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Query: [R] KOG0274 Cdc4 and related F-box and WD-40 proteins, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKSEPTSLDFTSSNLRRMNRDHSSNNTNRTVLNLPKEILIIIFSFLDPRSLLSAQCTCKYWKKLLSDDLSWRTAFFHHFAGDQSQIFSPLGNGTWRQEYLLRSTITRAYEKGKGQTVQYDCRVGQLTNLYYDFSSGRLYSGNWLTGTISVSDPTTGKVERSLLHASTDGSFTHGLSTMTLGKQIFGFGFMDGRVGVILMSRQAETPRKFRYCLDSHADSVTCIDALTGDLPPTGEIGMVTGSDDGSVHCWDVKTGVSLQSFQFRSSQILSLCFRPKYKMLLVDTFNYELNSYQLYLIPGYARSRKNEQPILLSSRKCVLTDEEEPPCLMTADCCAGVAFLSRGAPKNCICRVSFKEFLEKNDNVGVQTSSIPLNGKPTSISLDTNDRVLSKSTPGRGARLLAVGDENGLVYVVNTRTEDPNKAILRTITAYSNFPITDIYLNEVAMVVGSASGYCGVYDTVTGNFLKKIASARNAARREPINCILLDSNPLSLKGVITMSKHVKSWSYTIPKPFVNKRSKVLPLRPSVTHDNLSKSSDYSKNEVEREIMLGLDQIAQERREKMEARQKFEQHFGEGLVGLSEEEIIAYVTMLSQEEEAKRMVQLSMDVDKIEEDFKENDEQATSSLNALSSNHEPPQEQANVAELNEQEQIELAMRLSLMEMLast
1 -158.000[R] KOG0274 Cdc4 and related F-box and WD-40 proteins  ali  100  1MKSEPTSLDFTSSNLRRMNRDHSSNNTNRTVLNLPKEILIIIFSFLDPRSLLSAQCTCKYWKKLLSDDLSWRTAFFHHFAGDQSQIFSPLGNGTWRQEYLLRSTITRAYEKGKGQTVQYDCRVGQLTNLYYDFSSGRLYSGNWLTGTISVSDPTTGKVERSLLHASTDGSFTHGLSTMTLGKQIFGFGFMDGRVGVILMSRQAETPRKFRYCLDSHADSVTCIDALTGDLPPTGEIGMVTGSDDGSVHCWDVKTGVSLQSFQFRSSQILSLCFRPKYKMLLVDTFNYELNSYQLYLIPGYARSRKNEQPILLSSRKCVLTDEEEPPCLMTADCCAGVAFLSRGAPKNCICRVSFKEFLEKNDNVGVQTSSIPLNGKPTSISLDTNDRVLSKSTPGRGARLLAVGDENGLVYVVNTRTEDPNKAILRTITAYSNFPITDIYLNEVAMVVGSASGYCGVYDTVTGNFLKKIASARNAARREPINCILLDSNPLSLKGVITMSKHVKSWSYTIPKPFVNKRSKVLPLRPSVTHDNLSKSSDYSKNEVEREIMLGLDQIAQERREKMEARQKFEQHFGEGLVGLSEEEIIAYVTMLSQEEEAKRMVQLSMDVDKIEEDFKENDEQATSSLNALSSNHEPPQEQANVAELNEQEQIELAMRLSLMEM 662
2 -44.900[S] KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins  ali follow..  13  63.......SRMCHYQHGHINSYLKPMLQRDFITALPEQIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERM-NRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVL------TGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGE-----VLNTLIHHNEAVLHLRF--------SNGLMVTCSKDRSIAVWDMASATLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF------------------------------------------DNKRIVSGAYDGKIKVWDLQAAAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR................................................................................................................................................................................... 508
3 -31.500[R] KOG0646 WD40 repeat protein  ali follow..  10  2......................................................................................................................................EITVIASSSIDEGIGSWDLKTGTEQLQFKPCASPAHGLTAVGEKFLASSQLSARNTSGSIFYWSWTKPQ------AEVKSYPVEPIKALAA------NNEGTYLVGGGISGDIYLWEVATGKLLKKWHGHYRSVTCLVFSGDDSLLVSGSQDGSIRVWSLIRLFDDFQRQQGNTLYE-----HNFNEHTMSVTDIVIDYGGCNAVIISSSEDRTCKVWSLSRGKLLKN---------------------IFPSVINALALDPGGCVFYAGARDSKIYIGAINATSEYGTQVLGSVSEKGKAITCLAYDGNLLISGSEDGVVCVWDPKSLRHVRTLIHAKG-----SRKGPVNNIQIVRKTIVANSNKTQVSWKSRGALIPPPLEKYERPVEDTMDGIVTVDPPPFSDVPVYSSIDEQVKELQQQGSAATEMEMERLKLEYKRSLQMNEQQVVMEEEQIGGTN.................................................................. 438
4 -29.900[D] KOG0642 Cell-cycle nuclear protein, contains WD-40 repeats  ali follow..  461.........................................................................................................................................................................SHFDGIRALAFIEPVLITASEDHTLKMWNLQKTAPAKKEPIYTFRAHKGPVLCVVM------SSNGEQCYSGGTDGLIQGWNTTNPNLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTT---------------------------------ANSSCQINRVISHPTLSISITAHEDRHIKFYDNNTGK-----LIHSMVAHLEAVTSLAVNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFE-ESIHDVAFHPSK---CYIASAGALAKVF............................................................................................................................................................ 779
5 -29.200[A] KOG0291 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  10  303.....................................................................................................................RKEQRDVQLTAANYNTRTKVLVVAFSS-GAFYLYELPDVNMIHSL------SISDYPISAALFNCTVALASREIGQLLVWEWQSEQ-----YIMKQQGHSSEMTCIAY------SSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFDVNRYRNFRTFAQFSCVAVDYSGELVVAGGQDVFDIFLWSVKTGKLLEIISGHEGPVVSIAFTSSTLVSGSWDKTVKIWNCLESNSEHETIDAVSDVTNVTFSPSGEEIAVATLSGNITIFDIKSAGQVTDIITARKNAQANYFSTIEYDGECILAAGKSANICIYHVREAILLKKFEITQNFQQEVRVFSVKFSPTGQAFAAAGTEGMSLKLNEPNLIALVLERVPYKDVELVCADLSPEFAQRTKHGNQDGVFQHTGLLALHEVLSRKYEMLNKICDYN---------KYTLKVLLDRADKLEQKNEGKPNATEEDSDEEML-------LIRSKDDENGQAQFSDEEESDSGSEEEMA.......... 949
6 -28.400[R] KOG2444 WD40 repeat protein  ali follow..  11  12...............................................................................................................................................................................MKSNKDGSRLVVGFVDGSIRFYDTQQHEEEFQ--EIWKFQTKSSIRGVDL------DEHKKRVYAVTKNRSLCVFDIDTGKRVRCIKCHRSVPTAICTALKSQQLATADESGEVKTWNLDPEVASEQEQDEDINDLKVDVKSNLLATSSDGTLGAYDLRKAKLKMRSELMHSELYSVCG------------------------------------------TNRSVYVGGEDGYVEVFNLNEYGNLLE---RVESGFEMGVNGIVESGLLGLTSQGSNRMRLLNVQPSKRLGYAGYHGDKSDDDGIDAITISTDKSTVFTMISMSCTIKKWDMGPIIDEIPILRAQDAKSKKMRKTEDGLVGPKNDSDSDDDDEPKSKKRRNDEDSDEEIDEEEQEEDDEEEEEDSD................................................................................ 383
7 -27.900[T] KOG4378 Nuclear protein COP1  ali follow..  11  1.............................................................................................................................MMSNLVEPSWRLLAASG--GDTVKLFDVSADSGDPCVLSYTPSPGCAVNSVKWNHTNLVVASTGEDKKISLWRKNGQSTVPVTGKDGGDSAEECLSAISFSKK-----GSRYICSGGTGQIVKIWDLQRKLCIKKLKGHTSTITGVMYNCKDEHLASVSVGGDLIVHNLASGARATELKDPNGQVV-----------------------------------------------------------------------QFVHVLRLLDYSRSSRHLLVTAGDDGTVHLWDTTGRS----PKMSWLKQHSAPTAGVCFNEKIIASVGMDKKLYTYDSGSRRSSSCIAYEAP------FSSLAFGDNGY----ILVAGTRVVFYDIRGKPQPVTVLHAFSN-------------------------SEDVTSLSWQTSKPVIVNEKNYTSEMALLGSTVEDSVVIPDPLPSTTPSASQSAMAPGSRGVSASTVNASSVEQTPNRNHLWPSGPLGRLHALRANDSYNDDMGVFSPII.... 424
8 -27.300[S] KOG0294 WD40 repeat-containing protein  ali follow..  12  45.........................................................................................................................................................................SYARSITSLAVQWPWVASGGTDGRIFVYDMRTRKQSQ-----IILSHAGRVNTLKFTP------DLSLLLSGSDDGHMIATRVGSWTKEYDWQKAGQAVTHVSCHPSSKLALSLGGDQVLNTWNLVNGCVAHKTNLKN-----------KATLDFQTGCLSWSKQGDHFTLSGPLVLEI-------------------------GIENAHVMRRIEMPSKPICITWLDGNECLTGLDNGNIAWISLKDEDDT---PPTFILAHEVRVKAIAYLNEFLATVSIAGQIKVWKIDMETRKLEEIARSF------------------------MDCRPTDLGLLDLRQFGNVRPVEQRTKVEEKPKAKVESDQSAKPAAPRGFVTIEYEQDKKLDAEKKKEKKKNKK--------------------DEESSEESNSSEDKENDDFSDSDSDVSSDHGHRKRKPMKREQQPTPASKGKAKQQKKK............ 434
9 -27.200[S] KOG0271 Notchless-like WD40 repeat-containing protein  ali follow..  11  98...................................................................................................................SASIPGHGEPVISAQFSPDGRGLASGSGD-QTMRIWDIELELPLHTC------KSHKSWVLCIAWDATKIASACKNGEICIWNAKTGE----QIGKTLKRHKQWITSLAWQPMHKDPTCR-LLASCGKDGNIFIWDTVQGTVVRCLSGHTASVTCLRWGGEGL-IYSGSQDRTVKMWRADDGVMCRNMTGHAHTLALNTDYALRTSCFEPSKRCIKPDTVEECQKVAQTRYEAALEIAGGERLVSGSDDFTLFMWNPKETKQSINRMTGHMQLVNQVVFSPDTRYIASASFDKSVKLWCGRTGK-----YLASLRGHVGPVYQVAWDSRLLVSGSADSTLKVFELKTKSLYYDL-----PGHGDEVFTVDWSPE----TKVVSGGKVLKLWR........................................................................................................................................................... 472
