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Query: [OR] KOG0001 Ubiquitin and ubiquitin-like proteins, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEVFLRTSSVSSSLESSLRMDVLWPTTTSRRSLLFTWSCVFVVVSKSRLCYALast
1 -132.000[OR] KOG0001 Ubiquitin and ubiquitin-like proteins  ali  100  1MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEVFLRTSSVSSSLESSLRMDVLWPTTTSRRSLLFTWSCVFVVVSKSRLCYA 464
2 -48.300[J] KOG0004 Ubiquitin/40S ribosomal protein S27a fusion  ali follow..  52  1MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMASHFDRHYCGKCCLTYCFNK......................................................................................................................................................................................................................................................................................................................... 152
3 -44.100[J] KOG0003 Ubiquitin/60s ribosomal protein L40 fusion  ali follow..  61  1MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG---IIEPSLKALASKYNCDKSVCRKCYARLPPRATNC--RKRKCGHTNQLRPKKKLK........................................................................................................................................................................................................................................................................................................................................... 128
4 -38.300[K] KOG4495 RNA polymerase II transcription elongation factor Elongin/SIII, subunit elongin B  ali follow..  18  1MDVFLVIRRHKTIFTDAKESSTVFELKRVVEGILKRPPDEQRLYKDYQLLDDGKTLGECGFTSQTAR----PQAPATVGLAFRAHDAFEALCIEPFSSPPELLDVMKPQESGSSANEQAV........................................................................................................................................................................................................................................................................................................................................................ 117
5 -35.800[O] COG5272 Ubiquitin  ali follow..  94  1MQIFVKTLTGKTITLEVEPSDSIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG.................................................................................................................................................................................................................................................................................................................................................................................................... 76
6 -33.900[DO] KOG0005 Ubiquitin-like protein  ali follow..  54  1MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGGGGL................................................................................................................................................................................................................................................................................................................................................................................................. 79
7 -31.900[O] KOG3493 Ubiquitin-like protein  ali follow..  23  2IEITCNDRLGKKVRVKCNPDDTIGDLKKLIAAQTGTKHEKIVLKKWYTIFKDPIRLSDYEIHDGMNLELYYQ........................................................................................................................................................................................................................................................................................................................................................................................................ 73
8 -24.500[L] KOG0011 Nucleotide excision repair factor NEF2, RAD23 component  ali follow..  25  3VTITLKTLQQQTFKIRMEPDETVKVLKEKIEAEKGFPVAGQKLIYAGKILSDDVPIRDYRIDEKNFVVVMVTKTKAGQGTSAPPEASPTAAPESSTSF.............................................................................................................................................................................................................................................................................................................................................................................. 103
9 -22.800[OR] KOG0010 Ubiquitin-like protein  ali follow..  35  37MKVTVKTPKEK-EEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDTLSQHGIHDGLTVHLVIK........................................................................................................................................................................................................................................................................................................................................................................................................ 107
10 -22.000[T] KOG1363 Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains)  ali follow..  13  103...FRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPMLIITHREVQREYNLNFSGSSTIQEVKRNVYDLTSIPVRHQLWEWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENLEAAFQEAFYVKARDRKLLAIYLHHDESNVFCSQMLCAESIVSY-----------LSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTFLIIMGKRSSNEVLNVIQGNTTVDELMMRLREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKPVSKLRIRTPSGEFLERRFLASNKLQIVFDFV-ASKGFPWDEYKLL-LDPNKSLLEVKLFPQETLFL................... 646
11 -17.700[O] KOG1769 Ubiquitin-like proteins  ali follow..  17  17INLKVAGQDGSVVQFKIKRHTSLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLRMEDEDTIDVFQQQTGG.................................................................................................................................................................................................................................................................................................................................................................................................... 92
