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Query: [OT] KOG0505 Myosin phosphatase, regulatory subunit, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFSSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKNLHQLKQIQTLKQMNEQLQAENRALTRVVARLSESIESSDTQELLast
1 -234.000[OT] KOG0505 Myosin phosphatase, regulatory subunit  ali  100  1MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFSSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKNLHQLKQIQTLKQMNEQLQAENRALTRVVARLSESIESSDTQEL 998
2 -66.300[R] KOG0508 Ankyrin repeat protein  ali follow..  13  2.....AEGSMN---PKLLDTWIIHWEQQQTEMKLVFKNIPYKPAQTKIFQ--------GVRLNFAGVKSPHETLQVLFQQLGEIPNTSQEGLPPHPCMALRESFLSTCYCEAFNPSSPPCHKQGLTQGLLLLLCGLVEPVGLVPVATAGGRRGDAAAHRRLLRPPGRGGVPGGPVRRERGGRWLGALRWRDRGGCHLDVVRSLLRRGASVNRTTRTNSTPLRAACFEGLLEVVPYLVEHQANLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNWRSAKGNTALHNCAESSLEILQLLLGVTGHTNEQPGQEQVTGVEAQPGLPQEGSSTSQGCRQPQGAPCCIFSPELNRESYQSCCPTSREAAVEALELLGSTYVDKKRDLLGALKHWRRAMELRHQRVEYLPKLEPPQL----VLAYDYSREVNTTEELEALITDPDEMRMQALLIRERILSPSHPDSSYCIRYRGA............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 497
3 -65.300[R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain containing proteins  ali follow..  16  2.....EGPGLGSQCRNGPHPPGFGRYGICAHENKELANAREALPLIEDSSN--------CDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVRFYISKGAVVDQLGGDNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPII-AYLISKGQSVNMTDVNGQTPLMPEPTGFLLKFNPSLNVVDKHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLKTEAKMRANQKFRLWRWLQKCELFLLLMLSVITMWAIGYILDFNSDSWLLKGCLLVTLFFLTSLFPRFLVGYKNLVYL........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 347
4 -56.500[R] KOG0514 Ankyrin repeat protein  ali follow..  18  92VRSIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENERPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLALEKYLDNPNALTERELKVAYTTVLACRSDAHPELVRRHLVTFRAVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVSCDISLTDRDGSTALMVADAGQSEIASMLYSRMN.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 443
5 -56.300[E] KOG0503 Asparaginase  ali follow..  17  345..TQCPNGTVAEIYDTGKVLCDVGVIPGFDMTPEAALAKLAYVIGKEEWSLDELTSLKAPKMEDYDLVDAVARSLHLSSPQELDQLGETLFPAMINAAVAEGDPKKINNLKAYGADLSGTNHDQRTALHLACQLGNVEIVKYLLQNGVSVHVRDRYDRTPLLEAVATDSHEII---------------------------QLLINCGAHLTGSSRAVGEQLCAAAARGSMIRLKSYQYAGADLAQSDPSGRTALHVAALHGFPEVVQYVLPYFENPNEKDMLGLTAMDYAERGHAAVMEVLKS....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 631
6 -52.300[O] KOG4412 26S proteasome regulatory complex, subunit PSMD10  ali follow..  24  2.......................................EIATDTAKQMRD--------EELFKAAEWGDSSLFMSLSEESKSLNFRNEDGRSLLHVAASFGHSQIVKLLSSSDTVINSKDDEGWAPLHSAASIGNAELVEVLLTRGADVNAKNNGGRTALHYAASKGRLEIA---------------------------QLLLTHGAKINITDKVGCTPLHRAASVGKLEVCEFLIEEGAEIDATDKMGQTALMHSVKVSMDQVAFLLIRHGADVDVEDKEGYTVLGRATPALIDAAKAMLEG...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 247
7 -48.500[R] KOG1710 MYND Zn-finger and ankyrin repeat protein  ali follow..  13  7........................................................APKSPLFEAIDKNDTEAALALLKTKEQAAQRDPSGMSVLAAAAYRGNLTLVEKAIELKCDVNDKDGTLYTPLMFAALSGKQDVCRLLMDSGARMYLVNGIGKTASELAAFVGHHECVA--IINNHITIDVIEDLLRPKVNGKYEG---------EEYPDELAVFIHSLCGSHEIHPVKIIFRFSK----------YPDSLKYKKKILYVIDRVFEKQLRCKESNEIMSLKLWLILFSMRETSKFVESNKEK--SPEEASLQYAKLISTWQEGDETRRALDVMLRNAVA--QKSQIGERPSAYEYIVQALFGQRIAAV................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 317
8 -47.400[R] KOG2384 Major histocompatibility complex protein BAT4, contains G-patch and ankyrin domains  ali follow..  10  1...........MNSQNELHPNWLALTTLPLQLKRFVRAGDPDFIAESPKAEAREFYKEVLDAPTTCQPNLPSTHKTAQTRREPERILVPFDKSKFFRLATSNKVEELSQMKASEEDLNSRDSFGWTALMMAACEGATEAVSWLVQRGVQVETSDKSGNTALKLAQRKGHLDVV-HLLESLPILEE----------------------TSEEDESVDGNNPFYCEICKRDYKETPWPIHQTSTVHQFNLKALPKLHKFNISAKNRGLQLMVKQGWDQEH--------LGPSQSGRLYPVKTVLRKQRTLGIEQQSARVSHFGAFDLNAVRRRDPIYQPRRTRSDMQREKVREWKRE................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 328
