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Query: [K] KOG0147 Transcriptional coactivator CAPER (RRM superfamily), from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MASDDFDIVIEAMLEAPYKKEEDEQQRKEVKKDYPSNTTSSTSNSGNETSGSSTIGETSNRSRDRDRYRRRNSRSRSPGRQCRHRSRSWDRRHGSESRSRDHRREDRVHYRSPPLATGYRYGHSKSPHFREKSPVREPVDNLSPEERDARTVFCMQLAARIRPRDLEDFFSAVGKVRDVRIISDRNSRRSKGIAYVEFCEIQSVPLAIGLTGQRLLGVPIIVQASQAEKNRLAAMANNLQKGNGGPMRLYVGSLHFNITEDMLRGIFEPFGKIDNIVLMKDSDTGRSKGYGFITFSDSECARRALEQLNGFELAGRPMRVGHVTERLDGGTDITFPDGDQELDLGSAGGRFQLMAKLAEGAGIQLPSTAAAAAAAAAAQAAALQLNGAVPLGALNPAALTALSPALNLASQCFQLSSLFTPQTMLast
1 -98.100[K] KOG0147 Transcriptional coactivator CAPER (RRM superfamily)  ali  100  1MASDDFDIVIEAMLEAPYKKEEDEQQRKEVKKDYPSNTTSSTSNSGNETSGSSTIGETSNRSRDRDRYRRRNSRSRSPGRQCRHRSRSWDRRHGSESRSRDHRREDRVHYRSPPLATGYRYGHSKSPHFREKSPVREPVDNLSPEERDARTVFCMQLAARIRPRDLEDFFSAVGKVRDVRIISDRNSRRSKGIAYVEFCEIQSVPLAIGLTGQRLLGVPIIVQASQAEKNRLAAMANNLQKGNGGPMRLYVGSLHFNITEDMLRGIFEPFGKIDNIVLMKDSDTGRSKGYGFITFSDSECARRALEQLNGFELAGRPMRVGHVTERLDGGTDITFPDGDQELDLGSAGGRFQLMAKLAEGAGIQLPSTAAAAAAAAAAQAAALQLNGAVPLGALNPAALTALSPALNLASQCFQLSSLFTPQTM 424
2 -63.800[A] KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily)  ali follow..  17  2........................................................ATATIALQVNGQQGGGSEPAAAVAAGDKWKPPQGTDSIKMENGQSTAAKLGLPPLTPEQQEALQKAAVTMGFGDPLSPLQSMAAQRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEMNSVMLGGRNIKVGRPSNIGQAQPIIDQL-AEEARAFNRIYVASVHQDLSDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGKAVTPPMPLLAVAAAAATAKITAQEAVAGAAVLGTLGT................................................................. 350
3 -61.100[AJ] KOG0123 Polyadenylate-binding protein (RRM superfamily)  ali follow..  18  2.......................................................NAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVVCD--ENGSKGYAFVHFETQEAADKAIEMNGMLLNDRKVFVGRFKSRKEREAELGAKAKEF----TNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDP-NGKSKGFGFVSYEKHEDANKAVEEMNGKEISGKIIFVGRAQKKVERQANLYIKNLDDTIDDEKLRKEFSPFGSITSEDGRSKGFGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRV...... 386
4 -58.300[A] KOG0115 RNA-binding protein p54nrb (RRM superfamily)  ali follow..  13  2............................................SGARRDNRRSNGRDDSSRVAKAENDRKPGRENRGGDEKRGNSNNAARSGGGGGGN-RGGAERGIAPAQQPYDNNGGHRSGGGGGRSGGTESQLMDEVPKKKFTGRCRLFVGNLPNEVKETELKELFSPHGDIAECYLS-------GKGFAFLRLDTRAHAESAKAIDGRIIHGRQVRVRFAVHGA------------------AIRVKELSPTVSNEMLYHAFSHFGDVERAVHIVD-EKGRPTGEGIVEFERKPNCNEAMAAIRDKVFSPKPLICEVLEPRDEDDGERMIPRTPGLSKERELGPRFPTPNSLYVVEQKRRAQLDEELRESRRRLESDMELAYQDYQAQMLREDLQRRQQE................... 363
5 -57.800[K] KOG4210 Nuclear localization sequence binding protein  ali follow..  17  2..........................SETELSKEDAVTKKDNEEQVKKALLDPTKKRKAEDEIEIDLKSSIPLSKKQKRLLRRGKVTLEELNAKYNIDPKSIEEYKEDAEKKKSGASEKDAQGEESTINTPTGDESGEVVKKKKKDENKYGVWIGNLSFDTTKDDLVRFFIAKTKDNEDEAAKNSNAMKNKGFCYMFFKNVEQMKAVLELSESHLNGRNMLIKDSENYSGRPDKDDLVAMSKNPPSRILFVGNLSFDVTDDLLRKHFQHCGDIVKIRMATFEDSGKCKGFAFIDFKNEEGSTNELKDKSCRKIAGRPLRMEYGEDRSKRQVR............................................................................................ 324
6 -56.700[A] KOG0145 RNA-binding protein ELAV/HU (RRM superfamily)  ali follow..  17  9...........................EPQVSNGPTSNTSNGPSSNNRNCPSPMQTGATTDDSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKLNGQKPSGATEPITVKFANNPSQKSSQMNIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAHKS.............................................................................................. 380
7 -55.300[A] KOG0131 Splicing factor 3b, subunit 4  ali follow..  27  11.......................................................................................................................................ANLLGQHSAERNQDATVYVGGLDAQLSEELLWELFVQAGPVVNVYVPKDRVTNLHQNYGFIEYRSEEDADYAIKLNMIKLHGKPIRVNKASQDKKSLDV-----------GANLFIGNLDPDVDEKLLYDTFSAFGVIASNPIMRDPDTGNSRGFGFISYDSFEASDAAIESMTGQYLSNRQITVSYAYKKDTKGER............................................................................................ 198
8 -54.900[AJ] KOG0148 Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily)  ali follow..  17  2...........................................................EDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMD--TAGNDPYCFVEFHEHRHAAAALAAMNGRKIMGKEATTPSSQKKDTSNHFHVFVGDLSPQITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQMGGQWLGGRQIRTNWATRKPPAPKSTYESNNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPD------KGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINYGNAQQIGQYMPNGWQVPAYGMYGQAWNQQGFNQTQSSAPWMGPNYGVQPPQGQNGSMLPNQPSGYRVAGYETQ................... 375
