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Query: [R] KOG0153 Predicted RNA-binding protein (RRM superfamily), from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSKTTNTYNRQNWEDAEFPILCQTCLGDNPYVRMIKERFGKECKICTRPFTIFRWCPGARMRFKKTEICQTCARLKNVCQTCLLDLEYGLPIQVRDAALKVADNMPQSDVNKEYYIQNIDAQLQDGDGTEAAGAVGRSLAANEMLSKLARTAPYYKRNRPHICSFWVKGECKRGEECPYRHDKPNEPDDPLCEQNIKDRYYGRNDPVAEKIMKRAASLPTLEPPEDRNITTLYVGNLPEEITEPELRDQFYQFGEIRSIALVPRQQCAFVQYTKRNAAELAAERTFNKLVIQGRKVSIKWAHSQAKQGTAAKTDRRFDLAGIPPPSAKPNDYFNLRQEQINVMPAGMKLHQLPSNLVPASAYQMYGQPTYAAPYGNATSTALSSSGVNLDSISIPPPPGQVPYPSQDASRMGAVKKLast
1 -139.000[R] KOG0153 Predicted RNA-binding protein (RRM superfamily)  ali  100  1MSKTTNTYNRQNWEDAEFPILCQTCLGDNPYVRMIKERFGKECKICTRPFTIFRWCPGARMRFKKTEICQTCARLKNVCQTCLLDLEYGLPIQVRDAALKVADNMPQSDVNKEYYIQNIDAQLQDGDGTEAAGAVGRSLAANEMLSKLARTAPYYKRNRPHICSFWVKGECKRGEECPYRHDKPNEPDDPLCEQNIKDRYYGRNDPVAEKIMKRAASLPTLEPPEDRNITTLYVGNLPEEITEPELRDQFYQFGEIRSIALVPRQQCAFVQYTKRNAAELAAERTFNKLVIQGRKVSIKWAHSQAKQGTAAKTDRRFDLAGIPPPSAKPNDYFNLRQEQINVMPAGMKLHQLPSNLVPASAYQMYGQPTYAAPYGNATSTALSSSGVNLDSISIPPPPGQVPYPSQDASRMGAVKK 416
2 -34.100[R] KOG0226 RNA-binding proteins  ali follow..  9  109.......................................................................................................................................AAPIMFPPRVLGIPAPATIEGAPALYETPAVNAIPQELLRTQALQSDIDKMNFKKQTDPFKKKIKEQQAKKKFVRSGGGQVWEDPSLAEWDENDFRVFCGDLGNEVSDELLAKAFRKYPSFQKAKVVREKGYGFVSFRDSEDYVRAMREM-DGKYVGNRPIKLRKSAWKERNIDVIKQKRKQKKE................................................................................................ 298
3 -32.200[J] KOG0899 Mitochondrial/chloroplast ribosomal protein S19  ali follow..  11  1......................................................................................................................................................MESRHFATALVFLASKGFVDILYWVYRFQASSMAFCTKL------------------GHWKQGVNVPVSSMLGSLRYMSTKLYIGGLSPGTDEHSLKDAFSSFNGVTEARVMTNRGYGFVNFISEDSANSAISAM-NGQELNGFNISVNVAKDWPSLPLSLDE....................................................................................................... 151
4 -31.500[J] KOG0122 Translation initiation factor 3, subunit g (eIF-3g)  ali follow..  12  1MTIDSQKTSKFRWGEMDLPPKQVIGPDEN--LKTTIEYKFND----------------EENKVKITTRTRVRKLASA-------RLNKRAMERRNWPKFGDAANEEAGSHLTMVSTEEILLERPRAPGTKADESKATGDGLSQLGKGGAVLMVCRICHKKGDHWTSKCPYKDLAAPTDVFIDKPPTGESSTMSAAPGTGKAAYVPPSMRA--GADRSAVGSDMRRRNDENSVRVTNLSEDTREPDLMELFHPFGAVTRVYVAIDRGFGFVNFVSREDAQRAINKL-NGYGYDNLILRVEWATPRPT.............................................................................................................. 294
5 -31.200[AJ] KOG0148 Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily)  ali follow..  12  8............................TLYVGNLSRDVTEA--------QLF-------SQIGPCKNCKMIMDTAGNDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSNHFHGDLSPQITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRFNSHESAAHAIVSV-NGTTIEGHVVKCYWGKETLDMINPVQQQNQ.................................................................................................... 288
6 -29.900[R] KOG0125 Ataxin 2-binding protein (RRM superfamily)  ali follow..  15  65......................................................................................................................................................................................TQAHGEQSSNSPSTQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNKGFGFVTFENSADADRAREKL-HGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYP...... 295
7 -29.700[A] KOG0108 mRNA cleavage and polyadenylation factor I complex, subunit RNA15  ali follow..  17  2................................................................................................................................................................................................................................SMTAGNVVFVGNIPYDVSEQQMTEIFNQVGPVKTFKLVSGKGYGFCEFFDSETTAMAVRKL-NNSELGPRKIRVEFPSNDPRRNQSYEYTER.................................................................................................... 98
8 -29.100[R] KOG4454 RNA binding protein (RRM superfamily)  ali follow..  19  1.........................................................................................................................................................................................................................MEIKPTPSPPEERTIYVANFSEEVDEELLEELFIQAGPVVKVILRDVAKFALVEFEDELSVLFAIELM-NGVRLFNQELQVKPRNGTNQEELYKRK....................................................................................................... 99
9 -29.000[R] COG0724 RNA-binding proteins (RRM domain)  ali follow..  12  1.........................MSEVAPEEIIENADGSR--------SIITYKIEDGVKYKITQKVKEVKVLEKVHKSVAERKNWH---KYGSEKGSPAGPSAVTARLGEEVELRLSRNWKQAEEERIQKEKASLTKTGLQCRLCGNDHMTMNCPFKTILSELSALEDPATNEGGVEAASEEKAGQVGGAGSIPGQYVPPS---RRAGARDPSSDAYRDSRERDDMCTLKIMQVNENADENSLRELLFPFAPIPRVSVVRNRGLAFVTFSSEEVAEQALRFL-DGRGYMNLILRVEWSKPKVKE............................................................................................................. 274
