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Query: [D] COG5657 CAS/CSE protein involved in chromosome segregation, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDDIPTLLARTLNPTTSKSAEEALKVWELQDSSFALKLLNIVAEDTVDINIKLAASLYFKNYIKKHWDSEEGASIRISDEVAELIKREIINLMLKSTTIIQVQLGEVIGYIANFDFPDRWDTLLPDLISKLSAVDMNTNIAVLSTAHAIFKRWRPLFRSDALFLEIKYVLDRFCEPFLALFVQTNNLLRNGPQDAESLNSLFQVILLECKLFYDLNCQDIPEFFEDHMSEFMTAFLNYFTYTNPSLEGDEGETNVLIKVKASICEIVELYTLRYEEVFTMLYDFVNVTWTLLTTLTPDEKYDGLVGKAMAFLTSVIRIRKHAEFFQQDQVLQQFIELVVLPNICLRESDEELFEDDPLEYVRRDLEGSNSDSRARSAIVLVRGLLDHFDQKITSVVSTHINANLQQFSTNPSLEWNKKYVALQLFSAIAIKGQSTRLGVTSINLMVDVVAFFENNIKPDLLQPAGVIHPMVLAEDIKYVFTFRNQLNSQQLIDIFPTILRFLEMPSFVVYTYAAIALDQLLTVRHNHVHIFTSLLIAPHILPALNQLFLIVESASTPQKLAENDYLMKAVMRIIIMSQEAILPAASLLLQHLTKITEEVSKNPSNPKFNHYLFESIGALIRSLSKSGPQTVSQLENALLPVFQNVLIEDVTEFIPYVLQLLSQLVEASGNEPLPDFVVNLIQPCLSPALWDSKGNIPALVRLLRAMIFRGPQIFISNKFVEPVLGIFQKLISSKVNDHFGFDLLDRVFTVFNANILAPYINHIFFLLLSRLKNSRTERFVLRCTIFFFFVASEQTGTCGPDNLIQGVDAVQSGVFGQLMTSIILPQAQKLALPLDRKISALGLLRLLTCDLVLAPDAIYENLIIPLLTCILKLFEMPIEQAQTDADEELFMDEIDADSMSFQASFSRLATTGGKRVDPFPQITDLKQYCATEMNLANRNMGGRLSQIISTHLPGDGQSVLQSYGYVILast
1 -197.000[D] COG5657 CAS/CSE protein involved in chromosome segregation  ali  100  1MDDIPTLLARTLNPTTSKSAEEALKVWELQDSSFALKLLNIVAEDTVDINIKLAASLYFKNYIKKHWDSEEGASIRISDEVAELIKREIINLMLKSTTIIQVQLGEVIGYIANFDFPDRWDTLLPDLISKLSAVDMNTNIAVLSTAHAIFKRWRPLFRSDALFLEIKYVLDRFCEPFLALFVQTNNLLRNGPQDAESLNSLFQVILLECKLFYDLNCQDIPEFFEDHMSEFMTAFLNYFTYTNPSLEGDEGETNVLIKVKASICEIVELYTLRYEEVFTMLYDFVNVTWTLLTTLTPDEKYDGLVGKAMAFLTSVIRIRKHAEFFQQDQVLQQFIELVVLPNICLRESDEELFEDDPLEYVRRDLEGSNSDSRARSAIVLVRGLLDHFDQKITSVVSTHINANLQQFSTNPSLEWNKKYVALQLFSAIAIKGQSTRLGVTSINLMVDVVAFFENNIKPDLLQPAGVIHPMVLAEDIKYVFTFRNQLNSQQLIDIFPTILRFLEMPSFVVYTYAAIALDQLLTVRHNHVHIFTSLLIAPHILPALNQLFLIVESASTPQKLAENDYLMKAVMRIIIMSQEAILPAASLLLQHLTKITEEVSKNPSNPKFNHYLFESIGALIRSLSKSGPQTVSQLENALLPVFQNVLIEDVTEFIPYVLQLLSQLVEASGNEPLPDFVVNLIQPCLSPALWDSKGNIPALVRLLRAMIFRGPQIFISNKFVEPVLGIFQKLISSKVNDHFGFDLLDRVFTVFNANILAPYINHIFFLLLSRLKNSRTERFVLRCTIFFFFVASEQTGTCGPDNLIQGVDAVQSGVFGQLMTSIILPQAQKLALPLDRKISALGLLRLLTCDLVLAPDAIYENLIIPLLTCILKLFEMPIEQAQTDADEELFMDEIDADSMSFQASFSRLATTGGKRVDPFPQITDLKQYCATEMNLANRNMGGRLSQIISTHLPGDGQSVLQSYGYVI 967
2 -164.000[YU] KOG1992 Nuclear export receptor CSE1/CAS (importin beta superfamily)  ali follow..  37  8LQTLTEYLKKTLDPDIRRPAEKFLESVEGN-QNYPLLLLTLL-EKSQDNVIKVCASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGREDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKATIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFWEGNMETWMNNFHTLLTLDNKLQTDDEEEAGLLELLKSQICDNAALYAQKYDEEFRYLPRFVTAIWNLLVTTGQEVKYDLLVSNAIQFLASVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEEAFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNPSVNWKHKDAAIYLVTSLASKAQTQKHGITQANELVNLTEFFVNHILPDLKSANVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLINHLQAGSIVVHTYAAHALERLFTMRGNNATLFTAAEIAPFVEILLTNLFKALTLPGSSE----NEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMFEAICLSIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFIPYVFQVMSLLLETHKND-IPSSYMALFPHLLQPVLWERTGNIPALVRLLQAFLERGSNTIASADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQNSKTTKFIKSFLVFINLYCIKY----GALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKKICAVGITNLLTECPPMMDTE-YTKLWTPLLQSLIGLFELPEDDTIPDEEHFIDIED----TPGYQTAFSQLAFAGKKEHDPVGQMNNPKIHLAQSLHMLSTACPGRVPSMVSTSLNAEALQYLQGYLQA. 965
3 -132.000[YU] KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily)  ali follow..  13  3VDPVVYQLQRAVSQDAVKDAEGHLNNWKKE-PGFFGKLYSIFLDKQNDMSLRWIAIIQLRNSIDIIWRKNT--KMSLLPEERDFIRCNALLGSIKSENLLSIQNALVVSRIARLDYPTEWPSLFHDLLGKLQQGDYDVALRLLITLHHIIKAMAGN-RLLRSRQIFYKLAPELLTILQPILHSSLSSWMMKEIKDSTLLSYMQISRYTLKACRRLVVFGFQEFSERMLAFCAVHQRKLLSMLGTMLQSSRSPISLHYDFLGQISSHLSSYKEKFEESSKNFEKLVIMSLRVFILVIQEFCNTK--------SSHPETAQVLYNSFLVDNRINNLLDLLITKLLILKEEDFEEWTDSPQQWVLEQSTQDVEFNVRPCAEKLLKCFFDAYGDIIVSPFKDMIYSVFEC--PKTLTQAVQQDTLISSFGVGYTQLKSI----------FPFAKWLQEAAVPNMASINGISRVYRRRIAIFLSQWIEDSSSEQLLEVIYKLYCSFLNCNDAVVILTTIDAFKTVLD-----DWNFSENSFLSIKENLFVHVLSLFKAFESVD---ARTSILSLLGTLLARAGEHVAPMESTIASLLSQLWDGWKKEP-------LLRARVLAVMHQFVNAIKAKSFEFSTFLYTVIEYCVNPESPEHVIFEADAMELWSTFLMYIQKLPETFTLLIPHLLYHLSQATSTLPFVLMIVSSYQLLDNTVLMKD-YSFTIFEKLNDLLDDVKNETLQCKTVCLLIETTPMDMIYELNSSLLSRLLLSIATNDKHPQVLIEYLLVVSRISL----REPELILKVCQTKNI--NIAMLIGNWILLNDHINHSKDRKLNTLALSSLLRTNHPDVLAV-----LDSIMNLWFSVLSEVEEDANGDATIYYKNDDYSAVGYLDETSEEMTRRKQLLLKDPVHSV-NSRSFFISVFMFCRDANGGMFQNQYLSTVNPALLEQFQSML... 983
4 -125.000[O] COG5656 Importin, protein involved in nuclear import  ali follow..  15  4EQAILSCIEQTMVADIIKEAEQQLFEFQ-KQPGFTSFLLNIVSDDNFALNVRLSSAIYLKNKIHRSWDTKR--EDGIKADEKLSIKERLIETLVKNCNHIRPILTETINGILVGQEDWDLAPIIKNL---LSSGDASYIYPGLLLLFQLCKAHRWDMVGS--RDYIDSVIEELFPIVEGIASNIGSQTDYR---------SNEILYLILKSFKYACLNNLPQYFSQRIMSWVQLHLYLCSKPLPELDPADRSLDKRVKVNKWGFGNLNRFLQRYNKITKIVPIILREFFKDIEAWGNNSLWLSDSSLYFLISFLEKCVTIDQLYPLIEPHLQIIFENVIFPCLCANEQSIELLEDDQEEYTRRYFDINREGSTPDAASADFIFLIGSKRPEKLNNILPFINDIFTRFDANSSDMAFKEEGALRTLSNLFSFIDEPS----------VLENIFGHFIVPLLSQDK---YMFLVARSLETIALYSEEFDMNILSQLFELTYTNFNSNVLPVQIEAADAIKCLIVSNP-----QIHPAVSAHVPGMMEKLLKLSKIFEI-------DILSEVMEALVERFSDELSPFAKDLASNLVEQFLRIAQALVENPSETYEIQASGLLQTMTTMVMSMNKVPLIESLAPVVKFVVLHAQISFITEAVDLLDALTISSHYNQIAPPIWELLHDILDSFQTYAMDYFEAYSIFFETIVMTGFPQDQT--YVQPLLEILSAKLESEVDYDIEHVMQILMYFALS-----RDIPLFSKAIKVSTNDELGLDSKCIVKLGLANLFAKPIE---------TLQIMENEGFTINFFTNWFN--EKFYSVFAIKLQVLVILTLLKMPE---VPNSVSPLLNNLTNKLVELTLSLPKAIRNRDAVTEG-KSLEGDLTPEEEEEYFIECDDDMKETVLDQI-NVFQEVHTFFKNLQNEDAGKY-EKIINYLDESKRDSLQVILEFV 941
5 -61.000[YU] KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily)  ali follow..  13  10LEQVIQLLQHAHSTDVQRNVQVQLVQLN-EHQKFCCYLVYILMKEMIDATSRSLAGLLLKNNIRAKWNK-------YPQDVKFFVRTTCLKSIGDQEPLIRATVGIIVTTIVMEENMCDWPDLLDTLATVLMQPDELMQEGALGALQKVFEDSADRYESEFLRPIMPKLLVFYEHHAAKMRALAMNCVNCNDPIDFAIDQFLTSLFARHN-VQKQLCRSLTLLLDTHIEKMMPHLPNVIEYIIKKTQDHNES------IALEACEFWLSIAENSDICRTMVLPHLDKLIPVLLGSMRYSETDPALKANDEDSSVPDREEDIKPRF----------------HKSKQHGLGGLVESDDEEDEDDDDDGGGDWNIRRCSAASLDVLASIFGKDLLDKLFPLLKDTLM------NDNWLVKESGILALGAIAEGCMDG---------VVPHLGELIPFMLAMMFDKKPLVRSITCWTLSRYSSHIASDERQQFFKDVLANLLRCSLDGNKKVQEAACSAFATLEEEAG--------EQLIPFLGEILDQLVKAFQCYQAKNLLILYDAIGTLANSVGD--ALSHPVYVQMLMPPLMEKWERLSDEDK---ELFPLLECISAIVSAMGQSFLPYIQPVFTRCCSLIEKCVQQNQQHFIIVALDLLSGLAESLPEHMDPLVANSKLVELMLFCSLDVTDVRQSCFALLGDLTKACPERVLP--QSSNFIFFLAQNLDPSKISVNAIWALGELALKM-GPAMKQFIGPIIEPLIVVINSQQNMQ---RTLLENTAITIGRLGQCCGEELAPHISR---------FVRPCCYSLRNIKDNAEKESAFIGLCNMINMNPVGVLN-----DFIFWCDAIASWTVP----------------------------------------------DSLRVLFAGILQSFKQQVGDFNWNNFILQLPPPLRERLSAF.... 880
6 -49.800[U] COG5215 Karyopherin (importin) beta  ali follow..  10  3TAEFAQLLENSIDQNIRLTSETQLKKLNDNFLQFAGLSSQVLIDENTKLEGRILAALTLKNELVSKDSVKTQQFTQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIADIELPHGWPELMKIMVDNTGAEQPENVRASLLALGYMCESAD---------PQSQALVSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFI----------KNNMEREGERNYLMQVVCEATQAEDI-------------EVQAAAFGCLCKIMSLYYT---FMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTI--CEEEIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTR--QNEDPEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNIT------ADNWRNREAAVMAFGSIMDGPDKVQRT--------YYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIPQQHLPGVVQACLIGLQDHP--VATNCSWTIINLVEQLAEA----TPSPIYNFYPALVDGLIGAANRIDNEFN--ARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDLQSNILTVLAAVIRKSPSSVEPVADMLMGLFFRLLEKKDSAFIDDVFYAISALAASLGKG-FEKYLETFSPYLLKALNQVDSPVSITAVGFIADISNSLEEDFRRDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNI-GADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQ--DWVIDYIKRTRSGQLFSQATKDT................................................................................. 847