10 -27.100[S] KOG0310 Conserved WD40 repeat-containing protein  ali follow..  10..........................................................................................................KFLSRKQETILLDEDEPAVVSSVRISPKKPYHVATTSS-VRLTLYDTVVCEPLNLF------SRFKKGVCSIDFDGRLLAIGGDEGKVRIFDVEKTTGSSKVALRVMQASQSTVKSVHF------SPRGDTVFSMADDGKIKQYRVADTAYIIEIQAHEDAIRCGAVSSNDHIVLTGGYDHKVRLW---------------------------------------DIRSKEKSLELDCEHPVESVLFLPGEQLIATAAGPIVKIWDTTTGRQLTALQAHYKTVTSLRLATNSTCLLSAGIDRRVNAFRTTNYSLINS-------SMPSPVLDIDVDDQTMAIGMGNLLALYRRAEIKKEATASAAIEDKRSLIRTSKVDVVAKNADKLKIPKIDGMLSNFKHAAVIKLLFGGKFRSAMDTVMRGAIHRALAGQERSVQDKDVVKHVQSLRGSLGRELEVQKMISSLIG----------SIDLIVSTTKMNVKSSSTALIEDNDVFGE--------PTIRARDLDELKPSDQGAEEEYEENMQIN............ 547
11 -27.100[S] KOG0282 mRNA splicing factor  ali follow..  253...............................................................................................................................................................................SYLHIPQDVGVNLRSTMPPEKCYLPKK------QIHVWSGHTKGVSAVRLFPL-----SGHLLLSCSMDCKIKLWEVGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLR-DIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFDMSYVISGDGNGKLNIWDWKTTKLYSRF-----KAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD........................................................................................................................................................... 579
12 -26.900[I] KOG0301 Phospholipase A2-activating protein (contains WD40 repeats)  ali follow..  1.........................................................................................................................................MADDGLGDVPMETESMPQYTISHVI------EAHKSDTKALAVQGGCLISGGRDETVKFWAKKGKQYT--KTHAFEQPKGITVNSIAY----AELADGWRLFVGRRDGTIAVFGPSQAEPYAIFNEHKQNVCCLHINEKATHMLSGSWDSNVIIWPITELN-----------------------------------SSSFTTIVCPGHTLSVW---------------------------------------ALASFPDLPNTYLSASADKTIRMWFGDT-------TLSVFKGHTDVVRALVVSSSHFLSAGNDGHIIHWDVASASILRKFATQ---------AHEFIYSMTLSDSHILTTGETLEFWAIDGGKDGNLAIVSEAVIQLPTTNSDIAVAGSDGRIYIDDILDAFDAEVVAKLTAKTERMKQEEHETVTIKVDIDDRPTQLNLKYKKGTDPGLCAQEFLSENNLPIHYLEEITRFIKDRIPEARAFDLKSGKKVIVDGKEYD----YALGVNFGK. 441
13 -26.800[R] KOG1539 WD repeat protein  ali follow..  216...........................................................................................................NIKLDEEIVTFEHASRGAVTALSFSTDGRPLLASGGSFGVISIWNLNKKRLQSVIRDAHDSSIIS---LNFLANEPVLMSASADNSLKMWIFDTNDGDPR-LLRFRSGHSAPPLCIRFYS------NGRHILSAGQDRAFRLFSVIQEQQSRELSQRHISRRAKKLRLKEEELKLKPVVSFDCAEIRERFVSRNHLLLAILACAISACGNFAVVGTAGGWIERFNLQSGISRGSYFDMSEKRRYAHDGEVIGVACDSTNTLMISAGYHGDELKSQWDVGCSLVKIVYHRVNGLLATVADDFVIRLYDVVTLK-----MVREFRGHTDRITDLCFDGKWVISSSMDGSLRIWDVILAKQIDGVHVDVP------ITALSLSPNMDVLATAHSDQNGVYLWVLPSVSALTSSEADDDMDRQVLENSEALQASSFSISQKQIPELVTLSLLPKSQWQSLINLDIIKARN-KPIEPPKKPEKAPFFLPSIPSLSGDILFKANDSEADGENEENNKKDQNSMKNFDALESPFSKHLKSSWDSKHFLDFTNYMKSLSPSAL 826
14 -26.700[S] KOG0316 Conserved WD40 repeat-containing protein  ali follow..  24...............................................................................................................................................................................ARFNGDGNYALTCGKDRTIRLWNPHRGI-----LIKTYKSHGREVRDVHV------TSDNAKFCSCGGDRQVYYWDVSTGRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWDCRSHSVEPVQIIDTTVMSVVLTKTEIIGGSVDGTVRTFDMRIGREMSDNLGQPVNCISISNDGNCVLAGCLDSTLRLLDRTTGELLQVYKGHISKKTDCCLTNSDAHVIGGSEDGLVFFWDLVDAK-----VLSKFRAHDL-VNSIDVDFLKFFVAGDKRELPPEGRLYVDFFGRWYNSCLEKMKKQQ------LTSIDFVIYVSNSPFFFYYRL.......................................................................................................................................................... 343
15 -26.700[S] KOG2106 Uncharacterized conserved protein, contains HELP and WD40 domains  ali follow..  10  176.......................................VKCLAVHPDRITIATGQVAGTSKDGKQLPRIWDSV-----------------------------------TLNTLHVIGIGFFDRAVTCIAFSKSNGLCAVDDSNDHVLSVWDWQKEEK----LADVKCSNEAVFAADFHPTDTNIIVTCGEITSLLLDTRRKLPLIRSKDYSRTRKAKVVLCVTFSENGD-------TITGDSSGNILVWGKGTNRISAVQGAHEGGISPLCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKPQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKD-----LVTVHTDGNEQLSVMRYDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKC-SGHSSFITHLDWSVNSQFLV-SNSGDYEILYWVPSACKQVVSVETTRDPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGGHSSVTNVDFLCED--SHLISTGGKDTS................................................................ 710
16 -26.600[R] KOG2321 WD40 repeat protein  ali follow..  10  16...............................................................................................................................................................................VSGEGVTQRLPNWISKRKLKKDYALSHRIE----LLQDFEYPEASNRIKCTRD-----GKYAMATGVYKPHIKVFDFAEMSLKFERHTDAENVQFEILSDDWTKSVHLQTDRTVDFHSQGGIHYSTRIPKYGRDLKYHYPNCDLYLAAAGDEVYRLNLEQGRFLNPLKIESAQI---------------------------------DSPTGGVNVIDINPMHQLLAFGTDAGSVEFWDPRDRSRPSTVPSTPYSDNSRSVTALKYDGLNVAIGLSDGATLLYDLRSSSPYMSKDQ----GYSMPIKSLHWMDSALDGTARVLSADIIKIWEKDTGKPFSSEEHRQKIVKERLEKQRASKIRSQNRPKVNAGLASRLSYQENKLRKKTGVTDGPSILEDERFKNV-DEDTLEYKQLHPSRSEARGLTAAEESEEEKEHTKGIKFSSDEESLSDMEEENETFDALVDRRKTEQQVSNEKTPQETIRS. 585
17 -26.500[A] KOG0319 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  10  118........................NEEGHLLATGSADHIVKVWN-LKGPSVVSAILFGKHEKLVVGYINLYNKLVNTWKSHNSHITALLQVPDSRVVVALSRDQTMSIHETETQETLRVLPLYESIEGGAIGHNGNLFTVGE--EGVVKEFVIETAKL----VRKKRIASSNLDHLAYDVVSNRFLAISAEQNLIILDFENLK----IARQIVGFHDEIYSCCLL------GKDESHMAVASNTSEIRLYNTKTLDCQLIRGHTESVLSVVSPTWDTSLLASCSKDNSIIFWRLVTSPENDSCSTLVPVAAATGHANTVTA-----LAISNTGRAPFLASVSTDCTIKLWGLGVSTKLKEVKIDAEKDFVEQLPKLTCSSTMVAHGKDVNCVDISESDALIATGGMDKLVKLWQVDTHKMQLG-IAGTLSGHRRGVGDVKFNSHKLASCSGDMTIKIWNISEKSCLQTISGHSCDAHTDKIWSLSKNHNESE---FVTAGGRIVVWKDVTEEKQKAEDNKRREAIEQDQTLTNLLSQKRYSEALVFALTLA-KPFCAFKVINALMAEETPEELGSAIRRLDTRQIEILLQFTVKWNTNSRTSSVAQRVLYEIVHIVDPEELVSMPGAYGYIESFLPYTQRHMDRLDRAKQDVSLFDFVWRQM 789
18 -26.500[A] KOG1272 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  42..............................................................................................................................................................................VKKYLRGEGANLETLKDKKLKTQLASREKL-----YGKSAKAAAKIEKWLL------PAEAGYLETEGLEKTWRVKDILSSRNQYDIVLPDFGPYKLDFTASGRHMLAGGRKGHLALLDNMSLIKEIQVRETVRDVAFLHNDQFFAAAQKKYAYIYGRDGTELHCLKERGPVARLRFLK-NHFLLASVNMSGQLHYQDVTHGGMVASIRTGKGRTDVMEVNPYNSVVGLGHSGGTVTMWKPTSQAPLVQ-----MQCHPGPVSSVAFNGHLMATSGKERKIKIWDLRKFEEVQTIHSF-------HAKTLSFSQK----LLAAGTGSFVQILGDSSGGSSHNYTRYMNHSMGIGHSMGWSSILIPGSGEPNFDSWVA-NPFETSKQRREKEVHSLLDKLPPETIMLDPSKIGAMRPSRRKEKPSRGEIEAEKEVAIEAAKSTELKNKTKGRNKPSKRTKKKKEMVENAKRTFPEQEHNTAIKKRRIV. 530
