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Query: [O] COG5549 Predicted Zn-dependent protease, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNKKIKLWGWCLALFLLTLLLVSLPAIANNGSKQALPELQIHPLPPELVDLGISLENRSLLGDDGTDYFSQVQPSPLGYLLWSKFPVTVAVDYPPGLTPGSAAQKRYYTWQQAIKTAIADWQEFFPLTIVENTTEADITIFYREPPLPRIVDPETGLVSFGRARTAQANYEFYWTDTSPPQLRHRMAIAIKPGLAPLSLQGTARHELGHALGIWGHSDHKEDALYPAQTADVPAISPRDLRTLYRLYQQPTRLGWSVLVSNLast
1 -105.000[O] COG5549 Predicted Zn-dependent protease  ali  100  1MNKKIKLWGWCLALFLLTLLLVSLPAIANNGSKQALPELQIHPLPPELVDLGISLENRSLLGDDGTDYFSQVQPSPLGYLLWSKFPVTVAVDYPPGLTPGSAAQKRYYTWQQAIKTAIADWQEFFPLTIVENTTEADITIFYREPPLPRIVDPETGLVSFGRARTAQANYEFYWTDTSPPQLRHRMAIAIKPGLAPLSLQGTARHELGHALGIWGHSDHKEDALYPAQTADVPAISPRDLRTLYRLYQQPTRLGWSVLVSN 261
2 -44.200[OW] KOG1565 Gelatinase A and related matrix metalloproteases  ali follow..  19  23.LAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAFQEAELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTLPP-------HTARAALRQAFQDWSNVAPLTFQEQAGAADIRLSFGRQSSYCSNTFDGPGRVLAHADIPE-LGSVHFDEDEFWTEG---------TYRGVNLRIIAAHEVGHALGL-GHSRYSQALMAPVYEGPHFKLHPDDVAGIQALYGKKSP......... 260
3 -13.000[S] COG4412 Uncharacterized protein conserved in bacteria  ali follow..  8  146.............VILIEFPDLPHNTLTPQDTDMYYKDYTTSHYQDMIFGPNGYSGPHNENLVSLKEYYNQQS---------GSYDIGYKAQHPAAYYGKNQGSDNSPRARDLVKEALTEVAKHIDLKQFDVKDPYDLMIIHSGMGEEAGGGSIGTDAIWSHSSKVYDMDN---TTKPWKIPGTDMSAYPYTIMPEDGAAGVFCHEFGHDLGL-------------------------D------EYDTQYSGK....... 368
4 -12.900[R] COG1913 Predicted Zn-dependent proteases  ali follow..  12  14................................................................PGDVLAFLQNSLSGFYAKYGIEVRLVGGLSLSKFQHAFDFERRQFLARYFLPVLSYIRKDFNAKAALGVVNVDIYELGLNFIFGLAHPGLRVAIISLYRLYPEFYGN-----------------PPDRKLLKERALKEAMHELGHVFGL-EHCPNPKCVMHFSNS-----IIDTDIKSWMYCEKCLRKLEKNL.... 183
5 -10.700[W] KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases  ali follow..  10  255......................................YEHIRMKEGNNDPIRTREEIVSLFYNHIKAVNEIYEGTN-----GIKGLHFVIQRTSTPDSCDRGRAKTDSDNPFCEENVDVSN-FLNLNSQRNHSAFCLAYALTFRDFVGGT-ASPQFNTAGGICQVHQRYNEGSRGWVYRSLNTGIVTLVNYGNRARVSQLTLAHEIGHNFGS-PHDFPAECIMFASATSNNGKFSPCSVKNISAVLAV............ 482
6 -10.600[S] COG3824 Uncharacterized protein conserved in bacteria  ali follow..  15  73....................................................................................................GELAPSMEEMEFLALEAYAH----LPEDFRKLTGEIVIQIA-DEIMDDLSLETPFDLLGLFEGRGIAERWNPQTGEGPNRITLYRRAMLDYWAENEETLGDVLIHEIGHHFGL-----SDDDM...................................... 193
7 -9.840[S] COG3091 Uncharacterized protein conserved in bacteria  ali follow..  10  1.................................................................................MSTLRIPIALQQAVMQCLRHYLQLANQHLGTAYPEPKVNYHQRGTNAGSAYLQSFEIRLN-----------------------------------------------VLLLENKQPFIDEVVPHELAHLL--APHGKEWRWMME-VPASRTHQFEVASVRSKTFNY.............. 129
8 -9.700[R] COG2321 Predicted metalloprotease  ali follow..  10  73....................................................................................................SPNEDEAAKFTSVILATTEDWGQQFEKMGKTYQQPKLVMYR------GMTRTGCGAGQSIMGPFYCPADGTVYIDLSFYDDMKDKL-----GADGDFAQGYVIAHEVGHHVGIEPKVRQLQQNATQAEVNRLSVRMELQADCFAGVW.............. 213
9 -8.660[O] KOG3607 Meltrins, fertilins and related Zn-dependent metalloproteinases of the ADAMs family  ali follow..  10  281................................................LKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQM----EFSKYRQRIKQHADAVHLISRVTFHYKRSSLSYFGG----VCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGI-QWEPSSRKGCIMEETGVSSKCSILEYRDFLQLFNRPTKLFEPTECGN 507
10 -8.440[R] COG0319 Predicted metal-dependent hydrolase  ali follow..  12  1....................................................................................MSIELDLQLAVENEHGLPSEAEFALWLTRTITPFQA-QAEVTVRIVDEAESHALNLNYRGKDKPTNVLSFPFEAPSGMEMDLLGDLVICRQVVEREAIEQNKPL-------QAHWAHMVVHGSLHLLGYDHIEDDEAEEMESLETEIMQEMGFTD-------YLAEKE......... 154
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 2 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li Z, Ye Y, Godzik A. Flexible Structural Neighborhood--a database of protein structural similarities and alignments. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D277-80.