9 -46.700[E] KOG1709 Guanidinoacetate methyltransferase and related proteins  ali follow..  13  2........................................................EEADQLCLAAKSGDLKKVQTLIYSGADVTHFDNDGLTPLMHAAKIGNAEIVTALLESGAPWNALSPSNLSAGDFAMEAGHQETFDLLLKTGIQSELILGTIARNQTKNEYSNQEYLQDRVSFSEDKLMD----------------------SESKGVMMAWEKPLMEAHAKAICLNGGHILNVGFGMGLVDTQRYNPVKHTIIEAHPEVYKRMIESGWG----EKENVKIVFGRWQ---DVLDKLDDNSF------DGIFFDTYGEYYEDLREFHQHLPRLLKPDGVYSYF-------NGFCGSNAFFHVVYCNLVTLIENLGFSTQLIPLPVKDCLGDEV......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 303
10 -46.600[I] KOG0817 Acyl-CoA-binding protein  ali follow..  16  3..........................SSFLPAGAITGDSGGELSSGDDSGE--------VEFPHSPEIEETSCLAELFEKAAAHLQGLIQVASREQLLYLYARYKQVKVGNCNTPKPSFFDFEGKQKWEAWKALGDSSPSQAMQEYIAVVKKLDPGWNPQIPEKKGKEANTGFGGPVISSLYHEETIREEDKNIFIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEVTGKTVSLVLQRHTTGKA.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 282
11 -45.200[R] COG0666 FOG: Ankyrin repeat  ali follow..  12  296...........NVDYSLLKWSNDHVINQSVAIIPALPKEQLLMLKGTVDEITPPLSPATNLLMAIGQNHQLKQLMIQLQKMPELTAYNSINLPGLYLAINYGNADIVETIFNSLSELEAKDKNGFSGLFLAISRKDKNVVTSILNALPKLAAKNSTSSHVLYHVMANGDADML-KIVLDALSLLIRTCHLTKE----QVLDLLKA-------KDFYGCPGLYLAMQNGHSDIVKVILEALPSLTAKSLARDTGLFMAMQRGHMNVINTIFNALPTLLANNSNEYPGLFSAQHKQQNVVEMVYLALSDHARLFQHKAPQKYSAFELACELGHRVIAELIFNTLNKMAESF----GFTDNPRYIAEKNYMEALLKKASPHTVR......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 728
12 -44.100[T] KOG4335 FERM domain-containing protein KRIT1  ali follow..  13  41..VINPYFGLG-------APDYSKIQIPKQEKWQRSMSSVTEDKERQWVDD--------FPLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGCNPNLLNGQLSSPLHFAAGGGHAEIVQILLNHPTDRHITDQQGRSPLNICEENKQNNWEEAAKLLKSENLSLQLKPYHKPLQAELTNLDPQRETPQLFLRRDVRLPLEVEKQIEDPLAILILFDEARYAPDAKLITLASLLLQIVYGNYESKK---HKQGFLNEENLKSIVPVTKLKKAPHWTNRILHEYKNLSTSEGVSKE-------MHHLQRMFLQNCWEIPTYGAA.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 431
13 -42.700[PT] KOG3676 Ca2+-permeable cation channel OSM-9 and related channels (OTRPC family)  ali follow..  11  1............................................................MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFPHEEGELDSCPTITVSPVITIQRPGDGSTGARLLSQDSVAASTEKTDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLPETGKTCLLKAMLNLLLE-NASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGGELPLSLAACTNQLGIVKFLLQNSADISARDSVGNTVLHALVE-VTSMYNEILILGAKLHPTEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECR----HLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSV..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 396
14 -35.000[T] KOG2209 Oxysterol-binding protein  ali follow..  13  1.....................................................MNTEAEQQLLHHARNGNAEEVRQLLETMARNESKSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVTHAEEIRSMLE---------------------------------AVERTQQRKLEELLLAAAREGKTTELTALLNNPPDVNCSDQLGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQGAEMKHI--------VGNKVIYKALKRYEGPLWKSSRFFGWRLFWVVLEHGVLSWYRK----QPDAVHNIYRQGCKHLTQAVCTVKSTDSCLFFIKCFDDTIHGFRVPKNSLQQSREDWLEAIEEHSAYSTHYCSQDQLTDEEEEDTVSAADLKKSLEKAQSCQQRLDREISNFLKMIKDMAKEMLPSFLQKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELEQSLVKGSPPASILSEDEFYDALSDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCMELSKITMPVIFNELSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYEDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNINHKTGDKCVLNFKPCGKELHKVEGYIQ----DKSKKKLCALYGKWTECLYSVDPATFDAYDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRI-RPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKK--RLEEK-------------QRAARKNRSKSE..................... 911
15 -33.900[R] KOG1595 CCCH-type Zn-finger protein  ali follow..  13  1...............................................................MCGAKSNLCSSKTLTEEFMRQKSEDGASATCLLEFAACDDLSSFKREIEENPSVE------------------IDESGFWYCRRVGSKKMGFEERTPLMVAAMYGSMEVLNYIIATGRSDVNRVC-------------------------SDEKVTALHCAVSGCSVEIIKILLDASASPNCVDANGNKPVDLLAKDSRFVPNQSRKAVEVLLTGIHGSVMEEEEEELKS................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 191