19 -26.500[S] KOG0296 Angio-associated migratory cell protein (contains WD40 repeats)  ali follow..  14  53..................................................................................................................SVQGFFEHKDSVFSVSINPVHSNLCASGGGDDLGYIWDITTGEQICQL------TGHKDSIVAIDWDGTYIATGGMDSQVRLWKSSTGFE-----FITAFETVDEIVWLSW------HPKGLFLAAGCNDGSIWMWSLPSGKVVQVMYGHTAPVNAGKFPGVGKRLATVDDSGTLIVWNPATGAPECRMSSDDHRFDPGNEET-----AAGWTSFDCNAEGNVLFLGGSSGKVKV---------------------VNINSSHILASLEAQTESVEAIALCTALPICACASVDGTVALYDSASLK------FRKSLPHEQAVIDCKFNTPYLLTACADCVIRKWDVRSGQLLGEY-----TGHQEPILCMAITPD----KRVVTGSDELLVFDCEH........................................................................................................................................................ 399
20 -26.400[K] KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA)  ali follow..  11  330...............................................................................................................................................................................AEFSPDSTMIACGFQESYIRLWSIKADKKSDSDGSVRLLSHSGPVYGTTF------SPDNKYLLSCSEDASARLWSVDTKTALVAYKGHTGPVWDVAFGPFGHYFATASHDQTAQLWSCDHIYPLRVFAGHLSDVTFHPNSAYVLTGSSDKTCRLWDVHRGHSVRVFNGHTQPVTAVAI----------------------------------------APDGHTMASADSEGLIHLWDIGTGR-----RIKTMRGHRGNIYSLSFESTVLVSGGSDCTVRAWDVFKTNYNNPVSSSLTSAKTSTFNEVNWSTSPDQMVALYTKQTPIFNVSFTRRNL..................................................................................................................................................... 636
21 -26.300[A] KOG0285 Pleiotropic regulator 1  ali follow..  104............................................................................................................GPTLPPRDLNNTGNPGKSTAILPAPGSFSLSTAALMERMPSRWPRPEWHAPWKNYRVLQGHLGWVRSVAFDPSNEWFCTGSADRTIKIWDVATGV-----LKLTLTGHIGQVRGLAV------SNRHTYMFSAGDDKQVKCWDLEQNKVIRSYHGHLHGVYCLALHPTLDVVLTGGRDSVCRVWDIRTKMQIFVLPHDSDSVLARPTDPQVITGSHDSTIKFWDLRYGKSMATITNHKKTVRAMALHKENDFVSASADNIKKFSLPKGEFCHNMLSLQRDIINAVAVNEDGVMVTGGDKGGLWFWDWKSGHRAETIVQPGSLESEAGIYAACYTGSRLVTCEGDKTIKMWKEDEDATPETHPLNFK............................................................................................................................................................................................ 469
22 -26.200[R] KOG0286 G-protein beta subunit  ali follow..  14..........................................................................................................................................................................LKKQIADARKACADVTLAELVSGLEVVGRVQMR-----TRRTLRGHLAKIYAMHW------ATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFS----ESIICGITSVAFSGRLLFAGYDDFNCNVWDSMKSERVGILS-----GHDNRVSCLGVTADGMAV-ATGSWDSFLKIWN........................................................................................................................................................... 340
23 -26.100[A] KOG0265 U5 snRNP-specific protein-like factor and related proteins  ali follow..  5.............................................................................................................RPNNSVILAQEAKRSKNDLMAYTNRDKALLESGVRRTSNLQAPIMQLEGHEGEIFT----------AEFHPEGELLLSSGFDRQIYIWQVYEDCENVMAM----SGHSGAVMEAHF------TPDGSHIFTCSTDKTLAFWDIATGQRQRRFKGHGNFVNSVQGSRRQQLLCSGSDDRTIKIWDARKKHAAHTLESPFQAVCFGDTGEQVISGGIDNEVKIWDIRKQAVLHHLRGHSDTITGMSL----------------------------------------SPEGDFILTNAMDNTLRVWDVRPYAPGERCVKVFQHNFEKNLLRCAWGSDKITSGSADRHVYIWDVNTRRILYKL-----PGHNGSVNAVDFSPKEPLI-LSGSSDKTLYLGEIDE........................................................................................................................................................ 347
24 -26.100[S] KOG3881 Uncharacterized conserved protein  ali follow..  11  16.......................................................................................................................................................................................RALTFDSLGLIKVTEARGQERGIPTVVNTEMNASRSVLAASIDDR----LRNPLLAVARKDGNVEVINPCNGDLHFSYSLHLFRKKIDDQTERSCTLLTCTKKGDVSLRSVKFPDAHGNSTDDASPGKVDGSENFSLFGGKRVEANIWDLEQCTKIWSAKC-----------------------------PPKNNLGIFTPTWFTSATFLSKDDHRKFVTGTKSHQVRLYDISTQRR----PVLSFDFRETAITSIAEDGHTIYVGNASADLASFDIRTGKLLGSFLGKCSG----SIRSVVRHPQH---QVIASCGRYLRVYDVKTRQLISAVFLKQHDSGFSGEETAVANTVAEAATEEKMTIMDQEDDETEKAPVKRKKSKKEKRSREIVFEGEDDEEN-------EDEIEKAPVKTKKSKKEKRSREKVSEGEEKDELRSKKTREHKKKTKIVKHNQED................ 468
25 -26.100[S] KOG0308 Conserved WD40 repeat-containing protein  ali follow..  32.......................................VSALQY-QNGRLFTGG----------SDTIIWSVPHHKDAFSARGGVRSPGKNSPVQ------------------YQGSLEQHTDWVNDMILCGHGKILISASND-TTVKVWNIERDNKHGFIDCIRTHKDYVSCL-AYAPIVEKAVSASFDHNIFVYDINANFKTVNNL----IGCKDSIYSLAT------TPNLSLVLGAGTEKCIRLFDPRTNEKIMKLRGHTDNVRALVVNDDGTRALSAGSDATIRLWDIGQQRCIATCIAHEETLQVDSSFTTVYSAGKDKMVVKTPLYDFTKSQLLFKEEAPVKKLLLSEKDNPVGTWKSDIKRWSIRPSAQLSIGGDEDGPSTSNANHSVSASSSPPVTFKYIRVKDQKGQQST----PELVIPGAPAIKKHAMDKRHVLTRDSDGNVALYDVLAARKIKDYGKRIFEEVVDENSRQVYIPS---FVVDSKSGMQITLDELDALSSWLSSKDAGFDDNDRETKQIIVNYGGMMLRSLFERWPPCKMTNVDAADADDVQKATLNFISGKEFEANELAQIAPMKMPFYLLPHPSTNPKQPKKDRLSATEMLQVKKVMEHVYEKILSTNDVGSIPLNQIHTKNDQRLEPDMDLRTVEL 675
26 -26.000[A] KOG0268 Sof1-like rRNA processing protein (contains WD40 repeats)  ali follow..  10  46...............................................................................................................................................................................................NATKLERVFAKP-----FLASLDGHRDGVNCLAKHPE-----KLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTYTGIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDT----PVMVHMDHVSAVLDVDYTGKEFVSASFDKSIRIFPVDKSRSREVYHT----KRMQHVICVKWTSDS---KYIMCGSDNIRLWKANASEKLGVLTSREKAAKDYNQKLKEKFQHYPHIKRIARH-QIQEQRIMKEARRRKEVNRIKHSKPGSVPLVSEKKKHV............................................................................ 440
27 -25.700[A] KOG0299 U3 snoRNP-associated protein (contains WD40 repeats)  ali follow..  10  57.......................................................................................DEENEDTYETAAEKRLRLAREYLDEVKNELVEDGGFDAKEVDRELLASRLKEDVLEKKGQMYLDYTSKINPDVKIETAQLRGRHMRPLVGVVAYENFVYSADKSGLIQKWEALQEKDKFSRSRRGENDHVKEITCLAI------SNDGRWIVTGGLDHRIVIRDSVTLEPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWSLDQMSYIETLFGHQDVIFGLARERCVSVGGRDRTSRLWKIVEESQLVFRSG-------------------------------GTSMKATAGYMEGSVDCVAMIDEDHFVTGSDNGVIALWSVQRKKAETSPDPVTIPPQPRWITSLAAYSNLFASGSWDGNIRLWKIAEGRSFEPLTIATPLSVYGCINSLSLSLQQSEVRVFAACGRRVGRWKTLRGIPN.................................................................................................................................................... 501
28 -25.600[R] KOG1273 WD40 repeat protein  ali follow..  10  2................................................................................................................................................................................................NAPIIDPLQGDFPE---VIEEYLEHGVIKCVAF------NHRGSLLAAGCADGGCVIWDFETRGIAKEIRDNSAAITSVSWSKYGHRLLVSAADKSLTLWDVSTGEKIARTILQQTPLQAR---------------LNPGLSSPSLCLACPLSSAPMIVDFDIDCTTLLPVSVPEMPDVLAPPQRSKCPESNPPFSPAAACFNKCGDLVYIGNSKGEILIVDYKSVR----VLALVSASGAAPVKNIVFNGQYLLTNSHDRTIRIYENLLPACLTLFREFQDSVTKMHWKAPCFSGDGEWVVGGSACKGKIYIWDRAGHLVKILEGPKEALIDLAWHPVHPIIVSVSLAGLVYKELEENEEYVEREDEPETEKVKVLDVNEDEEVDIDTVEKDAFSDSDMSVEELRYLPAEPIPDTNDQQDNLVESIKLIEGQISASPASEEAGQNGHHASSPQAGKKDSNS........ 472
