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Query: [S] COG5594 Uncharacterized integral membrane protein, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSDSSSSSTSAFVSSLVFNFAIFCAFIGLFLCLRPREKHVYQPRCIIDTQPKEEKPEPSPSSPFGLFAYVVKRSETYLIQYAGVDGYFFIRYLFTFGALCILGCLVLFPILLPVNATNGVGEKGFDILSFSNVKNHNRFYAHVFLSWLFFGFTIFIIYRELRYYVIFRHAMQSSGLYNNLPSSSTMLLTELPNSVLNDEETLHELFPNASEFTCVRDLKKLEKKVKKRSDLGNKYESTLNSLINKSVKKHNKLVKKHKPLPSTLDYTAYVKKRPTHRLKFLIGKKVDTIDYCRDTIAELDEVVDKLQTSLEERKKVGSVFIRFRSQTDLQTAYQAFLYSKKFRKYRFGRALVGIAPEDIVWSNLDLSMYTRRGKKTISNTILTLMIIFWAFPVAVVGCISNVNYLIEKVHFLKFIDHMPPKLLGIITGILPSVALSILMSLVPPFIKFLGKFGGALTVQEIENYCQNWYYAFQVVQVFLVTTMTSAATSAVVQVIKEPASSMTLLASNLPKASNFYISYFLLQGLSIPGGALLQIVTLLLSKVLGRIFDNTPRKKWNRWNQLSAPSWGTVYPVYSLLVTIMICYSIIAPIIIGFAAVAFVLIYFAYSYNLIYVLGHNADAKGRNYPRALFQVFVGLYLAEVCLIGLFVLAKNWGATVLEAVFLGFTVACHLYFKYKFLPLMDAVPISAIESVSERPEIKYPMDLGTSEMKNVGRAYPEILEKLSSSSGSDEFLETSSRTSENTKEKIDKDDEGFAITNISSVHKMPSFVLSYFSDLAASNRILTGFDRVLQLLPSFYDIPVRVRNVQYVSPALKATPPSVWIPKDPLGLSTYAIEDARGKVDIFDDNTTFNEKGNLQYTGPPPDYDEAIRSLast
1 -190.000[S] COG5594 Uncharacterized integral membrane protein  ali  100  1MSDSSSSSTSAFVSSLVFNFAIFCAFIGLFLCLRPREKHVYQPRCIIDTQPKEEKPEPSPSSPFGLFAYVVKRSETYLIQYAGVDGYFFIRYLFTFGALCILGCLVLFPILLPVNATNGVGEKGFDILSFSNVKNHNRFYAHVFLSWLFFGFTIFIIYRELRYYVIFRHAMQSSGLYNNLPSSSTMLLTELPNSVLNDEETLHELFPNASEFTCVRDLKKLEKKVKKRSDLGNKYESTLNSLINKSVKKHNKLVKKHKPLPSTLDYTAYVKKRPTHRLKFLIGKKVDTIDYCRDTIAELDEVVDKLQTSLEERKKVGSVFIRFRSQTDLQTAYQAFLYSKKFRKYRFGRALVGIAPEDIVWSNLDLSMYTRRGKKTISNTILTLMIIFWAFPVAVVGCISNVNYLIEKVHFLKFIDHMPPKLLGIITGILPSVALSILMSLVPPFIKFLGKFGGALTVQEIENYCQNWYYAFQVVQVFLVTTMTSAATSAVVQVIKEPASSMTLLASNLPKASNFYISYFLLQGLSIPGGALLQIVTLLLSKVLGRIFDNTPRKKWNRWNQLSAPSWGTVYPVYSLLVTIMICYSIIAPIIIGFAAVAFVLIYFAYSYNLIYVLGHNADAKGRNYPRALFQVFVGLYLAEVCLIGLFVLAKNWGATVLEAVFLGFTVACHLYFKYKFLPLMDAVPISAIESVSERPEIKYPMDLGTSEMKNVGRAYPEILEKLSSSSGSDEFLETSSRTSENTKEKIDKDDEGFAITNISSVHKMPSFVLSYFSDLAASNRILTGFDRVLQLLPSFYDIPVRVRNVQYVSPALKATPPSVWIPKDPLGLSTYAIEDARGKVDIFDDNTTFNEKGNLQYTGPPPDYDEAIRS 871
2 -116.000[R] KOG1134 Uncharacterized conserved protein  ali follow..  17  2......ATINDIGVAAAINIVTAFAFLLAFAIFRIQNDRVYFPKWYLKGLRSSSIQFRSYIRFLNWMPEALKMPEPELVDHAGLDSVVYLRIYLLGLKIFFPIACVAFTTMVPVNWTNKGSFSDIDKLSLSNIPNGSRSLSHFPGIIIFGFSIVYISDLISELMMVDLLLTQAVHDATKLSELVLTRKQMQN----------------------------------------------------------------------------------------LLDYNINKHMRNLSNRPVIKISEEKQRLRTGTKSIVPAAFVSFKSRWGAAVCAQTQQTRNPTE----WLTEWAAEPRDIYYDNLALPYVDLKIRRLIVGVAYFFLTFFFMIPIAFVQSLANIEGIEKAFPFLKPLIEVYKLLKSIIQGFLPGIALKIFLLFLPRILMQMSKFEGFVSTSSLERRAATRFYMFQFINVFLGSIVTGTAFQQLNSFLNQSNDIPKTIGVSIPMKATFFITYIMVDGWAGVAGEILRLKPLIIYHLKNSFLVRTEKDRE-EATDPGTIGFNTAVS----------------PILLPFILVFFGLAFVVYRHQVINVYNQKYESAGKFWPDVHRRVVTALVVSQLLLMGLLSTKHASKSTPLLLVLPLLTIGFHKHCKNRYQPAFVTYPLQEAMIKDTLDRIREPNLNLKAFLRDAYAHPEFRVGEDPEPEEKLESDMSPPDLVATKRWSWRNTPLPSKDSCREIP............................................................................................................. 680