16 -32.500[T] KOG0195 Integrin-linked kinase  ali follow..  17  3...........................................................DIFHWCREGNSIQVRLWLDETEHDNNLGDDHGFSPLHWVAKEGHAKLVETLLQRGSRVNATNMGDDIPLHLAAAHGHRDVVQMLIKERSDVNAVNEHGNTPLHYACFWGYDMIC---------------------------EDLLNAGAQVGIANKDGHTPLEKAKPSLAKRLQDLVEKSGREVKVISFKEQSWQGLKTRSRDATLSRFKGISMGDLDLHTKLSVTPSGET-QKNDVVAKILAVRQCTPRISRDFNEE......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 237
17 -31.200[R] KOG0522 Ankyrin repeat protein  ali follow..  11  2................................................................................................................ASSTIDV-TKYGHSPVHHAVVTRDYAGLKKLLSALPKMRDPSEVQNEAASVAEETKADSIAAVI---------------------------------DRRDVVNRDTALHLAVKLGDETSAEMLMAAGADWSLQNEHGWSALQEAICGREERIAMIIVRHYQPLAWAKWCRRLPRLVATHRMRDFYMEITFHFE----SSVIPFISRVAPSDTYKIWKRGANLRADMT--AGFDGFRIQRSDQTILFLGDGSEDGKVPSGSLLMISHKDKEIMNALDGAGAAASEEEVRQEVAAMSKTSIFRPGIDVTQAVLFPQRQEKTEMVGQWKAKVYDMHNVVVSIKSRRVPGAMTDEELFSNTNQENDTESEDLGDILTEDEKRQLELALKLDSPEESSNGESSRISQKQNSCSFEDREIPVTDGNGYCKQEKKGWFSGWRKREEGHRRSSVPPRNSLCVDEKVSDLLGDDDSPSRGGRQIKPGRHSTVETVVRNENRGLRDSSKASTSEGSGSSKRKEGNKENEYKKGLRPVLWLSERFPLQTKELLPLLDILANKVKA-------------------------------------------RRLRELMTTKLPSGTFPVKVAIPVIPTIRVL--------------------------------------------------------------------VTFTKFEELEAIEDESSPTSSVKNSPREETQSSSNPSSSWFQWIKTPSQRPSTSSSSGGFNIGKAENDQDRGYNWITAEEKKKKVQEKNKAKKGKLPKLKLLNMSNIFAISNIRPAYF--PLFKAFLGLRLDLEVETARLAGDGSAASPAVSLRR-SSSEAKLT----FVCRVINNVVRTSS-P..... 754
18 -24.600[R] KOG0511 Ankyrin repeat protein  ali follow..  16  2...................................................................................ADKLMDKNFEELCYSCRTGDMDNVDRLISTGVNVNSVDKFDNSPLFLASLCGHEAVVKLLLQRGAVCDRDRYEGARCIYGALTDTIRDTLLSYDISKAVDVKQPFATHISSMYNDITFRVSNGKAEKMVNEWAKHEIVSLEVRPDIFDIFLKFLYLIPILHQIEPGQYEELIELSSKFDIELLPEFLDKARH................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 216
19 -21.600[T] KOG0521 Putative GTPase activating proteins (GAPs)  ali follow..  19  647........................................................DANQLLYMASVVHNLPVMCMAFALGADKMWKNPQQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGKKALDIAVDQENADIV-TLLRLTQLNDEIGPNDEYNGEDETYKNVMKD......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 796
20 -19.700[R] KOG2505 Ankyrin repeat protein  ali follow..  11  366........................................................KRQAEIEKEIRQSRLQEEERKKKKLAKYTEVIISNLKASNIEAFLEYLRSNDLSINFQFYPKNVHLHTSTPLHYAVTQKNAKLVAKLLRNGADPAMLNGNGKTPFEISTGNKEVKDE--LIARHELGESF------------------------------DWEAAKVGAPQSREQIQKQRQKAKTKLENQRRDKERQEELRRKEAMQKIEEQSKRDYDKLHGEGHSLGINNVRKVDELQSLSPRIEREKRAAAAMKRMQTK......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 600
21 -16.200[T] KOG0818 GTPase-activating proteins of the GIT family  ali follow..  19  137.............................................................LHSSVRTGNLETCLRLLSLGAQANFFHEKGNTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQM...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 252
22 -15.300[T] KOG0705 GTPase-activating protein Centaurin gamma (contains Ras-like GTPase, PH and ankyrin repeat domains)  ali follow..  22  482...IHRSLGTRLSRV---RSLELDDWPV--ELRKVMSSIGEKSTREEKERWIRSKYEEGQQLLRATADEDLQTAILLLAHGSREEVGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 663
23 -13.600[R] KOG4227 WD40 repeat protein  ali follow..  8  548................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANNNGQNLGEL-EVVAYDNSSLTGTLLHKD-----SEMACETPNAGTREDPTDTPATDSSRAHGHSGLKRQRIELEDT---------------------SENSS-----KKL-KT......... 942
24 -13.100[K] COG5164 Transcription elongation factor  ali follow..  13  2...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SDNSDTNVSMQDHDQQFADPVVVPQSTDTKDENTSDKDTVDSGNVTTTESTERAESTSNIPPLDGEEKEAKSEPQQPEDNAETAATEQVSSSNGPATDDAQATLNTDSSE-------ANEIVKKEEGSDERKRPREEDTKNSDGDTKDEGDNKDEDDDEDDDDDDDDEDDDDEAPTKRRRQERNRFLDIEAEVSDDEDEDEDEEDSELVREGFITHGDDEDDEASAPGARRDDRLHRQLDQDLNKTSEEDAQRLAKELRER-YVPQRFLLPSVDTATIWGVRCRP-LKKKFNLDRAMGKKKLKIIYIEAPKQSVIEKLLIPVQELPLLLGDLAMVDQISENNLE------VMLKIVPRLD........... 421