29 -25.500[B] KOG0273 Beta-transducin family (WD-40 repeat) protein  ali follow..  11  171..................................................................................................................KATVLRGHESEVFICAWNPVSDLLASGSGD-STARIWNLNENSNGGSTREGGHDVPSNKDVTSLDWDGTLLAMGSYDGFARIWTENGN------LASTLGQHKGPIFALKW------NKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMT-FASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNADPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIK--------------------------------SPTGPATSNPNSSIMLASASFDSTVRLWDVEQGV-----CTHTLMKHQEPVYSVAFDGKYLASGSFDKYVHIWNTQSGSLVHSYQGT------GGIFEVCWNARGDKV-GASASDGSVCVLDL.......................................................................................................................................................... 522
30 -25.500[U] KOG0276 Vesicle coat complex COPI, beta` subunit  ali follow..  13.........................................................................................................................................................................QRSERVKSVDLTEPWILASLYSGTLCIWNYQTQV-----MAKSFEVTELPVRSAKFVA------RKQWVVAGADDMYIRVYNYNTMDKVKVFEAHSDYIRCVAVHPTLPYVLSSSDDMLIKLWDWEKQIFEGHSHYVMQVTFNPKDTNTFASASLDRTIKIWNLGSPDPNFTLDAHQKGVNCVDYF--------------------------------------TGGDKPYLITGSDDHTAKVWDYQTKS-----CVQTLEGHTHNVSAVCFELPIIITGSEDGTVRIWHATTYRLENTLNYGLER-----VWAIGYIKSSR----RVVIGYTIMVKLGREIPVASMDNTGK-AKHNEIQTANIKSIGADYEVTDGERLPLSVKELGTCDLYPQSLK------NGRFVVVCGDGEYIIYTALAWRNRSFGSGLEFVWSSEGECAVRESSSKIKIFSKNFQEKRSIRPTFSAEKIFGGT............... 438
31 -25.400[S] KOG0293 WD40 repeat-containing protein  ali follow..  10  33..SSVNSNSLGDLMARPLPSQGDDETIGSKGVIRKSEFVRIITRALYSLGYDKTGAIKLFLQQVKDGK--WDQSTLHRIGFPDEKAVKAASFLLLEQKFLKVEKIADALRTLRNEMAPLRINTKRVHELASSLISPSSFISHTTSTPGKESVNSRSKVLEKRLECLVENSLHIQRDSCVFTLDSDLSLYSDHQCGKHQIPSQ------TAQILESHTDEVWFLQF------SHNGKYLASSSKDQTAIIWEISADSLKHTLVGHHKPVIAILWSPDDRQVLTCGAEEVIRRWDVDSGDCVHMYEKGGISPISYPDGQGIIAGMTDRSICMWDLDGREKECWKGQRTQKVSDIAMTDDGKWLVSVCKDSVISLFDREATVERLIEEEDMITSFSLSNDNKYILVNLLNQEIRLWNIEGDPKIVSRYK---KRSRFIIRSCFGKQAFIASGSEDSQVYIWHRSTGKLIVEL-----PGHAGAVNCVSWSPTNLHMLASASDDGTIRIWGLDRINQQNQKKKLVQG........................................................................................................................................... 576
32 -25.400[A] KOG0306 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  10  376....................................................................................................................................................................................GELKAVFLLQNNLVELYSLNPSLPTVRTSRITIGGHRSDVRTLSFSSDNIAVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTR-----TLQLDEDVLCVSYSPNQKLLAVSLLDCTVKI----------------------YVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGD-----CHKSLFAHDDSVMYLQFKSHLFFTAGKDHKIKQWDADKFEHIQTL-----EGHHQEIWCLAVSPS----DYVVSSSHSLRLWE---------------------RTREPLILEEEREMEREAEYEESVAK-EDQPAVPGETQGDSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHKAICKAA--KEVPLPSNPILMAYGSISPSAYVLEIFKGIKSSELEESL-LVLPFS.... 830
33 -25.400[T] KOG0279 G protein beta subunit-like protein  ali follow..  12  1.............................................................................................................................................................MAEGLVLKGTMCAHTDMVTAIATPSDVIVTSSRDKSIILWKLTKEDKSYGVAQRRMTGHSHFVQDVVL------SSDGQFALSGSWDGELRLWDLATGESTRRFVGHTKDVLSVAFSTDNRQIVSASRDRTIKLWNTLG-------------------------------------ECKYTISEADGHKEWVSCVRFS--------------------------------------PNTLVPTIVSASWDKTVKVWNLQNCK-----LRNTLAGHSGYLNTVAVDGSLCASGGKDGVILLWDLAEGKKLYSLEAG------SIIHSLCFSPNRY--WLCAATENSIRIWDLESKSVVEDLKVDLKAEAEKTDGSTGIGNKTKVIY---TSLNWSAD--------------------GNTLFSGYTDGVIRV.......................................................................... 320
34 -24.800[S] KOG1407 WD40 repeat protein  ali follow..  13  26...............................................................................................................................................................................VAWNSNGTKLASGSVDQTARIWNIEPHGHSKAK-DLELKGHTDSVDQLCWDPK-----HSDLVATASGDKSVRLWDARSGKCTQQVE-LSGENINITYKPDGTHVAVGNRDDELTILDVRKFKPLHRRNYEVNEIAWNMPGDFFFLTTGLGTVEVLSYPSLKPLDTLTAHTAGCYCIAI----------------------------------------DPKGRYFAVGSADSLVSLWDISD------LCLRTFTKLEWPVRTISFSGEYIASASEDLFIDIANVQTGRTVHQIPCR------AAMNSVEWNPKY---NLLAYAGDVFRIFGFESS....................................................................................................................................................... 315
35 -24.800[S] KOG0295 WD40 repeat-containing protein  ali follow..  12  9...................................EEINRAIAEYMQNNGYSESFSVFLKESSLSENDIILE-------------------------------------KKWTTVLRLQRKVNDLESKLQESQREINHGAPTRD-KRQAADWIPRPPETQKL------TGHRLPITRVIFLWTIMASCSEDATIKVWDYETGQ-----LERTLKGHTDAVNDIAI------DAAGKQLVSCSSDLSIKLWDFQTYDCLKSLKGHEHTVSSVTFLPTGDFVLSASRDHTIKQWDISTGYCVYTFRGHNDMIRISNDGTLFASASLDQTVTVWSFATKSAKLVLRDHEHAVECVEWAPDTAYTNVTGQQPE-------------------------GNSTHILFSGSRDRSIKAWNINTGD-----VLFTLLAHENWVRGLAFKGKYLISVADDKTLRVWELSAQRCMKAI-----EAHEHFVSTVAFHQTS-PFVITGSVDMSCKVWEC.......................................................................................................................................................... 403
36 -24.400[S] KOG0772 Uncharacterized conserved protein, contains WD40 repeat  ali follow..  1.............................................MDDNTAPKKNSKARVFDQAMFAQTISNAPRTEEPTHVPQSVSVSSKSESGVSSSAVSDDEDDFMPDLPPGFQMQQSEAGPSSSRAEGPEDSDDSDFD-ETEAISIIKLIPAACEAKI------SHGTQAISALRVPGVRFASGGLDYYVKLFDFQKMDMSMRYDKELLPAESHVINSLAF------SPNGETLVVASGEAIIRLLDRAGKQWLNITKGHTATVNCVEFNLNKNEFISCSDDGSLRLWNLDDHKVITKCINKHRKVIKTKG---ANGKRVSPQVCTFSPDGKWIAAGCDDGSVQA-------------------KYGSQYVNVNYLVRKAHNGSITSIAFSPDSKRLLSRGFDDTLKMWSLDNPKEPL--LVKTGLENAFKSTDCGFRAEVVFTGTSPGTLQFFDPMTFDLVYKIDYPGI-----SCHRIQWHPRLNQIIAGLSDGT-IHVYYDQTMSQRGVMSCVTKPLKRNRASGEEGEEKEVTGWRIKKYLRMQDNKLRPEFRKPADMPINGKSANGRVAASGGSLHSYLAKQIGTARNAEFLKDTDVRASILKHAKDAEENPLYIDKAYRKTQPKKIFQETAVEPEDQDDEELQPVFKMPRTK. 620
37 -24.400[Z] KOG0313 Microtubule binding protein YTM1 (contains WD40 repeats)  ali follow..  11  104..............................................................................................................................................................................ISSIKGAEEWILTGSYDKTSRIWSLEGKS------IMTIVGHTDVVKDVAWVKK---DSLSCLLLSASMDQTILLWEWNVEKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQ-------------LGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVGSGSLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSL--VSLSLTSHTGWVTSVKWHEQQLISGSLDNIVKLWDTRSCKALYDLAAHEDK-----VLSVDWTDTGL----LLSGGNKLYSYRYSPTTSHVGA................................................................................................................................................. 423
