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Query: [AR] KOG0109 RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPRGPAAPRPPAGPAASMGRCAPNAGSGPEAERSAAPSAGPPGPPLRPLGADPCVSPGSDPASPSSRPASRAQALRGPPKSRSPARLAARPQQPSAQKGHAAHGRVVGFGCAEREVPESAVARLCPRGCLRGAVPFLPRPRGPELLAGSEISADPVICCPRGSGLATPRTLSGKWLTDEGRASSGCLNPNRCKPAPHAEGVGAGSRGGARAQSVLSPSGDSREGDLLQFASSERARLTPMIPRPRLLRIHGAFRTKRFSVRDKEDQWTVSVQRQLVYRPSTEAGHNNKELPPPLPPRGACPDDEAVHQKPAPGGHRAGDPLSFQAVGKVLECDIIKNYGFVHIEDKTAAEDTIHNLHHYKLHGVNINVEASKNKSKASTKLHVGNISPTCTNQELQAKFEKYGPVIECDIVKDYVLIHFIHMECCPQARLRTAPGMGDQCGCYQCKKEGHWSKECPVDRTGRVADFTEQCNEQYAAVHTPYTMGYGESRYYNDAYAALHYYKRYWLLWLPLRPPLPPIVEPRHAAAMLPTVGEGYGYGPESELFQASAATRNSLHDMARYEREHYMDRACFSMAQATVIEPAVGGATGQVRVLHCTTHAEENHLSWWNLEKGWRDLSELDSSVEEMLQLMDSGITICLRNGAASVFKKKEWSTQGEENKQDRNGPVTQADHPIPLDLEIEQGVKIIPTPTSKEGQLAIYEEIDTDLFWYLKLLast
1 -246.000[AR] KOG0109 RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains  ali  100  1MPRGPAAPRPPAGPAASMGRCAPNAGSGPEAERSAAPSAGPPGPPLRPLGADPCVSPGSDPASPSSRPASRAQALRGPPKSRSPARLAARPQQPSAQKGHAAHGRVVGFGCAEREVPESAVARLCPRGCLRGAVPFLPRPRGPELLAGSEISADPVICCPRGSGLATPRTLSGKWLTDEGRASSGCLNPNRCKPAPHAEGVGAGSRGGARAQSVLSPSGDSREGDLLQFASSERARLTPMIPRPRLLRIHGAFRTKRFSVRDKEDQWTVSVQRQLVYRPSTEAGHNNKELPPPLPPRGACPDDEAVHQKPAPGGHRAGDPLSFQAVGKVLECDIIKNYGFVHIEDKTAAEDTIHNLHHYKLHGVNINVEASKNKSKASTKLHVGNISPTCTNQELQAKFEKYGPVIECDIVKDYVLIHFIHMECCPQARLRTAPGMGDQCGCYQCKKEGHWSKECPVDRTGRVADFTEQCNEQYAAVHTPYTMGYGESRYYNDAYAALHYYKRYWLLWLPLRPPLPPIVEPRHAAAMLPTVGEGYGYGPESELFQASAATRNSLHDMARYEREHYMDRACFSMAQATVIEPAVGGATGQVRVLHCTTHAEENHLSWWNLEKGWRDLSELDSSVEEMLQLMDSGITICLRNGAASVFKKKEWSTQGEENKQDRNGPVTQADHPIPLDLEIEQGVKIIPTPTSKEGQLAIYEEIDTDLFWYLKL 712
2 -42.500[AJ] KOG0123 Polyadenylate-binding protein (RRM superfamily)  ali follow..  11  2....................................................................................................................................................................................................NAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGP----VLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWS----QRDPSLRKSGVGNVFIKNLDKS-IDNKALYDTFSAFGNILSCKVVKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKERETNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMKGFGFVSYEKHEDANKAVEEMNGKEISGKIIFVGRAQKKVERQAELKRKFEQLKQERI-----------------------------------------------------------------------------------------------------------------------------SRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAK-----VMLEDGRSKGFGFVCFSSPEEATKTEMNGRIVGSK-----PLYVALAQR----KEERKAHLT............... 379
3 -41.900[A] KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily)  ali follow..  10  17.....................................................................................................................................................................................................................GSEPAAAAAVVAAGDKWKPPQGTDSIKMENGQSTAAKLGLPPLTPEQQEALQKAKKYAMEQSIKSVLVKQTIAHQQQQAQRQRALAIMCRVYVGSIYYE-LGEDTIRQAFAPFGPIKSIDMSKGFAFVEYEVPEAAQLALEQMNSVMLGGRNIKVGRPSNIGQAQNRIYVASVHQDLSDDDIKSVFEAFGKIKSCTLAKGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGKAVTPPMPLLTPATPGGLPPAAAVAAAAATAKITAQEAVAGAAVLGTLGTPGLVSPALTLAQPLGTLPQAVMAAQAPGVITGVTPARPPIPVTIPSVGVVNPILASPPTLGLLEPKKEKEEEELFPESERPEMLSEQEHMSISGSSARHMVMQKLLRVDPKDIDDDLEGEVTEECGKFGAVNRVIYQEKQGEEEDAEIIVKIFVEFSIASETHKQALNG----AGRKV---------AEVYDQERFDNSDLS............... 558
4 -39.100[A] KOG0145 RNA-binding protein ELAV/HU (RRM superfamily)  ali follow..  13  5..............................................................................................................................................................................................................................................................ISTMEPQVSNGPTSNTSNGPSSNNRNCPSPMQT------GATTDDSKTNLIVNYLPQN-MTQEEFRSLFGSIGEIESCKLVLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKSSQALLS----------------------------------------------------------------QLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRLMSGPVPPSACSPRFSPITIDGMTSLVGMNIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNIRDF------NTNKCKGFGFVTMTNYDEAAMASLNGYRLG-DRVL---------VSFKTNKAHKS................... 380
5 -38.900[A] KOG0115 RNA-binding protein p54nrb (RRM superfamily)  ali follow..  13  56....................................................................................................................................................................................................................................................NRGGAERGIAPAQQPYDNNGGHRSGGGGGRSGGGGTSFNGAAFTESQLVPKKKFTGRCRLFVGNLPNE-VKETELKELFSPHGDIAECYLSKGFAFLRLDTRAHAESAKEAIDGRIIHGRQVRVRFAVHG----AAIRVKELSPTVSNEMLYHAFSHFGDVERAVHITGEGIVEFERKPNCNEAMAAIRDKVFSPKPLICEVLEPRDEDD.................................................................................................................................................................................................................................................................. 275
6 -37.700[A] KOG0146 RNA-binding protein ETR-3 (RRM superfamily)  ali follow..  11  2..............................................................................................................................................................................................................................................................YIKMATLANGQLSTNGLGSSPGSAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQIPRN-LDEKDLKPLFEEFGKIYELTVLKGCAFLTYCERESALKAQSALHEQKTLPRPIQVKPADSESRQDRKLFVGMLNKQQSEDDVRRLFEAFGNIEECTILKGCAFVKYSSHAEAQAAINALHGSQGASSSLVVKFADTDKERTMRRMQQMAGQMGMFNPMAIPFGAYGAYAQALMQQQAALMASVAQGGYLNPMAAFAAAQMQQMAALNMNGLAAAPMTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQPAAEAVFANGIHPYPAQSPTAADPLQQAYAGVQQYAGPAAYPAAYGQIREGPEGCNLFIYHLPQEFGDAELMQMFLPFGFVSFDNPASAQTQAMNGFQIGMK---RLKVQLKR-----PKDANRP-----Y............. 486