25 -13.000[R] KOG2295 C2H2 Zn-finger protein  ali follow..  10  245...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DSSQADALIRVLDTCVIKLEGGTDEDLKVLDEKPKDPVVYERKAEQMQSVKEVEKTINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQ-----SPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVVETETIDLDKVKDGQPRALHRTSSIFLRNTRSEIEAVCNRFSG----RVAIAD-RRWYRRG--MRDVNIKEICWGLNNVRPANGITAHKQVVRSDIKLCAKIALNLDEKFRL...... 631
26 -12.500[K] KOG4796 RNA polymerase II elongation factor  ali follow..  10  276...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SEIDRRSLESVLSRKLNPSQNATGTSRSESPVCSSRDAVSSPQKRLLDSEFIDPLMNKKARISHLTNRVPPTLNGHLNPTSEKSAAGLPLPPAAAAIPTPPPLPSTYLPISHPPQIVNSNSNSPSTPEGRGTQDLPVDSFSQNDSIYEDQQDKYTSRTSLETLPPGSVLLKCPKPMEENHSMSHKKSKKKSKKHKEKDQIKKHDI----------ETIEEKEEDLKREEEIAKLNNSSPNSSGGVKEDCTASMEPSAIELPDYLIKYIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQRKRLSPGSKEYQNVHEEVLQ--EYQKHEEKYRCEYLHNKLA----IK--------------------RLIGEFDQQQAESWS... 640
27 -11.400[K] KOG0709 CREB/ATF family transcription factor  ali follow..  15  186................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HQNSNGLVRFKSSQPRVLNPASISLNAPSSSFNPQSTSSTPATSSSSSSSTNGGFVKSSTGEDEEEIKL---CKKEGICLPDFFPLTKAE--------ERDLKRIRRKIRNKRSAQTSRKRKQ-QLEDRVSESTKENQAL---QQIERLSSENQSVISQLKKLQAQLGQNAKRTTQAGR... 363
28 -11.300[TU] KOG3895 Synaptic vesicle protein Synapsin  ali follow..  9  523...................................................................................................................................................................................................................................................................................................................................................................................................................................RSSISEVPEEPSSSGPSTVGGEIANKKRGRTASETSSGSGPGSVPSSAGPGSGFSSSFLGKQFSFAGKGEGVISTQPTQRPSEEPPAIPTTASSAVRPESSVSVSDSRNTDTLTERAGAGYQPVTNYEQQERVNPFDKEPSKSGSAASIHTSSSSSISSSSISSRINRNGNAIQSPPPPAGPPPPPPTNVTAVGSNANSSSGYRNSFSSSLSKDKTSYGNYGSTTSVETITRMDTNTTNIGATATEAGEASGVTAITNISNSDGIVAPTTGTITTSVTTNDWRSAIGMRSASVYSAPAAVTTVLPGDTSGYDSNSIASQGEGLNNPSDLPSYTRPSYSRSESNASKHSDLDVIFGDSKTTPASYGNGKYTRAAGSISDADMIFGGPPSNYKTDRFGASKSMSMTSGGVGSGNGSGSGLGGYKIYDSIQNAAFSDFSDSGSMSSIGSHTKRWSASKEEDDELDLK................................................................................................................... 986
29 -11.200[K] COG5624 Transcription initiation factor TFIID, subunit TAF12 (also component of histone acetyltransferase SAGA)  ali follow..  8  4............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QHSSPGTPVQRPSAGPVNQAQFSQQRTNQLTSLLHTMTMYQQLAQNVGLNTPQGQVYLLQAQTIRRQLQGHAQSGQLPNQQLLQQLQSNGALQQGTPEPSNTRPRPQLNAQEQTMLLVRHRQLQTAQNYLTEMKEALGRIKNELSTNERLDTSAREALVKQESELTVKIAQFTAAISNGIRSIQQLQNRQASSANGNNTGTSTPVNASTDTRKSTASTPQLQQTQAQANAPQQRINPETSSVPETPVGVSAANVSNESTELATSATQQSGLANNVEKSQTPSYMSANHLPKVDSKSPIPFSVPPSRATLTGGYASGSIGLSTPGLSRAPHYELDNGNRLLSKRKLHDLLQQ-EEKIEPEVEELLLEIAD----VESVTNFACRLAKHRSDTLDVR---QLHLERN--NIRDDIV---SARKTGPTPSYQQKQ-----NAIGTAKSLNKD......... 450
30 -11.200[K] KOG1142 Transcription initiation factor TFIID, subunit TAF12 (also component of histone acetyltransferase SAGA)  ali follow..  8  4............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QHSSPGTPVQRPSAGPVNQAQFSQQRTNQLTSLLHTMTMYQQLAQNVGLNTPQGQVYLLQAQTIRRQLQGHAQSGQLPNQQLLQQLQSNGALQQGTPEPSNTRPRPQLNAQEQTMLLVRHRQLQTAQNYLTEMKEALGRIKNELSTNERLDTSAREALVKQESELTVKIAQFTAAISNGIRSIQQLQNRQASSANGNNTGTSTPVNASTDTRKSTASTPQLQQTQAQANAPQQRINPETSSVPETPVGVSAANVSNESTELATSATQQSGLANNVEKSQTPSYMSANHLPKVDSKSPIPFSVPPSRATLTGGYASGSIGLSTPGLSRAPHYELDNGNRLLSKRKLHDLLQQ-EEKIEPEVEELLLEIAD----VESVTNFACRLAKHRSDTLDVR---QLHLERN--NIRDDIV---SARKTGPTPSYQQKQ-----NAIGTAKSLNKD......... 450
31 -11.200[TZ] KOG1044 Actin-binding LIM Zn-finger protein Limatin involved in axon guidance  ali follow..  12  270.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SLGESPRTLSPTPSAEGYQDVRDRMIHRSTSQGSINSPVYSRHSYTPTTSRSPQHFHRPGNEPSSGRNSPLPYRPDSLPLTPTYAQAPKHFHVPDQGINIYRKPPIYKQHRALAAQSKSSEDIIKFSKFPAAQAPDPSETPKIETDHWPGPPSFAVVGPDMKRRSSGREEDDEELLRRRQLQEEQLMKLNSGLGQLILKEEMEKESRERSSLLASRYDSPIN--SASHIPSSKTASLPGYGRNGLHRPVSTDFAQYNSYGDVSGGVRDYQTLPDGHMPAMRMDRGVSMPNMLEPKIYEMLMVTN-RGRNKIREVD------RTRLER--HLAPEVFRE----MSIQEFDRLPLWRR-----NDMKKKAKL....................................... 625
