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Query: [Q] KOG0022 Alcohol dehydrogenase, class III, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILPFEKINEGFDLLRSGKSIRTVLTFLast
1 -110.000[Q] KOG0022 Alcohol dehydrogenase, class III  ali  100  1MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILPFEKINEGFDLLRSGKSIRTVLTF 375
2 -107.000[C] COG1062 Zn-dependent alcohol dehydrogenases, class III  ali follow..  47  1.......MKSRAAVAFAPGKPLEIVEIDVAPPKKGEVLIKVTHTGVCHTDAFTLSGDDPEVFPVVLGHEGAGVVVEVGEGVTSVKPGDHVIPLYTAECGECEFCRSGKTNLCVAVRETQGKGLMPDGTTRFSYNGQPLYHYMGCSTFSEYTVVAEVSLAKINPEANHEHVCLLGCGVTTGIGAVHNTAKVQPGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPKKFDLARRFGATDCINPNDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRAALESAHRGWGQSVIIGVAGSGQEISTRPFQLVTGRVWKGSAFGGVKGRSQLPGMVEDAMKGDIDLEPFVTHTMSLDEINDAFDLMHEGKSIRTVIRY 369
3 -61.900[Q] KOG0023 Alcohol dehydrogenase, class V  ali follow..  21  1MAKSPEPNKVFGWGARDKSGVLSPFHFSRRDNGENDVTVKILFCGVCHTDLHTIKNDWGSYYPVVPGHEIVGIATKVGKNVTKFKEGDRVVGVISGSCQSCESCDQDLENYCPQ--------------MSFTYNAIGSDGTKNYGGYSENIVVDQRFVLRFPENLPSDSGAPLLCAGITVYSPMKYYGMTEAGKHLGVAGLGGLGHVAVKIGKAFGLKVTVISSSSTKAEEAINHLGADSFLVTTDPQK------MKAAIGTMDYIIDTISAVHALYPLL-GLLKVNGKLIALGLPEKPLELPMFPL-VLGRKMVGGSDVGG---MKETQEMLDFCAKHNI---TADIELIKMDEINTAMERLAKSDV-RFVIDV 353
4 -59.700[ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases  ali follow..  23  1.........MKAIVWQGVNK-VGVETVPDPTLLPTDAIVKITSTAICGSDLHLLDGYIPMETGDILGHEFMGEVVEVGSEVRKLKVGDRVVVPFNIACGVCDPCKRGFFSACDNSNPNHRAEALYGATSGGALFGYSHMYGGYAGGQAQYVRVPDVGPFKIESGLKDEQVLFLTDIFPTGYQAAEQCNIVPGRDVVAVFGAGPVGQFAARSAQMLGAAHVIVIDRVPERLAMAEAAGCQTI--NYEKEDVLLSLREATGGRGPDHVIDAVGMEAHGHGPAILSCAKGGTVSMPGVYGGLVDKMPIGAAFAKGLIFRM---GQTHTHRHIPSLLGRIEAGQIDPSFVITHRASLDQAPELYKTFRDKQCIKVVLN. 389
5 -57.000[Q] KOG0024 Sorbitol dehydrogenase  ali follow..  23  2..AAAAKPNNLSLVVHGPGD-LRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPD---------------------GNLCRFYKHNAAFCYKLPDNVTFEEGALI---LSVGIHAC-RRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESQEIARKVEGQLGCKPEVTIECTGAEASIQAGIY-ATRSGGTLVLVGLGSEMTTVPLLHAAIRE------DIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIML.. 348
6 -56.900[R] COG1064 Zn-dependent alcohol dehydrogenases  ali follow..  23  1......MAIARGYAATDASKPLAPFTFERREPRDDDVVIDIKYCGVCHSDIHQARDEWGSTFPMVPGHEIVGIVRAVGSQVTRFKIGDRVVGCFVDSCTTCAKRDLDLEQYLPG--------------LVVTYNGVEADGTPTQGGYSDHIVVKEGYVLSIPENLPLDAAAPLLCAGITLYSP-LRHWKAGPGKKVAIVGLGGLGHMGVKLAHAMGA-EVTVLSQTLSKKEDGLKLGADHYYATKDPET------FTKLAGSFDLIICTVAAEIDWNAYL-NLLKVDGELVLVGIPENPVPVHAFSL-VPARRSISGSMIGS---IKETQEMLDFCGEHGI---VSEIETIRMEQINEAYERVVRSDV-RFVIDM 342