9 -54.100[R] KOG0118 FOG: RRM domain  ali follow..  15  12......AADAGGVVIQPPPSSPPSSMTSQDSGVSSDDQNHHSRIDQVLRHDQGLYSKIGSHVARSDGVDGGESFKRDMRELQELFSKLNPMAEEFVPPSLNKQGGNGVNGGFFTSAGSFFRNNGKKSFGQGKRRMNARTSMAQREDVIRRTVYVSDLDQQVTEEQLAGLFVSCGQVVDCRICGD--PNSVLRFAFIEFTDEEGAMTALNLSGTMLGFYPVKVLPSKTAIAPVNPTPRTEDEREMCARTIYCTNIDKKVTQSDVKIFFESFCGEVYRLRLLG-DYQHSTRIAFVEFVMAESAIAALN-CSGVVLGSLPIRVSPSKTPVRPRSP............................................................................................ 353
10 -52.500[A] KOG0146 RNA-binding protein ETR-3 (RRM superfamily)  ali follow..  21  37....................................................................................................................................SHSPGNPSTIPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKAQSLHEQKTLPGMNRPIQVKPADSESRGGSSCLRQPPSQDRKLFVGMLNKQQSEDDVRRLFEAFGNIEECTILRGP-DGNSKGCAFVKYSSHAEAQAAINALHGSQTASSSLVVKFADTDKERTMRRMQQMAGQMGMFNPMAIPFGAYGAYAQA................................................................ 267
11 -51.600[A] KOG0144 RNA-binding protein CUGBP1/BRUNO (RRM superfamily)  ali follow..  16  2..................................................NGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNQSKGCCFVTFYTRKAALEAQNALHNMKHHPIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGP-DGLSRGCAFVTFTTRAMAQTAIKMHQAQTCSSPMVVKFADTQKDKEQKGAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSK.............................................................................................. 480
12 -51.500[R] KOG4733 FOG: RRM domain  ali follow..  14  2.............................................................................................GKVWKQQMYPQYATYYYPQYLQAKQSLVPAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPHTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSLKASGVQAQMAKQQEQDP-------------------TNLYISNLPLSMDEQELENMLKPFGQVISTRILRD-SSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPKKRQNPNKYIPNGRPWHREGEVRLAGMTLTYD--PTTAAIQNGFYPSPYSIATNRMITQTSITPYIASPVSAYQVQSPSWMQPQPY............. 312
13 -50.800[A] KOG0120 Splicing factor U2AF, large subunit (RRM superfamily)  ali follow..  17  4............................................................DDRERDRERRRHRSRSRDRHRERSRDRRHHRNSRRKPSLYWDVPPPGFEHITPMQYKAMQASGQIPASVVPDTPQTAVPVVGSTITRQARRLYVGNIPFGVTEEEMMEFFNQQMHLVGLAQVLACQINLDKNFAFLEFRSIDETTQAMAFDGINLKGQSLKIRRPHDYQPMPGITDTPSTVVPDSPHKIFIGGLPNYLNDDQVKELLLSFGKLRAFNLVKDAATGLSKGYAFCEYVDLSITDQSIAGLNGMQLGDKKLIVQRASVGAKNAQDELRDEEEYEDILEDIKEECTKYGVVEGVEVPGCGKVFVEFNSVLDCQKAQQALTGRKFSDRVVVTS.......................... 404
14 -50.300[A] KOG0128 RNA-binding protein SART3 (RRM superfamily)  ali follow..  18  484........................................EREEGTLAELDLVLEKVNSQVAHRAIRPQKKVSEKPAPAPKSKQDHIQKRTSGGEPIVKKVKGDDGGFKAPLPPSNAKSSSAVSSSNASSTPAPGSFAVQKAAPGTEDARTIFVSNLDFTTTEDEIRQAIEGVASIRFARKANSD--LVHRGFAYVVMENDQKAQQALLKDRVPVKGRPMFISANDPEKRVGFKFSTTLEK-----SKVFVRNVHFQATDDELKALFSKFGTVTSVRRVTHK-DGKPKGIAFVDFDTEASAQKCVASGDKLMLRERELEVALSNPPVKKDKS............................................................................................ 767
15 -50.000[A] KOG0105 Alternative splicing factor ASF/SF2 (RRM superfamily)  ali follow..  16  2.........................................................................................................................................SGWADERGGEGDGRIYVGNLPTDVREKDLEDLFYKYGRIREIELKNR---HGLVPFAFVRFEDPRDAEDAIGRNGYDYGQCRLRVEFPRTYGGRGGRGGRNGPPTRRSDFRVLVSGLPPSGSWQDLKDHMREAGDVCYADV-------QKDGVGMVEYLRKEDMEYALRKLDDTKFRSHEGETSYIRVYPERSTS............................................................................................ 189
16 -49.300[A] KOG4212 RNA-binding protein hnRNP-M  ali follow..  21  35.................................................................................................................GPKGEGERPAQNEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVEKVGEVTYVELLMDA-EGKSRGCAVVEFKMEESMKKAAELNKHSLSGRPLKVKEDPDGEHARRAMQKHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDK-DGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDF............................................................................................ 288
17 -49.300[J] KOG0899 Mitochondrial/chloroplast ribosomal protein S19  ali follow..  16  1...............................................................................................................................................................................MESRHFATALVFLASKGFVDILYWVYRFQASSMACTKL---GGHWKQGVNVPVSSMLGSLRYM-------STKLYIGGLSPGTDEHSLKDAFSSFNGVTEARVMTNKVTGRSRGYGFVNFISEDSANSAISAMNGQELNGFNISVNVAKDWPSLPLSLDESIEEAEKKENKMMSRSVWKDPFKNAALNRKIWSRRSTILPEYVDSAVRIYNGKTHVRCKITEGKVGHK..................... 227