38 -24.300[Z] KOG0318 WD40 repeat stress protein/actin interacting protein  ali follow..  7..........................................................................................................PAYENKNIYATLPRTQRGQPIVLGADPKGKNFLYTN--GNSVIIRNIENPAIADVY----TEHSCAVNVAKYSPSGFYIASGDASGKIRIWDTVNKESETGTSVGEISGQSKSINSADFRPA-----RPFRIVTGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVRYSPDGKFFASAGFDGKVFLYDGTSSELVGEFKGGVYALAWKPDSTQLLTCSGDKTCRLWTVESRELVSETTVDDQQVSCLWQGDNLITVSLSGVITYLNVADPSKPLRVVKGHNKPITVLGLSDDRSTIYTGSHDGVVTNWNSGSGTNDRIT-----TGHGNQINGIAAWGDFVYTCGIDDSLRQFSVEGNSYTDYVVKLNCQ-----PRGLAILRNEN--IIALACIKELTLVQDQKKIFSLPIKYEASSIAVNADTSDVAVGGDDQKLHI--TLKGGVLEPKVELDHLGAVTDVSYSPDLKYLVACDAHRKVVLTVAWSPNSLLVASGSLDTTIIIWSVANPAKHTIIKNAHPQSQITRLVWLDNNTVISTGQDCNTKV----HVENI 608
39 -24.200[JT] KOG0643 Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1)  ali follow..  13  5...................................................................................................................................................................................................................LLQGHERSITQIKY------NREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLK-----------------TNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSF-----------DLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGE-----VLVNVKEHSRQINDIQLDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPKGHFGPINSVAFHPD----KSYSSGGEYVRIHYFDPQY...................................................................................................................................................... 318
40 -24.100[R] KOG0322 G-protein beta subunit-like protein GNB1L, contains WD repeats  ali follow..  14........................................................................................................................................................................SPDMGAVNSLCFQESRLLAGTIKGSVFLWDLQTN-----RSALHFEVGSDPITSLHHTPD--------RLVTQEKGGTITMFSIGGSSYVNHLGFCRSALHTNTSKTNEQLLFYPCEESSIGVLHVTDAAAPTQILVPDDPQLPKLGSVTC-------FKPFECASQLFLLAGYESGHFLT-----------------------DISSSVILDVMELAQDATSVDYDPVTNRGIVGGPTDKLISFSYQRSSMQMQLGSEL-CIKNPGVNGVRIDQKVFASAGWDGRIRIFSWKSLRPLAVLTQHKNG----GVMDLAFSSQQVAMPIMAAAGMQISLWDL.......................................................................................................................................................... 321
41 -24.000[R] KOG2394 WD40 protein DMR-N9  ali follow..  15.................................................................................................................SSSPAANPQSPGIKTYFKTPEGKYKLHYEKTHS-SGLLHYAHGKTVTQVTIAQLKERAAPSTPTGTSSGYSASSGFRSATARLLGTGNGSRALSSGSFAASNSNTSMTNTNFDGK-----GTYLVFNVSDAIFICDLNSQEKDPVKSIHFSNSNPMCHAFAKDGHDLLIGLNSGDVYTVSLRQQLQDVSKKLVGALHYNKDGSVNNRQDRCTSISWVPGGDGAFVVAHADGNLYNKDGATESTFPAIRDPTQFSVDKAKYSKSNPVARWHICQGSINSIAFSNDGAHLATVGRDGYLRIFDFLTQK-----LVCGGKSYYGALLCCSWDGKYILTGGEDDLVQVWSMEDRKVVAWG-----EGHNSWVSGVAFDSNWSSPNSFGSVGQQLLLWDLEMDEIVVPLRRAPGGSPTYSTGSSAHWDNVIPMGTLQPAPC-DVPKLSPIIAHRVHTEPLSGMFTQESVVTACREGHIKIWTRPSESETQTNSSEANPTTALLSTSFTKDNKASLSSKIISGST.............................. 553
42 -23.800[S] KOG0321 WD40 repeat-containing protein L2DTL  ali follow..  132..............................................................................................................................................................................CLGFANNESLLAVCTETGALELFDSRFYDRPSARRIHGWLAHNNAIFSVNF------SKDDSLLATSSGDQTSKVFDLSTQQCITRLGYHSHSVKQVNFCDSPYNLVSCSRDGSIIFWDMRTHGITIDGEHFQKPVLRIRKAHENSGRDCSITSATWLPQSTSQVISSCSANSALKLWDLRTVHTVRPLPAATTPELTTSK---------RDFGVTNVCTSPDGERIYAASRDSIIYEYSSRHNSGFCKTYKDPRLRISSFYVKLACDGATLACGGKTSGVVVFDTTRNCSSSAML----GGHTKDVTAVDWSSEGQ----LASISDSVRVWNSSLHGSAANLREKNFSE.......................................................................................................................................... 481
43 -23.700[ABO] KOG1446 Histone H3 (Lys4) methyltransferase complex and RNA cleavage factor II complex, subunit SWD2  ali follow..  10  29...............................................................................................................................................................................IDFAPNGEHLISCSEDDQIVIYDCEKGT-----QSRTVNSKKYGVDLIHFTHA----NNTAIHSSTKVDDTIRYLSLHDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLRSPNCQGLMHLSGRPIAADPEGLIFAAGVNSESIKLYDLRSFD-----------------------------------KGPFVTFKLNQEKECDWTGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPNNKGIPIEASFSPDSQFIFSGSTDGRVHIWNADTGNKVSVLN----GDHPGPVQCVQFNPK----MMLASACTNMAFW............................................................................................................................................................ 309
44 -23.600[D] KOG0267 Microtubule severing protein katanin p80 subunit B (contains WD40 repeats)  ali follow..  12  2...................................................................................................................................................................................................................SLCGHTSPVDSVAF------NSEEVLVLAGASSGVIKLWDLEESKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDTNLRVW---------------------------------------DTRKKGCIQTYKGHTRGISTIEF----------------------------------------SPDGRWVVSGGLDNVVKVWDLTAGK-----LLHEFKCHEGPIRSLDFLEFLLATGSADRTVKFWDLETFELIGTT-----RPEATGVRAIAFHPDGQTL--FCGLDDGLKVYSWEPVICRDGVDMGWSTLGDFCINEGKFIGCSYYRNSVG--------VSDISELEPYGAVSEDKNECMVKRFSVLNDQSERMGLNVAQNPGSLKATLPLESGKVATMVSEKQNAAYFGPAGDKYSSTSRDSDSGEESSYSERESIP.......... 368
45 -23.500[R] KOG1963 WD40 repeat protein  ali follow..  182.....................................................................................................................................NNLATVAVITTDKAIFSLNVPKKKRSQRWIHREHLFNMPQKLTNVSLCGSACAVSDDEGKIHVINDISNEKFNPQILH----HANPLNGLSW------ALNGEYLLSGGQEGVLVLWQMETSHR-QFLPRLGSSILSIATSHDSDSYALHLGDNSLVVIRAVDLAEQIHVSGINKYLTSTGPKNTSKQLQGLVQFSSVSPNGELLLMSSSHSVSVQEYDLTKDSTIRKFEAARYSYSSVSKNSDDATSLDNGHVGSVAVTSSRNGLYIATIDTQTALKFWQFDSVQKTWVLMTRIDNPHLEVVTALKMSSNRFITVGTDATLRIWNSETLEEISTVDLPHGG----QLENAQF---LNAEHCVIISQRRLLVWNVISASVQWTLASKFTGLLASSSSGNDFAVIDFNSSYSRLII------FSPDSPKIQSIHIFKTLPVALHYLHLDNKSIIH---VYAGDLTTKIPSAQLSIDNTSRSLLGDFQKRNVPLLNLENPISGSQGLHYKRLTTDMIHNLFNVPSNSPVNM 771
46 -23.200[R] KOG1524 WD40 repeat-containing protein CHE-2  ali follow..  17.......................................VCGVGWIGTEAILSAA----------DDHVFTNTATNESQQILNMPETFFPTSLHIFPRSQTSDGKINILSRNGKVENMVDAHNGAALCARWNSDGTGLLSSGED-GFVKMWSRSGMLRSV--------AQFATAVYCVAWTSSNVLYCNADHCYIKSLKMQVAPIK------WKAHDGIILCCDW------NPTSDLIVTGGEDLKFKVWDGKSGWSHSLEKMNAGSVMALSWSPDGTQLAVGTAAGLVFHAHIIDKREIVQTQKTVIEVRDVSSEVSRETLETKERISKIAILYKYLIVVTSSHIYIYSSKNWNTPTMIEYNERTVNIIVQKLINLNPPGQVMALLDERKIDLANDTLVVRDRADNKVLHFFDPTTGKA----QGDGNLKHEHDIVELTVNDRNVAFRDQIGAVHIAMVKTFGVSQRMVKIGSL-----VEQLVFNDVTNML--CGISEGKIAVWPLPNVAFHDRNGSVGKFPQLANFAGNTIVIRKSDGCLLPTGILPFYGTLITMASQSKAGLAVLHKNMIVMEIAYAALEDDEKVSLINEIKDKTDKETRQAMQVVLTGKLADADVLLERSGLSFRSLML------------QMFKWKRALELGLKN. 706