7 -49.700[YU] KOG1241 Karyopherin (importin) beta 1  ali follow..  11  6AMQLIAILEKTVSPDELLSAKNFLEQAASNLPEFLKALSEILVNTANSAVARMAAGLQLKNHLTSKWHQ-------FPSEIRELIKNNILAALGTENTRPS-CAAQCVAYVAVIELPNRWPMLIQTLVNKVVSEGSSERESALEAIGYICQDIRFGVMENQSNDVLTAIIHGM---------------RKVEPSNHVRLAATTALHNSLEFTKSNFEK------DMERNFIMEVVCEATQCQDS-------------QICVAALQCLVKIMTLYYQ---YMEPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEE--IDLAIESQEATDQGRAPQRVSKHYARGALQFLTPVLVEKLQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIE------SPNWRFRDAAVMTFGSVLNGLETN--------TLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTPETYALSPYFEYIITQLLETTDRSDGAQANLRCAAY-QALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINLQSLLCATLQSVLRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQ-FAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQVLSAFIALSIGNHFLPYLSMVLDMLRVASNTDANNFDMNEYINELRESILEAYTGIIQGLKGVDQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLAIGDLCTSFGPRLYPLLDDAIITQFLAEGKR............................................................................................... 857
8 -38.200[YU] COG5101 Importin beta-related nuclear transport receptor  ali follow..  10  13IALLDQVVSTFYQGSQQKQAQEILTKFQDNPDAW--QKADQILQFSTNPQSKFIALSILDKLITRKWKL-------LPNDHRIGIRNFVVGMIISTQKNLINKSDLTLVQILKQEWPQNWPEFIPELIGSSSSSVNENNMIVLKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCFQVLEQGSSSSLIVATLESLLRYLHITLKCLTEVSNLKIPQDNDLIKRQTVLFFQNTLDLKATYANANGNDQSFLQDLAMFLTTYLARNRALLESDESLRELLLNAHQYLIQLSKIEERELFKTTLDYWHNLVADLFYEVQRLPATEEICSQLRLVIIENM---RPEEVLVVENDEGEIVREFVKESDTIQLYKSEREVLVYLTHLNVIDTEEIMISKLARQID----GSEWSWHNINTLSWAIGSISGTMSEDTEKRFVVTVIKDLLDLTVKKR-------GKDNKAVVASDIMYVVGQYPRFLKWNFLRTVILKLFEFMHETHEGVQDMACDTFIKIVQKCKYHFVIQQPRESEPFIQTIIRDIQKTTADLQPQQVH----TFYKACGIIISEEVAERNRLLSDLMQLPNMAWDTIVEQSTANPTLLLDSETVKIIANII---------KTNVAVCTSMGADFYPQLGHIYYNMLQLYRAVSSMISAQVAAEGLIATKTPKVRGLR----TIKKEILKLVETYISKNLDDVVKVLVEPLLNAVLEDYMNNDARDAEVLNCMTTVVEKV-GHMIPQGVILILQSVFECTLDMINKDFTEY-HRVEFYKLLKVINEKSFAAFLEL-----PPAAFKLFVDAICWAFKH-NNRDVEVNGLQIALDLVKNIERMGNVPFANEFHKNYFFIFVSTFFVLTDSDHKSGFSKQALLLMKLISLVYDNKISVPLYQEAEVPQGTSNQVYLSQYLANMLSNAFPHLTSEQIASFLSAL-VVFKGTLRDFLVQI 1039
9 -35.200[YU] KOG2022 Nuclear transport receptor LGL2 (importin beta superfamily)  ali follow..  8  6IAHAKKLVYDSLSPSAIAATEKELQKAQRSQQGWNIG-LFMLQSKDVY--EQFFGALTLQMKINTQLET-------LSDKDLVQLFVQLLQKLLGLPALVERKVICTLASLTIKYELEKKEEASLKVIYCLFCNSSRNAQLTASYINELLLELSFSIYTKENEDALFNNVFRPCSNIIVSVLVFIFTNYSLDLSKEKNVAALEEALNCMIAISSYLAKASVSV-DEVSEKAMNCLADLLANYSNFITQPTIERLWTILTGPWGETHLQQELEDPDSGEENDYSFLNIVIGFAEAMLPQIIDHIQEEKSIRLLYILASLLSFPGYAIVEQIAFSVVEKAWWKMLLPSPEQWNSWPSSSRDSFNS----------RRDLGDLLESSYSIFGERLYAMYITTIENFFS----DGTGSPQSLEVSFYCLCCILEYDTNDSDTLDAW-----LTRLFETSFAIKASAFQ---NPQLLKTCSQLLSSCSCFLQPQYLNISLPVLFDALHISETSIQMTVSRSIHTLCTT---------ASHLLTEIDGFMAVVEELTPKLVYVPS--VLEKIYSSVGYVTQRIEELRISYLMRLLNCILAQLQPSLYPNLEIFENVSCLQSVAGVALSQSPIGESPIAEFQAKLISFLTHSESMQYSDVVGLICKIMIAGLNEVEPSPFSLPIVTTIQYFCDRFFMNNIDITVELYHFFSIILQKHPSFLETMY-TQLILNRAINLLGKPERLLAAGQFIISFITSEKSDFVNAIRSPLIAKILLGFGGNASRSSLPLLSDILGKLKALTQSLEEEGFPSRNVSNEIKRRFLTDLLKARIKDK............................................................................................................................................ 967
10 -33.300[U] KOG2081 Nuclear transport regulator  ali follow..  11  9VYQAISALFQGNNPKEQEKANKWLQDFQKSIYSW--TIADELLHQKRDLHANYFAAQTMRNKIQNSFSE-------LPPHTHESLRDSLITHIGQTDNVIVTQLSLAVADLA---LMASWREPINDLLVTLAPHQ-CAIWPLLEVLKVLPEEIDSRYLGANRREEVHKQLDASAECVLKFLCMCLQREDLDQQ---------RVWNAALRTYSAWLVIHAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCALLSCINTRQDGASDPESSFEAQLFGAVCMLETPYHLSVAHEDTDKTINYCRIFTSLCDALADAQKPHYSLKGLDLVLLCVGHFDYEVAEITFHLWYK--SEDLFQRNEDKLTVLFRPHIERLISALFRHFRRKVSDLIKGACFKQMFHILQAPETTWESTEAALFIMQNVAKNILPD-------------ENEVIPKVVEAILNMSEQTHIAVRYTAILLIGELCDWIEPESLEAVLNFLLYALQQKNG-LAPAAAIALTSICSA---------RQKMVCHISGLVEIARSLDSFQINND---VAIGLLKGISLILTRLPRELREIVGFQLQPLAQLVDSTGSTPQKGERTDAILNDAWQLISRVMDKYQS--LRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHHSCFLYVG--SILVDEFAKSSECIGGLLEMLQAFIEPNPDTLLQSSLITPIFQCALIACSLDHREASVMKFFINLLVWGRSELASQHGGALVMNLIQASVFQLHSYMLVDVAEVLHELKQVVGNERMQPFLAQALEALGYVTATQQQLDEFSSTVLRADTTKAISQALKTFTRLF........................................................................................................................ 913
11 -32.100[A] COG5181 U2 snRNP spliceosome subunit  ali follow..  8  455THKILVVIEPLLDYYARAEGREIISNLAKALAHMIATMRPDIDHVD---YVRNTTARAFSVVASA-----------------PALLPFLKAVCRSKKSQARHTGVRIIQQIALLSILPHLKNLVDCIGHGLEDEQQKVRIMTALSLSALAEAAT------------PYGIEAFDSVLKPLWSGVQRHRG-------------KSLAAFLKATGFIIPLMEPEYASHFTRRIMKILLREFNSPDE-------------EMKKIVLKVVSQCASTDGTPEYLRTDVLPEFFHCFWSRRMASDR-----------RSYKQVVETTVVLAQQVGSRQIVERVV----NFKDESEPY---------------------RKMTAETVDKVIGSLGSEIDERLEELLLDGVLFAFQEQSV---EEKVILTCFSTVVNALGTRCKPYLPQ---------IVSTILYRLNNKSANVREQAADLVSSITIVLKACGEEALMRKLGVVLYEYLGEEYPEVLGSILGAIKAIVS-------VVGMSSMQPPIRDLLPRLTPILRN----RHEKVQENTIDLVGKIADRGSEYVSAEWMRICFELIDML-----KAHKKSIRRAAVNTFGYISKAIGPQD----------VLATLLNNLKVQERQNRVCTTVAIAIVAETCMPF-------TVVPALMADYRTPEMNVQNGVLKSLAFMFEYIGEQARD--YVYAITPLLADALMDRDAVHTAASVIKHLSLGCVGLGVEDAMIHLLNILWPNILEESP-----------------HVINAVREGIDGIRNCIGVGPIMAYLVQGLFHPSRKVRNTYWTSYNSAYMVPYYPHVDDDQFNNYDMKTLHICI.................................................................................................... 1188
12 -17.400[BD] COG5218 Chromosome condensation complex Condensin, subunit G  ali follow..  10  35.TDILRALNIILTVKKGNSNADRVLRFKDPEIDIVQPILKHILRDAKDKTVRYRCCQIIARVVNC---------KEIDDDLYNTLKEKLLSRVLDRESIVRLEAVVALSRLQEDTGDEE-NDVRNILLFLLQNDPSSEVRRSVLTLPFILERARDV--DAANRKCVYARVLPKIGDFRYLSIKKRVRILKWGLNDRDESVEKAAADMLAYQWIENADNNLLELLEDVAVLAIKKFFDVRVDSLSQLEFPEQFWLELTAESSLLARTFNEICIE-LDKMPEVVQLTYYIERQYVSLRDKSSYDESCFIIEQLLYIGLSQDMVTNSLSTMALPDSLISLHIELLRKLCSSENDFCSTEVFEQGHSQNQTEEQGNSNAPELNKNDYEGEEITVSQKSPSPSLPPNELNEPEPDDMDGYKEAFNELRCLSYVQCLFENITSSLNENLY---MVDMLKTLIIPAVRSHDLPIREKGLECLSLVC-----LLNADLAFENVPLYLHCYEKGSVVLKCTAIRTLTDMLIQHGKAKFTEYED----------AISSILFEALGEFENAELQTLGAEAIAKLL--VILHYRD--ELFLKPLIIQYFEPNTVDNHA-----LRQVLGYFFPVYAFGAHENQWRIATIFCDALLSLLELDEDDVQLSIGHIAQQMLDWTDNEKLYERKTQTGDDYIALNHNVHLHLANMIFESLPN----------EGKERKFMISLLGKLKIPTDLPSSDYQRTKRKLETYESHTMDSTSLSILAKFERMLLQ.................................................................................................................................................................................................. 817
13 -17.300[OZ] COG5234 Beta-tubulin folding cofactor D  ali follow..  7  64LSKYVPNLASYLLKVKNIGKCNSITVI-CKIRGYKAVRVLF------PVGVQYIKELYLNESSNNTWHFH--TPFPLNSDDSLDVKKTIYTIYLENSGIDKEASCLVLSRLSRDDGLDLLLGFLHHCESSWFKRSIFYKIGCLFSLSSFLKI--------CPRNDCLQTVDVAFQFLNVAREDLVG--QENSALRKLLCKCYTRLGIVLPDSFFQLPDDSNEEVHIYLEVIVDFLLSSVS---------DIDSFVRWSAAKGLAKIISRLPWNLAE--QVIDAIIELMTENMFLNPIENTVNISITSPLVWHGAILFFAKLAGAGLIKYSKCLHILPLIEVGLSYEVRDASVWS-----FYHCYSKSAIEGLQTNLILCLLQTVLFDNEINVRRAATAALFEVIGRHASIPDGLSLISHINYVSVTDISNCYGDLCMKVAHFP---QFRSCVFQRLFTNLQHWDVKVQQLSAFSLRQLSI-----KYPKELSIYLPPILDYLSVGNADFIFGYTIGLASIIGGFLSISFPFDINRIHDLLSHIILGILKGIQQIFANDIRVDRAFFSEAFSVIIAAIDLQEETIIKDISDAYSVLVKFDDMEETLEVLLDYIRKCSTSKEARIVYIILQNLPNISFRYQKKICKLLQLHSIDYQAPVANALQNIIPFTYEKT-----------------ESIEEFVKELLQVCSNYLTDTRGDVIRKPAMKAISSLLVKDSSGKKLSEDIVWCCISYIIRQTFDKIDSLRGLAYQALEQIRVHYLIRRCEALTNIINRISFRNNPNMDGEVLNELNISLLEIPNLRLQAFYGITVFTADGFGSDLAVKCFEFYLSYVYQLEDSFKKSNSRYGKRDLLQLYIDILSSEDEIAR-----AYGCFTDFQNVKGMSKAIFIVQRRALTCKS--HALKYTANLLLNPIEKVRYQAADTLLYAKSIGLLTFLPNELNQKLLTL 1076