18 -48.100[R] KOG0226 RNA-binding proteins  ali follow..  17  81....................................................................................................................................SPFINPALGRLPTMPPVPPSIFMPPQLRAAPIMFPPRVLGIPAPATIEGAPALYETPAVNAIPQELLRTQALQSDIDMNFKKQTDPFKKKIKEQQAKKKFVRSDPSLAEWDENDFRVFCGDLGNEVSDELLAKAFRKYPSFQKAKVVRESRTNKSKGYGFVSFRDSEDYVRAMREMDGKYVGNRPIKLRKSAWKERNIDVIKQKRKQKK................................................................................... 297
19 -47.800[A] KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily)  ali follow..  12  2....................................................................................................ESNHKSGDGLSGTQKEAALRALVQRTGYSLVQEN-GPPPGWDAAPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDF-NGNNRGYAFVTFSNKVEAKNAIKLNNYEIRNGRLLGVCASVDNC-----------------RLFVGGIPKTKKREEILSEMKKVTEGVVDVIVSAADKTKNRGFAFVEYESHRAAAMARRKLLPGRIQGHGIAVDWAEPEVESVKILYVRNLMLSTSEEMIEKEFNNIKPGAVERKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRY............. 312
20 -45.900[A] KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1  ali follow..  18  3..............................................................................................................TTVSTGATAVATLRETSPPVDGHEEARLNADGSHGSQDPGKMFIGGLSWQTTAENLRDYFGRFGEVNECMVMRDPATKRARGFGFITFVDPSSVDKVLNNREHELDGKKIDPKVAFPKRTQAKLVTKT--------KKVFIGGLSATSTLEDMKQYFETYGKVEDAMLMFDKATQRHRGFGFVTFDSDEVADKVCEI-HFHEINGKMVECKKAQPKEVMLPV............................................................................................ 218
21 -45.300[R] KOG0110 RNA-binding protein (RRM superfamily)  ali follow..  13  205...................EEDTDKLAEKPISDLEYMKSLMATTSGEATAKKPKAKADKSNLELFTIKIHNVPYNTKRQEVLKFFKPLKPY------SVRLPSKVHGFCYVGFKTEKDMAKGPAAVDAGNAKWKHQQDSLSKEDDISESGRIFFRNLAYTTTEEDLRKLFEQFGPVVEVNLPLDKLTRKIKGFGTVTYMMPEHALKAFNLDGTDFHGRLLHLLPSKDIEKNPKEDLDENDASLRSNTVILAKNLPAATEISEITPIFSRFGPIGRIVL------PPSGVTALIEYCDPLEARQAFKKLAYSKFKNAPLYLEWAPEQPEPNTTLFLRNLNFKTVQETVEKHFRHLGSIHTREFKSLGYGFIQFKKSSVAEHALKNLQLTHIDGNPVELKRSDRASQKKQTGTKILVRNI...... 792
22 -45.200[R] KOG0125 Ataxin 2-binding protein (RRM superfamily)  ali follow..  19  3..................................................................................................................................KKKMVTQGNQEPTTTPDAMVQPFTTIPFPPPPQNGI----TEYGVPHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTNGSLTQTEGGAQTDGQQSQTQSSEN-----SESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNE--RGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKK............................................................................................ 195
23 -43.900[A] KOG4206 Spliceosomal protein snRNP-U1A/U2B  ali follow..  21  3..............................................................................................................................................TADIPPNQSIYIQNLNERIKKEELKRLFSQFGRILDVVALK---TPKLRGQAWVTFSEVTAAGHAVRMQNFPFYDKPMRLQYAKAKSDCLAKAEGTGQETMPPNNILFIQNLPHETTSMMLQLLFEQYPGFKEIRMIDA-----KPGIAFVEYEDDVQASIAMQPLQGFKITPQPMVISFAKK................................................................................................... 232
24 -43.300[J] KOG0122 Translation initiation factor 3, subunit g (eIF-3g)  ali follow..  16  47......................................................................................KFNDEENKVKITTRTRVRKLASARLNKRAMERRNWPKFGDAANEEAGSHLTMVSTEEILLERPRAPGTKADESKATGDGLSQLGKGGAVLMVCRICHKKGDHWTSKCPYKDLAAPTDVFIDKPPTGESSTMSAAPGTGKAARAGADRSAVGSDMRRRNDENSVRVTNLSEDTREPDLMELFHPFGAVTRVYVAIDQKTGVSRGFGFVNFVSREDAQRAINKLNGYGYDNLILRVEWATPRPT................................................................................................ 294
25 -42.000[D] KOG4660 Protein Mei2, essential for commitment to meiosis, and related proteins  ali follow..  12  28......TGYRSSSDLSMFSSSLPTLFHEKLNMTDSDSWLSFDESSPNLNKLVIGNSEKDSLEDVEPDALEILLPEDENELLPGLIDELNFTGLPDELDDLEECDVFCTGGGMELDVESQDNHAVDASPRKRPNTAGRVSVEHPNGEHPSRTLFVRNINSSVEDSELSALFEPFGEIRSLYT-----ACKSRGFVMISYYDIRAAHAAMRLQNTLLRKRTLDIHFSIPKENPSEKDMNQ--------GTLVIFNVDTTVSNDELLQLFGAYGEIREIR-----ETPNRRFHRFIEYYDVRDAETALKALNRSEIGGKCIKLELSRPGGARRLSVPSQSQDLE................................................................................... 359
26 -40.400[AR] KOG1365 RNA-binding protein Fusilli, contains RRM domain  ali follow..  11  130.................IEDDVAIARAILDMDDELLEKTHQFVNIEYQPAPILEDQEVGADGDNVVCRARGLPWQASDHHVAQFFAGLDIVPGGIALCLSSEGRRNGEVLVQFSSQESRDLALKRHRNFLLSRYIESSTEAMEFVSANAIIVRMRGLPYDCTDAQIRTFFEPLKLTDKILFITRT-DGRPTGDAFVQFETEEDAQQGLLKHRQVIGQRYIELFKSTAAEVQQAVANAVEAPEEKKKDCVRLRGLPYEATVQHIVTFLGDFATMVGVHMVYNN-QGHPSGEAFIQMINEQAASACAAGVHNNFMSKRYIEVFQASAEEGQVTQLIIYGIHMSIGVPELVANFTTPEHTVDNTHLCPGEAILTLRNRGAPPPQTSPLSQISQLSAPNFAAYSHHPQNFPL-----------QPILM 613