10 -28.800[A] KOG4207 Predicted splicing factor, SR protein superfamily  ali follow..  21  6.............................................................................................................................................................................................................................PPPDVDGMITLKVDNLTYRTSPDSLRRVFEKYGRVGDVYIPLERGFAFVRFHDRSDAQDAEAAM-DGAVLDERELRVRMARYGRRDLPRSSQ....................................................................................................... 102
11 -27.800[A] KOG0107 Alternative splicing factor SRp20/9G8 (RRM superfamily)  ali follow..  27  1....................................................................................................................................................................................................................................MSRVYVGNLDPRVTERELEDEFRSFGVIRSVWVARRPGYAFLDFEDSRDARDAIREV-DGKNGWRVEQSHNRGGGGGRGGGRGGGDGG.................................................................................................... 88
12 -27.400[A] KOG0145 RNA-binding protein ELAV/HU (RRM superfamily)  ali follow..  11  55..........QNMTQEEFRSLFGS-IGEIESCKLVRDKITGQSL-----FVNYI---------DPKDAEKAINTLNGL--------------RLQTKTIKVSYARPSSASIRDANLY------------SGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKSSQGMTSLVGMNIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDKGFGFVTMTNYDEAAMAIASL-NGYRLGDRVLQVSFKTNKAHKS............................................................................................................ 380
13 -27.400[R] KOG1457 RNA binding protein (contains RRM repeats)  ali follow..  13  85.............................................................................................................................................................................................................................ELKTRPGVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLIKARQPVGFVIFDSRAGAEAAKNAL-NGIRFDPENLRLEFAKANTKMAKSKLMATPNPSNAWAPYPLYTTELTPAISHAAFTYPTATAAAAALHAQRRHIRQCTPTCRIEKLMLKGLVTGEVVLVTAPRLTPSPESQSCTGRLGSKMSVLVNASAG 283
14 -27.300[A] KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily)  ali follow..  25  18.........................................................................................................................................................................................................................SRSEQERSLRDSCTLYVGNLSFYTTEEQIHELFSRCGDVRVIVMGLDCGFCFVEYYVRSEAEAAMRFV-NGTRLDDRLIRVDWDAGFVEGRQYGR........................................................................................................ 117
15 -27.000[R] KOG0130 RNA-binding protein RBM8/Tsunagi (RRM superfamily)  ali follow..  22  45.........................................................................................................................................................................................................REAIHSYERVRNEDDDELEPGPQRSVEGWILFVTSIHEEAQEDEIQEKFCDYGEIKNIHLNLDKGYALVEYETHKQALAAKEAL-NGAEIMGQTIQVDWCFVKGPKRVKKSEKRRR................................................................................................... 165
16 -26.700[A] KOG4209 Splicing factor RNPS1, SR protein superfamily  ali follow..  15  30.....................................................................................................................................................................................DLNEIEEEQKKLKAIQNEMVGHMNLNTSSQSNSSQSLLTPEEKAEADAKSVYVGNVDYGATAEEIEQHFHGCGSVSRVTIQCDKGFAYVEFTEKEGMQNALA--MTDSLLRGRQIKVDPKRTNKPGMSTTNR....................................................................................................... 165
17 -26.500[D] KOG2186 Cell growth-regulating nucleolar protein  ali follow..  15  4.................F--QCDDC-GEN--LKKPRPRHMSMCTACIDCGNMFGQVSVHYHNFNSQWFCSLC-NATMTCEQDYFAHVYGKKHQEKANEVADMDYSKQQSEHLAHANGKKHRVKVERFDAEQQKRQSTQHSTVDKKDYSKQQIEVDINVGLSNCYPWFCSLCNVKATCQ-SHANGRKHRENVELFDATQQQQLEKTTVDKKDTTVNASDGNSEADRDIAQRNIFVRGFGWDTTQENLKTAFESYGEIEECSVVRGKGYGFVMFKTRKGAREALKRPEK--RMYNRIVVCNLASEKPGKAGKEQD....................................................................................................... 495
18 -26.300[A] KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily)  ali follow..  15  1....................................................................................................................................................................................................................................MVRVYIGRLPNRASDRDVEHFFRGYGKLSDVIM--KNGFGFVDFQDQRDADDAVHDL-NGKELCGERVILEFPRRKVGYNEERSGSGF.................................................................................................... 85
