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Query: [J] KOG0129 Predicted RNA-binding protein (RRM superfamily), from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPSPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDPLEKQQLSPSPGQEAGILPETEKAKSEENQGDNSSENGNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSSTIINEDASFFHQGGVPAASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRNAAFNQLPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGGSQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDTIKARTYGRRRGQSSLFPMEDGFLDDGRGDQPLHSGLGSPHCFSHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDRPRHISFRWNLast
1 -155.000[J] KOG0129 Predicted RNA-binding protein (RRM superfamily)  ali  100  1MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPSPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDPLEKQQLSPSPGQEAGILPETEKAKSEENQGDNSSENGNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSSTIINEDASFFHQGGVPAASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRNAAFNQLPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGGSQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDTIKARTYGRRRGQSSLFPMEDGFLDDGRGDQPLHSGLGSPHCFSHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDRPRHISFRWN 712
2 -51.800[A] KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1  ali follow..  15  3...............................................................................................................................................................................................................................................................................................................................................................................................................................TTVSTGATAVATLRETSPPVDGHEEARLNADSDDGSQDPGKMFIGGLSWQTTAENLRDYFGRFGEVNECMVMRD--PATKRARGFGFITFVDPSSVDKVLNNREHELDGKKIDPKVAFPKRTQAK-----------------LVTKTKKVFIGGLSATSTLEDMKQYFET-YGKVEDAMLMFDKATQRHRGFGFVTFDSDEVADKVCEIHFHEINGKMVECKKAQPKEVMLPVQLNKSRAAAARNLYGMPPETLLAYAQYL--------PRFGGNLMYPNFTNVFNNMPGGYSG... 271
3 -36.100[K] KOG0147 Transcriptional coactivator CAPER (RRM superfamily)  ali follow..  13  24........................................................................................................................................................................................................................................................................................................................................EQQRKEVKKDYPSNTTSSTSNSGNETSGSSTIGETSNRSRDRDRYRRRNSRSRSPGRQCRHRSRSWDRRHGSESRSRDHRREDRVHYRSPPLATGYRYGHSKSPHFREKSPVREPVDNLSPEERDARTVFCMQLAARIRPRDLEDFFSAVGKVRDVRIISD--RNSRRSKGIAYVEFCEIQSVPLAIGLTGQRLLGVPIIVQASQAEKN---------RLAAMANNLQKGNGGPMRLYVGSLHFNITEDMLRGIFEP-FGKIDNIVLMKDSDTGRSKGYGFITFSDSECARRALEQNGFELAGRPMRVGHVTER...................................................................... 326
4 -34.900[R] KOG0149 Predicted RNA-binding protein SEB4 (RRM superfamily)  ali follow..  12  7.....................................................................................................................................................................................................................................................................................................................................................................................................................................................PGSGFHYLNSPFGDTTFTKVFVGGLAWETQSETLRQHFEQYGEILEAVVIAD--KNTGRSKGYGFVTFRDPEAARRACADPTPIIDGRRANCNLASLGRPRPPL-------------------PYAVIPNMPDLLPRTLEMCRVLEVH-LLEIIRISNHFHITTSKELSILMVTAYGPEYMYSQSQGLYSPYMGQQYLQVYGVP....................................................................... 188
5 -34.200[K] KOG4210 Nuclear localization sequence binding protein  ali follow..  8  1..........................................................................................................................................................................................................................................................................................................................................MSETELSKEDAVTKKDNEEQVKKALLDPTKKRKAEDEIEIDLKSSIPLSKKQKRLLRRGKVTLEELNAKYNIDPKSIEEYKEDAEKKKSGASEKDAQGEESTINTPTGDESGEVVKKKKKDENKYGVWIGNLSFDTTKDDLVRFFIAKTKDNEDEKSR-KNSNAMKNKGFCYMFFKNVEQMKAVLELSESHLNGRNMLIKDSENYSGRPDKDD---------LVAMSKNPPSRILFVGNLSFDVTDDLLRKHFQH-CGDIVKIRMATFEDSGKCKGFAFIDFKNEEGSTNELKDSCRKIAGRPLRMEYGEDR...................................................................... 318
6 -34.000[A] KOG0131 Splicing factor 3b, subunit 4  ali follow..  16  8.....................................................................................................................................................................................................................................................................................................................................................................................................................................................GVGANLLGQHSAERNQDATVYVGGLDAQLSEELLWELFVQAGPVVNVYVPKD--RVTNLHQNYGFIEYRSEEDADYAIKVLNIKLHGKPIRVNKASQDKKSL--------------------DVGANLFIGNLDPDVDEKLLYDTFSA-FGVIASNPIMRDPDTGNSRGFGFISYDSFEASDAAIESTGQYLSNRQITVSYAYKKDTKGER................................................................ 198
7 -33.600[A] KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily)  ali follow..  20  112.....................................................................................................................................................................................................................................................................................................................................................................................................................................................SPLQSMAAQRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWD--SVTMKHKGFAFVEYEVPEAAQLALEQMNVMLGGRNIKVGRPSNIGQAQPI----------IDQLAEEARAFNRIYVASVHQDLSDDDIKSVFEA-FGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSNLFDLGGQYLRVGKAVTP...................................................................... 305