7 -37.300[A] KOG0144 RNA-binding protein CUGBP1/BRUNO (RRM superfamily)  ali follow..  13  2...............................................................................................................................................................................................................................................................................................NGTLDHPDQPDLDAIKMFVGQVPRT-WSEKDLRELFEQYGAVYEINVLKGCCFVTFYTRKAALEAQNALHNMKVLPGMHHPDSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGCAFVTFTTRAMAQTAIKAMHQAQGCSSPMVVKFADTQKDKEQKRMAQQLQQQMQQISAASVWGNLAGLNTLGPQYLALLQQTASSGNLNTLSSLHPMGGLNAMQLQNLAALAAAASAAQNTPSGTNALTTSSSPLSVLTSSGSSPSSSSSNSVNPIASLGALQTLAGATAGLNVGSLA--KEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSFIDK------QTNLSKCFGFVSYDNPVSAQAQSMNGFQIG-MKRL---------VQLKRSKNDSK-----Y............. 482
8 -35.500[R] KOG0110 RNA-binding protein (RRM superfamily)  ali follow..  8  205................................................................................................................................................................EEDTDKLAEKPISDLEYMKSLMATTSGEATAKKPKAKADKSNLELFTIKIHNVPYNTKRQEVLKFFKPLKP----------YSVRLPSKVHGFCYVGFKTEKDMAKGMLKNKSFIKGKQVFNAKWKHQQDSLSKEDDISESGRIFFRNLAYT-TTEEDLRKLFEQFGPVVEVNLPKGFGTVTYMMPEHALKAFNTLDGTDFHGRLLHLLPSKDIEKSNTVILAKNLPAATEISEITPIFSRFGPIGRIVLSGVTALIEYCDPLEARQAFKKLAYSKFKNAPLYLEWAPEQVFTKTLSGEPVIPKSEPKPKEEVKPEEKPIVNDAKPDEEDSRAEDADDEPEPNTT-NFKTVQETVEKHFRHLGSIHTVEIAKRRDPENPREFKSLGYGFSSVAEHALKNLQLTHIDGNPVELKRSDRVLKTQDNDGAQRRLASQKKQTGTKILVRNIPFQAQYREVRDIFKAFGELLRIPKKATT---GEDAHRGFGFVDYMSKAEAKRDALSASTHLYGRRLVLEWSANDDNQDVEELRKRTAAKFD.............. 884
9 -35.000[R] KOG4733 FOG: RRM domain  ali follow..  13  3...............................................................................................................................................................................................................................................KVWKQQMYPQYATYYYPQYLQAKQSLVPAHPMAPPSPSTTSSNNNSSS---SSNSGWDQLSKTNLYIRGLPPH-TTDQDLVKLCQPYGKIVSTKAIKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDP-----TNLYISNLPLSMDEQELENMLKPFGQVISTRILRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKR.......................................................................................................................................................................................................................................................... 231
10 -34.700[AJ] KOG0148 Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily)  ali follow..  12  5...........................................................................................................................................................................................................MPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMI------MDTAGNDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATT--PSSQKKDTSNHFHVFVGDLSPQ-ITTEDIKAAFAPFGRISDARVVKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPANCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIG........................................................................................................................................................................................................................................................ 290
11 -34.400[A] KOG0131 Splicing factor 3b, subunit 4  ali follow..  17  10..............................................................................................................................................................................................................................................................................................GANLLGQHSAERNQDATVYVGGLDAQ-LSEELLWELFVQAGPVVNVYVPQNYGFIEYRSEEDADYAIKVLNMIKLHGKPIRVNKASQDKKSLANLFIGNLDPDVDEKLLYDTFSAFGVIASNPKIRGFGFISYDSFEASDAAIESMTGQYLSNRQITVSYAYKKDTKGERHGTPAE.......................................................................................................................................................................................................................................................... 204
12 -32.900[K] KOG0147 Transcriptional coactivator CAPER (RRM superfamily)  ali follow..  17  21.....................................................................................................................................................................EEDEQQRKEVKKDYPSNTTSSTSNSGNETSGSSTIGETSNRSRDRDRYRRRNSRSRSPGRQCRHRSRSWDRRHGSESRSRDHRREDRVHYRSPPLATGYRYGHSK-------SPHFREKSPVREPVDNLSPEERDARTVFCMQLAAR-IRPRDLEDFFSAVGKVRDVRIIKGIAYVEFCEIQSVPLAIG-LTGQRLLGVPIIVQASQAEKNRLMRLYVGSLHFNITEDMLRGIFEPFGKIDNIVLMKGYGFITFSDSECARRALEQLNGFELAGRPMRVGHVTERLDGGTD................................................................................................................................................................................................................................................................ 332
13 -32.700[A] KOG0105 Alternative splicing factor ASF/SF2 (RRM superfamily)  ali follow..  14  2.................................................................................................................................................................................................................................................................................................SGWADERGGEGDGRIYVGNLPTD-VREKDLEDLFYKYGRIREIELKNPFAFVRFEDPRDAEDAIYGRNGYDYGQCRLRVEFPRTYGGRGGRVLVSGLPPSGSWQDLKDHMREAGDVCYADVKDGVGMVEYLRKEDMEYALRKLDDTKFRSHEGETSYIRVYPERSTSYGYSRSRSGSRGRDSPYQSRGSPHY....................................................................................................................................................................................................................................... 214