19 -25.800[R] KOG0114 Predicted RNA-binding protein (RRM superfamily)  ali follow..  24  2........................................................................................................................................................................................................................NKRNHIRLPPEVNRLLYVRNLPYKITSDEMYDIFGKFGAIRQIRVGETRGTAFVVYEDIFDAKNACDHL-SGFNVCNRYLVVLYYQSNKAFKRVDMDKKQEELN................................................................................................ 107
20 -25.700[A] KOG0105 Alternative splicing factor ASF/SF2 (RRM superfamily)  ali follow..  27  6.............................................................................................................................................................................................................................DERGGEGDGRIYVGNLPTDVREKDLEDLFYKYGRIREIELKNRVPFAFVRFEDPRDAEDAIYGR-NGYDYGQCRLRVEFPRTYGGRGGWPRGGRN.................................................................................................... 102
21 -25.600[R] KOG0110 RNA-binding protein (RRM superfamily)  ali follow..  15  536.GVRLDAFDEPAKKRSNTVILAKNL--EISEITPIFSRFGPRIVL-SGVTALIEYC-------DPLEARQAFKKLAYS----PLYLEWAPEQVFTKTLSGEPVIPKSEPKPKEEVKPEEKPIVNDAKPDEEDSRAEDADDEPEPNTTLFLRNLNFKTVQETVEKHFRHGFIQFKKSSVAEHALKNLQLTHIDGNPVELKRSDRVLKTQDND----GAQRRLASQKKQTGTKILVRNIPFQAQYREVRDIFKAFGELRSLRIPKKRGFGFVDYMSKAEAKRAFDALSASTHLYGRRLVLEWSANDDNQDVEELRKRTAA.................................................................................................. 881
22 -25.500[A] KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily)  ali follow..  10  1MATATIALQVNGQAAAAVVAAGDK-PQGTDSIKMENGQSTAA----KLGLPPLTPE--QQEALQKAKKYAMEQSIKSVLVKQTIAHQQQQLTNLQMAAVTMGFGDPLSPLQSMAAQRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQMNSVMLGGRNIKVGRPSNIGQAQPII--------DQLAEEARAFNRIYVASVHQDLSDDDIKSVFEAFGKIKSCTLARDKGYGFIEYEKAQSSQDAVSSM-NLFDLGGQYLRVGKAVTPPMPLLTPATPGGLPPAAA.............................................................................................. 323
23 -24.700[AJ] KOG0123 Polyadenylate-binding protein (RRM superfamily)  ali follow..  12  1MNAAASSYPMASLYVGDLH-VTEAMLGPVLSIRVCRDMITRRSL-----YVNFQ---------QPADAERALDTMNF-------DVIKGKPIRIMWSQRDPSLRKSGVGN-------------------KNLDKSIDNKALYDTFSAFGNILSCKVVCDE---GSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKEREAEL-----------GAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDKGFGFVSYEKHEDANKAVEEM-NGKEISGKIIFVGRAQKKVERQAELKRKFEQLK................................................................................................. 284
24 -24.300[A] KOG0144 RNA-binding protein CUGBP1/BRUNO (RRM superfamily)  ali follow..  20  389.............................................................................................................................................................................................................................SQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKCFGFVSYDNPVSAQAAIQSM-NGFQIGMKRLKVQLKRSKNDSKP........................................................................................................... 481
25 -24.300[A] KOG4206 Spliceosomal protein snRNP-U1A/U2B  ali follow..  22  151..............................................................................................................................................................................................................................QETMPPNNILFIQNLPHETTSMMLQLLFEQYPGFKEIRMIDKPGIAFVEYEDDVQASIAMQPLQGFKITPQNPMVISFAKK................................................................................................................. 232
26 -24.100[A] KOG1190 Polypyrimidine tract-binding protein  ali follow..  11  11.................................................................................................................................................................................GTKRGSDELFSTCVTNGPFIMSSNSASAANGNDSKKFKGDSRSAGVP----SRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVTPLRGQPIYIQFSNHKELKTDSSPNQAR.................................................................................................... 146
27 -23.900[R] KOG0149 Predicted RNA-binding protein SEB4 (RRM superfamily)  ali follow..  24  16.............................................................................................................................................................................................................................SPFGDTTFTKVFVGGLAWETQSETLRQHFEQYGEILEAVVIRSKGYGFVTFRDPEAARRACAD--PTPIIDGRRANCNLASLGRPRPPLPYAV...................................................................................................... 112
28 -23.900[A] KOG0146 RNA-binding protein ETR-3 (RRM superfamily)  ali follow..  17  4...................................................................................................................................................................................KMATLANGQADNASLSTNGLGSSPGSAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDKGCAFLTYCERESALKAQSALHEQKTLPGRPIQVKPADSESRGGSSCLRQPPSQ.................................................................................................. 150