32 -11.200[O] KOG2231 Predicted E3 ubiquitin ligase  ali follow..  10  346.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QRHVSIDAGNEEQFPTLRGASTAPSVSLVRPPPPSMRNLSGTSGLARTKENFPALGGGNGGGVTGPTSSSIAARAAQSQHPVAAVFKKPTSAAGSGSRSGPPGNGMLLHVSNRSAAVPKKAATPQVDFPALPGKGNKKNLRNLEEDMLPSGSPVPMANISAKHRSLADDYVSVASPSTFQKLQMVQKEEDEAKARQEALKKSAPKLTAAEFPSLGPSASASSSRTTAPKPSSGSPSLNWSKPANEKKQRELENRKAKVAPAPVLPSPTSKPAPKASNNNVQEQQANKKDKKQKDKKSNQENQPKTAKPKERNNNNEQKTNGAPSTPIRAPPGLKPGGPLKPPPGFVSNVTVNSVAKLPNNLTFTNSLGESYDIVPSPYTYTDPPDTEVRNQKLVDEVMS----LLKTPEALNEFRLLSSK----RDGSCSGQAY-QCAMLSSFYNLFPELAMLPDIKQQELYLVHKQHLNSLPPAERKSVPALEVCKVCKQTADL 841
33 -11.100[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  10  619..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTLQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSL------NKLKDLGHPVEEEDELESGDQEDEDDESE-KDLDHI 962
34 -10.600[U] KOG1955 Ral-GTPase effector RALBP1  ali follow..  12  336.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEQWETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGP-HRPVDADGLITHTSTSPQQIPEQPNFVDFSQFEVFAASNVNDEQDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTT---PKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIIRRNKETNTVLARLNSELQQQLKDV---EERISLEVQLEQL--------RPFSHL............ 744
35 -10.000[S] KOG4502 Predicted membrane protein  ali follow..  7  19............................................................................................................................................................................................................................................................................................................................................................................................................................................................LPLAPASPDFKADFSKLLKEAHQTDLMPVVEEDELQSLRHNGFQVFYTFHEQLHHLRQKTVGRNSATITEEMARIRNSIEDISEFSLDSNEVDEAINDITVPYGTKMKKSSKFAELSEIHNTDSSNKALPPFAFSEDQQESVDVVEKVEAVPPTTTTTKLTTLPSTTQSTTTRTTTQPSTIVSTRQKYVNVDGDIYVPGKTVISVSSTPIVDRTGTTTPVSIEISTTTLPPMTEIFTTKYSTLSTSYTHTPSPHIFSSSTVRLPIAIPIPTKLPEIMFTTPRPYRGPFITEFTIEPKRSEGRTSLRDRIRSTSQLLNLLGDKIGGIDQKAAGNRAEPKTGVLTNIYDQGVIKKRNLKTKQWGIAGEDPQGVQTYDGQFSGMAYGATKQRGGGYSMRKRMGKRPQKRGYKSRRLGDKRPEYMRPSTFVEKRTTDVSVPFGSHWREEWVRGVKLSER-RNAVRNVSENQKNVAQALLESEEASMR-KTLRKIREVVKIKTSSTTADVTTTNKPKTVKRSSLVY----QILLSLQKFLVIFILYFYKGAILP..... 571
36 -10.000[R] KOG2507 Ubiquitin regulatory protein UBXD2, contains UAS and UBX domains  ali follow..  13  116.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GKRTEPVAASSSSCAKTLDPNEVRSFAGADGSSSTGESQVVQTASENFRDPETTSVSNSPTGGVEEAKTNPPNSPVAASLASIPAAVSTSSLEGKSGSEAEAASPTALAAEKRAAASKVEGSATTSGAAARNFATNNLIPAVPLMTPAVPVPTQRPLEAQDNTESEERLAEVRNILEQKRKERVEEEKRMEKENELRRRRDGREAQSQQARAKEQEL--------KNMQEQIKRERQEELAARERIRAQIAADRAEQAQRFNTPDISSTTNSVAATAASNVITTDASVSSVDETRLQIRL--GGIQRTKSFPAGE--------VLATVRVYVRNEMLAASDVRDFT----TSYPRREFQTEDEVKTLNELNLVP------------NAVV--LVLTKEQVNRVVQS... 488
37 -10.000[S] KOG4670 Uncharacterized conserved membrane protein  ali follow..  9  113.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QTTPPHDLAATQIPPAPPSPSIQGQSVLSYSPSRSPSTSPKFTTSCMTGYSPQLQGLSSGGSGSYSPGVTYSPVSGYNKLASFSPSPPSPYPTTVGPVESSGLRSRYRSSPTVYNSPTDKEDYMTDLRTLDTFLRSEEEKQHRVKLGSPDSTSPSSSPTFWNYSRSMGDYAQTLKKFQYQLACRSQAPCANKDEADLSSKQAAEEVWARVAMNRQLLDHMDSWTAKFRN-VPLVQEIESVSTQMRRSITSLKQAALVKAPLIPTLDTILDLTPNQEYLFER--------IKELSQGGCMSSFRKWDTDLPTDSAIIMHVFSRLPPHPKYPDGKTF 474
38 -9.970[U] KOG1091 Ypt/Rab-specific GTPase-activating protein GYP6  ali follow..  10  457...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TKSCSTSPRSPLIIAPESYWEKKWRVLHKAEEEENKICLEKQTPPTQKKKRWLNVTKLFRAVIDLSHHKLGIGERKANSSPVTQSLLEDSSEQLNVDCHVTVNKENIHPQETEENIMEFHSADEESIVSGSSPSEESSFVSLDPTSPVRCSTKIENDSVSSAGSNLLPDEDDKSIVSISEENSSVSSDPISPAIDSNYSGKYLDCCTGSENDKDQQTSVNSPLSVSPHRRNEYPVTQSDEDVSTDKSVGITKEYKLLHGIV--------------QWFRKLKRTLSSEETSHRKASDATKTNDVKIKKNQIGCYSESHPQALSSGDSSQNLRKTLKNLGQSMLKHIEAIELVFQQEPCLVAGLIGNLAKTNLIEKGQVTATTALKEL---------RKLSNLLSEM............................................. 840