8 -33.500[A] KOG0146 RNA-binding protein ETR-3 (RRM superfamily)  ali follow..  19  37.....................................................................................................................................................................................................................................................................................................................................................................................................................................................SHSPGNPSTIPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKD--RFTGMHKGCAFLTYCERESALKAQSALHEQ--------KTLPGMNRPIQVKPADSESRGGSSCLRQPPSQDRKLFVGMLNKQQSEDDVRRLFEA-FGNIEECTILRGP-DGNSKGCAFVKYSSHAEAQAAINAQTMPGASSSLVVKFADTD...................................................................... 233
9 -31.400[A] KOG0115 RNA-binding protein p54nrb (RRM superfamily)  ali follow..  15  2.............................................................................................................................................................................................................................................................................................................................................................SGARRDNRRSNGRDDSSRVAKAENDRKPGRENRGGDEKRGNSNNAARSGGGGGGNRGGAERGIAPAQQPYDNNGGHRSGGGGGRSGGGGTSQLMDEVPKKKFTGRCRLFVGNLPNEVKETELKELFSPHGDIAECYLSG---------KGFAFLRLDTRAHAESAKEA-----------IDGRIIHGRQVRVR----------------AVHGAAIRVKELSPTVSNEMLYHAFSH-FGDVERAVHIVD-EKGRPTGEGIVEFERKPNCNEAMAA----IRDKVFLLTASPKPLICEEPRDEDDGLAERMIPRTPGLSKERELGPRFPTP------EYVYGMKWKELYVVE-QKRRAQLD... 327
10 -31.000[A] KOG0144 RNA-binding protein CUGBP1/BRUNO (RRM superfamily)  ali follow..  13  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................MNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNA----------------LHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSS-FGQIEECRILRGP-DGLSRGCAFVTFTTRAMAQTAIKAQTMEGCSSPMVVKFADTQKDKEQKR............................................................... 196
11 -29.600[A] KOG0105 Alternative splicing factor ASF/SF2 (RRM superfamily)  ali follow..  18  2..........................................................................................................................................................................................................................................................................................................................................................................................................................................................SGWADERGGEGDGRIYVGNLPTDVREKDLEDLFYKYGRIREIELKNR-----HGLVPFAFVRFEDPRDAEDAIYG--YDYGQCRLRVEFPRTYGGRG-------GWPRGGRNGPPTRRSDFRVLVSGLPPSGSWQDLKDHMRE-AGDVCYADV-------QKDGVGMVEYLRKEDMEYALRKDDTKFRSHEGETSYIRVYPERSTSYGYSRSRSGSRGRDSPY............................................... 206
12 -29.200[R] KOG4733 FOG: RRM domain  ali follow..  16  50..........................................................................................................................................................................................................................................................................................................................................................................................................................................................SSSNSGWDQLSKTNLYIRGLPPHTTDQDLVKLCQPYGKIVSTKAILD--KTTNKCKGYGFVDFDSPAAAQKAVSA----LKASGVQAQMAKQQEQD-----------------------PTNLYISNLPLSMDEQELENMLKP-FGQVISTRILRDS-SGTSRGVGFARMESTEKCEAVIG----HFNGKFIKTP........................................................................... 209
13 -29.100[R] KOG0118 FOG: RRM domain  ali follow..  16  156.....................................................................................................................................................................................................................................................................................................................................................................................................................................................RRMNARTSMAQREDVIRRTVYVSDLDQQVTEEQLAGLFVSCGQVVDCRICGD----PNSVLRFAFIEFTDEEGAMTALNLSGTMLGFYPVKVLPSKTAIAPV-------NPTFLPRTEDEREMCARTIYCTNIDKKVTQSDVKIFFESFCGEVYRLRLLGD--YQHSTRIAFVEFVMAESAIAALNCSGVVLGSLPIRVSPSKTPVRPRSPR............................................................... 354
14 -29.000[AJ] KOG0123 Polyadenylate-binding protein (RRM superfamily)  ali follow..  13  2.............................................................................................................................................................................................................................................................................................................................................................................................................................................................NAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRD--MITRRSLGYAYVNFQQPADAERALDTMNDVIKGKPIRIMWSQRDPSLRK-------------------SGVGNVFIKNLDKSIDNKALYDTFSA-FGNILSCKVVCDE--NGSKGYAFVHFETQEAADKAIEKNGMLLNDRKVFVGRFKSRKEREAELGAKAKEFT------NVYIKNFG--EEVDDESLKELFSQFGKTLSVKVMRDPNGKSKGFGF... 235
15 -28.900[A] KOG0145 RNA-binding protein ELAV/HU (RRM superfamily)  ali follow..  13  27...................................................................................................................................................................................................................................................................................................................................................................................................................................................NNRNCPSPMQTGATTDDSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRD--KITGQSLGYGFVNYIDPKDAEKAINTLNLRLQTKTIKVSYARPSSASIR---------------------DANLYVSGLPKTMTQKELEQLFSQ-YGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGNGQKPSGATEPITVKFANNPSQKSS-VGMNIPGHTGTGWCIFVDESVLWQLF--------GPFGAVNNVKVIRDFNTNKCKGFGF... 342
