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;