39 -9.950[S] KOG4511 Uncharacterized conserved protein  ali follow..  8  181..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SVLRHSKDEYDSMQKGSEELEMMAQNSRIQREALEQEIRKEEILLQQALDEGARAQNQNQNQGTSSTQTDGVNAPLRSVAAMMAATFAIDTATSTDDVTYKFLDQSTGTMTSSTGVSVGTLTNTGVSSGTMTSGVDTGTDADGTVGRPKSAKRVGSAVGKRSVSKGTPSEDAKKSSGSSSPDEAEKSKRERPGTSVKKAIGIVAANSEMSSNGTQMDVPVDEEGTKKRPGTTSKKSIATVTASPEMSSKTTQMEPEQDGEGKKRPETSKGANERKYSNAGLEDIVGPKSSPHEEKKSSHPSSRKGSKATDENAPATRPPSRKAAGGSHEPRAKTPNQKNKDERPTTRRSSVDKNAPKRNDSVPRERKSSVSHDESKPPKPIGPLRGNKYDGDVVLGRAESPGIDHGPRRKNLNDVNSHLVDTNRLNSSDVRVRLREQRDKLLQMK------NAERIKQMTDIQQNASLERPKTAARAREILDKDKK-------EAVAIRKEISDKLKTQ------ILTL............. 683
40 -9.820[K] KOG4196 bZIP transcription factor MafK  ali follow..  15  162..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HHHHHHQASPPPSSAASPAQQLPTSHPGPGPHATASATAAGGNGSVEDRFSDDQLVSMSVRENRHLRGFTKDEVIRLKQKRRTLKRGYAQSRYKRVQQKHHLE----EKTQLIQQVEQLKQEVSRL--ARERDAYKVKCEKLANS------GFREAGSTSDSPSSPE. 320
41 -9.720[D] KOG0267 Microtubule severing protein katanin p80 subunit B (contains WD40 repeats)  ali follow..  8  2.................................................................SLCGHTSPVDSV-SEEVLVLAGASSGVIKL-VRAFTGHRSNCSAV-PFGEFLASGSSDTNLRV-IQTYKGHTRGISTI-PDGRWVVSGGLDNVVKV-LHEFKCHEGPIRSLDFHPL-------------------FLLATGSADRTVKFWDLETFELIGTTRPEATGVRAI-PDGQTLFCGLDDGLK-CRDGVDMGWSTLGDFCINEGKFIGCSYYRNSVGIWVSDISELE-------------------------PYGAVSEDKNECMVKRFSVLNDQSERMGSGPRG-------SVSPDYETREIKNIYVDSTGGNLNVAQNPGSLKATLPLESGKVATMVSEKQNAAYFGPAGDKYSSTSRDSDSGEESSYSERESIPFSRTKSGMLLRPAHVRKTLAKFEESKQSAVVQSATRKKSGLAVEEEPQTQNAFLSEQNASKPFDAEDSIIKGITNKFEKALSSEPPTDEANRMFLKPPRIHRSSNSKYNDTRRAMSADPATFGKGGMENSGDVEDIPSKTERVLSREKPGDEQKNTEYPSGSRELNPVKIVEGVNVVSGRTRSLVEKFERGEKTTHTEGASTTIEQNNNAVQEDPRKTSRQTGETPVISTRRARSTPARVMPIVLNRDSNVTSDEPPLTQPARTSSFPVMPVILNQASNVTYDEPSVALTQESRTSHARILPVTFNQATNITSEEASVTLRRQRRNSAARVRPVLLSQATSHECPVTSVRPLRTSPARVMPTKLNQSVNMTSDTSHIASMHRVSPTQMLATPTVIDQVADMT-LDETHATQIQPACDNMPQKEEPNISDREDDSD---ITENLMLTHNEFLSTLQSRLTKLQDVKGAIGALRKL-TDQSVDVISIL-TEKIEILTL-----DMFSQL--VPVLTSL--LGSRTERPVNVSLDMLLKLVAIRSTVSAPRIVDL 921
42 -9.710[OJ] COG5193 La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation  ali follow..  10  2...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SHKEPSAAETSTVVHSEEDKAFCIGTGAVISEEREKEVLKNLQNSLTGKTAEENLNDEANHTSSDKSKSEDYQPSNVNVWALRKEKMIPKKHSHVKQEKRFSKSLQLQDPNVWPSPEIAEKQVEDRKLSDDSQKPLAPKANGKEKWVTITPNFTHTPISNRKSSRSRNDGSRRNGNGRRRGNYSSHGSNKRQTNYSREKDASRSIDSSNPSAEYRDDINNTFGSQTVSSANGKEVPQTSEDSSSQAPHHSSSSGHAPSQQ--------GVNPYLCDVQAFLTS----------QLEYYFSIEN---------LCKDMF----LRKH---MDDELAFLASFNRIKSF--------STDLNLLHAACKASDIIDVAIDLQ. 396
43 -9.700[S] KOG3819 Uncharacterized conserved proteins (Hepatitis delta antigen-interacting protein A)  ali follow..  18  5......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AGGAAAAAAAAESCSPAPAGSSAAPPAPVEDLSKVSDEESKEELIRSLRRAEAEKVSANRRLQLHLGEIRGLKDINQKLQEDNQE-LRDLCCFLDDDRQKGKRVSREAGVMHKEVALY--LQKLKDLEVKQEEVVKENMELKELCVLLDEEKG....... 177
44 -9.650[T] KOG3759 Uncharacterized RUN domain protein  ali follow..  16  2...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EMKMAEAQETKDSCSTIEGQLPAGPVRAED------EEEEVEVEQEQQELLSERWSPLGANYDDANSASSGVDCELEPGLEKSEARRGSTGSELAR------LRSIEE----EQELLTSSLLALTSHFAHVQLRVRQIVEAPAE---ERDQLLDLEDFAFQGIHGPDSQLIQQLKSLTELEQLDELRAK-PALSTEDNAIGEFVGPLKMKEQLTQITDL 267
45 -9.620[S] KOG4791 Uncharacterized conserved protein  ali follow..  8  344...................................................................................................................................................................................................................................................................................................................................................................................................................................................................EDATDKVNKVGEIHVKTLEEMLLERASQKHGESQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEEEHRQQEAERQKSKKDTTCIKLKTDSEIKKTVVLPPIVASKGQSEEPAGKTKSMQEVHMKTVEEIKLEKALRVQQSSESSTSSPSQHEATPGARLLLRITKRTWRKEEKKLQEGNEVDFLSRVRMEATEASVETTGVDITKIQVKRCEIMRETRMQKQQEREKSVLTPLQGDVASCNTQVAEKPVLTAVPGITWHLTKQLPTKSSQKVEVETSGIADSLLNVKWSAQTLEKRGEAKPTVNVKQSVVKVVSSPKLAPKRKAVEMHPAVTAAVKPLSSSSVLQEPPAKKAAVDAVVLLDSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGPSSSQMSMKTRRLSSASTGKPPLSVEDDFEKL----------------------------TWEISGGK----------LEAE-----------IDLEDDL--PLEL....................................... 805
