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Query: [L] KOG0542 Predicted exonuclease, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSINFTRTPRLLLDTVAHYSSFLESTKLVKTREVKKPPRYPNFSLKKDTKNQKMSQHFDYLLVLDFEATCQDNWKGPMHPVQEIIEFPVVQLSTADWSEIRRFHQYVKPTECPRLTSFCTSLTGIIQEMVDEKPTLPQVLSEFDSWLKEDSRLEKGKFAFVTCGDWDLKVALPNEAKFKNIGIPEYFNQWINVKKASAEHTNHFAKGIAQLLAIYKLQHQGRHHSGIDDVANICEIVRCLGMNGHNYQITGSKDTMTRRVFRDARKLast
1 -110.000[L] KOG0542 Predicted exonuclease  ali  100  1MSINFTRTPRLLLDTVAHYSSFLESTKLVKTREVKKPPRYPNFSLKKDTKNQKMSQHFDYLLVLDFEATCQDNWKGPMHPVQEIIEFPVVQLSTADWSEIRRFHQYVKPTECPRLTSFCTSLTGIIQEMVDEKPTLPQVLSEFDSWLKEDSRLEKGKFAFVTCGDWDLKVALPNEAKFKNIGIPEYFNQWINVKKASAEHTNHFAKGIAQLLAIYKLQHQGRHHSGIDDVANICEIVRCLGMNGHNYQITGSKDTMTRRVFRDARK 266
2 -90.000[R] COG5018 Inhibitor of the KinA pathway to sporulation, predicted exonuclease  ali follow..  24  1...............MESPVQILVWPFPCDEMNQKTPSTVEEIRIALQELGLSTNGNKRYLLIVDVEATCEEGCG--FSFENEIIELPCLLFDLIEKSIIDEFHSYVRPSMNPTLSDYCKSLTGIQQCTVDKAPIFSDVLEELFIFLRKHSNILVPNWAWACDGPWDMASFLAKQFKYDKMPIPDWIKPFVDIRSFYKDVYRVPRTNINGMLEHWGLQFEGSEHRGIDDARNLSRIVKKMCSENVEFECNRWWMEYEKNGWIPNRS 270
3 -43.500[R] KOG4198 RNA-binding Ran Zn-finger protein and related proteins  ali follow..  15  1...........................................MSKLPSPTMPLPESVGDLVVLHFETNLDDHGISIGRAPCEIHEICWVILDGKTLEKQHCESCSIRE--DSSRHGICGSASSLTE-----------AIFTLDNSIQERLNFQGKPFTFVVMNGRELRVLLPKEARDQGITLPSYMRHPFDLSSEYAKWQIRMGAVPPYTITLSHIFGKLDVDSLPPITESKAIELSPSDAPYITKGLTQCWRLAN......... 203
4 -40.800[L] COG0847 DNA polymerase III, epsilon subunit and related 3`-5` exonucleases  ali follow..  18  12............................................................IVVLDTETTGMNREGGPHYEGHRIIEIGAVEI--INRKLTGRFHVYLKPDR--DIQLEAIEVHGITDEFLKDKPEYKDVHEEFVDFIKGA--------ELVAHNAPFDVGFMDYEFAKLGGAIGSDFCKVTDTLAMAKRIFPGKRNNLDILCERYGIDNSHRLHGALLDAEILADVYLLMTGGQTSLQFSSVTQNSGELSAESLKR 209
5 -33.200[L] KOG4793 Three prime repair exonuclease  ali follow..  12  2................................................GSQALPPGPMQTLIFFDMEAT------GLPFSQPKVTELCLLAVHRCAPRVVDKLSLCVAPGK--ACSPAASEITGLSTAVLAAHGNLANLLLAFLRRQPQ-------PWCLVAHNRYDFP-LLQAELAMLGLTSALDGAFCVDSITALKALEPRKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQA....................... 214
6 -31.300[A] COG1949 Oligoribonuclease (3`  ali follow..  11  3................................KTSMIHAIVDQYSHCEWVENSMSANENNLIWIDLEMTGLDPER------DRIIEIATLVTD-ANLNILAEGPTIAVHQSDEQLAL-THTASGLVERVKASTMGDREAELATLEFLKQWV--PAGKSPICGNSIGQDRRFLFKYMPELEAYFHYRYLDVSTLKELARRWKPEILDGFTKQ----------GTHQAMDDIRESVAELAYYREHFIKL................... 204