14 -32.400[D] KOG4660 Protein Mei2, essential for commitment to meiosis, and related proteins  ali follow..  10  2................................................................................ELEPNKSLS-ADMPSLLSRSSEA---FNGGTGYRSSSDLSMFSSSLPTLFHEKLNMTDSDSWLSFDESSPNLNKLVIGNSEKDSLEDVE-----------------------------------------PDALEILLPEDENELLPGLIDELNFTGLPDELDDLEECDVFCTGGGMELDVESQDNHAVDASGMQISDRGAANAFVPRKRPNTAPNGEHPSRTLFVRNINSS-VEDSELSALFEPFGEIRSLYTARGFVMISYYDIRAAHAAMRALQNTLLRKRTLDIHFSIPKENNQGTLVIFNVDTTVSNDELLQLFGAYGEIREIRETRFHRFIEYYDVRDAETALKALNRSEIGGKCIKLELSRPGGARRLSVPSQSQDLERTEVTNFYNQVGSHVANSPPGNWPIGSPVKGSPSHAFTRPHGLGMVRPVNSDNMPGLASILPAHPSSFHGFSPVSNDQGLLNHSNQTILNKGLMHNISYGQPHSLPEHITGGISNSMRFIAPHSSGFGTSSDHRYRWGSPPQHMNYPGYT-NSSEQDFTGFGMSSMPTVPFGGSRGLQSVRPEPFAEQGRIHNHESHNQNQFIDGGRYHIDLDIASGIKNIPNKYTYKMLVAEIDEYD---FLCLPT 702
15 -31.400[A] KOG4212 RNA-binding protein hnRNP-M  ali follow..  11  1...............................................................................................................................................................................................................................................................MAAGVEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEYANPTKRYRAFITNIPFD-VKWQSLKDLVEKVGEVTYVELLRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPEERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMELERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYA------IKMENGKSKGCGVVKFESPEVAERRMMNGMKLSG----EIDVRIDR............................... 728
16 -30.600[A] KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily)  ali follow..  12  2.....................................................................................................................................................................................................................................................ESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGG--PPPGWDAAPPERGCEIFIGKLPRD-LFEDELIPLCEKIGKIYEMRMMRGYAFVTFSNKVEAKNAIKQLNNYEIRNGRLLGVCASVD---NCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVRGFAFVEYESHRAAAMARRKLLPGRIQGHGIAVDWAEPEVEVDE------------------------------------------------------------------------------------------------------------------------------------------DTMSSVKILYVRNLMLSTSEEMIEKEFNNIKPG---------AVERVKKIRDYAFVHFSNREDAVEKALNGKVLDGS-----PIEVTLA-----KPVDKD................... 307
17 -29.300[A] KOG0128 RNA-binding protein SART3 (RRM superfamily)  ali follow..  11  550..................................................................................................................................................................................................................................................................GFKAPLPPSNAKSSSAVSSSNASSTPAPGSFAVQKAAPGTEDARTIFVSNLDFT-TTEDEIRQAIEGVASIRFARKARGFAYVVMENDQKAQQALL-KDRVPVKGRPMFISANDPEKREKSKVFVRNVHFQATDDELKALFSKFGTVTSVRRVKGIAFVDFDTEASAQKCVASGDKLMLRERELEVALSNPPVKKDKSHGKPAAIGASLEE................................................................................................................................................................................................................................................... 780
18 -28.600[R] KOG0118 FOG: RRM domain  ali follow..  10  1......................................................................................................................MAVVETGAAATAADAGGVVIQPPP------------------SSPPSSMTSQDSGVSSDDQNHHSRIDQVLRHDQGLYSKIGSHVARSDGVDGGESFKRDMRELQELFSKLNPMAEEFVPPSLNKQGGNGTSAGSFFRNNGFAGTGNGGYGNENGGFRRKKSFGQGKRRMNARTSMAQREDVRRTVYVSDLDQQ-VTEEQLAGLFVSCGQVVDCRICLRFAFIEFTDEEGAMTALN-LSGTMLGFYPVKVLPSKTAIAPARTIYCTNIDKKVTQSDVKIFFESFCGEVYRLRLTRIAFVEFVMAESAIAAL-NCSGVVLGSLPIRVSPSKTPVRPRSPRHP............................................................................................................................................................................................................................................................. 356
19 -27.700[K] KOG4210 Nuclear localization sequence binding protein  ali follow..  14  82..................................................................................................................................................................................................................................................................EDAEKKKSGASEKDAQGEESTINTPTGDESGEVVKKKKKDENKYGVWIGNLSFD-TTKDDLVRFFIAKTKDNEDEK-KGFCYMFFKNVEQMKAVLE-LSESHLNGRNMLIKDSENYSGRSRILFVGNLSFDVTDDLLRKHFQHCGDIVKIRMAKGFAFIDFKNEEGSTNELKDKSCRKIAGRPLRMEYGEDRSKRQVRKKVENVSRN....................................................................................................................................................................................................................................................... 333
20 -26.700[A] KOG4206 Spliceosomal protein snRNP-U1A/U2B  ali follow..  13  2.....................................................................................................................................................................................................................................................................................................LTADIPPNQSIYIQNLNERIKKEELLYCLFSQFGRILDVVALRGQAWVTFSEVTAAGHAVRQMQNFPFYDKPMRLQYAKAKSDPNNILFIQNLPHETTSMMLQLLFEQYPGFKEIRMIPGIAFVEYEDDVQASIAMQPLQGFKITPQNPMVISFAKK...................................................................................................................................................................................................................................................................... 232