14 -16.000[S] COG5369 Uncharacterized conserved protein  ali follow..  8  10SSFFKENPKIFKDEHELLRYIVPFKKEYAIRNGAPKLLLNLFSLENLSMNEKYQVFVVLNSLMS--------DQDPFVQFLRHEDLLSVMQMISKRDSTPYGMLNITLKVFNTM------NQMFDLYTLPLKEQPSLDVLRISNLSSKILHRLILYNSKVGDSPRFCSALFQITNRALRLYSRRRFWNDCSILITNSLGTLNAYLKQHVKSYKQREKTRLESNGHVSPRDMDLDEIENVFEGNKDKVALFKSEIFGPNGDEYITQLFCLVRQFDPCIRLLSISCLVTL--------------------------------YKAGILSKNQTKEIQMIVTPILIRLFFESREA---------------------KQIAPRILAIIINENEIGFIDAAKYLLEYATKEEENEINF--LQSSAACECLLSLSRSVYILRTGL--------ADADVSEPLIKLLSDPDTRVKSTATSAICNLVLKFSPLREKFLTTNFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLKKI------GASKLVELCNDEDLG----VQEQMLQVLRNFTCQKEESVDFLLKM-MELLAKILLEKLESKNPI-----LIEPSIYILVHIAASDGELRDSIQTKLLLLVKEIMLQEAQRLKPEQMSTNVSSPESDSEMDLQEDDFDPFDIYEEDTYEPNSEILLAGIWLCINILWPKQCTSPSQEDKERASILLQMLQNHSSPD...................................................................................................................................................................................................................................... 713
15 -16.000[R] KOG1293 Proteins containing armadillo/beta-catenin-like repeat  ali follow..  8  10SSFFKENPKIFKDEHELLRYIVPFKKEYAIRNGAPKLLLNLFSLENLSMNEKYQVFVVLNSLMS--------DQDPFVQFLRHEDLLSVMQMISKRDSTPYGMLNITLKVFNTM------NQMFDLYTLPLKEQPSLDVLRISNLSSKILHRLILYNSKVGDSPRFCSALFQITNRALRLYSRRRFWNDCSILITNSLGTLNAYLKQHVKSYKQREKTRLESNGHVSPRDMDLDEIENVFEGNKDKVALFKSEIFGPNGDEYITQLFCLVRQFDPCIRLLSISCLVTL--------------------------------YKAGILSKNQTKEIQMIVTPILIRLFFESREA---------------------KQIAPRILAIIINENEIGFIDAAKYLLEYATKEEENEINF--LQSSAACECLLSLSRSVYILRTGL--------ADADVSEPLIKLLSDPDTRVKSTATSAICNLVLKFSPLREKFLTTNFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLKKI------GASKLVELCNDEDLG----VQEQMLQVLRNFTCQKEESVDFLLKM-MELLAKILLEKLESKNPI-----LIEPSIYILVHIAASDGELRDSIQTKLLLLVKEIMLQEAQRLKPEQMSTNVSSPESDSEMDLQEDDFDPFDIYEEDTYEPNSEILLAGIWLCINILWPKQCTSPSQEDKERASILLQMLQNHSSPD...................................................................................................................................................................................................................................... 713
16 -15.600[S] KOG0212 Uncharacterized conserved protein  ali follow..  10  2DNLLVRGLTHKL--DKRKATAYELER-----------VVKGYLENDETEKIRAVISQLANDFVY-------------SPARGPNATFGGLIGLAAVAIALGPKIDSYM------------ESILLPVLYCFNDSDSKIRYYACESMYNIGKVAK---------GEVFRYFNLIFDVLCKLFA-------------DTEITVKNGAELLDRLIKDIVMQQAATYMSSAEDI-------------------------------------------------------------------KNFKEGPVSSSIQDVPVMSTEQPRMHTFSLSELVPLLSERL----------------------------YVINPNTRMFLVSWIRLLDSIPDLEFISYLPFLLDGLMNYLSDPNES---IRIVTSNCLYDFLREIQKIAKVKYHILQRDEEPDFFDSMVRRNMSDAELKEISDYVESSLRDGSFILEAHIQIDYKRILEIIIDHLGSSVPLIQEKALKWLFEFIY--------IAPKDVLLQIPKVLENLLPLMSNDEN--------------------MRQSAKDLSQNLVILVSKIMDIEFSGSETNNKDNSLSVDFRSLIEVLQKLLSNDNEETRLCALEWVLLLQRRTGGKLINMHDPIFQTLLLQLSDP--------------------SDLVVSRTLELLAHIAISHKSVNLVP--LKSLLQMFAE--DRKFLNSRGNLIIRQLCNYIEGE-------RVYTSFAGILETEENLELASIMVEVLNNNLFTAPELYDLRKKLKQSAP-KLQNIFTTLYTAWCHN----------SIAVFSLCLLSQNYEHAANLLSVFAEIEFNIDMLIQL-------------------------------------------DKLVQLIESPVFTYMRLQLLEPEKYPYLHKALYGILQSSAFRTLRDRLQCS 705
17 -15.500[S] KOG2149 Uncharacterized conserved protein  ali follow..  10  68LLELKNRTGHP-NAKVRKDALHGIKDLLKHHPATTHKLRELITDD--DKLVRDDFYTLLTGIFLACKEDINKGLMV------SSLMPYIFTAMTKSSIEVRLMAFKFFRLVLEF-YSPYAEKILENYKDVIHNQDKKKLKVVLLGLADCLSLLPCDQSECVRFAHVSGILKEIVAVLINCFQDFLPLIHASQRINKESFDCIRHILRSIGYAIKFSIRRHTQRHTKWLPSLDRDIASMLSKKLLGSFPLNHENNFSVENNGVLTEIFLEVSEWSHLPCDLSNRFLEFIENALLGKITRSN-------------------------SLDKTLLALLPFV---PKLLLRVDRDRRDNLMQAFTITFNNCKPESSLKLACISVVKDLIIPNGDTVNNYQRAWVNKLPSLLNQLGDKHHVSTKVVLQLLLDLARVGCLNASPTFEE----EIRSFFIPFHGEGEVPGGPFVSL-VQEVALCFLYYFII---DNFSSPMLKAIVSCCLYEQLEPAV-LYRIVEILQTAYRGGYIQ---------ITDHFSFFITLIECDERKANCGTFKTLTNLVCSYLSEMGDS-----SLVLQILEKVFVEQIILKPALDNGCAILRMICALDSKPTRLSEISVTTLSEFLPGYL---------------IDIVNCIPEDKERSYLYMQTCLYYLLPCYFLFDRSSKLTEQVLKRMRSMVSENVKALESVQDRESGRDSLNLI-----------CIVSVILLMHNDVKVRKIIKSEIDLILQNVYTLQSSRST----------------------------------------SLTVEGKHMMKIAAERSIASNSLLA.......................................................................................................................... 863
18 -15.400[S] KOG1949 Uncharacterized conserved protein  ali follow..  8  78IQDFMFGIHLPRRSPVHSKVREVLSYFHHQKQGVEEMLYRLYKPKARNSEVRSNAALLFVEAFP----RDPNLHAIEMDSKIQKQFEELYSLLEDPYPMVRSTGILGVCKITSKYWPTILIDLLKKVTGELAFDTSSA-----DVRCSVFKCLPMILDNKLSHPLLEQLLPALRYSL-----------------HDNSEKVRVAFVDMLLKIKAVRAAKFWKICP------MEHILVRLETDSRPVSR----------------RLVSLIFNSFLPVNQPEEVWCERCVTLVQM------------------AAARRFYQYAHEHTACTNIAKLIHVIRHCLNACIQRAVREPPEDEEEEDGREKENVTVLDKTLSVND----------VACMAGLLEIIVILWKSIDRSMENNKEAKLYTINKFASVLPEYLKVFKDDRCKIPLFMLMSFMPASAVPPFSCG-----------VISTLRSREEGAVDKSYCTLLDCLCSWGQVGHILVDNWLPTEHAQAKSNTASKGRVQIHDTRPVKPELALVYIEYLLTHPKNRECLLSANHLLKALETSKADLESLLQTPGGKPRGFSEAAAPRAFG----------LHCRLSIHLQHYLSMLEDTGFWLESKILSFIQDQEEDYLKLHRVIYQQIIQTYLTVCKD--------------VVMVGLGDHQFQMQLLQRSLGIMQTVKGFFYVSLLLDILKEITGSSLIQKTDSDEEVAMLLDTV--------QKVFQKMLECIARSFRKQPEEGLRVSDVEELTPPEHLSDLPPFSRCLIGII--IKSSNVVRSFLDELKACVAS--NDIEGIVCLTAAVHIILV-------NAGKHKSSKVREVAATVHRKLKTFMEITLEEDS.............................................................................. 869
19 -14.300[S] COG5543 Uncharacterized conserved protein  ali follow..  9  385MQDFFIRLRASCTMRSRHSDKVALSGLLDRAMQFLTSFISVCKKHLYPTC-QVLVSLSFLDTLISFGLDDNVESSSIREAQDRDLSRLMIDRLKDPYDDIRNLCLKILLSYKSLP-DSDAYFLFNHGLELLNAVRSHECDGGAKTI-YLCNHFMEKSVPGSVLANTKVILNRLKSNI-----EHAKTSLLEAAVNCPLQGYLIQLTYIFQSLSPTIVKNDNESWKNIVMELIKASETIWGLIKDVLCDDSPEGNL-WRSLKETSSLLTVLLTKCLSTPFTLNYYGELMMTWLWEIRHRGAFTSVYPCFIEYCSFLFECNKHEISELPDPWLHKNLSVIQEKSSFITRRSTAILVAGKDK-VEQKNIAGQFDLPQVHAMNTLKTIFTE--HRLSSVSVEYLEPAIASIEGFSHELWPIRNCSVMLFTALINRAFGSKKPKDAVNKGLSTKMFFSKFLLRELEVSVASLSSNDQPSTGLYAQPYGNENEWTGLSQFEPLIFKCTASRICKVREIASLSLTCLLDCSK--------------MTTFIVSQLKGVAGLQQNEIHGKLLTIRAVLSCFFSKLTLQVQEFYEVVPLAFINCFLEFTSSKTSFYAKKLFLEVLNSYFMSNTDSNAKRLQQLRRMTMDYCKRMLLDRKANVTNVFNTAATIFLENLKEFSVYCDAHSIGFLVSKLLHYEFYEVQLTTLRSIVDSPRKKIIVNNPE-----ILQALIKLTPRNQWSQVRALALS-LLSDSLNSTSYRLLGISCSDMVSNILSNECLPIKESFIVLLGSCIKQLKT--------------ENFLEYKVTFAKWVEILLSYSNEYSSRKAALDSIIHFDLFNAESTAEAFSFEFYILYLLLGDFLNDDDEEIRSLAAN................................................................................ 1339
20 -14.200[YU] KOG4541 Nuclear transport receptor exportin 4 (importin beta superfamily)  ali follow..  8  1....................................................................................MSLTTLHALSNQEDRLCDRFLEVSENILSWNFPISWKDLLDEFFILF-RHDETLCTKSMNCLIQLASLTGDCMPVADQEASTKYVRMLIINRLFLYRPLTSIMRQEPELRARFFGFLRDYTIHLTNQAMQKAIGEAEHEDHTSLALIYDAIVVLLRGRTCFSSEEEADAVDNELVKWPTLMIVNAFVSNLLAPPKGTRPVAKDEDDGDEDSEDRTLFMDLFNPLGAMICYSVGEFMENMATNLHTSLAEFTAMATTGSTGDMSRRLPMWQED-LANSIVGEEIDGACHVSGDVFDYTQKLFHTGRKFDETKKAQYLQMCIEQPTQDRAQYALEVDPFIIVMGELFAWASIEHDVFANASREM-LRRFLNAASSSVDCDKWNDYQGVSSENLPVMPQ--SKEFSAILVRFVIKKVLAVLVGSEEKLCQDAIDCLLSLVES-------------HASDIASSPELFEYLNSLDIARLPNRANLMKALVLIGAAANDQELQEMFKLILVPLSERFVSACDQPTRTDIDSQIVDYLQCFDGVAKASQSHSAPVLFKFLYAIIDKCVGNQNELVVSNILQLILDVTTKVSIYIDNEDESNALYASLLQIVEEKATDLALFIDILSNVLSKDFLTLGGENSLEMLLTIMDRVLQMPEVALKFFRLILYLVEFSPESLADQLMSSLCQCIRLGMTGQFGMEITSTSLESLTEVVLHFGSPANKGRCTQNLAFLFKE-MLPTVFETCLSNTCENSIYAESCSALYALIELFSKKSNQQARQVLEAAFTELMEVNPEPGNRRGRVQ...................................................................................... 910
21 -14.200[BD] COG5098 Chromosome condensation complex Condensin, subunit D2  ali follow..  9  275LKEISTRVFNAKDTTGPKAISNFLIKLSELSPGIMLRQMNLVITNNSSITLRCSVVEACGNIVAELAQDPQTMEH--YKQQIAVLIELLEERFQDSNPYVRTKAIQGCSKICDLS--KSKAKFTSLAVRSLQDRSSLVRRNSVKLLSKLLLKFKAIHGSQLRLSEWEEYLKGSESQLNSTLKKVESQETLNDTIERSLIEEEVEQDEGQCRTELEGSFN--------------------SAELSRIENEVENINATNTSVLMKLKLMIVYYKDAISFIKEIHKSIELISNLLFSKNRNEVLESMDFLVLADAFDIELS---------EFGIKKMLHLVWMK--SISVHLIECYKQ----FLTAPDSCNMQEKAAHIAKNLI-NLSIGASIADLASLEQLLGMMYEQKLIDQH-----------VINILWAIYNSASKASMQKE---------QNVNNRDSEKGFSKEQIHGSIIILGMLSLADNEIALKGLESLLNIGLGAVGLKDLTLCRYSCLALERMVPKRSTIITKAINQELEDVAVKKLYAI--IINYTKDNEYYPMCEQALSALFTISSKPDILATDLIREKTMMTFGKPEEEDSILSLEQSSRV--VSLSQLLFIVGQVAIKTLVYLEKCEAEFKKRKIEAETRN---------GKVKNQGADVTNTTQDNGGDKELEMIGGTNEDDFTDAIQFVKENELLFGEKSILGKPIVEEIVSNSSRFSDPMLQRTATLCLEKLMCLS------SKYCEKSLPLLITVMEKSPDPTIRSNAVLGLGDMAVC----------------------FNNLVDENTDYLYRRLHDENQRTCLMTVTFLILAG------VKVKGQLGEMAKCLD---------------------------------------------NPDQGISDMCRLFFTELASKDNAIYNGFIDIFSNLSSDDLLGK........ 1104
