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Query: [T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac GTPases, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKGGDRAYTRGPSLGWLFAKCCCCFPCRDAYSHSSSENGGKSESVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSSLLAARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPARLPQASPRPYSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMGILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAADGATISWKENFDSLast
1 -154.000[T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac GTPases  ali  100  1MKGGDRAYTRGPSLGWLFAKCCCCFPCRDAYSHSSSENGGKSESVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSSLLAARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPARLPQASPRPYSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMGILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAADGATISWKENFDS 985
2 -75.900[R] KOG3518 Putative guanine nucleotide exchange factor  ali follow..  18  343...............................SATKAKEFVCSEPLSPVDIVDTINFDLVAQHMERLTLADPGDLDPRAELIEAVNKTLVNKPLVRSSSAACASTICSSPLLTYARTKS-AKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWERACLRV---DELQILFANIEEIYEFNSM-LLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHC-----DVKEVVEAHVIMRQVAHNIDQVKRKQEQQSLGPELTVLGELRQEGLLME--------QHNKQRLVLLFATMLIITKQKED----GRLQFKTYISQNNLMLSEHLPGEPTSFYVIPDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIMRAKELVYQLGNEEGECFPLG.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 867
3 -60.500[F] KOG2070 Guanine nucleotide exchange factor  ali follow..  14  218.......................................................................................................................................................................................................REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSS--ANISYLMGNLEEICSFQQM-LVQSLEECTKLPQRVGGCFLNLMPQMKLYLTYCANHPSAVNVLTEHSEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKTEAIRNWEGDIKTLGNVTYMSQVLIQCAGSE---EKNERYLLLFPNVLLMLSASP---RMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSIERILVSCNNQQDLQEWVEHLQKQTKVTS------VGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAP................................................................................................................................................................................................................................................................................................................................................................................. 638
4 -44.400[T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange factor/faciogenital dysplasia protein 3  ali follow..  16  1.............MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLT--TPQQKLLSQHLPQRQGNDADKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQERE------------NGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMNKIFSNISSINAFHSKFLLPELEKRMQE-PRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNFKSVVEEIQKQ--GSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAINLKKLLEIYEMLGEEEDIVNPSNELIKEGQAARNTSAQERYLFLFNNMLLYCVP-KFSLVGSKFTVRTRVGIDGMKIVETQNEEPHTFQV--SGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSE.................................................................................................................................................................................................................................................................................................................................................................................................................................................. 543
5 -42.300[T] KOG2996 Rho guanine nucleotide exchange factor VAV3  ali follow..  18  107..................................................................................................................................................KVIETLSRLSRTPIALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEF----DSVFINIPELVKLHRN-LMQEIHDSIVNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYVKLKLEECSKRANGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDP-TEKANLKLALDAMKDLAQYVNEVKRQLSIENLNQPVLLFGRPQGDGEIRITTLDKH---TKQERHIFLFDLAVIVCKRKGDN-----YEMKEIIDLQQYKIANNPTTDSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSN....................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 503
6 -36.100[T] COG5422 RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases  ali follow..  17  395...................................................................................................................................................................................RRLEQQARLHLKVQPVLSGGSTSITDKQEEDHRLWSENVPKQVVDQIDVREWKRQEIIFEVIYTERDFVRDLEYIRDFWIKPLSTSNVENNRQQFIRCVFHNIMQIHAVNSR-LSNALNRTQTL-NTIGDLFLDYVPKFEPFIKYGANQAIAKFEFERFANYVHEVERL--RKLELNGYLTKPTTRLARYPLLLSGVLKYTDKDNPDTENIPRVIEMIREFLTKLNYETNRLSLLQLNEQLDPSRLLIFKGVVKLKASSYSNGDTENDIHMFLLDNFLLLCKIKIQMKRRVHKLHLRPLPLELLSISYIEDSPSRGLQL-IGARGFSISLYLNTLIARDQWKQHIEK........................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 800