27 -39.800[R] KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains  ali follow..  13  89..............TTPATQPEISIPRSGENKSSRSPSWAREARRSRSRSRDRRGGRSRSRSPSRRRTSRDRRDDRSSRRRRDRSHSRSRSPPSSANGSSHWSSSNRHSRRRRSRSYSRERDRNSRRDDRRSNLSNNDRYSDWNPGVPSNKLAILNMPNDVDNTKITLSLGKCGYLVRTMTKFDKNTKQIRTFAFVEFSNRETAEQWMTDYEGWLDGRTLAVEYAKGDPAAGSGNKGDHMVGMTPCDTLLIRGLPDGINNSLIFDSLGALVCLSSISMIK---LSESKRFAYLQMKSADEAKMLLNLTYKIRIKDKDVQVSWCRDS.................................................................................................. 441
28 -39.700[A] KOG4209 Splicing factor RNPS1, SR protein superfamily  ali follow..  17  1.........................................................................................................................................................................MSDNDIIDDDVLNIEDMTGDDADLSAIELNEIEEEQKKLKAIQNEMVGHMNLNTSSQSNSSQSLLTPEE--KAEADAKSVYVGNVDYGATAEEIEQHFHGCGSVSRVTIQCDRFSGHPKGFAYVEFTEKEGMQNALA-MTDSLLRGRQIKVDPKRTNKPGMST............................................................................................ 162
29 -38.200[A] KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily)  ali follow..  16  11..................................................................................................................................RDQHFKGSRSEQERSLRDSCTLYVGNLSFYTTEEQIHELFSRCGDVRVIVMGLDKYKKTPCGFCFVEYYVRSEAEAAMRVNGTRLDDRLIRVDWDAGFVEGRQY------------GRGKTGGQVRDEYRTDYDAGRGGYGKLLSQKIAPNTDN............................................................................................................................................ 153
30 -37.700[A] KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins  ali follow..  15  4.........................................................GTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGITLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMASTTGHCVHMRGLPYRATENDIYNFFSPLN-PVRVHIEIGP-DGRVTGEADVEFATHEDAVAAMSK-DKANMQHRYVELFLNSTAGASGG............................................................................................. 370
31 -37.700[A] KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily)  ali follow..  19  2.....................................................................................................................................................VRVYIGRLPNRASDRDVEHFFRGYGKLSDVIM--------KNGFGFVDFQDQRDADDAVDLNGKELCGERVILEFPRRKVGYNEERSGSGFRGRSTRFRLVIDNLSTRYSWQDIKDHIRKLGIEPTY----SEAHKRNVNQAIVCFTSHDDLRDAMNKLQGEDLNGRKLKCTDETRDRSRSRS............................................................................................ 193
32 -36.100[J] KOG0129 Predicted RNA-binding protein (RRM superfamily)  ali follow..  13  329.......................NSISPLKKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDTIKARTYGRRRGQSSLFPMEDGFLDDGRGDQPLHSGLGSPHCFSHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAKSYFPPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISA-RFVQLQHGEIDKRVEVKP.................................................................................................. 642
33 -36.000[K] KOG1548 Transcription elongation factor TAT-SF1  ali follow..  14  75..................................................................................................................KRLYESTSAEGYPSGSRNKKSKSENSEASPAPVINKAVYIQGLPLDVTVDEIEEVFKKCGVIAKNIDNGTTEDGTPKGDALIVFFRSESVELAEQFDDTEFRYGSGQKMRVQKANIDYKKEKTVNKDVGGALKKVVLKHI-LIDLKDDITEEAEKCGRVTNVVLYDK----EPDGVVTVRFSNNEEAEACVRLMQGRYFDGRVVEASIYDGKVRFQKS----GKHTLDDEEDEEKRLEKFADWLENSN.............................................................. 367
34 -35.200[R] KOG0130 RNA-binding protein RBM8/Tsunagi (RRM superfamily)  ali follow..  22  17......................................................................................................................................................................................................EDGDQGIVRLKEKAKHRKGRGFGSDSNTREAIHSDDELEPGPQRSVEGWILFVTSIHEEAQEDEIQEKFCDYGEIKNIHLNLDRRTGFSKGYALVEYETHKQALAAKEALNGAEIMGQTIQVDWCFVKGPKRVK............................................................................................ 158
35 -35.000[R] KOG0149 Predicted RNA-binding protein SEB4 (RRM superfamily)  ali follow..  16  6...................................................................................................................................VPGSGFHYLNSPFGDTTFTKVFVGGLAWETQSETLRQHFEQYGEILEAVVIADKNTGRSKGYGFVTFRDPEAARRACADPTPIIDGRRANCNLASLGRPRPPLPYA----------VIPNMPDLLPRTLEMCRVLEVHLLEIIRISNHFHITTSKELSILMVTAYGPEYMYSQSQG..................................................................................................................... 171