22 -13.100[U] COG5096 Vesicle coat complex, various subunits  ali follow..  11  17VDALKTSLESK-NDYVKISAMKTILRVVINGDSLPSILMHVIVMPSRNKELKKLLYYYWEVCPKY-------NNDGTMKQEMILACNSFRNDLQHPNEFIR---GATLRFLCKLKEPELLDPLIPTVRQCLEHRHAYVRKNAILAVFSIYQVS-----------------NHLIPDAASLAEDFLAAESEGTCKRNALIVLFTIDPEKAKAWLLANFEQIPSLNASSLLVIIEFIRKVVLTKADGLEKLRFQSLLVSLTATNNSSVVFEAATSVINVFPDAESLKLAASRLLALADREAD-------------------------------NNAKLIMLDRISQLAARDKSILEDLITDVIPFLSS---DFDVCEKAISIIMGLVS---SRNVEDILNHFQKELTKSNGETEKDDGRRRALTKAIHSCAINF-------------------------------------------------------PHTAATAIQYLLSHISDFQSKSASSVLSFIKEVMEKFPDLR------------SSNITKLLLSLKELRAGK-------IFRGVIWIAGEYCLTEDD-----IRVAWKSIRASLGEVPILASEEQLLKDVSNVPEDDLLIDISAPASTSRKVL........................................................................................................................................................................................................................................................................................................................................ 514
23 -12.900[U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4, beta subunit  ali follow..  12  15IFELKAELNNE-KKEKRKEAVKKVIAAMTDVSSLFPDVVNCMQTDNLE--LKKLVYLYLMNSFVKDCEDPNPLIRALADKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDIN-AQ--QGFLDSLRDLIADSNPMVVANAVAALSEISES--------HPNSNLLDLNPQNINKLLTALNECTE-----------------GQIFILDCLSNYNPKD-----DREAQSICERVTPRLSHANS-------------AVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPE---------------------------------VQYVALRNILIVQKRPEILKQEIKVFFVKYNDPI---YVKLEKLDIMIRLASQANAQVLAELKEYATEVDVDFVRK----------AVRAIGRCAIKV-------------------------------------------------------EQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKY------------ESIIATLCENLDSLDEPD-------ARAAMIWIVGEYAERIDN-ADELLESFLEGFHDESTQVQ--------LTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLST................................................................................................................................................................................................................................................................................................................ 532
24 -12.800[U] COG5240 Vesicle coat complex COPI, gamma subunit  ali follow..  9  68..GITKLFQHK-DPSLRQFVYIIIKELSVVAEDVIMITSSIMKDTATGNAIRSLIRVIDANTVP-------------------AIERILTTGIVDPISAVASAALVSAYHLYPVA-KDIVSRWNNEVQDAVTSHNVGRKVASSPFFTSTLGY------TPNASGISQYHALGLLYRIRRHDSIAMNKLLQLLVSNLGTVSNSHAFVMLIRYISSLMDQN-----TQFRDQMVPFLHGWLKSKGDMV----------------NLEVARNMVRLKNISDDDLQPVVSVLKIFLSS--------------------------------HRSATRFSAIRTLNELAMTRPHLVHSCNLNIESLITDV-----NRSIATYAITTLLKTGNDESDRLMKQIVTFMSDISDNF----------KIIVVDAIRSLCLKF-------------------------------------------------------PRKQDSMLTFLSNILCDEGYEFKRAAVDAISDMIKYIPESK------------ERALAELCEFIEDCEYPKIAVRILSILRFIRYIYNRIMLENAIVRSAAVSALTKFGLNAEDKF--------VQRSVKVILTRCLEDADDEVRDRAAFSVKALE.................................................................................................................................................................................................................................................................................................................................... 558
25 -12.600[U] KOG2180 Late Golgi protein sorting complex, subunit Vps53  ali follow..  8  48VDYINQLFP---NEQSLAGIDETIQKMQCEVSLIDDNIRSVVRGQTNTGQDGQLALCEAQKVISSLFSHIIDVKTRAERTEEMV--KEITRDIKQ--DCAKRNLTAAITTLNHL---HMLVGGIESLNKLIERRSYGEILNPLQAITEVFQQFSDIEEIKNLSQSVDKIQVTLAQQITEDFKEAFSAKPSSQNQHRLGLNQLADACKVMSVLDPKVKKELLKWFIAQQLEEYTHLFHENQDIAWLDKIDKRYAWLKRHLLDFEDKYGPVFPLDWEVSERITVEFCRQTREQLAQIMAKRTNEIDVRLLLFAINKTQ------------AFEQLLSKRFTGVTLGAQPTDKARVLAEPTTTDGAVGLTVFHDQIGQCFKPHLDIYIRSIDRNLSELMDKFVEMSREPYKFAEAKTTVYPSSGFVFYKKCMVQCNQLSNEQPMYDLALVFKKYLREYASKVLEGSTPKLVPATTSSSIGKSVSLLTRDMQNLSTAAGQVFHNFLKEGTQRFARDDLVRICCVLT---------TGEYCLETVQQLEDKLKEKVTSVSKIDMSEEKDVFHRIISNCIQLLVQDLEAGCEASLQAMAKVWQHINNVGDQSAFISSLCGNFKQTVPTIRDTLASSRKYFTQFCHRFVAAFIPK----FINVLYRCKLTLSDGSNNVLGCEQLLLDTHSLKTALLELPSVGSSVNRKAPTSYTKV----------VVKDMTRAEMIIKVVMTPVQPPAHFTQQVLKLLPDITIAEYQKILD--MKAVKRVDQLQLIDLF........................................................................................................................................................................................ 793
26 -12.400[TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family  ali follow..  9  535FCALLKNPDIISSSVKQSLLLDGFFRWKESMLSLREFIMKALASTS---CLRVVAAKVLPIFIKGPNNLDIVE-----HKESKALIFNTLKILAVENTAILETVILSWISLSRVVEEEELHFVLLEVISSVINSGIFYQGIGLSALQQIASTRHISVWQSPYWPTVSVAIPNIASLFAQLMNISEGDFLIRTQAYTLPFLVLTKNKALIVRIAELSQSDVATLCLTNMH---KILASLLTTDHPNLEES-------------VMLLLSLATSDFEDLTSLLRSDPISITVELLQLYQNDVPHEKIENALRKVAMIVSQVVNDEDLSNKELLYDFFNNHILGILAEFSNILN------------DLKGKTSINEKIKTIVGIEKMLSLCGGAVKLGLPQILSNLQSAFQNEH-----LRFYAIKAWFSLILATKEPEYS--------SIAGLSLVILPPLFPYLEPQEAELVIQIFDFISKEIFCSLQNEDFYSELQSIIKCLTNENEPVCYLGLQKLELFFQAKVDEHDTLNLDISNEVLDQLLRCLLDCCVKYASTNMQISY-LAAKNLGELFENGEESLKFILDFMQSQLIPAFLVTTDTKAQGFLAYALQEFLKLG-TVVTEHWMSLPDLSKRVLIPFLTSKYHLTPIPKIDIRYPIMQLFSLKLMEYAHSQNAEKIFGICSKVVKDQEVNIPCFLLPFLVLNVILTESELEVNKVIEEFQLVINQPGPDGLNSVGFVDVFFKIVDYLN-SKVESFLSRFPSKTLGI-VSLNCGFHARALFYWYRVLQEIYAGIDDPDEIEAVSLNFHDYSFDQQLLLH-SGTWDSALSCYEIIIQ-IGLLNMLQSGHYESLVLSLDSFIINDNHEYSKMLNLGIEASRSLSIDSLKKCLSKSNLESFEAKLGSIFYQYLRKDSFAELTERLQPLYVDAATAIANTGAHSAYDCYDILSKLHAINDFSRIAET. 1612
27 -12.300[R] KOG1877 Putative transmembrane protein cmp44E  ali follow..  7  1..................................MSAVSGVISRQVLPVALRARSR--YKKLIAEIFPRNQEEGINDRKIGK------LCEYAAKNAVRMPK-----FFQISDS--------LEHRCYKELRNENFHSAKIAMCIYRRLLVTCKEQ-------------IPLFSSGFLRTVQALLDQTRQDEMQIVGC----------------------------------QSLFEFVINQLCQLGLEGGDDDRSRSLRAAGLQALSAM-----------------------------------------------IWLMGEYSHIPSEFDNVLLGFRVPIYSDLLSFIEINWFVVSNNRQSEKHSVGDKVVSAVLENYGHPKILTNANDSGRKWVDEVLKNEGHVA------YEDSLINVPSWRTVVND-------------KGQRTHFLLSMLIKHLDHKS-------------------VLKHPSMQLNILEVTSSLSETAKVEHSATIVSAISDIMR----------------HLRKCMHSSLD--EANLGTDAANCIRMVSVAVDKCLVQLTKKA-FPEALFHQLLQAMVHPDHKTRIGAHRIFSVVLVPTSVCPRPSSTTTDLKKGMGLPRSLSRTASVFSSSAALFEKLKKDKFS-QNGMPEEERGSSTGEILDRLKSSYRQAYSTWNQPLTSVVDNSVDLLNSELVHPCNLLCVKKLTRRVVHFLLTLNGTLEFYDVVHIRLSSHQIGLLLSSIWAQSIS--PANTPDNYEAIANTYSLVLLFSRVKNSSHDALIRSFQ------MALSLRDISLMEGGPLPPSRRRSLFTLAASMVLFSSKAFNLFSLADFTKVTLQGPRLDPFLNLVDDHKLKAVNSDQLKVAYGCEKDDASALDTLSNIALSTEHSRGTLVYE---IVKSLEDMCNSEMDKMREQLLTEFMPDDACPLGT..... 768
28 -11.900[TW] KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins  ali follow..  8  353LERAVSMLEAD-PPSRISAAATFIQHECFQKSRGILKLLQLLKVQN---DVQRAVCGALRNLVFE------------DNDNKLEVAERLLQVLKQTRDETKKQITDHTVNLRSRN-----PSTLGGQGGRITRSGVRDQPDQHGLLWNLSSNDKLKNL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------MITEALLTLTENIIIPFSGWPEGDYP------------KANGLLDFDIFYNVTGCLRNMSSAGADGLIDSLVHYVRGTIADYQPDD----KATENCVCILHNLSYQLEAELPEKYSQNIYIQNRNIQTDNNKSIGCFGSRSRKVKEQYQDVPMPEEKSNPKGVEWLSIVIRMYLSLIKSVRNYTQEASLGALQNLTAGSGPMPTSVAQTVVQK--ESGLQHTRKMLHVGDPSVKKTAISLLRNLSRN--LSLQNEIAKET------LPDLVSIIPDTVPSTDLLIETTASACYTLNNIIQNSYQNARDLLNT-IQKIMAISAGDAYASNKASKAASVLLYSLWAHTELHHAY.................................................................................................................................................................................................................................................................................................. 857
