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Query: [M] COG5632 N-acetylmuramoyl-L-alanine amidase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKKLVKSAVVFASLALIGTSATLITEKASASSIETVQKVDDQSIYIPQGIRDGTATEEHDGFEDETNSVLKTTSLLRATTGYPDVNAYIKSNKFSTASIEKQLKSQFPKFNYRNGYGKPEGVVIHETANNSSTIEGEISYMSRNYNNAFVHSFVDKSRIIQIHPTENGVWGAGQYANARFIQVELVRSKTFDEFARSINNYAYYAAYLLDQYKLPVDSAHSDGKGTIWSHDAVTRYLGGTTHTDPVGYFNQWGYNFNSFVTLINEKYKAIQASKVTYDKIEYDKGVTAYARVKTAPGNAVWTRPYRTEGSKLVNQLSVYQGKNMRILREAKTPITTWYQFSIDGKTIGWVDTRALDTFYKQSMEKDANLTRYVASNKTGEAYYKVPVVDADVKWGTIGTYKSEKLTVDKQATVEGQLWYRVKAGSTFIGWTKASNLTATSPFDKIEYDKGVTAYARVKTAPGNAVWTKPYRTEGSKLVNQLSVYQGKNMRILREAKTPITTWYQFSIDGKVIGWVDTRALDTFYKQSMEQSTNLTRYVTANKTGEAYYKVPVADSDVKWGTLATYKNEKLTVDSQATVEGQLWYRVRTSTTFIGWTKAENLTTTPPFDAIEYDKGVTAYARVKTAPGNAVWTKPYRTEGSKLVNQLSVYQGKNMRILREAKTVITTWYQFSIDGKVIGWVDTRALDTFYKQSMEKDTNLTRYVIANKVNEAYYKVPVVDADVRWGTLAAYKGQKLTVDKQATVEGQLWYRIRTSSTFIGWTKASNLSATKLast
1 -200.000[M] COG5632 N-acetylmuramoyl-L-alanine amidase  ali  100  1MKKLVKSAVVFASLALIGTSATLITEKASASSIETVQKVDDQSIYIPQGIRDGTATEEHDGFEDETNSVLKTTSLLRATTGYPDVNAYIKSNKFSTASIEKQLKSQFPKFNYRNGYGKPEGVVIHETANNSSTIEGEISYMSRNYNNAFVHSFVDKSRIIQIHPTENGVWGAGQYANARFIQVELVRSKTFDEFARSINNYAYYAAYLLDQYKLPVDSAHSDGKGTIWSHDAVTRYLGGTTHTDPVGYFNQWGYNFNSFVTLINEKYKAIQASKVTYDKIEYDKGVTAYARVKTAPGNAVWTRPYRTEGSKLVNQLSVYQGKNMRILREAKTPITTWYQFSIDGKTIGWVDTRALDTFYKQSMEKDANLTRYVASNKTGEAYYKVPVVDADVKWGTIGTYKSEKLTVDKQATVEGQLWYRVKAGSTFIGWTKASNLTATSPFDKIEYDKGVTAYARVKTAPGNAVWTKPYRTEGSKLVNQLSVYQGKNMRILREAKTPITTWYQFSIDGKVIGWVDTRALDTFYKQSMEQSTNLTRYVTANKTGEAYYKVPVADSDVKWGTLATYKNEKLTVDSQATVEGQLWYRVRTSTTFIGWTKAENLTTTPPFDAIEYDKGVTAYARVKTAPGNAVWTKPYRTEGSKLVNQLSVYQGKNMRILREAKTVITTWYQFSIDGKVIGWVDTRALDTFYKQSMEKDTNLTRYVIANKVNEAYYKVPVVDADVRWGTLAAYKGQKLTVDKQATVEGQLWYRIRTSSTFIGWTKASNLSATK 770
2 -28.800[V] COG3023 Negative regulator of beta-lactamase expression  ali follow..  16  30..........................................................................................................SPNFGPRRDGKQPVFLILHYTGLA--TAKEAMDVLKSPEMEVSAHYVVHDGRVVQMVSEKARAWHAGKSFNSASIGIEIVNPGVLENYDAQIEAVIRLCQDICKRHEIRPENVLAHSD.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 157
3 -19.500[NU] COG1705 Muramidase (flagellum-specific)  ali follow..  19  3...............................................................................................................................................................................................................................................................................................................................................................................................................................................RKCQLIMKKKFTQILLASAIVSSTLLPFANVGAAEASQTAVSQAGMTLSQQQFIQSIASDAQDLQKEEKILTSVTLAQAILNWGESGLSTSANNSMGTQEFSNGKAYHTQADFRKYPDKKSSDLYSAVIGETDYKKAAHAIQDAGYATDPTY-----AEKLISTIETYNLDD-QIYDTVTSSESQLAYAEITKPANEIIWTKPYNTKGAEQVGSAKDYQSKTLRITQKAVTEKGTWYQLQDQGKSIGWINSNTVTIFYTPKNETNMKLDK--YVTDSDQKIYAYPVEDNSKVVADLNDYLGQELDIDRRADVKNEYWYRIKSDGKIIGWSKAGGFAENN 367
4 -16.200[S] COG3807 Uncharacterized protein conserved in bacteria  ali follow..  11  1........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MTAGTAQAQAAKGPSGLPLPRFVSLKAKSVNLRIGPSVDYAVAFRYLK-SGVPVEIIQE----YDNWRRIRDADGTEGWVNQALLSGDRTALAAPWMRSKGEGVFVN------RRDPQGTASIVARVE--PGVMLHIGEC----NGDWCHAETQGVE-GWIAQSEIWGAY 153
5 -13.700[S] COG4991 Uncharacterized protein with a bacterial SH3 domain homologue  ali follow..  13  2......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KLSARASIFTLALLVSTNAYASSAIVTSTVNLRTGP--GTQYGTIGAIPN--GVGIMVAG--CTRGYGWCQVSYGGMT-GWAASRYIAIQTGNGYTTNDNFGSTAAAVGIPLIAGIVIGGPACVSAAGGKAQRKTGPPDSLLSGASPD-WKRVKGISAEIPYWEHGFLKRQT 243