36 -34.800[A] KOG1190 Polypyrimidine tract-binding protein  ali follow..  16  33...........................................................................................................................SNSASAANGNDSKKFKGDSRSAGVPSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLML------KGKNQAFIEMNTEEAANTMVNYTSVTPRGQPIYIQFSNHKELKTDSSPNQARAGQSPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTK----NNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTS............................................................................................... 262
37 -34.600[A] KOG0108 mRNA cleavage and polyadenylation factor I complex, subunit RNA15  ali follow..  29  2.................................................................................................................................................................................................................................................SMTAGNVVFVGNIPYDVSEQQMTEIFNQVGPVKTFKLVLDPETGSGKGYGFCEFFDSETTAMAVRKLNNSELGPRKIRVEFPSNDPRRNQS............................................................................................ 92
38 -33.100[A] KOG4207 Predicted splicing factor, SR protein superfamily  ali follow..  22  2..........................................................................................................................................................................................................................................SCGRPPPDVDGMITLKVDNLTYRTSPDSLRRVFEKYGRVGDVYIPLEPHTKAPRGFAFVRFHDRSDAQDAEAAMDGAVLDERELRVRMARYGRRDLPR............................................................................................ 99
39 -32.900[AR] KOG0109 RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains  ali follow..  17  166....................ATPRTLSGKWLTDEGRASSGCLNPNRCKPAPHAEGVGAGSRGGARAQSVLSPSGDSREGDLLQFASSERARLTPMIPRPRLLRIHGAFRTKRFSVRDKEDQWTVSRPSTEAGHNNKELPPPLPPRGACPDDEAVHQKPAPGHRAGDPLSFQAVGKVLECDII--------KNYGFVHIEDKTAAEDTIHLHHYKLHGVNINVEASKNKSKAS--------------TKLHVGNISPTCTNQELQAKFEKYGPVIECDIV--------KDYVLIHFIHMECCPQARLRTAPGMGDQCGCYQCKKEGHWSKECP............................................................................................ 456
40 -32.800[D] KOG2186 Cell growth-regulating nucleolar protein  ali follow..  13  166..........EQTLLAHANGKKHRVKVERFDAEQQKRQSTQHSTVDKKDYSKQQIEVDINVGLSNCTCQQNLLSHANGRKHRENVELFDATQQQQLEKTTVDKKDTTVNASDGNSEQKKVDLLVSSGVANGYSQAHKKRKLETCDETWKREVVQAEEAKGGGEQKSESKKAKKQDKEKKRKKDKKQTKSDSDFEHDKEDIKQLLVAYSKEELVNL------IYKTAEKGSRLISAILESADRDIAQRNIFVRGFGWDTTQENLKTAFESYGEIEECSVVMDKDTGRGKGYGFVMFKTRKGAREALKRPE-KRMYNRIVVCNLASEKPGKAGK............................................................................................ 492
41 -32.200[R] COG0724 RNA-binding proteins (RRM domain)  ali follow..  19  109.........................................................................................................................................................................CRLCGNDHMTMNCPFKTILSELSALEDPATNEGGVEAASEEKAGQVGGAGSIPGQYVPPSRRAGARDPSSDRERDDMCTLKIMQVNENADENSLRELLFPFAPIPRVSVVRNKETGKSRGLAFVTFSSEEVAEQALRFLDGRGYMNLILRVEWSKPKVKE............................................................................................... 274
42 -30.800[R] KOG0114 Predicted RNA-binding protein (RRM superfamily)  ali follow..  26  2.........................................................................................................................................................................................................................................NKRNHIRLPPEVNRLLYVRNLPYKITSDEMYDIFGKFGAIRQIRV---GNTPETRGTAFVVYEDIFDAKNACDHLSGFNVCNRYLVVLYYQSNKAFKRV............................................................................................ 97
43 -30.100[R] KOG4208 Nucleolar RNA-binding protein NIFK  ali follow..  17  2.................................................................................................................................................................................................................................................AAFSRSAGPILSLNP-QEDAELQKEVAQCDTVTRFRLSRKKRTGNSKGYAFVEFESEDVAKIVTETMNSYLFGERLLECHFMPPEKKMES............................................................................................. 90
44 -29.300[R] KOG4454 RNA binding protein (RRM superfamily)  ali follow..  17  1..........................................................................................................................................................................................................................................MEIKPTPSPPEERTIYVANFSEEVDEELLEELFIQAGPVVKVILRDV--RDSNAKFALVEFEDELSVLFAIELMNGVRLFNQELQVKPRNGTNQEE.............................................................................................. 94