21 -26.700[A] KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily)  ali follow..  15  2.............................................................................................................................................................................................................................................................................................................VRVYIGRLPNR-ASDRDVEHFFRGYGKLSDVIMKNGFGFVDFQDQRDADDAVHDLNGKELCGERVILEFPRRKVSTRFRLVIDNLSTRYSWQDIKDHIRKLGIEPTYSEAVNQAIVCFTSHDDLRDAMNKLQGEDLNGRKLKCTDETRDRSRSRSPRRRSRSRSPTRSRSPPARRRSPG........................................................................................................................................................................................................................................ 217
22 -26.700[J] KOG0899 Mitochondrial/chloroplast ribosomal protein S19  ali follow..  10  2............................................................................................................................................................................................................................................ESRHFATALVFLASKGFVDILYWVYRFQASSMAFCTKL----GGHWKQGVNVPVSSMLGSLRYMSTKLYIGGLSPG-TDEHSLKDAFSSFNGVTEARVMRGYGFVNFISEDSANSAISAMNGQELNGFNISVNVAKDWPSLPLSFVDAFLMKKKNAALNRKIWSRRSTILPEYVYNGKTHVRCKITEGKVGHKFG......................................................................................................................................................................................................................................................................................... 229
23 -26.400[A] KOG1190 Polypyrimidine tract-binding protein  ali follow..  11  9....................................................................................................................................................................................................................................................................AVGTKRGSDELFSTCVTNGPFIMSSNSKKFKGDSRSAGVPSRVIHIRKLPID-VTEGEVISLGLPFGKVTNLLMLKNQAFIEMNTEEAANTMVNYYTSVTPRGQPIYIQFSNHKELKTDSIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTKQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTRPDLPSGDSQPSLDQTMAAAFASPYAGAGFPPTFAIPQAAGLSVPNVHGALAPLAIPSAAAAAAAAGRIAIPGLAGAGNSVLFNKKENALVQMADGNQAQLAMSHLNGHKLHGKPIRITLSKHQNVQLPREGQEDHLSNIPPSVSEEDLKVLFSSNGGVVKGF-----KFFQKDRKMAL--IQMGSVEEAVQ------LIDLHN-----HDLGENLRV-----SKS................... 548
24 -26.100[A] KOG0120 Splicing factor U2AF, large subunit (RRM superfamily)  ali follow..  9  77.............................................................................................................................................................................................................................................................................................PQTAVPVVGSTITRQARRLYVGNIPFG-VTEEEMMEFFNQQMHLVGLAQAKNFAFLEFRSIDETTQAM-AFDGINLKGQSLKIRRPHDYQPSPHKIFIGGLPNYLNDDQVKELLLSFGKLRAFNLVKGYAFCEYVDLSITDQSIAGLNGMQLGDKKLIVQRASVGAKNAQNAA------------------------------------------------------------------------------------------------------------NTTQSVMLQVPGLSNVVTSGPPTEVLCLLNMVTPDELRDEEEYEDILEDIKEECTKYGVVRSVIPRPIEGVEVPGCGKVF--VEFNSVLDCQKQALTG----SDRVV---------TSYFDPDKYHRREF................ 416
25 -25.200[R] KOG0125 Ataxin 2-binding protein (RRM superfamily)  ali follow..  14  44..........................................................................................................................................................................................................................................VPHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTKRLHVSNIPFR-FRDPDLRQMFGQFGKILDVEIIKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKK............................................................................................................................................................................................................................................................................................................................................ 195
26 -24.600[A] KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1  ali follow..  14  3...............................................................................................................................................................................................................................................................TTVSTGATAVATLRE-TSPPVDGHEEAR---LNADSDDGSHGSQDPGKMFIGGLSWQ-TTAENLRDYFGRFGEVNECMVMRGFGFITFVDPSSVDKVLNN-REHELDGKKIDPKVAFPKRTKTKKVFIGGLSATSTLEDMKQYFETYGKVEDAMLMRGFGFVTFDSDEVADKVCEI-HFHEINGKMVECKKAQPKEVMLPVQLNKSRAAA....................................................................................................................................................................................................................................................... 227
27 -24.000[R] KOG0226 RNA-binding proteins  ali follow..  11  109.........................................................................................................................................................................................................................................................................................................................AAPIMFPPRVLGIPAPATIEGAPNAIPQELLRTQALQSDIDKMNFKKQTDPFKKKIKEQQAKKKDFRVFCGDLGNEVSDELLAKAFRKYPSFQKAKVVKGYGFVSFRDSEDYVRAMREMDGKYVGNRPIKLRKSAWKERNIDVIKQKRKQKK....................................................................................................................................................................................................................................................... 297