46 -9.600[U] KOG1162 Predicted small molecule transporter  ali follow..  10  27..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KKQIKKIKTSRKPKPASHYPIGHHSDFGRSLFDPVRKLARTFSDKLFSNSEKPEILQVRRRRGSSETGDDVDEIYQTELVQLFSEEDEVKVFFARLDEELNKVNQFHKPKETEFLERGEILKKQLETLAELKQILSDRKKRNLSGSNSHRSFSSSVRNSDFSAGSPGELSEIQSETSRTDEIIEALERNGVSFINSATRSKTKGGKPKMSLRVDIPDAVAGAEGGIARSIATAMSVLWEELVNNPRSDFTNWKNIQSAEKKIRSAFVELYRGLGLLKTYSSLNMIAFTK------MKKFDKVAVKRSQFISSDKVVRL--MDEVESIFTKHFANNDRKKAMKFLKPHQTKDSH....... 383
47 -9.580[A] KOG2953 mRNA-binding protein Encore  ali follow..  11  3..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MSDTVTVKDETATMKDLEAEVKDTTRVENLIKSENYGK-------VEKNEHCIENNIDLQEKIQIQLTQSFEKEEKPSKDEAEKEKASDKLPRKMLSRDSSQEYTDSTGIDLHEFLVNTLKNN---RDRM------LLKLEQEILDFIGNNESPRKKFP---PMTSYHRMLLHRVAFGLDHNVKTIPDQKKRYILKRDNEREEEYQRARDRIFSQDSLCSQENYIID. 268
48 -9.510[K] KOG3863 bZIP transcription factor NRF1  ali follow..  15  421........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QLNGTANDTAGPELPDPLGGLLDEAMLDEISLMDLAIEEGFNPVQASQLEEEFDSDSGLSLDSSHSPSSLSSSEGSSSSSSSSSSSSSSASSSASSSFSEEGAVGYSSDSETLDLEEAEGAVGYQPEYSKFCRMSYQDPAQLSCLPYLEHVGHNHTYNMAPSALDSADLPPPSALKKGSKEKQADFLDKQMSRDEHRARAMKIPFTNDKIINLPVEEFNELLS---------KYQLSEAQLSLIR-RRGKNKMAAQNRKRKLD--TILNLER-DVEDLQRDKARLLRELRSLRQMKQVQSLQEVFGRLRDENGALVLLIPRTMADQQARRQER. 765
49 -9.440[R] KOG0431 Auxilin-like protein and related proteins containing DnaJ domain  ali follow..  8  541..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ERERERLVARQAVERATREARERAATEAHAKVQRAAVGKATDARERAERAAVQRAHAEARERAAAGARDKAAKAAAEAREKAEKAAAEAKERANAEAREKETRVRAERAAVERAAAEARGRAAAQAKAKQQQENTNDLDSFFSSISRPNSAPRQRTNPLDPFQDSWNKGGSFESSRESLRVPPGQPENLRKTSSVTNIVDDLSSIFGGSAISELPNLVGFKMLMEKLKRDDVPDWNATRGHRSGLQKHLLRKMNVIFKYKENKLRKIGSVIFLFNHHAYPGFQRIGVTDVEIKRWGAGKEGNL----ALLS-------TLQ-QPVSLTD-LITAASVKK--VYRK--DKVQQKGANL-KVFDMLKEAWNKFNSEEL 923
50 -9.400[U] KOG0999 Microtubule-associated protein Bicaudal-D  ali follow..  20  670......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EALMEEILKLKSLLSTKREQITTLRTVL------KANKQTAEVALANLKSKEKAMVTETMMKLRNELKALKELRAMFATREMQRQLEDEKKSLLRIQQKLALTQRL---ELL 799
51 -9.400[K] KOG4571 Activating transcription factor 4  ali follow..  15  215................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SDNDSGICMSPESYLGSPQHSPSTRGSPNRSLPSPGVLCGSAHPKPYDPPGEKMVAAKVKGEKLDKK---LKKMEQNKTAATRYRQKK------RAEQEALTGECKE--------LEKKNEA---LKERADSLAKEIQ----------LKD-----------LIEEVRKARGKKRVP..... 351
52 -9.360[R] KOG4678 FOG: Calponin homology domain  ali follow..  20  3.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NHSGRPEDPEPGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSP-----TSSNTPTPTKHLRTPSTKPKQENEGGE-KAALESQVRE---LLAEAKAKDSEINRLRSELKKYLEEKNKNFQKELSDLEEENREKLILTEKIQKMEEELQALSDQQQVQELTAENEKLVDEKTILETSFERAEQLSQ--ENEKL 362
53 -9.310[T] KOG4348 Adaptor protein CMS/SETA  ali follow..  11  327................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTE-----KLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVE-------------ELRTQVRE-------LRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQ---MEVN-DIK-----------KALQSK........................... 665