45 -28.400[A] KOG0107 Alternative splicing factor SRp20/9G8 (RRM superfamily)  ali follow..  29  2......................................................................................................................................................................................................................................................SRVYVGNLDPRVTERELEDEFRSFGVIRSVWVARR-----PPGYAFLDFEDSRDARDAIREVDGKNGWRVEQSHNRGGGGGRGGGR............................................................................................ 82
46 -25.700[R] KOG4307 RNA binding protein RBM12/SWAN  ali follow..  13  479TVFGPGGIHMHTIIR--LDSIADYATMMRRNGEQGIKIQQSDKKSFDTAIDGIPIPSVSMVPSKEQRSHEDDDKKSRRSRWENTSPIRSPRRSPLRRDNRDRSRSRS--------------------PPRRRRRSRSPRRREEHTDPTRWCVQVTNVPFRMKDEELLEWFSEKVRPAKLTRTFYSD-GNASDRWVAEFSSESLMKRSFGIRTL-CTGRTLRLRYIDNAKADEILKIEDVYGEGKRQMNLSCNGFPKDVTLEDVVEFFNDYE--NSIRIRRGDD-GVMTGECMLACQNQENARRASMDLDGQKLRNSVISV........................................................................................................ 945
47 -25.400[R] KOG0126 Predicted RNA-binding protein (RRM superfamily)  ali follow..  26  12..............................................................................................................................................................................................................................ELNEREVQLGVADKVSWHSEYKDSAWIFLGGLPYELTEGDIICVFSQYGEIVNINLVRDKKTGKSKGFCFLCYEDQRSTILAVDNFNGIKIKGRTIRVDHVSNYRAPK.............................................................................................. 119
48 -24.400[R] KOG1457 RNA binding protein (contains RRM repeats)  ali follow..  15  12........................................................................................................................................................................................GSTGTGSGAGSGGALEEEPQNLGFRGQSCELEAGIHRGIIQWDHPDTVSVLFVHELKTRPGVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLIKLTA----RQPVGFVIFDSRAGAEAAKNALNGIRFDPQTLRLEFAKANTKMAKS............................................................................................ 177
49 -22.200[R] KOG0153 Predicted RNA-binding protein (RRM superfamily)  ali follow..  13  85....DLEYGLPIQVRDAALKVADNMPQSDVNKEYYIQNIDAQLQDGDGTEAAGAVGRSLAANEMLSKLARTAPYYKRNRPHICSFWVKGECKRGEECPYRHDKPNEPDDPLCEQNIKDRYYGRNDPVAEKIMKRAASLPTLEPPEDRNITTLYVGNLPEEITEPELRDQFYQFGEIRSIALVPR------QQCAFVQYTKRNAAELAAEFNKLVIQGRKVSIKWAHSQAKQGTAAKTDRRFDLA.................................................................................................................................................................................... 320
50 -22.000[R] KOG0151 Predicted splicing regulator, contains RRM, SWAP and RPR domains  ali follow..  13  16...............................................................................................................RSRNTEKKKKPRRRERRMKQLVCIKSPWNRFKGIMLQLRLINPNDNKLKPDSQGMFPPFVKDQRIRDEERSKEMEKGKTRNIHFVEELKREQEIRERRSRDHNSDNTSSSRFDELPDYFDPSGRLGSLDDGDPQTTNLYVVNLSSKVDENFLLRTFGRFGPIASVKIMTEEEKRRERHCGFVAFMNRADGEAAKEKMQGIIVYEYELKIGWGKVVFLPSQ............................................................................................. 258
51 -21.700[A] KOG0533 RRM motif-containing protein  ali follow..  15  54..................................................................................................................................................................................................................................KDLDAVQNHGISSRGNDSKVIRVNISNLAPTVISSDLEELFGDYR-LSSVSVNFNE-HGDSLGTGDISLTK-RDAERLVQKFSGVALDGKIMKFAVIDSSNMAGR............................................................................................. 155
52 -21.400[K] KOG4661 Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B)  ali follow..  12  275..................SESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINLHKTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSS................................................................................................................................................................................ 505
53 -18.900[R] KOG2135 Proteins containing the RNA recognition motif  ali follow..  13  334.....................................................................................................................GSFRGAPRGRGNIRGRGGFARGGFTGAINRDNCTLQVAKIPPENTIAKLNEHFATFGTVDNIQVRYNGEIDS----ALVTYASKFDAGKAYKSPTPVLNNRFIKVFWHNPGGEGSENATGKPSSPTSPSSVVIVRGVTDE-LVTDLMAHMEKFGEVFDHSVKADDDGLIT---AVFPFRKTGDALKAMA--DGKVLNGVDLEMELKTERIEEIPSTDTNMSADQLLAAI.............................................................................. 704