28 -22.800[A] KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins  ali follow..  10  4......................................................................................................................................................................................................................................................................................................GTEGGEGFVVKVRGLPWS-CSADEVQRFFSDCKIQNGAQGISGEAFVELESEDEVKLALKK-DRETMGHRYVEVFKSNNVTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGITLTGEAFVQFASQEIAEKALKK-HKERIGHRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGY--------------------------------------------------NSIGRGAGFERMRRGAYGGGYGGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSTFQSTTGHCVHMRGLPYRATENDIYNFFSPLN-----PVRVHIEIGPDGRVTGEADVEFATHEDAVAAMSKDKANMQHRYVELFLNSTAGAS............................ 368
29 -22.700[AR] KOG1365 RNA-binding protein Fusilli, contains RRM domain  ali follow..  8  28..................................................................................................................................................................SFYPRRQEDANNNSTSPSSASSSGSEISTRLVNITPEDVVKFFDEHPTSSYIFTKGPEPIRHVLIPLFARNELCVPHPLHH-YGNQEEDGMEQEEIEDDVAIARAILDMDDELLEKTHQFVNQPAPILEDQEVGADGDNVVCRARGLPWQ-ASDHHVAQFFAGLDIVPGGIALNGEVLVQFSSQESRDLALK-RHRNFLLSRYIEVYKAGLDEANAIIVRMRGLPYDCTDAQIRTFFEPLKLTDKILFITGDAFVQFETEEDAQQGLLK-HRQVIGQRYIELFKSTAAEVQQVVKRCNLINSSPAVANAVEAPEEKKPYEATVQHIVTFLGDFATMVKFQGVHMVYNNQGHPSGEAFIQMINEQAASACSVGKKKRYIEVFQASAEELNLHHLVGQQHQVPPPAPLGFMGQLPPQAPQPQQFWSSYPSPPISPIVPGQVTIIYGIHMSIGVPELVANFTTPEHT---VDNVLFTRWPTHLCPGEAILTLRNRGAPPPSPLSQPQNFPLQPILME.................................... 614
30 -22.500[A] KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily)  ali follow..  13  12...........................................................................................................................................................................................................................................................................................DQHFKGSRSEQERSLRDSCTLYVGNLSFY-TTEEQIHELFSRCGDVRVIVMGCGFCFVEYYVRSEAEAAMRFVNGTRLDDRLIRVDWDAGFVEGRQRGKTGGQVRDEYRTDYDAGRGGYGKLLSQKIAPN........................................................................................................................................................................................................................................................................................................... 150
31 -19.500[A] KOG4209 Splicing factor RNPS1, SR protein superfamily  ali follow..  14  29...............................................................................................................................................................................................................................................................GDLNEIEEEQKKLKAIQNEMVGHMNLNTSSQSNSSQTPEEKAEADAKSVYVGNVDYG-ATAEEIEQHFHGCGSVSRVTIQKGFAYVEFTEKEGMQNAL-AMTDSLLRGRQIKVDPKRTNKPGVKYVYAGGFRPRGRGARRRPGFAPY...................................................................................................................................................................................................................................................................................................................... 205
32 -19.500[K] KOG1548 Transcription elongation factor TAT-SF1  ali follow..  10  45.......................................................................................................................................................................................................................................................KAGSTGAEVSDVTAEATEGKESYESTSAEGYPSGSRNKKSKSENSEASPAPVINKAVYIQGLPLD-VTVDEIEEVFKKCGVIAKNIDNKGDALIVFFRSESVELAEQLFDDTEFRYGSGQKMRVQKANIDYKKVVLKHI--IDLKDDITEEAEKCGRVTNVVLPDGVVTVRFSNNEEAEACVRLMQGRYFDGRVVEASIYDGKVRFQKSGKHTLDDEEDEEKRLEKFAD............................................................................................................................................................................................................................................ 361
33 -19.400[J] KOG0122 Translation initiation factor 3, subunit g (eIF-3g)  ali follow..  10  118......................................................................................................................................................................................................................................................................................................................ESKATGDGLSQLGKGGAVLMVCRICSKCPYKDLAAPTDVFIDKPPTGESSTMSAAPGTGKAARRRNDENSVRVTNLSEDTREPDLMELFHPFGAVTRVYVARGFGFVNFVSREDAQRAINKLNGYGYDNLILRVEWATPRPT.................................................................................................................................................................................................................................................................... 294
34 -19.100[A] KOG0108 mRNA cleavage and polyadenylation factor I complex, subunit RNA15  ali follow..  20  2........................................................................................................................................................................................................................................................................................................SMTAGNVVFVGNIPYD-VSEQQMTEIFNQVGPVKTFKLVKGYGFCEFFDSETTAMAVRKLNNSELGPRKIRVEFPSNDPRRNQS............................................................................................................................................................................................................................................................................................................................................ 92