29 -23.900[R] KOG0118 FOG: RRM domain  ali follow..  18  159.......................................................................................................................................................................................................................NARTSMAQREDVIRRTVYVSDLDQQVTEEQLAGLFVSCGQVVDCRICGDLRFAFIEFTDEEGAMTALN--LSGTMLGFYPVKVLPSKTAIAPVNPTFLPRTEDER................................................................................................ 265
30 -23.700[A] KOG0131 Splicing factor 3b, subunit 4  ali follow..  14  1.........................................................................................MTTRIAPGVGANLLGQHSAERNQDATVY------------GGLDAQLSEELLWELFVQAGPVVNVYVPKDRVTNLHQNYGFIEYRSEEDADYAIKVLNMIKLHGKPIRVNKASQD------------------KKSLDVGANLFIGNLDPDVDEKLLYDTFSAFGVIASNPKINSRGFGFISYDSFEASDAAIESM-TGQYLSNRQITVSYAYKKDTKGERHGTPAE.................................................................................................... 204
31 -23.500[A] KOG4212 RNA-binding protein hnRNP-M  ali follow..  13  81...........DVKWQSLKDLVKEKVGEVTYVELLMDAEGK-----SRGCAVVEFK-------MEESMKKAAEVLNKHS--------SGRPLKVKEDPDGEHARRAMQKVMATTGG----------------------------------------------------------------------------MGMGPGGPGMITIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILKSRGIGTVTFEQSIEAVQAISMF-NGQLLFDRPMHVKMDERALPKGDFFPPERPQQLP................................................................................................ 298
32 -23.000[R] KOG4208 Nucleolar RNA-binding protein NIFK  ali follow..  17  2................................................................................................................................................................................................................................AAFSRSAGPILSLNP-QEDAELQKEVAQCDTVTRFRLSRKKGYAFVEFESEDVAKIVTETM-NSYLFGERLLECHFMPPEKKMESISKTNHR.................................................................................................... 97
33 -22.900[R] KOG0126 Predicted RNA-binding protein (RRM superfamily)  ali follow..  25  33..................................................................................................................................................................................................................................KDSAWIFLGGLPYELTEGDIICVFSQYGEIVNINLVRDKGFCFLCYEDQRSTILAVDNF-NGIKIKGRTIRVDHVSNYRAPKDSEEI....................................................................................................... 124
34 -22.900[A] KOG0115 RNA-binding protein p54nrb (RRM superfamily)  ali follow..  17  1.......................................................................................................MSGARRDNRRSNGRDDSSRVAKAENDRKPGRENRGGDEKRGNSNNAARSGGGGGGNRG--AERGIAPAQQPYDNNGGHRSGGGGGRSGGGGTSFNGAAFTESQLMDEV----------PKKKFTGRCRLFVGNLPNEVKETELKELFSPHGDIAECYLS-GKGFAFLRLDTRAHAESAKEAI-DGRIIHGRQVRVRFAVHGAA.............................................................................................................. 190
35 -22.200[K] KOG0147 Transcriptional coactivator CAPER (RRM superfamily)  ali follow..  13  5....................................................................................DFDIVIEAMLEAPYKKEEDEQQRKEVKKDYPSNTTSSTSNSGNETSGSSTIGETSNRSRDRDRYRRRNSRSRSPGRQCRHRSRSWDRRHGSESRSRDHRREDRVHYRSPPLATGYRYGHSKSPHFREKSPVREPVDNLSPEERDARTVFCMQLAARIRPRDLEDFFSAVGKVRDVRIISDKGIAYVEFCEIQSVPLAIG--LTGQRLLGVPIIVQASQAEKNRLAAMANNLQKGNG................................................................................................ 244
36 -22.100[A] KOG0128 RNA-binding protein SART3 (RRM superfamily)  ali follow..  12  640..........................................................................................................................................................................................ENDQKAQQALLKDRVPVKGRPMFISANDPEKRVGFKFSTTLEKSKVFVRNVHFQATDDELKALFSKFGTVTSVRRVTHKGIAFVDFDTEASAQKCVASG-DKLMLRERELEVALSNPPVKKDKSHGKPAAIGASLEEDGPRKGHAAKLQLVPRAITNKTPQITARLDAMDVSEGTSTSQPLSN............................................... 826
37 -21.500[A] KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily)  ali follow..  12  61.....GKLPRDLFEDELIPLCEK--IGKIYEMRMMMDFNGN-----NRGYAFVTFS-------NKVEAKNAIKQLNN--------------YEIRNGRLLGVCASVDNCR-------------------GGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFA-----------VEYESHRAAAMARRKLLPGRIQLWGHGIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNNIKPGAVERVKKIRDYAFVHFSNREDAVEAMKAL-NGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRGTMLQGEYTYSLGQVYDPTTTYLGAPVFYAPQTYAAIPSLHFPATKGHLSNRAIIRAPSVRGAAGVRGLGGRGYLAYTGLGRGYQVKGDKREDKL.. 414