6 -10.400[T] COG3103 SH3 domain protein  ali follow..  16.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ATAVSHAEETRYVSDELNTWVRSGP--GDHYRXVGTVNA--GEEVTLLQT--DANTNYAQVKDSSGRTAWIPLKQLSTEPSLRSRVPDLENQVKTLTDKLTNIDNTWNQRTAEMQQKVAQSDSVINGLKEENQKLKNEWFMVLGLGLLLGWMN........ 206
7 -10.200[T] KOG3601 Adaptor protein GRB2, contains SH2 and SH3 domains  ali follow..  10  10..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QATESDELAFNKGDTLKILNME--DDQNWYKAELRGVE-GFIPKNYIRVKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEF-SVSVNYGDQVQHFKVLREASGKYFLWEEKFNSL----VDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPH---WWRGRSCGR-VGFFPRSYVQPVH 216
8 -10.200[T] KOG4348 Adaptor protein CMS/SETA  ali follow..  12..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AQHDDELTISVGEIITNIRKEDGG---WWEGQINGRR-GLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSELPQNDDELELKVGDIIEVVGEVEEG---WWEGVLNGKT-GMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVG-WWEGELNGRR-GVFPDNFVKLLP 327
9 -9.910[R] COG5263 FOG: Glucan-binding domain (YG repeat)  ali follow..  13  19............................................................................................................................................................................................................................................................................................................................................................................................................................................................................LLATNTVFANTTGGRFVDKDNRKYYVKDDHKAIYWHKIDGKTYYFGDIGEVVGWQYLEIPGTGYRDNLFDNQPVNEIGLQEKWYYFGQDGALLEQTDKQVLEAKTTGKVYGEQYPLSAEKRTYYFDNNYAVKTGWIYEEGH-----NKLGNFGDDSYNPLPIGEVAKGWTQDFHVTIDIDRSKPAPWYYLDASGKMLTDWQKVNGKWYYFGSSGSATGWKYVRGKWYYLDNKNGDMK---------------------TGWQYLGNKWYYLRSSGAMVTGWYQDGSTWYYLDPSNGDMGWTKVNG..... 308
10 -9.220[S] KOG2995 FOG: SH3 domain  ali follow..  10  11..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SGEATDLKFKKGDLILIKHRIDNN---WFVGQANGQE-GTFPINYVKVSVPLPMPQCIAMYDFKMGPNDEE--------------GCLEFKKSTVIQVMRRVDHN---WAEGRIGQTIIAFVELNAAAKKLLDSGLHTHPFCHPPKQQGQRALPPVPVIDPTVVTESSSGSSNSTPGSSNSSSTSSSNNCSPNHQISLPNTPQHVVASGSASVRFRDKGAKEKRHSLNALLGGGALALFP-----KPRQTDELELKKGCVYIVTERCVDG---WFKGKNWLDITGVFPGNYLTPLR 342
11 -9.180[T] KOG4226 Adaptor protein NCK/Dock, contains SH2 and SH3 domains  ali follow..  10  14..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AQEEQELTIKKNERLKLLDD----SKNWWKVMNDSNSVGFVPSNYVRKESIVDKAKGTIKGLARGRNRSSDPEPEERLNGIARLAFSLNN-KGDFVYVVEKSTDG---WWKGEAPNGGVGWFPSNYVEEVEASTNGNQGSIENRNPAAAAVPAPIMMQAPPPKLDASSSEELSFKKGERLEIVDHPEHDPD-WWMARNASGTTGLVPRNYIEVVVNDSSSSKASHQDFAPQYSGNGEIPMEQQPWSESNPGDLSISMRGIERNKHKVQNVDGLLKIGNRT-ALINHYTTSPIFSSP 386
12 -9.020[K] KOG3766 Polycomb group protein SCM/L(3)MBT (tumor-supressor in Drosophila and humans)  ali follow..  5...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LSASNMQDPSSSPL--LGSANGNGDLDSEEGSSLEETGFNWGEYLEETGASAAPHTSFKHVEISIQSNFQPGMKLEVANKNNPDTGQLLLLRYCG--VGWCTQNNKVLMPPDAIKEKYTDWTEFLIRDLTGSRTAPANLLEGPLRGKGPIDLITVGSLIELQDSQNPFQGGRLRLRYVG--VGWCQENKYRMDPPSEIYPLKMASEWKCTLEKSLIDAAKFPLTVGMKLETVNMCEPFYISPASVTKVFNNHFFQVTIDDLRVQWCLKNGVS... 368
13 -9.010[S] COG4922 Uncharacterized protein conserved in bacteria  ali follow..  6MNFVTRRLAIAALALAPALLAAPVLAETAKRDLAQEETNRKLVIDFYDTVFNKHEVAKGAAVIVDSYKQHNPMVPDGKKPFVDYFTGFFKENPQAKSRIVRSATDG-------------DLVYLHITDKEGARGAAIVDIFR-----------VTDGKITE--------WDVEKAANNNTM............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 162

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Wooley JC, Godzik A. Probing metagenomics by rapid cluster analysis of very large datasets. PLoS ONE. 2008;3(10):e3375. Epub 2008 Oct 10.