35 -19.000[A] KOG4207 Predicted splicing factor, SR protein superfamily  ali follow..  15  2.................................................................................................................................................................................................................................................................................................SCGRPPPDVDGMITLKVDNLTYR-TSPDSLRRVFEKYGRVGDVYIPRGFAFVRFHDRSDAQDAEAAMDGAVLDERELRVRMARYGRRDLPR............................................................................................................................................................................................................................................................................................................................................ 99
36 -18.800[A] KOG0107 Alternative splicing factor SRp20/9G8 (RRM superfamily)  ali follow..  13  2.............................................................................................................................................................................................................................................................................................................SRVYVGNLDPR-VTERELEDEFRSFGVIRSVWVARGYAFLDFEDSRDARDAIREVDGKNGWRVEQSHNRGGGGGRGGGR............................................................................................................................................................................................................................................................................................................................................ 82
37 -18.200[R] KOG4454 RNA binding protein (RRM superfamily)  ali follow..  12  1.................................................................................................................................................................................................................................................................................................MEIKPTPSPPEERTIYVANFSEE-VDEELLEELFIQAGPVVKVILRAKFALVEFEDELSVLFAIELMNGVRLFNQELQVKPRNGTNQEE.............................................................................................................................................................................................................................................................................................................................................. 94
38 -17.800[R] COG0724 RNA-binding proteins (RRM domain)  ali follow..  12  173...........................................................................................................................................................................................................................................................................................ARDPSSDAYRDSRERDDMCTLKIMQVNENADENSLREELLFPFAPIPRVSVVRGLAFVTFSSEEVAEQALRFLDGRGYMNLILRVEWSKPKVKE............................................................................................................................................................................................................................................................................................................................................... 274
39 -17.400[J] KOG0129 Predicted RNA-binding protein (RRM superfamily)  ali follow..  12  132.KIRIESPVLTG-ATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSSTIINEDA--SFFHQGGVPAASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRNAAFNQLPHLANNLNKPPSSYQSPSPTPSSSWSPGGGGYGGWGGSQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDTEDGFLDDGRGDQPLHSGLGSPHCFSHQNGERVERYSRKVFVGGLPPD-IDEDEITASFRRFGPLIVDWPHKGYAFLLFQDESSVQALIDA---EEDGKLYLCVSSPTIKDKPRKTIFVGGVPRPLRAVELAMIMDRYGGVCYAGIDKGAGRVAFSNQQSYIAAISA......................................................................................................................................................................................................................................................................................... 624
40 -17.300[R] KOG0149 Predicted RNA-binding protein SEB4 (RRM superfamily)  ali follow..  14  2.......................................................................................................................................................................................................................................................................................AYQPVPGSGFHYLNSPFGDTTFTKVFVGGLAWE-TQSETLRQHFEQYGEILEAVVIKGYGFVTFRDPEAARRACAD-PTPIIDGRRANCNLASLGRPRPPVIPNMPDLLPRTLEMCRVLEVHLLEIIR................................................................................................................................................................................................................................................................................................................. 139
41 -17.000[R] KOG0130 RNA-binding protein RBM8/Tsunagi (RRM superfamily)  ali follow..  17  57.............................................................................................................................................................................................................................................................................................EDDDELEPGPQRSVEGWILFVTSIHEE-AQEDEIQEKFCDYGEIKNIHLNKGYALVEYETHKQALAAKEALNGAEIMGQTIQVDWCFVKGPKRVK............................................................................................................................................................................................................................................................................................................................................ 158