7 -44.200[CR] KOG1198 Zinc-binding oxidoreductase  ali follow..  23  1.......MALRYVVHDEISGFDQLKPEEYEVPNPGEVLVKLKAASLNYRDLIITKGLYPLPLPVVPGSDGAGIIEKVGEDVEGFEKGDSVVCNF------FTNYLDGTPTDFATHSAL---GGTRDG------------------CFQKYAVLPAHALVHAPKNLSFEEIATLPCAAVTAWNGLFKEHQVKPGNNVLVLGTGGVSTFALQFALAAGA-NVTVTSSSDEKLEFAKKLGATHTINYKKTPQWASPALKMTNGVGYHHVIEVGGEKTLPQSI--ACLAKDGMISMIGFVASEGTTSIIGQILNRNANIRGIFVGSVSMFRDMVACIEAK-----DIHPVVDKVFPFDQLKEAYEYQWSQAHIGKVVL. 343
8 -40.300[CR] KOG1197 Predicted quinone oxidoreductase  ali follow..  21  2.........VKGIRVYEHGGPLKWEDVEVGEPKEGEIRVKNKAIGLNFIDVYFRKGVYKASMPFTPGMEAVGEVVAVGSGLTGRMIGDLVAYAGNPM-----------------------------------------------GAYAEEQILPADKVVPVPSSIDPIVAASIMLKGMTAQFLLRRCFKVEPGHTILVHAAGGVGSLLCQWANALGA-TVIGTVSTNEKAAQAKEDGCHHVIMYKN-EDFVSRVNDITSGKGVNVVYDSVGKDTFKGSL--ACLKSRGYMVSFGQSSGSPDPIPLSDLAPKSLFLTRPSMMHYNETRDAGEVFANVTSGILKA--RVNHKYPLSRVADAHADLENRITSGSVVL. 322
9 -39.300[KC] KOG0025 Zn2+-binding dehydrogenase (nuclear receptor binding factor-1)  ali follow..  20  8RSALQRAASTRQLVYEGYRNPIQLKTVTIADPSADQVLVQWIAAPINPADLNQIQGVYPVALPAVGGNEGFGKVISVGSNVSSIKVGDHVIPD-------------------------------------------------GLGTWRELGLHQENDLFPIDNTLSMEYAATFQVNPPTAYRMLKDFIDLKKGDTVAQNGASAVGKHVIQICRILGIKTVNVVDNLEELVKELKDLGADEVITQEE------LYSRKKKFPGVKLALNCVGGRSS--LFLASLLDHGGCMVTYGGMSKQPVDCPTGPLIFKDISLRGFWMSRWYDHEMYQELAGWMKSGEIKKQ--EIVKNRLEDHAKALDTALSKFDKKQFFVL 343
10 -36.100[CR] COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases  ali follow..  14  1.........MQALLLEQQDGKASVQTLDESRLPEGDVTVDVHWSSLNYKDALAITGKGKINFPMIPGIDFAGTVRTSE--DPRFHAGQEVLLT------------------------GWGVGENHWG------------------GLAEQARVKGDWLVAMPQGLDARKAMIIGTAGFTAMLCVEDAGVRPQDGEIVVTGAGGVGSTAVALLHKLGY-QVVAVSGRESTHEYLKSLGASRILPRDE-----FAESRPLEKQVWAGAIDTVGDKVL--AKVLAQMNYGGCVAACGLAGGFTLPTTVMPFILRNVRLQGVDSVMTPPERRAQAWQRLVADLPESFYTQAAKEISLSEAPNFAEAIINNQIQGRTLV. 321
11 -19.600[R] COG2130 Putative NADP-dependent oxidoreductases  ali follow..  19  1MSNTYQRIVLASRPEGAVTDNFRLETAQIPELQDGQVLVRNHFLSLDPYMRGRMNDSKSYAQPQPLGEIGGTVGVVEASRNPAYAVGDNVV---------------------------------------------------GMFGWQEVGISDGRGMQKVDTRHLSAYLGSVGMPGVTAWYGLNRIMHPKPGQTVAVSAAGAVGSVVGQLAKLKGC-RAVGFAGGKDKCDVVNELGFDACIDAAKDPKELYAMLKEATPDGIDAYFENVG--GDILDAVLRRMNPFGRIAMCGMIAGYDGQPLPLLILVSRLTVEGFIVSEHMDVEALRELGGSVAQGKLKFRESVAQ--GLASAPEAFIGLLKGKNFGKQLV. 333
12 -16.100[R] KOG1196 Predicted NAD-dependent oxidoreductase  ali follow..  15  22...................SDLVITSTTIDLKGSMTALVKNLYLSC--RKPDPLSPATAQSFTPGKPISGFGVSKVIDSGHSDYEEGDLIW---------------------------------------------------GAVGWEEYSVITPIPNLHFHTNFPLSYTGLLGMPGMTAYVGFYEICTPKKGDTVFVSAAGAVGQLVGQFAKLMGC-YVVGSAGSKEKVDLKNKFGFDDAFNYKE-EHNLIGALKRCFPEGIDIYFENVG--GKMLDAVILNMRPHGRIAACGMLKNPEGIYGLSLITYKRIRIEGFNCFDYFHKEFLEFVVPYIKEGKIKYVEDVAD--GLESAPAALVGLFHGKNVGKQLV. 341
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Topczewski J, Godzik A., Paszewski A. The Aspergillus nidulans cysA gene encodes a novel type of serine O-acetyltransferase which is homologous to homoserine O-acetyltransferases. Microbiology. 2000 Oct;146 ( Pt 10):2695-703.