16 -28.700[A] KOG4212 RNA-binding protein hnRNP-M  ali follow..  13  45............................................................................................................................................................................................................................................................................................................................................................................................................................................QNEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEVGEVTYVELLMDAE---GKSRGCAVVEFKMEESMKKAAEV--HSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGHALQAGRLGSTVFVANLDYKVGWKKLKEVFSM-AGVVVRADILEDKD-GKSRGIGTVTFEQSIEAVQAISMNGQLLFDRPMHVKMDERALPKGDF................................................................ 288
17 -28.700[A] KOG0128 RNA-binding protein SART3 (RRM superfamily)  ali follow..  15  557..................................................................................................................................................................................................................................................................................................................................................................................................................................PSNAKSSSAVSSSNASSTPAPGSFAVQKAAPGTEDARTIFVSNLDFTTTEDEIRQAIEGVASIRFARKANS----DLVHRGFAYVVMENDQKAQQALLKDRVPVKGRPMFISANDPEKRV--------------GFKFSTTLEKSKVFVRNVHFQATDDELKALFSK-FGTVTSVRRVTHKD-GKPKGIAFVDFDTEASAQKCVASDKLMLRERELEVALSNPPVKKDKSHGKPAAIGASLEEDGP................................................ 783
18 -26.800[A] KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins  ali follow..  12  4...............................................................................................................................................................................................................................................................................................................................................................................................................................................................GTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNNVEMDWVLKH--------TGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSG-LEIVPNGITLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYPYRATENDIYNFFSPL-----------PVRVHIEIGPDGRVTGEAD... 332
19 -26.700[A] KOG4209 Splicing factor RNPS1, SR protein superfamily  ali follow..  14  59...................................................................................................................................................................................................................................................................................................................................................................................................................................................QSNSSQSLLTPEEKAEADAKSVYVGNVDYGATAEEIEQHFHGCGSVSRVTIQCD--RFSGHPKGFAYVEFTEKEGMQNALAMTDSLLRGRQIKVDPKRTNKPGMSTTNRPPFRGRGGRGRGNV--IVKYVYAGGFRPRGRGARRRPGFAP-Y............................................................................................................................. 205
20 -26.500[A] KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily)  ali follow..  15  42........................................................................................................................................................................................................................................................................................................................................................................................................................................................GPPPGWDAAPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMD---FNGNNRGYAFVTFSNKVEAKNAIKQ----LNNYEIRNGRLLGVCASVD---------------------NCRLFVGGIPKTKKREEILSEMKK-VTEGVVDVIVYAADKTKNRGFAFVEYESHRAAAMALLPGRIQLWGHGIAVDWAEPEVEVDEDTMSSVKILYVRN---MLSTSEEMIEKEF--------------NNIKPGAVERVKKIRDYAF... 270
21 -25.800[AJ] KOG0148 Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily)  ali follow..  14  2.................................................................................................................................................................................................................................................................................................................................................................................................................................................................EDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMD----TAGNDPYCFVEFHEHRHAAAALAAMNRKIMGKEVKVNWATTPSSQKK-----------------DTSNHFHVFVGDLSPQITTEDIKAAFAP-FGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVN--LTEQLMRQTF--------SPFGQIMEIRVF------PDKGYSF... 242
22 -25.700[A] KOG0120 Splicing factor U2AF, large subunit (RRM superfamily)  ali follow..  16  82...........................................................................................................................................................................................................................................................................................................................................................................................................................................................PVVGSTITRQARRLYVGNIPFGVTEEEMMEFFNQQMHLVGLAQAAGSACQINLDKNFAFLEFRSIDETTQAMAFDGINLKGQSLKIRRPHDYQPMPGITD-KPAVVSSGVISTVVPDSPHKIFIGGLPNYLNDDQVKELLLS-FGKLRAFNLVKDAATGLSKGYAFCEYVDLSITDQSIAGNGMQLGDKKLIVQRASVG...................................................................... 286