29 -11.800[U] KOG1062 Vesicle coat complex AP-1, gamma subunit  ali follow..  11  34CADIRALINED-DPHDRHRNLAKLPGFPEKRIGYLGLMLLLDERQEV--------LMLVTNSLKQDLNHSNQYVVGLAAEMARDLAPEVERLIQFRDPNIRKKAALCSTRIIRKV-PDLAENFVNAAASLLKEKHHGVLITGVQLCYELCTI-----------EALEYFRTKCTEGLIKTLRDITNSAYQPEYD-----------------------------VAGITDPFLHILLRLLRVLGQGDADASDL----------MTDILAQVATKTESNKNAGNAVLYECVETIMAIEDTNSLRVLAINILGRFLSNR-----------DNNIRYVALNMLMKAITFDDQAVQRHRVTILECVKDP-----DASIRKRALELVTLLVNENNTQLTKELIDYLEISDEDF----------KEDLSAKICFIVEKFSPEKL--------------------------------------------------------YIDQMLKVLCEAGKFVKDDVWHALIVVISNASELH------------GYTVRALYKSVLTYSE------QETLVRVAVWCIGEYGDLLVNNVGMLSDAVDVIEDAITRHNSDSTTKAMALVALLKLSSR--------FPSISERIKDIIVKQKGSLLLEMQQRAIEYNSIV............................................................................................................................................................................................................................................................................................................... 576
30 -11.800[U] KOG1058 Vesicle coat complex COPI, beta subunit  ali follow..  10  23EAQLKEKFEKG-GDKERIEALKKLIYMKTSQSMLMYVIRFCLPSNEHT--LKKVLLIFWECVPK--------------TDSNGKLLHEMIKDLQHPNEFVR---GSTLRFLCKLREPELLEPLMPAIRACLEHRHSYVRRNAVCAIFTIYKNF-------------EFLIPDAPELVTEYLEQ-----------EQDASCKRNAFMMLLHVDQARALDYLSGCIDGSFGDILQL------------------------------VIVELIYKVCHNNPNEASRFIRCVYNLLQSSSPAVRY--------------EAAGTLVTLSNVPAAVKAAASAYIDLIVKESDNNVKL-SSNEKILQGLVMDSSPGLEVRKKTLSLALDLVS--SRNVEDMVMFLKKEINKTATESNDENGKYRQELVKTLHAATIKF-------------------------------------------------------PDVASTIVPVLMEFLSDTNEKASSYVLQFVREAVHKLPN------------LKNAILGALREGIPFIQSPTIFMSALWILDVLKLVKNSLGELPLVDSELSGQEEQKPEEQQPEQQQKQVTADGTYATQTALSSTVTTSKKNEKPPLRRFLLD....................................................................................................................................................................................................................................................................................................................................... 548
31 -11.500[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  9  23IQKLCDRVASSTLLDDRRNAVRALKSLSKKYRQAMEHLIHVLQTDRSDSEIIGYALDILYNIISNEEEEEVEENSTRQSEQQENV-TLLLSLLEEFDFHVRWPGVKLLTSLLKQL-----PMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQKI---------AFENAFERLLDIISE---------EGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSY---IQRMKPWFEVGDENSGWSAQKVTNLHLMLQLV--------------------------RVLVSPTNPPGATSSCQKAMFQCGLLQQLCTILMATGVPADILTETINTVSEVIRGCQVNQDYFAS-----LMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTLLPSTIDAFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGSKIQTRVGLLMLLCTWLSNCPIAVNSANVPFLTGQIAENLGEEEQLVQGLCALLLGISIYFNDNSLESYMKEKLKQLIENFIEKLGFISKHELYSRASQKPQPNFPSPEYMI--FDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEE---------LRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQ---------------LNSQSVEITKLQTEKQELLQK----------TEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEE--DELESGDQEDEDDESEDPGKDL.... 959
32 -11.400[U] KOG4224 Armadillo repeat protein VAC8 required for vacuole fusion, inheritance and cytosol-to-vacuole protein targeting  ali follow..  10  8CEKSKDEQYEPLLADREREAVADLLSFLEDRNEPLRALTILAYSDNLD--LQRSAALAFAE---------------ITEKDVREVDREVLFLLQSPDAEIQRAASVALGNLAVNA------NGLDLLIRQMMSPHVEVQCNAVGCITNLATLDENKSKIAHS---LGPLTRLAKSKDIRVQRNATGALLNMTHSYENRQQLVSA---------------------------IPVLVSLLPSSDT-------------DVQYYCTTSISNI-------------------------------------------AVDAVHRKRLAQSEPKLVRSLIQLM----------------------------DTSSPKVQCQAALALRNLASDERYQIEIVQSNALPSLLRLLRSSYLP---LILASVACIRNISIH-PLNESPIIDAGFLRPLVDLLSC-------TENEEIQCHAVSTLRNLAASSERNKRAIIEANAIQKLRCLILDAPVSVQSEMTACLAVLALSDEFKSYLLNFG--------ICNVLIPLTDSMSIEVQGNSAAALGNLSSRFIECWDSPAGGIHGYLVRFL---------SSEDSTFAHIAAWTIVQLLEAGVPRLTAFIQSS---DIIELLNDIVARDANNGEYEDGEGDVIL.............................................................................................................................................................................................................................................................................................................. 535
33 -11.400[U] KOG0166 Karyopherin (importin) alpha  ali follow..  9  29.........................................................................................................................................................................................................................................................................................................................................................EEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQISNMEMAPGVITSDMIEMIFSKSP------EQQLSATQKFRKLLSKEP--NPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKLSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSD-----PNDKIQAVIDAGVCRRLVELLMHVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVALNGLENILAKRNGTGINPYCALIEEA-IEFLQSHENQEIYQKAFDLI.................................................................................................................................................................................... 500
34 -11.200[O] KOG2062 26S proteasome regulatory complex, subunit RPN2/PSMD1  ali follow..  8  2.............TMVYSDNTSIITSAGG--------LMALLDEQ--ERELQVHALLKIYEFIDQLWPEISDDVTKIEVPERELVVSKVYYYLGEYDEALLFALSDYKETLIADPLDERLSGVVEGIFQKCYAKNEWRHVLGIAIEAHRLDIIEYILNADKETDLKPYVLERLLRLLLSSFLTETEPDYFS----------------VGKCVVHLNDASVAAKLLMKLSSQNDDKSLLTAYQLAFDLEDSAPQEFLNSVMDLLPSPSVANSEEDANADSKKEDSSPCGYIIRILSGEQTVKYDREFLYAHNNTDMLILNRTKDSLEARNSVFHNAVTFANAFMNFGTSSDSFFRDN-LSWLSKANN-----WSKFTATAALGVIHRGYYNQAMNILRPYLPE-----EDAPSSSTYSEGGAFYAMGLIHANHGRG----------------VTEYLREQLKHTEDEIVQYGLLLGIGLTGM-------SRDETLYESVKTILFNDNAVAGSAAGISMGLIMLGTASS-----------------AAIDEMLQYAHETQHEKIIRGLGIGIALIVYGRQQEADGIIKELN------------NDLDPTLRYAGMFATALAYCGTSNS---------KIVRDVLHISVSDVNDDVRRAAVCALGFICFKDPN---------ALISTVELLVDSYNPHVRYGSAIALGIACANSGS-------NAALDLLSRLVEDATDFVRQGAMIAQAMILTQHNDQLNSKVSGIRKHFEQVINEKHEDALAKLGATLAQGIIDAGGRNVTIALQTATGSLKLSAIVGLTV-YWFPLTHFMSLSFSPTA-LIGLDKNLNAPKFSFTAKTVQKVETAVLSTTVKAQARAKRAEREKKKTTEEKEATPMEMDEEKSQDISINGNSKKEEPKSETLENFTRVVPAQLPYISFNLNGRYYPLMLIDRESDKAPDL....... 930
35 -11.200[O] COG5116 26S proteasome regulatory complex component  ali follow..  8  2.............TMVYSDNTSIITSAGG--------LMALLDEQ--ERELQVHALLKIYEFIDQLWPEISDDVTKIEVPERELVVSKVYYYLGEYDEALLFALSDYKETLIADPLDERLSGVVEGIFQKCYAKNEWRHVLGIAIEAHRLDIIEYILNADKETDLKPYVLERLLRLLLSSFLTETEPDYFS----------------VGKCVVHLNDASVAAKLLMKLSSQNDDKSLLTAYQLAFDLEDSAPQEFLNSVMDLLPSPSVANSEEDANADSKKEDSSPCGYIIRILSGEQTVKYDREFLYAHNNTDMLILNRTKDSLEARNSVFHNAVTFANAFMNFGTSSDSFFRDN-LSWLSKANN-----WSKFTATAALGVIHRGYYNQAMNILRPYLPE-----EDAPSSSTYSEGGAFYAMGLIHANHGRG----------------VTEYLREQLKHTEDEIVQYGLLLGIGLTGM-------SRDETLYESVKTILFNDNAVAGSAAGISMGLIMLGTASS-----------------AAIDEMLQYAHETQHEKIIRGLGIGIALIVYGRQQEADGIIKELN------------NDLDPTLRYAGMFATALAYCGTSNS---------KIVRDVLHISVSDVNDDVRRAAVCALGFICFKDPN---------ALISTVELLVDSYNPHVRYGSAIALGIACANSGS-------NAALDLLSRLVEDATDFVRQGAMIAQAMILTQHNDQLNSKVSGIRKHFEQVINEKHEDALAKLGATLAQGIIDAGGRNVTIALQTATGSLKLSAIVGLTV-YWFPLTHFMSLSFSPTA-LIGLDKNLNAPKFSFTAKTVQKVETAVLSTTVKAQARAKRAEREKKKTTEEKEATPMEMDEEKSQDISINGNSKKEEPKSETLENFTRVVPAQLPYISFNLNGRYYPLMLIDRESDKAPDL....... 930
36 -11.200[U] KOG1077 Vesicle coat complex AP-2, alpha subunit  ali follow..  10  28LANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDAVNLLSSNKY--SEKQIGYLFISVLVNT------------NSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAE---SFSNEIPKLLVSGDTMDVQSAALCLLRLFRSSPDIIPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKR--NPDEYKGCVNLAVSRLSRIVTASYTDLQDYYYFVPAPWLSVLLRLLQNYNPVTEEAGVRARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNR-----------ETNLRYLALESMCHLATSEFSHEEVKKH--QEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNEEIVQEMLNYLETA----------DYSIREEMVLKVAILAEKYATDYT--------------------------------------------------------YVDVILNLIRIAGDYVSEEVWYRVIQIVINREEVQ------------GYAAKTVFEALQA------PACHENMVKVGGYILGEFGNLIAGDSRSAPLVQFKLLHSKYHL-CSPMTRALLLSTYIKFINLFPEIRTNIQDVFR------QHSNLRSADAELQQRASEYLQLS............................................................................................................................................................................................................................................................................................................... 579