47 -23.100[A] KOG0284 Polyadenylation factor I complex, subunit PFS2  ali follow..  5.....................................................................................................................MMRGNQMPNVTLTIQPSTSSMQNSQPRIMN-VMGDGPGRRLRKNVANVRRHVDYVSTVLPDILYQQYAVPADSTPDVPVDCILTK-----FIRTAMNKVKCPVYSVCW------SPEGKRLITGCQTGEFTLWNGTAFNFETILQAHDSAIRALKWASNEQWLLSADQGGYVKYWQPNMNNAHMFSAHKDEAIRGAPTDVKFATASDDGTARVWDFARYTEERVLRGHGAEVRCIDWHPTKGLIATGSRPVKIWDPKSGSCLATLQEHKSSVMAVEFNKNGNWLLTGGRDHLVKMYDIRMMKE-----MRTYRAHKKEVISLAWHEGLFVSGGGDGSIVYWMVDGEKEIGLLE----HAHDQAIWSMKWHPL----HILATGSNNTKFWARNRPGDTVEDIFGLSNTNMIGHLDKEREPRMAPPKPS----------IETQETYRPDTFIPGMGLDEHLYEQLNRDHNMMTTDSTLLVPDDLTRQNFAPMIGAKRTLIKQPPAKKAQRQFERMWNNSKGIGAGSDDFTTMKGGLGR......... 553
48 -23.100[BK] KOG1063 RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily  ali follow..  187........................NPGRFALALGGLDNKIKLYSGERTGKFTSVCELSLDFSMLVSSSQIWKLVLVGDVGSWRREITLASYIEG-TFTYQISVESVLIGHEDWVYSVEWQPPVIDFIDGRLVNHQPLSILSASMDKTMMIWRPEKKTVNVVCVGELSHCALGFYGGHWSPNSLSILAHGYGGAFHLWRNVSSSKESEQMQKVPSGHFAAVTDVTW------ARTGEYLLSVSQDQTTRVFSAWKNDARPQVHGHDINCVAMVQGKGNHRFVSGAEEKVVRVFEAPLSFLKTLNHTCAGQADVQVLGANMSALGLSQKPIYLHSSSEPLERNGGGEGLDTFETVPEAAPAELKEPPIEDQLAFHTLWPESHKLYGHGNELFSLCSDHKGNLVASSCKAQSASMAEIWLWEVGTWKAVGRLQSHSLTVTHLEFDDTLLLSVSRDRHFSVFSIQRTDEVSHKLMAKVEAHKRIIWACSWNPFGHQF-ATSSRDKTVKIWSVENDARIKQILVLPPFGSSVTAVAWTGLDRNEKSGCVAVGMESGLIELSNVKIIETEEGTTATAALALRLEPFMCHVSAVNRLAWRPTEKCESNQSLRWLTSCGDDNC............................................... 832
49 -23.100[R] KOG0288 WD40 repeat protein TipD  ali follow..  13  194...............................................................................................................................................................................TLARQQVDGIVRRNEDGTDHFVESTIPSTCANRI----HAHEGGCGSIVF------EYNSGTLFTGGQDRAVKMWDTNSGTLIKSLYGSLGNILDMAVTHDNKSVIAATSSNNLFVWDVSSGRVRHTLTGHTDKVCSKFSSRHVVSAAYDRTIKLWDLHKGYCTNTVLFTSNCNAICSIDGLTVFSGHMDGNLRLWDIQTGKLLSEVAGHSSAVTSVSLSRNGNRILTSGRDNVHNVFDTRTLE-----ICGTLRASGNRLACISPDDDYVAAGSADGSVHVWSLSKGNIVSIL-----KEQTSPILCCSWSGI----KPLASADKYVCTWT........................................................................................................................................................... 515
50 -23.000[B] KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats)  ali follow..  12  489..............................................................................................................................................................................AVTISNPTRHVYTG-GKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLP------DGCTLIVGGEASTLSIWDLATPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCSNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLG------------------------------------------CPTGEWLAVGMESSNVEVLHVNKPD------KYQLHLHESCVLSLKFCGKWFVSTGKDNLLNAWRTPYGASIFQSKES------SSVLSCDISVD----KYIVTGSKKATVYEV.......................................................................................................................................................... 768
51 -22.900[U] KOG0277 Peroxisomal targeting signal type 2 receptor  ali follow..  13  4..............................................................................................................VCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTL-DPDEAGLRLFRSFDWNDGLFDVTWSEHVLITCSGDGSLQLWDTAKAAGPLQVY----KEHAQEVYSVDWS----QTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEIL------------------------------------------------------------------------------SCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPV----FELLGHTYAIRRVKFSASVLASCSYDFTVRFWNFSKPDSL----LETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYDPACLTIPA................................................................................................................................................... 323
52 -22.800[R] KOG0289 mRNA splicing factor  ali follow..  10................................EVPEHPCVHVYE-LSEEQLIDIKVAHPI-AILKALQDEWDAVMLHSFTLRQQTTRQELSHALYQHDAACRVIARLTKEAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEP-MDLGELVGMTPEIIQKL-------QDKATVLTTERKKRGKTVP--EELVKPEELSKYRQVASHV-GLHSASIPGILALDLCPS-----DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDE--------------------------------------TSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN-----VANFPGHSGPITSIAFNGYYLATAADDSSVKLWDLRKLKNFKTLQL----DNNFEVKSLIFDQS----TYLALGGTDVQIYICKQWTEILHFTEHSGLTTG........................................................................................................................................ 480
53 -22.800[A] KOG0640 mRNA cleavage stimulating factor complex; subunit 1  ali follow..  12  112...............................................................................................................................................................................GAFSCDGSLVATGSVDASIKILDVERMEQQGHPVIRTLYDHTDEVSYLEF------HPKEHILASASRDGTVKLFDIAKPSVKKKVFTDCEPVLCLSFHPTGDYVAIGTEHNVLRVYDVATTQCFVSAIPSQTCVKYSPTGKLYATGSYDGDIKIWDGISGRCINTIAEAH--------------------------------------GGAAICSLEFTRNGKYLLSSGMDSLVYLWELCTSRPIQTYTAGTTGKQEHQTEAVFNEDYVLFPDEATTSLCSWNSRNGCRLTLNSL----GHNGPVRYITHSPN----PAFLTCSDRARFWYRRANNQ..................................................................................................................................................... 424
54 -22.700[KL] KOG4283 Transcription-coupled repair protein CSA, contains WD40 domain  ali follow..  11  14......................................................................................................................................................................................RSNSFANRFKSRRILSLQLSNRKD-----FVSPHRGSVNSLQVD-----LTEGRYLLSGAADGSAAVFDVQRATDKQHENGHKYAISSAIWYPDTGLFITGSFDHYLKVWDTNTAQAVVDFK-----------------------------------------------------------------------------MPGKVYRTAMSSMAMSHTLIAAGTEDVQVRLCDIASGA-----FSHTLSGHRDGVMSVEWSEWVLYTGGCDGAIRFWDIRRAGCFRVLDQ--------SQTQLGFRPPILK---RTAVGS................................................................................................................................................................. 250
55 -22.600[S] KOG3914 WD repeat protein WDR4  ali follow..  7..........................................................................................................................................................................FKHPCQFLTWNSKNYIVCCSGPYLLGFSCSTGEDNINEKHREAAAYGEAIRQVAF------SKDYSRMATVSEDKCLRLWDSTQPDKIELLYQKPKRCADLCFAGSNEIVFGD-KFGDVYCVDE--------NWFTTSEVTEEKKSNVVEGKQEPVNNDTLKDSKLQKLEPIMGHVSILTQLIVAQNP-----------------------------------QNSKEEIIITSDKDEHIRISRFPNAFV----IEGFCLGHEDFVSRMSLDNRTLISGGGDNHVFVWDLENFKCLDAFDLRLSLNQPMVVSVILPIFKRQLVAFACEGMAGLIFAKVTPEKRLLFHSALKLSGP-VLLDTDTDQILISLDSSFTFGACFECVKFDEGNAAVLTKPDVIKRIESDGLISTEKPFCPLAQIHTLRKNHSKFIRSVETGTSSPSVESKDN............................................ 421
56 -22.600[S] KOG1409 Uncharacterized conserved protein, contains WD40 repeats and FYVE domains  ali follow..  10  6....................NQRVEQGESSMGGAKPALLHRITGHVARINDVILLSKDEGVWTASDDRSLYLAPTSLYYSEETYKLLVGLINGN-----VYEFSVADDFNSMT-ESRKWTCHAGPISGLGFALSSELIFSCSRD-KSIVWHCSENSNKMGSY-------LLENSCTAMVIDLPFVFVGDHGGHVTVLRIVDNQ---PNLVSKLSAHTNAITSLTW------DGNKKVLYSGSSDHLIIMWDIGGGREAYELNGHNGKVTTLCAAPAAKRLFSADEHGKLMCWDMNCKRVETPEWKTSDCCQKCNQP-----------------------------------------------FWNLQAMWQRKVVGLRQHHCRTCGSAVCGSCCDNWTTYPPMGYETKIRICNKDNPQNFNLTPLAIPHEIHTGITAMHLTLGLLVTSGQNRVIMIWDVRSVCSAPS.................................................................................................................................................................................................. 412