23 -25.000[A] KOG4206 Spliceosomal protein snRNP-U1A/U2B  ali follow..  13  2..............................................................................................................................................................................................................................................................................................................................................................................................................................................................LTADIPPNQSIYIQNLNERIKKEELKRSFSQFGRILDVVALK-----TPKLRGQAWVTFSEVTAAGHAVRQMQFPFYDKPMRLQYAKAKSDCLAKAEGTFVAPSFQPSGQETMPPNNILFIQNLPHETTSMMLQLLFEQ-YPGFKEIRMIDAK-----PGIAFVEYEDDVQASIAMQP----LQGFKITPQNPMV....................................................................... 226
24 -24.900[R] KOG0110 RNA-binding protein (RRM superfamily)  ali follow..  10  236........................................................................................................................................................................................................................................................................................................................................................................................................................................................KKPKAKADKSNLELFTIKIHNVPYNTKRQEVLKFFKPLKPYSV--------RLPSKVHGFCYVGFKTEKDMAKGMLKNKSFIKGKQVFFSGQPLAPAAVDAGNAKWKHQQDSLSKEDDISESGRIFFRNLAYTTTEEDLRKLFEQ-FGPVVEVNLPLDKLTRKIKGFGTVTYMMPEHALKAFNTDGTDFHGRLLHLLPSKDIEKNPKEDLDENDAS........................................................ 457
25 -24.900[J] KOG0899 Mitochondrial/chloroplast ribosomal protein S19  ali follow..  19  1................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MESRHFATA--LVFLASKGFVDILYWVYRFQASSMAFCTKLGGHWKQGVNVPVSSMLGSL-------------------YMSTKLYIGGLSPGTDEHSLKDAFSS-FNGVTEARVMTNKVTGRSRGYGFVNFISEDSANSAISANGQELNGFNISVNVAKDW...................................................................... 142
26 -23.800[AR] KOG1365 RNA-binding protein Fusilli, contains RRM domain  ali follow..  9  165..........................................................................................................................................................................................................................................................................................................................................................................................................................................................LEDQEVGADGDNVVCRARGLPWQASDHHVAQFFAGLDIVPGGIALCLSSE--GRRNGEVLVQFSSQESRDLALKRHRNFLLSRYIEVYKAGLDEFMHVATGSSTEAMEFVSANA------IIVRMRGLPYDCTDAQIRTFFEP-LKLTDKILFITRTD-GRPTGDAFVQFETEEDAQQGLLKHRQVIGQRYIELFKSTAAEVQQVVKRCNLINSSPAVANAPYEATVQHIVTFL------GDFATMVKFQGVHMVYNNQGHPSGEAF... 432
27 -23.500[A] KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily)  ali follow..  19  12....................................................................................................................................................................................................................................................................................................................................................................................................................................................DQHFKGSRSEQERSLRDSCTLYVGNLSFYTTEEQIHELFSRCGDVRVIVMGLD--KYKKTPCGFCFVEYYVRSEAEAAMRFVNTRLDDRLIRVDWDAGFVEGRQ---------------------YGRGKTGGQVRDEYRTDYDAGRGG-YGKLLSQKIAPNTDNR.............................................................................................................. 154
28 -23.200[A] KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily)  ali follow..  14  2......................................................................................................................................................................................................................................................................................................................................................................................................................................................................VRVYIGRLPNRASDRDVEHFFRGYGKLSDVIM----------KNGFGFVDFQDQRDADDAVHD--KELCGERVILEFPRRKVGYNE-TFRKGGERQFSNRYSRPCSTRFRLVIDNLSTRYSWQDIKDHIRK-LGIEPTY----SEAHKRNVNQAIVCFTSHDDLRDAMNK--EDLNGRKLKCTDETRD...................................................................... 187
29 -23.100[D] KOG2186 Cell growth-regulating nucleolar protein  ali follow..  15  399.............................................................................................................................................................................................................................................................................................................................................................................................................................................................ESADRDIAQRNIFVRGFGWDTTQENLKTAFESYGEIEECSVVMD--KDTGRGKGYGFVMFKTRKGAREALKRPEKRMYNRIVVCNLASEKPGK.............................................................................................................................................................................. 489
30 -23.000[R] KOG0125 Ataxin 2-binding protein (RRM superfamily)  ali follow..  12  3...................................................................................................................................................................................................................................................................................................................................................................................................................................................KKKMVTQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPT---EYGVPHTQ---YAGQTGEHNLTLYGSTQAHGEQSSNSPST-------------QNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQ-FGKILDVEIIFNE--RGSKGFGFVTFENSADADRAREKHGTVVEGRKIEVNNATARVMTNKK................................................................ 195
31 -22.700[R] KOG0226 RNA-binding proteins  ali follow..  10  97.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................VPPSIFMPPQLRAAPIMFPPRVLGIPAPATIEGAPA--LYETPAVNAIPQELLRTQALQSDIDKMNFKK-----FKKKIKEQQAKKKFVRSGGGQVWEDPSLAEWDENDFRVFCGDLGNEVSDELLAKAFRK-YPSFQKAKVVRESRTNKSKGYGFVSFRDSEDYVRAMREDGKYVGNRPIKLRKSAWKERNIDVIKQKRKQKK....................................................... 297