37 -10.900[T] KOG4500 Rho/Rac GTPase guanine nucleotide exchange factor smgGDS/Vimar  ali follow..  10  2...............................ATEIDDLIEKLKTTSVSPANTTNLLCEISATKDP------------KLFDKHELAECFLGLTKCDDTNVRKEAAKCIAEITKSE-----RNIIAAFLECLSDGSMELPIQICRALGNICYLNDEARDLILELEGDAVLLRLL-----------------DITTIEDVANAAQFIKVRGGLLSNYLLGGEGLAKRAMELGVMKKLQGIIDIGASNVEQHE-------DLLLNTLPLLSILTENVSDL-----NFDSSLNIQLSRILAASTNPDLAEMCLELLHYQAESDEVKLILAKDGLCETIYNLL--------------------EKYKTLASTSEARALMKLACELIVLILTGDDSMHYLYTTPLLKNMVDWLDSTDID---LLTTGVLALGNFA----RTDSHCIYFVEQQTMNKLLE--VLAKNNGVKDDVR-LQHALLSALRNLVIPKPNKNAVIQLVQTILPMLEIHQPPVVFKLLGTLRMTVDGQEKLALELLKN------KTLIEQLVHWSKSSDYAGVTGE---SLRLMAWLIKHAYL-----------------SKIAYALPRKGDAPAEQIADKIPLTQDYDRSSLSEFLANEGTVEAMVSMLTAQHLVMQNEALIALCILSVVYLSQPSEAAQAQLLQDELV-----KCEVGKKLAELISK-----SSDTMTKEIVENLQNCVNLLKSSEQLQHNINELLKSIPIL......................................................................................................................................................................................................................... 628
38 -10.800[S] KOG4646 Uncharacterized conserved protein, contains ARM repeats  ali follow..  7  17LQALVTEFQETQSQDAKEQVLANLANFAYDQLQVLDLFLDSLSEENET--LVEFAIGGLCNLCP-------------DRANKEHILHAIINCLSSPNEETVLSAITTLMHLSPPG-----TPVVQCMLRFSLSASARLRNLAQIFLEDFCSP............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 170
39 -10.800[S] COG5412 Phage-related protein  ali follow..  9  86IDSARAKLKGLGHDA--EAIDSIMDSALASVKGTAFGLDEAATTAANAVAAGIPPGKELTRYLSLTADTAAIAGTSLGETTSGRAYNSELQMLSDRGLPVYQWLAEEANTTA------------DAIFDMASKGEI-----STDMLLNAIEKNIGGAAKIMGEESFSAAIANIGADIARIGANFLDAGGKAGGFFSTVKPLLTEFRGFLA--------QVEEQAADWGVAFGQAFNNVIDRVRELKSWFDGLSPSVQTLITRAVAIGAGFLVGIGPALKVVGFLTTQFGSLLNITSLLLSPIGLVVVGITGLAVAFG-VAMAKSEEFRNLVFGVFQNLASIISTVIATVSPILQT---------------------MWDGAREGLASFAETVGGRLINAFELIVTVLQTVVVAVTEFVSSFIQGFQSAGGEVTSLSSLFLGFNPVLSMALLILQEFGPQIAQGFSQIASMALPLLTMLGQTLGELAAAPMVMNVISALMPVVMSLGMTIMDLAMAIIPILIDV----------SQLLPIITQLVTTFAGIIAQVAP-----LVTILVSSLVPVLMILIETVLNIVQAVAPALIAILGAVAS----------AFDAIIPVVMAVLSTVVNVVANIISAISPIVAFVAGSSIISIISPIVTFIAGIISSIFSV---SPITSFVSGVFSTVFSIISGVFRNILGTVTSAIRTVSSII------SSLSGVVSGVFNRIFSIASSISVITGVFNAIQSTGLTSFVSGVFSGIGNAVQR.................................................................................................................................................................................................. 796
40 -10.700[U] KOG1078 Vesicle coat complex COPI, gamma subunit  ali follow..  8  74..SVTKLFQSK-DTGLRRMVYLIIKELSPSSDEVIIVTSSLMKDMNSKNAIRVLCRIIDGTLLT-------------------QIERYLKQAIVDKNPVVSSAALVSGLHLLKTN-PEIVKRWSNEVQEGIQSRSALVQFHALALLHQIRQNDRLAVSKLVGSLTRGSVRSPLA--QCLLIQRPFYEFLESCLRHKAEMVILEAARAITE---------LDGVTSRELTPAITVLQLFLSSPRP-------------VLRFAAVRTLNKVAMTHPMAVTNCNIDMESLIS------------------------------------QNRSIATLAITTLLKTG--NESSVERLMKQITNFMSDIAD-----EFKIVVVDAIRSLCVKFPLKLMTFLSNILRE---------EGGFEYKRAIVDSIVTIIRDIPDAKESGLLH-----LCEFIEDCEFTYLST-----------QILHFLGIEGPNTSDP--SKYIRYIYNRVHLENATVRAAAVSTLAKFGFM-------------VESLKPRITVLLKRCIYDSDDEVRDRATLYLSEPS............................................................................................................................................................................................................................................................................................................................................................................................................ 524
41 -10.600[U] COG5064 Karyopherin (importin) alpha  ali follow..  9  29.........................................................................................................................................................................................................................................................................................................................................................EEQQIEIRKQKREESLNKRRNL----NAVLQNDIDVEEEADQSQVQMEQQMKDEFPKLTADVMSDDIE---LQLGAVTKFRKYLS-------KETHPPIDQVIACGVVDRFVQFLESEHHLLQFEAAWALTNIASGTTDQTRIVVDSGAVPRFIQLLSSPEKDVREQVVWALGNIAGDSSACRDYVLGNGVLQPLLNILQSLSNLCRGKNPPPNWSTISVAVPILAKLLYSEDVEIIVDACWAISYLSD-----PNEKIGAILDVGCAPRLVELLSSVTGTDAQTQIIIDCGALNAFPSLLSHQKENIRKEACWTISNITAGNTQQIQAIIESNLIPPLVHLLSYADYKTKKEACWAISNATSGGLGQLVSQGVIKPLCDMLNG--SDNKIIQVALDAIENILRTMDLENINQYAVYVEEAMIHDLQSSGNNDIYLKAYSII.................................................................................................................................................................................... 496
42 -10.500[S] KOG3682 Predicted membrane protein (associated with esophageal cancer in humans)  ali follow..  9  14..............AMSEKVRTRLEELDDFEEGSQKELLNLTQQDYVN-RIEE-----LNQSLKDAWASDQ-----------------KVKAL-----KIVIQCSKLLSDTSVIQYPSKF-DILDTFGKLVYERIFSMCVDSRSVLPDHFSPENANDTAKETCLNWFFKIASIRELIPRFYVEASILKCNKFLSKTGISECLPRLTCMIRGIGD-----------PLVSVYARAYLCRVGMEVAPHLKE--------------------LNKNFFDFLLTFKQIHGDTVQNQLVVQGVELPSYLPLYPPAMDWIFQCISYHAPEALLTEMMERLLNSVMSAF--------------RAEFIATRSMD-------------FIGMIKECDESGFPLLFRSLGLNLALADPPESDRLQILNEAWKVITKL-----------KNPQDYINCAEVWVEYTCKHFTKRE--VNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHD------FSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIK-----HQQEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRKVMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLY-ALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFFSPDHPEHGVLFLVRELLNVIQDEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV-----MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAH---DLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMT..................................................................... 809
43 -10.400[IG] KOG1340 Prosaposin  ali follow..  7  23.TPLLGSSKCTWGPSYWCGNFSNSKECRATRHCIQTVWETQKVPVDTDSICTICKDMVARDQLKS-------------NQTEEELKEVFEGSCKLPIKPIQKECIKVADDFL--------PELVEALASQMNPDQVCSVAGLCNGIQAGLDGTVQNEDDSSEETELAMQPNQLSCGNCNLLSRLMHSKFAATDRDDMVETMLHMCGSLS---------SFSDACANIVLTYFNDIYDHVSKHLTTDA---ASRYHQHEEEKQPQEALVALDAGDDIPCELCEQLVKHLRDVLVANTTETEFKQVMEGFCKQSKGF------------KDECLSIVDQYYHVIYETLVSKL-----DANG-ACCMIGICQKNSASSMKDVPIMPLLPVIEPAQVKITIEKLEKHEKKQLGASEPKFSQQEILDMQLPIDHLMGAANPGALVEGGELCTLCEYMLHFIQETLATPSDEIKHTVENICAKLPSGVAGQCREMYGDAVIALLVQGLNPRDVCPLMQMCPKNLPKKEDVEVFNPQPASDEQDPPTCPLCLFAVEQAQMK---RDNKSKDNIKKVLNGLCSHLPNEIKEECVDFVNTYSNELIDMLITDFKP-------QEICVQLKLCPKTTYALWDLRISLEDDVDGEDKSSSEEISFNDIESLEELPPQLAFDPGFTA---------------------APNCLICEELVKTLEKRMGKHPTRDSIKHILEES----------CDRMRKPMNTKCHKVIDKYGDKIADLLLKEMDPKLICTELGMCILADLDDLEVDEALKYDVIALPRQDNKLSSSIKE-LCEFIMTKLDADLKNKTEQDDIKRAIEAVCNRLPATVRKQCDTFVDGYASAVLKLLSDVPPKQVCQK------FSVAVTDEVLECGVCHGVTQALLPFLREKKDNVSEVTALQMTSVGCENLPAKYYKICSEMISIYGSSIKNLAKRP. 924
44 -10.300[S] KOG2611 Neurochondrin/leucine-rich protein (Neurochondrin)  ali follow..  9  22.......................................................................................................................................................................................................................................................................................................................................TEKFAALF--MVTKLVKGKDCNAALFEAIGFPFLKKLPNDCPPLVYKSVALSILTCFCQEEELATHKDIIDAIPTLLEIVEQADDEDYEDNLIVVSEAYSCLKSIASHEPGQQALLATGAIPKMSQIY---SAQSFQTDEALHLIVLLVKQFGVVSWPEDPTAFHALIQRIALDMETDDTERKYELCRILADILITCRREIVINSLEG-QIWPESLFKGCGDILKAKIGPKQRDPALHLIATTLHVLGAFMDEQKTFFLQLLQLGAIEVRMQMDEKKLETTQAELLTCCFSILEHCIEYMATDQLDLEPKEKQTTYTALKGAFNQVLAVLTRVSQDKIRESSNPKDKKFVFAIVKVLSAWLAQETTAMRPAIYKLLPFMLKVANESFQELKTWRAGIDVLRIMLPALCHFAVEEEARRVLFTHKQDEVLLESLEFYFSIAHWKRPPIPRAERLKRMNEPDPVPAIVALCNILMNFTVLEPKKAEDGPTFANLLKFVVENLPELKDTPDNLVIHLAVLGLLLLKQQSKKVKQNDFSICRYIQATIRFLWDAYNIDESNDPTALVVSI------AYKGYWSDLSELWFLGMQTMCGVLPLVPWLSEFALESGEGIVKTLKKVKIGTLPANVKSAYEDFLSQL 688