38 -21.400[K] KOG4210 Nuclear localization sequence binding protein  ali follow..  18  217...............................................................................................................................................................................................................SENYSGRPDKDDLVAMSKNPPSRILFVGNLSFDVTDDLLRKHFQHCGDIVKIRMATFKGFAFIDFKNEEGSTNELKDK-SCRKIAGRPLRMEYGEDRSKRQVRKKVENVSR.................................................................................................. 332
39 -20.100[TR] KOG4019 Calcineurin-mediated signaling pathway inhibitor DSCR1  ali follow..  7  5...............................................................................................................................................................................................................................DLQDLPSATIACHLDPRVFVAKFESLFRTYDKDITFQYFKSFKRVRINFSNPFSAADARLQL-HKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQEKEEEEEMERMRRPKPKIIQTRRPEYTPIHLS.... 197
40 -20.000[R] KOG2135 Proteins containing the RNA recognition motif  ali follow..  14  1MHIDNEDALFD-WLSDELSPITDNALAK--YVALVKKPDKGH-AFTNEQLNVF-------TDHTAPFVDKVFEALTSKSYMPASTAPTSASATAPDLKKEKAPAEKPSKPTAPPGVQKSSSSPSASKAESRPLRKRISPPPSENREKEKQSRDKERRRSRS---FEERGYCIRGDQCPYYHGRDPPPAAAQGVVTQPGSFRGAPRGRGNIRGRGGFARGGFTGAINRDNCTLQVAKIPPENTIAKLNEHFATFGTVDNIQVRYNGDSALVTYASKFDAGKAYKS--PTPVLNNRFIKVFWHNPGGEGSENATGKPSSPTSPPKPVEKPKIATVQESKFVSVAAQNYRKQIQDAKERLTKE........................................................ 497
41 -20.000[A] KOG0120 Splicing factor U2AF, large subunit (RRM superfamily)  ali follow..  19  45.....................................................................................................................................................................................DVPPPGFEHITPMQYKAMQASGQIPASVVPDTPQTAVPVVGSTITRQARRLYVGNIPFGVTEEEMMEFFNQQMHLVGLAQAADKNFAFLEFRSIDETTQAMA--FDGINLKGQSLKIRRPHDYQPMPGITDT....................................................................................................... 185
42 -19.200[T] KOG0116 RasGAP SH3 binding protein rasputin, contains NTF2 and RRM domains  ali follow..  12  59LKAINEQIMSFDYEISKIQI-SQASYMNGVVTLVTGLLTVKE----RMRFSSFFLVPLNGSYFVLNDVFRYVADEIVEPEANKKEVEEVIPQVVQPTEQVDEVAEPVTIPTQQPEAKQTTENTVKKPERAVANGHPKTQEDNVVNDKSNGVDAPKKSFAH-------------IVQDLAQNGATFNAKASPAKPKSKPVTKPSAARESKAPAPVSEHSSAATIDQQAEGYTIFVANLLMDATPEQLNETFKGFGAITKDGIQKGNCFGFVTFASAEAVKLVLQAHESAIRIGNRRVSIEEKRGNNDNGRPAMR....................................................................................................... 367
43 -18.800[K] KOG2068 MOT2 transcription factor  ali follow..  12  2..............SDYGEKTCPLCAEE---MDLTDQQL-KPCK-CG-------------------QICVWC--------------------HIMDMAEKDQSEGRCPACRTPYDKEKIVGMTVDQERLASEGNMDRKKIQKSKPKSSDGRKPLTSVR---------------------------------------------------------------------QRNLVYIVGLPLNLADEDLKEYFGQYGKVLKVSMSRTAT-VYITYGKEEEAIRCIQSV-HGFILDGKALKACFGTTKYCHAWLRNVACNNQDCLYLHEVGSQEDSFTKDEIISAHTRVQQITGATNTMQYRSGSMLPPPLDAYTSDSSTGNPIAKVPSSTSVSAPKSSPPSGSSGKSTALPAAASWGAR 308
44 -18.700[R] KOG0151 Predicted splicing regulator, contains RRM, SWAP and RPR domains  ali follow..  16  1.................................MVKDE-------------FFLDHPGRKHRSRNTEKKKKPRRRERRMKQLVC---------IKSPWNRFKGIMLQLRLLLEVTINPNDNKLKPDSQGMFPPFSPHHWHLRVKDQRIRDEERSKEMEKGK-----TRNIDHFVEELKREQEIRERRNQDRENSRDHNSDNTSSSRFDEPDYFDPSGRLGSLDDGDPQTTNLYVVNLSSKVDENFLLRTFGRFGPIASVKIMRERHCGFVAFMNRADGEAAKEKM-QGIIVYEYELKIGWGKVVFLPSQA.......................................................................................................... 259
45 -18.500[R] KOG4733 FOG: RRM domain  ali follow..  11  1..............................................................MGKVWKQQMYPQYAT---YYYPQYLQAKQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTN-RGLPPHTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQ--------------------------QEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDRGVGFARMESTEKCEAVIGHF-NGKFIKTPPGVSAPTEPLLCKFADGGQKKRQ................................................................................................... 232
46 -18.100[K] KOG1548 Transcription elongation factor TAT-SF1  ali follow..  16  81........................................................................................................................................................................................................TSAEGYPSGSRNKKSKSENSEASPAPVINKAVYIQGLPLDVTVDEIEEVFKKCGVIAKIKIYRTKGDALIVFFRSESVELAEQ-LFDDTEFRYGSGQKMRVQKANIDYKKEKTVNK.................................................................................................... 208
47 -17.500[A] KOG2202 U2 snRNP splicing factor, small subunit, and related proteins  ali follow..  17  11...........................................................................................................................................................TEKDRVNCPFYFKGACRHGDRCSRLHNRPTISPTLLLSNMYQRPDMITPGVDAQGQ-----------PLDPRKIQEHF------EDFFEDLFEELGKFGEIESLNICDNLGNVYVQFKEEDQAAAALQAL-QGRFYSGRPIIADFSPVTDFREATCRQYEENN.................................................................................................. 161