3 -8.860[R] COG2409 Predicted drug exporters of the RND superfamily  ali follow..  7  246LGHSGAIGLTTFAVSLLTSLAIAAGTYGIFIIGRYQ-------EARQAGEDKEAA-----------YYTMYRGTAHVILGSGATFCLSFFQTLGIPCAVGMLVAVAVALTLGPAVLHRLLKVRGWRRVGTVVVRWPLPVLVATCAIALVGLLALPGYKTSYNDRDYLPDFIAADRHFSQARMKPEILMIESDHDMRNPADFLVL---------LAKGIFRVPGISRVQAITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDMLKQADEMATTIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDFWRPIRSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDRLMPQMVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAFDAYLPPEVFK-FQRAMKSFLSSDGHAARFIILHRGDPQSPEGIKSIDAIRTAAEESLKGTPLEDAKIYLAGTADISEGAQWDLLIAAISSLCLIFI--MLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHILAIHLHWLVLAMSVIVLLAVGSDYNL----------------LLVSRFK---GIIRSMGGTGKV--LVFAVTMASMAVSDLRVIGQVGT-------TIGLGLLFDTLIVRSFMTPSIAALL.............................................................................................................................................................................................. 928
4 -8.770[P] KOG4505 Na+/H+ antiporter  ali follow..  9  89..........................................................................................................................................................................................................................................................................................................................................................................ELPRAYMLRHWRSMFVMLLPVMIFGWLVSTGFMYALIPRLSFLESLA------------IAACITATDPVLASSIVGK-VPGHLRNMLLAESYLIIEKPARHAGRDWVCIIILYECTFGCVLGAIIGVIARKM-----IKFSERRGLMDRESFLVFYFVLALFCGGIGTIIGVDDLLVSFCAGAAFSWDSWFSKKTEES---SNVIDLLLNLSFFVYVGAIFHMPHMDLSVWRLVVLAICILIARRIPAVLLFKSFVPDIINWREALFAGHFGPIGVGALYTCLVARAENWYCIQVMWPVVCFLVLSSIIVHGSSIAFFMLGKRINTLALSFTRTRDSHFAFNLPRVRQGQSLPIKRVDALRSSANSIASSIRRRHPVNIQEDEDADISTVSLPEAAHLREERAESPRGGHYDAEEFPSEDYESRQPRRSNEEDREEEMNPGDETYLIGEDL-------VVEDSQGNIISHTSSRDANGPSIDEKLAQGDPKAKSFGRKFRSFLRRSYD 617
5 -8.550[A] COG5183 Protein involved in mRNA turnover and stability  ali follow..  10  605MSNPTRRLIFQILFALKCTFKVFTLFLAGFPIL---FCPILASNSRMLWVPSICAIWPPFSLFVYWFAKYIGMIRKNIIR--GV--LFFIRMSIQLSRLCLSMFIYAIFIVLGFGFHTRIFFPFMLKSNLLSVPEAYKPTSIISWKFNTILLTLYFTKRILESSSYVKPLLERYWKTIFKLCSRKLRLSSLGKDTPTERNLFYKYIAAKNAEWSNQELFTKPKTLEQAEELFGQVRDVHAYFVPDGVLMRVPSSDIVSRNYVQTMFVPVTKD----------DKLLKPLDLERIKERNKRAAGEFGYLDEQNTEYDQYYIVDFRLRYMTLLG--------------------------LVW------------------FASILMLGVTFISQALINFVCSFGERNKVYVAWKELSDISYSYLNIYYVCVGSVCLSKIAKDILHFTEGQNTLDEHAVDENFNSIFDSMLVKYNLMVFIAIMIAVIRTMVSWVVLTDGILACYNYLTIRVFGNSSYTIGNSKWFKYDESLLFVVWIISSMVFGTGYKSLKLFFRNRNTSKLNFLKTMALELFKQGFLHMVIYVLPIIILSLVFLRDVSTKQIIDISHGSRSFTLSLNESFPTWTRMQDIYFGLLIALESFTFFFQATVLFIQWFKSTVQNV................................................................................................................................................................................................................... 1301
6 -8.310[T] KOG4193 G protein-coupled receptors  ali follow..  10  277........................................................................................................................................................................................................................................................................................................TENASMKLGTEALSTNHSVIVNSPVITAAINKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSRTMTGYWSTQGCRLLTTNKTHTTC--------SCNHLTNFAVLMAHVE-VKHSDAVHDLLLDVITGILLSLVCLLICIFTFCFFRGL--------QSDRNTIHKNLCISLFVAELLFLIGINRTDQPIACAVF------------------AALLHFFFLAAFTWMFLEGVQLYIMLVEVF---------ESEHSRRKYFYLVGYG--MPALIVAVSAAVIWSFIGPLIIMLNVIFLGIALYK-KPESGCLDNINYEDNRPFIKSWVIGAIALLCLLGLTAFGLMYINESTVIMAYLFTIFMFIFIFHCVLQKKVRKEYGKCLRTHCCSGKSTESSIGSGKTSGSRTPGRYSTGSQSRIRRMWNDTVRKQSESSFITGDINSSASLNREPYRETSMGVKLNIAYQIGASEQCQGYKCHGYSTT...................................................................................... 758
7 -8.300[U] KOG1278 Endosomal membrane proteins, EMP70  ali follow..  10  283...............................................................................................................................................................................................................................................................................................SVKFVASDTTRWDKYLHIYDPQIQWFSLINFSVIVILLSSVVMHSLLRALKSDLARYNELNLDNEFHE--DSGWKLGH-PSKSMLLSILVGSGMQLFLMVMCSIFFAAVGLVSPVSR-GSLPTVMFVLYALFGFVGSYASMILTPILLPGAIFLLIVIMNFFLLFAH--SSGVIPARSLFFIILLWFLVSVPLSFAGSIVAHKQCNWDEHPTKT-NQIARQIPYQPWYLAQATLIAGIFSFGSIAVELYFIYSSLWFNKIF----------------YMFGFLLFSFLLLTLTTSLVTIL--------ITYYSLGCSIYTFIHSI-LFTKFKLGGVI-------LYLGYSLIISALCCVVTGAIGFFSSMFFIRKIYSAI............................................................................................................................................................................................................ 669