45 -10.100[O] COG5021 Ubiquitin-protein ligase  ali follow..  8  20......................................................................................KPLVDYLIDCDTP---TFLERIEAIQEWDRSRVWIPILDRM----------------GLLLKVAEKYKYKQDPKK--------------------ECEVKLVEMEAHDVDYCLKMLKFTRRLLL-----------NTENRFVYSSGDVLMYLLNCPN-------------FTIKLAVMRILAILGERFVIAREKIVAHNIFGDHNLRKKTLKLALSLSSSVMDEDGEHFSLVDLYFDKKKVPQKWRKLRFTHYTSNDFKKSSQQKNNINETQTSIKK-VTMTTQELCEHSLQQIFDKGMALLPAESWFDFSIKA-SVAKAFSDDSGENIDLRNIIIETKLNAIAFVNTIFSPPQVSSKLFELDPYAFNSLTDLISLSETKIPKELRTDALFTLECISLKISHGLLFQILRYIAKTLREATDEIDEEYNVRFFYLISNLADVKPLHES-----FAAGLIPTLLEIV-SIRNCPYKRTLASATHLLETFIDNSETTTE--FTMLITSVANEIDFTLAHPETSFRELAYIRSLLKLVLKLLSTDSGDRIRIDSPILVSLKKILENKLLTLITYTLDVVQKVINSEPTIYPVLVEAGLIPYVIDNFPKLSAELLSLLPDVVSAICLEGLKQVKEKGLINNLFDFLLRILTGGDRSTEYGTDIDELARHYP-----DLKANIVEALCNVIRKPAYWELLDKGTMLDTFTSVLFGMSLGNGSFSQVPQHLEARDFLAII------FMENPPYEYFTSVAISNVTEVLQY----LDEKYEDYAFMDVMKVLNDQLENLNDFLNSPNDRSFFLERDGENSVRSCHS--------------LCRLAAILNIVTNVYIDLTTLSCKRIMQ-IYSYFDKRGFSLIKNLKL.. 888
46 -10.100[T] KOG2137 Protein kinase  ali follow..  8  1.......MSINMK-----TFTQALARTAAVIEKTVHTTVQEVTGPKALQDYELLDQI--SAGPGLAWRPQQYPTVCVWMLDKRALSEARVRA-KAAEDAFLDLIRADAGKLVRLRHPG--------VVHVVQA-------------------------LDENKNAMALVTEPLFASVANALGNVENVGNVPKDLKSMEMSLLEVKHGLLQISETLNFLH-ENVLITSAGSW-----KLAGFGFAISAAQAGNLDNMQSFHYSEYDVEDSILPVQPSLNYTAPELMRSSFGCLAYHLVARKPLFDCNNNVKMYMNTLNYITNESFSSIPSELVSDLQRML--------------STNESF--------------RPTALDFTGS--NFFRSDARLRALRFLDHLLERDNMQKSEFLKALSDMWKDF-----------------------SRVLRYKVLPPLCAENLVLQPIILPMVLTIAQSQD---RTDFELITLPALVPVLSTASGDTLLLLVKHADLITNKTDSEH--------------LVSHVLPLLLRAYNDNDVRIQEEVLKRSTSVAKQLDGQV------VRQAILPRVHGLALKTTVAAVRVNALLCLAELVQTLDKPA------AIEILETIQRCTAVDRSAPTLMCTLAVANAILKQYGVEFTAEHVLTLMMPLLTA--QLNVQQFAKYMLFVKDILRK.................................................................................................................................................................................................................................................................. 614
47 -10.000[U] KOG2604 Subunit of cis-Golgi transport vesicle tethering complex - Sec34p  ali follow..  7  1MATKAASSSSLPKSGAISKGYNFASTWEQSAP--IVSLSHAVAETDLESAMKSETEEKYRHYVSTLTERIQTCDNILHQAGFQQVDETLFNELQLQHQGVTTKTKTLHDACDRLMEKQKLMEFAEALRSKLNYFDELENSRALGMIRTYILA------------VLKTAASQAAFRGTGGNKTSVSEGVEASVIYVRFKAAANELKPVLEEIESSARKEYVQILAECHRLYCEQRLSLVKGIVHQRVSDFAKKEALPSLTRSGCAYLMQTMAGLSALATEDNGFGFAEHEISAPHLVHILKVEVLGDQSARQSEPLA--------TLQRILADVNERLTFRARTYIRDEIANYTPSDEDLEGSPNTTSETDLRDDENADVFKTWYPPLEKTLS--CLSKLYRCLEQAVFTG----LAQARLSEAVEVCSLSIQKASKLIIKRSTTMDGQLFLIKHLL------------ILREQIAPFDIEFSVTHKELDFSHLLEHLRRILRGQASLFDWSRSTSLARTLSPRVLESQIDAKKELEKCLKTTCEEFIMSVTKL-----------VVDPMLSFVTKVTAIKVALSSGTQNHKVDSVMAKPLKEQAFATPDKVVELVQKVYLRNRDGSYFLFPMKHDIENSVHRQFVYAAIQQELLPILAKMKLYLQNPSTRTI----------LFKPIKTNIVEAHTQVESLLKAEYSAEEQANINMISIQDLQTQLDNFL............................................................................................................................................................................................................................................ 745
48 -10.000[T] COG5635 Predicted NTPase (NACHT family)  ali follow..  9  473.EQLKVYICDSSKKEDTRRIAIDIAI-ECNLSELQGDLAKLTLCPSQPISIRVNAARAISSI---------------DQSTRLKLKSLALNVLPEDQDELKAYALKAL-----------WPRQLTELFQALTPSKRINLLGMHRLESELVPQLDSEDLVIALDWLKTQGVRCFGHPFEELGDAILLKAWEHVNVPGVLEGFTQVALLQWKEHQKLISPSLQAQFQESLLGNNQKRYALIENLVESIAEKDEDEDFYFLTSSMTEPIIS-------------SNDVDWMLEKLQDSNHEKIQRAWAKIIEEVFDRRDTKQISEIIKATQN--NSILSDVFSYYFTPIELDSEEVTQLRDHYLKMKNSWNKPDLLDPPPKERVIDCLEQLESGDLSAWWRLNREMTLLPQSKRYGHNLKLDLT--------------------------------------------------------------KEAEQATKKRIIQGAIQYIQQQTNIDYLYGCKALQLILTEAPRTLDNFSTDIWKRWTPIILSVPNSFIDSNPR-------KNCRKLVSLSYHHSPDEFLTTLLKLIDKENQDNNIFVIDRLEMCWDEKLENNLTEKVKDSQLK--------PNVFRKLLEKLIEQGAVQAKDIALSTIRNYTNSEFDSERQKALFAIKALIIWEKITADVQFGREAFELAASCNLSGIKFDLTEKQIADLYAWLVWQYPHYEDPDHRNEVMAYIV------SPRDNIAFFRNNSLSQLRDKGTIEACAE--------------------LERLIQELPHLPWLKETLT---YAQQNMRRETWRPFKPDKLLEFLIIPEPSNLDLSNQ------LSTIDKRTEKMEDEPKIINNISDSTINAPVGTSGVTSNNVTCSSPEKQKRFNWE----ILFGVIGIIGVIATVVGIFFNGIFNDVLKDSLNGSSKIEQQAM 1316
49 -9.940[R] KOG1243 Protein kinase  ali follow..  8  1...MWSFFSRDSSKDFPYDIGEPVGGFDQYS-----------------------------------WTKTTLEEVSVFVYDIRSGSDTKCELAKAALKRLKT----------------RHPSILQYLDSLETDKMLYVATEAVDPLGTYFSKLGSDNVQKGL--YLAWGIFQITRAL-SFLNNDGNLRHNNVSAWSVFVNASGEWKLPAKIPVTLEVYDSPEKNDPSKLK-MWGLGCLVWEAFNGVLKQRSNLKDIEHIPKSLQSLYCELVGASPSNRPNPADIIT------------------------------------RCRKPGGFFKNDLVDTLLFLEEIQIKD----KAEKNRFFSGLTTHLDNFPDNVCRHKILPQLITAYEGDAGSAVLAPMFKLGKLLDEVE----------------------------------------YQKRIVPCVVKLFASTDRVTRSRLLQQLDLFIAHLQPQVVNDIFPQVAHGFLDTNATIREQTVKSIIHLAPKLNYNNLN----------VEVLRHFARLQARDDQGGIRTN---TTVCLGKIAPHLHPQV------RQRVLVSAFIRAMRDPFPPA-------RVAGVLALAATQQYFLLSEVANRVLPSLCSLTVDPEKTVRDPAFKTIRGFLGKLEK......................................................................................................................................................................................................................................................................................................... 539
50 -9.840[DT] COG5261 Protein involved in regulation of cellular morphogenesis/cytokinesis  ali follow..  8  422IQTLQSIIRGGFYRRKYHSLIERLDLFTPSFVLIQSSALGFLTRHAIVNMLDNLLFNRMQSILRANMFRNEWSNFLDSVQSHSICKGRLIR---DSINRLNGSLLGELDNFIKLQ--RAFKEKLEKLKASTSS---------FIALQAIVRAFLLRKNLESIYDSFQKSHLSVIK-----AQSLYRGFITRTKIDYCNDYLLKRLPDIVFMQSAVRAILLRDDVNYTEVQLDSFIPEIVLLQS-SRNKFSRKLQNFHKNMENPIVAKSIF-LAYRELATAKNPPVMTVKNFVHLLDDTNFDFEEEVLLEKMRKEIVQQVRDNEEIEVHNELDVKIALLVKNKISLDDNKYKFGKQSTEYLKINTLSMKSLNNSSRKFLELYQCFFYVLQTN--EMYLANYFQALKTEGTSSVKIRHAVYLVLQIFG-----------HGSNRREEVLLLRFISQVIKLEAALVNSSQDLLSDDCVWLFTGYRGDVREVKLWKTILRIHKVLVADNHLDFEINPLTLFKSFNPEVATLSLAMQHPPTRNLYVSRLRELRKLCQS------------FLVALSKNIENIPYALCYTAAQLKNSLQRYFPAAHKEEIFGVIGKFVYWAVAPVL-------------VSPDNFKLVDGSITALQRKNLYTLSSILSEIFSIESCDSKQLGFFRPLSEFIEVSKQDTMLMLERLVDVIYSSIAYVIDSIAPPDVNDPLRAVVNSLGPVSEQDNDFVQDETDVKLELNPKFCT-----------IENPVAQERTLIVQTKRYILFIIRIQNGLNLLEILVKPVTDSDEAAWQNLLAEE-FDDSIFSMSFAELKYTALSNIVEMEKLGFANRRNNYQDMVNSIALDIRNKSRRRMQRQRELDAGHQSLLNLREKRAFLDS-----------------QLKSYNEYIEQAMETLQSKKGKK........................ 1367
51 -9.650[G] KOG2175 Protein predicted to be involved in carbohydrate metabolism  ali follow..  10  1...........MSDTRRRVKVYTLRQWDDRGTGHVSSTYVLLVRAESDGSLLLESKINPNTAYQKQWSEAENYDLALSFQEKA---DEIWEKICQVQGKDPSVEVTQDLIDESEE---------RFEEMPETSHLIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALEGYIKKLLQLFQACENLEN------------TEGLHHLYEIIRGILFLNKATLFEVMFSD--ECIMDVVG-----------------------------------------------CLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFEE---------------------------NFLSTLTSFIFFNKVEIVSMLQEFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFS---------------TLQPQNRDAFFKTLAKLG-----------------------------ILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQSDDDLLINVVIEQMICDTDPELGGAVQLMGLLRTLIDEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKDFFLKHYSWSFICTPSHSHSHSTPSSIVGSNKNNTICPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRVLVLMNSKHTFLACALRFMRRIIGLKDEFYNRYITKGNLFEVINALLDNGTRYNLLNSAVIELFEFIRVEDIKSLTAHIVENFYKALESIEYVQTFKGLKT...................................................................................................................................................................................... 677