54 -18.800[R] KOG1995 Conserved Zn-finger protein  ali follow..  20  258................................................................................................................................................................................................................................YEDAATEKVKQCDADCDDNCDNARIYISNLPPDVTTDELKDLFGGIGQVGNIKIYTD-EKGNYKGDACLAYEDPSAAHSAGGFFNNYEMRGNKISVTMAEKSAPRAPT............................................................................................ 378
55 -18.400[A] KOG4849 mRNA cleavage factor I subunit/CPSF subunit  ali follow..  12  1MADVVLDLYAEDLDKDFAGQAQDEFGGDGVDLYDDIGGPTESAASGGGGGGTPSADGAAGPGSGEP---------------------------------------------------------GERNSGGPNGVYHQSSGSLTPTMNRRYQLYVGNLTWWTTDQDIANSLRDIGDLQEVKFFENRANGQSKGFSVISLGSESSLRAVLDLPKKEMHGQAPVVTYPSKQALTQFESLQKTRPVPPPQQN................................................................................................................................................................................ 194
56 -17.900[A] KOG1996 mRNA splicing factor  ali follow..  15  98...DEYDPMFPNDYEKVVKRQREERQRQRELERQKEIEEREKRRKDRHEASGFSRRPDPDSDEDEDYERERRKRSMGGAAI---------------------------------APPTSLVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEPDRPRSPTGPSNSFLANMGGTVAHKIMQKYGFREGQGLG----KHEQGLSTALSVEKTSKRGGKIIVGDATEKGEAQDASKKSDSNPLTEILKVLLRNMAGEVDEDETKEECEKYGKVGKCVIFEIPGAPDDEVRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFYNLDK................................................................................................. 395
57 -17.800[T] KOG0116 RasGAP SH3 binding protein rasputin, contains NTF2 and RRM domains  ali follow..  10  124VLNDVFDEIVEPEANKKEVEEVIPQVVQPTEQVDEVAEPVTIPTQQPEAKQTTENTVKKPERAVANGHPKTQEDNVVNDKSNGVDAPKKSFAHIVQDLAQNGATFNAKASPAKPKSKPVTKPSAARESKAPAPVSEHSSAATIDQQAEGYTIFVANLLMDATPEQLNETFKGFGAITKDGIQVRSYRLKGNCFGFVTFASAEAVKLVLQESAIRIGNRRVSIEEKRGNNDNGRPAMRNGGYRNDNGYR................................................................................................................................................................................ 378
58 -17.600[K] KOG2068 MOT2 transcription factor  ali follow..  12  1.............................................................................................................................................MSDYGEKTCPLCAEEM--DLTDQQLKPCKCGYQICVWCHIMDMAEKDQSEG----PYDKEKIVGMTVDQERLASEGNMDRKKIQKSKPKSSDGRKPLTSVRVVQRNLVYIVGLPLNLADEDLKEYFGQYGKVLKVSMSRTQQFPNNTCSVYITYGKEEEAIRCIQSVHGFILDGKALKACFGTTK.................................................................................................. 196
59 -17.000[K] KOG3152 TBP-binding protein, activator of basal transcription (contains rrm motif)  ali follow..  18  1.....................................................................................................................................................................................................MQSEESHELTDGISEEKESKETMKSQKADRKKKKLKEKLLKEASKADNRGVCYLSRIPPHMDHVRLRHILAQYGELGRIYLAAGGFRGQRFSEGWVEFAKKSVAKRVADMLNGEQIGGKKKS......................................................................................................... 143
60 -15.100[TR] KOG4019 Calcineurin-mediated signaling pathway inhibitor DSCR1  ali follow..  17  2.............................................................................................................................................................................................................................................EEVDLQDLPSATIACHLDPRVFVAKFESLFRTYDKDITFQYF------KSFKRVRINFSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQ................................................................................... 104
61 -15.100[R] KOG2295 C2H2 Zn-finger protein  ali follow..  10  367.KKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVVETETIDLDKVKDGQPRALHRTSSIFLRNLAPSITRSEIEAVCNRFSGYLRVAIADPLVERRWYRRGWITFMRDVNIKEICGLNNQRLRDCEMGAIVNRDLSRRVRPANGITAHKQVVRSDI-CAKIALNLDEK................................................................................................................................................................... 628
62 -14.400[A] KOG0113 U1 small nuclear ribonucleoprotein (RRM superfamily)  ali follow..  26  98..................................................................................................................................................................................................................................................EDPFRTLFIARINYDTSESKLRREFEFYGPIKKIVLIHDQESGKPKGYAFIEYEHERDMHAAYKHADGKKIDSKRVLVDVERARTVKG.............................................................................................. 185