48 -17.200[D] KOG4660 Protein Mei2, essential for commitment to meiosis, and related proteins  ali follow..  12  23.AFNGGTGYRSSSDLSMFSLFHEK-MTDSLSFDESSPNLNKL----VEPDALEILLPEDENEIDELNFTGLPDELDDLEECDVFCTGGGMELDVESQDNHAVDASGMQISDRGAANAFVPRKRPNTAGRVSVEHPNGEHPSRTLFVRNINSSVEDSELSALFEPFRGFVMISYYDIRAAHAAMRALQNTLLRKRTLDIHFSIPKENPSEK---------------DMNQGTLVIFNVDTTVSNDELLQLFGAYGEIREIRETNRRFHRFIEYYDVRDAETALKAL-NRSEIGGKCIKLELSRPGGARRLSVPSQSQ.................................................................................................... 356
49 -16.900[A] KOG0533 RRM motif-containing protein  ali follow..  13  66.............................................................................................................................................................................................................................SRGNDSKVIRVNISNLAPTVISSDLEELFGDYR-LSSVSVNDSLGTGDISL-TKRDAERLVQK-FSGVALDGKIMKFAVIDSSNMAGRV.......................................................................................................... 156
50 -16.400[A] KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1  ali follow..  15  9.................................................................................................................................................................................................ATAVATLRETSPPVDGHEEARLNADSDDGSHGSQDPGKMFIGGLSWQTTAENLRDYFGRFGEVNECMVMRARGFGFITFVDPSSVDKVLNN--REHELDGKKIDPKVAFPKRTQAKLVTKTKK.................................................................................................... 135
51 -16.300[A] KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins  ali follow..  14  4..............................................................................................................................................................................................................................GTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRPSGEAFVELESEDEVKLALKK--DRETMGHRYVEVFKSNNVEMDWVLKHTGPNSPDTA............................................................................................... 108
52 -15.900[K] KOG3152 TBP-binding protein, activator of basal transcription (contains rrm motif)  ali follow..  21  4.......................................................................................................................................................................................EESHELTDGISEEKESKETMKSQKADRKKKKLKEKLLKEASKADNRGVCYLSRIPPHMDHVRLRHILAQYGELGRIYLAPEASEGWVEFAKKSVAKRVADML-NGEQIGGKKKS....................................................................................................................... 143
53 -15.700[A] KOG4676 Splicing factor, arginine/serine-rich  ali follow..  17  29.................................................................................................................................................................................................................................GGGTEVIQVTNVSPSASSEQMRTLFGFLGKIDELRLFPSSRVCFVKFHDPDSAVVAQH--LTNTVFVDRALIVVPYAEGVIPDEAKA........................................................................................................ 121
54 -15.300[K] KOG4661 Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B)  ali follow..  12  361........................................................................................................................................................................................ACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNRCYGFVTMSTAEEATKCINHL-HKTELHGKMISVEKAKNEPVGKKTSDKR...................................................................................................... 495
55 -15.200[A] KOG4849 mRNA cleavage factor I subunit/CPSF subunit  ali follow..  10  48........................................................................................................................................................................................GGGGTPSADGAAGPGSGEPGERNSGGPNGVYHQSSGSLTPTMNRRYQLYVGNLTWWTTDQDIANSLRDIGDLQEVKFFQSKGFSVISLGSESSLRAVLDQL-PKKEMHGQAPVVTYPSKQALTQFESLQKTRPVPPPQQNGPPRGPAPPSMGGGPMPTGHPGGPQGGGPPGHPPRGMNSIMQPGQYRPQHMSQVPQVGGPNSGPPRMQPPMHPQGGLMGNQQPPPRYPS... 283
56 -15.000[R] KOG1995 Conserved Zn-finger protein  ali follow..  23  272.............................................................................................................................................................................................................................DCDDNCDNARIYISNLPPDVTTDELKDLFGGIGQVGNIKIYTDKGDACLAYEDPSAAHSAGG-FFNNYEMRGNKISVTMAEKSAPRAPTFDQSFIILVGNMSFCNAKF....................................................................................... 397