52 -9.550[K] KOG2434 RNA polymerase I transcription factor  ali follow..  7  1...MAAPLLHTRLPGDAAASSSAVKKLGASRTGISNMRALENDFFNSPPRKTVRFGGTVTEVLLKYKKGETNDFELLDPDIKDDQIINWLLEFRSSIMYLTKDFEQLISIILRLPWLNRSQTVVEEYLAFLGNLVSAQTVFLRPCLSMIASHFVPPR---------------------VIIKEGDVDVSDSDDEDDNLPANFDTCHRALQIIARY------------VPSTPWFLMPILVEKFPFVRKSERTLECYVHNLLRISVYFPTLRH--------------------------------------------------------EILELIIEKLLKLDVNASRQGIED-TEGLFNMDEDEETEHETKAGPERLDQMVHPVAERL-DILMSLVLSYMKDVCYVDGKVDNG---KTKDLYRDL------------------------NIFDKLLLPTHASCH-----------VQFFMFYLCSFKLGFAEAFLEHLWKKLQDPSNPIRQAAGNYIGSFLARAK-----IPLITVKSCLDLLVNWLHIYLNNQDSGTKAFCDVALHGPFYSACQA-----------VFYXFVFRHKQLLSGNLKEGLQYLQSLNFERIVMSQLNPLKICLPSVVNFFAAITNKY.................................................................................................................................................................................................................................................................................................................................. 520
53 -9.530[L] COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)  ali follow..  10  59.RLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLNRASISTLHS---FCLQVLKKYYYLIDLDPGIADQTEGELIGDEVLDELFEHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPFYQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSELYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTSPEQHLKSLAEMKPVIETLVQLVISYGKRFEAAKQ-IIDFSDLEHYCLAILTAENDKGEREPSEAARFYQEQFHEVLVDEYQDTNLVQESILQLVTSLFMVGDVKQSIYRAEPLLFLSK----YKRFTESGEGTGRKIDLNKNFRSR--ADILDSTNFLFKQLMGGKIGEVDYDEQAELKLGA-----------AYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSPFKV---KKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVVAVALSVLKVIDNPYQDIPLASVLR--SPIVGADENELSLI--RLENKKAPYYEAMKDYLAAGDRSDELYQKLNTFYGHLQKRAFSKNHSVSELIWEVYRDT---------------YMDYVGGMPGGKQRQANLRVLYDRARQYESTAFRGLFRFLRFIERMQERGDDTIHSSKGLEFPVVFVAGLGRNFNMMDLNKSYLTLPLIAMKKKMRRELLSEELRVLYVALTRAKEKLFL........................................................................................................................................................................................... 880
54 -9.380[U] KOG2347 Sec5 subunit of exocyst complex  ali follow..  7  171...LIENHSNTSFEQLKMAVTNLKRQANKKSEG-----SLAYVKGGLSTFFEAQDAL-IHQKLEA--DGTEKVEGSMTQKLENVLNDTLFQEVLGRKDKAD-STRNALNVLQRFKF-----NLPLNIERNIQKGDYDVVINDYEKAKSLFGKTEVQV--------FKKYYAEVETRIEALRELLLDKLLETPSTLHDQKRYIRYLSDLAWQCIGAQHKWILQLMHSCKEGYVKDLKGNPGLHSPMLDLDNDTRPSVLGHLSQTASL-DTWRYKTPHRVAFVEKLTKLVLSQLPNFWKLWISYVNGSLFSETAEKSGQIERSKNVRQRQNDFKKMIQEVMHSLVKLKCELSGQWLAHAIQTVRLTHESLTALEIPNDLLQTIQDLILDLRVRCVMATLQHTAEEIKRLAE--KEDWIVDNEGLTSLPCQ-----------------------------------------------------------EQCIVCSLQSLKGVLECKPGEASVFQQPKTQEEV-----------CQLSINIMQVFIYCLEQLSTKPDADIDTTHLSVDVSSPDLFGSIHEDFSLTSEQRLLIVLSNC--CYLERHTFLNIAEHFEKHNFQGIEKITQVSMASLKELDQRLFEPIVGSLEPGITGVRNYLKEALVNIIAV--HAEVFTISKELVPRVLSKVIEAVSEELSRLMQCVSSFSKNGALQARLE--ICALRDTVAVYLTPESKSS--FKQALEALPQLSSGADKKLLEELLNKFKSSMH................................................................................................................................................................................................... 908
55 -9.180[O] COG5113 Ubiquitin fusion degradation protein 2  ali follow..  8  1MTAIEDILQITTDPSDTRGYSLLKSEEVPQGSTLGVDFIDTLLLYQLTENEKLDKPF---EYLNDCFR-------RNQQQKRITKNKPNAESLHSTFQEIDRLVIGYGVVASQIENFCMNGAFINYITGIVSNVNSYT-----DFLSQIIQRAILEGTALDL---LNAVFPTLLEYCNKHVSHFDLNESVIYNNVLTIFELFVTFKPIAEIFTKIDGFFADYSCKPQDFERKTILGPILSLSP----EAAVAIRNYGDNLLRSKQQTAMIHESLQAEHKVVIDRLFFIVDKLVRGSLNSRTDMISYFAHIANKNHLRRADHPPFKELSSNITLLLVRFSQPFLDISYKKIDK---DANYFNNPSLFIDLSGETRLNSDF-LGGTLSFEEKMGIKALKEEIEKVKKIAANHDVFARFITKTTESLRFALQGFFAHRSLQLEVFDFICGASTFLIRVVDPEHEFPFKQIKLPLIPDQIGVENVDNADFLRAHAPVPFKYYPEFVVEGPVNYSLYISKYQTSPIFRNPR-------------LGSFVEFTTMVLRCPELVSNPHLKGKLVQLLSVGAMPLTDNSPGVNKNLLYALLDFYVIVEKTGSSSQFYDKFISIILEELYYKIPSYKNQLIWQSQNNADFFVRFDARMLNDLTFLLDEGLSNLAEVHNIQNELDNRARGAPPTREEEDKELQTRLASASRQAKSSCGLADKSM--------------KLFEIYSKDIPAAFVTPEIVYR---------LASMLNYNLESLVGPKCGELKVKDPQSY---------------------SFNPKDLLKALTTVYINLSEQAKDERSFNRNLFVRAVDILGRKTGLASPEFIEKLLNFANKAEEQRKADEEEDLEYGDVPDEFLD-----------------MYTIMKDPVKMNID-RSTIKAHLLS-DSTDPFNRMPLKLEDVNEELRQKILCFKKQ. 950
56 -9.100[J] COG5593 Nucleic-acid-binding protein possibly involved in ribosomal biogenesis  ali follow..  9  54........................................................................................................................................................................................................................................................................................................................................................VNVDHVSELETRGLLLLKEDSERFSETLGHGTADKRMLQTLISSGT-----TSDRISALTLLVQESPIHAVKALETLLSIC--------SKKSRNEATQAITTLKDLFIGGLLPDRKKQQSCLGSKNVTDKHLMVWAFESFL-KSFYFKYIQIIEALSFDALLFVKSQMVSTIYDLLKAKPEQE------------QNLLKLLINKLGDKENKIASKASYSILQLEAS---------PAMKLVITKEIERFIFAPSTSRTSCYYTLITLNQT-----VLTHKQVDVANLLIEIYFVFFTKLLFALEKEEVADAPTLEKKSLQSDSKNKKSQKRKKDEDLRKEAEENVNSRVISAVLTGVNRAYPFAEVN-------EKFDKHMNTLFAITHTASFNTSVQVLMLIFQASASRDFISDRYYKSLYESLLDPRLTTSSKQSLYL--------------NLLYKSLIIDNNIPRVRAFI---------------KRMVQVSAW---QQPPLVTGLFHVMHQLVIATTALRSMFTNAEIHDFDGDEEEVFKDVEEDDVSEDQKVDSDKDGKLSDKRDPQYEIHPFLNHFHPTVSLLAKS............................ 610
57 -9.070[O] KOG4413 26S proteasome regulatory complex, subunit PSMD5  ali follow..  8  2..................................................................................................................................................................................................................................................................................................................................................................EDVNQLFD-------------AAFEFAHYPGAQNETSVKEFLDRFPLPVIFNALQTDPDIPGFENTLVTCLERLFKTKYGA-----------SLIPQYMPVLQVGLKADSAVVKSLACKTVLCLLEDCDTNDVSSV-NGIYPLLLDYIINSDDEVANAASETIKSLARFPDAMSVIFPSETNDPTH-RVLSLIVKLFSISRLVASEVKKSGLLDLLEAEMKGTKDTLVILNTSLIQLLCSIISGTSTGPYEKLRAMMISGRLLSKENIYKVVEEASVKALISAIDGSLE-SVEMNDTDAQEAAIDALGQMGSTTKGADLSTSPPAARHVVASAFDRNAHGKQLAALHALANIAGETRPK-STKLTPSGLFLSVLQ----SEIRLAGYRTLTALVARPWCLVEILAKEEIINIVTDATTETAKIAMEARYNCCKAIH................................................................................................................................................................................. 471
58 -9.010[U] KOG1107 Membrane coat complex Retromer, subunit VPS35  ali follow..  9  3........................................................................TTQQSPQDEQEKLLDEAIQAVKVQSFQMKRKLMDALKHASNM--PKSYYELYMAISDELHY------------LEVYLTD---EFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVKSFPQSRKDILKDLVEMCRGVQH---------------PLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSMDFVLLNFAEMNKLWVRMQHQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERY-KQIVLTGILEQVVNCRDALAQEYL-IIQVFPDEFHLQ------------TLNPFLRACAELHQNVNVKNIIIALIDRLALFAHREDGPGIPADIKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMKCYPDRVDYVDKVLETTVEIFNKLNLEATSSAVSKELTRLLKIPVDTYNNILTVLKLKHFHPLFEYFDYESRKSMSCYV----------LSNVLDYNTEIVSQDQVDSIMNLVSTLIQDQPDQ-------------------PVEDPDPEDFADEQSLVGRFIHLLRSEDPDQQYLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKENSKVDDKWEKKCQKIFSFAHQTISALIKAELPLRLFLQGA-ETVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTFMKCFSEENHEPLRTQCALAASKLLKKPDQGRAVSTCAHLFWSKRVMECLKKALKIANQCMDPSLQVQLFIEILNRYIYFYEKENDAVTIQV-LNQLIQKIREDLPNLESSEETEQINKHFHNTLEHLRLRRESPESEGP................................................................................. 789
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.