7 -31.700[T] KOG3524 Predicted guanine nucleotide exchange factor (PEBBLE)  ali follow..  14  278..................................................................................................................................................VSLHRGCCAIEDNFALPTGKLHRKPLESSSVSSPIGKSLRSQNSRSLSSMRDCSVEGPTSLNMTPDYIYSNDDVENSCKSPRQPSKRLRVCMEMVETEKNYLSLLKLVVKFKEALECEISHNEFMSRSDAMMFGKLDPILELHER-IFARLTVMSNE-LDFAQVWIDAKEEMKAYPQYINSYDTIKRLFDKFHTFCKAKESN--HRLKLTDLMVKPVQRLPSVILLLKEMAKKSDSKLKN--NAEEAAKAIDEVLKTANKTREFTDIENVPPILVAANRFIRELVVSPIASTSPGLQQFAKMKLFLFHDVLIITKIRSEKNTRRPYRYIDQIQLNTMRSAFRIRAPDEILELQQQNGSTK-VFESNDDEEVRDFLDDIHVKILSDCGRFFYSSDPSDMNEINDAMVSDMTTRYFRNLCGAKPQYGHGSQMNITEWSHNESFMPPPQSQSRMRRAFSNAQLTLATTLGFGRNQSRNN........................................................................................................................................................................................................................................................................................................................................................................... 827
8 -23.600[T] KOG4269 Rac GTPase-activating protein BCR/ABR  ali follow..  16  1.............................................................................................................................................MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGRGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLL-PMKPLKATTTSQPVLTIQQIIFYKIQDIYEIHKE-FYDNLCPKVQQQVTMGHLFQKLASQLGVYKAFVDNYKVALETASQSNNQFQKISEELHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDID-PRRTAVTTPKGETRQLVKDGFLVEVSESSR-----KLRHVFLFTDVLLCAKLKKTSAGKHQYDCKWYIPLADLVFPSPEE---------SEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKK...................................................................................................................................................................................................................................................................................................................................................................................................................................................... 410
9 -15.900[R] KOG3515 Predicted transmembrane protein of the immunoglobulin family of cell adhesion molecules  ali follow..  13  1.....................................................................................................................................................................................................................................................................MEGQIIPA---GSVQKL-GNPLATLTWYKN---KRINSVIRAADKSVSAEITVSDNQAQYRCEASNSATEIPLFQS-----EPEELRPGMEATIICDS-NPPAKLS-----WKDGIPIEAIWQLEACPSQFAMDLPAPPVHFAGARRFHDNIRFACQSLKLRPFFLRTHSYLIPLPCP--------------IRILCPCPPTGTPDMPQPTGINNTVSTLEFRVNVTQEMN-----------GQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGI---------------------------------YSCSASNSQGGATLNITVVVEY-----------------------GTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTS---YLHIKDAKREDVGNFRCVADNRTNRDILLIVKFAPEIAKTLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPPLSLNILNVTHDTVTLAWTPG--FDGGLKASYRVRYRMADREQYKYIDGLPNSHKLTIGGLRMNTLYLFSVMSWNELGQSSYLPDLARAETKEAPPPSHPASSL....... 661
10 -13.400[T] KOG4194 Membrane glycoprotein LIG-1  ali follow..  10  55..............................................................................................................................................................................................................................................RILLLSDNEIESIDKSRLKGFYFLQTLDISNNIRHIDFEFFYNLPNLKILNRKNRLARIPRGSHELGHLEKLDLRSNLISTVTSEELSYLAAVRSVDLSRNLIIEKLDLASNSITDIGTDHFSSFNTLVTLKL-ITTLLESLDLTRNMIREVRNQLPSLQNVSLARNDVYRLD--DGMFYACEGLKHLNLSTNRVQAVTEGWMFGLTSLEVLDLSYNQI---------QSFHISSWSHTPKLKWLSLHSNRIQSLPSGSFRVLRQLEELILSANSIDLHKFALVGMSSLHKLDLSSNTLAVCVEDGAVLYNTSMPFLRSLRFTNNQLRVIPKRAFERFPALEELDLTDNPIATIHPEAFEPLELKRLVMNSSSILCDCQISWLASWIYRLKLDKSSIIAKCSYPPPLADLYVVAIDTANLTCHNDSPRAKIVRQPVEVSTLIGEKARFTCNVYGASPLSIEWRVMENGQPRVLVQDSATFLSINRTAVVNGTFDERELAAAELLLDNVAMTDNSEYQCVARNRFSTHVKLQVYQAPKFTYTPEDMPLLVGQTAKFLCAATGTPRPEIKWAFEQIPFPAAEARRLYVTPNDD-----HIYIMNVTKEDQGAYTCHATNVAGQTQASANLIVFENFFH---YPESPDLSPMLIKKRDALKIDCSCDLSRQRMVWKRQQQVILFLKKAKFNDQILTLTQTTFSDSGEYSCELWVDDTILMRKITMVKVVNEDEFVSSEATLTQ....... 816
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Dunbrack RL Jr, Dunker K, Godzik A. Protein structure prediction in biology and medicine. Pac Symp Biocomput. 2000;(12):93-4.