7 -31.200[A] KOG3242 Oligoribonuclease (3`  ali follow..  13  1.....................................................MSNLKQPLVWIDCEMTGLEVGK------HVLMEVAAIITDGNLRPVEEKFDAVIKLDEKSEMNDWCIEQSGLTERCRQSNLTVKDVENQLLAYIKKY-IPKKREALIAGNSVHADVRFLSVEMPKIIEHLHYRIIDVSTIKELA----------KRWCPDIPAYDKKGD-HRALSDILESIGELQHYRSY....................... 177
8 -23.400[L] COG2925 Exonuclease I  ali follow..  10  9..........................................................STFLFHDYETF------GTHPALDRPAQFAAIRTD-SEFNVIGEPEVFCKPADDYLPQPGAVLITGITPQEARAKGAFAARIHSLFTVPKTCILGYNN----VRFDDEVTRNIFYRNFYDPYAWSWQHDNSRWDLLDVMRACYGLPSFRLEHLTKANGIE-HSNAHDAMADVYATIAMAKLVKTR....................... 200
9 -18.500[L] KOG2249 3`-5` exonuclease  ali follow..  15  110............................................................CVAIDCEMV----GTGPRGRVSELARCSIVSYHGD-------YDKYIRPE--MPIADYRTRWSGITRQHMRKAVPFQVAQKEILKLLKGKVVVGHA---------------LHNDFQALKYVHPRSQTRDTTYVPNFLSEPGLARVSLKDLALQLKIQVGQHGHSSVEDATTAMELYRLVEVQ....................... 272
10 -14.100[L] KOG2248 3`-5` exonuclease  ali follow..  18  268............................................................ILAIDCEMVRTENG----------LEIARVTIVDMKSEVI--YDEFVKPE--SPVTDYVTQYSGITEEKLRNVTVLSDVQSYLKKTVDNNTVLLGHS--------------LNSDLNCLKFTHPHI----IDTANIYNHTRGPPKPSLKWLATKWEIQKAGALHDSAEDALACVDLLKLKVKNGPAF................... 428
11 -12.500[A] COG5228 mRNA deadenylase subunit  ali follow..  10  46............................................................VVSMDTEFPGVVARPLGVFKSSKIIQIGLALSDEEGNAACTWQFNFTFNLQDDMYAP--ESIELLTKSGIDFKKHQEVGIEDFAELLIGSGLVLQEEVTWITFHSGYDFAYLLKAMTQIPLPLCIYFPKNYDIKYIMKSVLNNSK-GLQDIADDLQIHRIGPQHQAGSDALLTARIFFEIRS........................ 253
12 -11.900[L] COG3298 Predicted 3`-5` exonuclease related to the exonuclease domain of PolB  ali follow..  8............................................................LCVFDIE-TIPNISLCKEHFQLKEDDALKICEWSFEKQKEKSGSEFLPLYLHEIIS-IKVGNFGQKHENKEDFASEKELLEDFFKYFNEK------QPRLISFNGFDI-PLLTLKALKYNLTLDAFYSQHLDLMDSLSHYGSVRGLNLNGVCSMTNIP-NPHLSQKQSDVLNTYWLFLKYEVLKGALNKEQYLGLLNDFLAKFPKE 257
13 -11.800[A] KOG0304 mRNA deadenylase subunit  ali follow..  36............................................................YIAMDTEFP---QLLRCNVDLLKIIQLGLTFTNEKGEYPSGINTWQFNFKFNLTEDMYSQDIDLLANSGLQFQKHEEEGIDHFAELLMTSGVVLCDNVKWLSFHSGYDFGYMVKLLTDSRLPLNLFFPSIYDVKYLMKSCKNLKG-GLQEVADQLDLQRIGRQHQAGSDSLLTGMAFFRMKEL....................... 244

FFAS is supported by the NIH grant R01-GM087218-01
1 4 5 9 0 4   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Functional differentiation of proteins: implications for structural genomics. Structure. 2007 Apr;15(4):405-15.