32 -22.200[J] KOG0122 Translation initiation factor 3, subunit g (eIF-3g)  ali follow..  12  98..........................................................................................................................................................................................................................................................................................................................................................................................................................................................MVSTEEILLERPRAPGTKADESKATGDGLSQLGKGGAVLMVCRICHK--KGDHWTSKCPYKDLAAPTDVFIDKPP---TGESSTMSAAPGTGKAAYVPPSMRAGADRSAVGSDMRRRNDENSVRVTNLSEDTREPDLMELFHP-FGAVTRVYVAIDQKTGVSRGFGFVNFVSREDAQRAINK--YGYDNLILRVEWATPR...................................................................... 292
33 -21.900[D] KOG4660 Protein Mei2, essential for commitment to meiosis, and related proteins  ali follow..  15  166...................................................................................................................................................................................................................................................................................................................................................................................................................................................RPNTAGRVSVEHPNGEHPSRTLFVRNINSSVEDSELSALFEPFGEIRS--------YTACKSRGFVMISYYDIRAAHAAMRAQNTLLRKRTLDIHFSIPKENPSEKD-----------------MNQGTLVIFNVDTTVSNDELLQLFGA-YGEIREI-----RETPNRRFHRFIEYYDVRDAETALKANRSEIGGKCIKLELSRPGGARRLS................................................................ 350
34 -21.100[K] KOG1548 Transcription elongation factor TAT-SF1  ali follow..  15  75...................................................................................................................................................................................................................................................................................................................................................................................................................................KRLYESTSAEGYPSGSRNKKSKSENSEASPAPVINKAVYIQGLPLDVTVDEIEEVFKKCGVIAKNIDNGTYRTEDGTPKGDALIVFFRSESVELAEQEKTVNKDVGGALKKKALRLRQQQMQQISSWDDVDEEVDDKRKKRFNKIVVLKHI--IDLKDDITEEAEK-CGRVTNVVLYDKE----PDGVVTVRFSNNEEAEACVRL----MQGRYFDGRV.......................................................................... 326
35 -20.000[A] KOG4207 Predicted splicing factor, SR protein superfamily  ali follow..  17  2..........................................................................................................................................................................................................................................................................................................................................................................................................................................................SCGRPPPDVDGMITLKVDNLTYRTSPDSLRRVFEKYGRVGDVYIPLE--PHTKAPRGFAFVRFHDRSDAQDAEAAMDAVLDERELRVRMARYGRRD.............................................................................................................................................................................. 96
36 -19.700[A] KOG0108 mRNA cleavage and polyadenylation factor I complex, subunit RNA15  ali follow..  24  2.................................................................................................................................................................................................................................................................................................................................................................................................................................................................SMTAGNVVFVGNIPYDVSEQQMTEIFNQVGPVKTFKLVLD--PETGSGKGYGFCEFFDSETTAMAVRK--SELGPRKIRVEFPSNDPRRNQ............................................................................................................................................................................ 91
37 -19.600[A] KOG0107 Alternative splicing factor SRp20/9G8 (RRM superfamily)  ali follow..  26  2......................................................................................................................................................................................................................................................................................................................................................................................................................................................................SRVYVGNLDPRVTERELEDEFRSFGVIRSVWVARR-------PPGYAFLDFEDSRDARDAIRE--KNGWRVEQSHNRGGGGGRG.............................................................................................................................................................................. 79
38 -19.300[R] KOG0130 RNA-binding protein RBM8/Tsunagi (RRM superfamily)  ali follow..  14  18.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DGDQGIVRLKEKAKHRKGRGF---SDSNTREAIHSYERVRNEDDDELEPGPQRSVEGWILFVTSIHEEAQEDEIQEKFCD-YGEIKNIHLNLDRRTGFSKGYALVEYETHKQALAAKEA--AEIMGQTIQVDWCFVK...................................................................... 152
39 -18.700[R] KOG0114 Predicted RNA-binding protein (RRM superfamily)  ali follow..  15  2.........................................................................................................................................................................................................................................................................................................................................................................................................................................................NKRNHIRLPPEVNRLLYVRNLPYKITSDEMYDIFGKFGAIRQI-----RVGNTPETRGTAFVVYEDIFDAKNACDHLSFNVCNRYLVVLYYQSNKAFKRVDMDKKQEELNNIKAKYNLKTPEA.................................................................................................................................................... 120