54 -9.280[S] KOG2465 Uncharacterized conserved protein  ali follow..  8  359...................................................................................................................................................................................................................................................................................................................................................................................................................................................................AKARSENEGLDSLASEVSEIEAGDLRDDQQRPAFSASAAKLHPNPNCETHKLATGDQEKLTQESPRESTSSAPAEVAVPAVTPPPLSAAVEVTVSGDVSVTGHSSTTGCNCFGGKKCKKRWASAKNTDTPEMSEVYCPSCEDPSNESPACLAKMPDKRPTRLKPKSSILSVESELLVGKRSSFRLPSEIKRKQQGGSITRSASLSAADRRTSLPVATKRIIPPRLRTAKAKDLEKDKEKEKDKNKENDKKSSNQKV-NGSATNFLAKMSPKRLKAGKEKDKDKDGNKEKEKDKFKAMDAAKKKAVNNNNPKPDISKSEEYEIADDATSLNGSESEPVGAAKMVILSESDSKLMISVRGREELPVVDSPKTPPKRFEKCVSLPVEPESHLLQPDENNENEQSDITNVISPTELTPMLDVANGNGEANSATLPRTAKQAHVSKMLHLVPKRRTPDGTNIYYWCDVP---------------------------KKAIKELDDGAYN----QSFHFWKE-NRRQQS-NAFLTSIAKDLLDHRETP..... 885
55 -9.250[K] KOG2483 Upstream transcription factor 2/L-myc-2 protein  ali follow..  12  2...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EQQLNLGHLLTAARLLDIGALDISSLDLGALTSTSSSPGSSSPAMFDLSNESELRSLFCGKLKVDKKQSSCASNASTSSQPYCSSPPARKSSKHSRTAHNEL--EKTR-RANLRGC---LETLKMLV--------------PCVSDATRNTTLALLTRARDHIIELQ-----DSNAAQMKKLNDLRDEQDELVAELAQLQADEE....... 180
56 -9.140[S] KOG4805 Uncharacterized conserved protein  ali follow..  8  83...................................................................................................................................................................................................................................................................................................................................................................................................................................................................SESCHDGYQHQEKMRQKIKEVEEKQPEVKTGFIASFLDFLKSGPKQQFSTLAVRMPNRTRRPGTQMVRTFCPPPLPKPSSTTPTPLVSETGGNSPSDKVDNELKNLEHLSSFSSDEDDPGYSQDAYKSVSTPLTTLDATSDKKKKTEALQVATTSPTANTTGTATTSSTTVGAVKQEPLHSTSYAVNILENISSSESSKPIELDGLPSDQFAKGQDTVAIEGFTDEEDTESGGEGQYRERDEFVVKIEDIETFKEALKTGKEPPAIWKVQKALLQKFVPEIRDGQREFAATNSYLGYFGDAKSKYKRIYVKFIENANKKEYVRVCSKKPRNKPSQTIRTVQAKPSSSSKTSDPLASKTTTTKAPSVKPKVKQPKVKAEPPPKKREKWKEEFSSSQSDSSPEIHTSSSDDEEFEPPAPFVTRFLNTRAMKEFKSYMELLALDPDTMQALEKSNDELLLPHMKKIDGMLNDNRKRLLLNLH-LESKAYNKKTLRQLYSVLKRVVKYM--CVCILSMYSVNNDLIYCSESLCYVLC-----SDLPEPHHL 723
57 -9.090[K] KOG3915 Transcription regulator dachshund, contains SKI/SNO domain  ali follow..  13  411....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IANMAAAAQVQSPPSRVETSVIKERVPDSPSPAPSLEEGRRPGSHPSSHRSSSVSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHESKRMHIEKDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLFPDGLSSIEIQGL--KVAIDNARAQEKLEKTELKM-ELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQE---ALEFETKTLKQAASTDSLRVLNDSLTPEIEA-----DRSGGRTDAERTIQ. 694
58 -9.090[S] KOG4615 Uncharacterized conserved protein  ali follow..  10  227...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EFEETVNLTRSISSPVNFLPEISSTPCTEKQKEEVAKNTTRVETDKPAEKPMELSQEPEPENPLQTKVTSPARNPILAAEIEQICKERQSSFHKNVLQLDYSGRAPYSRPPTPSSPSVAGLRRTYTMEKGPAPGQLLLSPSHRYDTPSKMPVVKAKRFNQELMVPDTPERQSHDPAWQSEPQPEFVVPETQPQDLGELVQTLSRSAISPIVVINTSNSNRSVRRDAVAMKSVPTSPVTALSSPPIAPSPRRSA------AASPQKSIAQLPRVEENMDAIMTDDESDEHPSTVPLNLAPSGGNTTRQRRLRSSNRARATIESQESSMRLL---------NLHKSVNAKKSKPRKTAIPLNKAPSANGEQFAR--ELTRMSNYEILDLRKR--------NSLNEIYPLNGHRNHREKLILEEEIQRELLRRLMDEAEMIDRRDE 649
59 -9.080[T] KOG2290 Rhomboid family proteins  ali follow..  9  2................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SEARRDSTSSLQRKKPPWLKLDIPSAVPLTAEEPSFLQPLRRQAFLRSVSMPAETAHISSPHHELRRPVLQRQTSITQT-SKDSDSTQKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRVADDTAEGLSAPHTPVTPGAASLCSFSSSRSGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRARRRSFTPASFLEEDTTDFPDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKAPEQADLTGGALDRSELERSHLMLPLERGWRKQKEGAAAPQPKVRLRQEVVSTAGPRRGQRIAVPVRKLFAREKRPY---RTYRKRIDSFVKRQIEDMDDRPTFVHS--IAPVGFSQHE-TVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKVHSFIRSARERE. 496
60 -9.000[B] KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats)  ali follow..  17  4...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QSRHPTPHQAAGQPFK-----TIPESDRIKEEFQFLQAQYHSLKLECEKLASEKTE--MQRHYVMYYEMSYGLNIEHKQTEIAKRLNTI--CAQVIPFLS-----QEHQQQVAQAVER-AKQVTMAELNAI 122
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;