57 -14.800[AR] KOG0109 RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains  ali follow..  10  18MGRCAPNAERSAAPSAGPP--ADPCVGSDP-ASRAQALRGSPARLAARP------QPSAQKEVPESAVARLCPRGCLRGAVPFLPRPRGPELLAGSEISADPVICCPRGSGLATPRTLSGKWLTDEGRASSGCLNPNRCKPAPHAEGVGAGSRGGARAQRLLRIHGAFRTKRFSVRDKEDQWTVSVQRQLVYRPSTEAGHNNKEL-------------PPPLPPRGACPDDEAVHQKPAPGHRAGDPLSFQAVGKVLECDII--KNYGFVHIEDKTAAEDTIHNL-HHYKLHGVNINVEASKNKSKASTK.......................................................................................................... 380
58 -14.200[A] KOG0113 U1 small nuclear ribonucleoprotein (RRM superfamily)  ali follow..  19  102.....................................................................................................................................................................................................................................RTLFIARINYDTSESKLRREFEFYGPIKKIVLIHDKGYAFIEYEHERDMHAAYKHA-DGKKIDSKRVLVDVERARTVKGWLPRRLGG.................................................................................................... 193
59 -13.900[AR] KOG1365 RNA-binding protein Fusilli, contains RRM domain  ali follow..  10  181ARGLPWQASDHHVAQAGLDIVPGG-------IALCLSSEGRR----GEVLVQFS---------SQESRDLALKRHRNFLLSRYIEVYKAGLDEFMHVATGSSTEAMEFVSANAIIVRMRG--------------DCTDAQIRTFFEPLKLTDKILFITRTD--RPTGDAFVQFETEEDAQQGL-LKHRQVIGQRYIELFKSTAAEKRCNLINSSPAVANAVEAPEEKKKDCVRLRGLPYEATVQHIVTFLGDFATMQGVHMVYNSGEAFIQMINEQAASACAAGVHNNFMKKKRYIEVFQASAEELNLHHLVGQQH.................................................................................................... 482
60 -13.800[K] COG5175 Transcriptional repressor  ali follow..  12  16ALSNFDTSFLSEDEEDYCPLICQFCY----NIRQNPELNGR-CPACRRKYD----------------------------------------------------------------------------------------------------------------------------DENVRYVTLSPEELKMERAKLARKEKERKHREKERKENEYTNRKHLSGTRVIQKNLVYVVGINPPVPYEEVEKYFGQYGKINKIVVNRKTPHSYITFGSKDDAARCIAQV-DGTYMDGRLIKAAYGTTK................................................................................................................ 233
61 -13.500[A] KOG1996 mRNA splicing factor  ali follow..  16  306..................................................................................................................................................................................................................................CPTKVVLLRNMAGEVDEDETKEECEKYGKVGKCVIFEIPG--FLEFERVESAIKAVVDL-NGRYFGGRVVKACF.................................................................................................................... 390
62 -13.400[R] KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains  ali follow..  14  258TKFDKNTKQIRTFAFVEFSNRETA-LDDGRTLAVEYAKGDPACAHCS-------------NNFVKRQTCFKCEISKDQ--------------------------------------------------------------------------------------------------------------------------------------SMELEKLGAHMVGMTPCDTLLIRGLPDGINNSLIFDSLGALVCLSSISMIKSKRFAYLQMKSADEAKMLLNLTYKPIRIKDKDVQVSWCRDSMSKLIQQQMTML.................................................................................................... 453
63 -12.300[K] KOG2494 C3H1-type Zn-finger protein  ali follow..  10  1MTAVNVALIRTKWLTLE---VCRE------FQRGTCSRADADCKFCTRENCKYLHPPPHKTQLEINGRNNLIQQKTAAAMFAQQMQLMLQNAQMSSLGSFPMTPSIPANPPMAFNPYIPHPGMGLVPAELVPNTPVLIPGNPPLAMPGAVGPKLMRSDKLEVCREFQRGNCTRGNDCRYAHPTDAS-------------------------------------------------MIEASDNTVTICMDYIK-GRCSR------EKCKYFHPPAHLQARLK------------------------AAHHQMNHSAASAMALQPGTLQLIPKRSALEKPNGATPVFNPTVFHCQQALTNLQLPQPAFIPAGPILCMAPASNIVPMMHGATPTTVSAATTPATSVPFAAPTTGNQLK. 353
64 -12.200[R] KOG4307 RNA binding protein RBM12/SWAN  ali follow..  14  865..............................................................................................................................................................................................................................KSIGPRGTVLSCNGFPKDVTLEDVVEFFNDY-EPDSIRIRRGDGECMLACQNQENARRASMDL-DGQKLRNSVISVR..................................................................................................................... 946
65 -11.800[TZR] KOG1704 FOG: LIM domain  ali follow..  10  192......EAEGRSWHFHHF--QCAQCLADQKYMKCFHSSSSTSCTTCRLSFSS-HWHAS-----AECFCCCVCSKRVGESLFCGYQTCGGEDEELLDEDRLGSPHRKVTQKSTKVVRIPASPRVAPRHPHVIQQNLTTTMTIQKPSVVIQNQRPKPPQRAPPPPPSENIYETVLPCSSNNSPNFDKKYSHELPTSPNHHNYYSKTPN-NLLTGYPEMDGYSTSSSSDSDDEQLYISNIMAAASLSRVPAKSSSRKSKKNEPMMMSGG---VRMAKKKKSSRCTVS.................................................................................................................................... 489
66 -11.400[A] KOG4213 RNA-binding protein La  ali follow..  17  106................................................................................................................................................................................................................................NDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTKGSIFVVFDSIESAKKFVETPGQK................................................................................................................................ 174