40 -18.100[A] KOG1190 Polypyrimidine tract-binding protein  ali follow..  13  32...........................................................................................................................................................................................................................................................................................................................................................................................................................................SSNSASAANGNDSKKFKGDSRSAGVPSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKG--------KNQAFIEMNTEEAANTMVTSVTPVLRGQPIYIQFSNHKELKTDSSPNQARAQAALQAVNAGQSPVLRIIVENLFYPVTLDVLHQIFSK-FGTVLKIITFTKN----NQFQALLQYADPVSAQHAKLS--QNIYNACCTLRIDFSK...................................................................... 259
41 -18.100[R] COG0724 RNA-binding proteins (RRM domain)  ali follow..  15  173....................................................................................................................................................................................................................................................................................................................................................................................................................................................ARDPSSDAYRDSRERDDMCTLKIMQVNENADENSLRELLFPFAPIPRVSVVRN--KETGKSRGLAFVTFSSEEVAEQALRF--RGYMNLILRVEWSKPKVKE.............................................................................................................................................................................. 274
42 -17.900[R] KOG4208 Nucleolar RNA-binding protein NIFK  ali follow..  16  2.................................................................................................................................................................................................................................................................................................................................................................................................................................................................AAFSRSAGPILSLNP-QEDAELQKEVAQCDTVTRFRLSRK--KRTGNSKGYAFVEFESEDVAKIVTETMNYLFGERLLECHFMPPEKKMESI........................................................................................................................................................................... 91
43 -17.700[R] KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains  ali follow..  11  212..........................................................................................................................................................................................................................................................................................................................................................................................................................................................DRYSDWNPGVPSNKLAILNMPNDVDNTKITLSLGKCGYLPQD-TMTKFDKNTKQIRTFAFVEFSNRETAEQWMTDYEGWLDGRTLAVEYAKGDPAAGSGNK-QSMELEKLGAHMVGMTPCDTLLIRGLPDGINNSLIFDSLGA-LVCLSSI---SMIKLSESKRFAYLQMKSADEAKMLLNL--IRIKDKDVQVSWC......................................................................... 438
44 -17.400[AR] KOG0109 RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains  ali follow..  12  2...................................................................................................................................PRGPAAPRPPA-----PAASMGRCAPNAGSGPEAERSAAPSAGPPGPPLRPLGADPSPGSDPASPSSRPASRAQALRGPPKSRSPARLAARPQQPSAQKGHAAHGRVVGFGCAEREVPESAVARLCPRGCLRGAVPFLPRPRGPELLAGSE---ISADPVICCPRGSGLATPRTLSGKWLTDEGRASSGCLNPNRCKPAPHAEGVGAGSRGGARAQSVLSPSGDSREGDLLQFASSERARLTPMIPRPRLLRIHGAFRTKRFSVRDKED------------------QWTVSVQRQLVYRPSTEAGHNNKELPPPLPPRGACPDDEAVHQKPAPGHRAGDPLSFQAVGKVLECDII----------KNYGFVHIEDKTAAEDTIHN--YKLHGVNINVEASKNKSK-----------------------ASTKLHVGNISPTCTNQELQAKFEK-YGPVIECDIV--------KDYVLIHFIHMECCPQARLR........................................................................................ 431
45 -17.100[R] KOG4454 RNA binding protein (RRM superfamily)  ali follow..  17  2...........................................................................................................................................................................................................................................................................................................................................................................................................................................................EIKPTPSPPEERTIYVANFSEEVDEELLEELFIQAGPVVKVILRDV----RDSNAKFALVEFEDELSVLFAIEL--VRLFNQELQVKPRNGTNQEEL............................................................................................................................................................................ 95
46 -14.700[R] KOG0126 Predicted RNA-binding protein (RRM superfamily)  ali follow..  21  25...........................................................................................................................................................................................................................................................................................................................................................................................................................................................KVSWHSEYKDSAWIFLGGLPYELTEGDIICVFSQYGEIVNINLVRD--KKTGKSKGFCFLCYEDQRSTILAVDN--IKIKGRTIRVDHVSNYRAP.............................................................................................................................................................................. 118