63 -14.100[A] KOG2202 U2 snRNP splicing factor, small subunit, and related proteins  ali follow..  22  77..............................................................................................................................................................................................................................................................HFEDFFEDLFEELGKFGEIESLNICDNL-ADHMIGNVYVQFKEEDQAAAALQALQGRFYSGRPIIADFSPVTD................................................................................................. 148
64 -13.000[A] KOG4676 Splicing factor, arginine/serine-rich  ali follow..  16  26..............................................................................................................................................GGGGGGTEVIQVTNVSPSASSEQMRTLFGFLGKIDELRLFDDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAE..................................................................................................................................................................................................... 112
65 -12.600[A] KOG4213 RNA-binding protein La  ali follow..  17  12...........................................................................................................................................................ALEAKICHQ-IEYYFG------DFNLPRDKQIKLDEGW-MIKFNDFNVIVEALSKSKAEL----MEISEDKTKIRRSPSKPTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLH-KAFKGSIFVVFDSIESAKKFVETPG................................................................................................................... 172
66 -12.200[R] KOG4198 RNA-binding Ran Zn-finger protein and related proteins  ali follow..  14  227....................................................................................................................................QPINCQADARSFYAERSKIVHVAGLTNDVTQLELESWFTNHGHPVALWTLKTPEPYKSTGTGFVLFASHEDAADALAFNGYCLGDRMLEIIPSSTKVLDKASDILIPFPSSKNRPR------DWNCPMCGFSN-FQRRTSCFRCSFPGPTHVSAATG....................................................................................................................................... 379
67 -12.100[J] KOG2314 Translation initiation factor 3, subunit b (eIF-3b)  ali follow..  18  1..................................................................................................................................................................................................MAAVVDIDVLTAQLGINWSDVNLDSIQLPPGNESDDESVYQDDQSEFDTGFGNIIVVDHLP--VPKEKVKKIYNQLGVIKGLLMPVDPDTKMTLGYCFIEFNTPQEAQNAKEKSHGYKLDKS............................................................................................................ 134
68 -12.000[R] KOG1855 Predicted RNA-binding protein  ali follow..  18  280...........................................................................................................................................................ELAAEITDA-VEFYFS------NESILKDKHVRRNK--GFVSFKRVRQLTREWKVVGDAVRRKSRKIELNDVGTKVRRIEPLPSFDETMPSRTIVACDLPLDLTIEKVSDLFSPCGEIALIRILKPGMAIPVKECALVEYLESSSARDARHLNG................................................................................................................... 450
69 -11.300[K] COG5175 Transcriptional repressor  ali follow..  14  8............................................................................................................................ENLQAIHNALSNFDTSFLSEDEEDYCPLCIEPM--DITDKNIRQNPELNGRCPACRRKYDDEN--------VRYVTLSPEELKMERAKLARKEKERKHREKERKENEYTNRKHLSGTRVIQKNLVYVVGINPPVPYEEVEKYFGQYGKINKIVVNRYHHHSPGYG-VYITFGSKDDAARCIAQVDGTYMDGRLIKAAYGTTK.................................................................................................. 233
70 -10.600[O] KOG0111 Cyclophilin-type peptidyl-prolyl cis-trans isomerase  ali follow..  19  2.................................................................................................................................................ATTKRVLYVGGLAEEVDDKVLHAAFIPFGDITDIQIPLDYETEKHRGFAFVEFELAEDAAAAINMNESELFGRTIRVNLAKPMRKAETQEGEPIAKKARSNPQVYAGRIQMLLRSDVVPMTAENFRCLCT-RIIPDFTNHNGTGYG--NFILKHTGPGLLSMANGPNTNGSQFFLTCDK.................................................................................................... 254
71 -10.100[A] KOG4008 rRNA processing protein RRP7  ali follow..  10  38.............................................................................................................................................LKKDPSKENSIIVSNIPAFVGEGVVLAIIDQFASFEVEESFVDNSLSQGQLTMSITFDKPEAVIQTLALCQDVGPFTITDFLEDPEFPSVLKDSTTLYRKLFPSEEQIYVERYDTEQTEARKYSEPDEDGWITVTK-GGLNNKKKKVDLAYYTFQIKKNRQEKAQELKKFEEDRKRITQLKQARN.................................................................................................. 257
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;