67 -11.300[J] KOG0129 Predicted RNA-binding protein (RRM superfamily)  ali follow..  15  444..........................................................................................................................................................................................................................HQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAKGYAFLLFQDESSVQALIDACIE--EDGKLYLCVSSPTIKDKPVQ........................................................................................................... 540
68 -10.900[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  7  85.SEGIENQNRRMSNGNKVTLRDCLVLFGPAVANTK---DSIVF--------PVDTCMDIPASTSGFSSDEVEGSLRD----------------VRKIYASRVAAVDDEAHKRILFLEAKLRSIEQKTASWSNKEVQWKITEAELRLEVTKLKKKIANMESTTKGSQSQSNVASQEKYIPAHNIYQEHHGQSPSCSFRHQGDLLINGGRIFDIDGGRQILLYARRLSGVGGTFVLTQMSLHSPCEIDDILLPRTRAIKDLHLSPHNNGLAVFGSLGKKLSLESHNTVLSYDLPAAPWSCSWDLKSSH.............................................................................................................. 374
69 -10.600[K] KOG4218 Nuclear hormone receptor betaFTZ-F1  ali follow..  20  20.PIVSQFKMVNYSYDEDLEELCPVC-GD----KVSGYHYG-TCESC-KGF--FKRTVQNNKRYTENQNCQIDKTQRKRCPYCRFQLSVGMKLEA.................................................................................................................................................................................................................................................................................................................................. 109
70 -10.100[R] COG3582 Predicted nucleic acid binding protein containing the AN1-type Zn-finger  ali follow..  9  1MSAAIE-------KETGMLDVCAYCL---PF----------HCSFCNEDFC-------SNHRLKEDHHCRWLLEHEE-------------------VHKTEKSPSKSRDGSSSNDEAYFKSLLPERASVRIQRVSETREPLRGSNTAKVSSTLNSKTLDKIFKFFQRNEKRKSNNKSKKNFGSSSNKIIQLANLKKIAKGDPKIPMQNRIYIWYLVDGDETDIAKEDTRMPLYI---NKMWPVGRAMDYLSIQLNVKSSTLTNSSSNDKFQLCKLKEGKQVASLRVTNEIKDLDTLYLVHNNADEKSN............................................................................................................ 274
71 -10.100[J] KOG2314 Translation initiation factor 3, subunit b (eIF-3b)  ali follow..  11  7...................................................................................................................................................................................IDVLTAQLGINWSDVNLDSIQLPPGNDFGIESDDESVYQDDQSEFDTGFGNIIVVDHLPVEKLEGVVKKIYNQLGVIKENGLLMTLGYCFIEFNTPQEAQNAKEKSHGYKLDKSHIFAVN..................................................................................................................... 140
72 -9.840[R] KOG4198 RNA-binding Ran Zn-finger protein and related proteins  ali follow..  11  1MSK-LPSPTMPLPESVGDLVVLHNLIGRAP-LDGKTLEKQHCESCSIREDSSR------------HGICGSASSLTEA-PFTFVELRVLLPKEARDQGITLPS----------YMRHPRLFDLSSEYAKWQIRMGAVPPYTITLSHIFGKLDVDSLPPITESKAIELSPSDAPYITKGLTQCWRLANATTLLLRKAEKDSRGHSLP--SVLTQPINCQADARSFYAERSKIVHVAGLTNDVTQLELESWFTNHGALWTLK--KSTGTGFVLFASHEDAADALA--FNGYCLGDRMLEIIPSSTKVLDKASD......................................................................................................... 330
73 -9.600[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  15  312..VMMAAVKTYRWQCIE---CCNICGTSENDDQLL-------CDDCDRGYHMYCLTPSMSEPPEGSWSCHLCLDLLKE.................................................................................................................................................................................................................................................................................................................................................. 380
74 -9.430[K] COG5641 GATA Zn-finger-containing transcription factor  ali follow..  19  111.GQTMDANCNNNVSNDANVPVCKNC--TTPLWR--RDEHGA-CNACPRPISL------------KTDVIKSRNRKSNTNH................................................................................................................................................................................................................................................................................................................................................ 186
75 -9.290[A] KOG4008 rRNA processing protein RRP7  ali follow..  12  39..............................................................................................................................................................................................................................KKDPSKENSIIVSNIPAFVGEGVVLAIIDQFASFEVEESFVQRSTMSITFDKPEAVIQTLALCQD................................................................................................................................. 115
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;