47 -13.900[R] KOG4307 RNA binding protein RBM12/SWAN  ali follow..  9  147..........NNQNSYSNRQEISQNHQENSVKLKDPFGGDYGGYKFQQQPPPQINRYGSGPPPSKPADLSNTRSLPPVNNPPPPHPIPQFPPEKQFGNKLGNNNDVSSRENHIQGSGNERVQGGDSWRDTSFNQPPRNDFKGNYNNAYSSNKYKNNYKAPEFNNDFNGGNKFNQFPPRNAQSTDLSENRAAPPQTGR----------KTLMPTPQAPFQNAPAPFTNGPSDDVNRPFQTGPPGNLGRNGPPPFQAGVPPPVIQNNMGRPIAPPAAMVRPPPQNFPGGAGGALPVFQAPVMTPIVPPVNKPMGAAAVEKFYIELTRLPTDTLSSVKTVFGPGGIHMHTIIRLDSIADYATMMRRNGEQGIKIQQSDKKSFDTAIDGIPIPSVSMVPSKEQRSHEDDDKKSRRSRWENTSPIRSPRRSPLRRDNRDRSRSRSPPRRRRRSRSPRRREEVQVTNVPFRMKDEELLEWFSE--KLTRTF------YSDGNASDRWVAEFSSESLMKRSFGIRTLCTGRTLRLRYIDNAKADEILKIEDVYGEGKRQMNEEARLQHEVALSCNGFPKDVTLEDVVEFFNDY--EPDRNSIRI-GDDGVMTGECMLACQNQENARRASMD---KLRNSVISVRI.......................................................................... 947
48 -13.400[R] KOG0151 Predicted splicing regulator, contains RRM, SWAP and RPR domains  ali follow..  12  19.....................................................................................................................................................................................................................................................................................................................................................................................................................................................NTEKKKKPRRRERRMKQLVCIPNDNKLKPDSQGMFPPFVKDQRIRDEERSKE--MEKGKTRNID--HFVEELKREQEIRERRNQDRENSRDHNSDNTSSSRFDELPDYFDPSGRLGSLDDGDPQTTNLYVVNLSSKVDENFLLRTFGR-FGPIASVKIMTEEEKRRERHCGFVAFMNRADGEAAKE----KMQGIIV.............................................................................. 240
49 -13.300[K] KOG4661 Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B)  ali follow..  7  31LSD--LRVVRKRNSGNKSVLMERLKKAIEDEGGNPDEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVK----------------------------------------ESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESST-----------------------------------------------------SEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTN--ARSPGARCYGFVTMSTAEEATKCINH--TELHGKMISVEKAKNEPVG.............................................................................................................................................................................. 488
50 -12.100[R] KOG1457 RNA binding protein (contains RRM repeats)  ali follow..  23  82...........................................................................................................................................................................................................................................................................................................................................................................................................................................................FVHELKTRPGVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLIKLT------ARQPVGFVIFDSRAGAEAAKNA................................................................................................................................................................................................... 149
51 -11.700[A] KOG0533 RRM motif-containing protein  ali follow..  6  8...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DLSLEDIISKTRKTTGSI--RPTGLPRRSGGSGGWKDLDAVQNHGISSRGNDSKVIRVNISNLAPTVISSDLEELFGDY--RLSSVSVNFNEH-GDSLGTGDISLTKRDAERLVQKFSGVALDGKIMKFAVIDSS...................................................................... 150
52 -11.400[R] KOG2135 Proteins containing the RNA recognition motif  ali follow..  9  28LAKYVLALVKKPDKGHDEL--------------KAFTNEQLNVFLTDHTAP--------------------DKVFEALTSKSYMPASTAPTSASATAPDLKKEKAPAEKPSKPTAPPGVQKSSSSPSASKAESRPLRKRISPPPSENREKEKQSRDKERRRSRSPRDRRGRATTSRSGRTSSSDRDRH--------------------SKRRSRSRSRSSSGSRTPPYKSRSSRRRCKDFEERGYCIRGDQCPYYHGRDPVVVDENALGSMVPLPATAPNFSLPPPGYNPLNPPPPGVVVAAGEYNPEAPALNNYSIPPPPIPGQWQQPHVAAQYVPQSVSSYSQPPPAAAQGVVTQPGSFRGAPRGRGNI----------------------------------------------------------------RGRGGFARGGFTGAINRDNCTLQVAKIPPENTIAKLNEHFATFGTVDNIQVRYNGEIDS------ALVTYASKFDAGKAYKSPTPVLNNRFIKVQHNIILDKWMVKQKELLIKARTSTDETDK-KMSSVVIVRGVTDE-LVTDLMAHMEK-FGEVFDHSVKADDDGL----TAVFPFRKTGDALKAMADG--VLNGVDLE............................................................................. 677
53 -11.300[R] KOG0153 Predicted RNA-binding protein (RRM superfamily)  ali follow..  15  219...........................................................................................................................................................................................................................................................................................................................................................................................................................................................PTLEPPEDRNITTLYVGNLPEEITEPELRDQFYQFGEIRSIALVPR--------QQCAFVQYTKRNAAELAAERTFNVIQGRKVSIKWAHSQAKQGT............................................................................................................................................................................ 309
54 -10.400[R] KOG4198 RNA-binding Ran Zn-finger protein and related proteins  ali follow..  12  29............................................................................................................................................................................................................................................................................................................................................................................................................................................................DHGISIGRAPCEIHICWVILDGKTLEKQHCESCS-SLTEAIFTLDQERLNFQGKPFTFVVMNG--ELRVLLPKEARDQGNATTLLLRKAEKDSRGHSLPSVLTQPINCQADARSAERSKIVHVAGLTNDVTQLELESWFTNHGVHPVALWTLKTPEPYKSTGTGFVLFASHEDAADALAFNGYCLGDRMLEIIPSSTKVLDKASD-IPFPSSKNRPRPGDWNCPMCGFSNF-CFRC................................ 366
55 -10.200[R] KOG1995 Conserved Zn-finger protein  ali follow..  10  1...............................................................................................MAGMYNQDGGGGAPIPSYGGDGYGGGGGYGGGDAGYGGRGASG-------GGSYGGRGGYGGGGGRGNRGGGGGGYQGGDRGGRGSGGGGRDGDWRCPNPSCGNVNFARRVECNKCGALAPSGTSSGANDRGGGGYSRGGGDSDRGGGRGGRNDSGRSYESSRYDGGSRSGGSYGSGSQRENGSYGQAPPPAAAIPSYDGSGSYPPPTGYGMEAVPPPTSYSGGPPSYGGPRGGYGSDAPSTGGRGGRSGGYDGGSAPRRQEASYEDAATEKVKQ-------------------------------------------------------------------------CDADCDDNCDNARIYISNLPPDVTTDELKDLFGGIGQVGRIKQKRGYKDEKGNYKGDACLAYEDPSAAHSAGG---YEMRGNKISVTMAEKSAP............................................................................................................................................................................... 374