42 -16.300[R] KOG0114 Predicted RNA-binding protein (RRM superfamily)  ali follow..  11  1...............................................................................................................................................................................................................................................................................................MNKRNHIRLPPEVNRLLYVRNLPYK-ITSDEMYDIFGKFGAIRQIRVGRGTAFVVYEDIFDAKNACDHLSGFNVCNRYLVVLYYQSNKAFKRV............................................................................................................................................................................................................................................................................................................................................ 97
43 -16.200[R] KOG0126 Predicted RNA-binding protein (RRM superfamily)  ali follow..  10  2........................................................................................................................................................................................................................................................................................................................................................NPLTKVKLINELNEREVQLGVADKVSWHSEYKDSAWIFLGGLPYELTEGDIICVFSQYGEIVNINLVKGFCFLCYEDQRSTILAVDNFNGIKIKGRTIRVDHVSNYRAPKDSEEIDDVTRQLQEKGCGARTPSPSLSESSEDEKPTKKHKKDKKEKKKKKKEKEKADREVQAEQPSSSSPRRKTVKEKDDTGPKKHSSKNSERAQKSEPREGQKLPKSRTAYSGGAEDLERELKKEKPKHEHKSSSRREAREEKTRIRDRGRLQMHILAGIMGVLKGVVIE-------------VGAEINPIGIKGPDAPGRGVLRIPVTVGVTEDFSCTVDLEI------IMFFKCSQIQLGGY---------YFCI 351
44 -15.900[R] KOG1457 RNA binding protein (contains RRM repeats)  ali follow..  11  18...............................................................................................................................................................................................................................................................................................................................................SGAGSGGALEEEPQNLGFGRGQSCELEAGIHRGIIQLKTRPGVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLIKQPVGFVIFDSRAGAEAAKNALNGIRFDPENPQTLRLE---AKANTKMAKSKLMATPNPSNAWAPYPLYTTELTPAISHAAFTYPTATAAAAALHAQRRHIRQCTPTCRIEKLMLKGLVTGEVVLVTAPRLTPSPESQSCTGRLGSKMSVLVNASAGDPGALREEEEEPGQDQALQMEKVKHRGVSKRSVLLLSLGIAQSLPYLRVDHPPDPAQRLCQRPSSPFTAFCQPTSSPVRKRAAWGSQGEGDAAIINEPGTE----LR------------PLNDSEQIRRVEGEEIS-------K. 414
45 -15.100[R] KOG4208 Nucleolar RNA-binding protein NIFK  ali follow..  12  2........................................................................................................................................................................................................................................................................................................AAFSRSAGPILSLN---QEDAELQKEVAQCDTVTRFRLSKGYAFVEFESEDVAKIVTETMNSYLFGERLLECHFMPPEKKMES............................................................................................................................................................................................................................................................................................................................................. 90
46 -15.000[D] KOG2186 Cell growth-regulating nucleolar protein  ali follow..  11  10...GENLKKPRL--PRHMSMCTATKFS--EAEKYGPMVRS---NGESSKQKHDFDINAELFNSQMTCEQDYFAHVYGKKHQEKANEVADMDYSKQQSEHPAVDKN-----------NLTQQPDLDIYVGLSNDYPWFCSLCDINATSEQTLLAH------GKKHRVKVERFDAEQQKRQSTQHSTVDKKDYSKQQIEVDINVGLSNCYPWFCSLCNVKATCQQNLLSHANGRKHRENVELFDATQQQQLEKTTVDKKDTTVNASDGNSEQKKVDLLVSSGVANGYSQAHKKRKLETCDETWKREVVQAEEAKGGGEQKSESKKAKKQDKEKKRKKDSDFEHDKEDIKQLLVAYSKEELVNLIYKTAAILESADRDIAQRNIFVRGFGWDTTQENLKTAFESYGEIEECSVVKGYGFVMFKTRKGAREALKRPEK-RMYNRIVVCNLASEKPGKAGKEQDMAEPVNIDLTKMANQSEAVLPGIELGRGHVLEKMHHQQQQTMDMFGQNMPFYGYSHQFPGFDPMYGALSGNQMLAGLPNYDLNFDNRKTKKMVWFQCEEMFGRDTVQGHNQCITEAEKYGPKGQSKSANGTPAKPKDISKQEPDFDI-GLSNRYPWFCSLCNTKATSQQTLLAHADGKKHRGKAKAFDLKKAKKQDHEKKINWKKLITSADKTLKMK-KLKKLVSIVDSGRDKSELKAELELVDGK---YVKL 845
47 -14.800[R] KOG0153 Predicted RNA-binding protein (RRM superfamily)  ali follow..  10  1.................MSKTTNTY------NRQNWEDAEFP--------CQTCL--GDNP-------VRMIKERFG-----KECKICTRP-CPGARM----------------RFKKTEICQTCARLKNVCQTCLLDLEYGLPIQVRDAALKVADNMPQSDVNKEYYIQNIDAQLQDGDGTEAAGAVGRSLAANEMLSKLARTAPYYKRNR--------------------------------PHICSFWVKGECKRGEECPYRHDKPNEPDDPLCEQNIKDRYYGRNDPTLEPPEDRNITTLYVGNLPEE-ITEPELRDQFYQFGEIRSIALVQQCAFVQYTKRNAAELAAERTNKLVIQGRKVSIKWAHSQAKQGTA............................................................................................................................................................................................................................................................................................................................................ 310
48 -13.100[K] KOG4661 Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B)  ali follow..  22  363..................................................................................................................................................................................................................................................................NEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSST-TRATDLKNLFSKYGKVVGAKVVRCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPVGKKT............................................................................................................................................................................................................................................................................................................................................ 491