12 -17.500[A] KOG0007 Splicing factor 3a, subunit 1  ali follow..  35  697VTIQVLVLNGQMIAVTMALSEPIANLKTKLQDETGMPPAKQKIFYEGMFFKDSNTMAFYNLVNGTTVHLQVKERGGRK.................................................................................................................................................................................................................................................................................................................................................................................................. 783
13 -17.300[S] KOG2827 Uncharacterized conserved protein  ali follow..  11  2.........................SATKHNERVGRRNDRKRDASQACLPERSPSLRSEPRQQRSHPY-------------------------------------LQTRTNTHRQRPMIRPSSVVSMSGRSISDSSENDDRHFDVDEEMESMSLDSPLPIEVPARPFPDKPYYWMNDYKTLEFIRTNFPSDSFYVMHNGKIIENFNAFIDENMGQSLVK---------YSFHLRVRGGKLRSFRVNKSTNKLMMRDL---------NGRRM----ASVDEEAKLKRYLEKQARKEQELKEKRKAKLEKLTAGPAKHMFEDQDYLSRREEIINKTEDA............................................................................................................................... 262
14 -17.000[O] COG5227 Ubiquitin-like protein (sentrin)  ali follow..  13  36INLKVVGQDNNEVFFKIKKTTEFSKLMKIYCARQGKSMNSLRFLVDGERIRPDQTPAELDMEDGDQIEAVLEQLGG.................................................................................................................................................................................................................................................................................................................................................................................................... 111
15 -16.900[L] KOG0012 DNA damage inducible protein  ali follow..  10  1MKITVTTSDDKVFCLDVAQDLELENLKALCAMEIGAEVSQIAVIFNGRELSDKQTLQQCGVGDGDFIMLERRRSANRPVGGNPAISTLDFSNIAVPGTSSG-GVQQPQFNNLTDIPTTDEFNVNFDDDPETVRQMFLSSPETLSLLRQYNPSLAEAIDS----------DKEKFARLLREHITERKRRNEHRMRMLNADPFDEETQRLIAEEIKQKNIQDNMAAAIETMLYINCKVNGIPVKAFVDSGAQTTIMSKDCAERCHV-----------RLIDTRWNGVAKGVGTQPIL------------------GRIHMVQLQIENDHLTSSFTV-----LGQQPMDMLLGLDMLKRHQCLIDIGTTGTTTPFLPESELPVSARLTGNSEDSMEQEAISNAIEQSKRESGGAGGGPNTISPQERFTEQDVTDLMALGYPRSDVLTVLRLCGGNKQAARS...... 443
16 -16.900[O] KOG0006 E3 ubiquitin-protein ligase (Parkin protein)  ali follow..  24  1MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGL......................................................................................................................................................................................................................................................................................................................................................... 119
17 -16.500[S] KOG0013 Uncharacterized conserved protein  ali follow..  11  114..................PKIVARIPRAFAERKDSLDDEDDNMISSNDPTKSPEEHDTTTKSIASLKDAELDSSLETVLIRYSKDDKDYSIQINPNLPFSHAKSQLE--EVGLENVQRFFFLGRVLQFKKSLSQQGWTSGMIIQAM.............................................................................................................................................................................................................................................................................................................................. 239
18 -16.500[S] COG5417 Uncharacterized small protein  ali follow..  11  9VTVDFTNWGADKYDLRIPVHQPIKALIINLAETLKIEYKDLKTTNKAILLSDDDKLTNFQIADGDILEIL.......................................................................................................................................................................................................................................................................................................................................................................................................... 83
19 -16.400[T] KOG4361 BCL2-associated athanogene-like proteins and related BAG family chaperone regulators  ali follow..  10  51IRVRIKY-GAVYHEINISPQASFGELKKMLTGPTGIHHQDQKLMYKDKERDSKAFLDVSGVKDKSKMVLIEDPLSQEKRFLEMRKIAKTEKASKAISDISLEVDRLGGR--VSAFEMVTKKGGKIAEKDVTVIELLMNELIKLDAIVAE----------------DVKLQRKMQVKRVQNYVETLDALKVKNSM.............................................................................................................................................................................................................................................................................. 227
20 -13.600[O] KOG4583 Membrane-associated ER protein involved in stress response (contains ubiquitin-like domain)  ali follow..  16  29VRLLIKSSNQQDLNVDSDLCWTVQRLKKHLSLI---LIQDQKLIYSGKLLDDSQKISEV..................................................................................................................................................................................................................................................................................................................................................................................................................... 91
21 -10.800[YU] KOG2834 Nuclear pore complex, rNpl4 component (sc Npl4)  ali follow..  10  5IIIRVQSPDG-VKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNK-SSNKSLNLLKIKHGDLLFLFPSSLAGPSSEMETSVPPGFKVFGAPNVVEDEIDQYLSKQDGKIYRSRD---PLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWP-------ICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGN---------QQFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKLGL---RKVGWIFTDLVSEDTRKGTVRYS-RNKDTYFLSSEECITAGDFQNKHPNMCRLSPDGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKD........................................................ 405
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.