56 -10.100[T] KOG0116 RasGAP SH3 binding protein rasputin, contains NTF2 and RRM domains  ali follow..  12  251............................................................................................................................................................................................................................................................................................................................................................................................................................................AARESKAPAPVSEHSSAATIDQQAEGYTIFVANLLMDATPEQLNETFKGFGAITKDGIQVRSYRL--KGNCFGFVTFASAEAVKLVLQAHKIRIGNRRVSIEEKRGNND............................................................................................................................................................................... 360
57 -10.000[K] KOG3152 TBP-binding protein, activator of basal transcription (contains rrm motif)  ali follow..  8  14..................................................................................................................................................................................................................................................................................................................................................................................................................................SEEKESKETMKSQKADRKKKKLKEKLLKEASKADNRGVCYLSRIPPHMDHVRLRHILAQYGELGRIYLAPEAGGFRGQRFSEGWVEFAKKSVAKRVADMSKIEKSRAMTEIDARMEKKRKIQEESGSNAEAAPVFPPRAIFQFRQKKSIENETSQSKPGLSTDFLASVFGG........................................................................................................................... 265
58 -9.750[A] KOG4213 RNA-binding protein La  ali follow..  11  2.........................................................................................................................................................................................................................................................................................................................................................................................................................................................AENGDNEKMAALEAKI-----------HQIEYYFGDFNLPRDKFLK----EQIKLDEGW-MIKFNRLNRLTNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKND------KNRSVYIKGFPTDATLDDIKEWLED-KGQVLNIQMRRTLHKAF-KGSIFVVFDSIESAKKFVETPGQKYKETDLLILFKDD....................................................................... 187
59 -9.580[K] KOG2068 MOT2 transcription factor  ali follow..  13  2...............................................................................................................................................................................................................................................................................................................................................................................................................................................................SDYGEKTCPLCAEEM--DLTDQQLKPCKCGYQICVWCWHHIMDMAEKDQSEG----PYDKEKIVGMTVDQ----------RLASEGNMDRKKIQKSKPKSSDGRKPLTSVRVVQRNLVYIVGLPLNLADEDLKEYFGQ-YGKVLKVSMSRTQQFPNNTCSVYITYGKEEEAIRCIQS--FILDGKALKACFGTTKY--------------------HAWLRNVACNNQDCLY----LHEVGSQED.................... 223
60 -9.470[K] COG5175 Transcriptional repressor  ali follow..  10  41................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DITDKNFF--------------------------GYQICQFRQNPELNGRCPACRRKYDDENVRLARKEKERKHREKERKENEYTNRKHLSGTRVIQKNLVYVVGINPPVPYEEVEKYFGQ-YGKINKIVVNRKTHHHSPGYGVYITFGSKDDAARCIAQ--TYMDGRLIKAAYGTTKY------CS-------------SYLRGLPCPNPNCMF----LHEPGEEAD.................... 260
61 -9.460[A] KOG4008 rRNA processing protein RRP7  ali follow..  9  39...............................................................................................................................................................................................................................................................................................................................................................................................................................................................KKDPSKENSIIVSNIPAFVGEGVVLAIIDQFASFEVEESFVQRSNSLSQGQLTMSITFDKPEAVIQTLALCQDVGPFTITDFLEDPEFPSVLK-----TTLYRKLFPSEEQIQEMADTYVERYDTEQTEARKEAKRKYS---------EPDED-----GWITVT-GGLNNKKKKVDLAYYTFQIKKNRQEQELLKKFEEDR--KRITQLKQARNFKPI............................................... 261
62 -9.330[A] KOG0113 U1 small nuclear ribonucleoprotein (RRM superfamily)  ali follow..  16  5.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................LPPN-----LLALFAAREPIPFM---LPHEKKSRGYLGVAKFMADFEDPKDTPLPKTVETRQERLERRRREKAEQVAYKLER-EIALWDPTEIKNATEDPFRTLFIARINYDTSESKLRREFEF-YGPIKKIVLIHDQESGKPKGYAFIEYEHERDMHAAYKHA-KKIDSKRVLVDVE......................................................................... 178
63 -9.060[A] KOG4849 mRNA cleavage factor I subunit/CPSF subunit  ali follow..  20  83............................................................................................................................................................................................................................................................................................................................................................................................................................................................GSLTPTMNRRYQLYVGNLTWWTTDQDIANSLRDIGVSDLQEVKFFENRANGQSKGFSVISLGSESSLRAVLDQ................................................................................................................................................................................................... 155
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;