57 -22.500[S] KOG0283 WD40 repeat-containing protein  ali follow..  11  361...............................................................................................................................................................................TDSPKKGKDHKHGKANEWVKVRPTGKSYKSALHMCQEIQAHEGAVWTIKF------SQDAHYLASGGADRVIHVWEVQECELMSMNEGSLTPIHPSLCDSSGNEITVVEKKKKGKGSSGRRHNHIPDYVHVPETVFSFSDKPVCSLKGHLDAILDLSWSKSQLLLSSSMD--------------------KTVRLWDIETKTCLKLFAHNDYVTCIQFSPVDENYFLSGSLDAKIRIWSIQDRH------VVEWSDLHEMVTAACYDGQGALIGSHKGICRAYDTEDCKLSQTVQSNKKSQAKRKITSFQFSPVNPSEVLVTSADSRIRILDGSEVIHKFKGFRNTCSQLSSQDGKYIICASEDSQVYLKNDFHRTRSTLTTQSHEHFHCKDVSAAVPWHGHVRGEPPPVQ--IHSKRHSKRISTSSQPSSTISSPTKEETSATGPTTSNRNKKSGLPPMPKKAATKSQIQPEEEAGPELGSS.... 821
58 -22.300[A] KOG0647 mRNA export protein (contains WD40 repeats)  ali follow..  11  1..............................................................................................................................................................................MSFFNRSNTTSALGTSTAMANEKDLAND-------IVINSPAEDSISDIAFSPQ-----QDFMFSASSWDGKVRIWDVQNGVPQRAQHESSSPVLCTRWSNDGTKVASGGCDNALKLYDIASGQTQQPIKVLRFVQCGPSNTECIVTGSWDKTIKYWDMRQPQPVSTVMMPERVYSMDNKQSLLVVATAERHAIINLANPTTIFKATTSPLKWQTRCVACYNEADGYAIGSVEGRCSIRYIDDGMQKKSAPGSNGQSLVYPVNSIAFHPLTFVTAGGDGTFNFWDKNQRHRLKGYPT-----LQASIPVCSFNRN--SVFAYALSYDWHQGHMGNRPDYPNVIRLHATTDEEVKEKKKR................................................................................................................................. 365
59 -22.200[R] KOG0645 WD40 repeat protein  ali follow..  11  1.......................................................................................................................SGHTGRLWSVAAHPMLPLFATSSQD-KSVRIYNSNTYNLVHVI-----DGFHTRSIRRVAWRRPVLAVASFDSVVSINEKIDDD----ECTAALEGHENEVKCIAW------SCNGNYLATCSRDKSVWIWEADEFDCLAVLQEHTQDVKVVTWHPTEDLLVSGSYDNSICFWRDDGDD---------------ALTCQLQGHTNTVWALAFSPNGNTLASADNDGNVFLWIKISSNEDVATIDSTNILRPALQEEWKQQTSLPHIHKGAVYTISWMNDATLCSAGGDGKIVVYQREKHDEALWHVEQDHAHGVYEINSLEYLDDRLLSGGDDGECRVWSF.......................................................................................................................................................................................................... 321
60 -22.100[R] KOG0315 G-protein beta subunit-like protein (contains WD40 repeats)  ali follow..  10  19..........................................................................................................KVWQTGNCIKTMRFVETSQVNALDRTPDKTRLAACGYQC--IRLYDLESNCTAPVINFDGVQKNVTR--LGFQEDGNWMFTAGEDHHVRIWDMIAAPPHCSRIF----DCEAPVNAACL------HPNQVEIAMGSQNGSVFLWDVKSERHERIVPEVDASIQDVAISPDGRYLAAANNKGNCYIWS---------LTSQDQKMSTLRPNRKIPAHSRYILRCKFSPDSRLLLTTSGDGTVCI----------------------KTDDFSKWRELCIENYWVWDAAFSADSKWLFTASSDGIARLWKLQTKS-----SIRDYTGHTKAITALSFEIPVKSTNISDVQSSAKPPTQRD-----------NPPGTNNLAFFETVG-RVAMNPYMGNTTTELN........................................................................................................................................................... 362
61 -22.100[R] KOG1334 WD40 repeat protein  ali follow..  183VELESMGEGLFGYPLPRMCPRCGGTNHDQCLLDEDQALEEWISSETSALPRSRWQVLTALRQRQLGSSARFVYEACG------------------ARTFVQRFRLQYL----------LGSHAGSVSTIHFNQRGTRLASSGDD-LRVIVWDWVRQKPVLNFE-----SGHDINVIQAKFGDSTLAMCGHDGQVRVAELINASYCE--NTKRVAKHRGPAHELALEPD-----SPYKFLTSGEDAVVFTIDLRQDRVVTRENDKKVGLYTISMNPANYQFAVGGHDQFVRIYDQRRIDKKENNGVLK---KFTPHHLVYCDFPTNITCVVYSHDGTELLASYNDEDIYLFNSSLSDGAQYVKRYKGHRNNDTIKCVNF----------------GPRSEFVVSGSDCGHVFFWEKSSSQ----IIQFMEGDRGDIVNCLEPHP-VLATSGLDQHVRIWTP-TAKTATELTG-----LKDVIKKNKQERD-EDNLNYTDSFDNRMLRFFVRHLLQRAHQPGWRDHGAEFPDEEELDESSSTSDTSEEEGQDRVQ............................................................................................................. 677
62 -21.700[S] KOG4328 WD40 protein  ali follow..  13  213..........................................................................................................................................................................VPGRIFVVQFNVKMVAAGDKLGNVGFWNLDCGNEEDNDGIYLFTPHSAPVSSIVFQQN-----SLSRVISSSYDGLIRLMDVEKSVFDLVYSTDEAIFSLSQRPNDEQSLYFGQDYGVFNVWDLRAGKSVFHWELHERRINSPQNPHVMATSSTDGTACLWDLRSMG------------------------------------AKKPKTLSTVNHSRAVHSAYFSPSGLSLATTSLDNYIGVLSGANFENTCMIYHNNTSRWISKFKAV--DDSYIYVGNLSKKIDVINPKLKRTVMELHNPLQRA----PCRIHCHPYNVGTLAGSTAGGQVYVWT........................................................................................................................................................... 514
63 -21.600[R] KOG2055 WD40 repeat protein  ali follow..  223...............................................................................................................................................................................MSIHPYFPLLLTCGFDRTLRIYQLDGKVNP---LVTSLHLRSSALQTALF------HPDGKRVIAAGRRKYMYIWDLESAQVQKVQENFQPSMERFHVDPTGKYIALEGRSGHINLLHALTGQFATSFKIEGSDVLFTSDGSEMLVLSYGAEVWHFNVEQRSVVRRWQVQ---------------------------------------DGVSTTHFCLDPSNKYLAIGSKSGIVNIYDLQTSNADAAPPVTTLDNITFSINSMSFDSQVLAIASRKDTLRLVHVPSFSVFRNW--PTSATPLGRVTCLAFGKG-----GELCVGNRVGLWKLAHYDLKFVPDKIINWEIRLGKFGYVLLGIQILILHVDVVI.................................................................................................................. 555
64 -21.300[A] KOG0272 U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats)  ali follow..  14  267...............................................................................................................................................................................AAFSEDSSLLLTSSWSGLCKLWSVPDCE-----LKQTLRGHASYVGGVALRGVKADEENVVAMASGGHDGAVKLWGFNNEESIADITGHPHRVSKVAFHPSGRFLATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDF----------------------------------------SPNGFHIATGSQDNTCKIWDLRRRQP-----VYTIPAHTNLISDVKYQGSFLVTCSYDSTTKIWSNKTWQPLKTL-----QGHDNKVISVDIAPN----QYIATTSRTFKLWSPDS........................................................................................................................................................ 553
65 -21.200[R] KOG4227 WD40 repeat protein  ali follow..  52..........................................................................................................................................................................HFGCVNAIEFSGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAF------NSGNTKVFSGGNDEQVILHDVESSETLDVFA-HEDAVYGLSVSVNDNIFASSSDDGRVLIWDIRESP--------------HGEPFCLANYPSAFHSVMFNPVEPRLLATANSKEGV---------------------IRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQ--YFNSCTMKSCCFRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGGHRSIVNQVRFNPH----YMICSSGKIIKIWSPYKQPG-DGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQEDPRMMAFFDSLVRREIEGWSSDSDSDLSESTILQHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQ. 520