8 -8.290[O] KOG2292 Oligosaccharyltransferase, STT3 subunit  ali follow..  10  1..............................................................................................................................................................................................................................................................................................................MNRTPKMLNSKVAGYSSLITFAILLIAWLAGFSS---RLFAVIRFESIIHEFDP----WFNY------RATAYMVQNPGLMITSGGIHWLLHVLNIPVHIRDICVFLAPIFSGLTS--LLTKELWSAGAGLFAASFIAIVPGYISR--SVAGSYDNEGIAIFALQFTYFLWVRSVYFYMVSAWGGYVFIINLIPLHVFVLLIMGRYSPRLLTSYSTFYILEHMAALGVFVLLMAVATLRHLQSVLSRNEFRKLFIVGGLL-----------VGVGVFVAVVVLTMLGVVAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTTWFSFFFDLHILVCAF---PVGVWYCIKQINDERVFVVLYAISAVYFAGVMVRLTPVVCMLAGVAFSGLLDVFLQEDSSKRMGTAISAATEVDEAEDSIEKKTLYDKAGKLKHRTKHDAQQDTGVSSNLKSIVILAVLMLLMMFAVHCTWVTSNAYSSPSIVLAFHNSQDGSRNILDDFREAYYWLSQNTADDARVMW----DYG-----IAGMANRTTLVDNNTW...................... 578
9 -8.180[R] KOG2296 Integral membrane protein  ali follow..  10  1......MGTISLAVQLFIVFLLTSYLLNKYSTIRKQNPIVTIS-------------------FIGWYFSL------IIVFVLPLDGYVPDDVLFNLWRVVYWSAQLLTWLILPLSYVTAGNFTILGKIRAA-VINNALYYA-IYSLCFLAILIYAMFKGVSINIENLKVIVVSASNTWGLFLLVVLLLVELPRSLWHHGNRHYRLR------KTYFDIEKLASEKSEAEENVKDIYKKVRVLFNSMKNDSNGQRRKVRTILSKFSDDVIDNLFPSRQVIDNAHLDESG-PCSEAKLISLHKKTIYAVQTLNNAT------AQWKVLVDRALFLENLAFSESNGYNLELSRNTCVPIGVRRFWYTRLQTPFCRILGIVTVFMTFFVLFSECTFFVVSYTLSPAAFVTEYASTRFHYKYTQFVAFGIIVYLITSAYFTIFRLQIYKYYHLDPNGHTDENSILFSAILLCRLTPPICLNFLGMIHMDSHISMAKSFGIETQFTKLMGHLDVIPILAKGINIYLPICIILLCAIHYYRVGAYVLHNI........................................................................................................................................................................................................................................................................................................................................ 538
10 -7.970[E] COG1177 ABC-type spermidine/putrescine transport system, permease component II  ali follow..  12  1.............................................................................................................................................................................................................................................................................................................................................................................MNGRNPLWTFSGVRQAAWLFFAFLYIPILVLVVLSFNSGQSATLWESFSLKWYAVVANDILRAAKNSLLVATLATLASTVLATLAAL----GMRGRAFRGQTLMNGVLGLPLLVPEIVTAVATLMFFSFIGLKLSLFTILIAHIVFCIPFAY-LPIRARLEGLDPRLAEAAADLYASPWKAFWK--------------------------------ITLPLLMPGVLSGAMLAFIISMDDFVITY-FVAGAGATT-------------LPVYIFSSIRMGISPKINAISSIILMISIAFVALSYYLGQRRR................................................................................................................................................................................................... 262
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Dunbrack RL Jr, Dunker K, Godzik A. Protein structure prediction in biology and medicine. Pac Symp Biocomput. 2000;(12):93-4.