49 -13.100[R] KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains  ali follow..  13  206...........................................................................................................................................................................................................................................................................................SNLSNNDRYSDWNPGVPSNKLAILNMPND-VDNTKITLSLGKCGYLPQTKQIRTFAFVEFSNRETAEQWMTDYEGWLTDGRTLAVEYAKGDPAAGSGLLIRGLPDGINNSLIFDSLGALVCLSSISMIKRFAYLQMKSADEAKMLLNLTYK...................................................................................................................................................................................................................................................................................... 423
50 -12.300[R] KOG0151 Predicted splicing regulator, contains RRM, SWAP and RPR domains  ali follow..  8  148......................................................................................................................................................................................................................................................................................DELPDYFDPSGRLGSLDDGDPQTTNLYVVNLSSK-VDENFLLRTFGRFGPIASVKIMRHCGFVAFMNRADGEAAKEKMQGIIVYEYELKIGWGKVVFLPSQALPAPPPGHMAIRSK-EHLKQIIDTMALNVLDGGCAFEQAIMERGRGNPLFNFLFELGSKEHTYYVW-----------------------------------------------------------------------------------------------RLYSFAQGDTLQRWRTEPYIMIAGSGRWIPPPLPATRSPEHGKESRGTYAAGKSRCTEAEQTLTDSQRDEFEDMLRALTLERSQIREAM--------------------FALDNAEAAGE----VVEV---------LTESLTLKETSIPT--KVALM--LVSDII..... 496
51 -10.800[R] KOG4307 RNA binding protein RBM12/SWAN  ali follow..  8  334.KTLMPTPQAPFQNAPAPFTNGPSDDVNRPFQTGPPGNLGRNGPPPFQAGVPPPVIQNNMGRPIAPPAAMVRPP-GALPVFQAPVMTPIVPPVNKPMGAAAVEKFYIELTRLPTDLLRPAALEAFIHPTAPSSVKTVFGPGGIHIRLDSIADYATMMRRNGEQGIKIQQSDKKSFDTAIDGIPIPSVSMVPSKEQRSHE-------------------------------------------DDDKKSRRSRWENTSPIRSPRRSPLRRDNRDRSRSRSPPRRRRRSRSPRRREEHTDPTRWCVQVTNVPFRMKDEE-LLEWFSE--KVRPAKLTRTFWVAEFSSESLMKRSFG--IRTLCTGRTLRLRYIDNAKA----------------DEILKIEDVYGE---------------GKRQMNEEARLQHEVAEKANPPSFFNAPAATRGSGPMPPLNGTAPLPSGQQNGMNVPPPNGFNGAPMRGGFVPRGGNNFSQSRGGMMGRGGHGGGGGPQNFYQNGPNNFNNGPPEQQGQFRGNQGNDGGFRGGFRGGYRGRGGGRGGFQGGSRGDDSQPSQSELMELIKSI-----GPRGTVLSCNGFPKDVTLEDVVEFFND----YEPDRNSIRI-GDDGVMTGECMLACQNQENARRA-----SMDLDGQKLRNSVIS--VRII.......................... 948
52 -9.720[A] KOG1996 mRNA splicing factor  ali follow..  9  10....ETSDSKTEGWSKNF-QVKKAALTQAKSQRTKQSTVLAPVIDLKRGGSSDDRQIADTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQR------EERQRQRELERQKEIEEREKRRKDRHEASGFSRRPDPDSDEDEDYERERRKRSMGGAAIAPPTSLVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEPDRPRSPTGPSNSFLANMGGTVAHKIMQKYGFREGQGLKHEQGLSTALSVEKTSKRGGKIIVGDATEKGEAQDASKKSDSNPLTEILKCPTKVVLNMVGAGEVDEDLEVET-EKYGKVGKCVIFE---FLEFERVESAIKAVVDLNGRYFGGRVVKACFYNLDKFRVLDL........................................................................................................................................................................................................................................................................................................................................... 401
53 -9.430[K] KOG2068 MOT2 transcription factor  ali follow..  13  71.......................................................................................................................................................................................................................................................................DQERLASEGNMDRKKIQKSKPKSSDGRKPLTSVRVVQRNLVYIVGLPLNLADEDLLQEYFGQYGKVLKVSMSRTSVYITYGKEEEAIRCIQSVHGFILDGKALKACFGTTK.................................................................................................................................................................................................................................................................................................................................................. 196
54 -9.360[TR] KOG4019 Calcineurin-mediated signaling pathway inhibitor DSCR1  ali follow..  13  2....................................................................................................................................................................................................................................................................................................EEVDLQDLPSATIACHLDPRVFVDAKFESLFRTYDKDITFQYFKSFKRINFSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHL........................................................................................................................................................................................................................................................................................................................................... 96
55 -9.310[T] KOG0116 RasGAP SH3 binding protein rasputin, contains NTF2 and RRM domains  ali follow..  10  1MALESNAPVVDP---NTIGN----LYKSPSLDDSVLGRPGSDGEMVSVKSLK-----------------AINEQIMSFDYEISKIQILTADSQASYMNG-LVTGLLTVKEGQRMRFSQSFF--------------LVPLNGSYFVLNDVFRYVADEIVEPEANKKEVEEVIPQVVQPTEQVDEVAEPVTIPTQQPEAKQTTENTVKKPERAVANGHPKTQEDNVVNDKSNGVDAPKKSFAHIVQDLAQNGATFN----AKASPAKPKSKPVTKPSAARESKAPAPVSEHSSAATIDQQAEGYTIFVANLLMD-ATPEQLNETFKGFGAITKDGIQNCFGFVTFASAEAVKLVLQAESAIRIGNRRVSIEEKRGNNDNGRP............................................................................................................................................................................................................................................................................................................................................ 364
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;