66 -20.900[D] KOG1036 Mitotic spindle checkpoint protein BUB3, WD repeat superfamily  ali follow..  13  14.......................................................................................................................NPPSDGISNLRFSNNSDHLLVSSWD-KRVRLYDVSTNSLKGEF-------LHGGAVLDCCFHDDSGFSVGADYKVRRIVFNVGKED------ILGTHDKAVRCVEYFDFSILCDVTGQVITGSWDKTVKCWDPRGASGPERTQTYLQPERVYSMSLVGHRLVVATAGRHVNIYDLRN-----------------------------------------------------------------------------MSQPEQRRESSLKYQTRCVRCYPNGTGYALSSVEGRVAMEFFDLSEAAQAKKYAFKRDIVYPVNSIAFHPGTFATGGCDGFVNIWDGNNKKRLYQYS-----KYPTSISALSFSRDGQLLAVASSYTEAIFVRSVNEIEVKPKPKVYPNPAA......................................................................................................................................... 354
67 -20.900[R] KOG2096 WD40 repeat protein  ali follow..  8......................................................................................................................................GIASVILGALIAVLFFGSYFRKRTSE----VQSMAKAEPQDPIRNPKSNHPAPKKNHPKSQASDKNQNKRHHPLDLNTLKGHGDAVTGLCF------SSDGKSLATACADGVIRVFKLDDASSKSF--NRWEFTLQAHFHDLTVFFVCFLKFRFLRINDASSIVVACHHMSGSSLYMYGEDKQKDQQGKLPLPSIKWDHHHIHEKRSVLTISGATATTADGSVVIASCSEGTDIVLWHGKTGRNLGHVDTNQLKNHMAAVSPNGRFLAAAAFTADVKVWEIKDGSVKEVSRVMQLKGHKSAVTWLCFNSEQIITASKDGSIRVWNINVRYHLDEIPLCDSGGNPLHYDRLSLCPEGKIL--AASHGSTLQWLCAETGN...................................................................................................................................................... 401
68 -20.900[R] KOG1310 WD40 repeat protein  ali follow..  14...............................................................................................................................................................................LLHTRSQDPSHEVDQRMQFHSSLVRR------SQEQELEGHQGCVNALAW------NSNGSLLISGSDDLRINIWNYSSRKLLHSITGHTANIFCTKFETSDELVVSGAGDAEVRLFNTSRLSGRAEDDNAIIPS--------------------------ALYQCHTRRVKKLAV------------------------------------------EPGNPNVVWSASEDGTLRQHDFRESTSGAKRALADPPKQTLSLKSCDISATLLLVGGSDAFARLYD------RRMLPPLASSRTNLHLTHVTFSPNGEEV-LLSYSGEHVYLMNVNNGTGIMQYTPGDVDNLFSFSNNLHDVESPPQVSTTPQNGFHRSSNAATVKKCTELVEIAKWSLEEGTDVFYAIEAANEVLDAHSNDIESALRHECLCTRAALNDAHMAVRDCHNARRIDASSFKAHYYMSEALQQLGKCKEALDFATAAQHM. 468
69 -20.900[Y] KOG4714 Nucleoporin  ali follow..  12  27....................................................................................................................................................................................QSERFVTGSWDNFVRLWRLQSNQYVTATRCMDKVRMEDDVTAMEFV-------DKDTLAVSCADGHLSVFNVHRAGRLHCFQRSQEPAPCTDLSVYGTDIATAGEDGCVSIVS-------------------------------------------------------------------------------VENVRQVKRQIEADSMALFSICYISQQELVTANRMGVIRMLDARVATEAQPKMVASQDDKSNFVSSLAKHQHILLCGSEEGSITVWDMRNLSY----PASYLSAHKSPINEIGFHQKDPSKLFTAAEGGEVWMWSE--------NKVLGCDYNKDGHSPWLSGDRVRSLVDVEGVLSNVRKSINS-------------DVHGSRLVCGGDTEAVYLVDNIV..................................................................... 358
70 -20.700[E] KOG0280 Uncharacterized conserved protein  ali follow..  11  63....................................................................................................................................................................................DASVLAVAHSTGHVSFYRHQFRAELMFLRGIKVADSSVLMLSLDF------SDSGKELAVSMSNGSVLIIDIDSGVIKNKWKEHDYEAWTCHYSRDNNLLYSGGDDAALVCYDQRI-----------------------------------------------------------------------------NSCIWRDIQVHHSGVVSILSRAPFGPYIATGEYGDFMHTLDTRNIGKPLF-----SANLGGGVWRLEHMEHKVLGILMHRGAQVLRISNDFSSIDASKRIFKEHESMCYGGDWRHTDGLLATCSFYDKRVCLWED.......................................................................................................................................................... 309
71 -20.600[R] KOG1188 WD40 repeat protein  ali follow..  34...............................................................................................................................................................................TVQAGKENLVAVLCSNGSIRIYDKERLNVLR-----EFSGYPGLLNGVRF------ANSCDSVYSACTDGTVKCWDARVAKPVQLFKGYPSIFISFDINCNDHIICAGTEDALLVFWDA-------RMNSQNLSTTKDSLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDN----------------EEDALVTTCNSISSVSCIGWSGKGYKQIYCMTHDEGFYWWDLNHLDQDVREVVNMKEDALDYLIGGLYDTLHVIGGTNKGRIHLMNCSMSGLTHVTS--LQGGHAATVRSFCWNVQD---DSLLTGGEQLLLWKPGAIEKTFTKKESMKIASSVHQRVRVHSNDSYKRRKKQ..................................................................................................................... 387
72 -20.400[Z] KOG1523 Actin-related protein Arp2/3 complex, subunit ARPC1/p41-ARC  ali follow..  14...............................................................................................................................................................................HAWNRDRTQIALSPNNHEVHIYKKNGSQ----VKAHELKEHNGHITGIDW------APKSDRIVTCGADRNAYVWSQKDGKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFEA---------------------------------------------------------------------------ENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKKSEFGGSGTGGWVHGVSFSGSRLAWVSHDSTVSVADASKSVQVSTL-----KTEFLPLLSVSFVSENS--VVAAGHDCCPMLFIYDDRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQG.............................................................. 366
73 -20.300[DO] KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits  ali follow..  129..............................................................................................................................................................................LNLLDWGSANVLAIALGDTVYLWDASSGSTSE---LVTIDEDKGPVTSINW------TQDGLDLAVGLDNSEVQLWDCVSNRQVRTLRGGHE-SRVGSLAWDNHILTTGGMDGKIVNNDVRI--------------------------------------RSSIVETYLGHTEEVCGLK-----------------------------------------SESGNKQASGGNDNVVHIWDRSLASSQTRQWLHRFEEHTAAVRALAWCASLLATGVGDGKIKFWNTHTGACLNSVETGS------QVCSLLWSQSEREL--LSSHGNQLTLWKYPSMSKMAELNGHTSRVLFMAQSPNGCTVASAAG---DENLR---------NVFGEPPKTTKKAASKKYPELFSHVNSLR........................................................................... 444
74 -20.100[YU] KOG2445 Nuclear pore complex component (sc Seh1)  ali follow..  11  15...............................................................................................................................................................................VVYDFYGRHVATCSSDQHIKVFKLDKDTSN--ELSDSWRAHDSSIVAIDWASP----EYGRIIASASYDKTVKLWEEDPDNKLCTLNDSKGSLYSVKFAPAHLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSIS----------------APSIGRWYQLIATGCKDGRIRIFKITEKLSPLAELLSEHDDHNGEVWSVSWNGTILSSAGDDGKVRLWKATYSNEFKCMSV............................................................................................................................................................................................... 344
75 -19.900[T] KOG1354 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  1.........................................................................................................................................................................................MAGAGGGNDIQWCFSQVKGAVDDDV----AEADIISTVEF------NHSGELLATGDKGGRVVIFQQEQENKIQSHSRYNVYSTFQSHEPEFDYLKSLEIEEKINKIR-----------------LPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADD-LRINLWHLEITDRSFNIKPANMEELTEVITAAEFHPNTFVYSSSKGTIRLCDMRASALCDRHSKLFESEIISSISDVKFSHS----RYMMTRDYSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKF-----ECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNN........................ 438

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.